BRPI0611744B8 - benzimidazóis heterociclilaminoalquila substituída, seu processo de preparação e composição farmacêutica - Google Patents
benzimidazóis heterociclilaminoalquila substituída, seu processo de preparação e composição farmacêuticaInfo
- Publication number
- BRPI0611744B8 BRPI0611744B8 BRPI0611744A BRPI0611744A BRPI0611744B8 BR PI0611744 B8 BRPI0611744 B8 BR PI0611744B8 BR PI0611744 A BRPI0611744 A BR PI0611744A BR PI0611744 A BRPI0611744 A BR PI0611744A BR PI0611744 B8 BRPI0611744 B8 BR PI0611744B8
- Authority
- BR
- Brazil
- Prior art keywords
- 6alkyl
- imidazo
- pyridinyl
- substituted
- heterocycle
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- -1 benzolinyl Chemical group 0.000 abstract 9
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002883 imidazolyl group Chemical group 0.000 abstract 2
- 125000001786 isothiazolyl group Chemical group 0.000 abstract 2
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 2
- 125000002757 morpholinyl group Chemical group 0.000 abstract 2
- 125000001715 oxadiazolyl group Chemical group 0.000 abstract 2
- 125000002971 oxazolyl group Chemical group 0.000 abstract 2
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 2
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 2
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 2
- 125000000335 thiazolyl group Chemical group 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- 125000004568 thiomorpholinyl group Chemical group 0.000 abstract 2
- 125000005988 1,1-dioxo-thiomorpholinyl group Chemical group 0.000 abstract 1
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 abstract 1
- HEAHLTGDUHXTTO-UHFFFAOYSA-N 1,3-thiazolidine 1,1-dioxide Chemical compound O=S1(=O)CCNC1 HEAHLTGDUHXTTO-UHFFFAOYSA-N 0.000 abstract 1
- KZPUZEPLLNUDDZ-UHFFFAOYSA-N 1,3-thiazolidine 1-oxide Chemical compound O=S1CCNC1 KZPUZEPLLNUDDZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000005987 1-oxo-thiomorpholinyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 abstract 1
- AQNQGBUEVCAVML-UHFFFAOYSA-N oxazepane Chemical compound C1CCNOCC1 AQNQGBUEVCAVML-UHFFFAOYSA-N 0.000 abstract 1
- 125000000160 oxazolidinyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000004590 pyridopyridyl group Chemical group N1=C(C=CC2=C1C=CC=N2)* 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- PGAZQSBUJDVGIX-UHFFFAOYSA-N thiazepane Chemical compound C1CCNSCC1 PGAZQSBUJDVGIX-UHFFFAOYSA-N 0.000 abstract 1
- NFRGCMIFZVPLSJ-UHFFFAOYSA-N thiazepane 1,1-dioxide Chemical compound O=S1(=O)CCCCCN1 NFRGCMIFZVPLSJ-UHFFFAOYSA-N 0.000 abstract 1
- HDGIJHACJMJAER-UHFFFAOYSA-N thiazepane 1-oxide Chemical compound O=S1CCCCCN1 HDGIJHACJMJAER-UHFFFAOYSA-N 0.000 abstract 1
- 125000001984 thiazolidinyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
benzimidazóis heterociclilaminoalquila substituída. a presente invenção refere-se a inibidores de benzimidazóis heterociclilaminoalquila de reprodução de rsv de fórmula (i). os sais e formas estereoquimicamente isoméricas destes, no qual q é hidrogênio, c1-6aiquiia opcionalmente substituída com um heterociclo, ou q é c1-6aiquiia substituído com ambos um radical-or4 e um heterociclo; no qual referido heterociclo é oxazolidina, tiazolidina, 1-oxo-tiazolidina, 1,1-dioxotiazolidina, morfolinila, tiomorfolinila, 1-oxo-tiomorfolinila, 1,1 -dioxotiomorfolinila, hexahidrooxazepina, hexahidrotiazepina, 1-oxo-hexahidrotiazepina, 1,1-dioxohexahidrotiazepina, pirrolidina, piperidina, homopiperidina, piperazina; cujo heterociclo pode ser substituído com 1-2 substituintes; cada alk é c1-6alcanodiila; r1 é ar ou opcionalmente piperidinila, piperazinila, morfolinila, tiomorfolinila, piridila, pirazinila, piridazinila, pirimidinila, furanila, tetrahidrofuranila, tienila, pirrolila, tiazolila, oxazolila, imidazolila, isotiazolila, pirazolila, isoxazolila, oxadiazolila, quinolinila, quinoxalinila, benzofuranila, benzotienila, benzimidazolila, benzoxazolila, benztiazolila, piridopiridila, naftiridinila, 1 h- imidazo[4,5-b]piridinila, 3h-imidazo[4,5-b]-piridinila, imidazo[1,2-a]piridinila ou 2,3-dihidro-1,4-dioxino[2,3-b]piridila substituidos; r3 é hidroxic1-6alquila, c1-6alcoxic1-6alquiia, cianoc1-6alquila, aminocarbonilc1-6alquila, mono- ou di(c1-6alquil)aminocarbonilc1-6alquila, carboxic1-6alquila, c1-6alcóxi- carbonilc1-6alquila; r2, r4 e r5 são hidrogênio ou c1-6aiquila; het é piridila, pirazinila, piridazinila, pirimidinila, furanila, tetrahidrofuranila, tienila, pirrolila, tiazolila, oxazolila, im idazolila, isotiazolila, pirazolila, isoxazolila, oxadiazolila, quinolinila, quinoxalinila, benzofuranila, benzotienila, benzimidazolila, benzoxazolila, benztiazolila, piridopiridila, naftiridinila, 1 h-imidazo[4,5-b]piridinila, 3h-imidazo[4,5-b]-piridinila, imidazo[1,2-a]piridinila e 2,3-dihidro-1 ,4-dioxino[2,3-b]piridila; ar é opcionalmente fenila substituído; composições farmacêuticas contendo os compostos (i), e processos para preparação de compostos (i).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05076439.8 | 2005-06-20 | ||
| EP05076439 | 2005-06-20 | ||
| PCT/EP2006/063366 WO2006136562A1 (en) | 2005-06-20 | 2006-06-20 | Heterocyclylaminoalkyl substituted benzimidazoles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0611744A2 BRPI0611744A2 (pt) | 2010-09-28 |
| BRPI0611744B1 BRPI0611744B1 (pt) | 2019-12-03 |
| BRPI0611744B8 true BRPI0611744B8 (pt) | 2021-05-25 |
Family
ID=36954884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0611744A BRPI0611744B8 (pt) | 2005-06-20 | 2006-06-20 | benzimidazóis heterociclilaminoalquila substituída, seu processo de preparação e composição farmacêutica |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8178694B2 (pt) |
| EP (1) | EP1896449B1 (pt) |
| JP (1) | JP5094716B2 (pt) |
| CN (1) | CN101203506B (pt) |
| AU (1) | AU2006260970B2 (pt) |
| BR (1) | BRPI0611744B8 (pt) |
| CA (1) | CA2612264C (pt) |
| ES (1) | ES2444690T3 (pt) |
| MX (1) | MX2007016311A (pt) |
| RU (1) | RU2419613C2 (pt) |
| WO (1) | WO2006136562A1 (pt) |
| ZA (1) | ZA200711084B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102256964A (zh) | 2008-10-02 | 2011-11-23 | 瑞斯比维特有限公司 | p38MAP激酶抑制剂 |
| CA2746354A1 (en) | 2008-12-11 | 2010-06-17 | Respivert Limited | P38 map kinase inhibitors |
| GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
| GB0921731D0 (en) | 2009-12-11 | 2010-01-27 | Respivert Ltd | Theraputic uses |
| GB0921730D0 (en) | 2009-12-11 | 2010-01-27 | Respivert Ltd | Method of treatment |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL200694B1 (pl) | 1999-06-28 | 2009-01-30 | Janssen Pharmaceutica Nv | Pochodna benzoimidazolu lub imidazopirydyny, sposób jej otrzymywania i zastosowanie oraz kompozycja farmaceutyczna i sposób jej otrzymywania |
| ES2228559T3 (es) | 1999-06-28 | 2005-04-16 | Janssen Pharmaceutica N.V. | Inhibidores de la replicacion del virus respiratorio sincintial. |
| DE60008112T2 (de) | 1999-06-28 | 2004-09-16 | Janssen Pharmaceutica N.V. | Respiratorisches syncytialvirus replikation inhibitoren |
| US6489338B2 (en) | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| US7030150B2 (en) | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
| US7244847B2 (en) * | 2002-02-06 | 2007-07-17 | Isis Pharmaceuticals, Inc. | Benzimidazole compounds |
| AR046959A1 (es) | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
| ATE499361T1 (de) * | 2003-12-18 | 2011-03-15 | Tibotec Pharm Ltd | 5- oder 6-substituierte benzimidazolderivate als inhibitoren der replikation des respiratory syncytial virus |
-
2006
- 2006-06-20 US US11/993,126 patent/US8178694B2/en active Active
- 2006-06-20 BR BRPI0611744A patent/BRPI0611744B8/pt not_active IP Right Cessation
- 2006-06-20 ES ES06763809.8T patent/ES2444690T3/es active Active
- 2006-06-20 RU RU2008102065/04A patent/RU2419613C2/ru active
- 2006-06-20 CA CA2612264A patent/CA2612264C/en active Active
- 2006-06-20 CN CN2006800219703A patent/CN101203506B/zh active Active
- 2006-06-20 WO PCT/EP2006/063366 patent/WO2006136562A1/en active Application Filing
- 2006-06-20 AU AU2006260970A patent/AU2006260970B2/en not_active Ceased
- 2006-06-20 EP EP06763809.8A patent/EP1896449B1/en active Active
- 2006-06-20 MX MX2007016311A patent/MX2007016311A/es active IP Right Grant
- 2006-06-20 JP JP2008517488A patent/JP5094716B2/ja active Active
-
2007
- 2007-12-19 ZA ZA200711084A patent/ZA200711084B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2444690T3 (es) | 2014-02-26 |
| RU2419613C2 (ru) | 2011-05-27 |
| RU2008102065A (ru) | 2009-07-27 |
| CA2612264A1 (en) | 2006-12-28 |
| JP5094716B2 (ja) | 2012-12-12 |
| WO2006136562A1 (en) | 2006-12-28 |
| JP2008546739A (ja) | 2008-12-25 |
| AU2006260970A8 (en) | 2006-12-28 |
| US20100272683A1 (en) | 2010-10-28 |
| BRPI0611744B1 (pt) | 2019-12-03 |
| MX2007016311A (es) | 2008-03-07 |
| CN101203506B (zh) | 2012-02-22 |
| BRPI0611744A2 (pt) | 2010-09-28 |
| EP1896449A1 (en) | 2008-03-12 |
| AU2006260970B2 (en) | 2012-07-05 |
| CA2612264C (en) | 2014-09-23 |
| EP1896449B1 (en) | 2013-11-06 |
| ZA200711084B (en) | 2009-03-25 |
| AU2006260970A1 (en) | 2006-12-28 |
| US8178694B2 (en) | 2012-05-15 |
| CN101203506A (zh) | 2008-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: TIBOTEC PHARMACEUTICALS (IE) |
|
| B25D | Requested change of name of applicant approved |
Owner name: JANSSEN R AND D IRELAND (IE) |
|
| B25A | Requested transfer of rights approved |
Owner name: JANSSEN SCIENCES IRELAND UC (IE) |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
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| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
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