CN102231979B - 基因沉默治疗剂的脂质体有效递送方法和组合物 - Google Patents

基因沉默治疗剂的脂质体有效递送方法和组合物 Download PDF

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CN102231979B
CN102231979B CN200980148321.3A CN200980148321A CN102231979B CN 102231979 B CN102231979 B CN 102231979B CN 200980148321 A CN200980148321 A CN 200980148321A CN 102231979 B CN102231979 B CN 102231979B
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alkyl
compositions
liposome
amino acid
rna
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CN102231979A (zh
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巴里·A·波利斯基
罗格·C·阿达米
迈克尔·V·滕普林
皮埃罗·哈维
雷切尔·E·约翰斯
贾亚·S·吉亚纳尼
迈克尔·E·休斯顿
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Marina Biotech Inc
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    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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CN200980148321.3A 2008-10-16 2009-10-16 基因沉默治疗剂的脂质体有效递送方法和组合物 Expired - Fee Related CN102231979B (zh)

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US10606208P 2008-10-16 2008-10-16
US61/106,062 2008-10-16
US16737909P 2009-04-07 2009-04-07
US61/167,379 2009-04-07
PCT/US2009/060930 WO2010045512A2 (en) 2008-10-16 2009-10-16 Processes and compositions for liposomal and efficient delivery of gene silencing therapeutics

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CN201410524574.9A Division CN104382853A (zh) 2008-10-16 2009-10-16 基因沉默治疗剂的脂质体有效递送方法和组合物

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CN102231979A CN102231979A (zh) 2011-11-02
CN102231979B true CN102231979B (zh) 2014-10-29

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CN201410524574.9A Pending CN104382853A (zh) 2008-10-16 2009-10-16 基因沉默治疗剂的脂质体有效递送方法和组合物

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US (3) US20100112042A1 (enExample)
EP (2) EP2349210B1 (enExample)
JP (2) JP2012505913A (enExample)
KR (1) KR20110071017A (enExample)
CN (2) CN102231979B (enExample)
AU (3) AU2009305639B2 (enExample)
BR (1) BRPI0920171A2 (enExample)
CA (1) CA2739046A1 (enExample)
IL (1) IL212329A0 (enExample)
SG (1) SG196818A1 (enExample)
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