KR20120034606A - 부갑상선호르몬(ｐｔｈ) 수용체 작용물질로서의 단쇄 펩티드 - Google Patents
부갑상선호르몬(ｐｔｈ) 수용체 작용물질로서의 단쇄 펩티드 Download PDFInfo
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Abstract
본 발명은 부갑상선 호르몬(PTH/ PTH-1) 수용체 작용물질로서 주로 작용하는 다음의 화학식 1 의 신규한 단쇄 펩티드(short-chain peptide)를 제공한다. 이러한 단쇄 펩티드는 단백질 분해에 대해 증가된 안정성을 나타낸다. 대부분의 단쇄 펩티드는 (생체 외에서) 24 시간까지 안정적이었고, (생체 외에서) 랫 펩신 및 산성의 위 pH 와 같은 GIT 효소 및 간 마이크로솜에 대비하여 증가된 안정성을 나타냄을 발견하였다. 증가된 대사 안정성 때문에, 부갑상선 기능 저하증, 및 골다공증 및 폐경후 골다공증과 같은 골량 감소에 의해 특징지어지는 질병의 치료/예방 및 골 회복을 촉진시키기 위해 몇몇의 단쇄 펩티드를 비 경구 투여 외에 경구 투여할 수 있다.
화학식 1
A-Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10-Z11-Z12-Z13-Z14-Z15-B
화학식 1
A-Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10-Z11-Z12-Z13-Z14-Z15-B
Description
본 발명은 일반적인 화학식 1 의 PTH 수용체 작용물질로서의 신규한 단쇄 펩티드, 이의 약제학적으로 허용되는 염 및 이를 포함하는 약제학적 조성물에 관한 것이다.
화학식 1
A-Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10-Z11-Z12-Z13-Z14-Z15-B
본 발명은 또한 일반적인 화학식 1 의 화합물, 이의 약제학적으로 허용되는 염 및 이를 포함하는 약제학적 조성물을 제조하는 방법에 관한 것이다.
골다공증은 골량(bone mass), 골밀도(bone mineral density : BMD), 골강도(bone strength)의 감소에 의해 특징지어지거나 골절의 위험성을 증가시키는 것과 연관된 골격 질환이다.(Lane J. M. 등의, Clin. Orthop. Relat. Res., 372, 2000, 139-150). 대부분의 골다공증성 골절은 척추골, 고관절 또는 대퇴골에서 발생한다. 이러한 골절은 통증, 지속적인 부동 상태(long-lasting immobility)와 저조한 회복력 때문에 삶의 질을 심하게 손상시킨다. 골(bone)은 몇몇의 상이한 세포 유형을 포함한다. 조골세포(골 형성)는 세포 주위의 세포외 환경에 존재하는 미네랄로부터 새로운 골을 형성한다. 파골세포(osteoclast)(골 손실)는 세포외 메트릭스로 골 내에 구성된 미네랄을 방출하여 오래된 골을 제거한다. 충분한 새로운 골을 형성하는 것과 오래된 골을 제거하는 것 사이의 균형은 골에게 아주 유익한 특성을 주는 작용이다. 골다공증은 골을 형성하는 비율보다 골을 재흡수하는 비율이 클 때 발생한다(Seeman E. 등의, N. Engl. J. Med., 354(21), 2006, 2250-2261). 에스트로겐이 파골세포 수명을 변화시키기 때문에, 폐경 후 에스트로겐 결핍증은 여성에게 있어서 골다공증의 가장 일반적인 원인이다. 골다공증 진행에 있어서의 그 밖의 주요한 위험 요인은 저 칼슘 섭취, 비타민 D 결핍증, 제 1 형 당뇨병(type-1 diabetes), 류마티스 관절염, 항경련제 및 코르티코스테로이드류와 같은 양의 장기간 복용, 남성에게 있어서의 낮은 테스토스테론 농도를 포함한다(Cole Z. A. 등의 Curr. Rheumatol. Rep., 10(2), 2008, 92-96; Harvey, N.등의, Curr. Rheumatol. Rep., 5(1), 2003, 75-81).
골다공증을 가진 환자는 골절 회복을 촉진시키는 새로운 치료 또는 이러한 질병과 연관된 골절을 예방하거나 줄이는 치료로부터 이익을 볼 수 있다(Lindsay R., Lancet, 341(8848), 1993, 801-805). 현재는 에스트로겐, 랄록시펜(raloxifene)(에스트로겐 수용체 조절인자), 칼시토닌 및 비스포스포네이트(bisphosphonates)(에티드로네이트, 알렌드로네이트 및 리세드로네이트)가 이들의 골 재흡수 작용을 감소시킴으로써 이러한 질병의 치료에 다양한 수준의 성공률로 이러한 질병의 치료에 사용되고 있지만, 현재는 골다공증에 대한 효과적인 치유법은 없다(Recker R. R., J. Clin. Endocrinol. Metab., 1993, 76(1), 14-16).
천연의 인체(human) 부갑상선 호르몬(PTH)는 골과 신장에서 직접적인 작용을 통해서 인체에서 칼슘 항상성(calcium homeostasis)의 가장 주요한 조절인자로서 작용하는 84 아미노산 폴리펩티드이다(Kronenberg H. M., Bringhurst F. R., Nussbaum S. R., Jupner H., Abou-Samra A. B., In Handbook of Experimental Pharmacology, Mundy, G. R., and Martin, T. J., (eds), pp. 185-201, Springer-Verlag, Heidelberg (1993)). 갑상선으로부터 PTH 합성 및 방출은 혈청에서 주로 칼슘 농도를 조절한다 ; 낮은 농도에서는 호르몬의 합성과 방출을 자극하고 높은 농도에서는 호르몬의 합성과 방출을 억제한다. 결과적으로 PTH 는 혈액 내로 칼슘의 진입을 직접적으로 또는 간접적으로 촉진하여서 혈청에서의 칼슘 농도를 유지한다. PTH 는 비타민 D 의 활성형을 신장에서 합성하여 위장에서의 칼슘의 흡수에 기여한다. PTH 는 파골세포(골 재흡수 세포)의 분화를 간접적으로 자극하여서 골로부터 칼슘의 재흡수를 촉진시킨다. 비경구경로를 통한 PTH 의 투여는 골밀도(BMD), 골강도를 유효하게 증가시키고, 골다공증 환자에게 새로운 골다공성 골절의 발생을 감소시킨다(Greenspan S. L.등의, Ann. Intern. Med., 146(5), 2007, 326-339; Neer R. M., et al., N. Engl. J. Med., 344, 2001, 1434-1441).
PTH 는 수많은 조직, 가장 풍부하게 신장, 골 및 성장판 연골흡수세포에서 발현된 세포 표면 PTH 수용체와 이의 상호작용을 통하여 주로 이러한 모든 영향을 준다(Lanske B., et al., Crit. Rev. Eukaryot. Gene Expr., 8, 1998, 297-320). PTH 수용체는 세크레틴, 칼시토닌 및 글루카곤과 같은 펩티드 호르몬에 결합하는 수많은 다른 수용체와 일차구조와 유사하다 ; 이러한 수용체는 동시에 G-단백질 연결 수용체(G-protein coupled receptors : GPCR) 패밀리 B(family B) 라고 명명된 별개의 패밀리(distinct family)를 형성한다(Kolakowski L. F., Receptor Channels, 2, 1994, 1-7). GPCR 은 C-터미널 말단(C-terminal tail) 및 루프 사이에 오는 세븐 멤브레인-스패닝 α-헬릭스(seven membrane-spanning α-helices)의 막근접 도메인(juxtamembrane domain)(J-domain)에 연결되어 있는 100-160 잔기의 세포외 N-터미널 도메인을 포함한다(Donnelly D., FEBS Letts., 409, 1997, 431-436). 클래스 B(Class B) GPCRs 는 일반적으로 30-40 개의 아미노산인 중간 크기의 내인성 펩티드 리간드(endogenous peptide ligands)에 의해 활성화 된다(Hoare, S. R. J., Drug. Discovery Today, 10, 2005, 423-427). 클래스 B GPCRs 와 상호작용하는 펩티드 리간드의 일반적인 메커니즘은 알려졌고 흔히 '두 개의 도메인 모델(two-domain model)'라고 명명된다. 펩티드의 C-터미널 부분은 수용체의 N-도메인에 결합하고, 수용체에 리간드의 결합을 확인하고 N-터미널 리간드 영역은 J-도메인에 결합하고 이러한 상호작용은 수용체를 활성화시키고 세포내 신호전달(intracellular signaling)을 자극한다(Ji T. H.,등의, J. Biol. Chem., 273, 1988, 17299-17302; Hjorth, S. A. 등의, Regulatory Peptides, 64, 1996, 70).
PTH 는 nM 범위에서 친화력을 갖는 PTH 수용체에 결합한다 ; 리간드-결합 수용체(ligand-occupied receptor)는 이종삼합체(heterotrimeric) GTP-결합 단백질(G 단백질)을 매개자로 포함하는 매커니즘을 통해서 세포내 작동체 효소(effector enzyme)에 세포막을 가로질러 신호를 전달한다. PTH 펩티드에 반응하여 PTH 수용체에 의해 활성화된 일차 세포내 작용체 효소는 아데니닐시클라아제(adenylyl cyclase : AC)이다(Goltzman D., J. Bone Miner. Res., 15(3), 2000, 605-608). 따라서 PTH 는 골의 재형성(bone remolding)에 관여하는 저조하게 특징지어진 다운스트림 세포내 과정(downstream cellular processes)을 조절하는, 두번째 전달자로서 고리형 아데노신 모노포스페이트(cyclic adenosine monophosphate : cAMP)가 증가되도록 유도한다(Juppner H., et al., Science, 254, 1991, 1024-1026). 세포내 칼슘, 단백질 키나아제 C 의 포스포리파아제 C-의존적이고 독립적인 활성을 증가시키는 것과 같은 이러한 수용체의 또 다른 신호전달 과정은 기재되어 있다. PTH 가 혈액에서 칼슘 및 인산염 농도를 조절하고, 강력한 동화작용(골-형성) 효과를 나타내기 때문에, 부갑상선 호르몬 및 이의 유도체는 골다공증의 치료에 잠재적인 치료제로서 제시되고 있다(Slovik D. M. 등의, J. Bone Miner. Res., 1, 1986, 377-381; Dempster D. W. 등의 Endocr. Rev., 14, 1993, 690-709).
합성한 PTH(1-34)는 대부분의 세포-기반 검정 시스템(cell-based assay systems)에서 완전한 생체활성(bioactivity)를 나타내고, 동물의 골밀도에서 강한 동화작용을 가지고, 최근에는 폐경후 골다공성 여성에 있어서의 골절의 위험을 감소시키는 것으로 나타나고 있다. 페경후 여성에서의 인체실험에서, 저 농도의 PTH(1-34)를 매일 피하 주사한 결과, 척추 골절의 정도를 현저하게 감소시키면서 척추 및 대퇴골 경부에서의 인상적인 골 형성의 결과를 나타내었다(Neer R. M. 등의, N. Engl. J. Med., 344, 2001, 1434-1441; Dempster D. W. 등의, Endocr. Rev., 14, 1993, 690-709). 이러한 임상적 데이터는 골다공증에 대해서 실험한 가장 효과적인 인자 중의 하나가 PTH 임을 나타낸다. 상표명 Forteo(Eli Lilly)라는 이름으로 테리파라티드 아세테이트(teriparatide acetate) 형태의 PTH(1-34)는 골다공증의 치료제로 승인되었다.
PTH 유도체는 아미노산 치환체를 갖는 폴리펩티드를 포함하고, 완전한-길이의 분자(full-length molecule)에 비하여 길이가 줄었다. PTH(1-34)의 N과 C-터미널 둘다 절단된 형태는 연구되고 있다. 게다가 절단된 폴리펩티드 내에서의 아미노산 치환체는 또한 연구되고 있다(Azurani A.,등의, J. Biol. Chem., 271, 1996, 14931-14936). PTH 펩티드의 15-34 도메인에서의 잔기는 수용체 결합 친화력에 중요하게 기여하는 반면에, PTH 펩티드의 N-터미널 1-14 아미노산은 수용체의 활성에 기여하는 것으로 알려졌다(Naussbaum S. R.등의, J. Biol. Chem., 255, 1980, 10183-10187; Gardella T. J., 등의, Endocrinology, 132, 1993, 2024-2030; Takasu H., 등의, Biochemistry, 38, 1999, 13453-13460; Hoare S. R. J., 등의, J. Biol. Chem., 276, 2001, 7741-7753; Luck M. D., 등의, Molecular Endocrinology, 13, 1999, 670-680). 고리화(cyclised) PTH(1-17), PTH(1-28) 및 PTH(1-31)와 같은 절단된 PTH(1-34) 유도체는 대부분 검정 시스템에서 유효하고 골 형성을 증진시킨다(Whitfield J. F. 등의, J. Bone Miner. Res., 12, 1997, 1246-1252; WO 2007 / 130113 A2; WO 2008 / 068487; Whitefild J. F. 등의, Calcif. Tissue Int., 56, 1995, 227-231; Rixon R. H. 등의, J. Bone Miner. Res., 9, 1994, 1179-1189; Whitfield J. F. 등의, Trends Pharmacol. Sci., 16, 1995, 372-386; Whitfield J. F. 등의, Calcif. Tissue Int., 58, 1996, 81-87). 그러나 이러한 펩티드는 효율적으로 경구 투여하기에서 여전히 너무 크다. 보다 작은 PTH 작용물질의 발견은 골다공증에 대한 새로운 치료를 발전시킬 수 있는 중요한 진전이 될 것이다.
불행히도 PTH 펩티드의 큰 분자량으로 인하여 PTH 펩티드의 합성도 기술적으로 어렵고 따라서 비용도 많이 들어서 오직 가능한 투여 방법은 주사 경로(injection route)이기 때문에 PTH 펩티드의 치료상의 적용은 한정되어 있다. 게다가 PTH 는 프로테아제 공격에 매우 민감하여서, 이의 낮은 안정성 때문에 저온에서 저장해야 한다. 이러한 기술적인 한계뿐만 아니라, 독성데이터에서 나타나는 칼슘의 일시적인 부동화 및 고칼슘혈증으로 내약성(tolerability)이 제한되고, 특히 발암연구에서의 바람직하지 못한 결과(투여 및 치료의 기간에 따른 골육종의 위험의 증가)는 PTH(1-34)의 신중한 사용을 유도한다(Vahle J. L., Toxicol. Pathos., 32(4), 2004, 426-438; Whitfiel J. F., Medscape Womens Health, 6(5), 2001, 7; Kuijpers G., BMJ, 324(7335), 2002, 435-436). 반면에, 예를 들어 PTH 의 처음 14 개의 아미노산 PTH(1-14) 및 11개의 아미노산 PTH(1-11)으로 구성된 이러한 저분자량 펩티드는 동물 모델에서 불활성이거나 매우 낮은 생물학적 활성을 나타냄이 입증되었다(Tregear G. W. 등의, Endocrinology, 93, 1973, 1349-1353; Gardella T. J. 등의, J. Biol. Chem., 266, 1991, 13141-13146).
따라서, 지난 10년 동안 개선된 생물학적 프로파일(profile), 바람직하게 경구적으로 생체이용가능하고 프로테아제 저항성 있고 합성하기 쉽고 보다 높은 안전성 지표(safety index)를 갖는 PTH-유도된 저분자량 펩티드의 개발에 연구가 집중되고 있다. 최근에, 특정 부위에서의 나선 구조를 안정화시킨 비천연 아미노산을 도입함으로서 저분자량 펩티드의 활성도가 개선될 수 있음을 발견하였다. 예를 들어서 PTH(1-11) 유사체([Ala3, Gln10, Arg11]-PTH(1-11), [Ala3, Gln10, Har11]-PTH(1-11) 및 [Aib1 ,3; Gln10; Har11]-PTH(1-11)) 및 [AC5C1, Aib3, Gln10, Har11, Ala12, Trp14]PTH(1-14)과 같은 PTH(1-14) 유사체는 nM 범위에서 cAMP 를 활성화시킨다(WO 03/009804; WO 04/093902). PTH-유사 활성도를 갖는 저분자량 펩티드를 발견하기 위해 몇몇 실험들이 진행되고 있었다(Reidhaar-olson J. F.등의, Mol. Cell. Endocrinology., 160, 2000, 135-147; Shimizu M. 등의, J. Biol. Chem., 275, 2000, 21836-21843; Shimizu M. 등의, Endocrinology, 142, 2001, 3068-3074; Shimizu N.등의., J. Biol. Chem., 276, 2001, 49003-49012; WO 03/009804). 11 개 정도의 아미노산으로 구성된 짧은 유사체(처음 1-11 잔기의 PTH 펩티드 유사체, Seq. ID NO. 2)가 비록 (생체 외에서) 낮은 효력으로 PTH 수용체를 활성화시킬 수 있으나(WO 04/067021), 동물 모델(생체 내)에서 이러한 유사체의 골-동화작용(bone-anabolic activity)은 보고된 바 없다. 결론적으로, (생체 외에서) PTH 수용체의 cAMP-신호전달 경로(cAMP-signalling pathway)에서의 작용물질 활성도만으로는 생체 내에서 골-동화작용을 모두 예측할 수는 없다.
최근 연구에서, 비천연 아미노산을 갖는 N-터미널 서열(처음 1-14 또는 1-15 잔기, Seq ID. No. 3 및 4)의 PTH(1-34) 펩티드의 상동하는 치환체(유도체)가 다양한 정도의 분포도에서 강한 PTH 수용체 효능적 활성(agonistic activity), 보다 특이적으로 PTH-1 수용체 효능적 활성을 갖는 신규한 클래스의 단쇄 펩티드를 발견하는 결과를 가져옴을 우리는 놀랍게도 발견하게 되었다. 단백질 분해효소에 대항하여 작용과 안정성의 지속을 증진시키기 위해서, 우리는 비천연 아미노산을 갖는 부위-특이적으로 변형된 단쇄 펩티드(site-specifically modified the short-chain peptides)를 획득하였고 대사적으로 안정화되고 매우 효능이 강한 단쇄 펩티드를 식별하는데 성공하였다. 몇몇의 단쇄 펩티드는 경구 투여에서도 PTH-1 수용체 효능적 활성을 유지하면서 생물학적 이용도(bioavailability)를 나타내었다.
다음에 나타낸 PTH(1-34) 서열 배열은 1차 구조상의 관계를 나타낸다 ;
PTH (1-34): 1SVSEIQLMHNLGKH14LNSMERVEWLRKKLQDVHNF34 (Seq. ID No: 1) ;
PTH (1-11): 1SVSEIQLMHNL11 (Seq. ID No: 2) ;
PTH (1-14): 1SVSEIQLMHNLGKH14 (Seq. ID No: 3) ;
PTH (1-15): 1SVSEIQLMHNLGKHL15 (Seq. ID No: 4).
아미노산에 대한 단일문자 약자는 Zubay, G., Biochemistry 2nd ed., 1988, MacMillan Publishing, New York, p. 33 에서 찾을 수 있다.
선행기술
형태적으로 강요된 부갑상선 호르몬 펩티드(PTH) 유사체 및 유도체의 시리즈(series)는 일반적인 화학식 Xaa1-Xaa11 및/또는 Xaa1-Xaa14 로 알려졌다 ; 여기에서 몇몇 유사체와 함께 Xaa1-Xaa11 및/또는 Xaa1-Xaa14 는 PTH 펩티드의 처음 1-11 및/또는 1-14 N-터미널 잔기를 나타내고, Xaa1 및 Xaa3 는 Aib 또는 AC5C를 나타내고, Xaa8 은 Nle 를 나타내고 ; Xaa10 은 Q 를 나타내고, Xaa11 은 Har 를 나타내고, Xaa12 는 Ala를 나타내며 Xaa14는 W를 나타낸다(WO 03 / 009804 A2; US 2006 / 7153951 B2; US 2007 / 0117157 A1; US 2007 / 0203071 A1; US 2006 / 0019902 A1; US 2007 / 0161569 A1; US 2007 / 0111946 A1; Gardella T. J. 등의, J. Biol. Chem. 2000, 275, 21836-21843; Gardella T. J.등의, Endocrinology, 2001, 142, 3068-3074; Gardella T. J. 등의, J. Biol. Chem., 2001, 52, 49003-49012). 최근에 몇몇 비-펩티드 PTH 작용물질은 문헌에 또한 보고된 바가 있으나, 이들 중 어디에서도 생체 내 동물 모델에서의 잠재적인 가능성을 갖는 것으로 발견된 것은 없었다(US 2007 / 0099940 A1; WO 2005 / 077918 A1).
발명의 요약
본 발명은 PTH/PTH-1 수용체에 대해서 상이한 정도의 친화력을 갖고 골다공증 치료에 유용한, PTH 수용체의 작용물질로서 기능하는 신규한 단쇄 펩티드 그룹(group)에 관한 것이다. 이러한 단쇄 펩티드는 하기한 바와 같이 일반적인 화학식 1 에 나타내었다. 본 발명의 단쇄 펩티드는 부갑상선 기능 저하증, 및 골다공증, 폐경후 골다공증과 같은 골밀도 감소 또는 골 손실에 의해 특징지어지는 질병의 치료 또는 예방에 유용하고 골 회복(bone repair)에 유용하다.
본 발명은 주로 PTH/PTH-1 수용체 작용물질로서 작용하는 화학식 1 의 신규한 단쇄 펩티드를 제공한다. 이러한 단쇄 펩티드는 단백질 분해 효소에 대항하는 증가된 대사 안정성을 나타낸다. 대부분의 단쇄 펩티드는 (생체 외에서) 24 시간까지 랫 혈장에서 안정적이고, (생체 외에서) 펩신 및 산성의 위(stomach) pH 와 같은 GIT 효소 및 또한 간 마이크로솜(liver microsomes)에 대한 증가된 안정성을 나타내었다. 비경구 투여 외에 증가된 대사 안정성(metabolic stability) 때문에, 이러한 단쇄 펩티드 중 몇몇을 또한 경구투여로 전달할 수 있다.
바람직한 실시형태
본 발명의 바람직한 실시형태는 골 장애의 치료/경감/조절하기에 적절한, 일반적인 화학식 1 의 신규한 단쇄 펩티드, 이들의 합성과 관련된 신규한 매개자, 이들의 약제학적으로 허용되는 염 및 이들 또는 이들의 혼합물을 포함하는 약제학적 조성물에 관한 것이다.
보다 바람직한 실시형태에서, 본 발명은 일반적인 화학식 1 의 단쇄 펩티드, 이의 약제학적으로 허용되는 염, 용매화합물 및 약제학적으로 허용되는 담체, 용매화합물, 희석제, 부형제 및 이들의 제조과정에서 일반적으로 사용되는 그밖의 매체(media)를 갖는 이들 혼합물을 함유하는 약제학적 조성물을 제공한다.
보다 추가적으로 바람직한 실시형태에서, 본 발명은 화학식 1 의 단쇄 펩티드 또는 이들의 약제학적으로 허용되는 조성물을 이러한 치료를 필요로 하는 포유동물에게 독성을 나타내지 않는 약제학적으로 유효량을 투여하여, 골다공증 및 연관된 골 장애를 치료 및/또는 예방하고 새로운 골 형성을 촉진하는 제제로서의 본 발명의 신규한 단쇄 펩티드의 용도를 제공한다.
본 발명의 상세한 설명
본 발명에 따라, PTH-1 수용체 효능적 활성을 나타내는, 구조적인 화학식 1 을 갖는 합성된 단쇄 펩티드를 나타내었다. 대부분의 단쇄 펩티드는 (생체 외에서) 24시간까지 랫 혈장에서 안정적이고, (생체 외에서) 펩신 및 산성의 위(stomach) pH 와 같은 GIT 효소 및 또한 간 마이크로솜(liver microsomes)에 대한 증가된 안정성을 나타냄을 발견함으로써 이러한 단쇄 펩티드는 단백질 분해(proteolytic cleavage)에 대한 증가된 대사 안정성을 나타낸다. 대사 안정성의 증가로 인하여 이러한 단쇄 펩티드의 몇몇은 부갑상선 기능 저하증, 골다공증, 폐경후 골다공증과 같은 골량 감소로 특징지어지는 질병의 치료/예방 및 골 회복의 촉진을 위해, 경구 투여로 또한 전달될 수 있다.
따라서, 본 발명은 다음의 화학식 1 을 갖는 PTH 수용체 작용물질로서의 신규한 단쇄 펩티드를 나타낸다 ;
화학식 1
A-Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10-Z11-Z12-Z13-Z14-Z15-B
여기에서,
A 는 -NH-R1 또는 R3-CO-NH-기를 나타내고
여기에서
R1 은 수소, 비오틴, 임의로 치환된 선형 또는 가지형 (C1 -18) 알킬 사슬, 또는 피로글루탐산(Pyr), Pro(P), 알파-메틸-프롤린(αMe-P), Val(V), N-메틸-발린(NMe-V), 알파-메틸-발린(αMe-V), Lys(비오틴), Lys(알킬), Lys(아세틸)과 같은 적절한 아미노산을 나타내고 ;
R3 은 임의로 치환된 선형 또는 가지형 (C1 -18) 알킬 사슬, (C1-6)알콕시, (C3-C6)시클로알킬, 아릴, 헤테로아릴 또는 아릴알킬기 중에서 선택한 것이다.
바람직한 실시형태에서, 아릴기는 페닐, 나프틸, 인다닐, 플루오레닐 또는 비페닐 기 중에서 선택한 것이고 ; 헤테로아릴기는 피리딜, 티에닐, 푸릴, 이미다졸일, 벤조푸라닐기 중에서 선택한 것이고 ; 아릴알킬기는 명세서에 기재된 바와 같이 알킬기에 아릴기를 부착한 것이다.
B는 -COOR2, -CONHR2 또는 CH2OR2 을 나타내고, 여기에서 R2 는 H, 또는 Val(V), 알파-메틸-발린(αMe-V), Lys(비오틴), Lys(알킬), Lys(아세틸) 등과 같은 적절한 아미노산을 나타내고 ;
각각의 Z1, Z3 및 Z12 는 동일하거나 상이할 수 있으며, 독립적으로 Ser(S), 알파-메틸-세린(αMe-S), Val(V), 알파-메틸-발린(αMe-V), Pro(P), 알파-메틸-프롤린(αMe-P), Gly(G), Ala(A), α-아미노-이소부티르산(Aib), 1-아미노 시클로프로판 카르복실산(AC3C), 1-아미노-시클로펜탄카르복실산(AC5C), 1-아미노-시클로헥산카르복실산(AC6C)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않은 아미노산을 나타내고 :
Z2는 Val(V) 또는 αMe-Val(αMe-V)을 나타내고 ;
각각의 Z4, Z6 및 Z10은 동일하거나 상이할 수 있으며, 독립적으로 Glu(E), 호모글루탐산(HoGlu), 2-아미노-4-시아노부탄산(Abu(CN)), Asp(D), Asn(N), Gln(Q), Aib 을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ;
각각의 Z5, Z7 및 Z9 은 동일하거나 상이할 수 있으며, 독립적으로 Leu(L), Ile(I), Nle(노르류신), Nva(노르발린), HoLeu(호모류신), Abu(CN), His(H), Phe(F), 하기한 바와 같은 알파-메틸-페닐알라닌(-α-Me-Phe-), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-) 또는 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-) 또는 2-플루오로페닐알라닌(-2F-Phe-)기를 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ;
Z8 은 Met, N-메틸-Met((NMe)M), 알파-메틸-Met(αMe-M), 알파-메틸-발린(αMe-V), Leu, Nle, N-메틸-Nle((NMe)Nle), 알파-메틸-노르류신(αMe-Nle), Nva, HoLeu, 에티오닌(EtMet), 셀레노메티오닌(SMet), Val 을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ;
Z11 및 Z13 은 동일하거나 상이할 수 있으며, 독립적으로 Aib, Pro(P), αMe-Pro, 리신(K), 리신-비오틴(K(비오틴)), 리신(니트로)[K(NO2)], 아르기닌(R), 아르기닌(니트로)[(Arg(NO2)], 호모아르기닌(Har), 오르니틴(Orn), 오르니틴(니트로)[Orn(NO2)], 시트룰린(Cit), 호모시트룰린(HoCit), Phe(F), 알파-메틸-페닐알라닌(-α-Me-Phe-), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-) 또는 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-) 또는 2-플루오로페닐알라닌(-2F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ;
Z14 는 하기한 바와 같은 2'-에틸-4'-메톡시-비페닐알라닌(Bip(OMe)), α-메틸화 Bip(OMe)[αMe-Bip(OMe)], αMe-Trp, 알파-메틸-페닐알라닌(-α-Me-Phe-), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-), 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-) 또는 2-플루오로페닐알라닌(-2F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내며 ;
Z15 는 존재하거나 존재하지 않는다. Z15 가 존재할 때 2-아미노-5-페닐발레르산(APPA) 또는 2-아미노-2-메틸-5-페닐발레르산(α-Me-APPA)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타낸다 ;
본 발명의 실시형태에 있어서, 본 발명은 하기한 화학식 1의 변형된 PTH 유사체를 제공한다 ;
여기에서 A는 -NH-R1 또는 R3-CO-NH-기를 나타내고, R1 은 수소, 비오틴, 또는 피로글루탐산(Pyr), Pro(P), Val(V)과 같은 적절한 아미노산을 나타내고, 모든 부호는 하기에 나타낸 바와 같다 ;
본 발명의 또 다른 실시형태에 있어서, 본 발명은 R3 은 임의로 치환된 선형 또는 가지형 (C1 -18) 알킬 사슬로부터 선택한 화학식 1 의 화합물을 제공하고 모든 부호는 하기에 나타낸 바와 같다 ;
본 발명의 또 다른 실시형태에 있어서, 본 발명은 B 가 -COOR2, -CONHR2 를 나타내고, R2 는 H, 또는 Val(V), 알파-메틸-발린(αMe-V), Lys(비오틴)과 같은 적절한 아미노산을 나타내는 화학식 1 의 화합물을 제공하고 모든 부호는 하기에 나타낸 바와 같다 ;
본 발명의 또 다른 실시형태에 있어서, 본 발명은 화학식 1 의 화합물을 제공한다 ;
각각의 Z1, Z3 및 Z12 는 동일하거나 상이할 수 있으며, 독립적으로 Ala(A), α-아미노-이소부티르산(Aib), 1-아미노 시클로프로판 카르복실산(AC3C), 1-아미노-시클로펜탄카르복실산(AC5C), 1-아미노-시클로헥산카르복실산(AC6C)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않은 아미노산을 나타내고 모든 부호는 하기에 나타낸 바와 같다.
본 발명의 또 다른 실시형태에 있어서, 본 발명은 다음의 화학식 1의 화합물을 제공한다 ;
Z2 는 Val(V)으로 구성된 기로부터 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않은 아미노산을 나타내고 모든 부호는 하기에 나타낸 바와 같다.
본 발명의 추가적인 실시형태에 있어서, 본 발명은 다음의 화학식 1 의 화합물을 제공한다 ;
각각의 Z4, Z6 및 Z10은 동일하거나 상이할 수 있으며, 독립적으로 Glu(E), Gln(Q), Aib 을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고, 모든 부호는 하기에 나타낸 바와 같다.
본 발명의 또 다른 실시형태에 있어서, 본 발명은 다음의 화학식 1 의 화합물을 제공한다 ;
각각의 Z5, Z7 및 Z9 은 동일하거나 상이할 수 있으며, 독립적으로 Leu(L), Ile(I), Nle, HoLeu(호모류신), His(H), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-) 또는 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고, 모든 부호는 하기에 나타낸 바와 같다 ;
본 발명의 또 다른 실시형태에 있어서, 본 발명은 다음의 화학식 1 의 화합물을 제공한다 ;
Z8 은 Met, 알파-메틸-Met(αMe-M), Nle, N-메틸-Nle((NMe)Nle)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고, 모든 부호는 하기에 나타낸 바와 같다.
본 발명의 또 다른 실시형태에 있어서, 본 발명은 다음의 화학식 1 의 화합물을 제공한다 ;
각각의 Z11 및 Z13 은 동일하거나 상이할 수 있으며, 독립적으로 Aib, αMe-Pro, 리신(K), 리신-비오틴(K(비오틴)), K(NO2), 아르기닌(R), Arg(NO2), 호모아르기닌(Har), 오르니틴(Orn), Orn(NO2), 시트룰린(Cit), 호모시트룰린(HoCit), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-), 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고, 모든 부호는 하기에 나타낸 바와 같다.
본 발명의 또 다른 실시형태에 있어서, 본 발명은 다음의 화학식 1 의 화합물을 제공한다 ;
Z14 는 2'-에틸-4'-메톡시-비페닐알라닌(Bip(OMe)), α-메틸화 Bip(OMe)[αMe-Bip(OMe)], 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-), 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고, 모든 부호는 하기에 나타낸 바와 같다 ;
본 발명의 또 다른 실시형태에 있어서, 본 발명은 다음의 화학식 1 의 화합물을 제공한다 ;
Z15 는 존재하고, 2-아미노-5-페닐발레르산(APPA) 또는 2-아미노-2-메틸-5-페닐발레르산(α-Me-APPA)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타낸다.
바람직한 실시형태에 있어서, 본 발명은 다음의 화학식 1 의 변형된 PTH 유사체를 나타낸다 ;
A 는 -NH-R1 또는 R3-CO-NH-기를 나타내고, 여기에서 R1 은 수소, 비오틴, 피로글루탐산(Pyr), Pro(P), Val(V)과 같은 적절한 아미노산을 나타내고 ; R3 은 임의로 치환된 선형 또는 가지형(C1 -18) 알킬 사슬로부터 선택한 것이고 ; B는 -COOR2, -CONHR2를 나타내고, 여기에서 R2 는 상기에 나타낸 바와 같고 ; 각각의 Z1, Z3 및 Z12 는 동일하거나 상이할 수 있으며, 독립적으로 Ala(A), α-아미노-이소부티르산(Aib), 1-아미노 시클로프로판 카르복실산(AC3C), 1-아미노-시클로펜탄카르복실산(AC5C), 1-아미노-시클로헥산카르복실산(AC6C)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않은 아미노산을 나타내고 ; Z2 는 Val(V)을 나타내고 ; 각각의 Z4, Z6 및 Z10 은 동일하거나 상이할 수 있으며, 독립적으로 Glu(E), Gln(Q), Aib 을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ; Z5, Z7 및 Z9 은 동일하거나 상이할 수 있으며, 독립적으로 Leu(L), Ile(I), Nle, HoLeu(호모류신), His(H), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-), 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ; Z8 은 Met, 알파-메틸-Met(αMe-M), Nle, N-메틸-Nle((NMe)Nle)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ; Z11 및 Z13 은 동일하거나 상이할 수 있으며, 독립적으로 Aib, αMe-Pro, 리신(K), 리신-비오틴(K(비오틴)), K(NO2), 아르기닌(R), Arg(NO2), 호모아르기닌(Har), 오르니틴(Orn), Orn(NO2), 시트룰린(Cit), 호모시트룰린(HoCit), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-), 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ; Z14 는 2'-에틸-4'-메톡시-비페닐알라닌(Bip(OMe)), α-메틸화 Bip(OMe)[αMe-Bip(OMe)], 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-), 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내며 ; Z15 가 존재할 때, Z15 는 2-아미노-5-페닐발레르산(APPA) 또는 2-아미노-2-메틸-5-페닐발레르산(α-Me-APPA)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타낸다.
상기에 나타낸 기 중에서 치환기는 히드록시, 옥소, 할로, 티오(thio), 니트로, 아미노, 알킬, 알콕시, 할로알킬 또는 할로알콕시기 중에서 선택한 것이다.
용어 '천연 아미노산(natural amino acid)' 은 자연에 존재하는 모든 20 가지 아미노산을 나타낸다.
용어 '비천연 아미노산(unnatural amino acid 또는 non-natural amino acid 아미노산)'은 바람직하게 L-Ala 가 D-Ala 로 교체되는 것과 같이 L-아미노산이 이에 상응하는 D-아미노산으로 교체되거나, 다음의 a 또는 b 에 의한 L 또는 D 아미노산, 아미노 알킬 산(amino alkyl acids)의 적절한 변형물을 나타낸다 ;
a) Ala 이 α-메틸 Ala(Aib)로 치환되거나, Met가 α-메틸 Met 로 교체되는 것과 같은 α-알킬화 반응 ; 또는
b) 할로겐, (C1-C3)알킬, 아릴기를 갖는 방향족 아미노산 곁사슬로 치환되거나, 보다 특이적으로 Phe이 할로 Phe(halo Phe)로 교체되는 것과 같이 아미노산의 잔기의 치환.
본원의 명세서에 기재된 다양한 기, 라디칼 및 치환기는 다음의 단락에 기재하였다.
본원에서 기재된, 단독으로 또는 다른 라디칼과 결합된 용어 '알킬' 은 메틸, 에틸, n-프로필, 이소-프로필, n-부틸, sec-부틸, tert-부틸, 아밀, t-아밀, n-펜틸, n-헥실, iso-헥실, 헵틸, 옥틸, 데실, 테트라데실, 옥타데실 등과 같은 1 내지 8 의 탄소를 함유하는 선형 또는 가지형 라디칼을 나타낸다.
본원에 기재된, 단독으로 또는 다른 라디칼과 결합된 용어 '시클로알킬' 은 시클로프로필, 시클로부틸, 시클로펜틸, 시클로헥실, 시클로헵틸 등과 같은 3 내지 7 의 탄소를 함유하는 라디칼을 나타낸다.
다른 방법으로 나타내지 않는 한, 본원에서 단독으로 또는 다른 기의 부분으로 사용된 용어 '아미노산' 은 제한없이 아미노기 및 'α' 탄소로 언급된 동일한 탄소에 연결된 카르복실기를 포함한다.
'α' 탄소에서의 완전한 'S' 입체배치는 'L' 또는 천연의 입체배치로서 일반적으로 나타낸다. 'α' 탄소에서의 'R' 입체배치는 'D' 아미노산으로 일반적으로 나타내었다. 수소 또는 메틸과 같이 'α-치환기'가 둘 다 동일한 경우에는 아미노산은 Gly 또는 Aib 이고, 비대칭이 아니다.
본 발명은 단쇄 펩티드에 관하여 주로 예를 들었지만, PTH 효능적 활성을 모방할 수 있는 능력을 유지할 수 있다면 잔기 사이의 펩티드 결합은 비-펩티드 결합으로 교체될 수 있음을 또한 이해할 수 있을 것이다. 본 분야의 숙련자는 티오아미드 결합 형성, 아미드 결합의 N-메틸화 등과 같은 적절한 변형물을 인지할 수 있다.
생물학적 활성도가 유지된다면, 아미노산의 보존성 치환을 포함하는 서열은 또한 본 발명의 범위 내에 속한다.
본 발명의 화합물은 다음으로 한정되지 않지만 이를 포함하는 펩티드 아미드 및 비-아미드 및 펩티드 유사체를 포함함을 분명하게 이해할 수 있을 것이다 ;
a) 하나 또는 그 이상의 아미노산이 이에 상응하는 D-아미노산으로 교체된 화합물. 본 분야의 숙련자는 레트로-인버소 아미노산 서열(retro-inverso amino acid sequences)을 표준실험 방법으로 합성할 수 있음을 인식할 수 있을 것이다 ; 예를 들어 Chorev M., Acc. Chem. Res., 26, 1993, 266-273 참조 ;
b) 펩티드 결합이 대사적인 분해에 보다 잘 견딜 수 있는 구조로 교체된 펩티드 모방성 화합물(peptidomimetic compound). 예를 들어 Olson G. L., et al., J. Med. Chem., 36(21), 1993, 3039-3049 참조 ; 및
c) 예를 들어 Ala 가 Aib 로 또는 Met 가 α-Me-Met 로 교체된 것과 같이 각각의 아미노산이 유사한 구조로 교체된 화합물.
일반적으로, 이러한 교체 가능한 구조물의 사용은, 이들이 생리학적 조건 하에서 분해에 보다 저항성을 갖거나 또는 생물학적 이용도를 증진시키기 때문에 신체에서 상당히 긴 반감기를 제공할 수 있다.
상세한 설명에 기재된 천연 아미노산의 일반적인 하나의 문자 코드 및 세 문자 코드는 Har(호모아르기닌), Nle(노르류신), α-아미노 이소부티르산(Aib)으로 사용된 바와 같이 다른 비천연 아미노산의 세 문자 코드에서도 일반적으로 허용가능하게 사용할 수 있다.
용어 'PTH 수용체 조절인자 또는 작용물질'은 PTH-1 및/또는 PTH-2 수용체에서 cAMP 생산과 같이 하위 신호전달(downstream signaling event)을 조절할 수 있는 PTH-1 및/또는 PTH-2 수용체의 능력을 변화시키도록 작용할 수 있는 화합물을 나타낸다. 수용체 조절인자의 예로서 작용물질, 부분적인 작용물질, 반대 작용물질(inverse agonist) 및 알로스테릭 강화제(allosteric potentiator)를 포함한다.
본 발명에 따라서, 본원에 기재된 합성된 분리된(isolated) 단쇄 펩티드는 주로 PTH 수용체 작용물질로서 작용한다. 이러한 합성된 단쇄 펩티드는 생체외에서 1-1000 nM 농도의 범위로 UMR-106 세포에서 생체 외 바람직한 PTH 수용체의 효능적 활성을 나타내었다. PTH 수용체의 효능적 활성은 실험 화합물에 의해 방출된 cAMP 의 양을 평가하여 측정하였다. 몇몇의 제조된 단쇄 펩티드는 생체내 OVX 랫 모델에서 실험하였을 때 BMD 및/또는 골 강도에서의 증가를 나타내었고, 따라서 이들 펩티드는 골다공증의 치료 및 예방에 이상적인 치료학적 후보물질이 될 수 있다. 이러한 새로운 클래스(class)의 단쇄 펩티드는 경구 또는 그밖의 비외과적인 경로(non-invasive routes) 또는 비경구의 투여 방법에 의해 투여될 수 있다.
본 발명은 이러한 단쇄 펩티드가 단독으로 또는 조합물(combination)로서 사용된 화학식 1 의 약제학적 조성물 및 이러한 단쇄 펩티드를 사용하는 방법을 제공한다. 특히, 본 발명은 약제학적으로 허용되는 담체와 화학식 1 의 단쇄 펩티드를 단독으로 또는 조합물로 약제학적 유효량을 포함하는 약제학적 조성물을 제공한다. 게다가 본 발명은 화학식 1 의 단쇄 펩티드 또는 이들의 조합물의 약제학적 유효량을 치료를 필요로 하는 포유동물, 예를 들어 인체 및 환자에게 투여하여, 골다공증, 특히 초기 골다공증, 내분비성 골다공증(endocrine osteoporosis), 폐경후 골다공증, 유전적이고 선천적인 형태의 골다공증의 진행 또는 발현을 치료하거나 지연시키는 방법을 제공한다.
단쇄
펩티드의 제조방법 :
본 발명의 단쇄 펩티드를 제조하기 위해서 펩티드 합성 분야에서 숙련된 숙련자에게 공지된 몇몇의 합성 방법을 사용할 수 있다. 모든 부호는 하기에 나타낸 바와 같은 화학식 1 의 단쇄 펩티드는 펩티드 합성 분야에서 숙련자에게 공지된 일반적인 방법 또는 본 분야의 숙련자에 의해서 예측될 수 있는 변형된 방법과 함께 하기에 나타낸 방법을 사용하여서 합성할 수 있다. 언급된 방법은 하기에 나타낸 방법을 포함하지만 이로 한정되지 않는다.
본원에 기재된 이의 단쇄 펩티드는 G. Barany & R. B. Merrifield "The peptides: Analysis, synthesis, Biology" ; Volume 2- "Special methods in peptide synthesis, Part A", pp. 3-284, E. Gross & J. Meienhofer, Eds., Academic Press, New York, 1980; and in J. M. Stewart and J. D. Young, "Solid-phase peptide synthesis" 2nd Ed., Pierce chemical Co., Rockford, Il, 1984. 에 기재된 바와 같이 용액상(solution-phase)(바람직하게, Boc-화학 ; M. Bodansky, A. Bodansky, "The practice of peptide synthesis", Springer-Verlag, Berlim, 1984; E. Gross, J. Meinhofer, "The peptide synthesis, analysis, biology", Vol. 1, Academic Press, London, 1979) 및/또는 고체상 기술 둘 다의 적절한 변형된 방법을 사용하여 화학적 합성에 의해 생산될 수 있다.
본 발명의 단쇄 펩티드를 제조하기 위한 바람직한 방법은 Fmoc-기반 SPPS 처리방법을 사용을 기반으로 하며, 여기에서 만약 존재한다면 아미노산 잔기의 일시적인 보호를 위해서, tert-부톡시카르보닐(Boc), tert-부틸(But), 트리틸(Trt)기(도 2)와 같은 산성 이치환성 보호기(acid labile protecting groups)가 결합된 Fmoc(9-플루오레닐메톡시카르보닐)기를 사용하였다(예를 들어 E. Atherton & R.C. Sheppard, "The Fluorenylmethoxycarbonyl amino protecting group", in "The peptides: Analysis, synthesis, Biology"; Volume 9 - "Special methods in peptide synthesis, Part C", pp. 1-38, S. Undenfriend & J. Meienhofer, Eds., Academic Press, San Diego, 1987 를 참고).
단쇄 펩티드를 펩티드의 C-터미널 형태로 시작되는 불수용성 폴리머 지지체(수지 : resin)로 순차적인 방법으로 합성할 수 있다. 실시형태에 있어서, 합성은 아미드, 에스테르 또는 에테르 결합의 형성을 통해서 수지에 펩티드의 C-터미널 아미노산을 결합시켜서 시작된다. 이는 각각 C-터미널 아미드, 카르복실산 또는 알콜과 같은 결과적으로 발생한 펩티드의 최종적인 방출을 가능하게 한다.
Fmoc-기반 SPPS 에서, 수지로부터 펩티드의 때이른 분해 또는 곁사슬 보호기의 탈보호 없이, 20 % 피페리딘 용액과 같은 적절한 염기를 사용하여 α-아미노 보호기가 합성되는 동안에 선택적으로 제거될 수 있는 것과 같이 이러한 합성에서 사용된 C-터미널 아미노산 및 그 밖의 아미노산은 (만약 존재한다면) 별도로 보호된(직교의 보호 : orthogonal protection) 이들의 α-아미노기 및 곁사슬 기능을 가져야 하고 산성 이치환성 보호기로 일반적으로 보호되어야 한다.
아미노산의 결합은 수지에 부착된 N-터미널 아미노산의 비블럭화 된(unblocked) α-아미노기로 활성 에스테르 및 이의 반응으로써 이의 카르복실기의 활성에 의해서 실시된다. 모든 결합 및 탈보호 반응 후에는 펩티딜-수지는 DMF, DCM 및 디에틸 에테르와 같은 초과량의 용액으로 세척하였다. α-아미노산 기의 탈보호 및 결합의 연속된 과정을 바람직한 펩티드 서열이 조립될 때까지 반복한다(도식 1). 그리고 난 다음에 부가 반응(side reaction)을 제한하기 위해서 일반적으로 적절한 스캐빈져(scavenger)의 존재 하에서 적절한 분해 혼합물을 사용하여 곁사슬 기능에 수반되는 탈보호를 갖는 수지로부터 펩티드를 분해하였다. 결과적으로 생성된 펩티드를 역상 HPLC 로 최종적으로 정제하였다.
최종 펩티드에 대한 전구체(precursor)로서 요구된 펩티딜-수지의 합성물은 상업적으로 이용가능한 교차-결합된 폴리스티렌 폴리머 수지(미국 캘리포니아 샌디에고 Novabiochem)를 활용하였다. 본 발명에서 C-터미널 아미노산을 이미 부착되었거나 부착되지 않은 Fmoc-PAL-PEG-PS 수지, 4-(2',4'-디메톡시페닐-Fmoc-아미노메틸)-페녹시아세틸-p-메틸 벤즈하이드릴아민 수지(Fmoc-Rink 아미드 MBHA 수지), 2-클로로-트리틸-클로라이드 수지 또는 p-벤질옥시벤질 알콜 수지(HMP 수지)를 우선적으로 사용하였다. C-터미널 아미노산이 부착되지 않았다면, DIPCDI로 이러한 반응으로 형성된 Fmoc-보호된 아미노산의 HOBt 활성 에스테르에 의해서 부착시킬 수 있다. 2-클로로-트리틸 수지의 경우에는, DIPEA를 사용하여 첫번째 Fmoc-보호된 아미노산을 결합시켰다. 다음의 아미노산 조합을 위해서 펩티딜 수지의 N-터미널 보호는 10-20% 피페리딘 용액을 사용하여 선택적으로 탈보호되었다. 모든 결합 및 탈보호반응 후에, 아미노산 및 결합 시약의 잉여물을 DMF, DCM 및 에테르로 세척하여 제거하였다. 각각의 DIPCDI/HOBt 또는 DIPCDI/HOAT 로부터 생성된 HOBt 또는 HOAT 활성 에스테르를 사용하여 다음의 아미노산의 결합을 성취할 수 있었다. 특히 소수성 아미노산 또는 부피가 큰(bulky) 곁사슬 보호기를 가진 아미노산의 몇몇의 어려운 결합의 경우에는, DIPEA 와 같은 첨가물과 함께 HBTU, PyBOP 또는 TBTU 와 같은 매우 효율적인 결합제를 사용하여서 결합을 완전하게 달성할 수 있다.
본원에 기재된 단쇄 펩티드의 합성은 Fmoc/t-부틸 보호 방법을 활용하여 CS-Bio 또는 AAPPTEC 펩티드 합성장치(synthesizer)와 같은 회분식(batchwise) 또는 연속식 펩티드 합성 장치(continuous flow peptide synthesis apparatus)를 사용하여서 실행할 수 있다. 상이한 위치에서 존재하는 비-천연의 상업적이지 않은 아미노산을 본 분야에서 공지된 하나 또는 그 이상의 방법을 사용하여 펩티드 사슬에 결합시켰다. 하나의 처리방법에 있어서, 적절한 문헌의 절차를 사용하여 Fmoc-보호된 비-천연 아미노산을 용액에서 제조하였다. 예를 들어서, 문헌의 변형된 절차를 사용하여 좋은 거울상 이성질체 순도로 L-피로글루탐삼으로부터 상기에 기재한 Fmoc-보호된 APPA 유사체를 제조하였다(Betsbrugge J.V.등의, Tetrahedron, 54, 1988, 1753-1762).
비대칭성 스트레이터 합성방법(asymmetric Strecker synthesis)을 사용하여 Fmoc-보호된 α-메틸화 아미노산을 제조하였다(Boesten, W.H.J., et al., Org. Lett., 3(8), 2001, 1121-1124; Cativiela C., Diaz-de-villegas M. D., Tetrahedran Asymmetry, 9, 1988, 3517-3599). 그리고 난 다음에 결과적으로 생성된 유도체를 펩티드의 순차적인 합성에서 사용하였다. 그 대신에, 합성 유기화학 제조방법을 사용하여서 직접적으로 수지에 요구된 비-천연 아미노산을 합성하였고, 선형 펩티드 사슬을 합성하였다.
문헌에 기재된 표준 분해 절차에서의 적절한 변이(variation)를 사용하여 이들 각각의 단쇄 펩티드에 대한 펩티드-수지 전구체를 분해하고 탈보호시킬 수 있다(King D.S.,등의, Int. J. Peptide Protein Res., 1990, 36, 255-266). 본 발명에 사용된 바람직한 방법은 스캐빈져로서 물 및 TIPS의 존재 하에서 TFA 분해 혼합물을 사용하였다. 일반적으로, 펩티딜-수지를 실온에서 1.5-4 시간 동안 TFA/물/TIPS(95:2.5:2.5)에서 배양하였다(incubate). 그리고 난 다음에 분해된 수지를 여과하여 제거하고 환산압력 하에서 TFA 용액을 농축시키고 건조시켰다. 결과적으로 생성된 조 펩티드(crude peptide)를 침전시키거나 Et2O 로 세척하거나, 조제용(preparative) HPLC로 정제하기 위해 DMF 또는 50 % 수성 아세트산에 직접적으로 재용해시켰다.
원하는 순도를 갖는 단쇄 펩티드를 조제용 HPLC를 사용하여 정제하여 수득할 수 있다. 조 펩티드 용액을 semi-Prep 컬럼(Luna 10m; C18; 100 A), 치수 250 X 50 mm)에 주입시켰고, 용출액을 220 nm 로 PDA 검출기로 모니터하면서 40 mL/분의 유량으로 둘 다 0.1% 의 TFA 에 완충시킨 물에 용해시킨 ACN 의 선형 구배(linear gradient)로 용출시켰다. 정제된 단쇄 펩티드의 구조는 전기 스프레이 질량 분석기(Electrospray Mass Spectroscopy : ES-MS) 분석으로 확인할 수 있다.
제조된 모든 펩티드는 Prep-HPLC 정제 후에 반대이온(counter ion)으로서 TFA 와 함께 트리플루오로-아세테이트 염으로서 분리하였다. 그러나 적절한 이온 교환 수지 베드, 바람직하게 음이온-교환 수지 Dowex SBR P(Cl) 또는 당량 기초 음이온-교환 수지를 통해 통과시켜서 몇몇의 펩티드를 탈염시키기 위해 주입하였다. 몇몇의 경우에, 희석된 아세트산 완충용액으로 용출시켜 적절한 이온-교환 수지를 통과시킴으로써 TFA 반대이온을 아세테이트 이온으로 교체시켰다. 펩티드의 히드로클로라이드 염 제조를 위해서, 제조방법의 마지막 단계에서, 아세테이트 염을 갖는 선별된 펩티드를 4M HCl로 처리하였다. 결과적으로 생성된 용액을 막 필터(0.2 ㎛)으로 여과시키고 그 다음에 백색 내지 오프 화이트(off-white)의 HCL 염을 수득하기 위해서 동결건조시켰다. 본 분야에서의 숙련자에게 잘 알려진 범위 내에서 다음의 유사한 기술 및/또는 이러한 적절한 변형된 방법으로 본 발명의 단쇄 펩티드의 또 다른 적절한 약제학적으로 허용되는 염을 제조하였다.
도 1 : 랫 PTH-1 R 검정에서의 생체 외에서의 PTH(1-34) (A) 및 Seq. ID No. 111 (B)의 DRC 및 EC50 측정(방출된 cAMP 의 양으로 측정된 효능적 활성)
도 2 : 단쇄 펩티드의 Fmoc 기반-고체상 펩티드합성(SPPS)에서 사용된 직교하여 보호된 아미노산의 예
도 3 : OVX 암컷 랫의 생체 내에서 Seq. ID No. 111 (A : 혈청 Ca2 + 농도의 증가율 ; B: 혈청 PO4 농도의 감소율 %)
도 4 : Seq. ID No. 111 및 PTH(1-34)로 6 주 치료한 후의 OVX랫에서의 생화학적 파라미터 및 대퇴골 무게의 변화
도 5 : Seq. ID No. 111 로 6 주 치료한 후의 OVX 랫에서의 대퇴골 조직학적 단면도
도 6 : Seq. ID No. 111 로 6 주 치료한 후의 OVX 랫에서의 경골 조직학적 단면도
도 7 : Seq. ID No. 111 로 6 주 치료한 후의 OVX 랫에서의 요추 조직학적 단면도
도 2 : 단쇄 펩티드의 Fmoc 기반-고체상 펩티드합성(SPPS)에서 사용된 직교하여 보호된 아미노산의 예
도 3 : OVX 암컷 랫의 생체 내에서 Seq. ID No. 111 (A : 혈청 Ca2 + 농도의 증가율 ; B: 혈청 PO4 농도의 감소율 %)
도 4 : Seq. ID No. 111 및 PTH(1-34)로 6 주 치료한 후의 OVX랫에서의 생화학적 파라미터 및 대퇴골 무게의 변화
도 5 : Seq. ID No. 111 로 6 주 치료한 후의 OVX 랫에서의 대퇴골 조직학적 단면도
도 6 : Seq. ID No. 111 로 6 주 치료한 후의 OVX 랫에서의 경골 조직학적 단면도
도 7 : Seq. ID No. 111 로 6 주 치료한 후의 OVX 랫에서의 요추 조직학적 단면도
SPPS
처리 방법을 사용한
단쇄
펩티드의 일반적인 제조방법 :
수지에서의
단쇄
펩티드의 조립 :
충분한 양(50-100mg)의 Fmoc-PAL-PEG-PS 수지 또는 Fmoc-Rink 아미드 MBHA 수지를 0.5-0.6 mmol/g 으로 로딩(loading)하여 2-10분 동안 DMF(1-10 mL /100 mg 의 수지)에서 부풀렸다. DMF(10-30mL/100mg의 수지)에 용해시킨 10-30% 피페리딘으로 수지를 10-30분 동안 배양하여 수지에서 Fmoc-기를 제거하였다. 탈보호된 수지를 여과시키고 초과량의 DMF, DCM 및 에테르(50 ml X 4)로 세척하였다. 질소 대기 하에서 세척된 수지를 5분 동안 갓 증류된 DMF(1 mL / 100 mg 의 수지)에서 배양시켰다. DMF에 용해시킨 0.5 M 용액의 첫번째 Fmoc-보호된 아미노산(1-3 eq.), 예비 활성화된 HOBt(1-3 eq.) 및 DIPCDI(1-2 eq.)를 수지에 첨가하고 질소 대기 하에서 수지를 1-3시간 동안 교반시켰다. 정성 닌하이드린 시험(qualitative ninhydrin test)를 이용하여 결합의 완성을 모니터하였다. 첫 번째 아미노산을 결합시킨 후에, 수지를 DMF, DCM 및 디에틸 에테르(50 mL X 4)로 세척하였다. 다음의 아미노산의 결합을 위해서, 다음에 상기에 기재한 바와 같이 우선 10-20% 피페리딘 용액을 이용하여 수지와 결합된 첫번째 아미노산에서의 Fmoc-보호를 탈보호시킨 적절한 결합제를 사용하여서 Fmoc-보호된 두 번째 아미노산을 결합시켰다.
일반적인 도식 1과 같이 수지에서의 원하는 펩티드 잔기를 조립할 때까지 탈보호, 세척, 결합 및 세척의 반복된 사이클을 실행하였다. 최종적으로 상기한 바와 같은 20% 피페리딘 처리에 의해서 상기에 제조된 Fmoc-보호된 펩티딜-수지를 탈보호시켰고, 펩티딜-수지를 DMF, DCM 및 디에틸 에테르(50 mL X 4)로 세척하였다. 원하는 펩티드를 포함하는 수지를 질소 압력 하에서 10-15 분 동안 건조시키고 분해/탈보호시키기 위해 주입시켰다.
본 분야의 숙련자에게 알려진 범위 내에서 상기의 프로토콜 및 이의 적절한 변형방법을 사용하여, Fmoc-SPPS 처리 방법을 사용하여 본 발명에서 의도된 단쇄 펩티드를 제조하였다. 최종적으로, 단쇄 펩티드가 결합된 수지를 분해하고 탈보호시키고 다음의 부분에 기재된 프로토콜을 이용하여 정제하고 특징지었다.
펩티드 서열
ID
.
No
.
18 의
자동화된 고체상 합성의 대표적인 예 :
H
2
N
-(AC
5
C)-V-(AC
5
C)-EIQLMHQ-Har-(α
Me
-
Pro
)-K-(α-
Me
-
Phe
)-
CONH
2
.
선형의 단쇄 펩티드 H2N-(AC5C)-V-(AC5C)-EIQLMHQ-Har-(αMe-Pro)-K-(α-Me-Phe)-PAL-PEG-PS 를 Fmoc 고체상 펩티드 합성(SPPS) 처리방법(도식 2)을 사용하여 자동화된 CS-Bio 536 PepSynthesiserTM 에서 조립하였다. Fmoc 아미노산 및 2-(1H-벤조트리아졸-1-일)-1,1,3,3-테트라메틸우로늄테트라플루오로보레이트(TBTU)를 우리병에 넣어서 같이 포장하고, 합성장치의 아미노산 모듈(module)에 두었다.
디이소프로필에틸아민(DIPEA ; 0.9 M) 및 DMF 의 원액(stock solution)을 건조 질소 대기 하에서 시약병에 보관처리하다. 수지 Fmoc-PAL-PEG-PS(0.38 mmol/g; 1g)를 (1 시간) 진공에서 P2O5 상에서 건조시키고, 갓 증류된 DMF(5 mL)에서 부풀렸다. 부풀어진 수지를 유리컬럼(glass column)에 슬러리(slurry)상태로 보관처리 하였고 합성 장치에 두었다. 모든 합성 사이클을 표 1 에 나타낸 바와 같이 5 mL min-1의 유량으로 실시하였다. 수지를 10 분 동안 갓 증류된 DMF 로 세척하였다. Fmoc기의 탈보호를 10 분 동안 DMF 에 용해시킨 20 % 피페리딘으로 실행하고, 탈보호 여부를 304 nm 에서 컬럼 용출액의 UV 검출로 모니터하였다.
[표 1]
고체상 펩티드 합성의 자동화된 사이클
각각의 사이클 당 15 분으로 3 번의 보조 세척 사이클 및 증류된 DMF 세척 사이클로 과량의 피페리딘을 제거하였다. 아미노기를 Fmoc-아미노산(4 당량)으로 처리하고, DIPEA(8 당량)의 존재 하에서 TBTU(3.9 당량)으로 미리 활성화시키고 120 분 동안 재순환시켰다. 각각의 사이클에서 10 분 동안 4 번의 보조 세척 사이클 및 증류된 DMF 세척 사이클을 통해 컬럼 및 루프로부터 과량의 아미노산 및 수용성 부산물을 제거하였다. 더욱이, 선형 펩티드의 완전한 조립을 위해서 합성 사이클(탈보호, 세척, 아실화 및 세척)을 반복하였다. 터미널 Fmoc기를 제거하기 위해서 15 분 동안 DMF 에 용해시킨 20 % 피페리딘으로 최종적인 탈보호 사이클을 실시하고 세척 사이클(10 X 4 분)을 실시하였다. 완전한 펩티드-수지를 소결 유리 여과기(sintered glass filter)로 정제하고, DMF, DCM, 메탄올, DMF 및 디에틸 에테르(각각 100 mL)로 연속적으로 3 번 세척하였다. P2O5 (2 hr) 상 진공에서 펩티드-수지를 건조시키고 -20 ℃ 에서 저장하였다.
도식 2 :
Seq
.
ID
.
No
.
18 의
SPPS
수지 결합된 펩티드의 N-터미널 유리 아미노기를 확인하기 위해서 닌하이드린 시험을 실시하였다. 남색의 용액 및 수지 비드(bead)의 출현은 수지에서 유리 아미노기의 존재를 나타내고 양성 반응(positive test)로 간주된다.
수지 결합된 펩티드의 순도를 측정하기 위해서 소규모 분해를 실시하였다. 실온에서 90 분 동안 서서히 가끔씩 저어주면서 건조된 펩티드-수지(ca 10-mg)를 TFA, 물, 트리이소프로필실란(95: 2.5: 2.5 v/v)의 혼합물(1 mL)로 처리하였다. 수지를 정제하고 아무것도 섞지 않은 TFA(1 mL)로 철저히 세척하고, 전체 여과액을 환산 압력 하에서 증발시켰다. 잔류한 TFA 를 디에틸 에테르(2 mL)로 3 번 공비혼합 시켰다. 수득한 잔류물을 증류수(2 mL)에 현탁시키고 수성층을 디에틸 에테르(3 mL)로 3 번 추출하였다. 조펩티드 H2N-(AC5C)-V-(AC5C)-EIQLMHQ-Har-(αMe-Pro)-K-(α-Me-Phe)-CONH2 를 산출하기 위해서 수성층을 분리하고 동결건조시켰다. 동결건조된 펩티드 H2N-(AC5C)-V-(AC5C)-EIQLMHQ-Har-(αMe-Pro)-K-(α-Me-Phe)-CONH2 를 0.1 % 수성 TFA(ca 1mg /1 mL)에 용해시키고 이의 순도를 RP-HPLC 로 분석하였고 전기 스프레이 이온화 질량 분석법(ESI-MS)으로 특징지었다. 순도 퍼센트 : 90 %(조 펩티드). ESI-MS; H2N-(AC5C)-V-(AC5C)-EIQLMHQ-Har-(αMe-Pro)-K-(α-Me-Phe)-CONH2 에 대한 계산치: 1790 (M+), 1812 (M+Na+) 및 1828 (M+K+); 측정치 (m/z): 1790 (M+), 1812 (M+Na+) and 1828 (M+K+).
본 분야의 숙련자의 범위 내에서 상기의 프로토콜 및 이의 적절한 변형 방법을 사용하여, Fmoc-SPPS 처리방법을 사용하여 본 발명의 원하는 단쇄 펩티드를 제조하였다. 더욱이, 하기의 프로토콜을 사용하여 수지 결합된 단쇄 펩티드를 분해하고 탈보호하고 정제하고 특징지었다.
분해 및
탈보호
:
원하는 단쇄 펩티드를 다음과 같이 TFA 분해 혼합물로 처리하여 이들 각각의 펩티딜-수지로부터 분해하고 탈보호시켰다. TFA/물/트리이소프로필실란(95:2.5: 2.5)의 용액(10 mL / 100 mg 의 펩티딜-수지)을 펩티딜-수지에 첨가하고 혼합물을 가끔씩 저어주면서 실온에서 유지시켰다. 수지를 정제하고 분해 혼합물로 세척하고 결합된 여과액을 건조시키기 위해 증발시켰다. 수득한 잔류물을 10 mL 의 물에 용해시키고 수성층을 에테르(각각 20 mL)로 3 번 추출하고 최종적으로 수성층을 동결건조시켰다. 동결건조 후에 수득한 조 펩티드를 다음과 같이 조제용 HPLC 로 정제하였다 :
조
단쇄
펩티드의 조제용
HPLC
정제 :
조제용 HPLC 를 Shimadzu LC-8A 액체 크로마토그래피에서 실시하였다. DMF 또는 물에 용해시킨 조 펩티드의 용액을 semi-Prep 컬럼(Luna 10m; C18; 100 A0), 치수 250 X 50 mm 에 주입시키고, 용출액을 220 nm 로 PDA 검출기로 모니터하면서 15-50 mL 의 유량으로 둘 다 0.1 % TFA 에 완충시킨 물에 용해시킨 ACN 의 선형 구배로 용출시켰다. 0.1 % TFA 로 완충시킨 일반적인 구배(gradient)의 20 % 내지 70 % 의 물-ACN 혼합물을 1 분당 1 % 구배로 50 분 동안 사용하였다. 용출된 원하는 산물을 단일 10-20 mL 분획(fraction)으로 수집하고, 각각의 HPLC 분획물을 냉동건조시켜 순수한 단쇄 펩티드를 비결정성 백색의 분말로서 수득하였다.
정제된
단쇄
펩티드의
HPLC
분석 :
상기한 바와 같이 조제용 HPLC 로 정제한 후에, Shimadzu LC-10AD 분석 HPLC(analytical HPLC) 시스템에서 분석 RP-HPLC 로 각각의 펩티드를 분석하였다. 단쇄 펩티드의 분석 HPLC 분석을 위해서 0.1 % TFA 및 ACN 완충용액의 선형 구배로 Luna 5μ; C18; 100 Å 치수 250 X 4.6 mm 컬럼을 사용하였고, 크로마토그램의 수집(acquisition)을 PDA 검출기로 220 nm 에서 실시하였다.
질량 분석기에 의한 특성 :
플로 인젝션 분석(flow injection) 또는 LC/MS 방법으로 전기 스프레이 이온화 질량 분석법으로 각각의 펩티드를 특징지었다. 양이온 및 음이온 전기 스프레이 방법으로 삼단계 사중극자(Triple quadrupole) 질량 분석기[API-3000 (캐나다 MDS-SCIES로부터 입수)]를 모든 분석에서 사용하였다. 단위 분별(unit resolution)로 작동되고, 사중 극자의 질량 범위에서 모든 정밀 검사 데이터를 획득하였다. 모든 경우에 있어서, 실험적으로 측정된 분자량은 0.5 달톤의 측정된 단일 동위 원소 분자량(monoisotopic molecular weight)이었다. 질량 크로마토그램의 수량화를 Analyst 1.4.1 소프트웨어를 사용하여 실행하였다.
다른 일반적으로 공지된 기술 및 이의 적절한 변형된 방법과 마찬가지로 본원에 기재된 합성 방법을 사용하여, 다음의 신규한 단쇄 펩티드를 제조하였다[표 2(A-S)]. 표 2의 목록은 본 발명에 따라서 제조될 수 있는 다양한 그룹의 단쇄 펩티드를 나타내고, 이러한 단쇄 펩티드의 최소한의 명백한 변형물을 포함함을 예측할 수 있다. 그러나, 이러한 기재로 어떤 방법으로든 본 발명의 범위를 한정하는 것으로 이해해서는 안된다. 표 2(A-S)에서, 본 발명의 신규한 단쇄 펩티드를 이의 상응하는 Seq ID NO 로 리스트를 작성하였다.
[표 2]
A : 제조된
단쇄
펩티드 목록
B: 제조된
단쇄
펩티드 목록
C : 제조된
단쇄
펩티드 목록
D : 제조된
단쇄
펩티드 목록
E : 제조된
단쇄
펩티드 목록
F : 제조된
단쇄
펩티드 목록
G : 제조된
단쇄
펩티드 목록
2H : 제조된
단쇄
펩티드 목록
I : 제조된
단쇄
펩티드 목록
J : 제조된
단쇄
펩티드 목록
K : 제조된
단쇄
펩티드 목록
L : 제조된
단쇄
펩티드 목록
M : 제조된
단쇄
펩티드 목록
N : 제조된
단쇄
펩티드 목록
O: 제조된
단쇄
펩티드 목록
P : 제조된
단쇄
펩티드 목록
Q : 제조된
단쇄
펩티드 목록
R : 제조된
단쇄
펩티드 목록
S : 제조된
단쇄
펩티드 목록
신규한
단쇄
펩티드의 생체 외 및
생체 내에서의
연구 :
상기한 바와 같이 제조한 단쇄 펩티드를 다음과 같이 실험 하였다 ;
a) 생체 외에서 랫 PTH-1 R 작용물질 활성도(UMR-106 세포에서의 사이클릭 AMP 측정) ;
b) 인체 혈장, 인공 위액(simulated gastric fluid), 장액(intestinal fluid) 및 간 마이크로솜에서의 펩티드 안정성(탈체 : ex-vivo) ; 및
c) OVX 랫 모델에서 생체 내에서 실험한 항-골다공증 활성도.
a) 생체 외에서 랫
PTH
-1 R 작용물질 활성도(
UMR
-106 세포에서의
사이클릭
AMP 측정) :
PTHR 은 GPCR 이고 PTHR 작용물질은 이에 결합하고 신호전달을 통해서 아데닐산 시클라아제(adenylate cyclase)를 활성화시키고 세포 내에서 cAMP 의 농도를 증가시킨다. 신규한 화합물의 효능적 활성을 모니터하기 위해서, 랫 PTHR, 특히 PTH-1R 이 내부에 발현된 UMR-106 랫의 골육종 세포(Source ATCC)를 다양한 농도의 실험 화합물로 처리하였고, 방출된 cAMP 의 양을 측정하였다.
UMR-106 세포를 10 % 소태아 혈청(FBS) 및 1X 펜스트렙(Penstrep)을 함유하는 DMEM 영양 배지(nutrition media)(Sigma)에 배양시켰다. 배양시킨 세포를 96-웰 조직 배양 플레이트에 10 % FBS 로 보충한 DMEM 배지에 웰 당 5 x 104 밀도의 세포로 도말하고 유효성 검정(efficacy assays)하기 전에 2 일 동안 성장시켰다. 검정하는 날에, 성장 배지를 석션(suction)으로 조심스럽게 제거하고 세포를 200 ㎕ 의 PBS 로 한번 세척하고, 90 ㎕ 반응 배지[플레인 DMEM 배지, 저농도의 글루코스, 0.1 % BSA(Sigma) 및 1 mM 3-이소부틸-1-메틸크산틴(Sigma)]에서 30 분 동안 37 ℃ 에서 배양하고 난 다음에 90 ㎕ 의 반응 배지에서 10 ㎕ 의 실험 화합물(농도 1, 10 및 100 nM)로 처리하고 30 분 동안 실온에서 배양하였다. 배지를 흡입시키고, 60 ㎕ 의 세포용출 완충용액(lysis buffer), 효소 공여체(ED) 기질 시약(enzyme donor substrate reagent)(40 ㎕) 및 cAMP-항체 시약을 첨가하고 플레이트를 1 시간 동안 실온에서 배양시켰다. 게다가, 효소 수용체(EA) 시약(enzyme acceptor reagent)을 첨가하고 2 시간 동안 실온에서 배양한 후에 Top Count L-Max 발광 측정 장치(Luminometer)(각 웰 마다 20초씩 판독)로 루미네센스(luminescence)를 판독하였다. cAMP 표준 곡선으로부터 방출된 cAMP 의 양을 측정하였다. 데이터는 대조군[매질(vehicle) : 물]의 백분률로 계산하고 평균 ±SD 로 표현하였다. 생체 외에서 PTH-1 수용체 효능적 활성을 갖는 대표적인 펩티드를 표 3 에 열거하였다. 선별된 실험 화합물의 EC50 를 측정하기 위해서 비-선형 회귀 곡선 피트(curve fit)[시그모이달 도스(Sigmoidal dose)]로 데이터를 분석하였다(Carter P. H.,등의., PNAS, 2007, 104(16), 6846-6851; Merritt B. S., J. Cellular Physiology, 2005, 152(3), 520-528; Reid I. R., Am. J. Physiol. Endocrinol. Metab., 253, 1987, E45-E50).
[표 3]
b) 인체 혈장, 인공 위액, 장액 및 간
마이크로솜에서의
펩티드 안정성(
탈체
)
0, 2, 4, 6, 12 및 24 시간 동안(37 ℃ ; 50 mM 트리에탄올아민-HCL 완충용액 ; pH 7.8) 인체 혈청(7.5 ㎕) 또는 인공 위액(pH 1.5 : 조성 HCL, NaCl 및 펩신) 또는 인공 장액(pH 7. 5) 또는 인체 간 마이크로솜에 상이한 단쇄 펩티드(최종 농도 2 μM)를 배양하였다. 24 시간 동안 관찰하여 시간-의존성 분해(time-dependent degradation)가 가능하도록 하여 1 시간 내에 대략 PTH(1-34)의 50 % 분해를 제공하는 인체 혈장/인공 위액/인공 장액/인체 간 마이크로솜의 농도를 예비 실험에서 선별하였다. TFA/H2O (15 mL, 10% (v/v))를 첨가하여 반응을 종료하였다. 그리고 난 다음 반응 산물을 Vydac C18 분석컬럼(4.6 x 250-mm)에 적용시키고 난 다음 대부분의 분해 단편을 온전한(intact) 단쇄 펩티드로 부터 분리시켰다. 컬럼을 1 mL/분의 유량으로 TFA/H20 로 평형을 유지시켰다. 70 % 아세토니트릴/H2O 에 용해시킨 0.1% (v/v) TFA를 사용하여, 용출시킨 용매의 아세토니트릴 농도를 10 분 동안 0% 내지 28% 로 증가시키고 30 분 동안 28% 내지 42% 로 증가시켰다. ESI-MS 분석 전에 UV 검출기를 사용하여 206 nm 에서 흡광도를 모니터하였고, 정점(peak)을 수집하였다. 실험 펩티드에 대한 곡선 아래의 영역을 측정하였고, 이들의 대사산물 및 분해 퍼센트를 24 시간 이상 각각의 시점에서 측정하였다. (생체 외) 인체 혈장, 인공 위액, 인공 장액 및 간 마이크로솜에서 선별된 펩티드의 안정성 연구 결과를 표 4 에 나타내었다.
[표 4]
c)
생체내
OVX
랫 모델에서 실험한 항-골다공증 활성도 :
생체 내에서 실험 화합물(단쇄 펩티드)의 항-골다공증 활성도를 연구하기 위해 난소가 절출된 랫(ovariectomiced rat : OVX 랫)을 사용하였다. 난소 호르몬 결핍증 때문에 OVX 랫은 골감소증이 생겼다. 난소를 적출하고 14일이 되면 골감소증이 감지되었고 100일 후에는 증상이 더 증가되었고 그 다음에는 안정화되었다(Wronski T. J. 등의., Calcif. Tissue Int., 43(3), 1988, 179-183).
OVX
동물에서 골 표지자(
marker
) 및 조직형태계측에서 동화치료 효과를 증진시키는 자세한 연구 프로토콜 :
10 내지 11 주된 암컷 Wistar 랫(150-200 g)을 이용하였다. 조절된 온도(23℃ ± 3℃), 조명(12시간 : 12시간의 주-야간 사이클) 및 상대적인 습도(55 ± 10 %)로 공간에서 각기 환기된 케이지(cage)에서 동물을 키웠다. 동물은 랫 먹이 및 물에 자유롭게 접근할 수 있다. 이러한 연구를 실시하기 위한 동물의 사용에 대한 프로토콜은 재검토되었고 동물 실험 윤리 위원회(IAEC)에 의해 인가되었다.
연구를 시작하기 전에 식별을 위해서 피크르산으로 동물을 표지하고 2 일 동안 실험적인 실내 조건에 적응시켰다. 골다공증을 유도하기 위해서, 랫을 마취시키고 난소를 양쪽 다 적출하였다. 난소 절제술를 행하기 위해서, 동물의 옆구리 부위에 가까운 등쪽 옆 부위를 절개하였다. 그리고 난 다음에, 혈액 손실을 방지하기 위해서 혈관을 묶고 난소를 절개하였다. 절개 후에 결찰사(ligature)로 봉합하였다.
양쪽의 난소절제술 후에 동물을 4 주 동안 휴식을 취하게 하였다. 그리고 난 다음에 동물의 몸무게를 기초로 동물을 다른 그룹(n=9)으로 나누었다. 어떠한 치료도 하지 않는 대조군, 기준으로서의 PTH 및 실험 화합물(단쇄 펩티드)의 하나 또는 두 개의 그룹으로 이루어져 있다. 6주 동안 치료를 받았다. 치료 마지막 날에 소변을 모으기 위해서 단식시키고 실험 동물을 대사 케이지(metabolic cages)에 하룻밤 동안 두었다. 다음날 마지막으로 복용한지 24 시간이 지난 후에 혈액을 모으고 동물을 희생시켰다. 생화학적 파라미터 및 골 전환율(bone turnover) 파라미터에서의 변화(혈청에서 칼슘의 증가 및 인산염 농도, 산성 인산가수분해 효소 및 TRAP의 감소)를 소변과 혈청에서 평가하였다. 희생시킨 후에 온전한 대퇴골 및 경골을 적출하고 부착된 조직, 근육 및 힘줄을 제거하고 무게를 재고 포름 살린(formal saline)(10 % 포름알데히드 용액)에 모았다. 요추골(L5)를 절개하고 조심스럽게 깨끗하게 하고 포름 살린에 모았다. 대퇴골, 경골 및 요추골-5(L5)을 조직형태학적 평가를 위해 처리하였다(Zhang L., 등의l., Tohoku J Exp Med., 1998, 186(2), 131-41; Tanizawa T., 등의., Toxicol Lett., 1998,102, 399-403). 선별된 펩티드의 혈청에서의 칼슘 증가 및 인산염 농도(% 변화율 대 PTH)의 감소를 표 5 에 나타내었다.
[표 5]
PTH(1-34)(도 1A) 및 Seq. ID No. 111(도 1B)의 (랫 PTH-1 R 검정에서의) 생체 외 DRC 연구 데이터(EC50)을 대표적인 도면으로써 도 1 에 나타내었다. OVX 암컷 Wister 랫에서 경구 투여로 상이한 복용량(0.1/0.2/0.3/0.5 mg/kg)으로 Seq. ID. No. 111 ((AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2,6-F-Phe))로 6 주 치료한 후의 생체 내 DRC 연구 데이터를 대표적인 도면으로 도 3 에 나타내었다(도 3A : 혈청에서의 Ca2 + 농도의 증가율 % ; 도 3B : 혈청에서의 PO4 농도의 감소율 %). 도 4 는 Seq. ID No. 111 및 PTH(1-34)로 6 주 치료한 후의 OVX 랫에서의 생화학적 파라미터 및 대퇴골 무게의 변화를 도 4 에 나타내었다. Seq. ID No. 111 로 6 주 치료한 후에 OVX 랫에서 대퇴골, 경골 및 요추의 조직학적 단면도를 도 5, 6 및 7 에 나타내었다.
유용성 :
바람직한 실시형태에서, 본 발명은 UMR-106 세포에서 상이한 정도의 친화력(1-1000 nM 농도)을 갖는 PTH-1 수용체의 작용물질로서 작용하는 단쇄 펩티드를 제조하는 방법을 제공한다. PTH-1 수용체 효능적 활성을 실험 화합물에 의한 방출된 cAMP 의 양으로 평가하여 측정하였다(생체 외에서). OVX 마우스/랫 모델(생체 내)에서, 몇몇의 단쇄 펩티드는 골다공증의 치료 및 예방을 위한 골 성장 파라미터를 개선시켜 이상적인 치료상의 후보물질이 되었다.
본 발명의 신규한 단쇄 펩티드는 다양한 단백질 가수 분해 효소에 대비하여 증가된 안정성을 나타내었고, 이러한 증가된 안정성 및 단쇄 길이로 인하여 그 밖의 침습(invensive) 및 비-침습 경로의 투여와 함께 경구로 전달될 수 있다.
본 발명은 신규한 단쇄 펩티드를 공지된 적절한 부형제와 함께 적절한 약제학적으로 허용되는 조성물로 제형화시킬 수 있다.
일반적으로 이용되는 방법을 사용하여 약제학적 조성물을 제공한다. 바람직하게 조성물은 본 발명에 따른 유효량의 유효성분, 즉 화학식 1 의 단쇄 펩티드 단독 또는 조합물을 함유하는 단위 투여 형태(unit dosage form)이다. 본 분야에서 공지된 적절한 희석제, 안정제, 완충용액 등 중에서 선택한 적절한 부형제를 포함하는 적절한 부형제와 함께 화학식 1 의 화합물과 조합하여 공지된 제조방법으로 약제학적 조성물을 제조할 수 있다.
약제학적 조성물 및 이의 단위 투여 형태에서 유효성분, 즉 본 발명에 따른 화학식 1 의 단쇄 펩티드의 양은 특정한 응용 방법, 특정한 단쇄 펩티드의 효능 및 바람직한 농도에 따라 폭넓게 다양화 될 수 있거나 조절될 수 있다. 일반적으로 유효 성분의 양은 조성물의 무게에 따라 0.5 % 내지 90 % 범위이다.
이에 맞추어, 본 발명의 단쇄 펩티드를 다음을 포함하지만 이로 인하여 한정되지 않는 골다공증의 다양한 증상 및 장애를 치료하거나 예방하기 위해 동물, 바람직하게 인체에 투여할 수 있다 ;
초기 골다공증, 내분비성 골다공증(endocrine osteoporosis)(갑상선 기능 항진증, 부갑상선 기능 항진증, 쿠싱 증후군, 말단 비대증, 제1형 당뇨병, 부신피질 기능저하증), 유전적이고 선천적인 형태의 골다공증[(골형성 부전증, 호모시스틴뇨증, 멘케스 증후군, 릴리-데이 증후군(Riley-Day syndrome)], 영양 장애 및 위장 장애, 혈액 장애(haematological disorder)/악성 종양(다발성 골수종, 림프종, 백혈병, 혈우병, 탈라세미아), 부동화(immobilization), 만성 폐쇄성 폐질환 또는 류마티스성 질환(rheumatologic disorder)(류마티스 관절염, 척추염) 때문에 발생하는 골다공증, 골 손실을 유발하는 골수염, 뼈에서의 전염성 병변(infectious lesion).
고형 종양 및 혈액학적 악성 종양에 의한 고칼슘혈증, 특발성 고칼슘혈증(idiopathic hypercalcemia) 및 고칼슘혈증은 갑상선 기능 항진증 및 신장 기능 장애와 연관되어 있다. 수술 후의 골 감소증은 스테로이드 투여에 의해서 유도되고, 소장 및 대장의 장애 및 만성 간질환 및 신장 질환과 연관되어 있다. 외상성 손상(traumatic injury) 또는 비외상성 괴사(nontraumatic necrosis)와 연관된 골괴사증 또는 골 세포 사멸은 고셔병(Gaucher's disease), 겸상 적혈구 빈혈, 전신성 홍반성 루푸스 및 그밖의 증상과 연관되어 있다. 치주 골 손실(Periodontal bone loss), 골용해 전이(Osteolytic metastasis), 골절 치료 및 건선과 같은 과잉증식성 피부질환(hyperproliferative skin disorders).
사용된 약자
다음에 기재한 약자를 실시예 및 본원에 인용된 그 외에서 사용하였다 ;
Abu(CN) = 2-아미노-4-시아노부탄산,
Aib = α-아미노-이소부티르산,
Ala= 알라닌,
α-Me-APPA= 2-아미노-2-메틸-5-페닐발레르산,
α-Me-Bip(OMe)= α-메틸화 Bip(OMe),
αMe-Har = 알파-메틸-Har,
αMe-K = 알파-메틸-Lys,
αMe-M = 알파-메틸-Met,
αMe-Nle = 알파-메틸-노르류신,
αMe-Pro= 알파-메틸-프롤린,
α-Me-Phe = 알파-메틸-페닐알라닌,
α-Me-2F-Phe = 알파-메틸-2-플루오로페닐알라닌,
α-Me-2,6-F-Phe = 알파-메틸-2,6-디플루로페닐알라닌,
αMe-R = 알파-메틸-Arg,
αMe-Trp= 알파-메틸-트립토판,
αMe-Val= 알파-메틸-발린,
AC3C= 1-아미노 시클로프로판 카르복실산,
AC5C= 1-아미노-시클로펜탄카르복실산,
AC6C= 1-아미노-시클로헥산카르복실산,
ACN = 아세토니트릴,
APPA = 2-아미노-5-페닐발레르산,
Arg= 아르기닌,
Arg(NO2) = 아르기닌(니트로),
Asp= 아스파르테이트(Aspartate),
Asn= 아스파르긴,
Bn = 벤질,
Boc = tert-부톡시카르보닐,
Bip(OMe)= 2'-에틸-4'-메톡시-비페닐알라닌,
But= O-tert-부틸기,
cAMP= 아데노신 3',5'-사이클릭 모노포스페이트,
Cit = 시트룰린,
DCM = 디클로로메탄,
DMF = N,N-디메틸포름아미드,
DIPCDI= Di-이소프로필카르보디이미드,
DIPEA= 디이소프로필에틸아민,
Et = 에틸,
Et2O = 디에틸 에테르,
EtMet = 에티오닌,
Fmoc = 플루오레닐메톡시카르보닐,
2F-Phe = 2-플루오로페닐알라닌,
g = 그램(s),
Gly= 글리신,
Glu= 글루타메이트,
Gln= 글루타민,
Ile= 이소류신,
h = 시간(시),
His= 히스티딘,
Har = 호모아르기닌(Homoarginine),
HoCit = 호모시트룰린(Homocitrulline),
HoGlu = 호모글루탐산(Homoglutamic acid),
HoLeu = 호모류신(Homoleucine),
HOBt = 1-히드록시벤조트리아졸,
HOAt= 7-아자-히드록시벤조트리아졸(7-Aza-hydroxybenxotriazole),
HBTU = 2-(1H-벤조트리아졸-1-일)-1,1,3,3-테트라메틸 아미늄 헥사플루오로포스페이트,
HPLC = 고성능 액체 크로마토그래피,
K(Biotin) = 리신(비오틴),
K(NO2)= 리신(니트로),
L = 리터,
LC /MS = 액체 크로마토그래피 / 질량분석법,
Lys= 리신,
Me = 메틸,
Met= 메티오닌,
Min = 분(s),
mL = 밀리리터,
ml = 마이크로리터,
mg = 밀리그램(s),
mmol = 밀리몰(millimole)(s),
MS= 질량분석법,
Nva = 노르발린,
Nle = 노르류신,
(NMe)M = N-메틸-Met,
(NMe)Nle = N-메틸-Nle,
(NMe)K = N-메틸-Lys,
(NMe)R = N-메틸-Arg,
(NMe)Har = N-메틸-Har,
Orn = 오르니틴,
Orn(NO2)= 오르니틴(니트로),
po = 경구투여(per-oral administration),
Phe = 페닐알라닌,
PTH = 부갑상선 호르몬,
PTH-1r 작용물질 = 부갑상선 호르몬 수용체 작용물질,
PyBOP = 벤조트리아졸-1-일-옥시-트리스-피롤리디노-포스포늄 헥사플루오로포스페이트,
Pyr = 피로글루탐산(Pyroglutamic acid),
Pro = 프롤린,
sc = 피하경로 투여(Subcutaneous route of administration),
SPPS = 고체상 펩티드 합성(Solid Phase Peptide Synthesis),
SMet= 셀레노메티오닌,
TMS = 트리메틸실릴,
TIPS = 트리이소프로필실란,
TFA = 트리플루오로아세트산,
TBTU= 2-(1H-벤조트리아졸-1-일)-1,1,3,3-테트라메틸아미늄 테트라메틸아미니움 테트라플루오로보레이트,
Trt= 트리틸기(Trityl group),
Trp= 트립토판,
Val= 발린,
WR= 위스타 랫(Wistar Rats).
다음에 기재한 약자를 실시예 및 본원에 인용된 그 외에서 사용하였다 ;
Abu(CN) = 2-아미노-4-시아노부탄산,
Aib = α-아미노-이소부티르산,
Ala= 알라닌,
α-Me-APPA= 2-아미노-2-메틸-5-페닐발레르산,
α-Me-Bip(OMe)= α-메틸화 Bip(OMe),
αMe-Har = 알파-메틸-Har,
αMe-K = 알파-메틸-Lys,
αMe-M = 알파-메틸-Met,
αMe-Nle = 알파-메틸-노르류신,
αMe-Pro= 알파-메틸-프롤린,
α-Me-Phe = 알파-메틸-페닐알라닌,
α-Me-2F-Phe = 알파-메틸-2-플루오로페닐알라닌,
α-Me-2,6-F-Phe = 알파-메틸-2,6-디플루로페닐알라닌,
αMe-R = 알파-메틸-Arg,
αMe-Trp= 알파-메틸-트립토판,
αMe-Val= 알파-메틸-발린,
AC3C= 1-아미노 시클로프로판 카르복실산,
AC5C= 1-아미노-시클로펜탄카르복실산,
AC6C= 1-아미노-시클로헥산카르복실산,
ACN = 아세토니트릴,
APPA = 2-아미노-5-페닐발레르산,
Arg= 아르기닌,
Arg(NO2) = 아르기닌(니트로),
Asp= 아스파르테이트(Aspartate),
Asn= 아스파르긴,
Bn = 벤질,
Boc = tert-부톡시카르보닐,
Bip(OMe)= 2'-에틸-4'-메톡시-비페닐알라닌,
But= O-tert-부틸기,
cAMP= 아데노신 3',5'-사이클릭 모노포스페이트,
Cit = 시트룰린,
DCM = 디클로로메탄,
DMF = N,N-디메틸포름아미드,
DIPCDI= Di-이소프로필카르보디이미드,
DIPEA= 디이소프로필에틸아민,
Et = 에틸,
Et2O = 디에틸 에테르,
EtMet = 에티오닌,
Fmoc = 플루오레닐메톡시카르보닐,
2F-Phe = 2-플루오로페닐알라닌,
g = 그램(s),
Gly= 글리신,
Glu= 글루타메이트,
Gln= 글루타민,
Ile= 이소류신,
h = 시간(시),
His= 히스티딘,
Har = 호모아르기닌(Homoarginine),
HoCit = 호모시트룰린(Homocitrulline),
HoGlu = 호모글루탐산(Homoglutamic acid),
HoLeu = 호모류신(Homoleucine),
HOBt = 1-히드록시벤조트리아졸,
HOAt= 7-아자-히드록시벤조트리아졸(7-Aza-hydroxybenxotriazole),
HBTU = 2-(1H-벤조트리아졸-1-일)-1,1,3,3-테트라메틸 아미늄 헥사플루오로포스페이트,
HPLC = 고성능 액체 크로마토그래피,
K(Biotin) = 리신(비오틴),
K(NO2)= 리신(니트로),
L = 리터,
LC /MS = 액체 크로마토그래피 / 질량분석법,
Lys= 리신,
Me = 메틸,
Met= 메티오닌,
Min = 분(s),
mL = 밀리리터,
ml = 마이크로리터,
mg = 밀리그램(s),
mmol = 밀리몰(millimole)(s),
MS= 질량분석법,
Nva = 노르발린,
Nle = 노르류신,
(NMe)M = N-메틸-Met,
(NMe)Nle = N-메틸-Nle,
(NMe)K = N-메틸-Lys,
(NMe)R = N-메틸-Arg,
(NMe)Har = N-메틸-Har,
Orn = 오르니틴,
Orn(NO2)= 오르니틴(니트로),
po = 경구투여(per-oral administration),
Phe = 페닐알라닌,
PTH = 부갑상선 호르몬,
PTH-1r 작용물질 = 부갑상선 호르몬 수용체 작용물질,
PyBOP = 벤조트리아졸-1-일-옥시-트리스-피롤리디노-포스포늄 헥사플루오로포스페이트,
Pyr = 피로글루탐산(Pyroglutamic acid),
Pro = 프롤린,
sc = 피하경로 투여(Subcutaneous route of administration),
SPPS = 고체상 펩티드 합성(Solid Phase Peptide Synthesis),
SMet= 셀레노메티오닌,
TMS = 트리메틸실릴,
TIPS = 트리이소프로필실란,
TFA = 트리플루오로아세트산,
TBTU= 2-(1H-벤조트리아졸-1-일)-1,1,3,3-테트라메틸아미늄 테트라메틸아미니움 테트라플루오로보레이트,
Trt= 트리틸기(Trityl group),
Trp= 트립토판,
Val= 발린,
WR= 위스타 랫(Wistar Rats).
<110> CADILA HEALTHCARE LIMITED
BAHEKAR, Rajesh H.
JAIN, Mukul R.
PATEL, Pankaj R.
<120> Short-chain peptides as parathyroid hormone (PTH) receptor
<130> MC-99-109
<150> 1095/MUM/2009
<151> 2009-04-24
<150> 225/MUM/2010
<151> 2010-01-28
<160> 955
<170> PatentIn version 3.5
<210> 1
<211> 34
<212> PRT
<213> Homo sapiens
<400> 1
Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn
1 5 10 15
Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His
20 25 30
Asn Phe
<210> 2
<211> 11
<212> PRT
<213> Homo sapiens
<400> 2
Ser Val Ser Glu Ile Gln Leu Met His Asn Leu
1 5 10
<210> 3
<211> 14
<212> PRT
<213> Homo sapiens
<400> 3
Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His
1 5 10
<210> 4
<211> 15
<212> PRT
<213> Homo sapiens
<400> 4
Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu
1 5 10 15
<210> 5
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 5
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 6
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 6
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 7
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 7
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Pro Lys Phe
1 5 10
<210> 8
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 8
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Pro Lys Phe
1 5 10
<210> 9
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 9
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 10
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 10
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 11
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 11
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 12
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 12
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Pro Lys Phe
1 5 10
<210> 13
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 13
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Pro Lys Phe
1 5 10
<210> 14
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 14
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 15
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 15
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 16
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 16
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 17
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 17
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 18
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 18
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Pro Lys Phe
1 5 10
<210> 19
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 19
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Pro Lys Phe
1 5 10
<210> 20
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 20
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 21
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 21
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 22
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclohexane carboxylic
acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 22
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 23
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclohexane carboxylic
acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 23
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 24
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 24
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 25
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 25
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 26
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 26
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 27
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 27
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 28
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 28
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 29
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 29
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 30
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 30
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 31
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 31
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 32
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 32
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 33
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 33
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 34
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 34
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 35
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 35
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 36
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 36
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 37
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 37
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 38
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 38
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 39
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 39
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 40
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 40
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 41
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 41
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 42
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 42
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 43
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 43
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 44
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(114)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 44
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 45
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 45
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 46
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 46
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 47
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 47
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 48
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> Modified residue at this position is 2-amino-4-cyanobutanoic acid
(Abu (CN)), which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 48
Ala Val Ala Glu Ile Gln Phe Met His Arg Arg Ala Lys Phe
1 5 10
<210> 49
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 49
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 50
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 50
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 51
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 51
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 52
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 52
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 53
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 53
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 54
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 54
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 55
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 55
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 56
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 56
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 57
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 57
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 58
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 58
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 59
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 59
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 60
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 60
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 61
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 61
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 62
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 62
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 63
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 63
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 64
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 64
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 65
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 65
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 66
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 66
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 67
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 67
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 68
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 68
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 69
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 69
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 70
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Lysine Biotin (K (Biotin)),
which structurally mimics Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 70
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 71
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 71
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 72
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 72
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 73
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 73
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 74
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 74
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 75
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 75
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 76
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 76
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 77
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 77
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 78
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 78
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 79
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 79
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 80
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 80
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 81
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 81
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 82
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 82
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 83
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 83
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 84
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 84
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 85
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 85
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 86
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> Modified residue at this position is 2-amino-4-cyanobutanoic acid
(Abu (CN)), which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 86
Ala Val Ala Glu Ile Gln Phe Met His Arg Arg Ala Lys Phe
1 5 10
<210> 87
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclohexane carboxylic
acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 87
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 88
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclohexane carboxylic
acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 88
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 89
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclohexane carboxylic
acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 89
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 90
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 90
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 91
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 91
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 92
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 92
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 93
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 93
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 94
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 94
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 95
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 95
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 96
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 96
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 97
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 97
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 98
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 98
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 99
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 99
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 100
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 100
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 101
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 101
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 102
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 102
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 103
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 103
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 104
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 104
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 105
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Lysine Biotin (K (Biotin)),
which structurally mimics Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 105
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 106
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 106
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 107
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 107
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 108
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 108
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 109
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 109
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 110
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 110
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 111
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 111
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 112
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 112
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 113
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 113
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 114
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 114
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 115
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 115
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 116
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 116
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 117
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 117
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 118
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 118
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 119
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 119
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Pro Lys Phe
1 5 10
<210> 120
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclohexane carboxylic
acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 120
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Lys Phe
1 5 10
<210> 121
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 121
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 122
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-methyl-phenylalanine
(alpha-Me-Phe-), which structurally mimics Phenylalanine
<400> 122
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 123
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 123
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 124
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 124
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 125
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 125
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 126
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 126
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 127
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 127
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 128
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 128
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 129
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 129
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 130
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 130
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 131
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 131
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 132
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 132
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 133
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 133
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 134
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 134
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 135
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 135
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 136
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 136
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 137
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 137
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 138
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 138
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 139
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 139
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 140
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 140
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 141
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 141
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 142
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 142
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 143
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 143
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 144
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 144
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 145
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> Modified residue at this position is 2-amino-4-cyanobutanoic acid
(Abu (CN)), which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 145
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 146
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 146
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 147
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 147
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 148
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 148
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 149
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 149
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 150
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 150
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 151
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 151
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 152
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 152
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 153
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -alpha-methyl proline
(alpha-Me-Pro), which structurally mimics Proline
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 153
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 154
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 154
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 155
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 155
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 156
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 156
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 157
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 157
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 158
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 158
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 159
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 159
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 160
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 160
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 161
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 161
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 162
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 162
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 163
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 163
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 164
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 164
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 165
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 165
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 166
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 166
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 167
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 167
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 168
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 168
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 169
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 169
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 170
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 170
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 171
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 171
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 172
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 172
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 173
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 173
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 174
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 174
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 175
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 175
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 176
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 176
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 177
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 177
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 178
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 178
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 179
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 179
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 180
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 180
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 181
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 181
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 182
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 182
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 183
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 183
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 184
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 184
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 185
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 185
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 186
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 186
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 187
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 187
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 188
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 188
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 189
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 189
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 190
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 190
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 191
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 191
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 192
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 192
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 193
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 193
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 194
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 194
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 195
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 195
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 196
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 196
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 197
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 197
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 198
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 198
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 199
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 199
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 200
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 200
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 201
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 201
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 202
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 202
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 203
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 203
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 204
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 204
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 205
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 205
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 206
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 206
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 207
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 207
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 208
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 208
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 209
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 209
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 210
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 210
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 211
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 211
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 212
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 212
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 213
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 213
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 214
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 214
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 215
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 215
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 216
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 216
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 217
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 217
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 218
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 218
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 219
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 219
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 220
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 220
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 221
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 221
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 222
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 222
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 223
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 223
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 224
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 224
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 225
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 225
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 226
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 226
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 227
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 227
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 228
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 228
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 229
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 229
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 230
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 230
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 231
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 231
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 232
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 232
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 233
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 233
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 234
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 234
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 235
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 235
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 236
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 236
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 237
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 237
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 238
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 238
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 239
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 239
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 240
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 240
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 241
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 241
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 242
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 242
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 243
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 243
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 244
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 244
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 245
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 245
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 246
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 246
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 247
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 247
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 248
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 248
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 249
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 249
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 250
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 250
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 251
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 251
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 252
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 252
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 253
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 253
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 254
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 254
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 255
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 255
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 256
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 256
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 257
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 257
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 258
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 258
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 259
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 259
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 260
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 260
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 261
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 261
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 262
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 262
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 263
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 263
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 264
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 264
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 265
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 265
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 266
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 266
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 267
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 267
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 268
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 268
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 269
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 269
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 270
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 270
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 271
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 271
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 272
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 272
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 273
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 273
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 274
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopropane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 274
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 275
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 275
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 276
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 276
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 277
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 277
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 278
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 278
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 279
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 279
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 280
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 280
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 281
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 281
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 282
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 282
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 283
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 283
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 284
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 284
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 285
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 285
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 286
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 286
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 287
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 287
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 288
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 288
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 289
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 289
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 290
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 290
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 291
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 291
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 292
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 292
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 293
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 293
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 294
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 294
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 295
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 295
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 296
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 296
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 297
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 297
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 298
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 298
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 299
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 299
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 300
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 300
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 301
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 301
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 302
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 302
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 303
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 303
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 304
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 304
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 305
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 305
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 306
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 306
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 307
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 307
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 308
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 308
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 309
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 309
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 310
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 310
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 311
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 311
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 312
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 312
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 313
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 313
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 314
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 314
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 315
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 315
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 316
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 316
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 317
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 317
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 318
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 318
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 319
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 319
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 320
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 320
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 321
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 321
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 322
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 322
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 323
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 323
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 324
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 324
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 325
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 325
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 326
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 326
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 327
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 327
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 328
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 328
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 329
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 329
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 330
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 330
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 331
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 331
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 332
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 332
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 333
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 333
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 334
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 334
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 335
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 335
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 336
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 336
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 337
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 337
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 338
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 338
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 339
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 339
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 340
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 340
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 341
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 341
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 342
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 342
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 343
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 343
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 344
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Ornithine (Orn), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 344
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 345
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 345
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 346
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 346
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 347
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 347
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 348
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 348
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 349
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 349
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 350
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 350
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 351
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 351
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 352
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 352
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 353
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 353
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 354
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 354
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 355
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 355
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 356
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 356
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 357
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 357
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 358
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 358
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 359
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 359
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 360
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 360
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 361
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 361
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 362
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 362
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 363
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 363
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 364
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 364
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 365
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 365
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 366
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 366
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 367
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 367
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 368
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 368
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 369
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 369
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 370
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 370
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 371
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 371
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 372
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 372
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 373
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 373
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 374
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 374
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 375
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 375
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 376
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 376
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 377
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 377
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 378
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 378
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 379
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 379
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 380
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 380
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 381
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 381
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 382
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 382
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 383
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 383
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 384
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 384
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 385
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 385
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 386
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 386
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 387
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 387
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 388
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 388
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 389
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 389
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 390
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 390
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 391
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 391
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 392
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 392
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 393
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 393
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 394
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 394
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 395
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 395
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 396
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 396
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 397
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 397
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 398
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 398
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 399
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 399
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 400
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and
prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<400> 400
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 401
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 401
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 402
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 402
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 403
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 403
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 404
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2F-phenylalanine (alpha-Me-2F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 404
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 405
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 405
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 406
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 406
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 407
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 407
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 408
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is Amino cyclopentane
carboxylic acid, which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle), which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit), which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2)) ,
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-F-phenylalanine (alpha-Me-2,6-F-Phe), which
structurally mimics Phenylalanine
<400> 408
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 409
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 409
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 410
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 410
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 411
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 411
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 412
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 412
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 413
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 413
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 414
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 414
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 415
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 415
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 416
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 416
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 417
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 417
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 418
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 418
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 419
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 419
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 420
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 420
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 421
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 421
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 422
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 422
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 423
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 423
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 424
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 424
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 425
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 425
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 426
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 426
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 427
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 427
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 428
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 428
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 429
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 429
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 430
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 430
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 431
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 431
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 432
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 432
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 433
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 433
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 434
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 434
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 435
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 435
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 436
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 436
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 437
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 437
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 438
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 438
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 439
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 439
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 440
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 440
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe
1 5 10
<210> 441
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 441
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 442
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 442
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 443
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 443
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 444
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 444
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 445
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 445
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 446
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 446
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 447
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 447
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 448
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 448
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 449
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 449
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 450
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 450
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 451
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 451
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 452
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 452
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 453
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 453
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 454
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 454
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 455
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 455
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 456
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 456
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe
1 5 10
<210> 457
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 457
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 458
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 458
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 459
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 459
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 460
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 460
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 461
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 461
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 462
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 462
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 463
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 463
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 464
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 464
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 465
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 465
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 466
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 466
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 467
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 467
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 468
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 468
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 469
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 469
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 470
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 470
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 471
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 471
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 472
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 472
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe
1 5 10
<210> 473
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 473
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 474
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 474
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 475
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 475
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 476
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 476
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 477
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 477
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 478
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 478
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 479
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 479
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 480
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 480
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 481
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 481
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 482
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 482
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 483
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 483
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 484
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 484
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 485
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 485
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 486
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 486
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 487
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 487
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 488
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 488
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 489
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 489
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 490
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 490
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 491
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 491
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 492
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 492
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 493
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 493
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 494
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 494
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 495
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 495
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 496
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 496
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 497
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 497
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 498
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 498
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 499
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 499
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 500
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 500
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 501
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 501
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 502
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 502
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 503
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 503
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 504
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 504
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe
1 5 10
<210> 505
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 505
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 506
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 506
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 507
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 507
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 508
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 508
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 509
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 509
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 510
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 510
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 511
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 511
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 512
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 512
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 513
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 513
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 514
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 514
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 515
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 515
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 516
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 516
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 517
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 517
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 518
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 518
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 519
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 519
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 520
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 520
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe
1 5 10
<210> 521
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 521
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 522
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 522
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 523
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 523
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 524
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 524
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 525
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 525
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 526
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 526
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 527
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 527
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 528
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 528
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 529
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 529
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 530
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 530
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 531
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 531
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 532
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 532
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 533
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 533
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 534
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 534
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 535
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 535
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 536
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 536
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe
1 5 10
<210> 537
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 537
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 538
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 538
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 539
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 539
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 540
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 540
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 541
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 541
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 542
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 542
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 543
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 543
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 544
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 544
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 545
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 545
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 546
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 546
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 547
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 547
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 548
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 548
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 549
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 549
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 550
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 550
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 551
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 551
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 552
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 552
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 553
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 553
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 554
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 554
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 555
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 555
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 556
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 556
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 557
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 557
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 558
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 558
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 559
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 559
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 560
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 560
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 561
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 561
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 562
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 562
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 563
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 563
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 564
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 564
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 565
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 565
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 566
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 566
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 567
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 567
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 568
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 568
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Ala Phe
1 5 10
<210> 569
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 569
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 570
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 570
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 571
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 571
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 572
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 572
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 573
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 573
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 574
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 574
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 575
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 575
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 576
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 576
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 577
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 577
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 578
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 578
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 579
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 579
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 580
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 580
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 581
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 581
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 582
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 582
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 583
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 583
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 584
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 584
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Phe Phe
1 5 10
<210> 585
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 585
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 586
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 586
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 587
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 587
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 588
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 588
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 589
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 589
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 590
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 590
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 591
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 591
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 592
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 592
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 593
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 593
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 594
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 594
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 595
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 595
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 596
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 596
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 597
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 597
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 598
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 598
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 599
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 599
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 600
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is arginine (NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 600
Ala Val Ala Glu Ile Gln Phe Met His Gln Ala Ala Arg Phe
1 5 10
<210> 601
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 601
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 602
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 602
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 603
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 603
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 604
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> APPA: Modified residue at this position is
2-Amino-5-phenylpentanoic acid which structurally mimics with
phenylalanine.
<400> 604
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 605
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 605
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 606
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 606
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 607
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> APPA: Modified residue at this position is
2-Amino-5-phenylpentanoic acid which structurally mimics with
phenylalanine.
<400> 607
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 608
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 608
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 609
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 609
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 610
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> APPA: Modified residue at this position is
2-Amino-5-phenylpentanoic acid which structurally mimics with
phenylalanine.
<400> 610
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 611
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 611
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 612
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 612
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 613
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 613
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 614
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 614
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 615
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 615
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 616
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 616
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 617
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 617
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 618
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 618
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 619
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 619
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 620
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 620
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 621
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 621
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 622
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 622
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 623
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 623
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 624
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 624
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 625
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Lysine Biotin which
structurally mimics with Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 625
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 626
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Lysine Biotin which
structurally mimics with Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 626
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 627
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Lysine Biotin which
structurally mimics with Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 627
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 628
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Lysine Biotin which
structurally mimics with Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 628
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 629
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 629
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 630
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 630
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 631
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 631
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 632
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 632
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 633
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 633
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 634
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 634
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 635
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 635
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 636
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 636
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 637
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 637
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 638
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position N-methyl Lysine which
structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 638
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 639
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position N-methyl Lysine which
structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 639
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 640
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 640
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 641
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is N-methyl Norleucine which
structurally mimics with methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 641
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 642
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is N-methyl methionine which
structurally mimics with methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position N-methyl Lysine which
structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 642
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 643
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is N-methyl Norleucine which
structurally mimics with methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position N-methyl Lysine which
structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 643
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 644
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is N-methyl methionine which
structurally mimics with methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position N-methyl Lysine which
structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 644
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 645
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is N-methyl Norleucine which
structurally mimics with methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is homoarginine(NO2) which
structurally mimics with Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position N-methyl Lysine which
structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-Amino-5-phenylpentanoic
acid which structurally mimics with phenylalanine.
<400> 645
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 646
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 646
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 647
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 647
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 648
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 648
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 649
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 649
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 650
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position mimics -alpha amino-isobutyric
acid (Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is -Homo arginine which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is -alpha methyl phenylalanine
which structurally mimics Phenylalanine.
<400> 650
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 651
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-propane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 651
Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Phe
1 5 10
<210> 652
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-propane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 652
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 653
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-propane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 653
Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Phe
1 5 10
<210> 654
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-propane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-propane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 654
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 655
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-propane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-propane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 655
Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Phe
1 5 10
<210> 656
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-propane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 656
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 657
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-propane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 657
Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Phe
1 5 10
<210> 658
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (NO2) which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 658
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 659
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (NO2) which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 659
Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Phe
1 5 10
<210> 660
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (NO2) which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Lysine Biotin which
structurally mimics with Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 660
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 661
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (NO2) which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Lysine Biotin which
structurally mimics with Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 661
Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Phe
1 5 10
<210> 662
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Lysine Biotin which
structurally mimics with Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 662
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 663
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Lysine Biotin which
structurally mimics with Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 663
Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Phe
1 5 10
<210> 664
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine(NO2) which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 664
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 665
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine(NO2) which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 665
Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Phe
1 5 10
<210> 666
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine(NO2) which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 666
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 667
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 667
Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Phe
1 5 10
<210> 668
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine(NO2) which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 668
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 669
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine(NO2) which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 669
Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Phe
1 5 10
<210> 670
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 670
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 671
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is -alpha amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 671
Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Phe
1 5 10
<210> 672
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-propane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 672
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 673
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-propane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
K(CO(CH2)6-CH3) which structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 673
Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Phe
1 5 10
<210> 674
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-propane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine(NO2) which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position N-methyl Lysine which
structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 674
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 675
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This sequence was synthetically synthesisized and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is amino cyclo-pentane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is amino cyclo-propane
carboxylic acid which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is -Norleucine which
structurally mimics Methionine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine(NO2) which
structurally mimics with Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position N-methyl Lysine which
structurally mimics with Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine which structurally mimics
with Phenylalanine.
<400> 675
Ala Val Ala Glu Ile Gln Leu Leu His Gln Arg Ala Lys Phe
1 5 10
<210> 676
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is N-methyl methionine ((NMe)M)
which structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
(K(-CO-(CH2)8-CH3)) which structurally mimics Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine.
<400> 676
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 677
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is N-methyl Norleucine
((NMe)Nle) which structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
(K(-CO-(CH2)8-CH3)) which structurally mimics Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<400> 677
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 678
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is N-methyl methionine ((NMe)M)
which structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Alkylated lysine
(K(-CO-(CH2)8-CH3)) which structurally mimics Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<400> 678
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 679
<211> 14
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is N-methyl Norleucine
((NMe)Nle) which structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Alkylated lysine
(K(-CO-(CH2)8-CH3)) which structurally mimics Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<400> 679
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe
1 5 10
<210> 680
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 680
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 681
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 681
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 682
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(13)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 682
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 683
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 683
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 684
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 684
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 685
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 685
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 686
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is N-methyl methionine ((NMe)M)
which structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
(K(-CO-(CH2)8-CH3)) which structurally mimics Lysine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine.
<400> 686
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 687
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is N-methyl Norleucine
((NMe)Nle) which structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alkylated lysine
(K(-CO-(CH2)8-CH3)) which structurally mimics Lysine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<400> 687
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 688
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 688
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 689
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 689
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 690
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 690
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 691
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 691
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 692
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(13)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 692
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 693
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine ( -Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 693
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 694
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 694
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 695
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine ( -Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 695
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 696
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino isobutyric acid
(Aib), which structurally mimics alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine ( -Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 696
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 697
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 697
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 698
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine ( -Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 698
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 699
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha -Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 699
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 700
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine.
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha -Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 700
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 701
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 701
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 702
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 702
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 703
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 703
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 704
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 704
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 705
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 705
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 706
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 706
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 707
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 707
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 708
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 708
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 709
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 709
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 710
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 710
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 711
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 711
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 712
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 712
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 713
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 713
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 714
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 714
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 715
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 715
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 716
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 716
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 717
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 717
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 718
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 718
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 719
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 719
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 720
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 720
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 721
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 721
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 722
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 722
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 723
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 723
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 724
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 724
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 725
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 725
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 726
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 726
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 727
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 727
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 728
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 728
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 729
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Arginine(Nitro) (Arg(NO2))
which structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 729
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 730
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 730
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 731
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 731
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 732
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 732
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 733
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 733
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 734
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 734
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 735
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 735
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 736
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 736
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 737
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 737
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 738
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 738
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 739
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 739
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 740
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 740
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 741
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 741
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 742
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 742
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 743
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 743
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 744
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 744
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 745
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 745
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 746
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 746
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 747
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 747
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 748
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 748
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 749
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 749
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 750
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 750
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 751
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 751
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 752
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 752
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 753
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 753
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 754
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 754
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 755
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 755
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 756
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 756
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 757
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 757
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 758
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 758
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 759
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 759
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 760
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 760
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 761
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 761
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 762
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 762
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 763
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 763
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 764
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 764
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 765
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 765
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 766
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 766
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 767
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 767
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 768
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 768
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 769
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 769
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 770
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 770
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 771
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 771
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 772
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 772
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 773
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 773
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 774
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 774
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 775
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 775
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 776
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 776
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 777
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 777
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 778
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 778
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 779
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 779
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 780
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 780
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 781
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 781
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 782
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 782
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 783
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 783
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 784
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 784
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 785
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 785
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 786
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 786
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 787
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 787
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 788
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 788
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 789
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 789
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 790
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 790
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 791
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 791
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 792
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 792
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 793
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 793
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 794
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 794
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 795
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 795
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 796
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 796
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 797
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine.
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 797
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 798
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 798
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Ala Phe Phe
1 5 10 15
<210> 799
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 799
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Ala Phe Phe
1 5 10 15
<210> 800
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 800
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Phe Phe Phe
1 5 10 15
<210> 801
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 801
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Phe Phe Phe
1 5 10 15
<210> 802
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 802
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 803
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 803
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 804
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 804
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 805
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 805
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 806
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 806
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Ala Phe Phe
1 5 10 15
<210> 807
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 807
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Ala Phe Phe
1 5 10 15
<210> 808
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 808
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Phe Phe Phe
1 5 10 15
<210> 809
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 809
Ala Val Ala Glu Ile Gln Leu Met His Gln Phe Ala Phe Phe Phe
1 5 10 15
<210> 810
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 810
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 811
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 811
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 812
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 812
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 813
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 813
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 814
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 814
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 815
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 815
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 816
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 816
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 817
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 817
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 818
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 818
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 819
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 819
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 820
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 820
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 821
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 821
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 822
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 822
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 823
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 823
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 824
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 824
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 825
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 825
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 826
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 826
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 827
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 827
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 828
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 828
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 829
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 829
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 830
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 830
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 831
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 831
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 832
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 832
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 833
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 833
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 834
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 834
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 835
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 835
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 836
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 836
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 837
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 837
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 838
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 838
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 839
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 839
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 840
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 840
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 841
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Orn which structurally
mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 841
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 842
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 842
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 843
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 843
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 844
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 844
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 845
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 845
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 846
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 846
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 847
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 847
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 848
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 848
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 849
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 849
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 850
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 850
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 851
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 851
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 852
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 852
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 853
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 853
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 854
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 854
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 855
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 855
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 856
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 856
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 857
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 857
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 858
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 858
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 859
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 859
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 860
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 860
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 861
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 861
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 862
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 862
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 863
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 863
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 864
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 864
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 865
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 865
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 866
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 866
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 867
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 867
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 868
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 868
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 869
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 869
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 870
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 870
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 871
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 871
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Ala Phe Phe
1 5 10 15
<210> 872
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 872
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 873
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is HomoCitrulline (HoCit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 873
Ala Val Ala Glu Ile Gln Phe Met His Gln Arg Ala Phe Phe Phe
1 5 10 15
<210> 874
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 874
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 875
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 875
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 876
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 876
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 877
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 877
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 878
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 878
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe Phe
1 5 10 15
<210> 879
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 879
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe Phe
1 5 10 15
<210> 880
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 880
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe Phe
1 5 10 15
<210> 881
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 881
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe Phe
1 5 10 15
<210> 882
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 882
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 883
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 883
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 884
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 884
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 885
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Citrulline (Cit) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 885
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Arg Phe Phe
1 5 10 15
<210> 886
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 886
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe Phe
1 5 10 15
<210> 887
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 887
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Ala Phe Phe
1 5 10 15
<210> 888
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 888
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe Phe
1 5 10 15
<210> 889
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (7)..(7)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 889
Ala Val Ala Glu Ile Gln Phe Met His Gln Phe Ala Phe Phe Phe
1 5 10 15
<210> 890
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 890
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Ala Phe
1 5 10 15
<210> 891
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 891
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Ala Phe
1 5 10 15
<210> 892
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 892
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 893
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 893
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 894
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-Me-V which
structurally mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 894
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 895
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-Me-V which
structurally mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 895
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 896
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is NMe-V which structurally
mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 896
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 897
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is NMe-V which structurally
mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 897
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Phe Phe
1 5 10 15
<210> 898
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 898
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Ala Phe
1 5 10 15
<210> 899
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 899
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Ala Phe
1 5 10 15
<210> 900
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 900
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 901
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 901
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 902
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 902
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Ala Phe
1 5 10 15
<210> 903
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 903
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Ala Phe
1 5 10 15
<210> 904
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 904
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 905
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 905
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 906
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-Me-V which
structurally mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 906
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 907
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-Me-V which
structurally mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 907
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 908
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is NMe-V which structurally
mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 908
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 909
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is NMe-V which structurally
mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is Norleucine (Nle) which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 909
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 910
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-Me-V which
structurally mimics Valine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 910
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Ala Phe
1 5 10 15
<210> 911
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 911
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Ala Phe
1 5 10 15
<210> 912
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 912
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 913
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 913
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 914
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 914
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Ala Phe
1 5 10 15
<210> 915
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 915
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Ala Phe
1 5 10 15
<210> 916
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-V which
structurally mimics Valine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 916
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Ala Phe
1 5 10 15
<210> 917
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 917
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Ala Phe
1 5 10 15
<210> 918
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Bip(OMe) which
structurally mimics Phenyl alanine.
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 918
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Ala Phe
1 5 10 15
<210> 919
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 919
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Ala Phe
1 5 10 15
<210> 920
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 920
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 921
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 921
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 922
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 922
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 923
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 923
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 924
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 924
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 925
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 925
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 926
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-Me-V which
structurally mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 926
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 927
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-Me-V which
structurally mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 927
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 928
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is NMe-V which structurally
mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 928
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 929
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is NMe-V which structurally
mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
2'-Ethyl-4'-methoxy-biphenylalanine (Bip(OMe)) which structurally
mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 929
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 930
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 930
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 931
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 931
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 932
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 932
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 933
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 933
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 934
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 934
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 935
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 935
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 936
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 936
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 937
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 937
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 938
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-Me-V which
structurally mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 938
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 939
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-Me-V which
structurally mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 939
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 940
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is NMe-V which structurally
mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 940
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 941
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is NMe-V which structurally
mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is
alpha-methyl-2,6-diflurophenylalanine (alpha-Me-2,6F-Phe) which
structurally mimics Phenyl alanine
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 941
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Phe Phe
1 5 10 15
<210> 942
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 942
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
<210> 943
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 943
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
<210> 944
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 944
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
<210> 945
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 945
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
<210> 946
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 946
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
<210> 947
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 947
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
<210> 948
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 948
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
<210> 949
<211> 15
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (3)..(3)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (8)..(8)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (13)..(13)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is 2-amino-5-phenylpentanoic
acid (APPA) which structurally mimics Phenyl alanine
<400> 949
Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
<210> 950
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 950
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
<210> 951
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is 1-amino cyclopropane
carboxylic acid (AC3C) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 951
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
<210> 952
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 952
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
<210> 953
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 953
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
<210> 954
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-Me-V which
structurally mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-Me-M which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 954
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
<210> 955
<211> 16
<212> PRT
<213> Artificial
<220>
<223> This short-chain peptide was synthetically generated and prepared
<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> Modified residue at this position is alpha-Me-V which
structurally mimics Valine
<220>
<221> MISC_FEATURE
<222> (2)..(2)
<223> Modified residue at this position is
1-amino-cyclopentanecarboxylic acid (AC5C) which structurally
mimics Alanine
<220>
<221> MISC_FEATURE
<222> (4)..(4)
<223> Modified residue at this position is alpha-amino-isobutyric acid
(Aib) which structurally mimics Alanine
<220>
<221> MISC_FEATURE
<222> (9)..(9)
<223> Modified residue at this position is alpha-MeNle which
structurally mimics Methionine
<220>
<221> MISC_FEATURE
<222> (12)..(12)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (14)..(14)
<223> Modified residue at this position is Homoarginine (Har) which
structurally mimics Arginine
<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> Modified residue at this position is alpha-Me-Trp mimics Trp
<220>
<221> MISC_FEATURE
<222> (16)..(16)
<223> Modified residue at this position is alpha-Me-APPA which
structurally mimics Phenyl alanine
<400> 955
Val Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Arg Trp Phe
1 5 10 15
Claims (22)
- 다음의 화학식 1 의 서열을 갖는 분리된 단쇄 펩티드의 호변이성체(tautomer) 및 용매 화합물을 포함하는, 다음의 화학식 1 의 서열을 갖는 분리된 단쇄 펩티드
화학식 1
A-Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10-Z11-Z12-Z13-Z14-Z15-B
여기에서
A는 -NH-R1 또는 R3-CO-NH-기를 나타내고
여기에서
R1 은 수소, 비오틴, 임의로 치환된 선형 또는 가지형 (C1 -18) 알킬 사슬, 또는 피로글루탐산(Pyr), Pro(P), 알파-메틸-프롤린(αMe-P), Val(V), N-메틸-발린(NMe-V), 알파-메틸-발린(αMe-V), Lys(비오틴), Lys(알킬), Lys(아세틸)과 같은 적절한 아미노산을 나타내고 ;
R3 은 각각의 기들이 적절한 치환기로 추가로 치환될 수 있는 선형 또는 가지형(C1-18) 알킬 사슬, (C1-6)알콕시, (C3-C6)시클로알킬, 아릴, 헤테로아릴 또는 아릴알킬기 중에서 선택한 것이고 :
B는 -COOR2, -CONHR2 또는 CH2OR2 을 나타내고,
여기에서
R2 는 H 또는 Val(V), 알파-메틸-발린(αMe-V), Lys(비오틴), Lys(알킬) 및 Lys(아세틸) 중에서 선택한 적절한 아미노산을 나타내고 :
각각의 Z1, Z3 및 Z12 는 동일하거나 상이할 수 있으며, 독립적으로 Ser(S), 알파-메틸-세린(αMe-S), Val(V), 알파-메틸-발린(αMe-V), Pro(P), 알파-메틸-프롤린(αMe-P), Gly(G), Ala(A), α-아미노-이소부티르산(Aib), 1-아미노 시클로프로판 카르복실산(AC3C), 1-아미노-시클로펜탄카르복실산(AC5C), 1-아미노-시클로헥산카르복실산(AC6C)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않은 아미노산을 나타내고 :
Z2는 Val(V) 또는 αMe-Val(αMe-V)을 나타내고 :
각각의 Z4, Z6 및 Z10은 동일하거나 상이할 수 있으며, 독립적으로 Glu(E), 호모글루탐산(Homoglutamic acid : HoGlu), 2-아미노-4-시아노부탄산(Abu(CN)), Asp(D), Asn(N), Gln(Q), Aib 을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고,
각각의 Z5, Z7 및 Z9 은 동일하거나 상이할 수 있으며, 독립적으로 Leu(L), Ile(I), Nle(노르류신), Nva(노르발린), HoLeu(호모류신: Homoleucine), Abu(CN), His(H), Phe(F), 알파-메틸-페닐알라닌(-α-Me-Phe-), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-) 또는 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-) 또는 2-플루오로페닐알라닌(-2F-Phe-)기를 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ;
Z8 은 Met, N-메틸-Met((NMe)M), 알파-메틸-Met(αMe-M), 알파-메틸-발린(αMe-V), Leu, Nle, N-메틸-Nle((NMe)Nle), 알파-메틸-노르류신(αMe-Nle), Nva, HoLeu, 에티오닌(EtMet), 셀레노메티오닌(SMet), Val 을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ;
Z11 및 Z13 은 동일하거나 상이할 수 있으며, 독립적으로 Aib, Pro(P), αMe-Pro, 리신(K), 리신-비오틴(K(비오틴)), 리신(니트로)[K(NO2)], 아르기닌(R), 아르기닌(니트로)[(Arg(NO2)], 호모아르기닌(Homoarginine : Har), 오르니틴(Orn), 오르니틴(니트로)[Orn(NO2)], 시트룰린(Cit), 호모시트룰린(Homocitrulline : HoCit), Phe(F), 알파-메틸-페닐알라닌(-α-Me-Phe-), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-) 또는 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-) 또는 2-플루오로페닐알라닌(-2F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ;
Z14 는 2'-에틸-4'-메톡시-비페닐알라닌(Bip(OMe)), α-메틸화 Bip(OMe)[αMe-Bip(OMe)], αMe-Trp, 알파-메틸-페닐알라닌(-α-Me-Phe-), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-), 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-) 또는 2-플루오로페닐알라닌(-2F-Phe-)기를 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내며 ;
Z15 는 존재하거나 존재하지 않으며, 존재할 때 Z15 는 2-아미노-5-페닐발레르산(APPA) 또는 2-아미노-2-메틸-5-페닐발레르산(α-Me-APPA)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타낸다. - 제 1 항에 있어서, A는 -NH-R1 또는 R3-CO-NH-기를 나타내고, R1은 수소, 비오틴 또는 피로글루탐산(Pyr), Pro(P) 및 Val(V) 중에서 선택한 적절한 아미노산을 나타냄을 특징으로 하는 화합물.
- 제 1 항에 있어서, R3은 추가적으로 치환된 선형 또는 가지형(C1-18) 알킬 사슬 중에서 선택한 것임을 특징으로 하는 화합물.
- 제 1 항에 있어서, B는 -COOR2, -CONHR2를 나타내며, R2는 H 또는 Val(V), 알파-메틸-발린(αMe-V) 또는 Lys(비오틴) 중에서 선택한 적절한 아미노산을 나타냄을 특징으로 하는 화합물.
- 제 1 항에 있어서, 각각의 Z1, Z3 및 Z12 은 동일하거나 상이할 수 있으며, 독립적으로 Ala(A), α-아미노-이소부티르산(Aib), 1-아미노 시클로프로판 카르복실산(AC3C), 1-아미노-시클로펜탄카르복실산(AC5C), 1-아미노-시클로헥산카르복실산(AC6C)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타냄을 특징으로 하는 화합물.
- 제 1 항에 있어서, Z2 는 Val(V)를 나타냄을 특징으로 하는 화합물.
- 제 1 항에 있어서, 각각의 Z4, Z6 및 Z10 은 동일하거나 상이할 수 있으며, 독립적으로 Glu(E), Gln(Q) 또는 Aib 를 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타냄을 특징으로 하는 화합물.
- 제 1 항에 있어서, 각각의 Z5, Z7 및 Z9 은 동일하거나 상이할 수 있으며, 독립적으로 Leu(L), Ile(I), Nle, HoLeu(호모류신), His(H), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-) 또는 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타냄을 특징으로 하는 화합물.
- 화학식 1 에서 Z8 은 Met, 알파-메틸-Met(αMe-M), Nle, N-메틸-Nle((NMe)Nle)를 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내는 화학식 1 의 화합물.
- 제 1 항에 있어서, 각각의 Z11 및 Z13 은 동일하거나 상이할 수 있으며, 독립적으로 Aib, αMe-Pro, 리신(K), 리신-비오틴(K(비오틴)), K(NO2), 아르기닌(R), Arg(NO2), 호모아르기닌(Har), 오르니틴(Orn), Orn(NO2), 시트룰린(Cit), 호모시트룰린(HoCit), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-) 또는 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타냄을 특징으로 하는 화합물.
- 제 1 항에 있어서, Z14는 2'-에틸-4'-메톡시-비페닐알라닌(Bip(OMe)), α-메틸화 Bip(OMe)[αMe-Bip(OMe)], 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-) 또는 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타냄을 특징으로 하는 화합물.
- 제 1 항에 있어서, Z15는 2-아미노-5-페닐발레르산(APPA) 또는 2-아미노-2-메틸-5-페닐발레르산(α-Me-APPA)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타냄을 특징으로 하는 화합물.
- 제 1 항에 있어서, 아릴기는 페닐, 나프틸, 인다닐, 플루오레닐 또는 비페닐기 중에서 선택한 것임을 특징으로 하는 화합물.
- 제 1 항에 있어서, 헤테로아릴기는 피리딜, 티에닐, 푸릴, 이미다졸릴, 벤조푸라닐기 중에서 선택한 것임을 특징으로 하는 화합물.
- 제 1 항에 있어서, 치환기가 존재할 때, 치환기는 히드록실, 옥소, 할로, 티오(thio), 니트로, 아미노, 알킬, 알콕시, 할로알킬 또는 할로알콕시기 중에서 선택한 것임을 특징으로 하는 화합물.
- 제 1 항에 있어서, 다음 화학식 1 의 화합물
화학식 1
A-Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10-Z11-Z12-Z13-Z14-Z15-B
여기에서
A 는 -NH-R1 또는 R3-CO-NH- 기를 나타내고,
여기에서,
R1 은 수소, 비오틴 또는 피로글루탐산(Pyr), Pro(P), Val(V) 중에서 선택한 적절한 아미노산을 나타내고,
R3 은 임의로 치환된 선형 또는 가지형 (C1-18) 알킬 사슬 중에서 선택한 것이고,
B 는 -COOR2, -CONHR2 를 나타내고
여기에서, R2 는 제 1 항에 나타낸 바와 같고,
각각의 Z1, Z3 및 Z12 는 동일하거나 상이할 수 있으며, 독립적으로 Ala(A), α-아미노-이소부티르산(Aib), 1-아미노 시클로프로판 카르복실산(AC3C), 1-아미노-시클로펜탄카르복실산(AC5C), 1-아미노-시클로헥산카르복실산(AC6C)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ;
Z2 는 Val(V)를 나타내고 ;
각각의 Z4 , Z6 및 Z10 는 동일하거나 상이할 수 있으며, 독립적으로 Glu(E), Gln(Q), Aib를 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ;
Z5, Z7 및 Z9 는 동일하거나 상이할 수 있으며, 독립적으로 Leu(L), Ile(I), Nle, HoLeu(호모류신), His(H), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-), 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ;
Z8은 Met, 알파-메틸-Met(αMe-M), Nle, N-메틸-Nle((NMe)Nle)를 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ;
Z11 및 Z13 는 동일하거나 상이할 수 있으며, 독립적으로 Aib, αMe-Pro, 리신(K), 리신-비오틴(K(비오틴)), K(NO2), 아르기닌(R), Arg(NO2), 호모아르기닌(Har), 오르니틴(Orn), Orn(NO2), 시트룰린(Cit), 호모시트룰린(HoCit), 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-), 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내고 ;
Z14는 2'-에틸-4'-메톡시-비페닐알라닌(Bip(OMe)), α-메틸화 Bip(OMe)[αMe-Bip(OMe)], 알파-메틸-2-플루오로페닐알라닌(-α-Me-2F-Phe-), 알파-메틸-2,6-디플루로페닐알라닌(-α-Me-2,6-F-Phe-)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타내며 ;
Z15는 존재할 때 2-아미노-5-페닐발레르산(APPA) 또는 2-아미노-2-메틸-5-페닐발레르산(α-Me-APPA)을 포함하는 기 중에서 선택한 자연적으로 발생하는 아미노산 또는 자연적으로 발생하지 않는 아미노산을 나타낸다. - 다음 중에서 선택한 화학식 Ⅰ의 화합물 ;
Aib-V-Aib-EIQLMHQ-Har-AK-(α-Me-Phe);
Aib-V-Aib-EIQL-Nle-HQ-Har-AK-(α-Me-Phe);
Aib-V-Aib-EIQLMHQ-Har-(αMe-Pro)-K-(α-Me-Phe);
Aib-V-Aib-EIQL-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-Phe);
Aib-V-Aib-EIQLMHQ-Har-Aib-K-(α-Me-Phe);
Aib-V-Aib-EIQL-Nle-HQ-Har-Aib-K-(α-Me-Phe);
(AC3C)-V-Aib-EIQL-Nle-HQ-Har-AK-(α-Me-Phe);
(AC3C)-V-Aib-EIQLMHQ-Har-(αMe-Pro)-K-(α-Me-Phe);
(AC3C)-V-Aib-EIQL-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-Phe);
(AC3C)-V-Aib-EIQLMHQ-Har-Aib-K-(α-Me-Phe);
(AC3C)-V-Aib-EIQL-Nle-HQ-Har-Aib-K-(α-Me-Phe);
Aib-V-(AC5C)-EIQLMHQ-Har-Aib-K-(α-Me-Phe);
Aib-V-(AC5C)-EIQL-Nle-HQ-Har-Aib-K-(α-Me-Phe);
(AC5C)-V-(AC5C)-EIQLMHQ-Har-(αMe-Pro)-K-(α-Me-Phe);
(AC5C)-V-(AC5C)-EIQL-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-Phe);
(AC5C)-V-Aib-EIQLMHQ-Har-Aib-K-(α-Me-Phe);
(AC5C)-V-Aib-EIQL-Nle-HQ-Har-Aib-K-(α-Me-Phe);
Aib-V-(AC6C)-EIQLMHQ-Har-Aib-K-(α-Me-Phe);
Aib-V-(AC6C)-EIQL-Nle-HQ-Har-Aib-K-(α-Me-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-H-(Abu(CN))-Har-AK-(α-Me-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-M-HQ-Har-AK-(α-Me-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-M-HQ-Har-(αMe-Pro)-K-(α-Me-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-M-HQ-Har-Aib-K-(α-Me-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-K(비오틴)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-H-(Abu(CN))-Har-AK-(α-Me-2F-Phe);
Aib-V-(AC6C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-2F-Phe);
Aib-V-(AC6C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2F-Phe);
Aib-V-(AC6C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-AK-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-K(비오틴)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AK-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-(αMe-Pro)-K-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-K-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-(AC5C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Orn-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Cit-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(HoCit)-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-Cit-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-Cit-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-Cit-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-Cit-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-Aib-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-Aib-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-Aib-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-Aib-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-(α-Me-2,6-F-Phe)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe) ;
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-(α-Me-2,6-F-Phe)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-Arg(NO2)-(α-Me-2F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-Arg(NO2)-(α-Me-2F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-Arg(NO2)-(α-Me-2,6-F-Phe)
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Aib-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-A-Arg(NO2)-(α-Me-2,6-F-Phe);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Aib-Aib-Arg(NO2)-(α-Me-2,6-F-Phe);
Aib-V-Aib-EIQLMHQ-Har-AK-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-AK-(Bip(OMe))-(APPA);
(AC3C)-V-Aib-EIQLMHQ-Har-AK-(Bip(OMe))-(APPA);
(AC3C)-V-Aib-EIQL-Nle-HQ-Har-AK-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQLMHQ-Har-AK-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Har-AK-(Bip(OMe))-(APPA);
Aib-V-(AC3C)-EIQLMHQ-Har-AK-(Bip(OMe))-(APPA);
Aib-V-(AC3C)-EIQL-Nle-HQ-Har-AK-(Bip(OMe))-(APPA);
(AC3C)-V-(AC3C)-EIQLMHQ-Har-AK-(Bip(OMe))-(APPA);
(AC3C)-V-(AC3C)-EIQL-Nle-HQ-Har-AK-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQLMHQ-Har-AK-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQL-Nle-HQ-Har-AK-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQLMHQ-Har(NO2)-AK-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har(NO2)-AK-(Bip(OMe))-(APPA);
(AC3C)-V-Aib-EIQLMHQ-Har(NO2)-AK-(Bip(OMe))-(APPA);
(AC3C)-V-Aib-EIQL-Nle-HQ-Har(NO2)-AK-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQLMHQ-Har(NO2)-AK-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Har(NO2)-AK-(Bip(OMe))-(APPA);
Aib-V-(AC3C)-EIQLMHQ-Har(NO2)-AK-(Bip(OMe))-(APPA);
Aib-V-(AC3C)-EIQL-Nle-HQ-Har(NO2)-AK-(Bip(OMe))-(APPA);
(AC3C)-V-(AC3C)-EIQLMHQ-Har(NO2)-AK-(Bip(OMe))-(APPA);
(AC3C)-V-(AC3C)-EIQL-Nle-HQ-Har(NO2)-AK-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQLMHQ-Har(NO2)-AK-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQL-Nle-HQ-Har(NO2)-AK-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQLMHQ-Har(NO2)-A-K(비오틴)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har(NO2)-A-K(비오틴)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQLMHQ-Har-A-K(비오틴)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-A-K(비오틴)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQLMHQ-Har(NO2)-A-K(-CO-(CH2)6-CH3)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har(NO2)-A-K(-CO-(CH2)6-CH3)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQLMHQ-Har-A-K(-CO-(CH2)6-CH3)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-A-K(-CO-(CH2)6-CH3)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQLMHQ-Har(NO2)-A-K(-CO-(CH2)8-CH3)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har(NO2)-A-K(-CO-(CH2)8-CH3)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQLMHQ-Har-A-K(-CO-(CH2)8-CH3)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-A-K(-CO-(CH2)8-CH3)-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQL-Nle-HQ-Har-A-K(-CO-(CH2)8-CH3)-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQLMHQ-Har(NO2)-A-(NMe)K-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQL-Nle-HQ-Har(NO2)-A-(NMe)K-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQL-(NMe)M-HQ-Har-A-K(-CO-(CH2)8-CH3)-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQL-(NMe)Nle-HQ-Har-A-K(-CO-(CH2)8-CH3)-(Bip(OMe))-(APPA);
(AC3C)-V-(AC3C)-EIQL-(NMe)M-HQ-Har(NO2)-A-(NMe)K-(Bip(OMe))-(APPA);
(AC3C)-V-(AC3C)-EIQL-(NMe)Nle-HQ-Har(NO2)-A-(NMe)K-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQL-(NMe)M-HQ-Har(NO2)-A-(NMe)K-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQL-(NMe)Nle-HQ-Har(NO2)-A-(NMe)K-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQLMHQ-Har-AK-(Bip(OMe));
Aib-V-Aib-EIQL-Nle-HQ-Har-AK-(Bip(OMe));
(AC3C)-V-Aib-EIQLMHQ-Har-AK-(Bip(OMe));
(AC3C)-V-Aib-EIQL-Nle-HQ-Har-AK-(Bip(OMe));
(AC5C)-V-Aib-EIQLMHQ-Har-AK-(Bip(OMe));
(AC5C)-V-Aib-EIQL-Nle-HQ-Har-AK-(Bip(OMe));
Aib-V-(AC3C)-EIQLMHQ-Har-AK-(Bip(OMe));
Aib-V-(AC3C)-EIQL-Nle-HQ-Har-AK-(Bip(OMe));
(AC3C)-V-(AC3C)-EIQLMHQ-Har-AK-(Bip(OMe));
(AC3C)-V-(AC3C)-EIQL-Nle-HQ-Har-AK-(Bip(OMe));
(AC5C)-V-(AC3C)-EIQLMHQ-Har-AK-(Bip(OMe));
(AC5C)-V-(AC3C)-EIQL-Nle-HQ-Har-AK-(Bip(OMe));
Aib-V-Aib-EIQLMHQ-Har(NO2)-AK-(Bip(OMe));
Aib-V-Aib-EIQL-Nle-HQ-Har(NO2)-AK-(Bip(OMe));
Aib-V-Aib-EIQLMHQ-Har(NO2)-A-K(비오틴)-(Bip(OMe));
Aib-V-Aib-EIQL-Nle-HQ-Har(NO2)-A-K(비오틴)-(Bip(OMe));
Aib-V-Aib-EIQLMHQ-Har-A-K(비오틴)-(Bip(OMe));
Aib-V-Aib-EIQL-Nle-HQ-Har-A-K(비오틴)-(Bip(OMe));
Aib-V-Aib-EIQLMHQ-Har(NO2)-A-K(-CO-(CH2)6-CH3)-(Bip(OMe));
Aib-V-Aib-EIQL-Nle-HQ-Har(NO2)-A-K(-CO-(CH2)6-CH3)-(Bip(OMe));
Aib-V-Aib-EIQLMHQ-Har-A-K(-CO-(CH2)6-CH3)-(Bip(OMe));
Aib-V-Aib-EIQL-Nle-HQ-Har-A-K(-CO-(CH2)6-CH3)-(Bip(OMe));
Aib-V-Aib-EIQLMHQ-Har(NO2)-A-K(-CO-(CH2)8-CH3)-(Bip(OMe));
Aib-V-Aib-EIQL-Nle-HQ-Har(NO2)-A-K(-CO-(CH2)8-CH3)-(Bip(OMe));
Aib-V-Aib-EIQLMHQ-Har-A-K(-CO-(CH2)8-CH3)-(Bip(OMe));
Aib-V-Aib-EIQL-Nle-HQ-Har-A-K(-CO-(CH2)8-CH3)-(Bip(OMe));
(AC5C)-V-(AC3C)-EIQLMHQ-Har-A-K(-CO-(CH2)8-CH3)-(Bip(OMe));
(AC5C)-V-(AC3C)-EIQL-Nle-HQ-Har-A-K(-CO-(CH2)8-CH3)-(Bip(OMe));
(AC5C)-V-(AC3C)-EIQLMHQ-Har(NO2)-A-(NMe)K-(Bip(OMe));
(AC5C)-V-(AC3C)-EIQL-Nle-HQ-Har(NO2)-A-(NMe)K-(Bip(OMe));
Aib-V-Aib-EIQL-(NMe)M-HQ-Har-A-K(-CO-(CH2)8-CH3)-(Bip(OMe));
Aib-V-Aib-EIQL-(NMe)Nle-HQ-Har-A-K(-CO-(CH2)8-CH3)-(Bip(OMe));
(AC3C)-V-Aib-EIQL-(NMe)M-HQ-Har-A-K(-CO-(CH2)8-CH3)-(Bip(OMe));
(AC3C)-V-Aib-EIQL-(NMe)Nle-HQ-Har-A-K(-CO-(CH2)8-CH3)-(Bip(OMe));
Aib-V-Aib-EIQLMHQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC3C)-V-Aib-EIQLMHQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC3C)-V-Aib-EIQL-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQLMHQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQLMHQ-Har-Aib-Arg(NO2)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
Aib-V-(AC3C)-EIQLMHQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
Aib-V-(AC3C)-EIQL-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC3C)-V-(AC3C)-EIQLMHQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC3C)-V-(AC3C)-EIQL-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQLMHQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQL-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
Aib-V-(AC3C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC3C)-V-(AC3C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
Aib-V-(AC3C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC3C)-V-(AC3C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
(AC5C)-V-(AC3C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe)-(APPA);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe)-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe)-(APPA);
Aib-V-(AC3C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe)-(APPA);
(AC3C)-V-(AC3C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe)-(APPA);
(AC5C)-V-(AC3C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe)-(APPA);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe)-(APPA);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe)-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe)-(APPA);
Aib-V-(AC3C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe)-(APPA);
(AC3C)-V-(AC3C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe)-(APPA);
(AC5C)-V-(AC3C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2,6-F-Phe)-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe)-(APPA);
(AC3C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe)-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe)-(APPA);
Aib-V-(AC3C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe)-(APPA);
(AC3C)-V-(AC3C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe)-(APPA);
(AC5C)-V-(AC3C)-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe)-(APPA);
Aib-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe)-(APPA);
(AC3C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe)-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe)-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-Aib-Arg(NO2)-(α-Me-2F-Phe)-(APPA);
Aib-V-(AC3C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe)-(APPA);
(AC3C)-V-(AC3C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe)-(APPA);
(AC5C)-V-(AC3C)-EIQ-(α-Me-2F-Phe)-Nle-HQ-Har-A-Arg(NO2)-(α-Me-2F-Phe)-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-AR-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Har-AR-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-A-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Har-A-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-A-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Har-A-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-Aib-R-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Har-Aib-R-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-Aib-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Har-Aib-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-Aib-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Har-Aib-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Orn-AR-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Orn-AR-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Orn-A-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Orn-A-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Orn-A-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Orn-A-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Orn-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Orn-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Orn-Aib-R-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Orn-Aib-R-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Orn-Aib-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Orn-Aib-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Orn-Aib-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Orn-Aib-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Orn-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Orn-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Cit-AR-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Cit-AR-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Cit-A-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Cit-A-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Cit-A-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Cit-A-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Cit-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Cit-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Cit-Aib-R-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Cit-Aib-R-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Cit-Aib-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Cit-Aib-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Cit-Aib-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Cit-Aib-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Cit-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-Cit-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(HoCit)-AR-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(HoCit)-AR-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(HoCit)-A-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(HoCit)-A-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(HoCit)-A-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(HoCit)-A-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(HoCit)-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(HoCit)-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(HoCit)-Aib-R-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(HoCit)-Aib-R-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(HoCit)-Aib-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(HoCit)-Aib-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(HoCit)-Aib-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(HoCit)-Aib-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(HoCit)-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(HoCit)-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-AR-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-AR-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-A-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-A-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-A-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-A-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-R-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-R-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQL-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AR-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-AR-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-Aib-(Bip(OMe))-(APPA)'
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-R-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-R-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Har-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-AR-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-AR-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-R-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-R-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Orn-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-AR-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-AR-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-R-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-R-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-Cit-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-AR-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-AR-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-R-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-R-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(HoCit)-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-AR-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-AR-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-A-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-R-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-R-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Cit-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Cit-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Aib-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-Aib-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
(AC5C)-V-Aib-EIQ-(α-Me-2,6-F-Phe)-Nle-HQ-(α-Me-2,6-F-Phe)-Aib-(α-Me-2,6-F-Phe)-(Bip(OMe))-(APPA);
Aib-V-Aib-EIQLMHQ-Har-AK-(αMe-Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-AK-(αMe-Bip(OMe))-(APPA);
V-Aib-V-Aib-EIQLMHQ-Har-AK-(Bip(OMe))-(αMe-APPA);
V-Aib-V-Aib-EIQL-Nle-HQ-Har-AK-(Bip(OMe))-(αMe-APPA);
(αMe-V)-(AC5C)-V-Aib-EIQLMHQ-Har-AK-(Bip(OMe))-(αMe-APPA);
(αMe-V)-(AC5C)-V-Aib-EIQL-Nle-HQ-Har-AK-(Bip(OMe))-(αMe-APPA);
(NMe-V)-(AC5C)-V-Aib-EIQLMHQ-Har-AK-(Bip(OMe))-(αMe-APPA);
(NMe-V)-(AC5C)-V-Aib-EIQL-Nle-HQ-Har-AK-(Bip(OMe))-(αMe-APPA);
Aib-V-Aib-EIQLMHQ-Har-A-Har-(αMe-Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-A-Har-(αMe-Bip(OMe))-(APPA);
Aib-V-Aib-EIQLMHQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
Aib-V-Aib-EIQL-Nle-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
V-Aib-V-Aib-EIQLMHQ-Har-A-Har-(αMe-Bip(OMe))-(APPA);
V-Aib-V-Aib-EIQL-Nle-HQ-Har-A-Har-(αMe-Bip(OMe))-(APPA);
V-Aib-V-Aib-EIQLMHQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
V-Aib-V-Aib-EIQL-Nle-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
(αMe-V)-(AC5C)-V-Aib-EIQLMHQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
(αMe-V)-(AC5C)-V-Aib-EIQL-Nle-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
(NMe-V)-(AC5C)-V-Aib-EIQLMHQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
(NMe-V)-(AC5C)-V-Aib-EIQL-Nle-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
Aib-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-Bip(OMe))-(APPA);
Aib-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
Aib-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
V-Aib-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-Bip(OMe))-(APPA);
V-Aib-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-Bip(OMe))-(APPA);
V-(AC3C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-Bip(OMe))-(APPA);
V-(AC3C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-Bip(OMe))-(APPA);
V-(AC5C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-Bip(OMe))-(APPA);
V-(AC5C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-Bip(OMe))-(APPA);
V-Aib-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
V-Aib-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
V-(AC3C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
V-(AC3C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
V-(AC5C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
V-(AC5C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
(αMe-V)-(AC5C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
(αMe-V)-(AC5C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
(NMe-V)-(AC5C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
(NMe-V)-(AC5C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(Bip(OMe))-(αMe-APPA);
Aib-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-2FPhe)-(APPA);
Aib-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-2FPhe)-(APPA);
V-Aib-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-2FPhe)-(αMe-APPA);
V-Aib-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-2FPhe)-(αMe-APPA);
V-(AC3C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-2FPhe)-(αMe-APPA);
V-(AC3C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-2FPhe)-(αMe-APPA);
V-(AC5C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-2FPhe)-(αMe-APPA);
V-(AC5C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-2FPhe)-(αMe-APPA);
(αMe-V)-(AC5C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-2FPhe)-(αMe-APPA);
(αMe-V)-(AC5C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-2FPhe)-(αMe-APPA);
(NMe-V)-(AC5C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-2FPhe)-(αMe-APPA);
(NMe-V)-(AC5C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-2FPhe)-(αMe-APPA);
Aib-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-Trp)-(APPA);
Aib-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-Trp)-(APPA);
(AC3C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-Trp)-(APPA);
(AC3C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-Trp)-(APPA);
(AC5C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-Trp)-(APPA);
(AC5C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-Trp)-(APPA);
Aib-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-Trp)-(αMe-APPA);
Aib-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-Trp)-(αMe-APPA);
V-(AC3C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-Trp)-(αMe-APPA);
V-(AC3C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-Trp)-(αMe-APPA);
V-(AC5C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-Trp)-(αMe-APPA);
V-(AC5C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-Trp)-(αMe-APPA);
(αMe-V)-(AC5C)-V-Aib-EIQL-(αMe-M)-HQ-Har-A-Har-(αMe-Trp)-(αMe-APPA);
(αMe-V)-(AC5C)-V-Aib-EIQL-(αMe-Nle)-HQ-Har-A-Har-(αMe-Trp)-(αMe-APPA). - 제 1 항 내지 제 17 항 중 어느 한 항에 따른 화학식 1 의 화합물 및 적절한 약제학적으로 허용되는 부형제를 포함하는 약제학적 조성물.
- PTH-1 수용체의 작용물질로서 작용하는, 제 1 항 내지 제 18 항 중 어느 한 항에 따른 화학식 1 의 화합물 또는 이의 약제학적 조성물.
골다공증, 특히 초기 골다공증, 내분비성 골다공증(endocrine osteoporosis), 폐경후 골다공증, 유전적이고 선천적인 형태의 골다공증의 진행 또는 발현을 지연시키거나 치료하기 위한, 제 1 항 내지 제 18 항 중 어느 한 항에 따른 화합물 또는 이의 약제학적 조성물. - 초기 골다공증, 내분비성 골다공증, 유전적이고 선천적인 형태의 골다공증, 부동화(immobilization), 만성 폐쇄성 폐질환(chronic obstructive pulmonary disease) 또는 류마티스성 질환(류마티스 관절염, 척추염)에 의한 골다공증에 의해 발생된 질병의 예방 및 치료방법.
제 1 항 내지 제 19 항 중 어느 한 항에 따른 화학식 1 의 화합물을 이를 필요로 하는 환자에게 독성을 나타내지 않는 유효량으로 투여하는 것을 포함하는, 골수염 또는 뼈 손실의 합병증을 유발하는 뼈에서의 전염성 병변(infectious lesion in bone). - 제 1 항 내지 제 20 항 중 어느 한 항에 따른 화학식 1 의 화합물 및 약제학적으로 허용되는 담체, 희석제, 부형체 또는 용매화합물을 이를 필요로 하는 환자에게 투여하는 것을 포함하는, 제 1 항 내지 제 20 항 중 어느 한 항에 따른 질병 증상을 치료/감소시키기 위한 의약.
- 제 1 항 내지 제 21 항 중 어느 한 항에 따른 질병을 치료하기 적합한 치료제로서, 제 1 항 내지 제 21 항 중 어느 한 항에 따른 화학식 1 의 화합물, 이의 약제학적 조성물 및 이를 포함하는 의약의 용도.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1095/MUM/2009 | 2009-04-24 | ||
| IN1095MU2009 | 2009-04-24 | ||
| IN225/MUM/2010 | 2010-01-28 | ||
| IN225MU2010 | 2010-01-28 | ||
| PCT/IN2010/000264 WO2010128521A2 (en) | 2009-04-24 | 2010-04-26 | Short-chain peptides as parathyroid hormone (pth) receptor agonist |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20120034606A true KR20120034606A (ko) | 2012-04-12 |
| KR101451470B1 KR101451470B1 (ko) | 2014-10-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| KR1020117026057A KR101451470B1 (ko) | 2009-04-24 | 2010-04-26 | 부갑상선호르몬(ｐｔｈ) 수용체 작용물질로서의 단쇄 펩티드 |
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| US (1) | US8383581B2 (ko) |
| EP (1) | EP2421893A2 (ko) |
| JP (1) | JP5744844B2 (ko) |
| KR (1) | KR101451470B1 (ko) |
| CN (1) | CN102405229A (ko) |
| AU (1) | AU2010245642A1 (ko) |
| BR (1) | BRPI1008103A2 (ko) |
| CA (1) | CA2757874C (ko) |
| EA (1) | EA022212B1 (ko) |
| IL (1) | IL215625A (ko) |
| MX (1) | MX2011010968A (ko) |
| NZ (1) | NZ595437A (ko) |
| SG (1) | SG174532A1 (ko) |
| WO (1) | WO2010128521A2 (ko) |
| ZA (1) | ZA201107078B (ko) |
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|---|---|---|---|---|
| US3928487A (en) * | 1974-11-27 | 1975-12-23 | Standard Oil Co | Alkylation process utilizing hydrofluoric acid with a minor amount of fluorosulfuric acid |
| UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
| CA2822556A1 (en) | 2010-12-30 | 2012-07-05 | Enanta Pharmaceuticals, Inc | Macrocyclic hepatitis c serine protease inhibitors |
| CN103380132B (zh) | 2010-12-30 | 2016-08-31 | 益安药业 | 菲啶大环丙型肝炎丝氨酸蛋白酶抑制剂 |
| WO2012120532A2 (en) | 2011-02-02 | 2012-09-13 | Cadila Healthcare Limited | Cyclic short chain peptides |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
Family Cites Families (14)
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| JP4486256B2 (ja) * | 1998-10-22 | 2010-06-23 | ザ・ジェネラル・ホスピタル・コーポレイション | 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体 |
| EP2030986A1 (en) * | 1999-09-29 | 2009-03-04 | The General Hospital Corporation | Polypeptide derivative of parathyroid hormone (PTH) |
| WO2001023521A2 (en) * | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
| EP1439854B1 (en) * | 2001-07-23 | 2016-12-14 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
| AU2002951372A0 (en) | 2002-09-13 | 2002-09-26 | St Vincent's Institute Of Medical Research | Parathyroid hormone-like polypeptides |
| WO2004067021A1 (en) * | 2003-01-24 | 2004-08-12 | Gardella Thomas J | Conformationally constrained parathyroid hormone (pth) analogs with lactam bridges |
| WO2004093902A1 (en) | 2003-03-19 | 2004-11-04 | The General Hospital Corporation | CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH α-HELIX STABILIZERS |
| JP4871128B2 (ja) | 2003-07-17 | 2012-02-08 | ザ ジェネラル ホスピタル コーポレイション | 高次構造的に制約された副甲状腺ホルモン（ｐｔｈ）アナログ |
| US20070123548A1 (en) | 2004-02-11 | 2007-05-31 | Cowan David J | Pth agonists |
| EP1713815A4 (en) | 2004-02-11 | 2009-03-11 | Smithkline Beecham Corp | PTH AGONISTS |
| ITMI20041440A1 (it) | 2004-07-19 | 2004-10-19 | Abiogen Pharma Spa | Peptidi analoghi del pth-1-11 |
| WO2007130113A2 (en) | 2005-09-06 | 2007-11-15 | Zelos Therapeutics, Inc. | Parathyroid hormone analogues and methods of use |
| EP1961765A1 (en) | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Truncated PTH peptides with a cyclic conformation |
| WO2009017809A2 (en) * | 2007-08-01 | 2009-02-05 | The General Hospital Corporation | Screening methods using g-protein coupled receptors and related compositions |
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2010
- 2010-04-26 MX MX2011010968A patent/MX2011010968A/es active IP Right Grant
- 2010-04-26 SG SG2011068863A patent/SG174532A1/en unknown
- 2010-04-26 EA EA201171292A patent/EA022212B1/ru not_active IP Right Cessation
- 2010-04-26 KR KR1020117026057A patent/KR101451470B1/ko not_active IP Right Cessation
- 2010-04-26 US US13/259,706 patent/US8383581B2/en not_active Expired - Fee Related
- 2010-04-26 WO PCT/IN2010/000264 patent/WO2010128521A2/en active Application Filing
- 2010-04-26 AU AU2010245642A patent/AU2010245642A1/en not_active Abandoned
- 2010-04-26 CA CA2757874A patent/CA2757874C/en not_active Expired - Fee Related
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- 2010-04-26 BR BRPI1008103A patent/BRPI1008103A2/pt not_active IP Right Cessation
- 2010-04-26 NZ NZ595437A patent/NZ595437A/en not_active IP Right Cessation
- 2010-04-26 EP EP10747683.0A patent/EP2421893A2/en not_active Withdrawn
- 2010-04-26 CN CN2010800175792A patent/CN102405229A/zh active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2010245642A1 (en) | 2011-10-27 |
| JP2012524775A (ja) | 2012-10-18 |
| KR101451470B1 (ko) | 2014-10-15 |
| CN102405229A (zh) | 2012-04-04 |
| US8383581B2 (en) | 2013-02-26 |
| EA201171292A1 (ru) | 2012-05-30 |
| US20120108496A1 (en) | 2012-05-03 |
| IL215625A (en) | 2016-12-29 |
| EP2421893A2 (en) | 2012-02-29 |
| IL215625A0 (en) | 2012-01-31 |
| WO2010128521A3 (en) | 2011-03-10 |
| ZA201107078B (en) | 2014-03-26 |
| EA022212B1 (ru) | 2015-11-30 |
| NZ595437A (en) | 2014-03-28 |
| CA2757874C (en) | 2016-02-16 |
| WO2010128521A2 (en) | 2010-11-11 |
| JP5744844B2 (ja) | 2015-07-08 |
| SG174532A1 (en) | 2011-10-28 |
| BRPI1008103A2 (pt) | 2016-05-03 |
| CA2757874A1 (en) | 2010-11-11 |
| MX2011010968A (es) | 2012-01-19 |
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