CN102405236A - 改进的抗-tnfr1多肽，抗体可变结构域和拮抗剂 - Google Patents

改进的抗-tnfr1多肽，抗体可变结构域和拮抗剂 Download PDF

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CN102405236A
CN102405236A CN2010800173301A CN201080017330A CN102405236A CN 102405236 A CN102405236 A CN 102405236A CN 2010800173301 A CN2010800173301 A CN 2010800173301A CN 201080017330 A CN201080017330 A CN 201080017330A CN 102405236 A CN102405236 A CN 102405236A
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dom1h
seq
tnfr1
single variable
variable domains
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S.杜菲尔德
C.埃内弗
H.刘
O.肖恩
A.塞普
A.A.斯图普
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Glaxo Group Ltd
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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CN2010800173301A 2009-02-19 2010-02-17 改进的抗-tnfr1多肽，抗体可变结构域和拮抗剂 Pending CN102405236A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15374609P 2009-02-19 2009-02-19
US61/153746 2009-02-19
US24119809P 2009-09-10 2009-09-10
US61/241198 2009-09-10
PCT/EP2010/052005 WO2010094720A2 (en) 2009-02-19 2010-02-17 Improved anti-tnfr1 polypeptides, antibody variable domains & antagonists

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US (1) US20110301335A1 (cg-RX-API-DMAC10.html)
EP (1) EP2398827A2 (cg-RX-API-DMAC10.html)
JP (2) JP2012517818A (cg-RX-API-DMAC10.html)
KR (1) KR20110119806A (cg-RX-API-DMAC10.html)
CN (1) CN102405236A (cg-RX-API-DMAC10.html)
AU (1) AU2010215479B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI1008014A2 (cg-RX-API-DMAC10.html)
CA (1) CA2750477A1 (cg-RX-API-DMAC10.html)
EA (1) EA022925B1 (cg-RX-API-DMAC10.html)
IL (1) IL214648A0 (cg-RX-API-DMAC10.html)
MX (1) MX2011008799A (cg-RX-API-DMAC10.html)
SG (1) SG173173A1 (cg-RX-API-DMAC10.html)
WO (1) WO2010094720A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA201105627B (cg-RX-API-DMAC10.html)

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CN107043413A (zh) * 2016-02-05 2017-08-15 华中农业大学 一种肺结核相关的尿液生物标志蛋白及其应用
CN108473563A (zh) * 2015-11-12 2018-08-31 埃博灵克斯股份有限公司 改进的tnf结合剂
CN113711038A (zh) * 2019-01-31 2021-11-26 积水医疗株式会社 用于生物样品中游离aim的免疫分析方法及用于检测对象中nash的方法
WO2025021184A1 (zh) * 2023-07-27 2025-01-30 上海复宏汉霖生物医药有限公司 编码尿酸氧化酶的多核苷酸及其相关组合物和方法

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108473563A (zh) * 2015-11-12 2018-08-31 埃博灵克斯股份有限公司 改进的tnf结合剂
CN108473563B (zh) * 2015-11-12 2022-06-14 埃博灵克斯股份有限公司 改进的tnf结合剂
CN107043413A (zh) * 2016-02-05 2017-08-15 华中农业大学 一种肺结核相关的尿液生物标志蛋白及其应用
CN113711038A (zh) * 2019-01-31 2021-11-26 积水医疗株式会社 用于生物样品中游离aim的免疫分析方法及用于检测对象中nash的方法
WO2025021184A1 (zh) * 2023-07-27 2025-01-30 上海复宏汉霖生物医药有限公司 编码尿酸氧化酶的多核苷酸及其相关组合物和方法

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KR20110119806A (ko) 2011-11-02
IL214648A0 (en) 2011-09-27
AU2010215479B2 (en) 2015-01-22
WO2010094720A3 (en) 2011-01-13
CA2750477A1 (en) 2010-08-26
EA022925B1 (ru) 2016-03-31
SG173173A1 (en) 2011-08-29
EA201190116A1 (ru) 2012-06-29
MX2011008799A (es) 2011-09-27
EP2398827A2 (en) 2011-12-28
JP2016007218A (ja) 2016-01-18
WO2010094720A2 (en) 2010-08-26
ZA201105627B (en) 2013-01-30
BRPI1008014A2 (pt) 2016-10-04
US20110301335A1 (en) 2011-12-08
AU2010215479A1 (en) 2011-08-25

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