CN102405229A - 作为甲状旁腺激素(pth)受体激动剂的短链肽 - Google Patents

作为甲状旁腺激素(pth)受体激动剂的短链肽 Download PDF

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Publication number
CN102405229A
CN102405229A CN2010800175792A CN201080017579A CN102405229A CN 102405229 A CN102405229 A CN 102405229A CN 2010800175792 A CN2010800175792 A CN 2010800175792A CN 201080017579 A CN201080017579 A CN 201080017579A CN 102405229 A CN102405229 A CN 102405229A
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CN
China
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aib
phe
nle
eiq
har
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Pending
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CN2010800175792A
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English (en)
Chinese (zh)
Inventor
拉杰什·巴赫卡尔
穆库尔·R·贾因
潘卡伊·R·帕特尔
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Zydus Lifesciences Ltd
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Cadila Healthcare Ltd
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Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of CN102405229A publication Critical patent/CN102405229A/zh
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/635Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2010800175792A 2009-04-24 2010-04-26 作为甲状旁腺激素(pth)受体激动剂的短链肽 Pending CN102405229A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN1095MU2009 2009-04-24
IN1095/MUM/2009 2009-04-24
IN225/MUM/2010 2010-01-28
IN225MU2010 2010-01-28
PCT/IN2010/000264 WO2010128521A2 (en) 2009-04-24 2010-04-26 Short-chain peptides as parathyroid hormone (pth) receptor agonist

Publications (1)

Publication Number Publication Date
CN102405229A true CN102405229A (zh) 2012-04-04

Family

ID=43050579

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800175792A Pending CN102405229A (zh) 2009-04-24 2010-04-26 作为甲状旁腺激素(pth)受体激动剂的短链肽

Country Status (15)

Country Link
US (1) US8383581B2 (enExample)
EP (1) EP2421893A2 (enExample)
JP (1) JP5744844B2 (enExample)
KR (1) KR101451470B1 (enExample)
CN (1) CN102405229A (enExample)
AU (1) AU2010245642A1 (enExample)
BR (1) BRPI1008103A2 (enExample)
CA (1) CA2757874C (enExample)
EA (1) EA022212B1 (enExample)
IL (1) IL215625A (enExample)
MX (1) MX2011010968A (enExample)
NZ (1) NZ595437A (enExample)
SG (1) SG174532A1 (enExample)
WO (1) WO2010128521A2 (enExample)
ZA (1) ZA201107078B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3928487A (en) * 1974-11-27 1975-12-23 Standard Oil Co Alkylation process utilizing hydrofluoric acid with a minor amount of fluorosulfuric acid
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
EP2658858A4 (en) 2010-12-30 2014-06-25 Enanta Pharm Inc MACROCYCLIC INHIBITORS OF HEPATITIS C SERINE PROTEASE PHENANTHRIDINE
MX2013007677A (es) 2010-12-30 2013-07-30 Abbvie Inc Inhibidores macrociclicos de serina proteasa de hepatitis.
WO2012120532A2 (en) 2011-02-02 2012-09-13 Cadila Healthcare Limited Cyclic short chain peptides
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
WO2024187241A1 (en) * 2023-03-16 2024-09-19 The Florey Institute Of Neuroscience And Mental Health Stapled peptides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003009804A2 (en) * 2001-07-23 2003-02-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
WO2004067021A1 (en) * 2003-01-24 2004-08-12 Gardella Thomas J Conformationally constrained parathyroid hormone (pth) analogs with lactam bridges
US20070111946A1 (en) * 1998-10-22 2007-05-17 Gardella Thomas J Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7734800A (en) * 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
JP4723144B2 (ja) * 1999-09-29 2011-07-13 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモン(pth)のポリペプチド誘導体
AU2002951372A0 (en) 2002-09-13 2002-09-26 St Vincent's Institute Of Medical Research Parathyroid hormone-like polypeptides
EP2201960A1 (en) * 2003-03-19 2010-06-30 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
JP4871128B2 (ja) 2003-07-17 2012-02-08 ザ ジェネラル ホスピタル コーポレイション 高次構造的に制約された副甲状腺ホルモン(pth)アナログ
US20070123548A1 (en) 2004-02-11 2007-05-31 Cowan David J Pth agonists
JP2007522214A (ja) 2004-02-11 2007-08-09 スミスクライン・ビーチャム・コーポレイション Pthアゴニスト
ITMI20041440A1 (it) 2004-07-19 2004-10-19 Abiogen Pharma Spa Peptidi analoghi del pth-1-11
CA2621264A1 (en) 2005-09-06 2007-11-15 Zelos Therapeutics, Inc. Parathyroid hormone analogues and methods of use
EP1961765A1 (en) 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
MX353986B (es) * 2007-08-01 2017-11-06 Massachusetts Gen Hospital Metodos de analisis y seleccion usando receptores acoplados a proteina g y composiciones relacionadas.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070111946A1 (en) * 1998-10-22 2007-05-17 Gardella Thomas J Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
WO2003009804A2 (en) * 2001-07-23 2003-02-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
WO2004067021A1 (en) * 2003-01-24 2004-08-12 Gardella Thomas J Conformationally constrained parathyroid hormone (pth) analogs with lactam bridges

Also Published As

Publication number Publication date
WO2010128521A3 (en) 2011-03-10
KR101451470B1 (ko) 2014-10-15
JP2012524775A (ja) 2012-10-18
US8383581B2 (en) 2013-02-26
IL215625A (en) 2016-12-29
WO2010128521A2 (en) 2010-11-11
EA022212B1 (ru) 2015-11-30
EA201171292A1 (ru) 2012-05-30
AU2010245642A1 (en) 2011-10-27
CA2757874C (en) 2016-02-16
KR20120034606A (ko) 2012-04-12
BRPI1008103A2 (pt) 2016-05-03
NZ595437A (en) 2014-03-28
EP2421893A2 (en) 2012-02-29
MX2011010968A (es) 2012-01-19
IL215625A0 (en) 2012-01-31
JP5744844B2 (ja) 2015-07-08
SG174532A1 (en) 2011-10-28
CA2757874A1 (en) 2010-11-11
ZA201107078B (en) 2014-03-26
US20120108496A1 (en) 2012-05-03

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