CN102203098A - 作为细胞增殖抑制剂的嘧啶并[5，4-d]嘧啶 - Google Patents

作为细胞增殖抑制剂的嘧啶并[5，4-d]嘧啶 Download PDF

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Publication number
CN102203098A
CN102203098A CN2009801439757A CN200980143975A CN102203098A CN 102203098 A CN102203098 A CN 102203098A CN 2009801439757 A CN2009801439757 A CN 2009801439757A CN 200980143975 A CN200980143975 A CN 200980143975A CN 102203098 A CN102203098 A CN 102203098A
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CN
China
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alkyl
compound
hydrogen
optionally substituted
membered
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Pending
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CN2009801439757A
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English (en)
Chinese (zh)
Inventor
安德烈亚斯.曼托里迪斯
乔格.达曼
彼得.艾特迈耶
克里斯琴.克莱因
斯蒂芬.斯图勒
艾琳.威泽尼格
斯蒂芬.K.扎恩
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40297852&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102203098(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CN102203098A publication Critical patent/CN102203098A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN2009801439757A 2008-09-08 2009-09-08 作为细胞增殖抑制剂的嘧啶并[5，4-d]嘧啶 Pending CN102203098A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08163897 2008-09-08
EP08163897.5 2008-09-08
PCT/EP2009/061656 WO2010026262A1 (en) 2008-09-08 2009-09-08 Pyrido [5, 4-d] pyrimidines as cell proliferation inhibitors

Publications (1)

Publication Number Publication Date
CN102203098A true CN102203098A (zh) 2011-09-28

Family

ID=40297852

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801439757A Pending CN102203098A (zh) 2008-09-08 2009-09-08 作为细胞增殖抑制剂的嘧啶并[5，4-d]嘧啶

Country Status (16)

Country Link
US (1) US8653087B2 (https=)
EP (1) EP2350083B1 (https=)
JP (1) JP5576379B2 (https=)
KR (1) KR20110063528A (https=)
CN (1) CN102203098A (https=)
AR (1) AR073501A1 (https=)
AU (1) AU2009289196A1 (https=)
CA (1) CA2736306A1 (https=)
CL (1) CL2011000489A1 (https=)
IL (1) IL211136A0 (https=)
MX (1) MX2011002431A (https=)
NZ (1) NZ591493A (https=)
RU (1) RU2011113402A (https=)
TW (1) TW201014860A (https=)
WO (1) WO2010026262A1 (https=)
ZA (1) ZA201101090B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117177973A (zh) * 2021-04-19 2023-12-05 蒙特利尔大学 吡啶并[3,2-d]嘧啶化合物及其用于治疗增殖性疾病的用途

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CL2008001943A1 (es) 2007-07-02 2009-09-11 Boehringer Ingelheim Int Compuestos derivados de fenil-triazol, inhibidores de enzimas de señales especificas que participan del control de la proliferacion celular; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer, infecciones, enfermedades inflamatorias y autoinmunes.
TW201014860A (en) 2008-09-08 2010-04-16 Boehringer Ingelheim Int New chemical compounds
US8778929B2 (en) 2008-09-29 2014-07-15 Boehringer Ingelheim International Gmbh Substituted heteroaryl inhibitors of B-RAF
EP2398797B1 (en) * 2009-02-17 2013-11-06 Boehringer Ingelheim International GmbH Pyrimido[5,4-d]pyrimidine derivatives for the inhibition of tyrosine kinases
NZ596538A (en) 2009-05-12 2014-04-30 Romark Lab Lc Haloalkyl heteroaryl benzamide compounds
CN108042535A (zh) 2009-06-26 2018-05-18 罗马克实验室有限公司 用于治疗流感的化合物和方法
WO2011117382A1 (en) 2010-03-26 2011-09-29 Boehringer Ingelheim International Gmbh Pyridyltriazoles
WO2011117381A1 (en) 2010-03-26 2011-09-29 Boehringer Ingelheim International Gmbh B-raf kinase inhibitors
US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
ES2882807T3 (es) 2011-09-16 2021-12-02 Novartis Ag Heterociclil carboxamidas N-sustituidas
EP2825533B1 (en) 2012-03-13 2016-10-19 Basf Se Fungicidal pyrimidine compounds
WO2015036059A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
CA2923101A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
WO2018165718A1 (en) 2017-03-17 2018-09-20 Cardio Therapeutics Pty Ltd Heterocyclic inhibitors of pcsk9
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
US20240239801A1 (en) * 2021-04-19 2024-07-18 Université de Montréal Pyrimido[5,4,d]pyrimidine compounds, compositions comprising them and uses thereof
CN120035595A (zh) * 2022-10-13 2025-05-23 蒙特利尔大学 噻唑并[5,4-d]嘧啶化合物、包含其的组合物及其用途
AU2023410324A1 (en) 2022-12-22 2025-05-15 Boehringer Ingelheim International Gmbh Crystalline forms of a her2 inhibitor
CN121568696A (zh) 2023-07-28 2026-02-24 勃林格殷格翰国际有限公司 制备her2抑制剂的方法

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CN1212696A (zh) * 1996-03-06 1999-03-31 卡尔·托马博士公司 嘧啶并[5,4－d]嘧啶,含这种化合物的药物,它们的用途和其制备方法
CA2650611A1 (en) * 2006-05-15 2007-11-29 Irm Llc Compositions and methods for fgf receptor kinases inhibitors

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WO2011117382A1 (en) 2010-03-26 2011-09-29 Boehringer Ingelheim International Gmbh Pyridyltriazoles
WO2011117381A1 (en) 2010-03-26 2011-09-29 Boehringer Ingelheim International Gmbh B-raf kinase inhibitors
US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
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CN1212696A (zh) * 1996-03-06 1999-03-31 卡尔·托马博士公司 嘧啶并[5,4－d]嘧啶,含这种化合物的药物,它们的用途和其制备方法
CA2650611A1 (en) * 2006-05-15 2007-11-29 Irm Llc Compositions and methods for fgf receptor kinases inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117177973A (zh) * 2021-04-19 2023-12-05 蒙特利尔大学 吡啶并[3,2-d]嘧啶化合物及其用于治疗增殖性疾病的用途

Also Published As

Publication number Publication date
EP2350083A1 (en) 2011-08-03
MX2011002431A (es) 2011-04-05
US20120094975A1 (en) 2012-04-19
RU2011113402A (ru) 2012-10-20
AR073501A1 (es) 2010-11-10
WO2010026262A1 (en) 2010-03-11
AU2009289196A1 (en) 2010-03-11
ZA201101090B (en) 2012-10-31
CA2736306A1 (en) 2010-03-11
IL211136A0 (en) 2011-04-28
CL2011000489A1 (es) 2011-07-15
JP5576379B2 (ja) 2014-08-20
NZ591493A (en) 2012-07-27
TW201014860A (en) 2010-04-16
JP2012502010A (ja) 2012-01-26
EP2350083B1 (en) 2017-05-17
KR20110063528A (ko) 2011-06-10
US8653087B2 (en) 2014-02-18

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Application publication date: 20110928