CN102209541B - 醛脱氢酶活性调节剂和其使用方法 - Google Patents

醛脱氢酶活性调节剂和其使用方法 Download PDF

Info

Publication number
CN102209541B
CN102209541B CN200980144866.7A CN200980144866A CN102209541B CN 102209541 B CN102209541 B CN 102209541B CN 200980144866 A CN200980144866 A CN 200980144866A CN 102209541 B CN102209541 B CN 102209541B
Authority
CN
China
Prior art keywords
aldh
replace
alkyl
formula
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980144866.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN102209541A (zh
Inventor
W·杨
C-H·陈
D·默克利-罗森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of CN102209541A publication Critical patent/CN102209541A/zh
Application granted granted Critical
Publication of CN102209541B publication Critical patent/CN102209541B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200980144866.7A 2008-09-08 2009-09-03 醛脱氢酶活性调节剂和其使用方法 Expired - Fee Related CN102209541B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9522708P 2008-09-08 2008-09-08
US61/095,227 2008-09-08
PCT/US2009/055927 WO2010028175A1 (en) 2008-09-08 2009-09-03 Modulators of aldehyde dehydrogenase activity and methods of use thereof

Publications (2)

Publication Number Publication Date
CN102209541A CN102209541A (zh) 2011-10-05
CN102209541B true CN102209541B (zh) 2016-05-18

Family

ID=41797485

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980144866.7A Expired - Fee Related CN102209541B (zh) 2008-09-08 2009-09-03 醛脱氢酶活性调节剂和其使用方法

Country Status (7)

Country Link
US (3) US8354435B2 (enExample)
EP (1) EP2337563B1 (enExample)
JP (2) JP2012502048A (enExample)
CN (1) CN102209541B (enExample)
ES (1) ES2477552T3 (enExample)
TW (1) TWI464161B (enExample)
WO (1) WO2010028175A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2126574B1 (en) * 2007-03-08 2015-12-23 The Board of Trustees of the Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
WO2010028175A1 (en) 2008-09-08 2010-03-11 The Board Of Trustees Of The Leland Stanford Junior University Modulators of aldehyde dehydrogenase activity and methods of use thereof
EP2349279A4 (en) 2008-10-28 2013-12-25 Univ Leland Stanford Junior MODIFIERS OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF
WO2012149106A1 (en) 2011-04-29 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
EP2723717A2 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
AU2012272898A1 (en) 2011-06-24 2013-04-11 Amgen Inc. TRPM8 antagonists and their use in treatments
TWI567061B (zh) 2011-07-01 2017-01-21 吉李德科學股份有限公司 用於治療成癮之化合物
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
KR20150135332A (ko) 2013-03-14 2015-12-02 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법
US12084472B2 (en) 2015-12-18 2024-09-10 Ardelyx, Inc. Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists
TWI773657B (zh) 2015-12-18 2022-08-11 美商亞德利克斯公司 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物
FR3054564B1 (fr) * 2016-07-28 2018-08-31 Advanced Biodesign Substrat specifique d'une isoenzyme de l'aldh
CN117105868A (zh) * 2022-05-24 2023-11-24 中国人民解放军海军军医大学 酰胺类醛脱氢酶激动剂、其合成方法及用途
CN115160285B (zh) * 2022-08-25 2022-11-29 云南大学 硫代酰胺类aldh2激动剂、制备方法及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1372549A (zh) * 1999-08-18 2002-10-02 阿方蒂农科有限公司 杀真菌剂
US20020156281A1 (en) * 1998-11-05 2002-10-24 Booth Richard John Amide inhibitors of microsomal triglyceride transfer protein
CN1457339A (zh) * 2000-09-15 2003-11-19 阿诺麦德股份有限公司 趋化因子受体结合性杂环化合物
US6762176B1 (en) * 1998-07-08 2004-07-13 Societe De Consells De Recherches Et D'applications Scientifiques (S.C.R.A.S.) 2-aminopyridine derivatives, their use as medicines and pharmaceutical compositions containing them

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2319808A (en) 1939-08-31 1943-05-25 Squibb & Sons Inc Sterol derivatives and process for producing same
DE2417763A1 (de) 1974-04-11 1975-10-30 Bayer Ag Carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4992417A (en) 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogues
US4992418A (en) 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
JPH01203351A (ja) 1988-02-05 1989-08-16 Mitsui Petrochem Ind Ltd １，４−ジヒドロキシナフタレン誘導体および医薬
JPH023351A (ja) 1988-06-16 1990-01-08 Oki Electric Ind Co Ltd 印刷装置
US4861891A (en) 1988-08-31 1989-08-29 Pfizer Inc. Antidepressant N-substituted nicotinamide compounds
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
JPH03184973A (ja) 1989-12-14 1991-08-12 Rooman Kogyo:Kk 放射線障害防護剤
US5260323A (en) * 1990-06-28 1993-11-09 Hoechst Aktiengesellschaft 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use
TW197439B (enExample) 1991-04-04 1993-01-01 Ueno Pharmaceutics Applic Res Co Ltd
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
DE4201047A1 (de) 1992-01-17 1993-07-22 Bayer Ag Substituierte isoxazolcarbonsaeureamide
US5272137A (en) 1992-02-14 1993-12-21 Mcneil-Pfc, Inc. Aqueous pharmaceutical suspension for pharmaceutical actives
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
US5294637A (en) 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
JP2994182B2 (ja) 1992-07-23 1999-12-27 石原産業株式会社 アミド系化合物又はその塩、それらの製造方法及びそれらを含有する有害動物防除剤
US5202448A (en) 1992-08-14 1993-04-13 Napro Biotherapeutics, Inc. Processes of converting taxanes into baccatin III
US5415869A (en) 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
US5461031A (en) 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5504188A (en) 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
US5474978A (en) 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US5547929A (en) 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
JP3833281B2 (ja) * 1995-02-03 2006-10-11 日本曹達株式会社 ２，６−ジクロロイソニコチン酸ベンジルアミド誘導体及び植物病害防除剤
YU18596A (sh) 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
EP1019385B1 (en) 1995-09-15 2004-01-14 PHARMACIA & UPJOHN COMPANY Aminoaryl oxazolidinone n-oxides
US6072050A (en) 1996-06-11 2000-06-06 Pioneer Hi-Bred International, Inc. Synthetic promoters
FR2751645B1 (fr) 1996-07-29 1998-12-24 Sanofi Sa Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales
ZA984697B (en) 1997-06-13 1999-12-01 Lilly Co Eli Stable insulin formulations.
DE69835688T2 (de) 1997-10-31 2007-10-04 Aventis Pharma Ltd., West Malling Substituierte anilide
CA2314869A1 (en) 1997-12-22 1999-07-01 William Leonard Scott Catalyst and method for amide formation
US6384080B1 (en) 1998-04-20 2002-05-07 Fujisawa Pharmaceutical Co., Ltd. Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase
AU775388B2 (en) 1998-11-25 2004-07-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Scavenger compounds
AU1466001A (en) 1999-11-05 2001-05-14 Phase-1 Molecular Toxicology Methods of determining individual hypersensitivity to an agent
WO2001079489A2 (en) 2000-04-18 2001-10-25 Millennium Pharmaceuticals, Inc. 39228, a human alcohol dehydrogenase and uses therefor
AU2001288432A1 (en) 2000-09-01 2002-03-22 Icos Corporation Materials and methods to potentiate cancer treatment
DE60137435D1 (de) 2000-09-15 2009-03-05 Anormed Inc Chemokin rezeptor bindenden heterozyklische verbindungen
WO2002053544A1 (en) 2000-12-29 2002-07-11 Darwin Discovery Ltd. Pharmaceutical uses and synthesis of nicotinanilide-n-oxides
DOP2002000332A (es) 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
US6678516B2 (en) 2001-05-21 2004-01-13 Nokia Corporation Method, system, and apparatus for providing services in a privacy enabled mobile and Ubicom environment
US7547716B2 (en) 2001-06-08 2009-06-16 Institute Of Medicinal Molecular Design, Inc. Sulfonamide derivatives
JPWO2003030937A1 (ja) 2001-10-05 2005-01-20 小野薬品工業株式会社 ミトコンドリアルベンゾジアゼピン受容体アンタゴニストからなるストレス疾患の治療剤
DE10149674A1 (de) 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung
US20030100034A1 (en) * 2001-10-16 2003-05-29 Millennium Pharmaceuticals, Inc. 9136, a human aldehyde dehydrogenase family member and uses therefor
PY0300568A (es) 2002-01-31 2004-10-01 Pfizer Prod Inc Metabolitos del acido(3-{[4-terc-butilbencil)-(piridin-3-sulfonil)amino]metil}fenoxi)acetico
US20050101590A1 (en) 2002-02-19 2005-05-12 Kiyoshi Yasui Antipruritics
GB2403474B (en) 2002-04-18 2006-10-11 Inst Med Molecular Design Inc Amide derivatives
GB0215650D0 (en) 2002-07-05 2002-08-14 Cyclacel Ltd Bisarylsufonamide compounds
CA2497979A1 (en) 2002-09-06 2004-03-18 Elan Pharmaceuticals, Inc. 1, 3-diamino-2-hydroxypropane prodrug derivatives
EP1402888A1 (en) 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors
EP1402887A1 (en) 2002-09-18 2004-03-31 Jerini AG New compounds for the inhibition of undesired cell proliferation and use thereof
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
US7022850B2 (en) 2003-05-22 2006-04-04 Bristol-Myers Squibb Co. Bicyclicpyrimidones and their use to treat diseases
JP4359754B2 (ja) * 2003-07-03 2009-11-04 三菱瓦斯化学株式会社 基板の洗浄剤
WO2005007889A1 (en) 2003-07-21 2005-01-27 Oncotherapy Science, Inc. Method for diagnosing colorectal cancers
WO2005011561A2 (en) 2003-08-04 2005-02-10 Labcoat, Ltd. Stent coating apparatus and method
GB0318814D0 (en) * 2003-08-11 2003-09-10 Smithkline Beecham Corp Novel compounds
EP1661572A1 (en) 2003-08-18 2006-05-31 Shionogi & Co., Ltd. Novel use of cannabinoid receptor agonist
FR2861071B1 (fr) 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
FR2861074B1 (fr) 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
JP2007518401A (ja) 2003-12-09 2007-07-12 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ ミトコンドリアアルデヒドデヒドロゲナーゼ−２を調節するための方法および組成物
GT200500013A (es) * 2004-01-23 2005-08-10 Amidas herbicidas
TW200534852A (en) 2004-03-03 2005-11-01 Convivia 4-methylpyrazole formulations for inhibiting ethanol intolerance
WO2005110422A2 (en) 2004-05-19 2005-11-24 Boehringer Ingelheim International Gmbh Treatment of diseases associated with altered level of amyloid beta peptides
CN1749415A (zh) 2004-09-15 2006-03-22 上海人类基因组研究中心 硝酸甘油治疗急性心绞痛疗效检测方法和试剂盒
ES2377758T3 (es) * 2004-11-12 2012-03-30 Bristol-Myers Squibb Company Compuestos tricíclicos basados en tiazolo[4,5-b]piridina imidazo-fusionada y composiciones farmacéuticas que los comprenden
US7888374B2 (en) * 2005-01-28 2011-02-15 Abbott Laboratories Inhibitors of c-jun N-terminal kinases
DOP2006000051A (es) 2005-02-24 2006-08-31 Lilly Co Eli Inhibidores de vegf-r2 y métodos
RS20080118A (sr) 2005-09-23 2009-05-06 Pfizer Products Inc., Piridinaminosulfonil supstituisani benzamidi kao inhibitori citohroma p450 3a4 (cyp3a4)
BRPI0620151A2 (pt) 2005-12-22 2010-06-29 Wyeth Corp composto; composição farmacêutica; método de tratar ou inibir o crescimento de células tumorais cancerosas em um mamìfero que deste necessita; método; e processo
WO2007110237A2 (en) 2006-03-28 2007-10-04 Novartis Ag Amide derivatives and their application for the treatment of g protein related diseases
EP2018863B9 (en) 2006-05-16 2015-02-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
WO2007136707A2 (en) 2006-05-17 2007-11-29 University Of Utah Research Foundation Methods and compositions related to eosinophil regulation
US20080003585A1 (en) 2006-06-29 2008-01-03 Bio-Rad Laboratories, Inc., A Corporation Of The State Of Delaware Purification and amplification of nucleic acids in a microfluidic device
EP2046769A2 (en) 2006-07-27 2009-04-15 Cv Therapeutics, Inc. Aldh-2 inhibitors in the treatment of addiction
PE20080906A1 (es) 2006-08-17 2008-07-05 Kemia Inc Derivados heteroarilo como inhibidores de citocina
WO2008024497A2 (en) 2006-08-25 2008-02-28 Vitae Pharmaceuticals, Inc. INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE TYPE 1
EP1932834B1 (en) * 2006-12-11 2011-04-27 The Genetics Company, Inc. Aromatic 1,4-DI-Carboxylamides and their use
CN101611007A (zh) * 2006-12-20 2009-12-23 先灵公司 新颖的jnk抑制剂
CA2672960A1 (en) 2006-12-20 2008-07-10 Schering Corporation Novel jnk inhibitors
WO2008103354A2 (en) 2007-02-20 2008-08-28 Cropsolution, Inc. Modulators of acetyl-coenzyme a carboxylase and methods of use thereof
EP2126574B1 (en) 2007-03-08 2015-12-23 The Board of Trustees of the Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
US8642660B2 (en) 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2009137045A2 (en) 2008-05-07 2009-11-12 The Board Of Trustees Of The Leland Stanford Junior University Crystal structure of aldehyde dehydrogenase and methods of use thereof
WO2009146555A1 (en) * 2008-06-04 2009-12-10 Ambrilia Biopharma Inc. Hiv integrase inhibitors from pyridoxine
MX2010014572A (es) * 2008-06-27 2011-03-24 Novartis Ag Compuestos organicos.
WO2010028175A1 (en) 2008-09-08 2010-03-11 The Board Of Trustees Of The Leland Stanford Junior University Modulators of aldehyde dehydrogenase activity and methods of use thereof
EP2349279A4 (en) 2008-10-28 2013-12-25 Univ Leland Stanford Junior MODIFIERS OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF
MX2011012712A (es) 2009-05-29 2012-01-30 Raqualia Pharma Inc Derivados de carboxamida sustituidos con arilo como bloqueadores del canal de calcio o sodio.
AU2011317855B2 (en) 2010-10-20 2015-04-30 Grunenthal Gmbh Substituted 6-amino-nicotinamides as KCNQ2/3 modulators
US20140088187A1 (en) 2010-12-14 2014-03-27 Beth Israel Deaconess Medical Center Androgen receptor inhibitors and methods of use thereof
WO2012106534A2 (en) 2011-02-02 2012-08-09 The Regents Of The University Of California Hiv integrase inhibitors
WO2012149106A1 (en) 2011-04-29 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
CN103998442B (zh) 2011-08-29 2016-09-14 无限药品股份有限公司 杂环化合物及其用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762176B1 (en) * 1998-07-08 2004-07-13 Societe De Consells De Recherches Et D'applications Scientifiques (S.C.R.A.S.) 2-aminopyridine derivatives, their use as medicines and pharmaceutical compositions containing them
US20020156281A1 (en) * 1998-11-05 2002-10-24 Booth Richard John Amide inhibitors of microsomal triglyceride transfer protein
CN1372549A (zh) * 1999-08-18 2002-10-02 阿方蒂农科有限公司 杀真菌剂
CN1457339A (zh) * 2000-09-15 2003-11-19 阿诺麦德股份有限公司 趋化因子受体结合性杂环化合物

Also Published As

Publication number Publication date
JP2015051983A (ja) 2015-03-19
EP2337563A1 (en) 2011-06-29
US9345693B2 (en) 2016-05-24
TWI464161B (zh) 2014-12-11
WO2010028175A1 (en) 2010-03-11
JP2012502048A (ja) 2012-01-26
TW201022250A (en) 2010-06-16
EP2337563B1 (en) 2014-04-09
US20150182511A1 (en) 2015-07-02
US20130253010A1 (en) 2013-09-26
CN102209541A (zh) 2011-10-05
EP2337563A4 (en) 2012-09-12
ES2477552T3 (es) 2014-07-17
US20100063100A1 (en) 2010-03-11
US8906942B2 (en) 2014-12-09
US8354435B2 (en) 2013-01-15

Similar Documents

Publication Publication Date Title
CN102209541B (zh) 醛脱氢酶活性调节剂和其使用方法
TWI486349B (zh) 醛脫氫酶調節劑及其用法
CN101669030B (zh) 线粒体醛脱氢酶2调节剂和其使用方法
CN105358531B (zh) 线粒体醛脱氢酶‑2调节剂和其使用方法
US20140045889A1 (en) Combination Drug Containing Probucol and a Tetrazolyalkoxy-Dihydrocarbostyril Derivative With Superoxide Supressant Effects
AU2014250605A1 (en) Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Address after: American California

Applicant after: The Board of Trustees of the Leland Stanford Junior University

Address before: American California

Applicant before: The Board of Trustees of the Leland Stanford Junior Univ.

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV. TO: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160518

Termination date: 20190903