CN102365091A - 用于预防或改善胃肠道疾病的组合物 - Google Patents
用于预防或改善胃肠道疾病的组合物 Download PDFInfo
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- CN102365091A CN102365091A CN2010800139052A CN201080013905A CN102365091A CN 102365091 A CN102365091 A CN 102365091A CN 2010800139052 A CN2010800139052 A CN 2010800139052A CN 201080013905 A CN201080013905 A CN 201080013905A CN 102365091 A CN102365091 A CN 102365091A
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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| KR1020090021867A KR101099004B1 (ko) | 2009-03-13 | 2009-03-13 | 위장질환의 예방 또는 개선용 조성물 |
| KR10-2009-0021867 | 2009-03-13 | ||
| PCT/KR2010/001450 WO2010104309A2 (ko) | 2009-03-13 | 2010-03-09 | 위장질환의 예방 또는 개선용 조성물 |
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| CN201410474873.6A Division CN104248666A (zh) | 2009-03-13 | 2010-03-09 | 用于预防或改善胃肠道疾病的组合物 |
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| CN201410474873.6A Pending CN104248666A (zh) | 2009-03-13 | 2010-03-09 | 用于预防或改善胃肠道疾病的组合物 |
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| CN201410474873.6A Pending CN104248666A (zh) | 2009-03-13 | 2010-03-09 | 用于预防或改善胃肠道疾病的组合物 |
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| KR (1) | KR101099004B1 (pt) |
| CN (2) | CN102365091A (pt) |
| BR (1) | BRPI1009105A2 (pt) |
| MY (1) | MY160409A (pt) |
| RU (1) | RU2500416C2 (pt) |
| UA (1) | UA99685C2 (pt) |
| WO (1) | WO2010104309A2 (pt) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102631432A (zh) * | 2012-05-10 | 2012-08-15 | 黄炳炎 | 一种防治亚健康的中药组合物 |
| CN103005063A (zh) * | 2013-01-06 | 2013-04-03 | 江西省蚕桑茶叶研究所 | 一种金佛手袋泡茶 |
| CN103432276A (zh) * | 2013-09-16 | 2013-12-11 | 河北科技师范学院 | 治疗仔猪急性副伤寒的中草药口服液 |
| CN104800309A (zh) * | 2010-05-06 | 2015-07-29 | Cj医药健康株式会社 | 用于预防、治疗或改善胃肠运动障碍性疾病的药物组合物和健康功能食品组合物 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600284A (zh) * | 2011-01-21 | 2012-07-25 | 李艳娜 | 一种治疗慢性结肠炎、直肠炎的中药灌肠剂 |
| KR20110056459A (ko) * | 2011-04-04 | 2011-05-30 | 정필구 | 치주질환의 예방 및 개선용 조성물 |
| CN102697926B (zh) * | 2012-06-12 | 2013-11-27 | 查迅 | 治疗溃疡性结肠炎的中药软膏及其制备方法 |
| KR20140033998A (ko) * | 2012-09-11 | 2014-03-19 | 씨제이제일제당 (주) | 사이코사포닌 ａ, 베르베린 및 리코이소플라본 ｂ를 포함하는 위장질환의 예방 또는 치료용 조성물 |
| CN103223025A (zh) * | 2013-05-21 | 2013-07-31 | 卫斌 | 一种治疗胃炎的药物及其制备方法 |
| CN104622989A (zh) * | 2015-01-15 | 2015-05-20 | 西安医学院 | 一种中药复方灭菌剂及其制备方法 |
| KR102634898B1 (ko) | 2015-11-06 | 2024-02-08 | 주식회사 제뉴원사이언스 | 시호, 승마, 백작약 및 목향 혼합 추출물을 함유하는 염증성 장질환의 예방 및 치료용 약학 조성물 |
| KR102434265B1 (ko) * | 2017-09-20 | 2022-08-19 | 밍츄 리 | 위궤양 치료용 한방약 |
| KR102428859B1 (ko) * | 2020-05-29 | 2022-08-04 | 동성제약주식회사 | 안전성이 확보된 소화기계 질환 예방 또는 치료를 위한 경구투여용 약학 조성물 |
Citations (3)
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|---|---|---|---|---|
| CN101167921A (zh) * | 2007-11-07 | 2008-04-30 | 北京中科雍和医药技术有限公司 | 一种治疗胃痛的药物组合物及其制备方法 |
| CN101209340A (zh) * | 2006-12-25 | 2008-07-02 | 上海中医药大学附属岳阳中西医结合医院 | 治疗胃食管反流病的中药组合物 |
| CN101342282A (zh) * | 2007-07-11 | 2009-01-14 | 大百汇生物科技（深圳）有限公司 | 一种治疗胃病的中药组合物及制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106678A (zh) * | 1994-08-23 | 1995-08-16 | 路良宇 | 治疗胃肠炎、溃疡的药物和工艺 |
| US6365198B1 (en) | 2001-01-28 | 2002-04-02 | Gulf Pharmaceutical Industries | Pharmaceutical preparation for the treatment of gastrointestinal ulcers and hemorrhoids |
| US7198804B2 (en) * | 2002-04-12 | 2007-04-03 | Helixir Co., Ltd. | Crude drug composition for preventing and treating gastrointestinal dyskinetic diseases |
| CN1579485B (zh) * | 2004-03-16 | 2010-04-28 | 南京师范大学 | 治疗肠功能紊乱的中药组合物及其制备方法 |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101209340A (zh) * | 2006-12-25 | 2008-07-02 | 上海中医药大学附属岳阳中西医结合医院 | 治疗胃食管反流病的中药组合物 |
| CN101342282A (zh) * | 2007-07-11 | 2009-01-14 | 大百汇生物科技（深圳）有限公司 | 一种治疗胃病的中药组合物及制备方法 |
| CN101167921A (zh) * | 2007-11-07 | 2008-04-30 | 北京中科雍和医药技术有限公司 | 一种治疗胃痛的药物组合物及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| ALY,A.M ET AL: "《A Possible anti-inflammatory and anti-ulcer drug》", 《AAPS PHAEMSCITECH》 * |
| HIRANO,H.ET AL: "《Gastric-mucous Membrane Protection activity of coptisine derivatives》", 《BIOLOGICAL ＆ PHARMACEUTICAL BULLEETIN》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800309A (zh) * | 2010-05-06 | 2015-07-29 | Cj医药健康株式会社 | 用于预防、治疗或改善胃肠运动障碍性疾病的药物组合物和健康功能食品组合物 |
| CN102631432A (zh) * | 2012-05-10 | 2012-08-15 | 黄炳炎 | 一种防治亚健康的中药组合物 |
| CN102631432B (zh) * | 2012-05-10 | 2013-09-11 | 黄炳炎 | 一种防治亚健康的中药组合物 |
| CN103005063A (zh) * | 2013-01-06 | 2013-04-03 | 江西省蚕桑茶叶研究所 | 一种金佛手袋泡茶 |
| CN103005063B (zh) * | 2013-01-06 | 2014-02-12 | 江西省蚕桑茶叶研究所 | 一种金佛手袋泡茶 |
| CN103432276A (zh) * | 2013-09-16 | 2013-12-11 | 河北科技师范学院 | 治疗仔猪急性副伤寒的中草药口服液 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104248666A (zh) | 2014-12-31 |
| KR101099004B1 (ko) | 2011-12-28 |
| UA99685C2 (ru) | 2012-09-10 |
| WO2010104309A3 (ko) | 2011-01-06 |
| KR20100103305A (ko) | 2010-09-27 |
| BRPI1009105A2 (pt) | 2016-03-08 |
| MY160409A (en) | 2017-03-15 |
| RU2500416C2 (ru) | 2013-12-10 |
| WO2010104309A2 (ko) | 2010-09-16 |
| RU2011141504A (ru) | 2013-04-20 |
| WO2010104309A9 (ko) | 2011-02-24 |
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