CN102245202A - 含有突变型h因子结合蛋白的疫苗组合物 - Google Patents

含有突变型h因子结合蛋白的疫苗组合物 Download PDF

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Publication number
CN102245202A
CN102245202A CN2009801480003A CN200980148000A CN102245202A CN 102245202 A CN102245202 A CN 102245202A CN 2009801480003 A CN2009801480003 A CN 2009801480003A CN 200980148000 A CN200980148000 A CN 200980148000A CN 102245202 A CN102245202 A CN 102245202A
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China
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factor
composition
binding protein
immune response
human
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CN2009801480003A
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English (en)
Chinese (zh)
Inventor
R·埃克斯利
C·唐
S·M·利亚
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Ip2ipo Innovations Ltd
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Imperial Innovations Ltd
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Priority to CN201510119007.XA priority Critical patent/CN105412920A/zh
Publication of CN102245202A publication Critical patent/CN102245202A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2009801480003A 2008-10-25 2009-10-26 含有突变型h因子结合蛋白的疫苗组合物 Pending CN102245202A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510119007.XA CN105412920A (zh) 2008-10-25 2009-10-26 含有突变型ｈ因子结合蛋白的疫苗组合物

Applications Claiming Priority (3)

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GBGB0819633.9A GB0819633D0 (en) 2008-10-25 2008-10-25 Composition
GB0819633.9 2008-10-25
PCT/GB2009/051439 WO2010046715A1 (en) 2008-10-25 2009-10-26 Vaccine compositions comprising a mutated factor h binding protein

Related Child Applications (1)

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CN201510119007.XA Division CN105412920A (zh) 2008-10-25 2009-10-26 含有突变型ｈ因子结合蛋白的疫苗组合物

Publications (1)

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CN102245202A true CN102245202A (zh) 2011-11-16

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CN2009801480003A Pending CN102245202A (zh) 2008-10-25 2009-10-26 含有突变型h因子结合蛋白的疫苗组合物
CN201510119007.XA Pending CN105412920A (zh) 2008-10-25 2009-10-26 含有突变型ｈ因子结合蛋白的疫苗组合物

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Country Link
US (1) US20120052092A1 (cg-RX-API-DMAC7.html)
EP (2) EP3501534B1 (cg-RX-API-DMAC7.html)
JP (2) JP5676458B2 (cg-RX-API-DMAC7.html)
KR (3) KR20170000390A (cg-RX-API-DMAC7.html)
CN (2) CN102245202A (cg-RX-API-DMAC7.html)
AU (1) AU2009306114B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0919926A2 (cg-RX-API-DMAC7.html)
CA (1) CA2741619A1 (cg-RX-API-DMAC7.html)
CO (1) CO6382140A2 (cg-RX-API-DMAC7.html)
DK (1) DK3501534T5 (cg-RX-API-DMAC7.html)
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HR (1) HRP20240226T1 (cg-RX-API-DMAC7.html)
HU (1) HUE065348T2 (cg-RX-API-DMAC7.html)
LT (1) LT3501534T (cg-RX-API-DMAC7.html)
MX (1) MX2011004322A (cg-RX-API-DMAC7.html)
NZ (2) NZ592444A (cg-RX-API-DMAC7.html)
PL (1) PL3501534T3 (cg-RX-API-DMAC7.html)
PT (1) PT3501534T (cg-RX-API-DMAC7.html)
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Cited By (1)

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CN107074939A (zh) * 2014-08-20 2017-08-18 桑昆血液供给基金会 H因子增强抗体及其用途

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EP1179072A2 (en) 1999-05-19 2002-02-13 Chiron S.P.A. Combination neisserial compositions
PT2275551E (pt) 1999-10-29 2015-06-29 Novartis Vaccines & Diagnostic Péptidos antigénicos de neisseria
PT2270030E (pt) 2000-02-28 2012-07-24 Novartis Vaccines & Diagnostic Expressão heteróloga de proteínas de neisseria
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
EP2351579B1 (en) 2002-10-11 2016-09-21 Novartis Vaccines and Diagnostics S.r.l. Polypeptide vaccines for broad protection against hypervirulent meningococcal lineages
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
AU2009215364B2 (en) 2008-02-21 2014-09-18 Glaxosmithkline Biologicals S.A. Meningococcal fHBP polypeptides
AU2009223613B2 (en) 2008-03-10 2014-09-25 Children's Hospital & Research Center At Oakland Chimeric factor H binding proteins (fHBP) containing a heterologous B domain and methods of use
CN104548082A (zh) 2009-03-24 2015-04-29 诺华股份有限公司 为脑膜炎球菌因子h结合蛋白添加佐剂
US9266942B2 (en) 2009-04-30 2016-02-23 Children's Hospital & Research Center Oakland Chimeric factor H binding proteins (fHbp) and methods of use
CA2779816A1 (en) 2009-10-27 2011-05-05 Novartis Ag Modified meningococcal fhbp polypeptides
EP2544714A1 (en) * 2010-03-10 2013-01-16 GlaxoSmithKline Biologicals S.A. Vaccine composition
TR201802933T4 (tr) * 2010-03-30 2018-03-21 Childrens Hospital & Res Center At Oakland Özellikleri değiştirilmiş faktör h bağlama proteinleri (fhbp) ve bunların kullanım yöntemi.
WO2011161653A1 (en) 2010-06-25 2011-12-29 Novartis Ag Combinations of meningococcal factor h binding proteins
MX2014008988A (es) 2012-02-02 2014-08-27 Novartis Ag Promotores para aumento de expresion de proteinas en meningococo.
ES2847923T3 (es) 2012-06-14 2021-08-04 Glaxosmithkline Biologicals Sa Vacunas contra el meningococo del serogrupo X
CN104736563A (zh) 2012-07-27 2015-06-24 国家健康与医学研究院 Cd147作为受体用于脑膜炎球菌至血管内皮的菌毛介导的粘附
US20160030544A1 (en) * 2013-03-14 2016-02-04 Isis Innovation Limited Immunogenic composition to neisseria
WO2015017817A1 (en) 2013-08-02 2015-02-05 Children's Hospital & Research Center Oakland Non-naturally occurring factor h binding proteins (fhbp) and methods of use thereof
CN106661092B (zh) 2014-02-28 2021-07-06 葛兰素史密丝克莱恩生物有限公司 修饰的脑膜炎球菌fHbp多肽
BR112017001417B1 (pt) 2014-07-23 2023-11-07 Children's Hospital & Research Center At Oakland Variantes da proteína de ligação ao fator h (fhbp), composição imunogênica e uso de uma fhbp variante referência cruzada
GB201614687D0 (en) * 2016-08-31 2016-10-12 Univ Oxford Innovation Ltd fHbp scaffold
EP3607967A1 (en) 2018-08-09 2020-02-12 GlaxoSmithKline Biologicals S.A. Modified meningococcal fhbp polypeptides
EP3897706A4 (en) 2018-12-21 2022-11-23 Griffith University COMPOSITIONS, METHODS AND USES FOR INDURING AN IMMUNE RESPONSE
AU2020309556A1 (en) * 2019-07-08 2022-03-03 Crapaud Bio, Inc. Methods of making and using lipooligosaccharide compositions and vaccines
JP7631296B2 (ja) 2019-07-17 2025-02-18 ジェミニ・セラピューティクス・サブ・インコーポレイテッド Ｈ因子増強性抗体及びその使用
TW202245836A (zh) 2021-02-19 2022-12-01 美商賽諾菲巴斯德公司 重組ｂ型腦膜炎球菌疫苗
TW202423477A (zh) 2022-08-03 2024-06-16 美商賽諾菲巴斯德公司 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107074939A (zh) * 2014-08-20 2017-08-18 桑昆血液供给基金会 H因子增强抗体及其用途
CN107074939B (zh) * 2014-08-20 2021-09-07 桑昆血液供给基金会 H因子增强抗体及其用途

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Publication number Publication date
SI3501534T1 (sl) 2024-03-29
AU2009306114B2 (en) 2015-10-01
BRPI0919926A2 (pt) 2016-02-16
KR20110092282A (ko) 2011-08-17
AU2009306114A1 (en) 2010-04-29
RU2559528C2 (ru) 2015-08-10
EP3501534A1 (en) 2019-06-26
DK3501534T3 (da) 2024-02-05
ES2970878T3 (es) 2024-05-31
CA2741619A1 (en) 2010-04-29
KR20170000390A (ko) 2017-01-02
HUE065348T2 (hu) 2024-05-28
PL3501534T3 (pl) 2024-04-02
PT3501534T (pt) 2024-02-07
JP6076326B2 (ja) 2017-02-08
EP3501534B1 (en) 2023-11-29
LT3501534T (lt) 2024-03-12
JP5676458B2 (ja) 2015-02-25
MX2011004322A (es) 2011-06-16
JP2012506411A (ja) 2012-03-15
EP2355845B1 (en) 2018-12-05
CO6382140A2 (es) 2012-02-15
NZ601538A (en) 2014-01-31
US20120052092A1 (en) 2012-03-01
KR20190011836A (ko) 2019-02-07
GB0819633D0 (en) 2008-12-03
WO2010046715A1 (en) 2010-04-29
EP2355845A1 (en) 2011-08-17
HRP20240226T1 (hr) 2024-05-10
JP2015063558A (ja) 2015-04-09
CN105412920A (zh) 2016-03-23
FI3501534T3 (fi) 2024-02-09
RU2011120706A (ru) 2012-11-27
DK3501534T5 (da) 2024-09-02
NZ592444A (en) 2012-11-30

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