CN102333761B - Scriptaid电子等排体及其在治疗中的用途 - Google Patents

Scriptaid电子等排体及其在治疗中的用途 Download PDF

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CN102333761B
CN102333761B CN201080009752.4A CN201080009752A CN102333761B CN 102333761 B CN102333761 B CN 102333761B CN 201080009752 A CN201080009752 A CN 201080009752A CN 102333761 B CN102333761 B CN 102333761B
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pyridine
amino
pyridin
mmol
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CN102333761A (zh
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史蒂芬·约瑟夫·沙特尔沃思
西里列·达维·托马西
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Karus Therapeutics Ltd
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Karus Therapeutics Ltd
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Priority claimed from GB0901406A external-priority patent/GB0901406D0/en
Priority claimed from GB0912383A external-priority patent/GB0912383D0/en
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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010086646A1 (en) * 2009-01-28 2010-08-05 Karus Therapeutics Limited Scriptaid isosteres and their use in therapy
ES2647368T3 (es) 2010-10-08 2017-12-21 Vib Vzw Inhibidores de HDAC para tratar la enfermedad de Charcot-Marie-Tooth
EP2508510A1 (en) 2011-04-06 2012-10-10 Ikerchem, S.L. Hydroxyphenyl pyrrole compounds containing an hydroxamic acid as hdac inhibitors and medicinal applications thereof
KR101415742B1 (ko) 2011-12-21 2014-07-04 영남대학교 산학협력단 6―아미노피리딘―3―올 유도체 또는 이의 약제학적 허용가능한 염 및 이를 유효성분으로 함유하는 혈관신생으로 인한 질환의 예방 또는 치료용 약학조성물
US9889139B2 (en) 2011-12-21 2018-02-13 Research Cooperation Foundation Of Yeungnam University Method of treating inflammatory bowel disease comprising administering a pharmaceutical composition comprising a 6-aminopyridin-3-ol compound or a pharmaceutically acceptable salt thereof as an active ingredient to a subject
IN2015DN03235A (https=) 2012-11-07 2015-10-02 Karus Therapeutics Ltd
WO2014139145A1 (en) * 2013-03-15 2014-09-18 Hutchison Medipharma Limited Novel pyrimidine and pyridine compounds and usage thereof
WO2014153280A1 (en) * 2013-03-22 2014-09-25 Merck Sharp & Dohme Corp. 2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
PT2994465T (pt) * 2013-05-10 2018-10-25 Karus Therapeutics Ltd Novos inibidores de histona desacetilase
GB201419264D0 (en) * 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004076386A2 (en) * 2003-02-25 2004-09-10 Topotarget Uk Limited Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
WO2007050348A2 (en) * 2005-10-21 2007-05-03 Merck & Co., Inc. Potassium channel inhibitors
WO2008007780A1 (fr) * 2006-07-13 2008-01-17 Kyowa Hakko Kirin Co., Ltd. Dérivé du pentadiènamide
WO2008139987A1 (ja) * 2007-04-26 2008-11-20 Japan Science And Technology Agency Ｇタンパク質共役型レセプタ－作動剤

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792562A (en) 1985-12-04 1988-12-20 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing activity
JPH0532662A (ja) 1990-11-09 1993-02-09 Nissan Chem Ind Ltd 置換ピラゾール誘導体および農園芸用殺菌剤
US5214038A (en) 1991-04-15 1993-05-25 Hoechst-Roussel Pharmaceuticals Inc. 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
AU2381397A (en) 1996-04-19 1997-11-12 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
EP0887348A1 (en) * 1997-06-25 1998-12-30 Boehringer Mannheim Italia S.p.A. Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them
JP3712529B2 (ja) * 1998-04-24 2005-11-02 大鵬薬品工業株式会社 ３，３−ジピリジルアクリル酸アミド誘導体又はその薬学的に許容される塩
GB9929988D0 (en) * 1999-12-17 2000-02-09 Celltech Therapeutics Ltd Chemical compounds
US6905669B2 (en) 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
MXPA04008797A (es) 2002-03-13 2004-11-26 Janssen Pharmaceutica Nv Inhibidores de histona desacetilasa.
JP4235726B2 (ja) 2002-11-19 2009-03-11 国立大学法人 奈良先端科学技術大学院大学 大きな二光子吸収特性を示すアセチレン結合により連結されたビス（イミダゾリルポルフィリン金属錯体）を構成単位とするポルフィリン連鎖体及びその製造方法
AU2003900608A0 (en) * 2003-02-11 2003-02-27 Fujisawa Pharmaceutical Co., Ltd. Hdac inhibitor
EP1809381A2 (en) 2004-10-06 2007-07-25 Recepticon ApS Use of compounds for the prevention of drug-induced cell toxicity
US7772245B2 (en) 2005-02-14 2010-08-10 Miikana Therapeutics, Inc. Inhibitors of histone deacetylase
TW200716545A (en) 2005-06-10 2007-05-01 Sigma Tau Ind Farmaceuti Indole derivatives having anti-tumor activity
WO2007085540A1 (en) 2006-01-27 2007-08-02 Glaxo Group Limited 1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
AU2007296743B2 (en) * 2006-09-11 2012-02-16 Curis, Inc. Tyrosine kinase inhibitors containing a zinc binding moiety
CN105481788A (zh) 2006-10-28 2016-04-13 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
CA2670223A1 (en) 2006-11-22 2008-05-29 Karus Therapeutics Limited Depsipeptides and their therapeutic use
WO2009003240A1 (en) 2007-07-03 2009-01-08 Commonwealth Scientific And Industrial Research Organisation Iron control in leaching
WO2009137462A2 (en) 2008-05-05 2009-11-12 Envivo Pharmaceuticals, Inc. Methods for treating cognitive disorders using inhibitors of histone deacetylase
WO2010086646A1 (en) * 2009-01-28 2010-08-05 Karus Therapeutics Limited Scriptaid isosteres and their use in therapy
AU2012212323A1 (en) 2011-02-01 2013-09-12 The Board Of Trustees Of The University Of Illinois HDAC inhibitors and therapeutic methods using the same
CA2850757A1 (en) 2011-10-03 2013-04-11 The Trustees Of Columbia University In The City Of New York Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1
US9695108B2 (en) 2012-08-23 2017-07-04 Georgetown University Compounds and methods of use thereof for treating tumors
IN2015DN03235A (https=) 2012-11-07 2015-10-02 Karus Therapeutics Ltd
US9169214B2 (en) 2012-12-21 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
PT2994465T (pt) 2013-05-10 2018-10-25 Karus Therapeutics Ltd Novos inibidores de histona desacetilase

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004076386A2 (en) * 2003-02-25 2004-09-10 Topotarget Uk Limited Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
WO2007050348A2 (en) * 2005-10-21 2007-05-03 Merck & Co., Inc. Potassium channel inhibitors
WO2008007780A1 (fr) * 2006-07-13 2008-01-17 Kyowa Hakko Kirin Co., Ltd. Dérivé du pentadiènamide
WO2008139987A1 (ja) * 2007-04-26 2008-11-20 Japan Science And Technology Agency Ｇタンパク質共役型レセプタ－作動剤

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library;Gloria H. Su 等;《Cancer research》;20000615;第60卷(第12期);第3138页右栏第6-8行、图2、第3139页左栏第1-17行 *
antihypertensively active amidoximes;Robert P. Mull等;《Journal of the American chemistry society》;19580720;第80卷(第14期);第3771页表II第6行 *
Design,synthesis, and biological activity of novel PPARγ ligands based on rosiglitazone and 15d-PGJ2;Shinya usui等;《bioorganic & medicinal chemistry letters》;20050315;第15卷(第6期);第1548页化合物13 *
Glucose oxidase mediation by soluble and immobilized electroative detergents;Shaik M. Zakeeruddin等;《biosensors and bioelectronics》;19961231;第11卷(第3期);第306页图1化合物DPA *
Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists;Takayoshi Suzuki等;《J. Med. Chem.》;20081211;第51卷(第23期);第7640页表1化合物11 *
Synthesis and characterization of CuII complexes with amino acid substituted Di(2-pyridyl)amine ligands;Srecko I.等;《european journal of inorganic chemistry》;20070622(第23期);第3687页化合物1 *
Synthesis of N-functionalized 2,2’-dipyridylamine ligands, complexation to ruthenium(II) and anchoring of complexes to papain from papaya latex;Pierre Haquette等;《journal of organometallic chemistry》;20081130;第694卷(第6期);第938页流程图1化合物1a和1b *

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