CN102391359A - 组蛋白去乙酰化酶抑制剂及其合成方法和制药用途 - Google Patents
组蛋白去乙酰化酶抑制剂及其合成方法和制药用途 Download PDFInfo
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- CN102391359A CN102391359A CN2011103645457A CN201110364545A CN102391359A CN 102391359 A CN102391359 A CN 102391359A CN 2011103645457 A CN2011103645457 A CN 2011103645457A CN 201110364545 A CN201110364545 A CN 201110364545A CN 102391359 A CN102391359 A CN 102391359A
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Abstract
Description
Claims (11)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110364545.7A CN102391359B (zh) | 2011-11-17 | 2011-11-17 | 组蛋白去乙酰化酶抑制剂及其合成方法和制药用途 |
PCT/CN2012/071515 WO2013071715A1 (zh) | 2011-11-17 | 2012-02-23 | 组蛋白去乙酰化酶抑制剂及其合成方法和制药用途 |
US13/980,308 US8933195B2 (en) | 2011-11-17 | 2012-02-23 | Histone deacetylase inhibitors and synthetic method thereof and use thereof in manufacture of medicaments |
Applications Claiming Priority (1)
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CN201110364545.7A CN102391359B (zh) | 2011-11-17 | 2011-11-17 | 组蛋白去乙酰化酶抑制剂及其合成方法和制药用途 |
Publications (2)
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CN102391359A true CN102391359A (zh) | 2012-03-28 |
CN102391359B CN102391359B (zh) | 2014-07-16 |
Family
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CN201110364545.7A Expired - Fee Related CN102391359B (zh) | 2011-11-17 | 2011-11-17 | 组蛋白去乙酰化酶抑制剂及其合成方法和制药用途 |
Country Status (3)
Country | Link |
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US (1) | US8933195B2 (zh) |
CN (1) | CN102391359B (zh) |
WO (1) | WO2013071715A1 (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103232474A (zh) * | 2013-04-16 | 2013-08-07 | 中国药科大学 | 组蛋白去乙酰化酶抑制剂 |
CN103524598A (zh) * | 2013-09-02 | 2014-01-22 | 上海冠宇生物医药科技有限公司 | 一类环肽类化合物、其制备方法、药物组合物及用途 |
CN103664734A (zh) * | 2013-12-10 | 2014-03-26 | 广州康缔安生物科技有限公司 | 杂环羟肟酸类化合物及其药用组合物和应用 |
CN105131082A (zh) * | 2015-09-17 | 2015-12-09 | 广州康缔安生物科技有限公司 | 环肽类化合物及其应用 |
CN105294552A (zh) * | 2015-11-26 | 2016-02-03 | 上海应用技术学院 | 一种多取代吡啶类医药中间体及其合成方法 |
CN108956565A (zh) * | 2018-06-28 | 2018-12-07 | 中山大学 | 一种荧光探针及在检测sirt2酶活性中的应用 |
US10953011B2 (en) | 2019-05-31 | 2021-03-23 | Viracta Therapeutics Inc. | Methods of treating virally associated cancers with histone deacetylase inhibitors |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE030812T2 (en) * | 2010-05-27 | 2017-05-29 | Univ Colorado Regents | Macrocyclic compounds useful as inhibitors of histone deacetylases |
TWI683823B (zh) * | 2014-05-27 | 2020-02-01 | 美商昂克爾公司 | 製備環縮肽之方法 |
CA2978730A1 (en) * | 2015-03-06 | 2016-09-15 | Colorado State University Research Foundation | Synthesis and utility of new capgroup largazole analogs |
CA3025045A1 (en) * | 2016-05-20 | 2017-11-23 | Onkure, Inc. | Thioester prodrugs of macrocycles as inhibitors of histone deacetylases |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010009334A1 (en) * | 2008-07-17 | 2010-01-21 | Colorado State University Research Foundation | Method for preparing largazole analogs and uses thereof |
WO2011038224A1 (en) * | 2009-09-24 | 2011-03-31 | Trustees Of Boston University | Methods for treating viral disorders |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE030812T2 (en) * | 2010-05-27 | 2017-05-29 | Univ Colorado Regents | Macrocyclic compounds useful as inhibitors of histone deacetylases |
-
2011
- 2011-11-17 CN CN201110364545.7A patent/CN102391359B/zh not_active Expired - Fee Related
-
2012
- 2012-02-23 US US13/980,308 patent/US8933195B2/en not_active Expired - Fee Related
- 2012-02-23 WO PCT/CN2012/071515 patent/WO2013071715A1/zh active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010009334A1 (en) * | 2008-07-17 | 2010-01-21 | Colorado State University Research Foundation | Method for preparing largazole analogs and uses thereof |
WO2011038224A1 (en) * | 2009-09-24 | 2011-03-31 | Trustees Of Boston University | Methods for treating viral disorders |
Non-Patent Citations (2)
Title |
---|
SHANG LI ET AL.: "Synthetic Routes and Biological Evaluation of Largazole and Its Analogues as Potent Histone Deacetylase Inhibitors", 《MOLECULES》 * |
YONGCHENGYING ET AL.: "Total Synthesis and Molecular Target of Largazole, a Histone Deacetylase Inhibitor", 《J. AM. CHEM. SOC.》 * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103232474A (zh) * | 2013-04-16 | 2013-08-07 | 中国药科大学 | 组蛋白去乙酰化酶抑制剂 |
US10065990B2 (en) | 2013-09-02 | 2018-09-04 | Hangzhou Guanyu Bio-Medical Co., Ltd. | Cyclic peptide compound, and preparation method, pharmaceutical composition and use thereof |
WO2015027959A1 (zh) | 2013-09-02 | 2015-03-05 | 上海冠宇生物医药科技有限公司 | 一类环肽类化合物、其制备方法、药物组合物及用途 |
JP2016530286A (ja) * | 2013-09-02 | 2016-09-29 | 上海冠宇生物医▲薬▼科技有限公司 | 環状ペプチド化合物、その製造方法、医薬組成物および用途 |
CN106800589A (zh) * | 2013-09-02 | 2017-06-06 | 李铁旦 | 一类环肽类化合物、其制备方法、药物组合物及用途 |
CN103524598A (zh) * | 2013-09-02 | 2014-01-22 | 上海冠宇生物医药科技有限公司 | 一类环肽类化合物、其制备方法、药物组合物及用途 |
CN106800589B (zh) * | 2013-09-02 | 2021-01-12 | 李铁旦 | 一类环肽类化合物、其制备方法、药物组合物及用途 |
CN103664734A (zh) * | 2013-12-10 | 2014-03-26 | 广州康缔安生物科技有限公司 | 杂环羟肟酸类化合物及其药用组合物和应用 |
CN103664734B (zh) * | 2013-12-10 | 2015-09-23 | 广州康缔安生物科技有限公司 | 杂环羟肟酸类化合物及其药用组合物和应用 |
CN105131082A (zh) * | 2015-09-17 | 2015-12-09 | 广州康缔安生物科技有限公司 | 环肽类化合物及其应用 |
CN105294552A (zh) * | 2015-11-26 | 2016-02-03 | 上海应用技术学院 | 一种多取代吡啶类医药中间体及其合成方法 |
CN108956565A (zh) * | 2018-06-28 | 2018-12-07 | 中山大学 | 一种荧光探针及在检测sirt2酶活性中的应用 |
US10953011B2 (en) | 2019-05-31 | 2021-03-23 | Viracta Therapeutics Inc. | Methods of treating virally associated cancers with histone deacetylase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
WO2013071715A1 (zh) | 2013-05-23 |
CN102391359B (zh) | 2014-07-16 |
US20140243501A1 (en) | 2014-08-28 |
US8933195B2 (en) | 2015-01-13 |
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