Summary of the invention
Technical problem to be solved by this invention provides a kind of natural function food of preventing and treating cardiovascular and cerebrovascular disease, and this functional food utilizes natural resources, takes safety, and by reducing blood lipid, thrombus, thereby reach the purpose of preventing and treating cardiovascular and cerebrovascular disease.
The present invention is achieved by the following technical programs.
A kind of natural function food of preventing and treating cardiovascular and cerebrovascular disease is grouped into by following one-tenth: natto extract 10-30 part, haw thorn extract 10-40 part, Bulbus Allii Cepae extract 10-30 part, Semen Persicae extract 5-30 part, chitosan oligosaccharide 5-20 part, and in weight portion.
Above-mentioned a kind of natural function food of preventing and treating cardiovascular and cerebrovascular disease is grouped into by following one-tenth: 20 parts of natto extracts, 30 parts of haw thorn extracts, 20 parts of Bulbus Allii Cepae extracts, 10 parts of Semen Persicae extracts, 10 parts of chitosan oligosaccharides.
Above-mentioned a kind of natural function food of preventing and treating cardiovascular and cerebrovascular disease, wherein, the formulation of described natural function food can be soft capsule, hard shell capsules, tablet and granule.
Beneficial effect of the present invention: functional food of the present invention is the principle according to " integration of drinking and medicinal herbs ", in conjunction with the modern nutriology basis, purify and develop through scientific and reasonable technology, the present invention is that feedstock production forms with natto extract, haw thorn extract, Bulbus Allii Cepae extract, Semen Persicae extract and chitosan oligosaccharide, have no side effect, effectively thrombus, fat embolism reduce blood viscosity, reduce blood fat.
Natto is a kind of little environmental health food.Be rich in several physiological active substances such as Bacillus natto, high-quality small protein (peptide), Nattokinase, superoxide dismutase, biological polyoses, isoflavones, saponin, lecithin, pyridinedicarboxylic acid, farnoquinone in the natto.These active materials are comprehensively adjusted four big systems such as people's cardiovascular and cerebrovascular, bone, intestines and stomach, immunity and are improved, and promote physical function and immunity with the effect of uniqueness comprehensively.The main active substances Nattokinase has thrombus, anticoagulation, platelet aggregation-against in the natto, improves effects such as microcirculation; That high-quality small protein (polypeptide) has is anti-ageing, hemangiectasis, the effect that stimulates circulation, and is the essential battalion of brain cell; Hepatocuprein can prevent and eliminate oxygen metabolism and poison, removes active oxygen, free radical, the prevention of arterial sclerosis.Saponin can reduce cholesterol, prevention cholesterol deposition, elimination activity oxygen, free radical, prevention of arterial sclerosis; Isoflavones elimination activity oxygen, prevent cholesterol oxidation, anti-platelet aggregation; Lecithin emulsification, eliminate on the vascular wall cholesterol and with its elimination; Linoleic acid increases useful cholesterol, eliminates bad cholesterol; The natto polysaccharide is anti-ageing, lipopenicillinase, steady blood sugar; Vitamin E prevents the cholesterol oxidation, and oxidized cholesterol neutralizes; Dietary fiber reduces intestinal absorption fat, reduces cholesterol; Vitamin B1 trophic nerve maincenter, nervous system get essential nutrition; Multivitamin and mineral matter participate in regulating important coenzyme and the prothetic group of cardiomotility.
Hawthorn is the dry mature fruit of rosaceous plant large-fruited Chinese hawthorn or hawthorn.The main active ingredient that plant on the mountain is flavone compound and organic acid, studies show that for many years: the flavone compound of haw thorn extract has many-sided pharmacological action, cardiovascular and cerebrovascular disease there is tangible curative effect, removing oxygen radical reducing blood lipid vasodilator increases the anti-arrhythmia cordis positive inotropic action of coronary flow and resists myocardial ischemia and improve hemorheology and the hypotensive diuresis of microcirculation and improve the brain cell metabolism coronary disease and angina pectoris arrhythmia cordis cardiac insufficiency Ischemic Stroke such as cerebral arteriovenous malformation, senile dementia that resist myocardial ischemia, apoplexy sequela.
Onion has another name called onion.Fatty hardly in the Bulbus Allii Cepae extract, but contain compositions such as prostaglandin A, two rare propyl disulfide things and sulphur amino acid.Wherein, prostaglandin A is a kind of stronger vasodilator, can reduce the resistance of human peripheral blood pipe and heart coronary artery, has the blood fat of reduction and the thrombotic effect of prevention.Behind the edible one section Bulbus Allii Cepae extract of hyperlipemic patients, cholesterol, triglycerides and lipoprotein in its body all can obviously reduce.The experiment proved that Bulbus Allii Cepae extract has significant reducing blood lipid and anticoagulation.
Peach kernel activates blood circulation and disperses blood clots, functions of loosening bowel relieving constipation, and Semen Persicae extract has blood coagulation resisting function, and can suppress coughing centre and cough-relieving.Simultaneously can make blood pressure drops.Semen Persicae extract can reduce acute myocardial infarction, suppresses the rising of CPK, LDH in the serum, reduces the acute myocardial infarction that CAL causes; Semen Persicae extract has the improvement effect to treating myocardial ischemia damage.
Chitosan oligosaccharide is a kind of brand-new product that shitosan is obtained through special biotechnology processing, is the low molecular weight product that good water solubility, function are big, biologically active is high.It has the unexistent higher solubility of shitosan and easily by the function of many uniquenesses such as organism absorption, chitosan oligosaccharide is described as necessary for human body the 6th vital principle, has and three transfers (immunological regulation, regulate pH value, regulate hormone), three and fall the function that (reducing blood lipid, hypoglycemic, hypotensive), three rows (row's cholesterol, row's heavy metal ion, toxin expelling element), three press down (suppress cancer cell, suppress cancer metastasis, inhibition carcinomycin).The natural plants that the main component of health products of the present invention shares from the medicine food, use modern extraction technique, the main polysaccharide composition that extracts wherein, above-mentioned raw materials is combined to form the comprehensive functional food of nutritional labeling through science, can strengthen muscle power, remedy consume, have significant antifatigue effect, can strengthen immunity function, promote sleep; And this product has thrombus dissolving functions, and the bioavilability height has good effect to the control cardiovascular and cerebrovascular disease, has health care and booster action simultaneously.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment.
Natto extract is the natto fine powder that natto processes.
Semen Persicae extract is the Powdered extract product of yellowish-brown of the seed of japanese rose leaf plant peach, contains amygdalin, emulsin, fatty wet goods composition, for Powdered.
Haw thorn extract is dry mature fruit (the containing nuclear) extract of rosaceous plant hawthorn or large-fruited Chinese hawthorn fructus crataegi cuneatae, for Powdered.
Bulbus Allii Cepae extract is Bulbus Allii Cepae extract, for Powdered.
Chitosan oligosaccharide is a kind of brand-new product that shitosan is obtained through special biotechnology processing, is the low molecular weight product that good water solubility, function are big, biologically active is high.
The natural function food soft capsule of control cardiovascular and cerebrovascular disease:
Embodiment one
Soft capsule material is added in the adhesive disolving tank, be heated to 70~85 ℃, stir and make dissolving, being evacuated to glue does not have bubble, standby 70 ℃ of insulations.With 10 parts of natto extracts, 40 parts of haw thorn extracts, 30 parts of Bulbus Allii Cepae extracts, 30 parts of Semen Persicae extracts, 20 parts of chitosan oligosaccharides, in weight portion.Above-mentioned raw materials fully is mixed and made into natural function food by proportioning, add again in the wheat-germ oil of 21g beeswax and 179g, mixed and vacuumize 30 minutes at 40 ℃, draw film, pelleting then, capsule after pressing was finalized the design in rotating cage 1.5~3 hours, be no more than under 30% the condition dry 24 hours in 15~25 ℃ of temperature, relative humidity, get health products soft capsule of the present invention.Soft capsule net content of the present invention is the 0.5g/ grain, dose: every day 2 times, each 3.
Embodiment two
Soft capsule material is added in the adhesive disolving tank, be heated to 70~85 ℃, stir and make dissolving, being evacuated to glue does not have bubble, standby 70 ℃ of insulations.With 30 parts of natto extracts, 10 parts of haw thorn extracts, 10 parts of Bulbus Allii Cepae extracts, 5 parts of Semen Persicae extracts, 5 parts of chitosan oligosaccharides, in weight portion.Above-mentioned raw materials fully is mixed and made into natural function food by proportioning, add again in the wheat-germ oil of 21g beeswax and 179g, mixed and vacuumize 30 minutes at 40 ℃, draw film, pelleting then, capsule after pressing was finalized the design in rotating cage 1.5~3 hours, be no more than under 30% the condition dry 24 hours in 15~25 ℃ of temperature, relative humidity, get health products soft capsule of the present invention.Soft capsule net content of the present invention is the 0.5g/ grain, dose: every day 2 times, each 3.
Embodiment three
Soft capsule material is added in the adhesive disolving tank, be heated to 70~85 ℃, stir and make dissolving, being evacuated to glue does not have bubble, standby 70 ℃ of insulations.With 20 parts of natto extracts, 30 parts of haw thorn extracts, 20 parts of Bulbus Allii Cepae extracts, 10 parts of Semen Persicae extracts, 10 parts of chitosan oligosaccharides.Above-mentioned raw materials fully is mixed and made into natural function food by proportioning, add again in the wheat-germ oil of 21g beeswax and 179g, mixed and vacuumize 30 minutes at 40 ℃, draw film, pelleting then, capsule after pressing was finalized the design in rotating cage 1.5~3 hours, be no more than under 30% the condition dry 24 hours in 15~25 ℃ of temperature, relative humidity, get health products soft capsule of the present invention.Soft capsule net content of the present invention is the 0.5g/ grain, dose: every day 2 times, each 3.
The natural function food hard shell capsules of control cardiovascular and cerebrovascular disease:
Embodiment four
With 10 parts of natto extracts, 40 parts of haw thorn extracts, 30 parts of Bulbus Allii Cepae extracts, 30 parts of Semen Persicae extracts, 20 parts of chitosan oligosaccharides, in weight portion.Be mixed and made into natural function food by proportioning, add 10~20g superfine silica gel powder and 5~15g pregelatinized starch, mix, wherein, superfine silica gel powder, pregelatinized starch account for the 5-10% of total inventory, are that 90% edible ethanol is granulated with mass percent concentration again, dry, sieve, incapsulate, get health products hard shell capsules of the present invention.Hard shell capsules net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
Embodiment five
With 30 parts of natto extracts, 10 parts of haw thorn extracts, 10 parts of Bulbus Allii Cepae extracts, 5 parts of Semen Persicae extracts, 5 parts of chitosan oligosaccharides, in weight portion.Be mixed and made into natural function food by proportioning, add 10~20g superfine silica gel powder and 5~15g pregelatinized starch, mix, wherein, superfine silica gel powder, pregelatinized starch account for the 5-10% of total inventory, are that 90% edible ethanol is granulated with mass percent concentration again, dry, sieve, incapsulate, get health products hard shell capsules of the present invention.Hard shell capsules net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
Embodiment six
10 parts of 20 parts of natto extracts, 30 parts of haw thorn extracts, 20 parts of Bulbus Allii Cepae extracts, 10 parts of Semen Persicae extracts, chitosan oligosaccharide are mixed and made into natural function food by proportioning, add 10~20g superfine silica gel powder and 5~15g pregelatinized starch, mix, wherein, superfine silica gel powder, pregelatinized starch account for the 5-10% of total inventory, are that 90% edible ethanol is granulated with mass percent concentration again, dry, sieve, incapsulate, get health products hard shell capsules of the present invention.Hard shell capsules net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
The natural function food tablet of control cardiovascular and cerebrovascular disease:
Embodiment seven
With 10 parts of natto extracts, 40 parts of haw thorn extracts, 30 parts of Bulbus Allii Cepae extracts, 30 parts of Semen Persicae extracts, 20 parts of chitosan oligosaccharides, in weight portion.Above-mentioned raw materials is mixed and made into natural function food by proportioning, in the natural function food of above-mentioned processing, add 5~15g superfine silica gel powder, 5~15g pregelatinized starch and 5~10g calcium monohydrogen phosphate again, mix, wherein, superfine silica gel powder, pregelatinized starch and calcium monohydrogen phosphate account for the 5-10% of total inventory, granulate with 90% edible ethanol solution again, drying is sieved, compressing tablet, dressing gets troche of health products of the present invention.Tablet net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
Embodiment eight
With 30 parts of natto extracts, 10 parts of haw thorn extracts, 10 parts of Bulbus Allii Cepae extracts, 5 parts of Semen Persicae extracts, 5 parts of chitosan oligosaccharides, in weight portion.Above-mentioned raw materials is mixed and made into natural function food by proportioning, in the natural function food of above-mentioned processing, add 5~15g superfine silica gel powder, 5~15g pregelatinized starch and 5~10g calcium monohydrogen phosphate again, mix, the ratio of natural function food and superfine silica gel powder, pregelatinized starch and calcium monohydrogen phosphate is: what? be that 90% edible ethanol solution is granulated with mass percent concentration again, drying is sieved, compressing tablet, dressing gets troche of health products of the present invention.Tablet net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
Embodiment nine
With 20 parts of natto extracts, 30 parts of haw thorn extracts, 20 parts of Bulbus Allii Cepae extracts, 10 parts of Semen Persicae extracts, 10 parts of chitosan oligosaccharides are mixed and made into natural function food by proportioning, above-mentioned raw materials is mixed and made into natural function food by proportioning, in the natural function food of above-mentioned processing, add 5~15g superfine silica gel powder again, 5~15g pregelatinized starch and 5~10g calcium monohydrogen phosphate, mix, wherein, superfine silica gel powder, pregelatinized starch and calcium monohydrogen phosphate account for the 5-10% of total inventory, be that 90% edible ethanol solution is granulated with mass percent concentration again, dry, sieve, compressing tablet, dressing gets troche of health products of the present invention.Tablet net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
The natural function food granule agent of control cardiovascular and cerebrovascular disease:
Embodiment ten
With 10 parts of natto extracts, 40 parts of haw thorn extracts, 30 parts of Bulbus Allii Cepae extracts, 30 parts of Semen Persicae extracts, 20 parts of chitosan oligosaccharides, in weight portion.Be mixed and made into natural function food by proportioning, in the natural function food of above-mentioned processing, add 200~300g granulated sugar powder, 250~400g starch, 300~400g dextrin and 5~15g stevioside again, wherein, granulated sugar powder, starch, dextrin and stevioside account for the 5-10% of the total amount that feeds intake, be that 85% edible ethanol is granulated with mass percent concentration again, drying, whole grain, pack gets health products granule of the present invention.Granule net content of the present invention is the 5g/ bag, dose: every day 2 times, each 1 bag.
Embodiment 11
With 30 parts of natto extracts, 10 parts of haw thorn extracts, 10 parts of Bulbus Allii Cepae extracts, 5 parts of Semen Persicae extracts, 5 parts of chitosan oligosaccharides, in weight portion.Be mixed and made into natural function food by proportioning, in the natural function food of above-mentioned processing, add 200~300g granulated sugar powder, 250~400g starch, 300~400g dextrin and 5~15g stevioside again, wherein, granulated sugar powder, starch, dextrin and stevioside account for the 5-10% of the total amount that feeds intake, and are 85% edible ethanol granulation again with mass percent concentration, dry, whole grain, pack gets health products granule of the present invention.Granule net content of the present invention is the 5g/ bag, dose: every day 2 times, each 1 bag.
Embodiment 12
Just 20 parts of natto extracts, 30 parts of haw thorn extracts, 20 parts of Bulbus Allii Cepae extracts, 10 parts of Semen Persicae extracts, 10 parts of chitosan oligosaccharides are in weight portion.Be mixed and made into natural function food by proportioning, in the natural function food of above-mentioned processing, add 200~300g granulated sugar powder, 250~400g starch, 300~400g dextrin and 5~15g stevioside again, wherein, granulated sugar powder, starch, dextrin and stevioside account for the 5-10% of the total amount that feeds intake, and are 85% edible ethanol granulation again with mass percent concentration, dry, whole grain, pack gets health products granule of the present invention.Granule net content of the present invention is the 5g/ bag, dose: every day 2 times, each 1 bag.
Test-meal result: be the test-meal sample with the soft capsule
The test-meal conclusion:
Adopt counter point between own control and group, the volunteer who selects to meet experimental condition takes and is tried thing after 45 days, and the result shows: take after the natural function food test group of the present invention test-meal and compare before CHOL, the TG and test-meal.Difference has conspicuousness (P<0.05), and reduces by 10.18%, 22.59% more respectively before CHOL, TG and the test-meal after the test-meal; Compare before test-meal group CHOL, TG and the test-meal and after the control group test-meal after the test-meal, difference has conspicuousness (P<0.05); Test-meal group HDL-C and control group comparing difference do not have conspicuousness (p>0.05) after the test-meal.Do not see obvious adverse reaction during the test-meal.According to " health food check and assessment technique standard " (version in 2003) evaluation criterion, the prompting given the test agent has the auxiliary lipid-lowering function effect, can prevent and treat cardiovascular and cerebrovascular disease.(seeing following table for details)
Body weight, blood pressure, heart rate, routine urinalysis, stool routine examination and routine blood test situation of change before and after the table 1 test-meal test
Blood biochemistry index situation of change before and after the table 2 test-meal test
The forward and backward test-meal group of test-meal sample and control group total serum protein (TP), albumin (ALB), glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminease (AST), creatinine (Cr), blood sugar (GLU), uric acid (UA), urea nitrogen (BUN) there is no ANOMALOUS VARIATIONS.
Effect is observed and is seen Table 3,4,5.
Blood sampling twice is respectively the preceding 2 blood fat data of test-meal preceding 1 and test-meal in half a year, divides into groups and statistical disposition with 2 blood lipid levels before the close test-meal of taking given the test agent of date.Control group and test-meal group change of serum C HOL, TG level compare before the test-meal, and difference does not have conspicuousness (P>0.05).Point out between two groups and have comparativity.Compare before CHOL, TG and the test-meal and after the control group test-meal after the test-meal of test-meal group, difference all has conspicuousness (P<0.05).The HDL-C level is not seen obviously this table (P>0.05) before and after the test-meal.
Change of serum C HOL, TG, HDL-C level before the table 3 test-meal test
Change of serum C HOL, TG, HDL-C level before and after the table 4 test-meal test
Change of serum C HOL, TG, HDL-C situation of change before and after table 5 test-meal