CN102333770B - P38map激酶抑制剂 - Google Patents
P38map激酶抑制剂 Download PDFInfo
- Publication number
- CN102333770B CN102333770B CN200980156810.3A CN200980156810A CN102333770B CN 102333770 B CN102333770 B CN 102333770B CN 200980156810 A CN200980156810 A CN 200980156810A CN 102333770 B CN102333770 B CN 102333770B
- Authority
- CN
- China
- Prior art keywords
- nhc
- ureido
- butyl
- tert
- tolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C(C=CC1NC(N*O*N(*)C(*=C)=O)=O)NN1c1ccccc1 Chemical compound *C(C=CC1NC(N*O*N(*)C(*=C)=O)=O)NN1c1ccccc1 0.000 description 28
- LKIBTJHPUXVNGR-XGXWUAJZSA-N C/C=C\C(/C=C/C=C)N Chemical compound C/C=C\C(/C=C/C=C)N LKIBTJHPUXVNGR-XGXWUAJZSA-N 0.000 description 1
- IZDLQERGFYNKQU-UHFFFAOYSA-N CC(C(C1)CC1=N)=O Chemical compound CC(C(C1)CC1=N)=O IZDLQERGFYNKQU-UHFFFAOYSA-N 0.000 description 1
- NHRGEGPCMKOEES-UHFFFAOYSA-N CC(C1)=CCNC1NC Chemical compound CC(C1)=CCNC1NC NHRGEGPCMKOEES-UHFFFAOYSA-N 0.000 description 1
- VRQJXXOWBPVCJW-UHFFFAOYSA-N CC(NC(P)=O)=C Chemical compound CC(NC(P)=O)=C VRQJXXOWBPVCJW-UHFFFAOYSA-N 0.000 description 1
- PKQNMMWEHGWNRV-LJKBVZDXSA-N CCC(CC=C1)C=C1/C(/N)=C\CCCC(C1)CC=N[C@]1(C)NC=O Chemical compound CCC(CC=C1)C=C1/C(/N)=C\CCCC(C1)CC=N[C@]1(C)NC=O PKQNMMWEHGWNRV-LJKBVZDXSA-N 0.000 description 1
- QZWMYNAORXEBCZ-ZXOAYOIJSA-N CCCN(CC)C(NC(N=CC1)=CC1O/C(/C1CC=CCC1)=C/C=C/N)=O Chemical compound CCCN(CC)C(NC(N=CC1)=CC1O/C(/C1CC=CCC1)=C/C=C/N)=O QZWMYNAORXEBCZ-ZXOAYOIJSA-N 0.000 description 1
- CQFJTTGRYMIUSN-UHFFFAOYSA-N CCc(cc1NC([n]2cncc2)=O)n[n]1-c1ccccc1 Chemical compound CCc(cc1NC([n]2cncc2)=O)n[n]1-c1ccccc1 CQFJTTGRYMIUSN-UHFFFAOYSA-N 0.000 description 1
- SJRJJKPEHAURKC-UHFFFAOYSA-N CN1CCOCC1 Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 1
- NEEMRGVAVOHCQV-UHFFFAOYSA-N COCCC(NC1=CC(OC(C2=C3CCCC2)=CCC3NC(Nc2cc(C3C=CC3)n[n]2-c2ccc(C3CC3)cc2)O)=CCN1)O Chemical compound COCCC(NC1=CC(OC(C2=C3CCCC2)=CCC3NC(Nc2cc(C3C=CC3)n[n]2-c2ccc(C3CC3)cc2)O)=CCN1)O NEEMRGVAVOHCQV-UHFFFAOYSA-N 0.000 description 1
- XLQJTVFRCZWDRT-UHFFFAOYSA-N COCCOCCOC1C(F)=C(C(O)=O)C(F)=CC1 Chemical compound COCCOCCOC1C(F)=C(C(O)=O)C(F)=CC1 XLQJTVFRCZWDRT-UHFFFAOYSA-N 0.000 description 1
- HFMLLTVIMFEQRE-UHFFFAOYSA-N NC(N=CN1)=CC1=O Chemical compound NC(N=CN1)=CC1=O HFMLLTVIMFEQRE-UHFFFAOYSA-N 0.000 description 1
- KMXDLVFBHWCENV-UHFFFAOYSA-N NC1c2ccccc2C(OC2C=C(N)N=CC2)=CC1 Chemical compound NC1c2ccccc2C(OC2C=C(N)N=CC2)=CC1 KMXDLVFBHWCENV-UHFFFAOYSA-N 0.000 description 1
- DUYYFMPMGYATPO-UHFFFAOYSA-N NCCCCN1CCOCC1 Chemical compound NCCCCN1CCOCC1 DUYYFMPMGYATPO-UHFFFAOYSA-N 0.000 description 1
- NGXSWUFDCSEIOO-SCSAIBSYSA-N N[C@H]1CNCC1 Chemical compound N[C@H]1CNCC1 NGXSWUFDCSEIOO-SCSAIBSYSA-N 0.000 description 1
- MDTQKFBBUHFHPR-UHFFFAOYSA-N Nc(cc1)ccc1OC(C1)NC=NC1C1[IH]C1 Chemical compound Nc(cc1)ccc1OC(C1)NC=NC1C1[IH]C1 MDTQKFBBUHFHPR-UHFFFAOYSA-N 0.000 description 1
- SZRKMAWJPITDIU-UHFFFAOYSA-N O=Nc(c1c2cccc1)ccc2F Chemical compound O=Nc(c1c2cccc1)ccc2F SZRKMAWJPITDIU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0822609.4 | 2008-12-11 | ||
| GB0822609A GB0822609D0 (en) | 2008-12-11 | 2008-12-11 | Novel compounds |
| US16659409P | 2009-04-03 | 2009-04-03 | |
| US61/166594 | 2009-04-03 | ||
| US61/166,594 | 2009-04-03 | ||
| GB0912470A GB0912470D0 (en) | 2009-07-17 | 2009-07-17 | Novel compounds |
| GB0912470.2 | 2009-07-17 | ||
| PCT/GB2009/051702 WO2010067130A1 (en) | 2008-12-11 | 2009-12-11 | P38 map kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102333770A CN102333770A (zh) | 2012-01-25 |
| CN102333770B true CN102333770B (zh) | 2015-01-28 |
Family
ID=42242379
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980156810.3A Expired - Fee Related CN102333770B (zh) | 2008-12-11 | 2009-12-11 | P38map激酶抑制剂 |
| CN200980156757.7A Expired - Fee Related CN102341384B (zh) | 2008-12-11 | 2009-12-11 | P38map激酶抑制剂 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980156757.7A Expired - Fee Related CN102341384B (zh) | 2008-12-11 | 2009-12-11 | P38map激酶抑制剂 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8299073B2 (https=) |
| EP (2) | EP2370428B1 (https=) |
| JP (3) | JP5670912B2 (https=) |
| KR (2) | KR20110094127A (https=) |
| CN (2) | CN102333770B (https=) |
| AU (2) | AU2009326149B2 (https=) |
| BR (1) | BRPI0922962A2 (https=) |
| CA (2) | CA2746354A1 (https=) |
| MX (2) | MX2011006220A (https=) |
| NZ (1) | NZ593104A (https=) |
| WO (2) | WO2010067130A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008337286B2 (en) | 2007-12-19 | 2014-08-07 | Cancer Research Technology Limited | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
| MY159230A (en) * | 2008-10-02 | 2016-12-30 | Respivert Ltd | P38 map kinase inhibitors |
| GB0818033D0 (en) * | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
| JP5670912B2 (ja) * | 2008-12-11 | 2015-02-18 | レスピバート・リミテツド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| GB0905955D0 (en) * | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
| GB0921730D0 (en) * | 2009-12-11 | 2010-01-27 | Respivert Ltd | Method of treatment |
| GB0921731D0 (en) * | 2009-12-11 | 2010-01-27 | Respivert Ltd | Theraputic uses |
| NZ601085A (en) | 2010-02-01 | 2015-04-24 | Cancer Rec Tech Ltd | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy |
| GB201005589D0 (en) | 2010-04-01 | 2010-05-19 | Respivert Ltd | Novel compounds |
| EP2556068B1 (en) | 2010-04-08 | 2019-01-23 | Respivert Limited | P38 map kinase inhibitors |
| WO2011124923A2 (en) | 2010-04-08 | 2011-10-13 | Respivert Limited | Novel compounds |
| GB201009731D0 (en) * | 2010-06-10 | 2010-07-21 | Pulmagen Therapeutics Inflamma | Kinase inhibitors |
| GB201010196D0 (en) * | 2010-06-17 | 2010-07-21 | Respivert Ltd | Methods |
| GB201010193D0 (en) * | 2010-06-17 | 2010-07-21 | Respivert Ltd | Medicinal use |
| US8933228B2 (en) | 2010-06-17 | 2015-01-13 | Respivert, Ltd. | Respiratory formulations and compounds for use therein |
| EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
| CN103917536B (zh) | 2011-10-03 | 2016-07-06 | 瑞斯比维特有限公司 | 1-吡唑基-3-(4-((2-(苯氨基)嘧啶-4-基)氧基)萘-1-基)脲用作p38 MAP激酶抑制剂 |
| DK2788349T3 (en) * | 2011-12-09 | 2017-01-30 | Chiesi Farm Spa | kinase inhibitors |
| GB201214750D0 (en) * | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| EP2890701B1 (en) | 2012-08-29 | 2017-03-29 | Respivert Limited | Kinase inhibitors |
| US20150225373A1 (en) | 2012-08-29 | 2015-08-13 | Respivert Limited | Kinase inhibitors |
| GB201215357D0 (en) | 2012-08-29 | 2012-10-10 | Respivert Ltd | Compounds |
| US20150210722A1 (en) | 2012-08-29 | 2015-07-30 | Respivert Limited | Kinase inhibitors |
| US11052202B2 (en) * | 2012-11-07 | 2021-07-06 | Chiesi Farmaceutici S.P.A. | Drug delivery device for the treatment of patients with respiratory diseases |
| WO2014076484A1 (en) | 2012-11-16 | 2014-05-22 | Respivert Limited | Kinase inhibitors |
| EP2970190A1 (en) | 2013-03-14 | 2016-01-20 | Respivert Limited | Kinase inhibitors |
| KR102283876B1 (ko) | 2013-04-02 | 2021-07-29 | 옥슬러 액퀴지션즈 리미티드 | 키나제 저해제로서 유용한 우레아 유도체 |
| US9771353B2 (en) | 2013-04-02 | 2017-09-26 | Topivert Pharma Limited | Kinase inhibitors based upon N-alkyl pyrazoles |
| GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
| EP3083604A1 (en) | 2013-12-20 | 2016-10-26 | Respivert Limited | Urea derivatives useful as kinase inhibitors |
| ES2677595T3 (es) | 2014-02-14 | 2018-08-03 | Respivert Limited | Compuestos heterocíclicos aromáticos como compuestos antiinflamatorios |
| MA40774A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
| CN108367012B (zh) * | 2015-09-21 | 2021-12-24 | 深圳埃格林医药有限公司 | 自体免疫性和自身炎症性疾病的治疗 |
| CA3015978A1 (en) | 2016-04-06 | 2017-10-12 | Topivert Pharma Limited | Kinase inhibitors |
| PL3601233T3 (pl) | 2017-03-27 | 2025-01-07 | HYDRO-QUéBEC | Sole do zastosowania w kompozycjach elektrolitowych lub jako dodatki do elektrod |
| US11407771B2 (en) | 2018-05-30 | 2022-08-09 | Washington University | Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof |
| KR20220038696A (ko) * | 2019-07-19 | 2022-03-29 | 아나제네시스 바이오테크놀로지스 에스.에이.에스. | 폴리방향족 우레아 유도체 및 근육 질환 치료에서의 이들의 용도 |
| EP4029501A1 (en) | 2021-01-19 | 2022-07-20 | Anagenesis Biotechnologies | Combination of polyaromatic urea derivatives and glucocorticoid or hdac inhibitor for the treatment of diseases or conditions associated with muscle cells and/or satellite cells |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003072569A1 (en) * | 2002-02-25 | 2003-09-04 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases |
| CN1756747A (zh) * | 2002-12-31 | 2006-04-05 | 迪赛孚尔药品研制有限公司 | 抗炎症药物 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999023091A1 (en) | 1997-11-03 | 1999-05-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
| US20080300281A1 (en) | 1997-12-22 | 2008-12-04 | Jacques Dumas | Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas |
| US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
| SK286213B6 (sk) * | 1997-12-22 | 2008-05-06 | Bayer Corporation | Substituované heterocyklické močoviny, farmaceutický prípravok ich obsahujúci a ich použitie |
| ID26328A (id) | 1997-12-22 | 2000-12-14 | Bayer Ag | Penghambat raf kinase menggunakan urea heterosiklik tersubstitusi aril dan heteroaril |
| DE69836563T2 (de) * | 1997-12-22 | 2007-05-16 | Bayer Pharmaceuticals Corp., West Haven | INHIBIERUNG DER p38 KINASE-AKTIVITÄT DURCH DIE VERWENDUNG VON ARYL- UND HETEROARYL-SUBSTITUIERTEN HARNSTOFFEN |
| MXPA00006233A (es) | 1997-12-22 | 2002-09-18 | Bayer Ag | Inhibicion de la actividad de la cinasa p38 utilizando ureas heterociclicas sustituidas. |
| EP1064289A1 (en) | 1998-03-18 | 2001-01-03 | Ariad Pharmaceuticals, Inc. | Heterocyclic signal transduction inhibitors, compositions containing them |
| UA73492C2 (en) * | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
| ATE312823T1 (de) | 1999-07-09 | 2005-12-15 | Boehringer Ingelheim Pharma | Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen |
| US6492529B1 (en) * | 2000-01-18 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Bis pyrazole-1H-pyrazole intermediates and their synthesis |
| US6525046B1 (en) * | 2000-01-18 | 2003-02-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as antiinflammatory agents |
| EP1362037A1 (en) | 2001-02-15 | 2003-11-19 | Boehringer Ingelheim Pharmaceuticals Inc. | Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents |
| WO2002092576A1 (en) | 2001-05-16 | 2002-11-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | Diarylurea derivatives useful as anti-inflammatory agents |
| JP2004536845A (ja) | 2001-07-11 | 2004-12-09 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | サイトカイン媒介疾患の治療方法 |
| US20040023961A1 (en) * | 2002-02-11 | 2004-02-05 | Bayer Corporation | Aryl ureas with raf kinase and angiogenisis inhibiting activity |
| MXPA04007832A (es) | 2002-02-11 | 2005-09-08 | Bayer Pharmaceuticals Corp | Aril-ureas con actividad inhibitoria de angiogenesis. |
| AU2003224025A1 (en) | 2002-04-05 | 2003-10-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | p38 kinase inhibitors for treating mucus hypersecretion |
| US20060063782A1 (en) * | 2002-07-03 | 2006-03-23 | Murray Christopher W | 3-Hetero arylmethoxy ! pyridines and their analogues as p38 map kinase inhibitors |
| US20040110755A1 (en) | 2002-08-13 | 2004-06-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Combination therapy with p38 MAP kinase inhibitors and their pharmaceutical compositions |
| JP2006503025A (ja) | 2002-09-05 | 2006-01-26 | サイオス インク． | ｐ３８ＭＡＰキナーゼの抑制による疼痛治療 |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| DE602004030222D1 (de) | 2003-02-28 | 2011-01-05 | Bayer Healthcare Llc | 2-oxo-1,3,5-perhydrotriazapinderivate, die sich zur behandlung von hyperproliferativen, angiogenen und entzündlichen erkrankungen eignen |
| CA2517517C (en) * | 2003-03-03 | 2012-12-18 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| GB0308511D0 (en) * | 2003-04-14 | 2003-05-21 | Astex Technology Ltd | Pharmaceutical compounds |
| GB0320244D0 (en) * | 2003-05-06 | 2003-10-01 | Aventis Pharma Inc | Pyrazoles as inhibitors of tumour necrosis factor |
| WO2004101529A1 (ja) | 2003-05-19 | 2004-11-25 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環化合物およびその医薬用途 |
| WO2005002673A1 (en) * | 2003-07-03 | 2005-01-13 | Astex Therapeutics Limited | Raf kinase inhibitors |
| CA2536293A1 (en) | 2003-08-22 | 2005-03-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Methods of treating copd and pulmonary hypertension |
| US20050192314A1 (en) | 2003-11-13 | 2005-09-01 | Ambit Biosciences Corporation | Urea derivatives as C-kit modulators |
| WO2006028524A2 (en) | 2004-04-29 | 2006-03-16 | Pharmix Corporation | Compositions and treatments for inhibiting kinase and/or hmg-coa reductase |
| CN101010315A (zh) | 2004-04-30 | 2007-08-01 | 拜耳制药公司 | 用于治疗癌症的取代的吡唑基脲衍生物 |
| ATE460402T1 (de) | 2004-05-12 | 2010-03-15 | Bristol Myers Squibb Co | Für die behandlung von thrombotischen leiden geeignete harnstoffantagonisten des p2y1- rezeptors |
| PT1761520E (pt) | 2004-06-23 | 2008-09-15 | Lilly Co Eli | Inibidores de quinase |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| GB0423554D0 (en) | 2004-10-22 | 2004-11-24 | Cancer Rec Tech Ltd | Therapeutic compounds |
| EP1824843A2 (en) | 2004-12-07 | 2007-08-29 | Locus Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| WO2006068591A1 (en) | 2004-12-20 | 2006-06-29 | Astrazeneca Ab | Novel pyrazole derivatives and their use as modulators of nicotinic acetylcholine receptors |
| WO2006071940A2 (en) | 2004-12-23 | 2006-07-06 | Deciphera Pharmaceuticals, Llc | Enzyme modulators and treatments |
| AU2005325676A1 (en) | 2004-12-23 | 2006-08-03 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| GB0500435D0 (en) * | 2005-01-10 | 2005-02-16 | Novartis Ag | Organic compounds |
| DE102005015253A1 (de) | 2005-04-04 | 2006-10-05 | Merck Patent Gmbh | Pyrazolderivate |
| BRPI0611744B8 (pt) | 2005-06-20 | 2021-05-25 | Janssen R & D Ireland | benzimidazóis heterociclilaminoalquila substituída, seu processo de preparação e composição farmacêutica |
| EP1899299B1 (en) | 2005-06-27 | 2010-10-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| DE102005037499A1 (de) | 2005-08-09 | 2007-02-15 | Merck Patent Gmbh | Pyrazolderivate |
| HRP20130719T1 (en) | 2005-08-24 | 2013-09-30 | Eisai R&D Management Co., Ltd. | Novel pyridine derivative and pyrimidine derivative (3) |
| WO2007038425A2 (en) | 2005-09-27 | 2007-04-05 | Regents Of The University Of Minnesota | Anti-viral compouinds |
| ES2364901T3 (es) | 2005-11-15 | 2011-09-16 | Array Biopharma, Inc. | Procesos e intermedios para la preparación de derivados de n4-fenil-quinazolin-4-amina. |
| EP1960394A2 (en) | 2005-11-15 | 2008-08-27 | Bayer HealthCare AG | Pyrazolyl urea derivatives useful in the treatment of cancer |
| JP2009518298A (ja) * | 2005-12-01 | 2009-05-07 | バイエル ヘルスケア リミティド ライアビリティ カンパニー | 癌治療に有用な尿素化合物 |
| CA2637172A1 (en) | 2006-01-27 | 2007-08-09 | Array Biopharma Inc. | Pyridin-2-amine derivatives and their use as glucokinase activators |
| CA2627692A1 (en) | 2006-01-30 | 2007-08-02 | Irm Llc | Spiro imidazole derivatives as ppar modulators |
| WO2007096764A2 (en) | 2006-02-27 | 2007-08-30 | Glenmark Pharmaceuticals S.A. | Bicyclic heteroaryl derivatives as cannabinoid receptor modulators |
| PE20080538A1 (es) | 2006-08-04 | 2008-06-18 | Takeda Pharmaceutical | Derivado heterociclico fusionado y su uso |
| KR101510356B1 (ko) * | 2008-07-31 | 2015-04-06 | 휴렛-팩커드 디벨롭먼트 컴퍼니, 엘.피. | 광학 신호들을 증폭, 변조 및 검출하기 위한 나노-와이어 광학 블록 디바이스들 |
| GB0818033D0 (en) | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
| MY159230A (en) * | 2008-10-02 | 2016-12-30 | Respivert Ltd | P38 map kinase inhibitors |
| JP5670912B2 (ja) | 2008-12-11 | 2015-02-18 | レスピバート・リミテツド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| GB0905955D0 (en) * | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
-
2009
- 2009-12-11 JP JP2011540219A patent/JP5670912B2/ja active Active
- 2009-12-11 CA CA2746354A patent/CA2746354A1/en not_active Abandoned
- 2009-12-11 CN CN200980156810.3A patent/CN102333770B/zh not_active Expired - Fee Related
- 2009-12-11 WO PCT/GB2009/051702 patent/WO2010067130A1/en not_active Ceased
- 2009-12-11 EP EP09768546.5A patent/EP2370428B1/en active Active
- 2009-12-11 KR KR1020117015734A patent/KR20110094127A/ko not_active Withdrawn
- 2009-12-11 AU AU2009326149A patent/AU2009326149B2/en not_active Ceased
- 2009-12-11 KR KR1020117015760A patent/KR20110094130A/ko not_active Ceased
- 2009-12-11 CN CN200980156757.7A patent/CN102341384B/zh not_active Expired - Fee Related
- 2009-12-11 BR BRPI0922962A patent/BRPI0922962A2/pt not_active IP Right Cessation
- 2009-12-11 US US13/133,998 patent/US8299073B2/en active Active
- 2009-12-11 MX MX2011006220A patent/MX2011006220A/es active IP Right Grant
- 2009-12-11 EP EP09771766.4A patent/EP2370429B1/en active Active
- 2009-12-11 AU AU2009326148A patent/AU2009326148B2/en not_active Ceased
- 2009-12-11 JP JP2011540218A patent/JP2012511563A/ja active Pending
- 2009-12-11 NZ NZ593104A patent/NZ593104A/xx not_active IP Right Cessation
- 2009-12-11 MX MX2011006219A patent/MX2011006219A/es not_active Application Discontinuation
- 2009-12-11 US US13/139,010 patent/US8299074B2/en active Active
- 2009-12-11 WO PCT/GB2009/051703 patent/WO2010067131A1/en not_active Ceased
- 2009-12-11 CA CA2746357A patent/CA2746357A1/en not_active Abandoned
-
2014
- 2014-09-16 JP JP2014187591A patent/JP5959587B2/ja active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003072569A1 (en) * | 2002-02-25 | 2003-09-04 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases |
| CN1756747A (zh) * | 2002-12-31 | 2006-04-05 | 迪赛孚尔药品研制有限公司 | 抗炎症药物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2370428B1 (en) | 2016-08-10 |
| KR20110094130A (ko) | 2011-08-19 |
| JP5670912B2 (ja) | 2015-02-18 |
| CN102341384B (zh) | 2014-11-12 |
| US8299073B2 (en) | 2012-10-30 |
| EP2370429B1 (en) | 2016-04-20 |
| NZ593104A (en) | 2012-11-30 |
| EP2370428A1 (en) | 2011-10-05 |
| WO2010067130A1 (en) | 2010-06-17 |
| AU2009326149A1 (en) | 2010-06-17 |
| US20110294812A1 (en) | 2011-12-01 |
| JP2015013890A (ja) | 2015-01-22 |
| CA2746357A1 (en) | 2010-06-17 |
| MX2011006220A (es) | 2011-06-28 |
| CN102341384A (zh) | 2012-02-01 |
| BRPI0922962A2 (pt) | 2019-09-24 |
| CA2746354A1 (en) | 2010-06-17 |
| MX2011006219A (es) | 2011-06-28 |
| JP2012511564A (ja) | 2012-05-24 |
| AU2009326149B2 (en) | 2014-01-16 |
| WO2010067131A1 (en) | 2010-06-17 |
| US20110312963A1 (en) | 2011-12-22 |
| JP2012511563A (ja) | 2012-05-24 |
| AU2009326148B2 (en) | 2014-05-08 |
| JP5959587B2 (ja) | 2016-08-02 |
| US8299074B2 (en) | 2012-10-30 |
| AU2009326148A1 (en) | 2010-06-17 |
| KR20110094127A (ko) | 2011-08-19 |
| EP2370429A1 (en) | 2011-10-05 |
| WO2010067130A8 (en) | 2011-04-21 |
| CN102333770A (zh) | 2012-01-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102333770B (zh) | P38map激酶抑制剂 | |
| US10000471B2 (en) | Pyrazole P38 map kinase inhibitors | |
| JP5787977B2 (ja) | Ｐ３８ｍａｐキナーゼ阻害剤 | |
| JP5787976B2 (ja) | Ｐ３８ｍａｐキナーゼ阻害剤としてのピラゾリルウレア | |
| JP5973426B2 (ja) | Ｐ３８ｍａｐｋ阻害剤を含む呼吸器用製剤 | |
| CN102256964A (zh) | p38MAP激酶抑制剂 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150128 Termination date: 20151211 |
|
| EXPY | Termination of patent right or utility model |