CN102274263B - Transplanted panax ginseng plant-pilos antler-deer penis capsules and preparation method thereof - Google Patents
Transplanted panax ginseng plant-pilos antler-deer penis capsules and preparation method thereof Download PDFInfo
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Abstract
The invention discloses transplanted panax ginseng plant-pilos antler-deer penis capsules and a preparation method thereof, which belong to the modern field of traditional Chinese medicines and are used for overcoming the defects of inconvenience in taking and non-ideal effect of a folk prescription. The capsules are characterized by being prepared from the following raw materials in parts by weight: 4.0-6.0 parts of transplanted panax ginseng plant, 2-4 parts of epimedium herb, 0.5-1.5 parts of pilos antler and 0.5-1.5 parts of deer penis. The transplanted panax ginseng plant-pilos antler-deer penis capsules have the effects of tonifying and strengthening the constitution, invigorating the kidney, supporting yang, enhancing physical power and promoting health. The capsules are particularly for people suffering from hypoimmunity and fatiguability to take once every three days, 2-4 capsules every time; and the capsules are unsuitable for pregnant women, children and people suffering from hypertension.
Description
Technical field:
The invention belongs to modern Chinese traditional medicine field, relate to a kind of SHANSHEN flimmer capsule and preparation method.
Background technology:
Radix Ginseng is a kind of Chinese medicine and tonic of preciousness, has significant strengthening by means of tonics effect, and various diseases is had to prevention effect.Active or the nonactive chemical composition obtaining from Radix Ginseng can be divided into 5 large classes, and its biological activity order is from low to high saponin, polysaccharide, carbene, flavonoid and volatile oil.So far, from panax species, separated more than 100 kind of ginsenoside, it is main active and the characteristic component of Radix Ginseng; Water soluble polysaccharide includes different types of glycosyl, alduronic acid, and acidic polysaccharose has immunostimulatory activity and immunomodulating and antiproliferative effect; Carbene is the organic compound that a kind of singly-bound and triple bond alternately occur, comprises Radix Ginseng two alkynols, Radix Ginseng three alkynols, acetic acid or linolenic acid at Radix Ginseng; In Radix Ginseng, in total volatile oil, have 36 kinds of terpenoid.Successive dynasties medical book is recorded, and Radix Ginseng has the effect of " evil removing, spasmolytic, improving eyesight, happy, Fructus Alpiniae Oxyphyllae, clothes are made light of one's life by commiting suicide and prolonged life for a long time ".Modern age, Chinese scholars showed the pharmacological research of Radix Ginseng, the effect of the aspects such as Radix Ginseng has that antitumor, defying age, raising immunity, resisting fatigue, promotion albumen and nucleic acid are synthetic, enhancing development, enhancing infection and resistance.Radix Ginseng in the present invention refers to Transplant Wild Ginseng, after little the Park Ginseng of 2-3 transplantation of seedlings, makes the Radix Ginseng of its continued growth about 10 years.
Herba Epimedii another name Herba Epimedii, is a kind of traditional traditional tonic medicine, begins to be loaded in Shennong's Herbal, and be the aerial parts of Semen setariae section herbaceos perennial Herba Epimedii and arrow leaf Herba Epimedii etc., its medicinal history is long.In Herba Epimedii, contain the chemical compositions such as flavone, wood vinegar element, alkaloid and polysaccharide.Li Shizhen (1518-1593 A.D.) claims it to have the effect of " beneficial vital essence, hard muscles and bones, real waist knee joint, heart tonifying power " in Compendium of Material Medica.Modern pharmacology experimentation shows, Herba Epimedii has the cardiovascular and cerebrovascular vessel of increasing blood flow, promotes hemopoietic function, immunologic function and metabolism, and the effect such as kidney invigorating and YANG supporting, defying age and antitumor.
Cornu Cervi Pantotrichum is the young horn of animal in deer family Cervus nippon Temminck or the unossified close raw fine hair of Cervus elaphus linnaeus, and Cornu Cervi Pantotrichum is China's tradition rare Chinese medicine, and its pharmacological action is very extensive.The organic principle containing in Cornu Cervi Pantotrichum mainly contains: 19 seed amino acids, 9 kinds of fatty acids, 10 kinds of phosphatide cpds and cholesterol myristinate, cholesterol grease, cholesterol ester stearic acid etc., polypeptide class, polysaccharide, polyamines class, containing N compound, collagen protein, growth hormone and auxin, prostaglandin, nucleotide, ganglioside, nerve growth factor, epidermal growth factor and transforming growth factor isoreactivity material; The inorganic constituents containing in Cornu Cervi Pantotrichum mainly contains: 26 kinds of inorganic elementss, comprise the macroelement (Ca, Na, K, P, Mg) of 5 kinds of needed by human and the trace element (Fe, Zn, Cu, Cr, Sr, Ni, Mo, Co, Mn, V, Sn) of 11 kinds of needed by human.Cornu Cervi Pantotrichum is used as the existing thousands of years history of tonic, both can be used for curing the disease, and also can be used for diseases prevention.Compendium of Material Medica is recorded Cornu Cervi Pantotrichum to be had: the effect of " spermatogenesis is mended marrow; tonifying YIN nourishes blood; strong muscles and bones ", tcm clinical practice is mainly used in treating asthenia and wins thin, soreness of waist and knee joint, the sun diseases such as spermatorrhea, deficiency-cold of uterus and bleeding not during menses of continuing, simultaneously also for taking a tonic or nourishing food to build up one's health vigour, increase physical endurance, resisting fatigue, slow down stress, treatment wound and promote childhood development etc.Modern pharmacology experimentation shows, Cornu Cervi Pantotrichum has the immunologic function of enhancing, improves the effects such as sexual function, antioxidation, defying age, promotion wound healing and antitumor.
Penis et testis cervi refers to the external genitalia of male sika deer and Cervus elaphus linnaeus, claims again Penis et testis cervi or deer stem muscle, and " Penis et testis cervi " prefix sees " medical center bun will be visited source ".Modern study and analysis result show, in Flos Mume Penis et testis cervi, containing 22 kinds of mineral elements, 17 kinds of hydrolysis amino acids, 9 kinds of phospholipids compounds, 8 kinds of protein polypeptides, 7 kinds of fatty acids, 4 kinds of hormones, 3 kinds of prostaglandins and 4 kinds of vitamin, abundant chemical composition is the pharmacological basis of Penis et testis cervi performance medical care effect.Penis et testis cervi folk prescription or compatibility Chinese herbal medicine are among the people for kidney invigorating and YANG supporting, and strengthening by means of tonics, regulates nervous function and muscle power, is widely used in treatment various diseases, or makes medicated diet, by dietetic therapy health invigorating, promotion health.
The present invention is taking Transplant Wild Ginseng, Herba Epimedii, sambar's antlers and penis as raw material, through selecting materials, prepare burden, the technique such as cleaning, sterilizing, dry, micropowder, sterilizing, mixing, capsule-filling makes.SHANSHEN flimmer capsule of the present invention has strengthening by means of tonics, kidney invigorating and YANG supporting, physical strength reinforcing and sanatory effect, not yet finds that there is at present taking Transplant Wild Ginseng, Herba Epimedii, sambar's antlers and penis as raw material patented technology and the relevant report of preparation SHANSHEN flimmer capsule.
Summary of the invention:
It is a kind of taking Transplant Wild Ginseng, Herba Epimedii, sambar's antlers and penis as raw material that the object of the invention is to provide, preparation has the SHANSHEN flimmer capsule of strengthening by means of tonics, kidney invigorating and YANG supporting, physical strength reinforcing and promotion health effect, has solved folk prescription and has taken inconvenience and the undesirable shortcoming of effect.
In the present invention, comprise for the preparation of the component of SHANSHEN flimmer capsule: Transplant Wild Ginseng, Herba Epimedii, sambar's antlers and penis.
SHANSHEN flimmer capsule of the present invention, is characterised in that, its processing technology completes according to the following steps:
The 1st step: select materials.Select free from insect pests, go mouldy, the Transplant Wild Ginseng of variable color and other denaturalization phenomenon, Herba Epimedii, sambar's antlers and penis be as raw material.
The 2nd step: batching.Take by weight following raw material:
The 3rd step: clean.Transplant Wild Ginseng can be used manual cleaning, and large-scale processing factory can be used drum type washing ginseng machine, ultrasound wave to wash clean surperficial earth, the dirts of fresh ginseng such as ginseng machine, after cleaning, brushes away reed bowl and supporting root crotch earth with hairbrush.Herba Epimedii, sambar's antlers and penis manual cleaning, then wash off and be still stored in surperficial booty with the sterilized water after filter-sterilized.
The 4th step: dry.In sterilizing room, the moisture evaporation on raw material surface is fallen.
The 5th step: sterilizing.At vertical 1m place, with radiant intensity>=90 μ W/cm
230W ultraviolet disinfection light irradiation 30min, carries out raw material sterilizing.
The 6th step: dry.Raw material uses vacuum freeze drier to be dried, and raw material water content is down to below 13%.Lyophilization is first water-containing materials to be frozen into solid-stately, then makes moisture wherein from the solid-state gaseous state that is directly sublimed into.Because lyophilizing is carried out under low temperature state, can avoid protein and microorganism degeneration or lose activity, can reduce the loss of the nutritional labeling such as effumability and easy heated denaturalization simultaneously.
The 7th step: micropowder.Dried raw material is sent in super micron mill and pulverized respectively, and grinding particle size is 80～120 orders.
The 8th step: sterilizing.Use microwave drying sterilization machine, sterilizing 8 minutes, material thickness 1.0cm.
The 9th step: mix.Raw material after pulverizing is sent into blender mix homogeneously.
The 10th step: fill and fit.Use capsule filling machine filling, then fit, sealing.
The 11st step: capsule, through arranging and polishing → packaging → quality inspection, is finished product.
Beneficial effect of the present invention:
1, antitumor action research
1) materials and methods
Experiment material: with normal saline and the significant Transplant Wild Ginseng of antitumor action in contrast, Transplant Wild Ginseng micropowder and SHANSHEN flimmer compound preparation are provided by Hunchun Huarui and Industry Biological Engineering Co., Ltd., compound preparation is pressed Transplant Wild Ginseng 5.0 weight portions, Herba Epimedii 3.0 weight portions, Cornu Cervi Pantotrichum 1.0 weight portions and Penis et testis cervi 1.0 weight portion preparations, differential granularity 100 orders; Mice transplanted tumor S180, HepA, P388 is purchased from Shanghai Pharmaceutical Inst., Chinese Academy of Sciences; Kunming mouse is bought from Jilin University's animal center, body weight 20 ± 2g, male and female half and half.
Experimental technique: anti-tumor in vivo effect research.Get 60 of mices, 20 every group, inoculate respectively according to a conventional method after 3 kinds of tumor strains, be divided at random 3 groups, dispenser next day.The 1st group of (contrast) equivalent normal saline gavage, the 2nd group of Transplant Wild Ginseng micropowder 3.0gkg
-1gavage, the 3rd group of compound preparation 3.0gkg
-1gavage, 24h administration after inoculation, every day 1 time, 10d continuously, drug withdrawal is weighed next day, gets tumor piece and weighs, and calculates tumour inhibiting rate.
Compound preparation is on S180, HepA, the impact of P388 mouse survival time.Get 60 of mices, divide at random 3 groups, antitumor action research in experimental technique consubstantiality, drug withdrawal next day, observes mice life span record.
The impact of compound preparation on mouse immune organ.Get 60 of mices, divide at random 3 groups, antitumor action research in experimental technique consubstantiality, drug withdrawal next day, gets spleen and thymus is weighed, and then calculates spleen index and thymus index.
2) result
The effect of compound preparation anti-tumor in vivo.From table 1, Transplant Wild Ginseng dosage is 3.0gkg
-1time, mice transplanted tumor S180, HepA and P388 tumour inhibiting rate are respectively to 34.76%, 34.69% and 36.10%, compound preparation dosage is 3.0gkg
-1time, tumour inhibiting rate is respectively 52.41%, 53.57% and 54.15%.Compound preparation and matched group comparison, to mouse tumor growth inhibited, effect reaches utmost point significant level (P < 0.01); With the comparison of Transplant Wild Ginseng group, to mouse tumor growth inhibited, effect reaches significant level (P < 0.05), illustrates that compound preparation antitumor action is better than Transplant Wild Ginseng micropowder.
Table 1 compound preparation is to mouse tumor growth inhibited effect (x ± S)
Note: with compare,
*p < 0.05,
*p < 0.01; With the comparison of Transplant Wild Ginseng group,
▲p < 0.05 (lower same)
Compound preparation is on transplantability S180, HepA, the impact of P388 mouse survival time.From table 2, compound preparation with compare, the prolongation effect of mice life is reached to utmost point significant level (P < 0.01); With the comparison of Transplant Wild Ginseng group, the prolongation effect of mice life is reached to significant level (P < 0.05).
Table 2 compound preparation is on transplantability S180, HepA, the impact of P388 mouse survival time (x ± S)
The impact of compound preparation on immune function of mice organ weight.From table 3, Transplant Wild Ginseng, compound preparation are not remarkable on the impact of mouse immune organ (spleen and thymus) weight, can Immunosuppression function.
The impact (x ± S) of table 3 compound preparation on mouse immune organ weight
2, young mice body weight is increased the research of effect
1) materials and methods
Experiment material: Transplant Wild Ginseng micropowder, Penis et testis cervi micropowder and SHANSHEN flimmer compound preparation are provided by Hunchun Huarui and Industry Biological Engineering Co., Ltd.; Compound preparation is pressed Transplant Wild Ginseng 5.0 weight portions, Herba Epimedii 3.0 weight portions, Cornu Cervi Pantotrichum 1.0 weight portions and Penis et testis cervi 1.0 weight portion preparations, and micropowder granularity is 100 orders; Kunming mouse is bought from Jilin University's animal center, totally 80 of female mices, body weight 8～12g.
Experimental technique: mice is divided into 4 groups at random.25 ° of brewing grains white spirit gavages of the 1st group of (contrast) equivalent, the 2nd group of Transplant Wild Ginseng micropowder 3.0gkg
-1gavage, the 3rd group of Penis et testis cervi micropowder 3.0gkg
-1gavage, the 4th group of compound preparation 3.0gkg
-1gavage, tested rear 16d weighs.
2) result
From table 4, compound preparation group dosage is 3.0gkg
-1time, with matched group comparison, young mice body weight being had and increases extremely significantly effect (P < 0.01), rate of body weight gain is 61.7%, reaches extremely significantly standard; With Transplant Wild Ginseng group and the comparison of Penis et testis cervi group, reach remarkable standard (P < 0.05), illustrate that compound preparation increases effect to young mice body weight and is better than Transplant Wild Ginseng micropowder and Penis et testis cervi micropowder.
Table 4 compound preparation increases effect (x ± S) to the body weight of mice
Note: with compare, * P < 0.05, * * P < 0.01; With Transplant Wild Ginseng and the comparison of Penis et testis cervi group,
▲p < 0.05 (lower same)
3, the research to fasting mouse anti-reflecting fatigue effect
1) materials and methods
Experiment material: Transplant Wild Ginseng micropowder, Penis et testis cervi micropowder and SHANSHEN flimmer compound preparation are provided by Hunchun Huarui and Industry Biological Engineering Co., Ltd., compound preparation is pressed Transplant Wild Ginseng 5.0 weight portions, Herba Epimedii 3.0 weight portions, Cornu Cervi Pantotrichum 1.0 weight portions and Penis et testis cervi 1.0 weight portion preparations, and micropowder granularity is 100 orders; Kunming mouse is bought from Jilin University's animal center.80 of male mices, select body weight 20 ± 2g.
Experimental technique: be divided at random 4 groups, Mus tail load is body weight 10%, each group at tested front average swimming time without significant difference, tested front mice fasting 24h.25 ° of brewing grains white spirit gavages of the 1st group of (contrast) equivalent, the 2nd group of Transplant Wild Ginseng micropowder 3.0gkg
-1gavage, the 3rd group of Penis et testis cervi micropowder 3.0gkg
-1gavage, the 4th group of compound preparation 3.0gkg
-1gavage.Tested rear 1h, puts into depth of water 20cm by mice, in the swimming pool that water temperature is 23 ± 2 DEG C, observes and records mice and start swimming to sinking under water, the unable time of rising to upper punch.
2) result
From table 5, compound preparation group dosage is 3.0gkg
-1time, with matched group comparison, can extend mice swimming time (P < 0.01), rate elongation is 62.2%, reaches extremely significantly standard; With Transplant Wild Ginseng group and the comparison of Penis et testis cervi group, reach remarkable standard (P < 0.05) and illustrate that the effect of compound preparation resisting fatigue is better than Transplant Wild Ginseng micropowder and Penis et testis cervi micropowder.
The resisting fatigue effect (x ± S) of table 5 compound preparation to fasting mice
4, the research of yang invigorating functions
1) impact on castration male rat accessory sex organ
Experiment material: Transplant Wild Ginseng micropowder, Herba Epimedii micropowder, Penis et testis cervi micropowder and SHANSHEN flimmer compound preparation are provided by Hunchun Huarui and Industry Biological Engineering Co., Ltd., compound preparation is pressed Transplant Wild Ginseng 5.0 weight portions, Herba Epimedii 3.0 weight portions, Cornu Cervi Pantotrichum 1.0 weight portions and Penis et testis cervi 1.0 weight portion preparations, and micropowder granularity is 100 orders.SD male rat is bought by Jilin University's animal center.
Experimental technique: 100 of SD male rats, body weight 80～90g, after etherization, under aseptic condition, execute bilateral testes and extract, the conventional antiinflammatory of penicillin, after 3 days, is divided into 5 groups at random, the 1st group (contrast) is equivalent distilled water gavage, the 2nd group of Transplant Wild Ginseng micropowder 3.0gkg
-1gavage, the 3rd group of Herba Epimedii micropowder 3.0gkg
-1gavage, the 4th group of Penis et testis cervi micropowder 3.0gkg
-1gavage, the 5th group of compound preparation 3.0gkg
-1gavage, every day 1 time, continuous 15 days.After last administration 30min, rat is put to death, and win preputial glands, seminal fluid capsule and prostate, then measure organ coefficient.
Result: from table 6, compound preparation group dosage is 3.0gkg
-1time, with matched group comparison, castration male rat accessory sex organ has obvious weightening finish, reaches extremely significantly standard (P < 0.01); With Transplant Wild Ginseng, Herba Epimedii and the comparison of Penis et testis cervi group, reach remarkable standard (P < 0.05), illustrate that compound preparation has obvious effect of gain to castration male rat accessory sex organ, is better than folk prescription processing.
The impact (x ± S) of table 6 on castration male rat accessory sex organ
Note: with compare, * P < 0.05, * * P < 0.01; With Transplant Wild Ginseng, Herba Epimedii and the comparison of Penis et testis cervi group
▲p < 0.05
2) impact on mating ability
Experiment material: Transplant Wild Ginseng micropowder, Herba Epimedii micropowder, Penis et testis cervi micropowder and SHANSHEN flimmer compound preparation are provided by Hunchun Huarui and Industry Biological Engineering Co., Ltd., compound preparation is pressed Transplant Wild Ginseng 5.0 weight portions, Herba Epimedii 3.0 weight portions, Cornu Cervi Pantotrichum 1.0 weight portions and Penis et testis cervi 1.0 weight portion preparations, and micropowder granularity is 100 orders.SD rat is bought by Jilin University's animal center.
Experimental technique: 100 of SD female rats, body weight 240～260g, executes bilateral ovaries enucleation, the conventional antiinflammatory of penicillin 3 days, before copulation, only, first 4h subcutaneous injection progesterone injection 500mg/ of copulation, for copulation for 48h subcutaneous injection estradiol benzoate 20ng/.
100 of SD female rats, are divided into 5 groups at random, and the 1st group (contrast) is equivalent distilled water gavage, the 2nd group of Transplant Wild Ginseng micropowder 3.0gkg
-1gavage, the 3rd group of Herba Epimedii micropowder 3.0gkg
-1gavage, the 4th group of Penis et testis cervi micropowder 3.0gkg
-1gavage, the 5th group of compound preparation 3.0gkg
-1gavage, every day 1 time, continuous 30 days.After last administration 30min, female rats is put into separately to 40cm × 30cm × 20cm cage, after 5min, put into 1 of female rats, observed and recorded female rats is flutterred and is caught flutterring for the first time in the time of catching and 20min of female rats and flutter and catch number of times.
Result: from table 7, compound preparation group dosage is 3.0gkg
-1time, take continuously SHANSHEN flimmer compound preparation 30 days, with matched group comparison, mating ability obviously improves, and flutters to catch and obviously shortens incubation period, flutters to catch number of times and obviously increase, and reaches extremely significantly standard (P < 0.01); With Transplant Wild Ginseng, Herba Epimedii and the comparison of Penis et testis cervi group, reach remarkable standard (P < 0.05), illustrate that the mating ability of compound preparation is better than folk prescription processing.
The impact (x ± S) of table 7 on mating ability
| Group | Flutter and catch incubation period (min) | Flutter and catch number of times (inferior/20min) |
| Contrast | 18.6±3.2 | 1.3±1.5 |
| Transplant Wild Ginseng | 15.8±4.7 | 2.8±3.1 |
| Herba Epimedii | 16.3±2.8 | 3.4±1.9 |
| Penis et testis cervi | 11.5±3.6* | 6.4±2.8* |
| Compound preparation | 8.6±2.4** ▲ | 7.2±4.5** ▲ |
Note: with compare, * P < 0.05, * * P < 0.01; With Transplant Wild Ginseng, Herba Epimedii and the comparison of Penis et testis cervi group,
▲p < 0.05
Detailed description of the invention:
Embodiments of the invention only, for embodiments of the present invention are described, do not limit practical range of the present invention.
The 1st step: select materials.Select free from insect pests, go mouldy, the Transplant Wild Ginseng of variable color and other denaturalization phenomenons, Herba Epimedii, sambar's antlers and penis be as raw material.
The 2nd step: batching.Take by weight following raw material: Transplant Wild Ginseng 4.0～6.0 weight portions, excessive sheep flower bud 2.0～4.0 weight portions, Cornu Cervi Pantotrichum 0.5～1.5 weight portion and Penis et testis cervi 0.5～1.5 weight portion.
The 3rd step: clean.Transplant Wild Ginseng can be used manual cleaning, and large-scale processing factory can be used drum type washing ginseng machine, ultrasound wave to wash the clean surperficial earth of fresh ginseng, the dirts such as ginseng machine, after cleaning, brushes away reed bowl and supporting root fork place earth with hairbrush.Herba Epimedii, sambar's antlers and penis manual cleaning, then wash off and be still stored in surperficial booty with the sterilized water after filter-sterilized.
The 4th step: dry.In sterilizing room, the moisture evaporation on raw material surface is fallen.
The 5th step: sterilizing.At vertical 1m place, with radiant intensity>=90 μ W/cm
230W ultraviolet sterilization light irradiation 30min, carries out raw material sterilizing.
The 6th step: dry.Raw material uses vacuum freeze drier to be dried, and raw material water content is down to below 13%.
The 7th step: micropowder.Dried raw material is sent in super micron mill and pulverized respectively, and grinding particle size is 80～120 orders.
The 8th step: sterilizing.Use microwave in dry sterilization machine, sterilizing 8 minutes, material thickness 1.0cm.
The 9th step: mix.Raw material after pulverizing is sent into blender mix homogeneously.
The 10th step: fill and fit.Use capsule filling machine filling, then fit, sealing.
The 11st step: capsule, through arranging and polishing → packaging → quality inspection, is finished product.
Embodiment
The 1st step: select materials.Select free from insect pests, go mouldy, the Transplant Wild Ginseng of variable color and other denaturalization phenomenons, Herba Epimedii, sambar's antlers and penis be as raw material.
The 2nd step: batching.Take by weight following raw material: Transplant Wild Ginseng 50.0Kg, Herba Epimedii 30.0Kg, Cornu Cervi Pantotrichum 10.0Kg and Penis et testis cervi 10.0Kg, total amount 100.0Kg.
The 3rd step: clean.Transplant Wild Ginseng can be used manual cleaning, and large-scale processing factory can be used drum type washing ginseng machine, ultrasound wave to wash the clean surperficial earth of fresh ginseng, the dirts such as ginseng machine, after cleaning, brushes away reed bowl and supporting root fork place earth with hairbrush.Herba Epimedii, sambar's antlers and penis manual cleaning, then wash off and be still stored in surperficial booty with the sterilized water after filter-sterilized.
The 4th step: dry.In sterilizing room, the moisture evaporation on raw material surface is fallen.
The 5th step: sterilizing.At vertical 1m place, with radiant intensity>=90 μ W/cm
230W ultraviolet sterilization light irradiation 30min, carries out raw material sterilizing.
The 6th step: dry.Raw material uses vacuum freeze drier to be dried, and raw material water content is down to below 13%.
The 7th step: micropowder.Dried raw material is sent in super micron mill and pulverized respectively, and grinding particle size is 80～120 orders.
The 8th step: sterilizing.Use microwave drying sterilization machine, sterilizing 8 minutes, material thickness 1.0cm.
The 9th step: mix.Raw material after pulverizing is sent into blender mix homogeneously.
The 10th step: fill and fit.Use capsule filling machine filling, then fit, sealing.
The 11st step: capsule, through arranging and polishing → packaging → quality inspection, is finished product.
Using method: the present invention is specially adapted to immunocompromised person and fatiguability person, 3 days 1 time, each 2～4; Anemia of pregnant woman, child and hyperpietic are unsuitable.
Claims (5)
1. a SHANSHEN flimmer capsule, is characterized in that:
Made by following raw material by weight: Transplant Wild Ginseng 4.0～6.0, Herba Epimedii 2.0～4.0, Cornu Cervi Pantotrichum 0.5～1.5, Penis et testis cervi 0.5～1.5.
2. SHANSHEN flimmer capsule according to claim 1, is characterized in that prepared SHANSHEN flimmer capsule has antineoplastic action.
3. SHANSHEN flimmer capsule according to claim 1, is characterized in that prepared SHANSHEN flimmer capsule has the effect of putting on weight.
4. SHANSHEN flimmer capsule according to claim 1, is characterized in that prepared SHANSHEN flimmer capsule has the effect of resisting fatigue.
5. SHANSHEN flimmer capsule according to claim 1, is characterized in that prepared SHANSHEN flimmer capsule has the effect of tonifying YANG.
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| CN1539460A (en) * | 2003-10-30 | 2004-10-27 | 吉林省辽源亚东药业股份有限公司 | Chinese materia medica preparation of prolonging life for invigorating the kidney yang and producing method |
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