CN104547501A - Children traditional Chinese medicine formula for treating acute nasosinusitis - Google Patents

Abstract

The invention discloses a children traditional Chinese medicine formula for treating acute nasosinusitis, which comprises the following traditional Chinese medicine raw materials: 42g liquorice, 26g mint, 19g magnolia flower, 32g radix scutellariae, 23g fructus forsythiae, 18g lily, 31g radices trichosanthis, 21g salvia miltiorrhiza, 29g honeysuckle, 33g radix angelicae, 17g radix paeoniae alba, 42g plantain herb, 29g rhizoma typhonii, 34g spina gleditsiae, 53g honeysuckle stem, 180g peanut, 60g egg white and 45g white granulated sugar. Various traditional Chinese medicines having targeted ingredients for treating the acute nasosinusitis are adopted to exert a mutual synergistic effect; at the same time, the peanut is added as an auxiliary material; the traditional Chinese medicine formula has effects of detoxifying, evacuating pus, tonifying a lung and qi, treating the acute nasosinusitis, dredging collaterals and alleviating pain, is a specific traditional Chinese medicine for treating the acute nasosinusitis, has a significant and reliable curative effect, mild medicine property, no toxic or side effects, an effective rate up to 95% and a cure rate of 85%.

Description

A kind of child's Chinese medicine formula for the treatment of acute sinusitis

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to a kind of child's Chinese medicine formula for the treatment of acute sinusitis.

Background technology

Nasosinustis and acute sinusitis, comprise nasosinustis and chronic nasosinustis.For nose section common disease, chronic person is in the majority.Front group of nasal sinuses is high compared with the sickness rate of posterior nasal sinuses, and wherein maxillary sinus is the most common.Nasosinustis can betide side, also can bilateral.A hole morbidity can be limited to, also can involve many holes.Normal companioned with headache, nasal obstruction, hyposmia, nasal sinuses district pain, then empty endlessly dizzy for a long time.Many because of the evil poison of affection due to external wind and heat, or wind and cold invasion and attack, heat-transformation for a long time, pathogenic heat are followed through upper steaming, criminal and nose key; Or gallbladder meridian is hot, with through upper criminal, steam the nose key that burns; Or damp-heat in the spleen and stomach, follow stomach through on to disturb etc. and cause.The Chinese medicine preparation for the treatment of acute sinusitis is in the market of a great variety, but great majority also exist take effect slow, the course for the treatment of long, the easy shortcoming such as recurrence, bring larger misery and inconvenience to patient and there is no the Chinese medicine formula for child, needing improvement badly.

Summary of the invention

Object of the present invention provides a kind of child's Chinese medicine formula for the treatment of acute sinusitis, solves one or more in above-mentioned prior art problem.

According to an aspect of the present invention, there is provided a kind of child's Chinese medicine formula for the treatment of acute sinusitis, the raw material of Chinese medicine composition by following formula and weight: Radix Glycyrrhizae 36-49 gram, Herba Menthae 15-29 gram, Flos Magnoliae 10-25 gram, Radix Scutellariae 20-45 gram, Fructus Forsythiae 15-29 gram, Bulbus Lilii 10-25 gram, Radix Trichosanthis 20-45 gram, Radix Salviae Miltiorrhizae 15-27 gram, Flos Lonicerae 20-39 gram, Radix Angelicae Dahuricae 20-45 gram, Radix Paeoniae Alba 10-25 gram, Herba Plantaginis 36-49 gram, Rhizoma Typhonii 20-36 gram, Spina Gleditsiae 20-45 gram, Caulis Lonicerae 39-70 gram, Semen arachidis hypogaeae 129-195 gram, Ovum Gallus domesticus album 39-80 gram and white sugar 29-60 gram.

In some embodiments, by the raw material of Chinese medicine composition of following formula and weight: Radix Glycyrrhizae 37-47 gram, Herba Menthae 20-28 gram, Flos Magnoliae 13-23 gram, Radix Scutellariae 25-39 gram, Fructus Forsythiae 18-28 gram, Bulbus Lilii 12-22 gram, Radix Trichosanthis 25-36 gram, Radix Salviae Miltiorrhizae 17-25 gram, Flos Lonicerae 25-36 gram, Radix Angelicae Dahuricae 25-39 gram, Radix Paeoniae Alba 15-20 gram, Herba Plantaginis 39-43 gram, Rhizoma Typhonii 23-33 gram, Spina Gleditsiae 29-39 gram, Caulis Lonicerae 45-65 gram, Semen arachidis hypogaeae 170-190 gram, Ovum Gallus domesticus album 49-70 gram and white sugar 36-55 gram.

In some embodiments, by the raw material of Chinese medicine composition of following formula and weight: Radix Glycyrrhizae 39-44 gram, Herba Menthae 25-27 gram, Flos Magnoliae 18-20 gram, Radix Scutellariae 29-34 gram, Fructus Forsythiae 22-24 gram, Bulbus Lilii 16-20 gram, Radix Trichosanthis 29-32 gram, Radix Salviae Miltiorrhizae 20-22 gram, Flos Lonicerae 28-29 gram, Radix Angelicae Dahuricae 32-34 gram, Radix Paeoniae Alba 16-18 gram, Herba Plantaginis 41-43 gram, Rhizoma Typhonii 28-29 gram, Spina Gleditsiae 33-36 gram, Caulis Lonicerae 49-56 gram, Semen arachidis hypogaeae 175-185 gram, Ovum Gallus domesticus album 55-65 gram and white sugar 39-49 gram.

In some embodiments, form by the raw material of Chinese medicine of following formula and weight: 42 grams, Radix Glycyrrhizae, Herba Menthae 26 grams, Flos Magnoliae 19 grams, Radix Scutellariae 32 grams, Fructus Forsythiae 23 grams, Bulbus Lilii 18 grams, Radix Trichosanthis 31 grams, Radix Salviae Miltiorrhizae 21 grams, Flos Lonicerae 29 grams, the Radix Angelicae Dahuricae 33 grams, the Radix Paeoniae Alba 17 grams, Herba Plantaginis 42 grams, Rhizoma Typhonii 29 grams, Spina Gleditsiae 34 grams, Caulis Lonicerae 53 grams, Semen arachidis hypogaeae 180 grams, 60 grams, Ovum Gallus domesticus album and white sugar 45 grams.

According to another aspect of the present invention, a kind of preparation method for the treatment of child's Chinese medicine formula of acute sinusitis is provided, it is characterized in that comprising the following steps:

Step one: get Herba Menthae, Flos Magnoliae, Radix Scutellariae, Fructus Forsythiae, Bulbus Lilii and Radix Trichosanthis mix homogeneously, add 3-5 times of water gaging, reflux 4-5h, distillation, after collecting first time distillate, again distill 2-3h, after collecting second time distillate, merge distillate and second time distillate for the first time, extract volatile oil, for subsequent use;

Step 2: get Radix Salviae Miltiorrhizae, Flos Lonicerae, the Radix Angelicae Dahuricae, the Radix Paeoniae Alba, Herba Plantaginis and Rhizoma Typhonii mix homogeneously, adds 3-6 times of micro-the boiling of water gaging and decocts 1-2h, filter, and filtering residue adds 3-6 times of micro-the boiling of water gaging again and decocts 39-60min, filters, merging filtrate, extracts filtrate, for subsequent use;

Step 3: get Spina Gleditsiae, Caulis Lonicerae and Radix Glycyrrhizae mix homogeneously, be ground into coarse powder, by percolation preparation, uses 49-70% ethanol as solvent, and after dipping 23-37h, slowly percolation, treats that effective ingredient is filtered out completely, collects liquid of filtering, and reclaims ethanol, extracts liquid of filtering, for subsequent use;

Step 4: the liquid of filtering that extracts in the filtrate of extracting in combining step two and step 3, leave standstill 8-10h, filter, laying temperature, to 5-10 DEG C, adds the volatile oil extracted in step one, adds the water of 2-4 times amount, stir evenly, obtain the first mixture;

Step 5: get Ovum Gallus domesticus album and white sugar part is put in bowl, stirs, is stirred to till becoming slurry always, makes syrup, described first mixture obtained is put into described syrup that step 5 makes and stir and become the second mixture in step 4;

Step 6: get Semen arachidis hypogaeae and pour in described second mixture obtained in step 6, be stirred to described second mixture and be wrapped on described Semen arachidis hypogaeae crust, continues to stir, until temperature cools off, obtains finished product.

A kind of child's Chinese medicine formula for the treatment of acute sinusitis provided by the invention, select the multiple Chinese medicine to the targeted composition for the treatment of acute sinusitis to play mutual synergism, add Semen arachidis hypogaeae is adjuvant simultaneously, is more conducive to children taking.Gallbladder-heat can be rushed down clearly, removing toxic substances and promoting pus discharge, invigorating the lung and benefiting vital QI, treatment acute sinusitis, dispelling cold by warming the meridian, strong muscle are invigorated blood circulation, removing obstruction in the collateral to relieve pain effect, it is treatment acute sinusitis special effect Chinese, for many years in clinical practice, cure the hundreds of example of patient, reliably evident in efficacy, mild in medicine property and, there is not toxic and side effects, effective percentage reaches 95%, cure rate 85%.

Detailed description of the invention

Treat child's Chinese medicine formula of acute sinusitis, form by the raw material of Chinese medicine of following formula and weight: 36 grams, Radix Glycyrrhizae, Herba Menthae 15 grams, Flos Magnoliae 10 grams, Radix Scutellariae 20 grams, Fructus Forsythiae 15 grams, Bulbus Lilii 10 grams, Radix Trichosanthis 20 grams, Radix Salviae Miltiorrhizae 15 grams, Flos Lonicerae 20 grams, the Radix Angelicae Dahuricae 20 grams, the Radix Paeoniae Alba 10 grams, Herba Plantaginis 36 grams, Rhizoma Typhonii 20 grams, Spina Gleditsiae 20 grams, Caulis Lonicerae 39 grams, Semen arachidis hypogaeae 129 grams, 39 grams, Ovum Gallus domesticus album and white sugar 29 grams.

Embodiment 2:

Treat child's Chinese medicine formula of acute sinusitis, form by the raw material of Chinese medicine of following formula and weight: 39 grams, Radix Glycyrrhizae, Herba Menthae 23 grams, Flos Magnoliae 15 grams, Radix Scutellariae 29 grams, Fructus Forsythiae 25 grams, Bulbus Lilii 16 grams, Radix Trichosanthis 29 grams, Radix Salviae Miltiorrhizae 23 grams, Flos Lonicerae 29 grams, the Radix Angelicae Dahuricae 29 grams, the Radix Paeoniae Alba 16 grams, Herba Plantaginis 45 grams, Rhizoma Typhonii 28 grams, Spina Gleditsiae 36 grams, Caulis Lonicerae 55 grams, Semen arachidis hypogaeae 170 grams, 65 grams, Ovum Gallus domesticus album and white sugar 49 grams.

Embodiment 3:

Treat child's Chinese medicine formula of acute sinusitis, the raw material of Chinese medicine composition by following formula and weight: 49 grams, Radix Glycyrrhizae, Herba Menthae 29 grams, Flos Magnoliae 25 grams, Radix Scutellariae 45 grams, Fructus Forsythiae 29 grams, Bulbus Lilii 25 grams, Radix Trichosanthis 45 grams, Radix Salviae Miltiorrhizae 27 grams, Flos Lonicerae 39 grams, the Radix Angelicae Dahuricae 45 grams, the Radix Paeoniae Alba 25 grams, Herba Plantaginis 36-49 gram, Rhizoma Typhonii 36 grams, Spina Gleditsiae 45 grams, Caulis Lonicerae 70 grams, Semen arachidis hypogaeae 195 grams, 80 grams, Ovum Gallus domesticus album and white sugar 60 grams

Embodiment 4:

Treat child's Chinese medicine formula of acute sinusitis, the raw material of Chinese medicine composition by following formula and weight: 37 grams, Radix Glycyrrhizae, Herba Menthae 20 grams, Flos Magnoliae 13 grams, Radix Scutellariae 25 grams, Fructus Forsythiae 18 grams, Bulbus Lilii 12 grams, Radix Trichosanthis 25 grams, Radix Salviae Miltiorrhizae 17 grams, Flos Lonicerae 25 grams, the Radix Angelicae Dahuricae 25 grams, the Radix Paeoniae Alba 15 grams, Herba Plantaginis 39 grams, Rhizoma Typhonii 23 grams, Spina Gleditsiae 29 grams, Caulis Lonicerae 45-65 gram, Semen arachidis hypogaeae 170 grams, 49 grams, Ovum Gallus domesticus album and white sugar 36 grams.

Embodiment 5:

Treat child's Chinese medicine formula of acute sinusitis, form by the raw material of Chinese medicine of following formula and weight: 47 grams, Radix Glycyrrhizae, Herba Menthae 28 grams, Flos Magnoliae 23 grams, Radix Scutellariae 39 grams, Fructus Forsythiae 28 grams, Bulbus Lilii 22 grams, Radix Trichosanthis 36 grams, Radix Salviae Miltiorrhizae 25 grams, Flos Lonicerae 36 grams, the Radix Angelicae Dahuricae 39 grams, the Radix Paeoniae Alba 20 grams, Herba Plantaginis 43 grams, Rhizoma Typhonii 33 grams, Spina Gleditsiae 39 grams, Caulis Lonicerae 65 grams, Semen arachidis hypogaeae 190 grams, 70 grams, Ovum Gallus domesticus album and white sugar 55 grams

Embodiment 6:

Treat child's Chinese medicine formula of acute sinusitis, the raw material of Chinese medicine composition by following formula and weight: 39 grams, Radix Glycyrrhizae, Herba Menthae 25 grams, Flos Magnoliae 18 grams, Radix Scutellariae 29 grams, Fructus Forsythiae 22 grams, Bulbus Lilii 16 grams, Radix Trichosanthis 29 grams, Radix Salviae Miltiorrhizae 20 grams, Flos Lonicerae 28 grams, the Radix Angelicae Dahuricae 32 grams, the Radix Paeoniae Alba 16 grams, Herba Plantaginis 41-43 gram, Rhizoma Typhonii 28 grams, Spina Gleditsiae 33 grams, Caulis Lonicerae 49 grams, Semen arachidis hypogaeae 175 grams, 55 grams, Ovum Gallus domesticus album and white sugar 39 grams.

Embodiment 7:

Treat child's Chinese medicine formula of acute sinusitis, the raw material of Chinese medicine composition by following formula and weight: 44 grams, Radix Glycyrrhizae, Herba Menthae 27 grams, Flos Magnoliae 20 grams, Radix Scutellariae 34 grams, Fructus Forsythiae 24 grams, Bulbus Lilii 20 grams, Radix Trichosanthis 32 grams, Radix Salviae Miltiorrhizae 22 grams, Flos Lonicerae 29 grams, the Radix Angelicae Dahuricae 34 grams, the Radix Paeoniae Alba 18 grams, Herba Plantaginis 43 grams, Rhizoma Typhonii 29 grams, Spina Gleditsiae 36 grams, Caulis Lonicerae 49-56 gram, Semen arachidis hypogaeae 185 grams, 65 grams, Ovum Gallus domesticus album and white sugar 49 grams

Embodiment 8:

Treat child's Chinese medicine formula of acute sinusitis, form by the raw material of Chinese medicine of following formula and weight: 42 grams, Radix Glycyrrhizae, Herba Menthae 26 grams, Flos Magnoliae 19 grams, Radix Scutellariae 32 grams, Fructus Forsythiae 23 grams, Bulbus Lilii 18 grams, Radix Trichosanthis 31 grams, Radix Salviae Miltiorrhizae 21 grams, Flos Lonicerae 29 grams, the Radix Angelicae Dahuricae 33 grams, the Radix Paeoniae Alba 17 grams, Herba Plantaginis 42 grams, Rhizoma Typhonii 29 grams, Spina Gleditsiae 34 grams, Caulis Lonicerae 53 grams, Semen arachidis hypogaeae 180 grams, 60 grams, Ovum Gallus domesticus album and white sugar 45 grams.

According to another aspect of the present invention, a kind of preparation method for the treatment of child's Chinese medicine formula of acute sinusitis is provided, it is characterized in that comprising the following steps:

Step one: get Herba Menthae 26 grams, Flos Magnoliae 19 grams, Radix Scutellariae 32 grams, Fructus Forsythiae 23 grams, Bulbus Lilii 18 grams and Radix Trichosanthis 31 grams of mix homogeneously, add 3-5 times of water gaging, reflux 4-5h, distillation, after collecting first time distillate, again distill 2-3h, after collecting second time distillate, merge distillate and second time distillate for the first time, extract volatile oil, for subsequent use;

Step 2: get Radix Salviae Miltiorrhizae 21 grams, Flos Lonicerae 29 grams, the Radix Angelicae Dahuricae 33 grams, the Radix Paeoniae Alba 17 grams, Herba Plantaginis 42 grams and Rhizoma Typhonii 29 grams of mix homogeneously, adds 3-6 times of micro-the boiling of water gaging and decocts 1-2h, filter, filtering residue adds 3-6 times of micro-the boiling of water gaging again and decocts 39-60min, filters, merging filtrate, extract filtrate, for subsequent use;

Step 3: get Spina Gleditsiae 34 grams, Caulis Lonicerae 53 grams and Radix Glycyrrhizae 42 grams of mix homogeneously, be ground into coarse powder, by percolation preparation, uses 49-70% ethanol as solvent, after dipping 23-37h, slowly percolation, treats that effective ingredient is filtered out completely, collects liquid of filtering, reclaim ethanol, extract liquid of filtering, for subsequent use;

Step 4: the liquid of filtering that extracts in the filtrate of extracting in combining step two and step 3, leave standstill 8-10h, filter, laying temperature, to 5-10 DEG C, adds the volatile oil extracted in step one, adds the water of 2-4 times amount, stir evenly, obtain the first mixture;

Step 5: get 60 grams, Ovum Gallus domesticus album and white sugar 45 grams of parts and put in bowl, stirs, is stirred to till becoming slurry always, makes syrup, described first mixture obtained is put into described syrup that step 5 makes and stir and become the second mixture in step 4;

Step 6: get Semen arachidis hypogaeae 180 grams and pour in described second mixture obtained in step 6, be stirred to described second mixture and be wrapped on described Semen arachidis hypogaeae crust, continues to stir, until temperature cools off, obtains finished product.

Chinese medicine claims acute sinusitis to be nasal sinusitis, refers to turbid nasal discharge, as the nether world and oozes, measures how more than cacorhinia for principal character." Plain Questions lose consciousness opinion " is said: " gallbladder-heat is moved in brain, then pungent volume nasal sinusitis.Nasal sinusitis person, rhinorrhea with turbid discharge also." nose is the key of lung, its pathological changes is many to be formed by wind and heat in the lung meridian.And nasal sinusitis duty in gallbladder person, it is that gallbladder arteries and veins arises from inner canthus because having three: one, after complications are distributed in brain, its gas leads in brain, and brain leads to again in cheek (bridge of the nose), therefore gallbladder internal organs has heat, on steam in brain, nasal sinusitis can be caused; Two is diet of people, and delicious food savoury, returns and gather in gallbladder, oozes, then retention of damp-heat in the interior if boldness can not disappear, if move heat in brain, is into nasal sinusitis; Three is passages through which vital energy circulates of liver, Yi You branch network in brain, liver and gallbladder phase the exterior and the interior, therefore liver and gall have heat, above move brain key, can cause nasal sinusitis.Children's's the lung being usually insufficient, lung opening at nose, therefore children's be comparatively grown up more be subject to exopathogen invasion and attack, criminal in nose; In addition children's is pure-yang constituent, the heresy of diseases caused by exogenous pathogenic factor very easily heat being transformed from excessive YANG and in entering.

Therefore, the traditional Chinese medical science thinks that the pathogeny of children's's nasal sinusitis mainly contains affection of exogenous wind-cold, wind heat, gallbladder heat stagnation, damp-heat in the spleen and stomach, several aspects such as lung qi deficiency and coldness, and children's's nasal sinusitis caused by gallbladder heat stagnation is clinical common, by " Plain Questions lose consciousness opinion ": " the gallbladder transferring pathogenic heat to the brain, then pungent peace nasal sinusitis.Nasal sinusitis person, rhinorrhea with turbid discharge also." because of the most aversion to wind of Lignum et Radix Naucleae evil, affection of exogenous wind-cold, wind heat, pathogenic factor in the exterior is not understood, and enters in gallbladder, also can Yu Ercheng heat.The liver sharing an interior-exterior relationship with the gallbladder, children's's " the liver being liable to excess ", gallbladder belongs to sun, and head is also positive, and gallbladder-heat can not be hidden for a long time, must move in heat and walk head.Brain is in head, and head, without the hot part in Tibetan, is met cave and namely entered, seek key and go out, and is along being tending towards nose, therefore, in treatment children acute sinusitis, to rush down clearly gallbladder-heat, removing toxic substances and promoting pus discharge, invigorating the lung and benefiting vital QI, a surname's clearing the nasal passage, is aided with blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema is the rule for the treatment of.

A kind of child's Chinese medicine formula for the treatment of acute sinusitis provided by the invention, the multiple Chinese medicine to the targeted composition for the treatment of acute sinusitis is selected to play mutual synergism, add Semen arachidis hypogaeae is adjuvant simultaneously, select raw Semen arachidis hypogaeae, without operations such as fryings, effectively kept the nutritional labeling in Semen arachidis hypogaeae, be more conducive to children taking.Gallbladder-heat can be rushed down clearly, removing toxic substances and promoting pus discharge, invigorating the lung and benefiting vital QI, treatment acute sinusitis, dispelling cold by warming the meridian, strong muscle are invigorated blood circulation, removing obstruction in the collateral to relieve pain effect, are treatment acute sinusitis special effect Chineses, for many years in clinical practice, cure the hundreds of example of patient, reliably evident in efficacy, mild in medicine property and, there is not toxic and side effects.Invention pharmaceutical formulation is reasonable, and preparation method is various, not only can simple and easy processing but also be applicable to factorial praluction, technique is simple, and medicine source is wide, and cost is low, taking convenience, good effect, to various suffer from a deficiency of the kidney evident in efficacy, mild in medicine property and, without any side effects, the present invention is through clinical application for many years, and effective percentage reaches 95%, cure rate 85%.

The clinical efficacy of Chinese medicine formula is summed up:

One, physical data: a kind of child's Chinese medicine formula for the treatment of acute sinusitis of the present invention, select the multiple Chinese medicine to the targeted composition for the treatment of acute sinusitis to play mutual synergism, add Semen arachidis hypogaeae is adjuvant simultaneously, is more conducive to children taking.Select raw Semen arachidis hypogaeae, without operations such as fryings, effectively kept the nutritional labeling in Semen arachidis hypogaeae, and the food that Semen arachidis hypogaeae is child to be liked, Semen arachidis hypogaeae fruit contains protein, fat, saccharide, vitamin A, vitamin B6, vitamin E, vitamin K, and the nutritional labeling such as mineral calcium, phosphorus, ferrum, the aminoacid containing 8 kinds of needed by human body and unsaturated fatty acid, containing materials such as lecithin, choline, carotene, crude fibres.Fat content is 44% ~ 45%, and protein content is 24 ~ 36%, and sugar content is about 20%.Containing abundant vitamin B2, PP, A, E, calcium and ferrum etc.And containing multivitamins such as thiamine, riboflavin, nicotinic acids.There is the brain cell development promoting child, the effect of hypermnesis.Gallbladder-heat can be rushed down clearly, removing toxic substances and promoting pus discharge, invigorating the lung and benefiting vital QI, treatment acute sinusitis, dispelling cold by warming the meridian, strong muscle are invigorated blood circulation, removing obstruction in the collateral to relieve pain effect, it is treatment children acute sinusitis special effect Chinese, for many years in clinical practice, cure the hundreds of example of patient, reliably evident in efficacy, mild in medicine property and, there is not toxic and side effects.

Present invention also offers a kind of using method for the treatment of child's Chinese medicine formula of acute sinusitis, every day 3 times, each 3,7 days 1 courses for the treatment of.

Two, toxicity test

Mice 50 (being provided by Nanjing laboratory animal and animal experimental center) is provided, female half and half, body weight 20 ~ 22g, at artificial lighting 12h, breeding observing 3 days in well-ventilated's situation, be divided into 5 groups at random, 10/group, wherein 1 group of white mice is blank group, three components does not gavage Chinese medicine formula prepared by the present invention in addition, the method of gavaging is and is dissolved in distilled water by Chinese medicine formula, be heated to 30 DEG C ~ 40 DEG C, stir and dissolve completely, the amount of gavaging is 15000mg/kg, fasting in 4h after 18h and administration before administration, but can't help water, observe the poisoning symptom of animal, analyse, observe the change of each histoorgan and core, liver, spleen, kidney, lung and intestinal do pathological section, calculate median lethal dose(LD 50), Continuous Observation 7 days, and note down.

After pouring into Chinese medicine composition with gastric perfusion needle is oral, individual mice is rolled up in corner, movable reduces, but the 2nd day observes, and 40 mice activities, drinks water and searches for food all normal.Continuous Observation is after 7 days, and 40 mices are all strong alive.The aspect such as spirit, appetite, the colour of skin, secretions, eye, breathing, muscular movement of whole mice, does not all observe ANOMALOUS VARIATIONS, catches and kills mice during off-test, and perusal internal organs change, different without obviously observing from 10 mices of blank group.According to toxicological evaluation standard, belong to non-toxic substance, and this test oral dose increases 15000mg/kg, 40 mices are still strong alive, and Chinese medicine composition Mixture on Mice safety non-toxic is described.

Long term toxicity test

Cavia porcellus 50 (being provided by Nanjing laboratory animal and animal experimental center) is provided, male and female half and half, body weight is 250g ~ 300g, be divided into five groups, often organize 10, wherein 1 group of white mice is blank group, and residue Four composition does not gavage Chinese medicine formula prepared by the present invention, and the amount of gavaging is 400mgkg ^-1, gavage 3 every day, the method of gavaging is and is dissolved in distilled water by Chinese medicine formula, be heated to 30 DEG C ~ 40 DEG C, stir and dissolve completely, the amount of gavaging is 15000mg/kg, fasting in 4h after 18h and administration before administration, but can't help water, successive administration 90 days, observe the growth promoter of animal, behavioral activity, feed water inlet, breathe, body temperature, hematuria is conventional, hepatic and renal function and other reactions, after last administration, blood extracting assay, put to death gross necropsy after animal and to the heart, liver, spleen, lung, the major organs such as kidney carry out check pathological section, medication has no the every observation index of more than laboratory animal on the 90th and does not occur abnormal change, or animal dead, different without obviously observing from matched group, animal carries out dissecting and does the inspection of each organs and tissues, be showed no abnormal pathologic to change.

Irritant experiment

Mice 40 (being provided by Nanjing laboratory animal and animal experimental center) is provided, female half and half, body weight 18 ~ 22g, is divided into four groups, wherein, one group as blank group, residue three components does not instill Chinese medicine formula prepared by the present invention in nasal cavity, and each 0.5ml, makes medicinal liquid contact at least 4h with the nasal mucosa of animal, then after 24h, put to death animal, take out local mucosa tissues and observe.Result shows, the nasal mucosa of this group laboratory animal without red and swollen, congested phenomenon, compared with naive animals, no significant difference, thus prove that Chinese medicine formula prepared by the present invention has no stimulation.

Skin allergy is tested

Cavia porcellus 40 (being provided by Nanjing laboratory animal and animal experimental center) is provided, male and female half and half, body weight is 250g ~ 300g, is fixed by Cavia porcellus, reject body surface 3 × 3cm by hair, the outer Chinese medicine formula being coated with the present invention and preparing respectively, every day 3 times, use 7 continuously, time result shows, skin allergy experiment, for negative, proves that nasal drop of the present invention can not produce anaphylaxis.

Zoopery

Rat (being provided by Nanjing laboratory animal and animal experimental center) is provided, chloral hydrate intraperitoneal injection of anesthesia, hair is shaved in bridge of the nose portion, hair place skin is shaved with suds are thoroughly clean, iodine tincture sterile working, ethanol takes off iodine, 2% lidocaine hydrochloride 0.1ml injects that nose center line position is subcutaneous makes infiltration anesthesia, along nose midline incision skin, otch is about 1.5cm, be separated left and right bone mucosa, expose two maxillary sinus antetheca district, cut left side maxillary sinus antetheca periosteum, expose analysis for maxillary sinus bony wall, bore careful boring with the gear division of diameter 2mm drill bit and open maxillary sinus antetheca, the fritter sterilized bio styptic cotton sheared in advance is filled in hole chamber from drill hole, get 0.2ml staphylococcus aureus suspension (1018 colony-forming units (colony-formingunits, CFU)/ml) slowly inject hole chamber, catgut suture periosteum, silk suture otch skin, modeling group started administration after 1 week.

Grouping and administration Cavia porcellus 30, male and female half and half, body weight is 250g ~ 300g, is divided into 3 groups at random, often organizes 10 (i.e. blank group, modeling group group and treatment groups.Except blank group, all the other respectively group all employing said method modelings.Each group of modeling started administration after 1 week, the powder 1 the present invention prepared is dissolved in distilled water, be heated to 30 DEG C ~ 40 DEG C, stir and dissolve completely, obtaining crude drug concentration is the solution of 1g/ml, and treatment group gavages this solution, continuous gavage 7 days, every day, the amount of gavage was 5ml/kg, every day model group and blank group every day with the normal saline gavage held with medication group etc.

Feeding and management

Rearing conditions: 28 DEG C, relative humidity 65%, freely drinks water, and single cage is raised, and adaptability is raised and within 1 week, started formal experiment.

Modeling result

After modeling the 3rd day, there is sneeze in part Cavia porcellus, nasal cavity has purulent secretion to overflow, nasal vestibule hydroderma or flushing, and skin of nose of scratching is frequent.Modeling is after 7 days, and all modeling Cavia porcelluss all occur above symptom and slightly poor with spirit, and drinking-water, dietary amount slightly reduce, the equal modeling success of each group.

Test index

From modeling the 2nd day, observe the behavior of animal, state, sign, amount of drinking water, situation of ingesting, defecation character, body temperature and weight, observe sniffle emphatically, nasal discharge has that it's too late amount, color, matter situation etc.After medication terminates, auricular vein gets blood, centrifugal, gets serum, and enzyme-linked method surveys IL-6 (interleukin-6) in each group of rabbit anteserum, CRP (c reactive protein) concentration.

Date processing

Measurement data adopts and represents, compare employing chi-square criterion between group, all data all adopt the process of SPSS12.0 statistical software.

Result

Each group of guinea pig serum IL-6 (interleukin-6), the impact of CRP (c reactive protein) concentration, the results are shown in Table 1.

Table 1 is group guinea pig serum IL-6, CRP concentration respectively affect unit ρ/pgL-1

Group n	IL-6	CRP
			Blank group 10	35.583±2.971	8.251±1.685
Model group 10	65.117±2.008	27.364±2.073
			Treatment group 10	37.292±1.696	9.013±1.334

Rhinorrhea symptom is there is not in blank group in whole experimentation, after Drug therapy, model group Cavia porcellus nasal cavity pyorrhea symptom is comparatively front without significant change, and adopt the nasal cavity pyorrhea symptom variation of the Cavia porcellus of traditional Chinese medicine composition for treating of the present invention remarkable, after treatment, close with matched group nasal cavity pyorrhea situation, thus prove, Chinese medicine formula of the present invention has good curative effect in treatment acute sinusitis.

Case of illness introduce:

1, model so-and-so, man, 12 years old, on April 10th, 2014 was medical with turbid nasal discharge 2 weeks, and before 2 weeks, this infant occurs rhinorrhea with clear discharge because suffering from cold, after transfer turbid tears to, once go to a doctor in department of otorhinolaryngology, give Western medicine external collunarium, have no improvement.Now see turbid nasal discharge, sticky and taste is smelly, companion be dizzy, headache, bitter taste, red tongue, thick, yellow and greasy fur.X-ray shows that frontal sinusitis sexually revises, and is diagnosed as " acute sinusitis ", Chinese medicine formula prepared by oral the present invention, 3 times/day, 3 tablets/time, within 7 days, is 1 course for the treatment of, treats 4 courses for the treatment of, recovery from illness, within 1 year, pays a return visit without relapsed acute sinusitis afterwards, does not have so far repeatedly

2, Lee, female, 11 years old, on July 1st, 2012 went to a doctor with turbid nasal discharge 1 week, and before 1 week, this infant occurs rhinorrhea with clear discharge because suffering from cold, after transfer turbid tears to, once go to a doctor in department of otorhinolaryngology, give Western medicine external collunarium, have no improvement.Now see turbid nasal discharge, sticky and taste is smelly, companion be dizzy, headache, bitter taste, red tongue, thick, yellow and greasy fur.Upper sinus frontalis tenderness (+), X-ray shows that frontal sinusitis sexually revises, and is diagnosed as " acute sinusitis ", Chinese medicine formula prepared by oral the present invention, 3 times/day, 3 tablets/time, within 7 days, is 1 course for the treatment of, treats 3 courses for the treatment of, recovery from illness, within 1 year, pays a return visit afterwards without recurrence.

3, Wei so-and-so, female, 15 years old.Because common cold treatment causes nose stream yellow thick nasal discharge amount many not in time, hyposmia, fever with chills, headache, cough with copious phlegm, is diagnosed as suppurative acute sinusitis.Take medicament 7 days prepared by Chinese medicine composition of the present invention, watery nasal discharge reduces, and transfer thin nasal discharge to by yellow thick nasal discharge, headache alleviates; Continue to take 14 days, nasal mucus is salubrious without, brains, and olfactory sensation recovers, and cures.Take the present invention to cure 3 courses for the treatment of, do not have so far repeatedly.

4, gold so-and-so, man, 18 years old.Property acute sinusitis, severe nasal blockage, impact sleep, headache, hypomnesis, has had a strong impact on studying and living.Take medicament 14 days prepared by Chinese medicine composition of the present invention, patient's nasal obstruction, headache syndromes disappear, and body constitution obviously strengthens, and memory is recovered and fully recovers.

5, Hu, female, 9 years old, acute sinusitis, took the present invention and cures, do not have so far repeatedly 3 courses for the treatment of.

6, Lee so-and-so, man, 25 years old, acute sinusitis, took the present invention and cures 4 courses for the treatment of, do not have so far repeatedly.

7, Wu so-and-so, man, 7 years old, acute sinusitis, took the present invention and cures 5 courses for the treatment of and do not have so far repeatedly.

Clinical data

One, patient data

All acute sinusitis infant comes from January, 2012 ~ 2013 year May, totally 200 examples.Be divided into 2 groups at random, treatment group 100 example, man 57 example, female 43 example; 6 ~ 12 years old age, average 8 years old; The course of disease 7 ~ 21 days, average 13 days.Matched group totally 100, man 49 example, female 51 example; 7 ~ 11 years old age, average 9 years old; The course of disease 7 ~ 20 days, average 14 days.

Two, usage and dosage: during clinical practice, the component in compositions, consumption take the circumstances into consideration increase and decrease according to the body weight of patient, age and symptom.Every day 3 times, each 3,7 days 1 courses for the treatment of, divide and take for early, middle and late three times.

Three, Therapeutic Method

Matched group: give regular western medicine treatment.Anti-infective therapy, symptom the lighter gives oral amoxicillin 25 ~ 40mg/ (kgd), and points 3 times are oral; Severe symptom gives intravenous drip penicillin 10 ~ 200,000 U/ (kgd), every day 1 ~ 2 time, or ceftriaxone sodium 60 ~ 80mg/ (kgd), every day 1 time; Macrolide antibiotics is given to penicillin or cephalosporins allergy sufferers, gives normal saline nasal cavity cleaning simultaneously, every day 1 time, 7 days 1 courses for the treatment of, continuous 3 courses for the treatment of.

Treatment group

Chinese medicine formula prepared by the oral the present invention of infant, every day 3 times, each 3,7 days 1 courses for the treatment of, divides and takes for early, middle and late three times, continuous 3 courses for the treatment of.

Four, criterion of therapeutical effect:

(1) cure: symptom, sign disappear completely, and nasal sinuses CT examination is normal;

(2) effective: nasal cavity pus tears obviously reduce, and have mild nasal congestion, the congested swelling of concha nasalis inferior disappears substantially, and nasal meatus has a small amount of glutinous pus tears, nasal sinuses CT examination, and compare with before treatment, hole chamber increase in density shadow scope obviously reduces;

(3) invalid: symptom, sign are substantially without improvement.

Group

Number of cases

Cure

Effectively

Invalid

Effectively total

Recurrence number

Relapse rate

					Rate (%)		(％)
								Treatment group	100	85	10	5	95	0	0
Matched group	100	50	20	30	70	20	28.5

Treatment group apparently higher than matched group, and is starkly lower than matched group in total effective rate in relapse rate, thus proves that Chinese medicine composition of the present invention has significant effect in treatment children acute sinusitis.And after experimenter links up, find children taking Chinese medicine formula of the present invention, not only there is no resentment, be happy on the contrary take, because the food that Semen arachidis hypogaeae is Most of children to be liked, not only considerably increase the misery of sufferer drug administration, and effectively can also treat acute sinusitis, reach 95% through long-term observation effective percentage of the present invention, cure rate 85%, is particularly suitable for children taking.

The above is only optimal way of the present invention; it should be pointed out that to those skilled in the art, without departing from the concept of the premise of the invention; can also make some similar distortion and improvement, these also should be considered as within protection scope of the present invention.

Claims (5)

1. treat child's Chinese medicine formula of acute sinusitis, it is characterized in that the raw material of Chinese medicine composition by following formula and weight: Radix Glycyrrhizae 36-49 gram, Herba Menthae 15-29 gram, Flos Magnoliae 10-25 gram, Radix Scutellariae 20-45 gram, Fructus Forsythiae 15-29 gram, Bulbus Lilii 10-25 gram, Radix Trichosanthis 20-45 gram, Radix Salviae Miltiorrhizae 15-27 gram, Flos Lonicerae 20-39 gram, Radix Angelicae Dahuricae 20-45 gram, Radix Paeoniae Alba 10-25 gram, Herba Plantaginis 36-49 gram, Rhizoma Typhonii 20-36 gram, Spina Gleditsiae 20-45 gram, Caulis Lonicerae 39-70 gram, Semen arachidis hypogaeae 129-195 gram, Ovum Gallus domesticus album 39-80 gram and white sugar 29-60 gram.

2. a kind of child's Chinese medicine formula for the treatment of acute sinusitis according to claim 1, is characterized in that the raw material of Chinese medicine composition by following formula and weight: Radix Glycyrrhizae 37-47 gram, Herba Menthae 20-28 gram, Flos Magnoliae 13-23 gram, Radix Scutellariae 25-39 gram, Fructus Forsythiae 18-28 gram, Bulbus Lilii 12-22 gram, Radix Trichosanthis 25-36 gram, Radix Salviae Miltiorrhizae 17-25 gram, Flos Lonicerae 25-36 gram, Radix Angelicae Dahuricae 25-39 gram, Radix Paeoniae Alba 15-20 gram, Herba Plantaginis 39-43 gram, Rhizoma Typhonii 23-33 gram, Spina Gleditsiae 29-39 gram, Caulis Lonicerae 45-65 gram, Semen arachidis hypogaeae 170-190 gram, Ovum Gallus domesticus album 49-70 gram and white sugar 36-55 gram.

3. a kind of child's Chinese medicine formula for the treatment of acute sinusitis according to claim 1, is characterized in that the raw material of Chinese medicine composition by following formula and weight: Radix Glycyrrhizae 39-44 gram, Herba Menthae 25-27 gram, Flos Magnoliae 18-20 gram, Radix Scutellariae 29-34 gram, Fructus Forsythiae 22-24 gram, Bulbus Lilii 16-20 gram, Radix Trichosanthis 29-32 gram, Radix Salviae Miltiorrhizae 20-22 gram, Flos Lonicerae 28-29 gram, Radix Angelicae Dahuricae 32-34 gram, Radix Paeoniae Alba 16-18 gram, Herba Plantaginis 41-43 gram, Rhizoma Typhonii 28-29 gram, Spina Gleditsiae 33-36 gram, Caulis Lonicerae 49-56 gram, Semen arachidis hypogaeae 175-185 gram, Ovum Gallus domesticus album 55-65 gram and white sugar 39-49 gram.

4. a kind of child's Chinese medicine formula for the treatment of acute sinusitis according to claim 1, is characterized in that the raw material of Chinese medicine composition by following formula and weight: 42 grams, Radix Glycyrrhizae, Herba Menthae 26 grams, Flos Magnoliae 19 grams, Radix Scutellariae 32 grams, Fructus Forsythiae 23 grams, Bulbus Lilii 18 grams, Radix Trichosanthis 31 grams, Radix Salviae Miltiorrhizae 21 grams, Flos Lonicerae 29 grams, the Radix Angelicae Dahuricae 33 grams, the Radix Paeoniae Alba 17 grams, Herba Plantaginis 42 grams, Rhizoma Typhonii 29 grams, Spina Gleditsiae 34 grams, Caulis Lonicerae 53 grams, Semen arachidis hypogaeae 180 grams, 60 grams, Ovum Gallus domesticus album and white sugar 45 grams.

5. a kind of preparation method for the treatment of child's Chinese medicine formula of acute sinusitis according to any one of claim 1-4, is characterized in that comprising the following steps:

Step one: get Herba Menthae, Flos Magnoliae, Radix Scutellariae, Fructus Forsythiae, Bulbus Lilii and Radix Trichosanthis mix homogeneously, add 3-5 times of water gaging, reflux 4-5h, distillation, after collecting first time distillate, again distill 2-3h, after collecting second time distillate, merge distillate and second time distillate for the first time, extract volatile oil, for subsequent use;

Step 2: get Radix Salviae Miltiorrhizae, Flos Lonicerae, the Radix Angelicae Dahuricae, the Radix Paeoniae Alba, Herba Plantaginis and Rhizoma Typhonii mix homogeneously, adds 3-6 times of micro-the boiling of water gaging and decocts 1-2h, filter, and filtering residue adds 3-6 times of micro-the boiling of water gaging again and decocts 39-60min, filters, merging filtrate, extracts filtrate, for subsequent use;

Step 3: get Spina Gleditsiae, Caulis Lonicerae and Radix Glycyrrhizae mix homogeneously, be ground into coarse powder, by percolation preparation, uses 49%-60% ethanol as solvent, and after dipping 23-37h, slowly percolation, treats that effective ingredient is filtered out completely, collects liquid of filtering, and reclaims ethanol, extracts liquid of filtering, for subsequent use;

Step 4: to filter liquid described in extracting in the described filtrate of extracting in combining step two and step 3, leave standstill 8-10h, filter, laying temperature, to 5-10 DEG C, adds the volatile oil extracted in step one, adds the water of 2-4 times amount, stir evenly, obtain the first mixture;

Step 5: get Ovum Gallus domesticus album and white sugar part is put in bowl, stirs, is stirred to till becoming slurry always, makes syrup, described first mixture obtained is put into described syrup that step 5 makes and stir and become the second mixture in step 4;

Step 6: get Semen arachidis hypogaeae and pour in described second mixture obtained in step 6, be stirred to described second mixture and be wrapped on described Semen arachidis hypogaeae crust, continues to stir, until temperature cools off, obtains finished product.