CN102406115A - Natural functional food for preventing cardiovascular and cerebrovascular diseases - Google Patents
Natural functional food for preventing cardiovascular and cerebrovascular diseases Download PDFInfo
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Abstract
The invention discloses a natural functional food for preventing cardiovascular and cerebrovascular diseases, comprising the following components by weight: 10-30 parts of natto extract, 10-40 parts of crataegus pinnatifida extract, 10-30 parts of allium cepa, 5-30 parts of peach seed extract, and 5-20 parts of chitosan oligosaccharide. The functional food of the invention is formed by scientific rational purification technology through combining modern nutrition foundation according to the theory of ''medicine food homology''. The invention is prepared with the natto extract, the crataegus pinnatifida extract, the allium cepa, the peach seed extract and the chitosan oligosaccharide which are adopted as the raw material, so it has no toxic side effect, effectively dissolves thrombus and fat embolism, reduces the blood viscosity, and reduces the blood lipid.
Description
Technical field
The present invention relates to a kind of functional food, particularly a kind of natural function food of preventing and treating cardiovascular and cerebrovascular disease and preparation method thereof belongs to the technical field of health food.
Background technology
Cardiovascular and cerebrovascular disease is exactly the general designation of cardiovascular and cerebrovascular disease.Cardiovascular and cerebrovascular disease is the elderly's a common disease, also is person in middle and old age's main disease, has become first killer of harm person in middle and old age life.Because the incubation period of cardiovascular and cerebrovascular disease is longer, be not easy at first to find, running up to a certain degree (7-8 begins outbreak).With advancing age, irrational meals and work and rest, few moving, stress is big; Reasons such as blood vessel aging cause high fat of blood, high cholesterol, slow blood flow, the rising of platelet aggregation property; Impurity etc. constantly are deposited on vascular wall, and blood vessel elasticity weakens, and lumen of vessels is narrow.Cause heart and arteries that sclerosis takes place and cause the ischemic of heart and brain or hemorrhage.
The raising of Along with people's quality of life, increasing of high protein, higher fatty acid, high caloric diet chance adds the quickening and the momental minimizing of people's rhythm of life, the fat in the blood consumes to gather owing to burning and causes high fat of blood.In China, people with hyperlipidemia increases with expanding economy, and more and more develops towards the rejuvenation direction, and human beings'health is caused serious threat.Medical science has proved that chance that hyperlipemic patients suffers from a heart complaint is 4 times of normal person.According to epidemiology survey, the illness rate of China's hyperlipidemia is more than 7%, and general trend is northern greater than south, and the city is greater than the rural area.China has hyperlipemia 9,000 ten thousand people approximately at present, wherein has 3,600 ten thousand patient using fat-reducing medicament approximately.Also have 460,000 coronary heart disease patients need control the treatment of blood fat.In addition, the patient who suffers from symptoms such as obesity, fatty liver, diabetes also obtains better controlling because of the higher needs of blood lipid level.Simultaneously,, the demand of lipopenicillinase series products is remained high because people's self health consciousness and consumption and payment ability be greatly improved, thus the lipopenicillinase series products be faced with one huge and be the market that increases day by day.Also just because of this, the source ecological functions food that has the auxiliary antilipemic effect arises at the historic moment.
Summary of the invention
Technical problem to be solved by this invention provides a kind of natural function food of preventing and treating cardiovascular and cerebrovascular disease, and this functional food utilizes natural resources, takes safety, and through reducing blood lipid, thrombus, thereby reach the purpose of preventing and treating cardiovascular and cerebrovascular disease.
The present invention is achieved through following technical scheme.
A kind of natural function food of preventing and treating cardiovascular and cerebrovascular disease is grouped into by following one-tenth: natto extract 10-30 part, haw thorn extract 10-40 part, Bulbus Allii Cepae extract 10-30 part, Semen Persicae extract 5-30 part, chitosan oligosaccharide 5-20 part, and in weight portion.
Above-mentioned a kind of natural function food of preventing and treating cardiovascular and cerebrovascular disease is grouped into by following one-tenth: 20 parts of natto extracts, 30 parts of haw thorn extracts, 20 parts of Bulbus Allii Cepae extracts, 10 parts of Semen Persicae extracts, 10 parts of chitosan oligosaccharides.
Above-mentioned a kind of natural function food of preventing and treating cardiovascular and cerebrovascular disease, wherein, the formulation of said natural function food can be soft capsule, hard shell capsules, tablet and granule.
Beneficial effect of the present invention: functional food of the present invention is the principle according to " integration of drinking and medicinal herbs "; In conjunction with the modern nutriology basis; Purify and develop through scientific and reasonable technology, the present invention is that feedstock production forms with natto extract, haw thorn extract, Bulbus Allii Cepae extract, Semen Persicae extract and chitosan oligosaccharide, has no side effect; Effectively thrombus, fat embolism reduce blood viscosity, reduce blood fat.
Natto is a kind of little environmental health food.Be rich in several physiological active substances such as Bacillus natto, high-quality small protein (peptide), Nattokinase, superoxide dismutase, biological polyoses, isoflavones, saponin, lecithin, pyridinedicarboxylic acid, farnoquinone in the natto.These active materials are comprehensively adjusted four big systems such as people's cardiovascular and cerebrovascular, bone, intestines and stomach, immunity and are improved, and promote physical function and immunity with the effect of uniqueness comprehensively.The main active substances Nattokinase has thrombus, anticoagulation, platelet aggregation-against in the natto, improves effects such as microcirculation; That high-quality small protein (polypeptide) has is anti-ageing, hemangiectasis, the effect that stimulates circulation, and is the essential battalion of brain cell; Hepatocuprein can prevent and eliminate oxygen metabolism and poison, removes active oxygen, free radical, the prevention of arterial sclerosis.Saponin can reduce cholesterol, prevention cholesterol deposition, elimination activity oxygen, free radical, prevention of arterial sclerosis; Isoflavones elimination activity oxygen, prevent cholesterol oxidation, anti-platelet aggregation; Lecithin emulsification, eliminate on the vascular wall cholesterol and with its elimination; Linoleic acid increases useful cholesterol, eliminates bad cholesterol; The natto polysaccharide is anti-ageing, lipopenicillinase, steady blood sugar; Vitamin E prevents the cholesterol oxidation, and oxidized cholesterol neutralizes; Dietary fiber reduces intestinal absorption fat, reduces cholesterol; Vitamin B1 trophic nerve maincenter, nervous system get essential nutrition; Multivitamin and mineral matter participate in regulating important coenzyme and the prothetic group of cardiomotility.
Hawthorn is the dry mature fruit of rosaceous plant large-fruited Chinese hawthorn or hawthorn.The main active ingredient that plant on the mountain is flavone compound and organic acid; Research for many years shows: the flavone compound of haw thorn extract has many-sided pharmacological action; Cardiovascular and cerebrovascular disease there is tangible curative effect; The anti-arrhythmia cordis positive inotropic action of removing oxygen radical reducing blood lipid vasodilator increase coronary flow resisting myocardial ischemia improves hemorheology and the hypotensive diuresis of microcirculation improves Ischemic Stroke such as the cerebral arteriovenous malformation of brain cell metabolism coronary disease and angina pectoris arrhythmia cordis cardiac insufficiency resisting myocardial ischemia, senile dementia, apoplexy sequela.
Onion has another name called onion.Fatty hardly in the Bulbus Allii Cepae extract, but contain compositions such as prostaglandin A, two rare propyl disulfide things and sulphur amino acid.Wherein, prostaglandin A is a kind of stronger vasodilator, can reduce the resistance of human peripheral blood pipe and heart coronary artery, has the blood fat of reduction and prophylaxis of thrombosis effect.Behind the edible one section Bulbus Allii Cepae extract of hyperlipemic patients, cholesterol, triglycerides and lipoprotein in its body all can obviously reduce.Through experiment showed, that Bulbus Allii Cepae extract has significant reducing blood lipid and anticoagulation.
Peach kernel activates blood circulation and disperses blood clots, functions of loosening bowel relieving constipation, and Semen Persicae extract has blood coagulation resisting function, and can suppress coughing centre and cough-relieving.Simultaneously can make blood pressure drops.Semen Persicae extract can reduce acute myocardial infarction, suppresses the rising of CPK, LDH in the serum, reduces the acute myocardial infarction that CAL causes; Semen Persicae extract has the improvement effect to treating myocardial ischemia damage.
Chitosan oligosaccharide is a kind of brand-new product that shitosan is obtained through special biotechnology processing, is the low molecular weight product that good water solubility, function are big, biologically active is high.It has the unexistent higher solubility of shitosan and easily by the function of many uniquenesses such as organism; Chitosan oligosaccharide is described as necessary for human body the 6th vital principle, has and three transfers (immunological regulation, regulate pH value, regulate hormone), three and fall the function that (reducing blood lipid, hypoglycemic, hypotensive), three rows (row's cholesterol, row's heavy metal ion, toxin expelling are plain), three press down (suppress cancer cell, suppress cancer metastasis, inhibition carcinomycin).The main component of health products of the present invention is from the shared natural plants of medicine food, utilization modern extraction technique, the main polysaccharide composition that extracts wherein; Above-mentioned raw materials is formed the comprehensive functional food of nutritional labeling through scientific combination; Can strengthen muscle power, remedy consume, have significant antifatigue effect; Ability enhance immunity function promotes sleep; And this product has thrombus dissolving functions, and bioavilability is high, and the control cardiovascular and cerebrovascular disease is had good effect, has health care and booster action simultaneously.
The specific embodiment
Below in conjunction with specific embodiment the present invention is described further.
Natto extract is the natto fine powder that natto processes.
Semen Persicae extract is the Powdered extract product of yellowish-brown of the seed of japanese rose leaf plant peach, contains amygdalin, emulsin, fatty wet goods composition, for Powdered.
Haw thorn extract is dry mature fruit (the containing nuclear) extract of rosaceous plant hawthorn or large-fruited Chinese hawthorn fructus crataegi cuneatae, for Powdered.
Bulbus Allii Cepae extract is a Bulbus Allii Cepae extract, for Powdered.
Chitosan oligosaccharide is a kind of brand-new product that shitosan is obtained through special biotechnology processing, is the low molecular weight product that good water solubility, function are big, biologically active is high.
The natural function food soft capsule of control cardiovascular and cerebrovascular disease:
Embodiment one
Soft capsule material is added in the adhesive disolving tank, be heated to 70～85 ℃, stir and make dissolving, being evacuated to glue does not have bubble, subsequent use 70 ℃ of insulations.With 10 parts of natto extracts, 40 parts of haw thorn extracts, 30 parts of Bulbus Allii Cepae extracts, 30 parts of Semen Persicae extracts, 20 parts of chitosan oligosaccharides, in weight portion.Above-mentioned raw materials fully is mixed and made into natural function food by proportioning; Add again in the wheat-germ oil of 21g beeswax and 179g; Mixed and vacuumize 30 minutes at 40 ℃, draw film, pelleting then, the capsule after pressing was finalized the design in rotating cage 1.5～3 hours; Be no more than under 30% the condition dry 24 hours in 15～25 ℃ of temperature, relative humidity, health products soft capsule of the present invention.Soft capsule net content of the present invention is the 0.5g/ grain, dose: every day 2 times, each 3.
Embodiment two
Soft capsule material is added in the adhesive disolving tank, be heated to 70～85 ℃, stir and make dissolving, being evacuated to glue does not have bubble, subsequent use 70 ℃ of insulations.With 30 parts of natto extracts, 10 parts of haw thorn extracts, 10 parts of Bulbus Allii Cepae extracts, 5 parts of Semen Persicae extracts, 5 parts of chitosan oligosaccharides, in weight portion.Above-mentioned raw materials fully is mixed and made into natural function food by proportioning; Add again in the wheat-germ oil of 21g beeswax and 179g; Mixed and vacuumize 30 minutes at 40 ℃, draw film, pelleting then, the capsule after pressing was finalized the design in rotating cage 1.5～3 hours; Be no more than under 30% the condition dry 24 hours in 15～25 ℃ of temperature, relative humidity, health products soft capsule of the present invention.Soft capsule net content of the present invention is the 0.5g/ grain, dose: every day 2 times, each 3.
Embodiment three
Soft capsule material is added in the adhesive disolving tank, be heated to 70～85 ℃, stir and make dissolving, being evacuated to glue does not have bubble, subsequent use 70 ℃ of insulations.With 20 parts of natto extracts, 30 parts of haw thorn extracts, 20 parts of Bulbus Allii Cepae extracts, 10 parts of Semen Persicae extracts, 10 parts of chitosan oligosaccharides.Above-mentioned raw materials fully is mixed and made into natural function food by proportioning; Add again in the wheat-germ oil of 21g beeswax and 179g; Mixed and vacuumize 30 minutes at 40 ℃, draw film, pelleting then, the capsule after pressing was finalized the design in rotating cage 1.5～3 hours; Be no more than under 30% the condition dry 24 hours in 15～25 ℃ of temperature, relative humidity, health products soft capsule of the present invention.Soft capsule net content of the present invention is the 0.5g/ grain, dose: every day 2 times, each 3.
The natural function food hard shell capsules of control cardiovascular and cerebrovascular disease:
Embodiment four
With 10 parts of natto extracts, 40 parts of haw thorn extracts, 30 parts of Bulbus Allii Cepae extracts, 30 parts of Semen Persicae extracts, 20 parts of chitosan oligosaccharides, in weight portion.Be mixed and made into natural function food by proportioning, add 10～20g superfine silica gel powder and 5～15g pregelatinized starch, mix; Wherein, superfine silica gel powder, pregelatinized starch account for the 5-10% of total inventory, are that 90% edible ethanol is granulated with mass percent concentration again; Dry; Sieve, incapsulate, get health products hard shell capsules of the present invention.Hard shell capsules net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
Embodiment five
With 30 parts of natto extracts, 10 parts of haw thorn extracts, 10 parts of Bulbus Allii Cepae extracts, 5 parts of Semen Persicae extracts, 5 parts of chitosan oligosaccharides, in weight portion.Be mixed and made into natural function food by proportioning, add 10～20g superfine silica gel powder and 5～15g pregelatinized starch, mix; Wherein, superfine silica gel powder, pregelatinized starch account for the 5-10% of total inventory, are that 90% edible ethanol is granulated with mass percent concentration again; Dry; Sieve, incapsulate, get health products hard shell capsules of the present invention.Hard shell capsules net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
Embodiment six
10 parts of 20 parts of natto extracts, 30 parts of haw thorn extracts, 20 parts of Bulbus Allii Cepae extracts, 10 parts of Semen Persicae extracts, chitosan oligosaccharide are mixed and made into natural function food by proportioning, add 10～20g superfine silica gel powder and 5～15g pregelatinized starch, mix; Wherein, superfine silica gel powder, pregelatinized starch account for the 5-10% of total inventory, are that 90% edible ethanol is granulated with mass percent concentration again; Dry; Sieve, incapsulate, get health products hard shell capsules of the present invention.Hard shell capsules net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
The natural function food tablet of control cardiovascular and cerebrovascular disease:
Embodiment seven
With 10 parts of natto extracts, 40 parts of haw thorn extracts, 30 parts of Bulbus Allii Cepae extracts, 30 parts of Semen Persicae extracts, 20 parts of chitosan oligosaccharides, in weight portion.Above-mentioned raw materials is mixed and made into natural function food by proportioning, in the natural function food of above-mentioned processing, adds 5～15g superfine silica gel powder, 5～15g pregelatinized starch and 5～10g calcium monohydrogen phosphate again, mix; Wherein, superfine silica gel powder, pregelatinized starch and calcium monohydrogen phosphate account for the 5-10% of total inventory, granulate with 90% edible ethanol solution again; Drying is sieved, compressing tablet; Dressing gets troche of health products of the present invention.Tablet net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
Embodiment eight
With 30 parts of natto extracts, 10 parts of haw thorn extracts, 10 parts of Bulbus Allii Cepae extracts, 5 parts of Semen Persicae extracts, 5 parts of chitosan oligosaccharides, in weight portion.Above-mentioned raw materials is mixed and made into natural function food by proportioning, in the natural function food of above-mentioned processing, adds 5～15g superfine silica gel powder, 5～15g pregelatinized starch and 5～10g calcium monohydrogen phosphate again, mix; The ratio of natural function food and superfine silica gel powder, pregelatinized starch and calcium monohydrogen phosphate is: what? Be that 90% edible ethanol solution is granulated with mass percent concentration again; Drying is sieved, compressing tablet; Dressing gets troche of health products of the present invention.Tablet net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
Embodiment nine
10 parts of 20 parts of natto extracts, 30 parts of haw thorn extracts, 20 parts of Bulbus Allii Cepae extracts, 10 parts of Semen Persicae extracts, chitosan oligosaccharide are mixed and made into natural function food by proportioning, above-mentioned raw materials is mixed and made into natural function food by proportioning, in the natural function food of above-mentioned processing, add 5～15g superfine silica gel powder, 5～15g pregelatinized starch and 5～10g calcium monohydrogen phosphate again; Mix, wherein, superfine silica gel powder, pregelatinized starch and calcium monohydrogen phosphate account for the 5-10% of total inventory; Be that 90% edible ethanol solution is granulated with mass percent concentration again; Drying is sieved, compressing tablet; Dressing gets troche of health products of the present invention.Tablet net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
The natural function food granule agent of control cardiovascular and cerebrovascular disease:
Embodiment ten
With 10 parts of natto extracts, 40 parts of haw thorn extracts, 30 parts of Bulbus Allii Cepae extracts, 30 parts of Semen Persicae extracts, 20 parts of chitosan oligosaccharides, in weight portion.Be mixed and made into natural function food by proportioning, in the natural function food of above-mentioned processing, add 200～300g granulated sugar powder, 250～400g starch, 300～400g dextrin and 5～15g stevioside again, wherein; Granulated sugar powder, starch, dextrin and stevioside account for the 5-10% of the total amount that feeds intake; Using mass percent concentration again is that 85% edible ethanol is granulated, drying, whole grain; Pack gets health products granule of the present invention.Granule net content of the present invention is the 5g/ bag, dose: every day 2 times, each 1 bag.
Embodiment 11
With 30 parts of natto extracts, 10 parts of haw thorn extracts, 10 parts of Bulbus Allii Cepae extracts, 5 parts of Semen Persicae extracts, 5 parts of chitosan oligosaccharides, in weight portion.Be mixed and made into natural function food by proportioning, in the natural function food of above-mentioned processing, add 200～300g granulated sugar powder, 250～400g starch, 300～400g dextrin and 5～15g stevioside again, wherein; Granulated sugar powder, starch, dextrin and stevioside account for the 5-10% of the total amount that feeds intake, and using mass percent concentration again is that 85% edible ethanol is granulated; Dry; Whole grain, pack gets health products granule of the present invention.Granule net content of the present invention is the 5g/ bag, dose: every day 2 times, each 1 bag.
Embodiment 12
Just 20 parts of natto extracts, 30 parts of haw thorn extracts, 20 parts of Bulbus Allii Cepae extracts, 10 parts of Semen Persicae extracts, 10 parts of chitosan oligosaccharides are in weight portion.Be mixed and made into natural function food by proportioning, in the natural function food of above-mentioned processing, add 200～300g granulated sugar powder, 250～400g starch, 300～400g dextrin and 5～15g stevioside again, wherein; Granulated sugar powder, starch, dextrin and stevioside account for the 5-10% of the total amount that feeds intake, and using mass percent concentration again is that 85% edible ethanol is granulated; Dry; Whole grain, pack gets health products granule of the present invention.Granule net content of the present invention is the 5g/ bag, dose: every day 2 times, each 1 bag.
The test-meal result: with the soft capsule is the test-meal sample
The test-meal conclusion:
Adopt counter point between own control and group, the volunteer who selects to meet experimental condition takes and is tried thing after 45 days, and the result shows: compare before taking CHOL after the natural function food test group of the present invention test-meal, TG and test-meal.Difference has conspicuousness (P＜0.05), and reduces by 10.18%, 22.59% before CHOL, TG and the test-meal more respectively after the test-meal; Compare before test-meal group CHOL, TG and the test-meal and after the control group test-meal after the test-meal, difference has conspicuousness (P＜0.05); Test-meal group HDL-C and control group comparing difference do not have conspicuousness (p＞0.05) after the test-meal.Do not see obvious adverse reaction during the test-meal.According to " health food check and assessment technique standard " (version in 2003) evaluation criterion, the prompting given the test agent has the auxiliary lipid-lowering function effect, can prevent and treat cardiovascular and cerebrovascular disease.(seeing following table for details)
Body weight, blood pressure, heart rate, routine urinalysis, stool routine examination and routine blood test situation of change
before and after the table 1 test-meal test
Blood biochemistry index situation of change
before and after the table 2 test-meal test
Forward and backward test-meal group of test-meal sample and control group total serum protein (TP), albumin (ALB), glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminease (AST), creatinine (Cr), blood sugar (GLU), uric acid (UA), urea nitrogen (BUN) all no abnormality seen change.
Effect is observed and is seen table 3,4,5.
Blood sampling twice in half a year is respectively test-meal preceding 1 and the preceding 2 blood fat data of test-meal, with the date near the test-meal of taking given the test agent before 2 blood lipid levels divide into groups and statistical disposition.Control group and test-meal group change of serum C HOL, TG level compare before the test-meal, and difference does not have conspicuousness (P＞0.05).Point out between two groups and have comparativity.Compare before CHOL, TG and the test-meal and after the control group test-meal after the test-meal of test-meal group, difference all has conspicuousness (P＜0.05).The HDL-C level is not seen obviously this table (P＞0.05) before and after the test-meal.
Change of serum C HOL, TG, HDL-C level
before the table 3 test-meal test
Change of serum C HOL, TG, HDL-C level
before and after the table 4 test-meal test
Change of serum C HOL, TG, HDL-C situation of change before and after table 5 test-meal
Claims (3)
1. natural function food of preventing and treating cardiovascular and cerebrovascular disease; It is characterized in that; Be grouped into by following one-tenth: natto extract 10-30 part, haw thorn extract 10-40 part, Bulbus Allii Cepae extract 10-30 part, Semen Persicae extract 5-30 part, chitosan oligosaccharide 5-20 part, in weight portion.
2. the natural function food of control cardiovascular and cerebrovascular disease as claimed in claim 1 is characterized in that, is grouped into by following one-tenth: 20 parts of natto extracts, 30 parts of haw thorn extracts, 20 parts of Bulbus Allii Cepae extracts, 10 parts of Semen Persicae extracts, 10 parts of chitosan oligosaccharides.
3. as claimed in claim the natural function food of control cardiovascular and cerebrovascular disease is characterized in that the formulation of said natural function food can be soft capsule, hard shell capsules, tablet and granule.
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| CN107184966A (en) * | 2017-06-19 | 2017-09-22 | 青岛金海宝生物科技发展有限公司 | A kind of pharmaceutical composition for preventing and treating diabetes and its complication |
| CN109259092A (en) * | 2017-07-17 | 2019-01-25 | 山西怡康德盛生物科技有限公司 | A kind of food and preparation method thereof |
| CN114588194A (en) * | 2022-03-01 | 2022-06-07 | 沈阳药大生物科技有限公司 | Biological component composition for improving blood viscosity and blood vessel embolism |
| CN114984196A (en) * | 2022-06-30 | 2022-09-02 | 北京悦意时光生物科技有限公司 | Natural plant composition for preventing and treating arteriosclerosis, preparation method and application |
| CN114984196B (en) * | 2022-06-30 | 2023-01-06 | 北京悦意时光生物科技有限公司 | Natural plant composition for preventing and treating arteriosclerosis, preparation method and application |
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