CN1021911C - 取代的噻吩并咪唑衍生物的制备方法 - Google Patents

取代的噻吩并咪唑衍生物的制备方法 Download PDF

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Publication number
CN1021911C
CN1021911C CN87100719A CN87100719A CN1021911C CN 1021911 C CN1021911 C CN 1021911C CN 87100719 A CN87100719 A CN 87100719A CN 87100719 A CN87100719 A CN 87100719A CN 1021911 C CN1021911 C CN 1021911C
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CN
China
Prior art keywords
ome
och
oac
imidazoles
oet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN87100719A
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English (en)
Chinese (zh)
Other versions
CN87100719A (zh
Inventor
翰斯·约晨·兰格
罗伯特·里波尔
安德里斯·W·赫尔林格
克劳斯·威德曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
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Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19863605395 external-priority patent/DE3605395A1/de
Priority claimed from DE19863623683 external-priority patent/DE3623683A1/de
Priority claimed from DE19873700436 external-priority patent/DE3700436A1/de
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to CN 90107100 priority Critical patent/CN1026063C/zh
Publication of CN87100719A publication Critical patent/CN87100719A/zh
Application granted granted Critical
Publication of CN1021911C publication Critical patent/CN1021911C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN87100719A 1986-02-20 1987-02-19 取代的噻吩并咪唑衍生物的制备方法 Expired - Fee Related CN1021911C (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 90107100 CN1026063C (zh) 1986-02-20 1987-02-19 含取代的噻吩并咪唑衍生物的药物组合物的制备方法

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE19863605395 DE3605395A1 (de) 1986-02-20 1986-02-20 Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
DEP3605395.3 1986-02-20
DE19863623683 DE3623683A1 (de) 1986-07-12 1986-07-12 Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
DEP3623683.7 1986-07-12
DEP3700436.0 1987-01-09
DE19873700436 DE3700436A1 (de) 1987-01-09 1987-01-09 Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN 90107100 Division CN1026063C (zh) 1986-02-20 1987-02-19 含取代的噻吩并咪唑衍生物的药物组合物的制备方法

Publications (2)

Publication Number Publication Date
CN87100719A CN87100719A (zh) 1987-09-09
CN1021911C true CN1021911C (zh) 1993-08-25

Family

ID=27194035

Family Applications (1)

Application Number Title Priority Date Filing Date
CN87100719A Expired - Fee Related CN1021911C (zh) 1986-02-20 1987-02-19 取代的噻吩并咪唑衍生物的制备方法

Country Status (22)

Country Link
US (1) US4845118A (enExample)
EP (1) EP0234485B1 (enExample)
JP (1) JPH0633275B2 (enExample)
KR (2) KR950001025B1 (enExample)
CN (1) CN1021911C (enExample)
AR (1) AR246739A1 (enExample)
AU (1) AU590390B2 (enExample)
CA (1) CA1337197C (enExample)
DE (1) DE3777855D1 (enExample)
DK (1) DK85087A (enExample)
EG (1) EG18128A (enExample)
ES (1) ES2032394T3 (enExample)
FI (1) FI870672A7 (enExample)
GR (1) GR3004765T3 (enExample)
HU (1) HU197330B (enExample)
IE (1) IE60572B1 (enExample)
IL (1) IL81609A (enExample)
MA (1) MA20880A1 (enExample)
NO (1) NO170155C (enExample)
NZ (1) NZ219320A (enExample)
PT (1) PT84319B (enExample)
TN (1) TNSN87024A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI861772L (fi) * 1985-05-07 1986-11-08 Chemie Linz Ag Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning.
CA1256109A (en) * 1986-09-10 1989-06-20 Franz Rovenszky Process for the preparation of derivatives of 4, 5-dihydrooxazoles
US4912101A (en) * 1987-03-13 1990-03-27 Fujirebio Kabushiki Kaisha 4-aminomethyl-pyridyl-2-oxy derivatives having anti-ulcer activity
DE3723327A1 (de) * 1987-07-15 1989-02-02 Hoechst Ag Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer, magenschutzmittel sowie als medikament gegen intestinale entzuendungen
AU622866B2 (en) * 1987-07-21 1992-04-30 Hoechst Aktiengesellschaft Substituted thienoimidazole derivatives, processes for their preparation, pharmaceutical formulations containing them and their use as gastric acid secretion inhibitors
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
TNSN88083A1 (fr) * 1987-08-15 1990-07-10 Hoechst Ag Procede de preparation de nouveaux derives de thieno-imidazole substitues
DE3851133D1 (de) * 1987-11-13 1994-09-22 Hoechst Ag Substituierte Thienoimidazol-Derivate, Verfahren zu ihrer Herstellung, sie enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Magensäuresekretionshemmer.
FI885878A7 (fi) * 1987-12-22 1989-06-23 Hoechst Ag Substituoituja tienoimidatsolijohdannaisia, menetelmä niiden valmistamiseksi, niitä sisältäviä farmaseuttisia koostumuksia sekä näiden käyttö mahahapon erityksen inhibiittoreina
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
SI1187601T1 (sl) 1999-06-07 2005-12-31 Altana Pharma Ag Novi pripravek in dajalna oblika, ki obsega kislinsko labilen inhibitor protonske crpalke
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
EP1534278A4 (en) 2002-08-01 2006-09-06 Nitromed Inc NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD
CA2529984C (en) 2003-06-26 2012-09-25 Isa Odidi Oral multi-functional pharmaceutical capsule preparations of proton pump inhibitors
ES2376466T3 (es) * 2004-05-07 2012-03-14 Nycomed Gmbh Forma de dosificación farmacéutica que comprende peletes, as�? como su procedimiento de fabricación.
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
CN104825397A (zh) 2006-04-03 2015-08-12 伊萨·奥迪迪 含有机溶胶涂层的受控释放递送物件
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
EP2086543A2 (en) 2006-10-27 2009-08-12 The Curators of the University of Missouri Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same
US20080194307A1 (en) * 2007-02-13 2008-08-14 Jeff Sanger Sports-based game of chance
WO2009105568A1 (en) 2008-02-20 2009-08-27 The Curators Of The University Of Missouri Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3132167A1 (de) 1981-08-14 1983-03-03 Hoechst Ag, 6000 Frankfurt "5(6)-phenylsulfonyloxy-benzimidazolderivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung gegen leberegel"
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4472409A (en) 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
GB8417171D0 (en) * 1984-07-05 1984-08-08 Beecham Group Plc Compounds
AU568441B2 (en) 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
FI861772L (fi) * 1985-05-07 1986-11-08 Chemie Linz Ag Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning.
WO1987005296A1 (en) * 1986-03-07 1987-09-11 Pfizer Inc. 2-[(2-pyridyl)methylsulfinyl]thienoimidazoles and related compounds as antiulcer agents

Also Published As

Publication number Publication date
PT84319A (de) 1987-03-01
PT84319B (pt) 1989-09-14
AR246739A1 (es) 1994-09-30
MA20880A1 (fr) 1987-10-01
EP0234485A1 (de) 1987-09-02
CA1337197C (en) 1995-10-03
IE60572B1 (en) 1994-07-27
KR950001025B1 (ko) 1995-02-07
FI870672A0 (fi) 1987-02-18
EP0234485B1 (de) 1992-04-01
IL81609A (en) 1994-10-21
HUT44255A (en) 1988-02-29
NO170155C (no) 1992-09-16
FI870672A7 (fi) 1987-08-21
TNSN87024A1 (fr) 1990-01-01
IL81609A0 (en) 1987-09-16
AU6906687A (en) 1987-08-27
JPH0633275B2 (ja) 1994-05-02
DK85087A (da) 1987-08-21
HU197330B (en) 1989-03-28
IE870421L (en) 1987-08-20
DE3777855D1 (de) 1992-05-07
NO870666L (no) 1987-08-21
CN87100719A (zh) 1987-09-09
NO170155B (no) 1992-06-09
ES2032394T3 (es) 1993-02-16
KR870007934A (ko) 1987-09-23
EG18128A (en) 1992-08-30
NO870666D0 (no) 1987-02-19
GR3004765T3 (enExample) 1993-04-28
KR890009937A (ko) 1989-08-05
NZ219320A (en) 1990-06-26
US4845118A (en) 1989-07-04
DK85087D0 (da) 1987-02-19
JPS62198683A (ja) 1987-09-02
AU590390B2 (en) 1989-11-02

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C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee