CN102406554B - 防晒剂组合物 - Google Patents
防晒剂组合物 Download PDFInfo
- Publication number
- CN102406554B CN102406554B CN201110270912.7A CN201110270912A CN102406554B CN 102406554 B CN102406554 B CN 102406554B CN 201110270912 A CN201110270912 A CN 201110270912A CN 102406554 B CN102406554 B CN 102406554B
- Authority
- CN
- China
- Prior art keywords
- compositions
- approximately
- mineral
- weight
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 96
- 230000000475 sunscreen effect Effects 0.000 title abstract description 11
- 239000000516 sunscreening agent Substances 0.000 title abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
- -1 fatty acid ester Chemical class 0.000 claims abstract description 39
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 38
- 239000011707 mineral Substances 0.000 claims abstract description 38
- 229920002472 Starch Polymers 0.000 claims abstract description 18
- 239000008107 starch Substances 0.000 claims abstract description 18
- 235000019698 starch Nutrition 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 239000000194 fatty acid Substances 0.000 claims abstract description 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 10
- 229930195729 fatty acid Natural products 0.000 claims abstract description 10
- 239000011248 coating agent Substances 0.000 claims abstract description 7
- 238000000576 coating method Methods 0.000 claims abstract description 7
- 239000003921 oil Substances 0.000 claims description 24
- 235000013339 cereals Nutrition 0.000 claims description 23
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 239000003349 gelling agent Substances 0.000 claims description 14
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 9
- 229910052710 silicon Inorganic materials 0.000 claims description 9
- 239000010703 silicon Substances 0.000 claims description 9
- 239000004575 stone Substances 0.000 claims description 8
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 6
- 239000002480 mineral oil Substances 0.000 claims description 6
- 235000010446 mineral oil Nutrition 0.000 claims description 6
- 229920000728 polyester Polymers 0.000 claims description 6
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 5
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 claims description 4
- JIHQDMXYYFUGFV-UHFFFAOYSA-N 1,3,5-triazine Chemical compound C1=NC=NC=N1 JIHQDMXYYFUGFV-UHFFFAOYSA-N 0.000 claims description 3
- XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 claims description 3
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 claims description 3
- 239000012964 benzotriazole Substances 0.000 claims description 3
- 229940114081 cinnamate Drugs 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 229960000601 octocrylene Drugs 0.000 claims description 3
- 229940100486 rice starch Drugs 0.000 claims description 3
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims description 3
- 229960001860 salicylate Drugs 0.000 claims description 3
- 238000001179 sorption measurement Methods 0.000 claims description 3
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 3
- MSRNSQQZMXWASL-UHFFFAOYSA-N C(CC(O)(C(=O)O)CC(=O)O)(=O)O.C(CCCCCCC)C(CCCCCCCCCCC)O Chemical compound C(CC(O)(C(=O)O)CC(=O)O)(=O)O.C(CCCCCCC)C(CCCCCCCCCCC)O MSRNSQQZMXWASL-UHFFFAOYSA-N 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 abstract description 3
- 239000004904 UV filter Substances 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 235000019198 oils Nutrition 0.000 description 22
- 150000001875 compounds Chemical class 0.000 description 21
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 15
- 239000001993 wax Substances 0.000 description 15
- 229920000642 polymer Polymers 0.000 description 13
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 12
- 239000002245 particle Substances 0.000 description 11
- 229920001577 copolymer Polymers 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 241000276489 Merlangius merlangus Species 0.000 description 9
- 239000010408 film Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 239000010409 thin film Substances 0.000 description 9
- 230000002209 hydrophobic effect Effects 0.000 description 8
- 229920001558 organosilicon polymer Polymers 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 description 6
- 238000007654 immersion Methods 0.000 description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 6
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 5
- 206010013786 Dry skin Diseases 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 230000037336 dry skin Effects 0.000 description 5
- 230000001804 emulsifying effect Effects 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 125000005456 glyceride group Chemical group 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000003981 vehicle Substances 0.000 description 4
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical class CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 239000007848 Bronsted acid Substances 0.000 description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
- 241001597008 Nomeidae Species 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 230000003796 beauty Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000019325 ethyl cellulose Nutrition 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- 150000002576 ketones Chemical class 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 229920001897 terpolymer Polymers 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- 229920000856 Amylose Polymers 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 239000001856 Ethyl cellulose Substances 0.000 description 2
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- 239000001828 Gelatine Substances 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 150000001721 carbon Chemical group 0.000 description 2
- 239000007765 cera alba Substances 0.000 description 2
- 150000005690 diesters Chemical class 0.000 description 2
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229920001249 ethyl cellulose Polymers 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 150000003921 pyrrolotriazines Chemical class 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 229910052723 transition metal Inorganic materials 0.000 description 2
- 150000003624 transition metals Chemical class 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 238000002211 ultraviolet spectrum Methods 0.000 description 2
- OIQXFRANQVWXJF-LIQNAMIISA-N (1s,2z,4r)-2-benzylidene-4,7,7-trimethylbicyclo[2.2.1]heptan-3-one Chemical compound O=C([C@]1(C)CC[C@H]2C1(C)C)\C2=C/C1=CC=CC=C1 OIQXFRANQVWXJF-LIQNAMIISA-N 0.000 description 1
- AFDXODALSZRGIH-QPJJXVBHSA-N (E)-3-(4-methoxyphenyl)prop-2-enoic acid Chemical compound COC1=CC=C(\C=C\C(O)=O)C=C1 AFDXODALSZRGIH-QPJJXVBHSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- DMBUODUULYCPAK-UHFFFAOYSA-N 1,3-bis(docosanoyloxy)propan-2-yl docosanoate Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCCCCCC DMBUODUULYCPAK-UHFFFAOYSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- MEZZCSHVIGVWFI-UHFFFAOYSA-N 2,2'-Dihydroxy-4-methoxybenzophenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1O MEZZCSHVIGVWFI-UHFFFAOYSA-N 0.000 description 1
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 description 1
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 description 1
- ZKYCLDTVJCJYIB-UHFFFAOYSA-N 2-methylidenedecanamide Chemical compound CCCCCCCCC(=C)C(N)=O ZKYCLDTVJCJYIB-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 241001044369 Amphion Species 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 206010003645 Atopy Diseases 0.000 description 1
- 235000021357 Behenic acid Nutrition 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- KLABQACQQIXBMU-UHFFFAOYSA-N C(C)N(C1=CC(=C(C(=O)C(CC2=C(C(=O)O)C=CC=C2)CCCC)C=C1)O)CC.C(C1=CC=CC=C1)(=O)O Chemical compound C(C)N(C1=CC(=C(C(=O)C(CC2=C(C(=O)O)C=CC=C2)CCCC)C=C1)O)CC.C(C1=CC=CC=C1)(=O)O KLABQACQQIXBMU-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- GWPZQWJNTQGLFJ-UHFFFAOYSA-N N(=O)OC(C)CCCCCC.CN(C1=CC=C(C(=O)O)C=C1)C Chemical compound N(=O)OC(C)CCCCCC.CN(C1=CC=C(C(=O)O)C=C1)C GWPZQWJNTQGLFJ-UHFFFAOYSA-N 0.000 description 1
- BFWXAYQEKYNZQU-UHFFFAOYSA-N N(=O)OC(C)CCCCCC.OC1=C(C(=O)O)C=CC=C1 Chemical compound N(=O)OC(C)CCCCCC.OC1=C(C(=O)O)C=CC=C1 BFWXAYQEKYNZQU-UHFFFAOYSA-N 0.000 description 1
- CQVBAECKHLTOTQ-UHFFFAOYSA-N N1N=NC2=C1C=CC=C2.C(C2=C(C(=CC(=C2)C(CC(C)(C)C)(C)C)N2N=C1C(=N2)C=CC=C1)O)C1=C(C(=CC(=C1)C(CC(C)(C)C)(C)C)N1N=C2C(=N1)C=CC=C2)O Chemical class N1N=NC2=C1C=CC=C2.C(C2=C(C(=CC(=C2)C(CC(C)(C)C)(C)C)N2N=C1C(=N2)C=CC=C1)O)C1=C(C(=CC(=C1)C(CC(C)(C)C)(C)C)N1N=C2C(=N1)C=CC=C2)O CQVBAECKHLTOTQ-UHFFFAOYSA-N 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920002396 Polyurea Polymers 0.000 description 1
- 229910002808 Si–O–Si Inorganic materials 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- HEAHZSUCFKFERC-IWGRKNQJSA-N [(2e)-2-[[4-[(e)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid Chemical compound CC1(C)C2CCC1(CS(O)(=O)=O)C(=O)\C2=C\C(C=C1)=CC=C1\C=C/1C(=O)C2(CS(O)(=O)=O)CCC\1C2(C)C HEAHZSUCFKFERC-IWGRKNQJSA-N 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 229920006322 acrylamide copolymer Polymers 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- UBNYRXMKIIGMKK-UHFFFAOYSA-N amiloxate Chemical compound COC1=CC=C(C=CC(=O)OCCC(C)C)C=C1 UBNYRXMKIIGMKK-UHFFFAOYSA-N 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WXBLLCUINBKULX-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1 WXBLLCUINBKULX-UHFFFAOYSA-N 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 150000001565 benzotriazoles Chemical class 0.000 description 1
- 229960004217 benzyl alcohol Drugs 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 229940025250 camphora Drugs 0.000 description 1
- 239000010238 camphora Substances 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- 229940073532 candelilla wax Drugs 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000007766 cera flava Substances 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- MXOAEAUPQDYUQM-UHFFFAOYSA-N chlorphenesin Chemical compound OCC(O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-UHFFFAOYSA-N 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- DIOQZVSQGTUSAI-NJFSPNSNSA-N decane Chemical class CCCCCCCCC[14CH3] DIOQZVSQGTUSAI-NJFSPNSNSA-N 0.000 description 1
- 125000005131 dialkylammonium group Chemical group 0.000 description 1
- VILAVOFMIJHSJA-UHFFFAOYSA-N dicarbon monoxide Chemical group [C]=C=O VILAVOFMIJHSJA-UHFFFAOYSA-N 0.000 description 1
- 125000005594 diketone group Chemical group 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000006471 dimerization reaction Methods 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- UHUSDOQQWJGJQS-UHFFFAOYSA-N glycerol 1,2-dioctadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCCCC UHUSDOQQWJGJQS-UHFFFAOYSA-N 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052809 inorganic oxide Inorganic materials 0.000 description 1
- 125000003010 ionic group Chemical group 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 239000004611 light stabiliser Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000012184 mineral wax Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- KPMKEVXVVHNIEY-RITPCOANSA-N norcamphor Chemical compound C1C[C@@H]2C(=O)C[C@H]1C2 KPMKEVXVVHNIEY-RITPCOANSA-N 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- AFDXODALSZRGIH-UHFFFAOYSA-N p-coumaric acid methyl ether Natural products COC1=CC=C(C=CC(O)=O)C=C1 AFDXODALSZRGIH-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- PXDJXZJSCPSGGI-UHFFFAOYSA-N palmityl palmitate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000003333 secondary alcohols Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- PIWNJAZCHHBADQ-MECALSEWSA-N tr-2 mycotoxin Chemical compound O=C1[C@@H]2CCCN2C(=O)[C@]2(O)[C@@H](O)C(C3=CC=C(C=C3N3)OC)=C3[C@H](CC(C)(C)O)N21 PIWNJAZCHHBADQ-MECALSEWSA-N 0.000 description 1
- 125000005208 trialkylammonium group Chemical group 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000004078 waterproofing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/895—Polysiloxanes containing silicon bound to unsaturated aliphatic groups, e.g. vinyl dimethicone
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
本发明公开了防晒剂组合物，所述防晒剂组合物包含分散于连续水相中的不连续油相、至少10重量％的有机紫外线滤光剂、水不溶性的C2-C8液态有机硅、多质子羧酸的支链脂肪酸酯；以及至少2重量％的矿物颗粒，所述矿物颗粒具有涂覆于其表面的淀粉涂层。
Description
技术领域
本发明涉及局部用防晒剂组合物，所述防晒剂组合物具有能成功涂敷于润湿皮肤的能力。
背景技术
常规的防晒产品一般采取溶解、乳化或分散于媒介物中的紫外滤光化合物和/或颗粒状紫外屏蔽化合物(统称为“防晒活性物质”)的形式，所述媒介物局部涂敷于皮肤上。防晒活性物质通常通过包括于媒介物中的辅助合物和其他成分，在皮肤上形成薄的、通常防水的保护层。
申请人已认识到，虽然典型的防晒产品在涂敷于干燥皮肤时可有效提供持久耐用的保护屏障，但在涂敷于汗湿或其上有残余水分的皮肤时，通常结果并非如此。事实上，将常规的防晒产品涂敷于润湿的皮肤时，其趋势是稀释防晒活性物质、弄污皮肤、形成不完整的薄膜，该薄膜通常从皮肤剥落或剥离，和/或呈现出糊状的白色外观。发明人已发现，当组合物本身包含水分时，这种不期望的变白问题尤其突出。
其他人已设想将防晒剂涂敷于润湿皮肤上的解决方案，在皮肤上可能存在残余水分的情况下，使用油包水型乳化剂进行“自乳化”。然而，申请人已认识到现有技术的“润湿皮肤”防晒产品仍存在严重的美学和性能问题。因此，申请人现已确定出新型组合物，该组合物可持久和舒适地涂敷于润湿皮肤上，并且所得薄膜能够保护皮肤不受破坏性紫外线辐射的伤害。
发明内容
本发明涉及防晒剂组合物，其包括分散于连续水相中的不连续油相、约10重量％或更多的有机紫外线滤光剂、水不溶性的低挥发性C2-C8液态有机硅、多质子羧酸的支链脂肪酸酯；和约2重量％或更多的矿物颗粒(包括涂覆于其表面的淀粉涂层)。
具体实施方式
如本文所用，“美容上可接受的”意指适用于接触组织(如皮肤)而无不当的毒性、不相容性、不稳定性、过敏、变应性反应等等。本文中的所有百分比均为分别按组合物、油相或水相或矿物颗粒的总浓度计的重量百分比。
本发明的组合物包括不连续油相和连续水相。本领域的普通技术人员将会理解，所谓“不连续油相”其意指在水相中稳定的紧密混合的有机疏水化合物的在物理上独特的聚集体。除了其他疏水性化合物以外，可包括于油相中的化合物包括(例如)有机紫外线滤光剂、液态有机硅、多元羧酸的脂肪酸酯、油胶凝剂和蜡。油相在组合物中的浓度可为约10％至约80％，如约20％至约70％，如约30％至约60％，如约40％至约60％。
所谓“连续水相”其意指水和其他任选成分的在物理上独特的聚集体，所述任选成分通常是亲水性的并且与水紧密混合。适用于水相的成分包括(例如)水、诸如氯化钠之类的溶解盐、水溶性表面活性剂、水溶性防腐剂和染料、螯合剂、pH调节剂和缓冲剂(例如柠檬酸、氢氧化钠、碳酸氢盐等)、水溶性生物活性化合物、丙三醇、二醇类等。在本发明的某些实施例中，以组合物的重量计，水相在组合物中的浓度为20％至约90％，如约30％至约80％，如约35％至约65％，如约40％至约65％。在某些实施例中，水相的浓度大于油相的浓度。
在某些实施例中，不连续油相可基本上均匀地分散于水相中并且可达到相稳定。所谓“相稳定”其意指在40℃下暴露两周之后，没有可感知的油相从水相的分离或沉降。在某些实施例中，在40℃下暴露六周之后，或在其他实施例中，在40℃下暴露三个月之后，没有可感知的油相从水相的分离或沉降。在此类相稳定组合物中，不连续油相可在连续水相中稳定化，从而离散的油相得以存在，使得大多数粒子的粒度为约0.2微米至约10微米，更优选为约0.5微米至5微米，最优选为约0.75微米至5微米。在其他实施例中，组合物可以是在使用前通过对组合物进行轻度到中度搅拌油相即可分散于水相中的这样一种组合物。
本发明的组合物包括有机紫外线滤光剂。本发明中可用的有机紫外线滤光剂是美容上可接受的化合物，该化合物可吸收紫外范围内的辐射，并且通常可溶解于一种或多种有机烃类溶剂。有机紫外线滤光剂可吸收紫外光谱的某一部分(290nm-400nm)内的辐射，并且对上面定义的紫外光谱内的至少一个波长的消光系数可为至少约1000mol-1cm-1，例如大于10,000或100,000或1,000,000mol-1cm-1。
有机紫外线滤光剂的例子包括但不限于3-亚苄基樟脑，尤其是3-亚苄基降樟脑及其衍生物，例如3-(4-甲基亚苄基)樟脑；4-氨基苯甲酸衍生物，尤其是4-(二甲基氨基)苯甲酸-2-乙基己酯、4-(二甲基氨基)苯甲酸-2-辛酯和4-(二甲基氨基)苯甲酸戊酯；肉桂酸酯，尤其是4-甲氧基肉桂酸-2-乙基己酯、4-甲氧基肉桂酸丙酯、4-甲氧基肉桂酸异戊酯、2-氰基-3，3-苯基肉桂酸-2-乙基己酯(氰双苯丙烯酸辛酯)；水杨酸酯，即水杨酸-2-乙基己酯、水杨酸-4-异丙基苄酯、水杨酸高薄荷酯；二苯甲酮衍生物，尤其是2-羟基-4-甲氧基二苯甲酮、2-羟基-4-甲氧基-4‘-甲基二苯甲酮、2，2‘-二羟基-4-甲氧基二苯甲酮；亚苯甲基丙二酸酯，尤其是4-甲氧基亚苯甲基丙二酸二-2-乙基己酯；三嗪衍生物，例如2，4，6-三苯胺基-(对-羰-2‘-乙基-1‘-己氧基)-1，3，5-三嗪和辛基三嗪酮；或苯甲酸，4，4′-[[6-[[[(1，1-二甲基乙基)氨基]羰基]苯基]氨基]-1，3，5-三嗪-2，4-二基]二亚氨基]双-，双(2-乙基己基)酯(UVASORBHEB)；丙烷-1，3-二酮，例如1-(4-叔丁基苯基)-3-(4’-甲氧基苯基)丙烷-1，3-二酮；酮三环(5.2.1.0)癸烷衍生物；苯甲酰甲烷衍生物，例如1-(4’-叔丁基苯基)-3-(4’-甲氧基苯基)丙烷-1，3-二酮、4-叔丁基-4’-甲氧基二苯甲酰基甲烷(PARSOL 1789)、1-苯基-3-(4’-异丙基苯基)-丙烷-1，3-二酮、苯甲酸2-(4-二乙基氨基-2-羟基苯甲酰基)-苯甲酸己酯的衍生物(UVINULA+)或1H-苯并咪唑-4，6-二磺酸、2，2′-(1，4-亚苯基)双-，二钠盐(NEOHELOPAN AP)；以及苯并三唑，尤其是称为2，2′-亚甲基-双-(6-(2H-苯并三唑-2-基)-4-(1，1，3，3-四甲基丁基)-苯酚)[INCI名称：双辛基三唑]的苯并三唑衍生物，其可以商品名TINOSORB M从CIBA Chemicals商购获得。另一种可用的苯并三唑衍生物为2-(2H-苯并三唑-2-基)-4-甲基-6-[2-甲基-3-[1，3，3，3-四甲基-1-[(三甲基甲硅烷基)氧基]二硅氧烷基]丙基]-苯酚(CAS-No.：155633-54-8)，其INCI名称为甲酚曲唑三硅氧烷并可以商品名MEXORYL XL得自Chimex。同样适用的为不对称取代的三嗪衍生物，以及可以商品名TINOSORB S从CIBA商购获得的2，4-双-{[4-(2-乙基己氧基)-2-羟基]-苯基}-6-(4-甲氧苯基)-1，3，5-三嗪(INCI：非均三嗪(anisotriazine))。
在一个实施例中，有机紫外线滤光剂选自氰双苯丙烯酸辛酯、苯并三唑、非均三嗪、水杨酸酯、肉桂酸酯和苯乙酮衍生物。
有机紫外线滤光剂在组合物中的浓度为约10重量％或更大，如约10重量％至约40重量％，如约10重量％至约35重量％，如约15重量％至约35重量％，如约20重量％至约35重量％。
本领域技术人员将容易认识到，术语“有机紫外线滤光剂”并不包括紫外线屏蔽粒子(“UV屏蔽粒子”)，这些粒子通常至少在一定程度上用于散射紫外线辐射。例子包括无机氧化物，包括二氧化钛、氧化锌、氧化铁、氧化硅(silicone oxide)；或其他金属(例如过渡金属，如晶态过渡金属)的氧化物。UV屏蔽粒子通常为尺寸(如直径)为约0.1微米至约10微米的固体粒子。虽然在本发明的某些实施例中，本发明的组合物中可任选包含UV屏蔽粒子，但在某些其他实施例中，则不包含UV屏蔽粒子。对于那些包含UV屏蔽粒子的实施例，UV屏蔽粒子在组合物中的浓度可为约0.1％至约10％，如约0.5％至约5％，如约0.5％至约2％。
本发明的组合物包含水不溶性的低挥发性C2-C8液态有机硅。所谓“低挥发性”其意指化合物的闪点高于约105℃，如高于约150℃，如高于约200℃。所谓“液态有机硅”其意指具有至少一种熔点低于25℃的硅氧烷(Si-O-Si键)的化合物。在某些实施例中，液态有机硅不溶于水，而在某些实施例中，液态有机硅可溶于异丙醇。液态有机硅可具有包括一个或多个如下单元的结构：
-[CH3-SiO-CnH2n-CH3]-
其中n为2至8，如2至4。一个特别适合的例子是其中n＝2的化合物，其可以商品名SILWAX D02(INCI：乙基聚甲基硅氧烷)得自Siltech(Dacula，Georgia)。
水不溶性的低挥发性C2-C8液态有机硅通常用于为皮肤表面形成的薄膜提供塑性，以及用于防止组合物在接触皮肤上的水时变白(例如通过增加所得薄膜的折射率)，否则该组合物可能会变白。组合物中存在的非挥发性液态有机硅的浓度可为约0.5％至约10％，或约1％至约6％，或约2％至约4％。
本发明的组合物包括多质子羧酸的支链脂肪酸酯(“BFEPCA”)。多质子羧酸的支链脂肪酸酯的熔点低于25℃，不溶于水，可溶于异丙醇。在一个值得注意的实施例中，BFEPCA是多质子酸与C10-C30脂肪酸(如C12-C22脂肪酸)的反应产物。所述脂肪酸可以是支链的。多质子酸可选自柠檬酸、抗坏血酸、磷酸和硫酸。在一个实施例中，多质子酸为柠檬酸或抗坏血酸。柠檬酸尤其值得注意。
例如，BFEPCA可每分子具有五个或更多个酯基。BFEPCA的一个合适的例子为辛基十二烷醇柠檬酸聚酯，其以商品名COSMOSURF CE-100得自SurfaTechCorporation/Siltech Corporation(Dacula，Georgia)。
PFECPA有助于组合物在形成薄膜的过程中排除水分，还能在薄膜形成后起到防止薄膜剥落和抵抗水降解的作用。
存在于组合物中的PFECPA的浓度可为约2％至约40％，或约4％至约25％，或约8％至约18％。在某些实施例中，PFEPCA和液态有机硅以PFEPCA与液态有机硅比率为约1.5至约8(如约2至约4)存在。
本发明的组合物包括至少部分涂覆有淀粉的矿物颗粒。所谓“颗粒”其意指通常不溶于水的细分固体，如平均粒度在约0.1微米至约20微米范围内的固体。矿物颗粒包括矿物部分和涂料部分，所述矿物部分为例如包括多种硅石、氧化物和/或硅铝酸盐中任意一者的矿物部分；所述涂料部分施用到矿物表面以致至少部分涂覆矿物部分。涂料可以是连续的，基本上覆盖矿物部分的全部表面，或者可以是不连续的，覆盖矿物部分表面的大部分，而非全部。涂料部分包含淀粉。
淀粉可衍生自诸如玉米、小麦、水稻、木薯、马铃薯、西米等之类的植物，包括此类淀粉的蜡质形式(含少于5％的直链淀粉)、高淀粉酶淀粉(含有超过40％的直链淀粉)以及链长经修改的那些，和/或它们的组合。在某些优选的实施例中，淀粉为米淀粉。
矿物部分可以约80％至约98％，如约80％至约97％，如约85％至约96％的矿物颗粒重量百分比存在。涂料部分可以约2％至约20％，如约3％至约20％，如约4％至约15％的矿物颗粒重量百分比存在。
在某些实施例中，矿物颗粒的矿物油吸附容量为约20ml/100g或更高，如约100ml/100g或更高，如约200ml/100g或更高。矿物油吸附容量通过以下方法测定：将3-5克测试样品置于玻璃板上，一次滴加一滴矿物油，并用刮刀混合。当样品形成不会破裂或分离的非常粘的糊剂时，表明已达到终点。糊剂应当可以用刮刀进行滚压而不会分离。重复进行三次测试。
可通过本领域技术人员已知的多种方法的任意一种来制备矿物颗粒。合适的方法包括通过将淀粉喷涂在矿物颗粒表面并随后进行干燥来用淀粉涂覆矿物颗粒。
在一个示例性方法中，将水和米淀粉混合在一起并加热足以使淀粉胶凝化的一段时间。将胶凝化的淀粉混合物在高压下喷涂至直径在约1微米至约10微米范围内的多孔球形硅石粒子上。喷涂过程中，在高强度、高速搅拌器中搅拌硅石，以确保喷涂均匀。然后将硅石和胶凝化淀粉的混合物在真空下干燥足以除去水的一段时间。可选择硅石及其表面涂覆的淀粉的相对比例，以实现约95∶5的硅石与淀粉的重量比。
由于矿物颗粒不溶于油相或水相，因此该颗粒通常以离散的分散相存在于组合物中，即不为油相或水相的一部分。
矿物颗粒在组合物中的量为约2重量％或更多。在某些实施例中，矿物颗粒以约4％或更多，如约4％至约10％，或约4％至约8％的浓度存在。
本发明的组合物可包含油胶凝剂。所谓“油胶凝剂”其意指能够与矿物油或聚二甲基硅氧烷形成凝胶的化合物。具体地讲，当将油胶凝剂与矿物油或聚二甲基硅氧烷混合至油胶凝剂的浓度为约0.25重量％至2.0重量％时，所得混合物的屈服应力至少为约5帕斯卡(Pa)，如至少为约10Pa，如约10Pa至约1100Pa。
合适的油胶凝剂包括多种脂肪酸的甘油酯，例如碳链长度至少为C16的脂肪酸甘油酯。合适的例子为以商品名COMPRITOL 888由Gattefosse(France)出售的二十二烷酸(C22)的单甘油酯、双甘油酯和甘油三酯的混合物。
其他合适的油胶凝剂包括硅氧烷和具有亲水部分的单体的共聚物，例如硅氧烷和具有烷氧基部分的单体的共聚物。合适的例子包括时常被归类为有机硅包水型(water-in-silicone)乳化剂的材料。合适的例子为溶于环戊硅氧烷溶剂中出售的PEG/PPG-19/19聚二甲基硅氧烷，可以商品名DowCorning BY-11030得自Dow Corning(Midland，Michigan)。
其他合适的油胶凝剂包括诸如乙烯、丙烯、丁烯和/或苯乙烯之类的单体的共聚物，例如乙烯、丙烯和苯乙烯的三元共聚物，以及丁烯、乙烯和苯乙烯的三元共聚物。此类三元共聚物以商品名VERSAGEL F-1000得自Penreceo(Los Angeles，California)。
其他特别合适的油胶凝剂包括乙基纤维素，这是一种包含长链聚合物的纤维素乙基醚，所述长链聚合物由通过缩醛键连接在一起的脱水葡萄糖单元组成。适当形式的乙基纤维素可作为与丁二醇的椰油酸单酯和二酯以及异硬脂醇(脂肪醇)的混合物获得。该混合物以“EMULFREE CBG”得自Gattefosse(Paris，France)。
本发明的组合物可包括成膜聚合物，以加快薄膜形成和提供一定的防水性。所谓“成膜聚合物”其意指这样的聚合物，在该聚合物溶解于组合物中时，将该组合物涂布到例如光滑玻璃上，并让液体媒介物蒸发时，会形成连续性或半连续性薄膜。如此，该聚合物应当在玻璃上以如下方式干燥，其中在该聚合物铺展开的区域上其应主要是连续的，而不是形成多个离散的岛状结构。一般来讲，根据本文所述的本发明实施例的通过在皮肤上涂敷组合物而形成的薄膜的平均厚度小于约100微米，如小于约50微米。
合适的成膜聚合物包括天然的聚合物，如多糖或蛋白质和诸如聚酯、聚丙烯酸类、聚氨酯、乙烯基聚合物、聚磺酸酯、聚脲、聚噁唑啉等之类的合成聚合物。成膜聚合物的具体例子包括(例如)具有疏水基团的丙烯酸类均聚物或共聚物，如丙烯酸酯/辛基丙烯酰胺共聚物，包括得自AkzoChemical(Bridgewater，New Jersey)的DERMACRYL 79；可以X-22-8247D得自Shin-Etsu(Japan)的聚二甲基硅氧烷/丙烯酸酯聚二甲基硅氧烷共聚物；可以COSMEDIA DC得自Cognis Corporation(Ambler，Pennsylvania)的氢化二聚亚油醇/碳酸二甲酯共聚物；乙烯基吡咯烷酮和长链α烯烃的共聚物，如可以GANEX V220从ISP Specialty Chemicals(Wayne，New Jersey)商购获得的那些；可以GANEX WP660同样得自ISP的乙烯基吡咯烷酮/三十碳烯共聚物；水分散性聚酯，包括诸如可以EASTMAN AQ 38S从EastmanChemical商购获得的那些之类的磺基聚酯。在某些实施例中，成膜聚合物为水不溶性的，但在暴露于碱性时可使其溶解，从而在使用肥皂洗涤时有利于将其从皮肤上去除。
成膜聚合物在组合物中的量可为约0.25％至约15％，或约0.5％至约10％，或约1％至约3％。
在某些实施例中，组合物包含蜡。所谓蜡是指一种或多种疏水化合物，其熔点在30℃至120℃的范围内，如在45℃至100℃的范围内。在一个实施例中，蜡组分包括熔点为约75℃至100℃的蜡化合物。
所谓“额外的疏水化合物”其意指包含满足以下三个标准中的一个或多个的疏水部分的化合物：(a)具有至少六个碳原子的碳链(其中该六个碳原子中没有一个是羰基碳)，或具有直接键合到其上的亲水部分(定义如下)；(b)具有两个或更多个烷基甲硅烷氧基；或(c)链中具有两个或更多个氧基亚丙基基团。疏水部分可包括直链的、环状的、芳族的、饱和或不饱和的基团。该疏水化合物并非两亲的，并且此类化合物不包含亲水部分，如为极性的阴离子、阳离子、两性离子或非离子基团，这些基团包括硫酸根、磺酸根、羧酸根、磷酸根、膦酸根、铵(包括单烷基铵、二烷基铵和三烷基铵物质)、吡啶咪唑啉脒聚(乙烯亚胺)、烷基磺酸铵、烷基羧酸铵、两性乙酸盐和聚(乙烯氧基)磺酰基部分。在某些实施例中，疏水化合物不包含羟基部分。
合适的蜡包括任何多种烃类(直链或支链烷烃或烯烃、酮、二酮、伯醇或仲醇、醛、甾醇酯、链烷酸、萜烯、单酯)，如碳链长度在C12至C38范围的烃类。同样合适的还有二酯或其他支链酯。在一个实施例中，该化合物为醇酯(甘油或非甘油)和C18或更高级的脂肪酸。
非限制性例子包括多种天然蜡中的任一种，包括莲花蜡(lotus wax)(例如可得自Deveraux Specialties(Silmar，California)的莲花蜡(DeverauxSpecialties Floral Wax))；蜂蜡(例如可得自Strahl and Pitsch(WestBabylon，New York)的白蜂蜡SP-422P(White Beeswax SP-422P))、虫蜡、抹香鲸油、羊毛脂、植物蜡如巴西棕榈蜡、霍霍巴油、小烛树蜡；矿物蜡如石蜡；以及合成蜡如棕榈酸鲸蜡酯、棕榈酸月桂酯、十六十八醇硬脂酸酯和聚乙烯蜡(例如可得自New Phase Technologies(Sugar Land，Texas)的PERFORMALENE 400，其分子量为450，熔点为84℃)；以及硅蜡如C30- 45烷基聚甲基硅氧烷和C30-45烯烃(例如可得自Dow Corning(Midland，Michigan)的Dow Corning AMS-C30，其熔点为70℃)。在某些实施例中，蜡组分包括高熔点的甘油酯，如单硬脂酸甘油酯。
蜡在组合物中的量可为约0.1％至约5％，或约0.1％至约2％，或约0.1％至约1％。
本发明的组合物可包含烷基改性的有机硅聚合物。分散的烷基改性的有机硅聚合物可以是不溶于异丙醇的以及不溶于水的。烷基改性的有机硅聚合物通常包括C8-C30直链或环状的、饱和或不饱和的烷基，如C12-C22烷基。
烷基改性的有机硅通常起到降低表面张力、改善水排除以及减少变白现象的作用。充分分散于诸如异丙醇之类的溶剂中的合适的烷基改性的有机硅聚合物的例子包括鲸蜡基聚二甲硅氧烷和双乙烯基聚二甲基硅氧烷的共聚物，如可从SilTech(Dacula，Georgia)商购获得的SILWAX CR-5016。对于其中烷基改性的有机硅聚合物不溶于油相或水相的实施例，烷基改性的有机硅聚合物可作为离散的分散相存在于组合物中，即不为油相或水相的一部分。
分散的烷基改性的有机硅聚合物在组合物中的量可为约0.1％至约1％，或约0.1％至约0.5％，或约0.1％至约0.25％。
各种其他美容上可接受的成分中的任一种可以不致抵消各种其他成分的效果的量包括在组合物中。例如，诸如植物、动物或矿物起源的油(包括润肤性酯和甘油三酯)、香料、染料、防腐剂、皮肤有益剂、光稳定剂、抗氧化剂、水相胶凝剂(如双硬脂酸甘油酯或疏水改性丙烯酸树脂或其他增稠聚合物)、中和剂(如三乙醇胺、氢氧化钠等)之类的成分。
其他成分可以(例如)小于约10％，如小于约5％，如小于约2％，如小于约1％的总浓度包括在内。
实例
以下非限制性实例将进一步说明受权利要求书保护的发明：
实例I：本发明实例的制备
制备下列本发明组合物：
1 79.8％的辛基十二醇柠檬酸聚酯(COSMOSURF CE-100)、20％的乙基聚甲基硅氧烷(SILWAX D02)和0.2％的鲸蜡基聚二甲硅氧烷和双乙烯基聚二甲基硅氧烷的共聚物(SILWAX CR-5016)的共混物，各成分均得自SilTech。
通过以下方法制备实例：首先在容器中装入水、PEMULEN TR-2、乙二胺四乙酸二钠、甘草酸二钾和氯苯甘油醚来制备初级水相混合物，然后将该混合物加热至80℃并混合直至均相。就实例1、4、5而言，接着加入苯氧基乙醇(胶凝剂)并将混合物再次混合直至均相。在第二个容器中，通过共混有机紫外线滤光剂和表1中所列出的其他成分(一直到Sunspheres并包括Sunspheres)来制备油相混合物。将水相混合物和油相混合物共混5分钟，然后匀化3分钟以形成初级乳状液。然后通过将该初级乳状液冷却至65℃，加入水和三乙醇胺，然后混合至均匀，来中和初级乳状液。让中和的乳状液冷却至40℃并加入苄醇和芳香剂。然后边搅拌边缓慢加入矿物颗粒直至冷却至30℃-32℃。将该乳状液再匀化1分钟，添加任何余量的任何水。就实例5而言，在最初对容器进行装料时扣除配方中存在的总水量的6.5％，在乳化结束后加入。
评估实例在40℃下的稳定性和在皮肤上的不利变白现象。通过这样来评价稳定性(对预计储存寿命的加速测量)：将组合物置于40℃的环境下，然后观察任何可测量的脱水收缩，例如乳化组合物顶部处可见的可测量量的油相(液体)。在40℃下三个月的稳定性通常相当于产品3年的储存寿命，而在40℃下两个月的稳定性通常相当于2年的储存寿命。
皮肤上的变白现象通过这样来评价：将人受试者的手臂浸入水中大约1-2分钟，然后将本发明的组合物涂敷于该手臂的润湿区域，将该组合物摩擦进皮肤中。组合物以通常有效为该皮肤区域提供连续薄膜的量施用，即男性的整个手臂需要约4克，或女性的整个手臂需要约3克，同一手臂上通常为0.5g/15cm2。
实例1在涂敷于皮肤时仅显示出最低程度的可接受量的变白现象，并且在40℃下保持相稳定3个月。实例5在皮肤上未显示出可辨别的变白现象，并且在40℃下稳定3个月。实例2和实例4在皮肤上显示出最低程度的但可接受的变白现象，并且在40℃下稳定2周。实例3在皮肤上为显示出可辨别的变白现象。
前述结果表明，根据本发明的组合物在涂敷于润湿皮肤后，出人意料地几乎不产生变白现象，甚至无变白现象。前述结果还表明，取决于具体的配方，通过(例如)如下方法可实现不同程度的稳定性：(a)包括油胶凝剂如COMPRITOL，或(b)在乳化后但在矿物颗粒之前加入至少5％(总组合物的百分比)的水。对于高含量的至少部分涂覆有淀粉的矿物颗粒，通过加入油胶凝剂，包括进较高含量的水，和/或通过遵照扣留至少5％的水直至乳化后，但在矿物颗粒之前的工序，可提高稳定性。一旦获得本文公开内容的有益效果之后，本领域技术人员将容易理解各种因素和步骤，以便调整此类组合物的稳定性。
实例2：SPF
根据食品和药物监督管理局于1999年5月21日的《联邦公报》第64卷第98期第27666-27693页(Federal Register Volume 64，Number 98，27666-27693)上所发布的“Sunscreen Drug Products for Over-The-Counter HumanUse；Final Monograph”，使用常规的体内静态防晒因子(SPF)测试方法来测试实例1和实例5中的SPF。请参见第2至3页。该测试包括测量在皮肤浸入水中共80分钟前后干燥皮肤上的SPF。实例1显示浸水前干燥皮肤上的SPF值为92.5，而浸水后为91.85。实例5显示浸水前干燥皮肤上的SPF值为55.2，而浸水后为55.0。
相同的组合物用相同方法测试，不同的是将组合物在浸水后涂敷于润湿皮肤。当浸水后涂敷于润湿皮肤时，该组合物显示出的SPF值分别为86.66和47.8。这些结果出人意料地表明，本发明的组合物在涂敷于润湿皮肤时，其SPF值与涂敷于干燥皮肤时相比仅降低少量。
Claims (11)
1.一种组合物，所述组合物包含：
连续水相，
分散于所述连续水相中的不连续油相，
10重量%或更多的有机紫外线滤光剂，
水不溶性的C2-C8液态有机硅，
多质子羧酸的支链脂肪酸酯；和
2重量%或更多的矿物颗粒，所述矿物颗粒包含矿物部分和淀粉涂层部分，所述淀粉涂层部分涂覆于矿物部分的表面并至少部分覆盖所述矿物部分。
2.根据权利要求1所述的组合物，其中所述矿物部分包含硅石。
3.根据权利要求1所述的组合物，其中所述矿物颗粒包含80重量%至98重量%的所述矿物部分和2重量%至20重量%的所述淀粉涂层部分。
4.根据权利要求1所述的组合物，所述组合物包含4重量%至10重量%的所述矿物颗粒。
5.根据权利要求1所述的组合物，其中所述多质子羧酸的支链脂肪酸酯包含辛基十二醇柠檬酸聚酯。
6.根据权利要求1所述的组合物，其中所述水不溶性C2-C8液态有机硅包含乙基聚甲基硅氧烷。
7.根据权利要求1所述的组合物，其中所述矿物颗粒的矿物油吸附容量为20ml/100g或更大。
8.根据权利要求1所述的组合物，其中所述有机紫外线滤光剂选自氰双苯丙烯酸辛酯、苯并三唑、非均三嗪、水杨酸酯、肉桂酸酯、1-(4-叔丁基苯基)-3-(4’-甲氧基苯基)丙烷-1,3-二酮、4-叔丁基-4’-甲氧基二苯甲酰基甲烷和1-苯基-3-(4’-异丙基苯基)-丙烷-1,3-二酮。
9.根据权利要求4所述的组合物，其中所述矿物颗粒包含硅石，所述硅石具有涂覆于其涂层的米淀粉，并且其中所述组合物还包含胶凝剂。
10.根据权利要求9所述的组合物，所述组合物在40℃下的稳定性为3个月。
11.根据权利要求1所述的组合物，所述组合物在40℃下的稳定性为2周。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/875,163 US8236287B2 (en) | 2010-09-03 | 2010-09-03 | Sunscreen compositions |
| US12/875,163 | 2010-09-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102406554A CN102406554A (zh) | 2012-04-11 |
| CN102406554B true CN102406554B (zh) | 2014-10-01 |
Family
ID=44674416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110270912.7A Active CN102406554B (zh) | 2010-09-03 | 2011-09-02 | 防晒剂组合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8236287B2 (zh) |
| EP (1) | EP2425810B8 (zh) |
| KR (1) | KR101870614B1 (zh) |
| CN (1) | CN102406554B (zh) |
| AU (1) | AU2011218694B2 (zh) |
| BR (1) | BRPI1105913B8 (zh) |
| ES (1) | ES2700504T3 (zh) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102013203045A1 (de) * | 2013-02-25 | 2014-08-28 | Beiersdorf Ag | Kosmetisches Sonnenschutzmittel mit reduziertem Weißeleffekt |
| DE102013203017A1 (de) * | 2013-02-25 | 2014-08-28 | Beiersdorf Ag | Sonnenschutzmittel mit Ethylmethicon |
| BR112015021640A2 (pt) * | 2013-03-08 | 2017-07-18 | Unilever Nv | composição de cuidados pessoais fotoprotetora, método para fornecer um spf aprimorado à pele e uso de uma composição |
| BR112015029650B1 (pt) * | 2013-05-30 | 2020-06-30 | L'oreal | composição cosmética, métodos cosméticos não terapêuticos e usos de uma composição cosmética |
| EP2853255B1 (en) | 2013-09-27 | 2018-11-28 | HallStar Beauty and Personal Care Innovations Company | Method of formulating a personal care product with substantially no whitening effect when applied on wet skin and compositions thereof |
| US9579276B2 (en) * | 2013-12-12 | 2017-02-28 | L'oreal | Clear sunscreen composition for application onto wet or dry skin |
| JP6632977B2 (ja) * | 2013-12-18 | 2020-01-22 | ロレアル | 低量のアルコールを含むピッケリングエマルションの組成物 |
| CN106659646B (zh) * | 2014-07-16 | 2022-07-01 | 莱雅公司 | 具有油珠的可喷射的防晒组合物 |
| FR3037243B1 (fr) * | 2015-06-11 | 2018-11-16 | L'oreal | Composition comprenant un filtre uv, un polymere hydrophile reticule anionique, un tensioactif ayant une hlb inferieure ou egale a 5 et un copolymere silicone |
| US11291621B2 (en) * | 2019-10-04 | 2022-04-05 | Johnson & Johnson Consumer Inc. | Transparent sunscreen composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050276763A1 (en) * | 2004-05-19 | 2005-12-15 | Beiersdorf Ag | Emulsion concentrate containing water-soluble and oil-soluble polymers |
| CN101129302A (zh) * | 2006-06-22 | 2008-02-27 | 莱雅公司 | 硅氧烷物质的凹面或环形颗粒作为使其可能增加防晒因子的试剂的化妆品应用;包含它们的水性光防护组合物 |
| CN101663020A (zh) * | 2007-04-04 | 2010-03-03 | 巴斯夫欧洲公司 | 基于无机-有机混合体系的uv光保护制剂 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4551330A (en) | 1983-06-30 | 1985-11-05 | Helene Curtis Industries, Inc. | Skin and hair conditioner compositions and conditioning method |
| GB8914905D0 (en) | 1989-06-29 | 1989-08-23 | Unilever Plc | Cosmetic composition |
| GB8925473D0 (en) | 1989-11-10 | 1989-12-28 | Unilever Plc | Sunscreen compositions |
| US5118507A (en) | 1991-06-25 | 1992-06-02 | Elizabeth Arden Co., Division Of Conopco, Inc. | Silicone based cosmetic composition |
| US6197281B1 (en) | 1997-06-04 | 2001-03-06 | Ernest G. Stewart | Wet appliable, instant protection sunscreen and makeup and method of use |
| US5962018A (en) | 1998-04-28 | 1999-10-05 | Avon Products, Inc. | Method of treating the skin with organic acids in anhydrous microsphere delivery systems |
| CN1181805C (zh) * | 1999-12-03 | 2004-12-29 | 卡尔贡公司 | 改性淀粉溶液及其在个人护理中的应用 |
| DE10062611A1 (de) | 2000-12-15 | 2002-06-27 | Merz & Co Gmbh & Co | Hautöle aus öllöslichen Komponenten und W/O-Emulgatoren mit einem HLB-Wert von 2-6 sowie wahlweise einem oder mehreren üblichen Zusatzstoffen, Verfahren zu deren Herstellung und ihre Verwendung |
| DE10162697A1 (de) * | 2001-12-19 | 2003-07-03 | Cognis Deutschland Gmbh | Kosmetische und/oder pharmazeutische Sonnenschutzmittel |
| DE10162844A1 (de) * | 2001-12-20 | 2003-07-03 | Beiersdorf Ag | Kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Bis-Resorcinyltriazinderivaten und Benzoxazol-Derivaten |
| KR20050019751A (ko) * | 2002-06-17 | 2005-03-03 | 더 프록터 앤드 갬블 캄파니 | 피지 및 땀 흡수용 파운데이션 키트 및 관련 다단계 방법 |
| DE60333873D1 (de) | 2003-10-03 | 2010-09-30 | Green Meadows Res Llc | Zubereitungen die Lotusextrakte und Methyldonatoren enthalten |
| US7276553B2 (en) | 2004-12-10 | 2007-10-02 | Avon Products, Inc. | Aesthetic, stable chromatic emulsions |
| CN101384239A (zh) * | 2005-12-21 | 2009-03-11 | 先灵-普劳健康护理产品公司 | Uv辐射保护剂组合物 |
| EP2023889A2 (en) | 2006-05-31 | 2009-02-18 | Neutrogena Corporation | Clear sunscreen compositions |
| US20090035234A1 (en) * | 2007-07-31 | 2009-02-05 | Kimberly-Clark Worldwide, Inc. | Continuous spray sunscreen compositions |
| US8877166B2 (en) * | 2008-10-14 | 2014-11-04 | Cockerell Dermatology Development, Ltd. | SPF liquid cleansing compositions |
| FR2943541B1 (fr) | 2009-03-31 | 2011-04-22 | Oreal | Composition filtrante fluide anhydre oleoalcoolique comprenant un polycondensat polyamide lipophile |
-
2010
- 2010-09-03 US US12/875,163 patent/US8236287B2/en active Active
-
2011
- 2011-08-31 AU AU2011218694A patent/AU2011218694B2/en active Active
- 2011-09-02 CN CN201110270912.7A patent/CN102406554B/zh active Active
- 2011-09-02 KR KR1020110088837A patent/KR101870614B1/ko active IP Right Grant
- 2011-09-02 ES ES11179856T patent/ES2700504T3/es active Active
- 2011-09-02 EP EP11179856.7A patent/EP2425810B8/en active Active
- 2011-09-02 BR BRPI1105913A patent/BRPI1105913B8/pt active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050276763A1 (en) * | 2004-05-19 | 2005-12-15 | Beiersdorf Ag | Emulsion concentrate containing water-soluble and oil-soluble polymers |
| CN101129302A (zh) * | 2006-06-22 | 2008-02-27 | 莱雅公司 | 硅氧烷物质的凹面或环形颗粒作为使其可能增加防晒因子的试剂的化妆品应用;包含它们的水性光防护组合物 |
| CN101663020A (zh) * | 2007-04-04 | 2010-03-03 | 巴斯夫欧洲公司 | 基于无机-有机混合体系的uv光保护制剂 |
Non-Patent Citations (2)
| Title |
|---|
| Cosmosurf CE Series;Surfatech Corporation;《http://www.surfatech.com/pdfs/TD%20Cosmosurf%20CE%20Series.pdf》;20090109;第1页第1-5行,第2页第2-4行,表格LR1220 * |
| Surfatech Corporation.Cosmosurf CE Series.《http://www.surfatech.com/pdfs/TD%20Cosmosurf%20CE%20Series.pdf》.2009,第1页第1-5行,第2页第2-4行,表格LR1220. |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI1105913B8 (pt) | 2022-08-30 |
| CN102406554A (zh) | 2012-04-11 |
| EP2425810B8 (en) | 2019-01-02 |
| ES2700504T3 (es) | 2019-02-18 |
| AU2011218694B2 (en) | 2014-03-13 |
| BRPI1105913A2 (pt) | 2013-01-15 |
| EP2425810B1 (en) | 2018-10-24 |
| EP2425810A2 (en) | 2012-03-07 |
| KR20120023580A (ko) | 2012-03-13 |
| KR101870614B1 (ko) | 2018-06-26 |
| US8236287B2 (en) | 2012-08-07 |
| EP2425810A3 (en) | 2016-01-06 |
| AU2011218694A1 (en) | 2012-03-22 |
| BRPI1105913B1 (pt) | 2018-05-29 |
| US20120058192A1 (en) | 2012-03-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102406554B (zh) | 防晒剂组合物 | |
| CN102753140B (zh) | 护肤组合物 | |
| Gilbert et al. | Percutaneous absorption of benzophenone-3 loaded lipid nanoparticles and polymeric nanocapsules: A comparative study | |
| CN102770183A (zh) | 包含紫外辐射吸收性聚合物的防晒剂组合物 | |
| CN106619147A (zh) | 泡腾性防晒剂组合物 | |
| CN103221020A (zh) | 包含二苯甲酰甲烷化合物和有色颜料的无水组合物 | |
| JP2016124817A (ja) | 二層型化粧料 | |
| CN105534733A (zh) | 防晒化妆品 | |
| EA017111B1 (ru) | Монокристаллический пластинчатый сульфат бария в косметических композициях | |
| JP2022511674A (ja) | ミネラル日焼け止め組成物 | |
| WO2013069723A1 (ja) | 水中油型乳化日焼け止め化粧料 | |
| CN104427966A (zh) | 包含紫外线辐射吸收性聚酯的防晒剂组合物 | |
| CN106132386A (zh) | 局部组合物 | |
| KR101242960B1 (ko) | 하이브리드 티타늄디옥사이드 및 이를 포함하는 자외선 차단용 화장료 조성물 | |
| KR102587916B1 (ko) | 유기계 자외선 차단제를 포함하는 실리콘중수 타입의 화장료 조성물 | |
| CN103027849A (zh) | 局部用防晒组合物 | |
| BR102012024490A2 (pt) | composição de filtro solar tópica | |
| TW202108117A (zh) | 含有雙乙基己氧基苯酚甲氧基苯基三嗪之複合配方之防曬組成物 | |
| CN103027851A (zh) | 局部用防晒组合物 | |
| BR102012024484A2 (pt) | composição de filtro solar tópica | |
| KR100744946B1 (ko) | 저농도의 친유성 계면활성제 및 셀룰로오스 알킬 에테르를유효성분으로 함유하는 유중수형 화장료 조성물 | |
| JP4182186B2 (ja) | 水溶性高分子抗菌剤 | |
| TW202245731A (zh) | 水中油型乳化化妝料 | |
| JP2023166031A (ja) | 皮膚外用剤 | |
| FR3127691A1 (fr) | Composition de type e/h comprenant un filtre uv organique et une silice hydrophobe sphérique |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: Delaware Patentee after: Ludeqing Co.,Ltd. Address before: California, USA Patentee before: NEUTROGENA Corp. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220428 Address after: new jersey Patentee after: JOHNSON & JOHNSON CONSUMER COMPANIES, Inc. Address before: Delaware Patentee before: Ludeqing Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240322 Address after: new jersey Patentee after: JOHNSON & JOHNSON CONSUMER COMPANIES, Inc. Country or region after: U.S.A. Address before: new jersey Patentee before: JOHNSON & JOHNSON CONSUMER COMPANIES, Inc. Country or region before: U.S.A. |