CN102358746A - 表面活性钙磷酸盐 - Google Patents
表面活性钙磷酸盐 Download PDFInfo
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- CN102358746A CN102358746A CN2011101626856A CN201110162685A CN102358746A CN 102358746 A CN102358746 A CN 102358746A CN 2011101626856 A CN2011101626856 A CN 2011101626856A CN 201110162685 A CN201110162685 A CN 201110162685A CN 102358746 A CN102358746 A CN 102358746A
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- 239000001506 calcium phosphate Substances 0.000 title claims description 32
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims description 31
- 235000011010 calcium phosphates Nutrition 0.000 title claims description 29
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 39
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 30
- 229910052816 inorganic phosphate Inorganic materials 0.000 claims abstract description 27
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 25
- -1 (-O)- Chemical class 0.000 claims abstract description 20
- 239000008139 complexing agent Substances 0.000 claims abstract description 20
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 9
- 125000003277 amino group Chemical group 0.000 claims abstract description 8
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 6
- 125000000129 anionic group Chemical group 0.000 claims abstract description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 4
- 239000001301 oxygen Chemical group 0.000 claims abstract description 4
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 4
- 239000010452 phosphate Substances 0.000 claims abstract description 4
- 125000000547 substituted alkyl group Chemical group 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims description 89
- 239000000203 mixture Substances 0.000 claims description 41
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 26
- 208000002925 dental caries Diseases 0.000 claims description 26
- 239000003795 chemical substances by application Substances 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 20
- 239000011575 calcium Substances 0.000 claims description 18
- 239000000126 substance Substances 0.000 claims description 15
- 210000000214 mouth Anatomy 0.000 claims description 13
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 12
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
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- 125000003368 amide group Chemical group 0.000 claims description 8
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- 239000013543 active substance Substances 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 7
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 7
- 235000000346 sugar Nutrition 0.000 claims description 7
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- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
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- 235000008733 Citrus aurantifolia Nutrition 0.000 claims description 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims description 5
- 235000011941 Tilia x europaea Nutrition 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 5
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 5
- YYRMJZQKEFZXMX-UHFFFAOYSA-N calcium;phosphoric acid Chemical compound [Ca+2].OP(O)(O)=O.OP(O)(O)=O YYRMJZQKEFZXMX-UHFFFAOYSA-N 0.000 claims description 5
- 150000001768 cations Chemical class 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 239000004571 lime Substances 0.000 claims description 5
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- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 150000005846 sugar alcohols Chemical class 0.000 claims description 5
- 239000002426 superphosphate Substances 0.000 claims description 5
- RADKZDMFGJYCBB-UHFFFAOYSA-N Pyridoxal Chemical compound CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 4
- 229910052783 alkali metal Inorganic materials 0.000 claims description 4
- 150000001340 alkali metals Chemical class 0.000 claims description 4
- 229910052728 basic metal Inorganic materials 0.000 claims description 4
- 150000003818 basic metals Chemical group 0.000 claims description 4
- 125000002091 cationic group Chemical group 0.000 claims description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 4
- 235000015097 nutrients Nutrition 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 4
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- 238000006366 phosphorylation reaction Methods 0.000 claims description 4
- 230000002087 whitening effect Effects 0.000 claims description 4
- 229930182558 Sterol Natural products 0.000 claims description 3
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical group [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims description 3
- 230000008859 change Effects 0.000 claims description 3
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- 235000019691 monocalcium phosphate Nutrition 0.000 claims description 3
- 229910000150 monocalcium phosphate Inorganic materials 0.000 claims description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 3
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- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
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- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 239000000376 reactant Substances 0.000 claims description 3
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims description 2
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims description 2
- SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical compound NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 claims description 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims description 2
- 238000005576 amination reaction Methods 0.000 claims description 2
- 230000002882 anti-plaque Effects 0.000 claims description 2
- 239000003975 dentin desensitizing agent Substances 0.000 claims description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims description 2
- 239000000975 dye Substances 0.000 claims description 2
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- 229960002154 guar gum Drugs 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
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- 239000003921 oil Substances 0.000 claims description 2
- 239000000049 pigment Substances 0.000 claims description 2
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- 239000011674 pyridoxal Substances 0.000 claims description 2
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- WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 claims description 2
- 229950000975 salicylanilide Drugs 0.000 claims description 2
- 238000010186 staining Methods 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 claims description 2
- 239000000080 wetting agent Substances 0.000 claims description 2
- 150000003512 tertiary amines Chemical class 0.000 claims 2
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- BYRJNWIHXADTSH-UHFFFAOYSA-N C(CCCCCCCCCCC)C(C(=O)O)CNCCC(=O)O Chemical compound C(CCCCCCCCCCC)C(C(=O)O)CNCCC(=O)O BYRJNWIHXADTSH-UHFFFAOYSA-N 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract description 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 11
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- 229910052731 fluorine Inorganic materials 0.000 description 9
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- 235000009508 confectionery Nutrition 0.000 description 8
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- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical class [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Birds (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75133505P | 2005-12-16 | 2005-12-16 | |
| US60/751,335 | 2005-12-16 |
Related Parent Applications (1)
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| CNA2006800470142A Division CN101330943A (zh) | 2005-12-16 | 2006-12-15 | 表面活性钙磷酸盐 |
Publications (1)
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|---|---|
| CN102358746A true CN102358746A (zh) | 2012-02-22 |
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| CN2011101626856A Pending CN102358746A (zh) | 2005-12-16 | 2006-12-15 | 表面活性钙磷酸盐 |
| CNA2006800470142A Pending CN101330943A (zh) | 2005-12-16 | 2006-12-15 | 表面活性钙磷酸盐 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800470142A Pending CN101330943A (zh) | 2005-12-16 | 2006-12-15 | 表面活性钙磷酸盐 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080286216A1 (enExample) |
| EP (1) | EP1960057A4 (enExample) |
| JP (1) | JP2009520694A (enExample) |
| CN (2) | CN102358746A (enExample) |
| AU (1) | AU2006324304A1 (enExample) |
| BR (1) | BRPI0620691A2 (enExample) |
| CA (1) | CA2632009A1 (enExample) |
| WO (1) | WO2007068062A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10130561B2 (en) | 2006-01-31 | 2018-11-20 | Robert L. Karlinsey | Functionalized calcium phosphate hybrid systems for confectionery and foodstuff applications |
| US9205036B2 (en) | 2007-01-31 | 2015-12-08 | Robert Karlinsey | Dental composition |
| US20160317580A9 (en) * | 2007-01-31 | 2016-11-03 | Robert L. Karlinsey | Composition and method for dental remineralization |
| US9023373B2 (en) | 2007-01-31 | 2015-05-05 | Indiana Nanotech | Functionalized calcium phosphate hybrid systems for the remineralization of teeth and a method for producing the same |
| WO2009100263A2 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| EP2249785B2 (en) * | 2008-02-08 | 2019-09-25 | Colgate-Palmolive Company | Arginine salts and their uses for the treatment of illnesses in the oral cavity |
| JP2013510799A (ja) * | 2009-11-11 | 2013-03-28 | オーラル ヘルス オーストラリア ピーティーワイ リミテッド | 抗バイオフィルム糖ペプチド |
| DE102011056018A1 (de) * | 2011-12-05 | 2013-06-06 | Gelita Ag | Zuckersüßware auf Basis eines Gelatinegels und Verfahren zur Herstellung |
| CN104523470A (zh) * | 2014-12-04 | 2015-04-22 | 成都锦汇科技有限公司 | 一种中药健齿牙膏 |
| WO2017044469A1 (en) * | 2015-09-10 | 2017-03-16 | The University Of Florida Research Foundation, Inc. | Arginine-containing restorative dental materials and methods of preventing and controlling caries associated with dental work |
| CN110255502B (zh) * | 2019-06-14 | 2020-11-06 | 贵州新东浩化工材料科技有限公司 | 白肥制氟化氢联产富钙及普钙工艺 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0491472A2 (en) * | 1990-12-18 | 1992-06-24 | Kao Corporation | Hair cosmetic composition in gel state |
| EP1525878A1 (en) * | 2003-10-23 | 2005-04-27 | GC Corporation | Composition for caries prevention |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3943241A (en) * | 1971-08-30 | 1976-03-09 | General Mills, Inc. | Cariostatic composition |
| US4261911A (en) * | 1978-11-30 | 1981-04-14 | Johnson & Johnson | Phosphitaines |
| US4215064A (en) * | 1978-11-30 | 1980-07-29 | Johnson & Johnson | Phosphobetaines |
| US4380637A (en) * | 1978-11-30 | 1983-04-19 | Johnson & Johnson/Mona Industries, Inc. | Imidazoline phosphobetaines |
| US5130123A (en) * | 1981-03-04 | 1992-07-14 | The University Of Melbourne | Dentifrice |
| US4382046A (en) * | 1981-09-22 | 1983-05-03 | Ceramic Cooling Tower Company | Water cooling tower with layers of multi-cell tiles and spacers |
| SE446595B (sv) * | 1982-11-19 | 1986-09-29 | Chemmar Associates Inc | Sjelvdesinfekterande matta med ett alkylfosfat inforlivat i baksidesbeleggningen |
| US5015628A (en) * | 1986-06-12 | 1991-05-14 | The University Of Melbourne | Anticariogenic phosphopeptides |
| SU1595847A1 (ru) * | 1988-08-08 | 1990-09-30 | Казанский научно-исследовательский технологический и проектный институт химико-фотографической промышленности Производственного объединения "Тасма" | Три-[пиридиний(пиколиний)хлоридо]фосфаты в качестве дубителей желатинсодержащих слоев галогенсеребр ных фотографических материалов |
| FR2647012B1 (fr) * | 1989-05-18 | 1991-07-26 | Oreal | Nouvelles compositions dentifrices a action anti-caries, contenant un fluorure de polymere polycationique |
| US5460803A (en) * | 1989-05-24 | 1995-10-24 | American Dental Association Health Foundation | Methods and compositions for mineralizing and fluoridating calcified tissues |
| FR2648133B1 (fr) * | 1989-06-08 | 1992-02-21 | Sanofi Sa | Lauramides n-substitues, leur preparation et compositions les contenant |
| US5227154A (en) * | 1991-08-22 | 1993-07-13 | The University Of Melbourne | Phosphopeptides for the treatment of dental calculus |
| JP3088156B2 (ja) * | 1991-11-19 | 2000-09-18 | サンスター株式会社 | う蝕・歯周病予防用口腔用組成物 |
| US5762911A (en) * | 1996-03-05 | 1998-06-09 | The Research Foundation Of State University Of New York | Anti-caries oral compositions |
| AUPO566297A0 (en) * | 1997-03-13 | 1997-04-10 | University Of Melbourne, The | Calcium phosphopeptide complexes |
| US5958380A (en) * | 1997-07-07 | 1999-09-28 | Enamelon, Inc. | Chewing gum products and the use thereof for remineralizing subsurface dental lesions and for mineralizing exposed dentinal tubules |
| JPH11246374A (ja) * | 1998-02-25 | 1999-09-14 | Lion Corp | 口腔用組成物 |
| JP3719874B2 (ja) * | 1998-04-24 | 2005-11-24 | サンスター株式会社 | 口腔用組成物 |
| US6436370B1 (en) * | 1999-06-23 | 2002-08-20 | The Research Foundation Of State University Of New York | Dental anti-hypersensitivity composition and method |
| US6180806B1 (en) * | 1999-09-23 | 2001-01-30 | Phoenix Research Corp. | Glyceryl phosphobetaine compounds |
| JP4146980B2 (ja) * | 1999-12-20 | 2008-09-10 | 花王株式会社 | 皮膚洗浄方法 |
| AUPR517701A0 (en) * | 2001-05-21 | 2001-06-14 | University Of Melbourne, The | Dental restorative materials |
| JP2005145952A (ja) * | 2003-10-23 | 2005-06-09 | Gc Corp | う蝕予防用組成物 |
-
2006
- 2006-12-15 WO PCT/AU2006/001914 patent/WO2007068062A1/en not_active Ceased
- 2006-12-15 EP EP06828022A patent/EP1960057A4/en not_active Withdrawn
- 2006-12-15 CA CA002632009A patent/CA2632009A1/en not_active Abandoned
- 2006-12-15 US US12/095,044 patent/US20080286216A1/en not_active Abandoned
- 2006-12-15 CN CN2011101626856A patent/CN102358746A/zh active Pending
- 2006-12-15 JP JP2008544714A patent/JP2009520694A/ja active Pending
- 2006-12-15 AU AU2006324304A patent/AU2006324304A1/en not_active Abandoned
- 2006-12-15 BR BRPI0620691-3A patent/BRPI0620691A2/pt not_active IP Right Cessation
- 2006-12-15 CN CNA2006800470142A patent/CN101330943A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0491472A2 (en) * | 1990-12-18 | 1992-06-24 | Kao Corporation | Hair cosmetic composition in gel state |
| EP1525878A1 (en) * | 2003-10-23 | 2005-04-27 | GC Corporation | Composition for caries prevention |
Non-Patent Citations (2)
| Title |
|---|
| DONALD B. MCCORMICK ET AL.: "Syntheses of 8-bromo-5’-adenylate-containing nucleotides", 《JOURNAL OF MEDICINAL CHEMISTRY》 * |
| FRANCESCA BENEDINI ET AL.: "13C NMR Study of 1-substituyed Imidazoles", 《MAGNETIC RESONANCE IN CHEMISTRY》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2632009A1 (en) | 2007-06-21 |
| BRPI0620691A2 (pt) | 2011-11-22 |
| US20080286216A1 (en) | 2008-11-20 |
| EP1960057A4 (en) | 2013-03-27 |
| AU2006324304A1 (en) | 2007-06-21 |
| CN101330943A (zh) | 2008-12-24 |
| JP2009520694A (ja) | 2009-05-28 |
| EP1960057A1 (en) | 2008-08-27 |
| WO2007068062A1 (en) | 2007-06-21 |
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Application publication date: 20120222 |