CN102178774A - Traditional Chinese medicine composition for treating drug-induced renal damage of chicken - Google Patents
Traditional Chinese medicine composition for treating drug-induced renal damage of chicken Download PDFInfo
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- CN102178774A CN102178774A CN 201110104434 CN201110104434A CN102178774A CN 102178774 A CN102178774 A CN 102178774A CN 201110104434 CN201110104434 CN 201110104434 CN 201110104434 A CN201110104434 A CN 201110104434A CN 102178774 A CN102178774 A CN 102178774A
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Abstract
The invention provides a traditional Chinese medicine composition for treating drug-induced renal damage of chicken, comprising the following components in parts by weight: 15-20 parts of fringed pink, 15-20 parts of rhizoma alismatis, 10-15 parts of plantain, 10-15 parts of lysimachia, 5-10 parts of cape jasmine, 5-10 parts of tuckahoe, 5-10 parts of white atractylodes rhizome, 1-5 parts of liquorice and 1-5 parts of phellodendron bark. The traditional Chinese medicine composition has the efficacies of clearing heat and purging fire, inducing diuresis for treating stranguria, promoting the subsidence of swelling, alleviating pain, and replenishing qi to invigorate the spleen, and can be used for treating drug-induced renal damage of chicken with exact curative effect, and the cure rate reaches above 80%.
Description
1, technical field
The invention belongs to Chinese medicine composition, particularly a kind of Chinese medicine composition for the treatment of chicken medicine renal damage.
2, background technology
In recent years, fast development along with poultry husbandry, the intensification degree is more and more higher, various antibacterials of chicken and virosis sickness rate are high, therefore a large amount of chemical medicine of application prevent and treat in the culture-cycle, cause the problem of chicken medicine renal damage more and more serious thus, this has become the major reason that the poultry husbandry benefit glides.It is depressed that the sick chicken of medicine renal damage shows as spirit, and feather is fluffy and disorderly, bows and seemingly sleeps, drinking-water increases, row's white or water sample loose stool, egg drop reduction, cut open inspection visible renal swelling, pale, hemorrhage, urate deposition, gently then make chick growth be obstructed, become the chicken fertility performance to reduce, heavy then cause mortality.This sick sickness rate is high, and the clinical diagnosis difficulty is big, is difficult to judge accurate pathogenic factor, and obstinate or end-of-dose failure, and clinical veterinary is at a loss as to what to do.The slowly long even stagnation of chicken all living creatures, expenses for medicine raises, and the price of deed reduces, and causes serious economic loss, and numerous raisers suffer untold misery, and suffer heavy losses.Therefore, strengthen understanding, analyse in depth and find out solution, to effective control primary disease, at utmost retrieve economic losses and have very important meaning this cause of disease.The prescription medicine of the disclosed treatment of prior art chicken medicine renal damage mainly comprises Western medicine and Chinese medicine two big classes, as SHENZHONG JIEDULING, renal swelling Western medicine such as disappear, Chinese medicines such as subduing swelling and detoxicating is diffusing, kidney oxazepan.This type of Western medicine is cured the symptoms, not the disease, and has safety problems such as drug residue and drug resistance; And existing Chinese medicine preparation may be unreasonable on prescription, and perhaps dosage form is unreasonable, influences drug absorption, unsatisfactory curative effect.
3, summary of the invention
The object of the present invention is to provide a kind of determined curative effect, cure rate height, toxic and side effects is little, and drug residue free does not produce chemical sproof Chinese medicine composition for the treatment of chicken medicine renal damage after the medication.
The Chinese medicine composition of treatment of the present invention chicken medicine injury of kidney comprises the component of following weight portion: Herba Dianthi 15-20, Rhizoma Alismatis 15-20, Herba Plantaginis 10-15, Herba Lysimachiae 10-15, Fructus Gardeniae 5-10, Poria 5-10, Rhizoma Atractylodis Macrocephalae 5-10, Radix Glycyrrhizae 1-5, Cortex Phellodendri 1-5.
The using method and the consumption of compositions of the present invention are: after the said composition process of preparing Chinese medicine, oven dry, pulverizing mixing are made powder, press 0.1～5.0% of complete feed weight and mix the back use.
The using method and the consumption of compositions of the present invention are: after said composition is made liquid form, convert water 1～10kg by 1ml～5ml medicinal liquid (the 1ml medicinal liquid is equivalent to the 1g raw medicinal herbs) and freely drink for the chicken group.
Compositions of the present invention has clearing away heat-fire, inducing diuresis for treating stranguria syndrome, and reducing swelling and alleviating pain, replenishing QI to invigorate the spleen can be used for treating chicken medicine renal damage.
Prescription is understood: medicament composing prescription of the present invention is according to Chinese veterinarian's theory, designs in conjunction with the state of an illness feature of chicken medicine renal damage.Main symptom is that disease spirit is depressed during chicken medicine renal damage, and happiness is slept, row's white or water sample loose stool; Kidney enlargement, pale, hemorrhage, white urate deposition.Determine clearing away heat-damp and promoting diuresis in view of the above, inducing diuresis for treating stranguria syndrome is the rule of treatment.With Herba Dianthi, Rhizoma Alismatis clearing away heat-fire, the famous medicine of inducing diuresis for treating stranguria syndrome is a monarch drug in the event side.Wherein heart-fire falls in Herba Dianthi hardship, cold, and sharp small intestinal removes damp and hotly, and the double blood system of walking is invigorated blood circulation with treating stranguria.Attacking of kidney fire let out in Rhizoma Alismatis heat clearing away cold in nature and have the diarrhea of oozing Jiao damp and hot; Promoting diuresis to eliminate damp pathogen, last can making lung-QI pure and descending, with waterway, following can the tonneau part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels and current urine.Semen Plantaginis, Herba Lysimachiae, the Fructus Gardeniae clearing away heat-damp and promoting diuresis is treating stranguria, is ministerial drug altogether, strengthens the efficacy of a drug of monarch drug.Semen Plantaginis goes into kidney, liver, lung meridian, and relieving stranguria by diuresis is not felt frustrated, and the then pure and impure branch of water channel profit is with the effect that protects the liver lung heat clearing; The sweet light profit of Herba Lysimachiae is oozed, and the liver and gall kidney channel is gone in the heat clearing away that is slightly cold, can inducing diuresis for treating stranguria syndrome, and the jaundice eliminating that also can dehumidify, removing toxic substances and promoting subsidence of swelling.It is damp and hot that Fructus Gardeniae is rushed down three warmers clearly, walks edema caused by disorder of QI to remove pathogenic heat, goes into blood system with cooling blood for hemostasis, has clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, the effect of reducing swelling and alleviating pain.Poria, the Rhizoma Atractylodis Macrocephalae are adjuvant drug.The sweet light profit of oozing of Poria wherein, property is flat not inclined to one side, and double tonify deficiency, goes into spleen, kidney, heart channel.Can eliminating dampness and diuresis, again can the spleen invigorating mind calming.The Rhizoma Atractylodis Macrocephalae is sweet, bitter, and temperature is gone into spleen, stomach warp, and the master sets upright with temperature compensation, air making-up and spleen enlivening, and the double water of dispeling is wet.Both assist monarch drug, ministerial drug to dispel the wet effect of water simultaneously as adjuvant, have the effect of tonification, are used for the syndrome of spleen-deficiency that injury of kidney causes.Radix Glycyrrhizae, Cortex Phellodendri are messenger drug.The sweet slow pain relieving of Radix Glycyrrhizae, anti-all medicine bitter colds injure one's stomach, and can the coordinating the actions of various ingredients in a prescription property of medicine.The Cortex Phellodendri master goes into kidney channel, and effect is the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels relatively, but priming power makes drug main will act on kidney and urethra to kidney.
4, the specific embodiment
Below in conjunction with specific embodiment the present invention is further described.
Embodiment 1: the Chinese medicine composition of treatment chicken medicine renal damage, the prescription composition is expressed as by weight: Herba Dianthi 15, Rhizoma Alismatis 15, Herba Plantaginis 10, Herba Lysimachiae 10, Fructus Gardeniae 5, Poria 5, the Rhizoma Atractylodis Macrocephalae 5, Radix Glycyrrhizae 1, Cortex Phellodendri 1.Raw material is selected, through concoct, oven dry, pulverize after mixing or after extracting (the 1ml medicinal liquid is equivalent to the 1g raw medicinal herbs) can make the medicine of present embodiment.
Embodiment 2: the Chinese medicine composition of treatment chicken medicine renal damage, the prescription composition is expressed as by weight: Herba Dianthi 20, Rhizoma Alismatis 20, Herba Plantaginis 15, Herba Lysimachiae 15, Fructus Gardeniae 10, Poria 10, the Rhizoma Atractylodis Macrocephalae 10, Radix Glycyrrhizae 5, Cortex Phellodendri 5.Raw material is selected, through concoct, oven dry, pulverize after mixing or after extracting (the 1m1 medicinal liquid is equivalent to the 1g raw medicinal herbs) can make the medicine of present embodiment.
Embodiment 3: the Chinese medicine composition of treatment chicken medicine renal damage, the prescription composition is expressed as by weight: Herba Dianthi 16, Rhizoma Alismatis 17, Herba Plantaginis 12, Herba Lysimachiae 13, Fructus Gardeniae 7, Poria 7, the Rhizoma Atractylodis Macrocephalae 7, Radix Glycyrrhizae 2, Cortex Phellodendri 2.Raw material is selected, through concoct, oven dry, pulverize after mixing or after extracting (the 1ml medicinal liquid is equivalent to the 1g raw medicinal herbs) can make the medicine of present embodiment.
Embodiment 4: the Chinese medicine composition of treatment chicken medicine renal damage, the prescription composition is expressed as by weight: Herba Dianthi 18, Rhizoma Alismatis 18, Herba Plantaginis 14, Herba Lysimachiae 14, Fructus Gardeniae 8, Poria 8, the Rhizoma Atractylodis Macrocephalae 8, Radix Glycyrrhizae 4, Cortex Phellodendri 4.Raw material is selected, through concoct, oven dry, pulverize after mixing or after extracting (the 1ml medicinal liquid is equivalent to the 1g raw medicinal herbs) can make the medicine of present embodiment.
Embodiment 5: treatment chicken medicine injury of kidney Chinese medicine composition, the prescription composition is expressed as by weight: Herba Dianthi 17, Rhizoma Alismatis 16, Herba Plantaginis 13, Herba Lysimachiae 12, Fructus Gardeniae 6, Poria 9, the Rhizoma Atractylodis Macrocephalae 6, Radix Glycyrrhizae 3, Cortex Phellodendri 3.Raw material is selected, through concoct, oven dry, pulverize after mixing or after extracting (the 1ml medicinal liquid is equivalent to the 1g raw medicinal herbs) can make the medicine of present embodiment.
Traditional Chinese medicine composition for treating chicken medicine renal damage test report
1 materials and methods
1.1 medicine
Test sample: provide (1ml is equivalent to the 1g crude drug) by embodiment 1-5, be followed successively by test sample 1-5.Subduing swelling and detoxicating looses (the 3rd of veterinary drug provincial standard rising national standard), Tianjin Tianheli Pharmaceutical R ﹠ D Co., Ltd., lot number: 0904017.Fu side's Sulfamethoxazole (bactrim), the smart rich Bioisystech Co., Ltd in Guangzhou produces lot number: 0801022.
1.2 experimental animal
Blue brown laying hen 2000 plumages in 70 ages in days sea are available from source, waterside, Baoding fowl industry Co., Ltd.Wherein 1800 are used for bactrim modeling test; All the other 200 as blank, and do not feed bactrim and other any medicines only give conventional feeding and management.
1.3 key instrument
Electronic balance, refrigerator, electronics biochemical instruments, optical microscope etc.
1.4 modeling test
Get bactrim using dosage and method that 1800 chickens are determined according to the modeling dosetest, carry out the modeling test.Bactrim is pressed the 2.0g/kg feed mixing and is added, and when using to the 7th day continuously, full group chicken shows as: spirit is depressed, feed intake descends.1800 chickens of full group amount to dead 50 by the 7th day 24:00, and chicken dead and that spirit is extremely depressed is dissected and finds: kidney enlargement, pale, part is piebaldism kidney sample, the kidney sections observation is found: the renal cells necrosis, and tube wall thickens, and downright bad cell blocks the renal tubules chamber.
Reject spirit extremely depressed part chicken and dead chicken, divide 7 groups, be used for follow-up test 1400 chickens.
1.5 test grouping and processing
1400 chickens of bactrim modeling success are divided into 7 processed group (comprising II, III, IV, V, VI, VII, VIII group) at random, establish 4 repetitions for every group, each repeats 50 chickens.The II group is the medicine matched group, and spice adds the diffusing 3g/kg feedstuff of subduing swelling and detoxicating in the daily ration; III, IV, V, VI, VII are followed successively by test sample 1,2, and 3,4,5 adopt the drinking-water administration, and whole day is concentrated at twice and drunk; VIII organizes negative matched group, does not add medicine.The modeling success is (promptly testing the 13rd) beginning administration after 5 days, continuous use 5 days.In addition, the I group is the blank group, 200 chickens, do not feed bactrim and other any medicines.The test grouping is as table 1.49 days experimental periods.
Table 1 test packet transaction table
1.6 feeding and management
The test chicken all adopts bilayer to raise in cages, free choice feeding and drinking-water, and 49 days experimental periods,, hen house keeps hygienically clean, the well-ventilated.
According to the large-scale feeding standard preparation of China blue brown laying hen in sea, daily ration is once got all the ready, and the sampling bottling is to be measured.Basal diet is formed and trophic level, sees Table 2.
Table 2 basal diet is formed and trophic level
Annotate: compound additive contains multivitamin, trace element and methionine, lysine etc., and the daily ration design meets NRC (1994) standard.
1.7 detect index and method
1.7.1 the mensuration of renal function index blood uric acid
Got venous blood collection under 30 chicken wing on the 12nd, 21,35,49 day from every group respectively at test, the separation of serum sample uses the electronics biochemical instruments to measure blood uric acid content.
1.7.2 kidney organ's index
Above-mentioned chicken is taken out kidney, observe and after the naked eyes of record nephridial tissue change, reject fat, weigh and calculate the kidney index.The exponential computational methods of kidney are as follows:
Kidney index=kidney net weight (g)/body weight (kg)
1.8 curative effect overall merit
Come overall merit Chinese medicine composition curative effect with mortality rate and cure rate.
Mortality rate=(dead chicken number/test chicken number of elements) * 100%; Cure rate=(curing chicken number/test chicken number of elements) * 100%
Cure: test chicken spirit is normal, and watery stool, Calx just disappear, and it is normal that appetite is recovered; Analyse kidney swelling complete obiteration, color is cerise; Lab testing uric acid content and kidney index return to normally (with blank group mean urinary acid content and kidney index is standard, is not higher than this standard and is normally).
2 results
2.1 Chinese medicine composition is to the influence of the average blood uric acid of the blue brown laying hen in sea
Chinese medicine composition the results are shown in Table 3 to the influence of the average blood uric acid of laying hen.After laying hen goes into house, carry out the wing venous blood collection on an empty stomach before beginning drinking-water and feeding, measure the content of blood uric acid, the laying hen numerical value that begins is close between each group of result, and difference is not remarkable, has comparability.When testing 21 and 35, the blood uric acid content difference of test sample group and medicine matched group test chicken is not obvious, but compare with the blank group and to have significant difference (P≤0.05), after comparing (P≤0.05) test chicken that also has significant difference with negative control group and giving test sample and control drug treatment, kidney damage takes a turn for the better to some extent.
When testing 49, the test sample group is compared with the medicine matched group, and its serum uric acid level is lower than the medicine matched group, compares no significant difference (P≤0.05) with the blank group.This presentation of results, test sample give the sick chicken therapeutic effect of injury of kidney and are better than control drug.
The average blood uric acid content of laying hen is respectively organized in table 3 test
Annotate: the expression difference that same perpendicular row contains identical shoulder motes letter in the table is significantly (P＞0.05) not, different letter representation significant differences (P≤0.05).
2.2 Chinese medicine composition is to the influence of the blue brown laying hen kidney in sea
Chinese medicine composition the results are shown in Table 4 to the influence of the blue brown laying hen kidney in sea.After laying hen goes into house, weigh on an empty stomach before beginning drinking-water and feeding, the laying hen body weight is close between each group, and difference is not remarkable.Tested the 12nd day, kidney index and the blank group of II, III, IV, V, VI, VII, VIII group laying hen relatively have significant difference (P≤0.05), and watery stool occurs, the depressed state of appearance that waits of spirit, the piebaldism kidney also appears in the kidney surface, and the edema situation illustrates the modeling success.
When testing 21 and 35, the kidney index differential of III, IV, V, VI, VII test sample group and medicine matched group is not obvious, has significant difference but compare with the blank group, compares significant difference (P≤0.05) with negative control group; The chicken group's of test sample group and medicine matched group watery stool and mental condition take a favorable turn, and the piebaldism kidney of kidney outward appearance and edema situation are also being alleviated.
When testing 49, the test sample group is compared with the medicine matched group, and its kidney index is a little less than the medicine matched group; 5 groups of test sample test chicken group kidney swelling complete obiterations, color is cerise, and shows very nearly the samely with the chicken group of blank group, but the control drug group has minority chicken group still to show morbid state.This result of the test explanation, test sample are used for the treatment of the back effect of chicken medicine injury of kidney and are better than the control drug group, can make the disease chicken kidney return to normal level.
Table 4 Chinese medicine composition is to the exponential influence of the blue brown laying hen kidney in sea
Annotate: the expression difference that same perpendicular row contains identical shoulder motes letter in the table is significantly (P＞0.05) not, different letter representation significant differences (P≤0.05).
2.3 curative effect Comprehensive Assessment result
This test is made the medicine renal injury model with bactrim, utilize Chinese medicine composition of the present invention to treat, and contrast treatment, test after 49 days with diffusing work of subduing swelling and detoxicating, the tracking and measuring uric acid content, and the aggregation of data that the morphology outward appearance of the blue brown chicken kidney in kidney exponential sum sea is observed is evaluated.Evaluation result sees Table 5.
The aggregation of data evaluation result of the brown laying hen of table 5 the 49th Ri Hailan (50 of sums)
| Group | Cure number (only) | Death toll (only) | Cure rate (%) | Mortality rate (%) |
| The blank group | 0 | 0 | ||
| The medicine matched group | 35 | 5 | 70.00 | 10.00 |
| Test sample 1 | 41 | 3 | 82.00 | 6.00 |
| Test sample 2 | 39 | 5 | 78.00 | 10.00 |
| Test sample 3 | 42 | 4 | 84.00 | 8.00 |
| Test sample 4 | 41 | 4 | 82.00 | 8.00 |
| Test sample 5 | 44 | 3 | 88.00 | 6.00 |
| Negative control group | 40 | 80.00 |
Above result shows that embodiment of the invention 1-5 medicine is 82.80% to the sea average cure rate of blue brown laying hen medicine injury of kidney, is higher than 12.8 percentage points of the diffusing groups of subduing swelling and detoxicating.
3 conclusions
Chinese medicine composition provided by the invention can be used for the damage of curative rerum natura Testis et penis Gallus domesticus, its determined curative effect, and the cure rate height has clinical value.
Claims (1)
1. Chinese medicine composition for the treatment of chicken medicine renal damage, it is characterized in that the raw material of described Chinese medicine composition comprises the component of following weight portion: Herba Dianthi 15-20, Rhizoma Alismatis 15-20, Herba Plantaginis 10-15, Herba Lysimachiae 10-15, Fructus Gardeniae 5-10, Poria 5-10, Rhizoma Atractylodis Macrocephalae 5-10, Radix Glycyrrhizae 1-5, Cortex Phellodendri 1-5.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103463470A (en) * | 2013-08-10 | 2013-12-25 | 安徽快康生物科技有限公司 | Traditional Chinese medicinal composition for protecting liver and kidney of chicken |
| CN106310031A (en) * | 2015-06-24 | 2017-01-11 | 陆雪 | Drug for treating chicken gout |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899531A (en) * | 2006-07-05 | 2007-01-24 | 河北农业大学 | Medicine for treating chicken kidney enlargement disease |
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2011
- 2011-04-26 CN CN2011101044342A patent/CN102178774B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899531A (en) * | 2006-07-05 | 2007-01-24 | 河北农业大学 | Medicine for treating chicken kidney enlargement disease |
Non-Patent Citations (4)
| Title |
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| 《北方牧业》 20110105 马爱团 鸡肾病的中兽医辨证与治疗 25 1 , * |
| 《北方牧业》 20110105 马爱团 鸡肾病的中兽医辨证与治疗 25 1 , 2 * |
| 《山东家禽》 20030530 舒刚 鸡尿酸盐代谢障碍的发生及其中西医防治 28-31 1 , 第5期 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103463470A (en) * | 2013-08-10 | 2013-12-25 | 安徽快康生物科技有限公司 | Traditional Chinese medicinal composition for protecting liver and kidney of chicken |
| CN103463470B (en) * | 2013-08-10 | 2016-03-02 | 安徽快康生物科技有限公司 | A kind of chicken Chinese medicine composition protecting the liver logical kidney |
| CN106310031A (en) * | 2015-06-24 | 2017-01-11 | 陆雪 | Drug for treating chicken gout |
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