CN102227432B - 制备二氢卟酚的方法及它们的医药用途 - Google Patents

制备二氢卟酚的方法及它们的医药用途 Download PDF

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Publication number
CN102227432B
CN102227432B CN200980147426.7A CN200980147426A CN102227432B CN 102227432 B CN102227432 B CN 102227432B CN 200980147426 A CN200980147426 A CN 200980147426A CN 102227432 B CN102227432 B CN 102227432B
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luzitin
cells
light
laser
carbon
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Expired - Fee Related
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CN200980147426.7A
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English (en)
Chinese (zh)
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CN102227432A (zh
Inventor
L·G·达西尔瓦阿诺特莫雷拉
M·梅古恩斯派雷拉
S·J·弗莫辛豪桑切斯希莫斯
S·P·玛加尔黑斯希莫斯
K·厄班斯卡
G·斯图彻尔
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BLUEPHARMA IND FARMACEUTICA S
Universidade de Coimbra
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BLUEPHARMA IND FARMACEUTICA S
Universidade de Coimbra
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
CN200980147426.7A 2008-10-24 2009-10-22 制备二氢卟酚的方法及它们的医药用途 Expired - Fee Related CN102227432B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0819594.3A GB0819594D0 (en) 2008-10-24 2008-10-24 Process
GB0819594.3 2008-10-24
PCT/PT2009/000057 WO2010047611A1 (en) 2008-10-24 2009-10-22 Process for preparing chlorins and their pharmaceutical uses

Publications (2)

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CN102227432A CN102227432A (zh) 2011-10-26
CN102227432B true CN102227432B (zh) 2015-04-22

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CN200980147426.7A Expired - Fee Related CN102227432B (zh) 2008-10-24 2009-10-22 制备二氢卟酚的方法及它们的医药用途

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US (1) US9670217B2 (enExample)
EP (1) EP2346874B1 (enExample)
JP (1) JP5567024B2 (enExample)
CN (1) CN102227432B (enExample)
AU (1) AU2009307106B2 (enExample)
BR (1) BRPI0919868B8 (enExample)
CA (1) CA2741429C (enExample)
DK (1) DK2346874T3 (enExample)
ES (1) ES2450136T3 (enExample)
GB (1) GB0819594D0 (enExample)
PL (1) PL2346874T3 (enExample)
PT (1) PT2346874E (enExample)
RU (1) RU2513483C2 (enExample)
WO (1) WO2010047611A1 (enExample)
ZA (1) ZA201102760B (enExample)

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CN107427580B (zh) * 2015-03-20 2020-11-17 卢西蒂恩股份有限公司 卤代四苯基细菌卟吩和二氢卟吩的阻转异构体及它们在光动力学疗法中的应用
HK1245254A1 (zh) * 2015-05-07 2018-08-24 卢西蒂恩股份有限公司 甲酰胺卤化的卟啉的低分子量衍生物、即二氢卟酚和菌绿素及其应用
WO2017027247A1 (en) 2015-08-07 2017-02-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Near infrared photoimmunotherapy (nir-pit) of suppressor cells to treat cancer
CN119564879A (zh) 2015-08-18 2025-03-07 乐天医药生技股份有限公司 用于光免疫疗法的组合物、联用及相关方法
AU2016308286B2 (en) 2015-08-18 2022-04-07 Rakuten Medical, Inc. Phthalocyanine dye conjugates and their storage
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WO2018216679A1 (ja) * 2017-05-22 2018-11-29 国立大学法人京都大学 テトラフェニルポルフィリン誘導体
WO2019067523A1 (en) * 2017-09-29 2019-04-04 Duke University FLUOROSUBSTITUTED PORPHYRIN COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF PREPARATION AND USE THEREOF
AU2019276572B2 (en) 2018-06-01 2024-11-21 Rakuten Medical, Inc. Phthalocyanine dye conjugate compositions
CN109912607B (zh) * 2018-12-11 2021-01-22 南华大学 一类卟啉-白杨素复合物及其抗肿瘤活性
CN109651383B (zh) * 2019-01-25 2021-11-16 华东理工大学 用于光敏剂的化合物及其应用
JP7754724B2 (ja) * 2019-05-20 2025-10-15 ニルバナ サイエンシーズ インク． 発光波長の範囲が狭い発光染料、それを含む組成物及びそれを製造及び使用する方法
RU2725876C1 (ru) * 2019-07-15 2020-07-07 Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) Производные фторсодержащих хлоринов, проявляющие противоопухолевую активность
CN114504551B (zh) * 2020-11-16 2024-01-02 北京厚燊维康科技有限责任公司 可用于光动力治疗或诊断的制剂
RU2759743C2 (ru) * 2021-04-14 2021-11-17 Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации (ФГБУ «НМИЦ радиологии» Минздрава России) Способ комбинированного лечения локализованного t1-t2n0m0 рака гортани
JPWO2023022187A1 (enExample) * 2021-08-18 2023-02-23
MY208934A (en) * 2021-10-06 2025-06-12 Tunku Abdul Rahman Univ Of Management And Technology Tar Umt Treating skin diseases using a photodynamic therapy (pdt) and a topical agent photosensitizer formulation
CN114813592A (zh) * 2022-03-11 2022-07-29 华南理工大学 一种探究羟基氯喹在自然水体中降解机理的方法
CN114870011B (zh) * 2022-03-24 2023-06-06 深圳大学 一种增强实体瘤内原卟啉ix蓄积的微针贴片及其制备方法
CN119751254B (zh) * 2025-01-13 2025-11-28 浙江工业大学 一种光催化氧化甲烷制备三氟乙酸甲酯的方法

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WO2008102669A1 (ja) * 2007-02-19 2008-08-28 Rei Medical Co., Ltd. 新規な糖連結クロリン誘導体及びその製造方法

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CN1549729A (zh) * 2001-08-30 2004-11-24 Pci���＼����˾ 化合物
WO2006053707A1 (fr) * 2004-11-16 2006-05-26 Universidade De Coimbra Nouveaux derives de porphyrine, notamment chlorines et/ou bacteriochlorines et leurs applications en therapie photodynamique
CN101102766A (zh) * 2004-11-16 2008-01-09 科英布拉大学 新型卟啉衍生物，尤其二氢卟酚和/或菌绿素及其在光动力学治疗中的应用
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Also Published As

Publication number Publication date
WO2010047611A1 (en) 2010-04-29
EP2346874A1 (en) 2011-07-27
ZA201102760B (en) 2012-07-25
JP2012506425A (ja) 2012-03-15
RU2011114878A (ru) 2012-11-27
BRPI0919868B8 (pt) 2021-05-25
ES2450136T3 (es) 2014-03-24
PT2346874E (pt) 2014-03-06
AU2009307106A1 (en) 2010-04-29
CA2741429A1 (en) 2011-04-29
DK2346874T3 (en) 2014-03-03
GB0819594D0 (en) 2008-12-03
CA2741429C (en) 2017-04-18
JP5567024B2 (ja) 2014-08-06
BRPI0919868B1 (pt) 2020-10-27
RU2513483C2 (ru) 2014-04-20
BRPI0919868A2 (pt) 2015-12-15
AU2009307106B2 (en) 2015-05-07
PL2346874T3 (pl) 2014-05-30
WO2010047611A9 (en) 2010-07-22
CN102227432A (zh) 2011-10-26
EP2346874B1 (en) 2013-12-04
US20110250143A1 (en) 2011-10-13
US9670217B2 (en) 2017-06-06
HK1160848A1 (en) 2012-08-17

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