AU2010245642A1 - Short-chain peptides as parathyroid hormone (PTH) receptor agonist - Google Patents

Short-chain peptides as parathyroid hormone (PTH) receptor agonist Download PDF

Info

Publication number
AU2010245642A1
AU2010245642A1 AU2010245642A AU2010245642A AU2010245642A1 AU 2010245642 A1 AU2010245642 A1 AU 2010245642A1 AU 2010245642 A AU2010245642 A AU 2010245642A AU 2010245642 A AU2010245642 A AU 2010245642A AU 2010245642 A1 AU2010245642 A1 AU 2010245642A1
Authority
AU
Australia
Prior art keywords
aib
phe
eiq
nie
har
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2010245642A
Other languages
English (en)
Inventor
Rajesh Bahekar
Mukul R. Jain
Pankaj R. Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zydus Lifesciences Ltd
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of AU2010245642A1 publication Critical patent/AU2010245642A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/635Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2010245642A 2009-04-24 2010-04-26 Short-chain peptides as parathyroid hormone (PTH) receptor agonist Abandoned AU2010245642A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN1095MU2009 2009-04-24
IN1095/MUM/2009 2009-04-24
IN225/MUM/2010 2010-01-28
IN225MU2010 2010-01-28
PCT/IN2010/000264 WO2010128521A2 (en) 2009-04-24 2010-04-26 Short-chain peptides as parathyroid hormone (pth) receptor agonist

Publications (1)

Publication Number Publication Date
AU2010245642A1 true AU2010245642A1 (en) 2011-10-27

Family

ID=43050579

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010245642A Abandoned AU2010245642A1 (en) 2009-04-24 2010-04-26 Short-chain peptides as parathyroid hormone (PTH) receptor agonist

Country Status (15)

Country Link
US (1) US8383581B2 (enExample)
EP (1) EP2421893A2 (enExample)
JP (1) JP5744844B2 (enExample)
KR (1) KR101451470B1 (enExample)
CN (1) CN102405229A (enExample)
AU (1) AU2010245642A1 (enExample)
BR (1) BRPI1008103A2 (enExample)
CA (1) CA2757874C (enExample)
EA (1) EA022212B1 (enExample)
IL (1) IL215625A (enExample)
MX (1) MX2011010968A (enExample)
NZ (1) NZ595437A (enExample)
SG (1) SG174532A1 (enExample)
WO (1) WO2010128521A2 (enExample)
ZA (1) ZA201107078B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3928487A (en) * 1974-11-27 1975-12-23 Standard Oil Co Alkylation process utilizing hydrofluoric acid with a minor amount of fluorosulfuric acid
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
EP2658858A4 (en) 2010-12-30 2014-06-25 Enanta Pharm Inc MACROCYCLIC INHIBITORS OF HEPATITIS C SERINE PROTEASE PHENANTHRIDINE
MX2013007677A (es) 2010-12-30 2013-07-30 Abbvie Inc Inhibidores macrociclicos de serina proteasa de hepatitis.
WO2012120532A2 (en) 2011-02-02 2012-09-13 Cadila Healthcare Limited Cyclic short chain peptides
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
WO2024187241A1 (en) * 2023-03-16 2024-09-19 The Florey Institute Of Neuroscience And Mental Health Stapled peptides

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1447600A (en) 1998-10-22 2000-05-08 Thomas J. Gardella Bioactive peptides and peptide derivatives of parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp)
AU7734800A (en) * 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
JP4723144B2 (ja) * 1999-09-29 2011-07-13 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモン(pth)のポリペプチド誘導体
CA2454275C (en) * 2001-07-23 2012-10-23 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
AU2002951372A0 (en) 2002-09-13 2002-09-26 St Vincent's Institute Of Medical Research Parathyroid hormone-like polypeptides
JP4541899B2 (ja) 2003-01-24 2010-09-08 ザ ジェネラル ホスピタル コーポレイション ラクタム架橋を有する、コンホメーションが制限された副甲状腺ホルモン(pth)アナログ
EP2201960A1 (en) * 2003-03-19 2010-06-30 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
JP4871128B2 (ja) 2003-07-17 2012-02-08 ザ ジェネラル ホスピタル コーポレイション 高次構造的に制約された副甲状腺ホルモン(pth)アナログ
US20070123548A1 (en) 2004-02-11 2007-05-31 Cowan David J Pth agonists
JP2007522214A (ja) 2004-02-11 2007-08-09 スミスクライン・ビーチャム・コーポレイション Pthアゴニスト
ITMI20041440A1 (it) 2004-07-19 2004-10-19 Abiogen Pharma Spa Peptidi analoghi del pth-1-11
CA2621264A1 (en) 2005-09-06 2007-11-15 Zelos Therapeutics, Inc. Parathyroid hormone analogues and methods of use
EP1961765A1 (en) 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
MX353986B (es) * 2007-08-01 2017-11-06 Massachusetts Gen Hospital Metodos de analisis y seleccion usando receptores acoplados a proteina g y composiciones relacionadas.

Also Published As

Publication number Publication date
WO2010128521A3 (en) 2011-03-10
KR101451470B1 (ko) 2014-10-15
JP2012524775A (ja) 2012-10-18
CN102405229A (zh) 2012-04-04
US8383581B2 (en) 2013-02-26
IL215625A (en) 2016-12-29
WO2010128521A2 (en) 2010-11-11
EA022212B1 (ru) 2015-11-30
EA201171292A1 (ru) 2012-05-30
CA2757874C (en) 2016-02-16
KR20120034606A (ko) 2012-04-12
BRPI1008103A2 (pt) 2016-05-03
NZ595437A (en) 2014-03-28
EP2421893A2 (en) 2012-02-29
MX2011010968A (es) 2012-01-19
IL215625A0 (en) 2012-01-31
JP5744844B2 (ja) 2015-07-08
SG174532A1 (en) 2011-10-28
CA2757874A1 (en) 2010-11-11
ZA201107078B (en) 2014-03-26
US20120108496A1 (en) 2012-05-03

Similar Documents

Publication Publication Date Title
CA2757874C (en) Short-chain peptides as parathyroid hormone (pth) receptor agonist
FI104253B (fi) Menetelmä terapeuttisesti käyttökelpoisten nonapeptidibombesiiniantagonistien valmistamiseksi
JP4541899B2 (ja) ラクタム架橋を有する、コンホメーションが制限された副甲状腺ホルモン(pth)アナログ
SK283485B6 (sk) Deriváty parathormónu, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú
WO2014049610A2 (en) Peptides as gip, glp-1 and glucagon receptors triple-agonist
JP4334480B2 (ja) α−ヘリックス安定化剤を用いる高次構造的に制約された副甲状腺ホルモン
PT2213680E (pt) Péptidos que possuem uma atividade farmacológica para o tratamento de distúrbios associados à migração de células alteradas, tais como o cancro
CA3156847A1 (en) Active polypeptide compound
Kowalczyk et al. Synthesis and evaluation of disulfide bond mimetics of amylin-(1–8) as agents to treat osteoporosis
HRP970416A2 (en) Method for the synthesis of analogs of parathyroid hormone and parathyroid hormone related peptide
KR101108354B1 (ko) Pth 수용체 조절제로서의 페길화된 pth 및 그의 용도
JPH10510814A (ja) ベタイドを製造するためのアミノ酸並びにベタイドライブラリーのスクリーニング方法及び製造方法
HUT69708A (en) Process for producing parathormon fragments and pharmaceutical compositions containing them
EP2393832B1 (en) Truncated cystine-knot proteins
EP0773958A1 (en) PTH OR PTHrP ANTAGONISTS
WO2012120532A2 (en) Cyclic short chain peptides
KR20250140094A (ko) Gip/glp1/gcg 삼중-수용체 효능제 및 그의 용도
JPH07316195A (ja) 新規なPTHrP関連ペプチド及びその用途
AU736207B2 (en) Peptides which promote activation of latent TGF-beta and method of screening TGF-beta activity-regulating compounds
Rajeswaran et al. Exploration of the DTrp-NMeLys motif in the search for potent somatostatin antagonists
HK1168863A (en) Short-chain peptides as parathyroid hormone (pth) receptor agonist
Fragiadaki et al. Synthesis and biological evaluation of oxytocin analogues containing l-α-t-butylglycine [Gly (But)] in positions 8 or 9
HK40070508B (zh) 活性多肽化合物
EP0770623A1 (en) Novel calcitonin derivatives
Klasová et al. Effect of N-methylation of the peptide bond in the C-terminal part of the B-chain of human insulin on biological activity

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted