CN102264694B - 用于制备伏立诺他的方法 - Google Patents

用于制备伏立诺他的方法 Download PDF

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Publication number
CN102264694B
CN102264694B CN200980150218.2A CN200980150218A CN102264694B CN 102264694 B CN102264694 B CN 102264694B CN 200980150218 A CN200980150218 A CN 200980150218A CN 102264694 B CN102264694 B CN 102264694B
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China
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coupling agent
cdi
following
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carried out
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CN200980150218.2A
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English (en)
Chinese (zh)
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CN102264694A (zh
Inventor
维纳亚克·G·戈雷
马杜卡尔·S·帕蒂尔
拉胡尔·A·巴勒拉奥
赫曼特·M·曼德
桑迪普·G·梅克德
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Generics UK Ltd
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Generics UK Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200980150218.2A 2008-10-15 2009-10-14 用于制备伏立诺他的方法 Expired - Fee Related CN102264694B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1746/KOL/2008 2008-10-15
IN1746KO2008 2008-10-15
PCT/GB2009/051376 WO2010043904A2 (en) 2008-10-15 2009-10-14 Improved process

Publications (2)

Publication Number Publication Date
CN102264694A CN102264694A (zh) 2011-11-30
CN102264694B true CN102264694B (zh) 2015-11-25

Family

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Family Applications (1)

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CN200980150218.2A Expired - Fee Related CN102264694B (zh) 2008-10-15 2009-10-14 用于制备伏立诺他的方法

Country Status (8)

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US (2) US8883851B2 (enExample)
EP (1) EP2349985A2 (enExample)
JP (1) JP5769627B2 (enExample)
CN (1) CN102264694B (enExample)
AU (1) AU2009305214B2 (enExample)
CA (1) CA2740559C (enExample)
NZ (1) NZ592686A (enExample)
WO (1) WO2010043904A2 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1391812B1 (it) * 2008-07-29 2012-01-27 Maria Grazia Rimoli Profarmaco galattosilato del ketorolac ad uso analgesico e antinfiammatorio con migliori caratteristiche farmacocinetiche e profilo tossicologico del farmaco di partenza
AU2009321384A1 (en) 2008-11-26 2011-06-23 Generics [Uk] Limited Polymorphs
WO2011061545A1 (en) 2009-11-23 2011-05-26 Generics [Uk] Limited Hplc method for analyzing vorinostat
US20110313044A1 (en) * 2010-06-18 2011-12-22 Urquima S.A. Polymorphs of Suberoylanilide Hydroxamic Acid
CN103018346A (zh) * 2011-09-20 2013-04-03 北京本草天源药物研究院 伏立诺他及其药物组合物中的杂质的高效液相色谱分析方法
CN104693071A (zh) * 2013-12-04 2015-06-10 山东新时代药业有限公司 一种n- 羟基-n’- 苯基辛二酰胺制备方法
CN103922967B (zh) * 2014-04-15 2016-06-01 北京化工大学 一种异羟肟酸类化合物及其在制备抑制癌细胞增殖和/或治疗癌症的药物中的应用
CN104292133B (zh) * 2014-09-29 2016-06-01 烟台市华文欣欣医药科技有限公司 一种抗癌药物伏立诺他的合成方法
CN104649925A (zh) * 2015-02-13 2015-05-27 山东新时代药业有限公司 一种伏立诺他中间体的制备方法
CN105259261A (zh) * 2015-10-09 2016-01-20 扬子江药业集团江苏海慈生物药业有限公司 一种药物中苯胺含量的测定方法
CN106008267B (zh) * 2016-06-27 2018-04-06 马腾 一种抗癌药物伏立诺他的制备方法
CN106187818B (zh) * 2016-06-27 2017-12-08 刘美新 一种制备抗癌药物伏立诺他的方法
US11554123B2 (en) * 2017-03-01 2023-01-17 Saint Joseph's University Compositions and methods for reactivating latent HIV-1 infections
TWI650139B (zh) 2017-10-11 2019-02-11 行政院原子能委員會核能硏究所 含有放射性同位素氟的異羥肟酸類造影劑、其製備方法及其用途
CN109134313B (zh) * 2018-10-16 2021-05-25 新昌县勤勉生物医药科技有限公司 一种利用改性介孔材料催化制备伏立诺他的方法
CN110283102B (zh) * 2019-05-31 2022-09-27 宿州亿帆药业有限公司 一种伏林司他ⅰ晶型的制备方法
CN113943232A (zh) * 2021-11-25 2022-01-18 汤斌 一种从大鲵肽中提取伏立诺他的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1870985A (zh) * 2003-08-26 2006-11-29 阿托恩药品公司 用hdac抑制剂治疗癌症的方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5369108A (en) * 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
GB9504084D0 (en) * 1995-03-01 1995-04-19 British Biotech Pharm Synthesis of carboxylic and hydroxamic acid derivatives
IT1283637B1 (it) * 1996-05-14 1998-04-23 Italfarmaco Spa Composti ad attivita' antinfiammatoria ed immunosoppressiva
US6497820B1 (en) 1998-02-03 2002-12-24 Arqule, Inc. Rapid method for separation of small molecules using reverse phase high performance liquid chromatography
US6541661B1 (en) * 1999-11-23 2003-04-01 Methylgene, Inc. Inhibitors of histone deacetylase
US7456219B2 (en) * 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
EP2322160A1 (en) 2002-03-04 2011-05-18 Merck HDAC Research, LLC Methods of inducing terminal differentiation
PT1663194E (pt) 2003-08-26 2010-07-06 Merck Hdac Res Llc Utilizaã†o de saha para o tratamento de mesotelioma
EP1541549A1 (en) 2003-12-12 2005-06-15 Exonhit Therapeutics S.A. Tricyclic hydroxamate and benzaminde derivatives, compositions and methods
RU2354362C2 (ru) 2005-05-20 2009-05-10 Мерк Энд Ко., Инк. Композиции субероиланилид-гидроксаминовой кислоты и способы их получения
TWI415603B (zh) * 2005-05-20 2013-11-21 Merck Sharp & Dohme １，８－辛二醯基苯胺羥胺酸（ｓｕｂｅｒｏｙｌａｎｉｌｉｄｅ ｈｙｄｒｏｘａｍｉｃ ａｃｉｄ）之調配物及其製配方法
JP2010504969A (ja) 2006-09-28 2010-02-18 メルク エンド カムパニー インコーポレーテッド Ｓａｈａのアミン塩基塩及びその多形
MX2009003405A (es) 2006-09-28 2009-04-09 Merck & Co Inc Composiciones farmaceuticas de inhibidores de la histona desacetilasa y compuestos quelantes de metal, y complejos de quelato de metal-inhibidor de histona desacetilasa.
US20110041589A1 (en) 2007-12-14 2011-02-24 Generics [Uk] Limited New hpcl method
WO2009098515A1 (en) * 2008-02-07 2009-08-13 Generics [Uk] Limited Novel process for the preparation of vorinostat
US20090223286A1 (en) 2008-02-13 2009-09-10 Vandana Singh Analytical method for determination of related substances of imipenem and cilastatin
CZ2008167A3 (cs) 2008-03-14 2010-02-24 Zentiva, A. S. Specifické necistoty montelukastu
AU2009321384A1 (en) 2008-11-26 2011-06-23 Generics [Uk] Limited Polymorphs
US20110269838A1 (en) 2008-11-26 2011-11-03 Vinayak Gore Novel processes and pure polymorphs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1870985A (zh) * 2003-08-26 2006-11-29 阿托恩药品公司 用hdac抑制剂治疗癌症的方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A NEW FACILE AND EXPEDITIOUS SYNTHESIS OF N-HYDROXY-A’-PHENYLOCTANEDIAMJDAE ,P OTENT INDUCER OF TERMINAL CYTODIFFERECNTIATION;Mai Antonello et al.;《Organic Preparation and Procedures》;20011231;第33卷(第4期);391-394 *
A New Simple and High-Yield Synthesis of Suberoylanilide Hydroxamic Acid and Its Inhibitory Effect Alone or in Combination with Retinoids on Proliferation of Human Prostate Cancer Cells;Lalji K. Gediya et al.;《Journal of Medicinal Chemistry》;20050625;第48卷(第15期);5047-5051 *
The Synthesis of N-Hydroxy-N’-phenyloctanediamide and Its Inhibitory Effect on Proliferation of AXC Rat Prostate Cancer Cells;John C. Stowell et al.;《Journal of Medicinal Chemistry》;19951231;第38卷(第8期);1411-1413 *

Also Published As

Publication number Publication date
NZ592686A (en) 2012-12-21
JP2012505872A (ja) 2012-03-08
US9162974B2 (en) 2015-10-20
WO2010043904A3 (en) 2010-09-16
AU2009305214A1 (en) 2010-04-22
CN102264694A (zh) 2011-11-30
US20150018424A1 (en) 2015-01-15
EP2349985A2 (en) 2011-08-03
US20110263712A1 (en) 2011-10-27
JP5769627B2 (ja) 2015-08-26
CA2740559A1 (en) 2010-04-22
CA2740559C (en) 2016-02-16
WO2010043904A2 (en) 2010-04-22
US8883851B2 (en) 2014-11-11
AU2009305214B2 (en) 2015-06-25

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