CN104606631A - Traditional Chinese medicine preparation for treating nasal polyp - Google Patents
Traditional Chinese medicine preparation for treating nasal polyp Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating nasal polyp. The preparation comprises the following raw materials by weight: 42 g of fructus xanthii, 26 g of mint, 19 g of fortune eupatorium herb, 32 g of lucid ganoderma, 23 g of fructus forsythia, 18 g of poria cocos, 31 g of wolfberries, 21 g of radix asparagi, 29 g of honeysuckle, 33 g of radix angelicae, 17 g of radix paeoniae alba, 42 g of acanthopanax, 29 g of radix curcumae, 34 g of kusnezoff aconite leaf, 53 g of honeysuckle stem, 176 g of walnut, 60 g of egg white and 45 g of honey. According to the traditional Chinese medicine preparation, a plurality of traditional Chinese medicine components with pertinence for treating nasal polyp are selected and used for taking synergistic interaction; meanwhile, the peanut serving as an auxiliary material is added. The traditional Chinese medicine preparation has the effects of resolving toxin and expelling pus, tonifying lung and replenishing qi, treating nasal polyp and activating meridians to stop pain. The traditional Chinese medicine preparation serves as a specific traditional Chinese medicine for treating nasal polyp and is remarkable and reliable in curative effect, mild in medicine property and free of toxic or side effects; the traditional Chinese medicine preparation is 95% in effective rate and 85% in cure rate.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to one and treat nasal polyp Chinese medicine formula.
Background technology
Nasal polyp is the superfluous lump being born in nasal cavity or sinus mucosa upper process, also known as nasal polyp, how because lung meridian is damp and hot, stops up caused by knot nose key, is apt to occur in lateral wall and the nose top of nasal cavity, and nasal polyp can cause nasal obstruction, it is obstructed to breathe, or the keying in flap valve sample; With olfactory disorder, have a headache, the symptom such as Hypernasality when speaking; The polypous medicine of current clinical treatment mostly is Western medicine and Chinese patent medicine, and be oral medicine or water preparation nose drops, oral medicine, likely containing hormone, should not use for a long time, some oral medicines are too strong to the contraction of blood vessel, life-time service easily develops immunity to drugs, and the course for the treatment of is longer, takes effect slow, have certain side effect to health; Water preparation nose drops, mobility is large, and be not easily attached on nasal membrane, life-time service easily causes the shortcomings such as vasomotor rhinitis.Treat polypous Chinese medicine preparation in the market of a great variety, but great majority also exist take effect slow, the course for the treatment of long, the easy shortcoming such as recurrence, bring larger misery and inconvenience to patient and there is no the Chinese medicine formula for child, needing improvement badly.
Summary of the invention
Object of the present invention provides one to treat nasal polyp Chinese medicine formula, solves one or more in above-mentioned prior art problem.
According to an aspect of the present invention, there is provided one to treat nasal polyp Chinese medicine formula, the raw material of Chinese medicine composition by following formula and weight: Fructus Xanthii 33-49 gram, Herba Menthae 16-29 gram, Herba Eupatorii 11-25 gram, Ganoderma 22-45 gram, Fructus Forsythiae 16-29 gram, Poria 11-25 gram, Fructus Lycii 22-45 gram, Radix Asparagi 16-27 gram, Flos Lonicerae 22-49 gram, Radix Angelicae Dahuricae 22-45 gram, Radix Paeoniae Alba 11-25 gram, Nidus Vespae 33-49 gram, Radix Curcumae 22-43 gram, Folium Aconiti Kusnezoffii 22-45 gram, Caulis Lonicerae 39-70 gram, Semen Juglandis 129-195 gram, Ovum Gallus domesticus album 39-76 gram and Mel 29-60 gram.
In some embodiments, by the raw material of Chinese medicine composition of following formula and weight: Fructus Xanthii 37-47 gram, Herba Menthae 22-28 gram, Herba Eupatorii 13-23 gram, Ganoderma 25-39 gram, Fructus Forsythiae 18-28 gram, Poria 12-22 gram, Fructus Lycii 25-33 gram, Radix Asparagi 17-25 gram, Flos Lonicerae 25-33 gram, Radix Angelicae Dahuricae 25-39 gram, Radix Paeoniae Alba 16-22 gram, Nidus Vespae 39-43 gram, Radix Curcumae 23-33 gram, Folium Aconiti Kusnezoffii 29-39 gram, Caulis Lonicerae 45-65 gram, Semen Juglandis 170-190 gram, Ovum Gallus domesticus album 49-70 gram and Mel 33-75 gram.
In some embodiments, by the raw material of Chinese medicine composition of following formula and weight: Fructus Xanthii 39-44 gram, Herba Menthae 25-27 gram, Herba Eupatorii 18-22 gram, Ganoderma 29-34 gram, Fructus Forsythiae 22-24 gram, Poria 16-22 gram, Fructus Lycii 29-32 gram, Radix Asparagi 22-22 gram, Flos Lonicerae 28-29 gram, Radix Angelicae Dahuricae 32-44 gram, Radix Paeoniae Alba 16-18 gram, Nidus Vespae 41-43 gram, Radix Curcumae 28-29 gram, Folium Aconiti Kusnezoffii 33-33 gram, Caulis Lonicerae 49-56 gram, Semen Juglandis 175-185 gram, Ovum Gallus domesticus album 55-65 gram and Mel 39-49 gram.
In some embodiments, form by the raw material of Chinese medicine of following formula and weight: Fructus Xanthii 42 grams, Herba Menthae 26 grams, Herba Eupatorii 19 grams, Ganoderma 32 grams, Fructus Forsythiae 23 grams, 18 grams, Poria, Fructus Lycii 31 grams, Radix Asparagi 21 grams, Flos Lonicerae 29 grams, the Radix Angelicae Dahuricae 33 grams, the Radix Paeoniae Alba 17 grams, 42 grams, Nidus Vespae, Radix Curcumae 29 grams, Folium Aconiti Kusnezoffii 34 grams, Caulis Lonicerae 53 grams, Semen Juglandis 176 grams, 60 grams, Ovum Gallus domesticus album and Mel 45 grams.
According to another aspect of the present invention, a kind of preparation method for the treatment of nasal polyp Chinese medicine formula is provided, it is characterized in that comprising the following steps:
Step one: get Herba Menthae, Herba Eupatorii, Ganoderma, Fructus Forsythiae, Poria and Fructus Lycii mix homogeneously, add 3-7 times of water gaging, reflux 4-5h, distillation, after collecting first time distillate, again distill 2-4h, after collecting second time distillate, merge distillate and second time distillate for the first time, extract volatile oil, for subsequent use;
Step 2: get Radix Asparagi, Flos Lonicerae, the Radix Angelicae Dahuricae, the Radix Paeoniae Alba, Nidus Vespae and Radix Curcumae mix homogeneously, adds 3-6 times of micro-the boiling of water gaging and decocts 1-2h, filter, and filtering residue adds 3-6 times of micro-the boiling of water gaging again and decocts 39-60min, filters, merging filtrate, extracts filtrate, for subsequent use;
Step 3: get Folium Aconiti Kusnezoffii, Caulis Lonicerae and Fructus Xanthii mix homogeneously, be ground into coarse powder, by percolation preparation, uses 40%-50% ethanol as solvent, after dipping 25-37h, slowly percolation, treats that effective ingredient is filtered out completely, collects liquid of filtering, reclaim ethanol, extract liquid of filtering, for subsequent use;
Step 4: the liquid of filtering that extracts in the filtrate of extracting in combining step two and step 3, leave standstill 8-11h, filter, laying temperature, to 15-25 DEG C, adds the volatile oil extracted in step one, adds the water of 2-4 times amount, stir evenly, obtain the first mixture;
Step 5: get Ovum Gallus domesticus album and Mel part is put in bowl, stirs, is stirred to till becoming slurry always, makes syrup, described first mixture obtained is put into described syrup that step 5 makes and stir and become the second mixture in step 4;
Step 6: get Semen Juglandis and pour in described second mixture obtained in step 6, be stirred to described second mixture and be wrapped on described walnut shell, continues to stir, until temperature cools off, obtains finished product.
This one treats nasal polyp Chinese medicine formula, and select the multiple Chinese medicine to the targeted composition of the chronic nasal polyp for the treatment of to play mutual synergism, add Semen Juglandis is adjuvant simultaneously, is more conducive to taking.Expelling wind and removing dampness can be strengthened, treat chronic nasal polyp, dispelling cold by warming the meridian, strong muscle are invigorated blood circulation, removing obstruction in the collateral to relieve pain effect, it is the chronic nasal polyp special effect Chinese for the treatment of, for many years in clinical practice, cure the hundreds of example of patient, reliably evident in efficacy, mild in medicine property and, there is not toxic and side effects, effective percentage reaches 90%, cure rate 85%.
Detailed description of the invention
Embodiment 1:
One treats nasal polyp Chinese medicine formula, forms: Fructus Xanthii 33 grams, Herba Menthae 16 grams, Herba Eupatorii 11 grams, Ganoderma 22 grams, Fructus Forsythiae 16 grams, 11 grams, Poria, Fructus Lycii 22 grams, Radix Asparagi 16 grams, Flos Lonicerae 22 grams, the Radix Angelicae Dahuricae 22 grams, the Radix Paeoniae Alba 11 grams, 33 grams, Nidus Vespae, Radix Curcumae 22 grams, Folium Aconiti Kusnezoffii 22 grams, Caulis Lonicerae 39 grams, Semen Juglandis 129 grams, 39 grams, Ovum Gallus domesticus album and Mel 29 grams by the raw material of Chinese medicine of following formula and weight.
Embodiment 2:
One treats nasal polyp Chinese medicine formula, forms: Fructus Xanthii 39 grams, Herba Menthae 23 grams, Herba Eupatorii 16 grams, Ganoderma 29 grams, Fructus Forsythiae 25 grams, 16 grams, Poria, Fructus Lycii 29 grams, Radix Asparagi 23 grams, Flos Lonicerae 29 grams, the Radix Angelicae Dahuricae 29 grams, the Radix Paeoniae Alba 16 grams, 45 grams, Nidus Vespae, Radix Curcumae 28 grams, Folium Aconiti Kusnezoffii 33 grams, Caulis Lonicerae 55 grams, Semen Juglandis 170 grams, 65 grams, Ovum Gallus domesticus album and Mel 49 grams by the raw material of Chinese medicine of following formula and weight.
Embodiment 3:
One treats nasal polyp Chinese medicine formula, forms: Fructus Xanthii 49 grams, Herba Menthae 29 grams, Herba Eupatorii 25 grams, Ganoderma 45 grams, Fructus Forsythiae 29 grams, 25 grams, Poria, Fructus Lycii 45 grams, Radix Asparagi 27 grams, Flos Lonicerae 39 grams, the Radix Angelicae Dahuricae 45 grams, the Radix Paeoniae Alba 25 grams, 49 grams, Nidus Vespae, Radix Curcumae 33 grams, Folium Aconiti Kusnezoffii 45 grams, Caulis Lonicerae 70 grams, Semen Juglandis 195 grams, 76 grams, Ovum Gallus domesticus album and Mel 60 grams by the raw material of Chinese medicine of following formula and weight
Embodiment 4:
One treats nasal polyp Chinese medicine formula, forms: Fructus Xanthii 37 grams, Herba Menthae 22 grams, Herba Eupatorii 13 grams, Ganoderma 25 grams, Fructus Forsythiae 18 grams, 12 grams, Poria, Fructus Lycii 25 grams, Radix Asparagi 17 grams, Flos Lonicerae 25 grams, the Radix Angelicae Dahuricae 25 grams, the Radix Paeoniae Alba 16 grams, 39 grams, Nidus Vespae, Radix Curcumae 23 grams, Folium Aconiti Kusnezoffii 29 grams, Caulis Lonicerae 45 grams, Semen Juglandis 170 grams, 49 grams, Ovum Gallus domesticus album and Mel 33 grams by the raw material of Chinese medicine of following formula and weight.
Embodiment 5:
One treats nasal polyp Chinese medicine formula, forms: Fructus Xanthii 47 grams, Herba Menthae 28 grams, Herba Eupatorii 23 grams, Ganoderma 39 grams, Fructus Forsythiae 28 grams, 22 grams, Poria, Fructus Lycii 33 grams, Radix Asparagi 25 grams, Flos Lonicerae 33 grams, the Radix Angelicae Dahuricae 39 grams, the Radix Paeoniae Alba 22 grams, 43 grams, Nidus Vespae, Radix Curcumae 33 grams, Folium Aconiti Kusnezoffii 39 grams, Caulis Lonicerae 65 grams, Semen Juglandis 190 grams, 70 grams, Ovum Gallus domesticus album and Mel 75 grams by the raw material of Chinese medicine of following formula and weight.
Embodiment 6:
One treats nasal polyp Chinese medicine formula, forms: Fructus Xanthii 39 grams, Herba Menthae 25 grams, Herba Eupatorii 18 grams, Ganoderma 29 grams, Fructus Forsythiae 22 grams, 16 grams, Poria, Fructus Lycii 29 grams, Radix Asparagi 22 grams, Flos Lonicerae 28 grams, the Radix Angelicae Dahuricae 32 grams, the Radix Paeoniae Alba 16 grams, 41 grams, Nidus Vespae, Radix Curcumae 28 grams, Folium Aconiti Kusnezoffii 33 grams, Caulis Lonicerae 49 grams, Semen Juglandis 175 grams, 55 grams, Ovum Gallus domesticus album and Mel 39 grams by the raw material of Chinese medicine of following formula and weight.
Embodiment 7:
One treats nasal polyp Chinese medicine formula, forms: Fructus Xanthii 44 grams, Herba Menthae 27 grams, Herba Eupatorii 22 grams, Ganoderma 34 grams, Fructus Forsythiae 24 grams, 22 grams, Poria, Fructus Lycii 32 grams, Radix Asparagi 22 grams, Flos Lonicerae 29 grams, the Radix Angelicae Dahuricae 44 grams, the Radix Paeoniae Alba 18 grams, 43 grams, Nidus Vespae, Radix Curcumae 29 grams, Folium Aconiti Kusnezoffii 33 grams, Caulis Lonicerae 56 grams, Semen Juglandis 185 grams, 65 grams, Ovum Gallus domesticus album and Mel 49 grams by the raw material of Chinese medicine of following formula and weight
Embodiment 8:
One treats nasal polyp Chinese medicine formula, forms: Fructus Xanthii 42 grams, Herba Menthae 26 grams, Herba Eupatorii 19 grams, Ganoderma 32 grams, Fructus Forsythiae 23 grams, 18 grams, Poria, Fructus Lycii 31 grams, Radix Asparagi 21 grams, Flos Lonicerae 29 grams, the Radix Angelicae Dahuricae 33 grams, the Radix Paeoniae Alba 17 grams, 42 grams, Nidus Vespae, Radix Curcumae 29 grams, Folium Aconiti Kusnezoffii 34 grams, Caulis Lonicerae 53 grams, Semen Juglandis 176 grams, 60 grams, Ovum Gallus domesticus album and Mel 45 grams by the raw material of Chinese medicine of following formula and weight.
According to another aspect of the present invention, a kind of preparation method for the treatment of nasal polyp Chinese medicine formula is provided, it is characterized in that comprising the following steps:
Step one: get Herba Menthae 26, Herba Eupatorii 19 grams, Ganoderma 32 grams, Fructus Forsythiae 23 grams, 18 grams, Poria and Fructus Lycii 31 grams of mix homogeneously, add 3-7 times of water gaging, reflux 4-5h, distillation, after collecting first time distillate, again distill 2-4h, after collecting second time distillate, merge distillate and second time distillate for the first time, extract volatile oil, for subsequent use;
Step 2: get Radix Asparagi 21 grams, Flos Lonicerae 29 grams, the Radix Angelicae Dahuricae 33 grams, the Radix Paeoniae Alba 17 grams, 42 grams, Nidus Vespae and Radix Curcumae 29 grams of mix homogeneously, adds 3-6 times of micro-the boiling of water gaging and decocts 1-2h, filter, filtering residue adds 3-6 times of micro-the boiling of water gaging again and decocts 39-60min, filters, merging filtrate, extract filtrate, for subsequent use;
Step 3: get Folium Aconiti Kusnezoffii 34 grams, Caulis Lonicerae 53 grams and Fructus Xanthii 42 grams of mix homogeneously, be ground into coarse powder, by percolation preparation, uses 40%-50% ethanol as solvent, after dipping 25-37h, slowly percolation, treats that effective ingredient is filtered out completely, collects liquid of filtering, reclaim ethanol, extract liquid of filtering, for subsequent use;
Step 4: the liquid of filtering that extracts in the filtrate of extracting in combining step two and step 3, leave standstill 8-11h, filter, laying temperature, to 15-25 DEG C, adds the volatile oil extracted in step one, adds the water of 2-4 times amount, stir evenly, obtain the first mixture;
Step 5: get 60 grams, Ovum Gallus domesticus album and Mel part 45 grams and put in bowl, stirs, is stirred to till becoming slurry always, makes syrup, described first mixture obtained is put into described syrup that step 5 makes and stir and become the second mixture in step 4;
Step 6: get Semen Juglandis 176 grams and pour in described second mixture obtained in step 6, be stirred to described second mixture and be wrapped on described walnut shell, continues to stir, until temperature cools off, obtains finished product.
One provided by the invention treats nasal polyp Chinese medicine formula, and select the multiple Chinese medicine to the targeted composition of the chronic nasal polyp for the treatment of to play mutual synergism, add Semen Juglandis is adjuvant simultaneously, is more conducive to taking.Expelling wind and removing dampness can be strengthened, treat chronic nasal polyp, dispelling cold by warming the meridian, strong muscle are invigorated blood circulation, removing obstruction in the collateral to relieve pain effect, are the chronic nasal polyp special effect Chineses for the treatment of, for many years in clinical practice, cure the hundreds of example of patient, reliably evident in efficacy, mild in medicine property and, there is not toxic and side effects.Invention pharmaceutical formulation is reasonable, and preparation method is various, not only can simple and easy processing but also be applicable to factorial praluction, technique is simple, and medicine source is wide, and cost is low, taking convenience, good effect, to various suffer from a deficiency of the kidney evident in efficacy, mild in medicine property and, without any side effects, the present invention is through clinical application for many years, and effective percentage reaches 90%, cure rate 85%.
The clinical efficacy of Chinese medicine formula is summed up:
One, physical data: one of the present invention treats nasal polyp Chinese medicine formula, select the multiple Chinese medicine to the targeted composition for the treatment of nasal polyp to play mutual synergism, add Semen Juglandis is adjuvant simultaneously, is more conducive to taking.Semen Juglandis is the food liked, and normal food can health invigorating, profit flesh, supplementing the brain, black beard and hair.Eat diuresis more, go five hemorrhoid that the Semen Persicae meat smashed to pieces and Fructus Piperis powder are put into pore, can black wool be grown.Semen Juglandis incinerates and Colophonium grinds, and can apply the tuberculosis of cervical lymph nodes and fester.Eating Semen Juglandis in addition makes people whet the appetite, and logical profit blood vessels, kindred is fine and smooth.Benefiting qi and nourishing blood, moistening the lung and resolving the phlegm, the beneficial gate of vitality, profit three is burnt, warming the lung intestine moistening, control deficiency and coldness breathe heavily cough, the heavy pain of waist lower limb, trusted subordinate's colic, dysentery hemorrhoidal hamorrhage, loosely swell and ache, send out variola, copper processed is malicious.With Fructus Psoraleae honeyed pill clothes, mend the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.Control damage, calculus of urethra.Eat the people that acid causes tooth shortcake, chew carefully Semen Juglandis and just can separate.Adhere to eating weekly twice Semen Juglandis, the danger of suffering from type 2 diabetes mellitus reduces by 24%.And containing a kind of composition reducing arteriosclerosis, allow tremulous pulse keep soft in Semen Juglandis, also containing antioxidant and alpha-linolenic acid, these all can protect nitrogen oxide, just protect tremulous pulse, contribute to healthy.Can not eat after children's's acute diseases such as cholera and sunstroke rash, must avoid half a year, not then can laxation, dysentery be not more than.Polyphagia moves phlegm retention, make people feel sick, guttation, tell food.Also can wind symptom, de-people's eyebrow.With wine overfeeding, people can be made to spit blood.But it should be noted that: Semen Juglandis is tonifying YANG, but carninomatosis people does not eat; Otherwise lump can be grown up.Gallbladder-heat can be rushed down clearly, removing toxic substances and promoting pus discharge, invigorating the lung and benefiting vital QI, treatment nasal polyp, dispelling cold by warming the meridian, strong muscle are invigorated blood circulation, removing obstruction in the collateral to relieve pain effect, are treatment child nasal polyp special effect Chineses, for many years in clinical practice, cure the hundreds of example of patient, reliably evident in efficacy, mild in medicine property and, there is not toxic and side effects.
Present invention also offers a kind of using method for the treatment of nasal polyp Chinese medicine formula, every day 3 times, each 3,7 days 1 courses for the treatment of.
Two, toxicity test
Mice 40 (being provided by Suzhou City's laboratory animal and animal experimental center) is provided, female half and half, body weight 20 ~ 22g, at artificial lighting 12h, breeding observing 3 days in well-ventilated's situation, be divided into 5 groups at random, 10/group, wherein 1 group of white mice is blank group, three components does not gavage Chinese medicine formula prepared by the present invention in addition, the method of gavaging is and is dissolved in distilled water by Chinese medicine formula, be heated to 30 DEG C ~ 40 DEG C, stir and dissolve completely, the amount of gavaging is 15000mg/kg, fasting in 4h after 18h and administration before administration, but can't help water, observe the poisoning symptom of animal, analyse, observe the change of each histoorgan and core, liver, spleen, kidney, lung and intestinal do pathological section, calculate median lethal dose(LD 50), Continuous Observation 7 days, and note down.
After pouring into Chinese medicine composition with gastric perfusion needle is oral, individual mice is rolled up in corner, movable reduces, but the 2nd day observes, and 30 mice activities, drinks water and searches for food all normal.Continuous Observation is after 7 days, and 30 mices are all strong alive.The aspect such as spirit, appetite, the colour of skin, secretions, eye, breathing, muscular movement of whole mice, does not all observe ANOMALOUS VARIATIONS, catches and kills mice during off-test, and perusal internal organs change, different without obviously observing from 10 mices of blank group.According to toxicological evaluation standard, belong to non-toxic substance, and this test oral dose increases 15000mg/kg, 40 mices are still strong alive, and Chinese medicine composition Mixture on Mice safety non-toxic is described.
Long term toxicity test
Cavia porcellus 40 (being provided by Suzhou City's laboratory animal and animal experimental center) is provided, male and female half and half, body weight is 200g ~ 250g, be divided into five groups, often organize 10, wherein 1 group of white mice is blank group, and residue Four composition does not gavage Chinese medicine formula prepared by the present invention, and the amount of gavaging is 400mgkg
-1, gavage 3 every day, the method of gavaging is and is dissolved in distilled water by Chinese medicine formula, be heated to 30 DEG C ~ 40 DEG C, stir and dissolve completely, the amount of gavaging is 15000mg/kg, fasting in 4h after 18h and administration before administration, but can't help water, successive administration 90 days, observe the growth promoter of animal, behavioral activity, feed water inlet, breathe, body temperature, hematuria is conventional, hepatic and renal function and other reactions, after last administration, blood extracting assay, put to death gross necropsy after animal and to the heart, liver, spleen, lung, the major organs such as kidney carry out check pathological section, medication has no the every observation index of more than laboratory animal on the 90th and does not occur abnormal change, or animal dead, different without obviously observing from matched group, animal carries out dissecting and does the inspection of each organs and tissues, be showed no abnormal pathologic to change.
Irritant experiment
Mice 20 (being provided by Suzhou City's laboratory animal and animal experimental center) is provided, female half and half, body weight 18 ~ 22g, is divided into four groups, wherein, one group as blank group, residue three components does not instill Chinese medicine formula prepared by the present invention in nasal cavity, and each 0.5ml, makes medicinal liquid contact at least 4h with the nasal mucosa of animal, then after 24h, put to death animal, take out local mucosa tissues and observe.Result shows, the nasal mucosa of this group laboratory animal without red and swollen, congested phenomenon, compared with naive animals, no significant difference, thus prove that Chinese medicine formula prepared by the present invention has no stimulation.
Skin allergy is tested
Cavia porcellus 30 (being provided by Suzhou City's laboratory animal and animal experimental center) is provided, male and female half and half, body weight is 250g ~ 300g, is fixed by Cavia porcellus, reject body surface 3 × 3cm by hair, the outer Chinese medicine formula being coated with the present invention and preparing respectively, every day 3 times, use 7 continuously, time result shows, skin allergy experiment, for negative, proves that nasal drop of the present invention can not produce anaphylaxis.
Zoopery
Rat (being provided by Suzhou City's laboratory animal and animal experimental center) is provided, chloral hydrate intraperitoneal injection of anesthesia, hair is shaved in bridge of the nose portion, hair place skin is shaved with suds are thoroughly clean, iodine tincture sterile working, ethanol takes off iodine, 2% lidocaine hydrochloride 0.1ml injects that nose center line position is subcutaneous makes infiltration anesthesia, along nose midline incision skin, otch is about 1.5cm, be separated left and right bone mucosa, expose two maxillary sinus antetheca district, cut left side maxillary sinus antetheca periosteum, expose analysis for maxillary sinus bony wall, bore careful boring with the gear division of diameter 2mm drill bit and open maxillary sinus antetheca, the fritter sterilized bio styptic cotton sheared in advance is filled in hole chamber from drill hole, get 0.2ml staphylococcus aureus suspension (1018 colony-forming units (colony-formingunits, CFU)/ml) slowly inject hole chamber, catgut suture periosteum, silk suture otch skin, modeling group started administration after 1 week.
Grouping and administration Cavia porcellus 30, male and female half and half, body weight is 250g ~ 300g, is divided into 3 groups at random, often organizes 10 (i.e. blank group, modeling group group and treatment groups.Except blank group, all the other respectively group all employing said method modelings.Each group of modeling started administration after 1 week, the powder 1 the present invention prepared is dissolved in distilled water, be heated to 30 DEG C ~ 40 DEG C, stir and dissolve completely, obtaining crude drug concentration is the solution of 1g/ml, and treatment group gavages this solution, continuous gavage 7 days, every day, the amount of gavage was 5ml/kg, every day model group and blank group every day with the normal saline gavage held with medication group etc.
Feeding and management
Rearing conditions: 30 DEG C, relative humidity 60%, freely drinks water, and single cage is raised, and adaptability is raised and within 1 week, started formal experiment.
Modeling result
After modeling the 3rd day, there is sneeze in part Cavia porcellus, nasal cavity has purulent secretion to overflow, nasal vestibule hydroderma or flushing, and skin of nose of scratching is frequent.Modeling is after 7 days, and all modeling Cavia porcelluss all occur above symptom and slightly poor with spirit, and drinking-water, dietary amount slightly reduce, the equal modeling success of each group.
Test index
From modeling the 2nd day, observe the behavior of animal, state, sign, amount of drinking water, situation of ingesting, defecation character, body temperature and weight, observe sniffle emphatically, nasal discharge has that it's too late amount, color, matter situation etc.After medication terminates, auricular vein gets blood, centrifugal, gets serum, and enzyme-linked method surveys IL-6 (interleukin-6) in each group of rabbit anteserum, CRP (c reactive protein) concentration.
Date processing
Measurement data adopts and represents, compare employing chi-square criterion between group, all data all adopt the process of SPSS12.0 statistical software.
Result
Each group of guinea pig serum IL-6 (interleukin-6), the impact of CRP (c reactive protein) concentration, the results are shown in Table 1.
Table 1 is group guinea pig serum IL-6, CRP concentration respectively
affect unit ρ/pgL-1
Group n | IL-6 | CRP |
Blank group 10 | 35.583±2.971 | 6.751±1.635 |
Model group 10 | 66.117±2.508 | 25.664±2.373 |
Treatment group 10 | 42.292±2.096 | 9.513±1.434 |
Rhinorrhea symptom is there is not in blank group in whole experimentation, after Drug therapy, model group Cavia porcellus nasal cavity pyorrhea symptom is comparatively front without significant change, and adopt the nasal cavity pyorrhea symptom variation of the Cavia porcellus of traditional Chinese medicine composition for treating of the present invention remarkable, after treatment, close with matched group nasal cavity pyorrhea situation, thus prove, Chinese medicine formula of the present invention has good curative effect in treatment nasal polyp.
Case of illness introduce:
1, Zhao so-and-so, female, 13 years old.Because common cold treatment causes nose stream yellow thick nasal discharge amount many not in time, hyposmia, fever with chills, headache, cough with copious phlegm, is diagnosed as suppurative nasal polyp.Take medicament 7 days prepared by Chinese medicine composition of the present invention, watery nasal discharge reduces, and transfer thin nasal discharge to by yellow thick nasal discharge, headache alleviates; Continue to take 14 days, nasal mucus is salubrious without, brains, and olfactory sensation recovers, and cures.Take the present invention to cure 3 courses for the treatment of, do not have so far repeatedly
2, Hu, man, 12 years old, on March 10th, 2013 was medical with turbid nasal discharge 2 weeks, and before 2 years, this infant occurs rhinorrhea with clear discharge because suffering from cold, after transfer turbid tears to, once go to a doctor in department of otorhinolaryngology, give Western medicine external collunarium, have no improvement.Now see turbid nasal discharge, sticky and taste is smelly, companion be dizzy, headache, bitter taste, red tongue, thick, yellow and greasy fur.X-ray shows that frontal sinusitis sexually revises, and is diagnosed as " chronic nasal polyp ", Chinese medicine formula prepared by oral the present invention, 3 times/day, 3 tablets/time, within 7 days, is 1 course for the treatment of, treats 5 courses for the treatment of, recovery from illness, within 1 year, pays a return visit afterwards without recurrence nasal polyp, does not have so far repeatedly.
3, go into business certain, female, 15 years old, on May 1st, 2013 goes to a doctor with turbid nasal discharge 1 week, and before 2 years, this infant occurs rhinorrhea with clear discharge because suffering from cold, after transfer turbid tears to, once go to a doctor in department of otorhinolaryngology, give Western medicine external collunarium, have no improvement.Now see turbid nasal discharge, sticky and taste is smelly, companion be dizzy, headache, bitter taste, red tongue, thick, yellow and greasy fur.Upper sinus frontalis tenderness (+), X-ray shows that frontal sinusitis sexually revises, and is diagnosed as " chronic nasal polyp ", Chinese medicine formula prepared by oral the present invention, 3 times/day, 3 tablets/time, within 7 days, is 1 course for the treatment of, treats 5 courses for the treatment of, recovery from illness, within 1 year, pays a return visit afterwards without recurrence.
4, Ma, man, 9 years old.Chronic nasal polyp, severe nasal blockage, impact sleep, headache, hypomnesis, has had a strong impact on studying and living.Take medicament 14 days prepared by Chinese medicine composition of the present invention, patient's nasal obstruction, headache syndromes disappear, and body constitution obviously strengthens, and memory is recovered and fully recovers.
5, Wu so-and-so, female, 12 years old, chronic nasal polyp, took the present invention and cures 7 courses for the treatment of, do not have so far repeatedly.
6, Lee so-and-so, man, 17 years old, chronic nasal polyp, took the present invention and cures 8 courses for the treatment of, do not have so far repeatedly.
7, Zheng, man, 24 years old, chronic nasal polyp, taking the present invention's 10 healings courses for the treatment of did not have repeatedly so far.
Clinical data
One, patient data
Whole nasal polyp infant comes from January, 2013 ~ 2014 year February, totally 200 examples.Be divided into 2 groups at random, treatment group 100 example, man 43 example, female 57 example; 20 ~ 25 years old age, average 23 years old; The course of disease 7 ~ 21 days, average 13 days.Matched group totally 100, man 49 example, female 51 example; 7 ~ 11 years old age, average 9 years old; The course of disease 7 ~ 20 days, average 14 days.
Two, usage and dosage: during clinical practice, the component in compositions, consumption take the circumstances into consideration increase and decrease according to the body weight of patient, age and symptom.Every day 3 times, each 3,7 days 1 courses for the treatment of, divide and take for early, middle and late three times.
Three, Therapeutic Method
Matched group: give regular western medicine treatment.Anti-infective therapy, symptom the lighter gives oral amoxicillin 20 ~ 40mg/ (kgd), and points 3 times are oral; Severe symptom gives intravenous drip penicillin 10 ~ 200,000 U/ (kgd), every day 1 ~ 2 time, or ceftriaxone sodium 50 ~ 80mg/ (kgd), every day 1 time; Macrolide antibiotics is given to penicillin or cephalosporins allergy sufferers, gives normal saline nasal cavity cleaning simultaneously, every day 1 time, 7 days 1 courses for the treatment of, continuous 3 courses for the treatment of.
Treatment group
Chinese medicine formula prepared by the oral the present invention of infant, every day 3 times, each 3,7 days 1 courses for the treatment of, divides and takes for early, middle and late three times, continuous 3 courses for the treatment of.
Four, criterion of therapeutical effect:
(1) cure: symptom, sign disappear completely, and nasal sinuses CT examination is normal;
(2) effective: nasal cavity pus tears obviously reduce, and have mild nasal congestion, the congested swelling of concha nasalis inferior disappears substantially, and nasal meatus has a small amount of glutinous pus tears, nasal sinuses CT examination, and compare with before treatment, hole chamber increase in density shadow scope obviously reduces;
(3) invalid: symptom, sign are substantially without improvement.
Treatment group apparently higher than matched group, and is starkly lower than matched group in total effective rate in relapse rate, thus proves that Chinese medicine composition of the present invention has significant effect in treatment child nasal polyp.And after experimenter links up, Chinese medicine formula of the present invention is taken in discovery, not only there is no resentment, be happy on the contrary take, because the food that Semen Juglandis is great majority to be liked, not only considerably increases the misery of sufferer drug administration, and can also effectively treat chronic nasal polyp, 90% is reached, cure rate 85% through long-term observation effective percentage of the present invention.Be particularly suitable for children taking.
The above is only optimal way of the present invention; it should be pointed out that to those skilled in the art, without departing from the concept of the premise of the invention; can also make some similar distortion and improvement, these also should be considered as within protection scope of the present invention.
Claims (5)
1. treat a nasal polyp Chinese medicine formula, it is characterized in that the raw material of Chinese medicine composition by following formula and weight: Fructus Xanthii 33-49 gram, Herba Menthae 16-29 gram, Herba Eupatorii 11-25 gram, Ganoderma 22-45 gram, Fructus Forsythiae 16-29 gram, Poria 11-25 gram, Fructus Lycii 22-45 gram, Radix Asparagi 16-27 gram, Flos Lonicerae 22-49 gram, Radix Angelicae Dahuricae 22-45 gram, Radix Paeoniae Alba 11-25 gram, Radix Et Caulis Acanthopanacis Senticosi 33-49 gram, Radix Curcumae 22-43 gram, Folium Aconiti Kusnezoffii 22-45 gram, Caulis Lonicerae 39-70 gram, Semen Juglandis 129-195 gram, Ovum Gallus domesticus album 39-76 gram and Mel 29-60 gram.
2. one treats nasal polyp Chinese medicine formula according to claim 1, it is characterized in that the raw material of Chinese medicine composition by following formula and weight: Fructus Xanthii 37-47 gram, Herba Menthae 22-28 gram, Herba Eupatorii 13-23 gram, Ganoderma 25-39 gram, Fructus Forsythiae 18-28 gram, Poria 12-22 gram, Fructus Lycii 25-33 gram, Radix Asparagi 17-25 gram, Flos Lonicerae 25-33 gram, Radix Angelicae Dahuricae 25-39 gram, Radix Paeoniae Alba 16-22 gram, Radix Et Caulis Acanthopanacis Senticosi 39-43 gram, Radix Curcumae 23-33 gram, Folium Aconiti Kusnezoffii 29-39 gram, Caulis Lonicerae 45-65 gram, Semen Juglandis 170-190 gram, Ovum Gallus domesticus album 49-70 gram and Mel 33-75 gram.
3. one treats nasal polyp Chinese medicine formula according to claim 1, it is characterized in that the raw material of Chinese medicine composition by following formula and weight: Fructus Xanthii 39-44 gram, Herba Menthae 25-27 gram, Herba Eupatorii 18-22 gram, Ganoderma 29-34 gram, Fructus Forsythiae 22-24 gram, Poria 16-22 gram, Fructus Lycii 29-32 gram, Radix Asparagi 22-22 gram, Flos Lonicerae 28-29 gram, Radix Angelicae Dahuricae 32-44 gram, Radix Paeoniae Alba 16-18 gram, Radix Et Caulis Acanthopanacis Senticosi 41-43 gram, Radix Curcumae 28-29 gram, Folium Aconiti Kusnezoffii 33-33 gram, Caulis Lonicerae 49-56 gram, Semen Juglandis 175-185 gram, Ovum Gallus domesticus album 55-65 gram and Mel 39-49 gram.
4. one treats nasal polyp Chinese medicine formula according to claim 1, it is characterized in that the raw material of Chinese medicine composition by following formula and weight: Fructus Xanthii 42 grams, Herba Menthae 26 grams, Herba Eupatorii 19 grams, Ganoderma 32 grams, Fructus Forsythiae 23 grams, 18 grams, Poria, Fructus Lycii 31 grams, Radix Asparagi 21 grams, Flos Lonicerae 29 grams, the Radix Angelicae Dahuricae 33 grams, the Radix Paeoniae Alba 17 grams, Radix Et Caulis Acanthopanacis Senticosi 42 grams, Radix Curcumae 29 grams, Folium Aconiti Kusnezoffii 34 grams, Caulis Lonicerae 53 grams, Semen Juglandis 176 grams, 60 grams, Ovum Gallus domesticus album and Mel 45 grams.
5. a kind of preparation method for the treatment of nasal polyp Chinese medicine formula according to any one of claim 1-4, is characterized in that comprising the following steps:
Step one: get Herba Menthae, Herba Eupatorii, Ganoderma, Fructus Forsythiae, Poria and Fructus Lycii mix homogeneously, add 3-7 times of water gaging, reflux 4-5h, distillation, after collecting first time distillate, again distill 2-4h, after collecting second time distillate, merge distillate and second time distillate for the first time, extract volatile oil, for subsequent use;
Step 2: get Radix Asparagi, Flos Lonicerae, the Radix Angelicae Dahuricae, the Radix Paeoniae Alba, Radix Et Caulis Acanthopanacis Senticosi and Radix Curcumae mix homogeneously, adds 3-6 times of micro-the boiling of water gaging and decocts 1-2h, filter, and filtering residue adds 3-6 times of micro-the boiling of water gaging again and decocts 39-60min, filters, merging filtrate, extracts filtrate, for subsequent use;
Step 3: get Folium Aconiti Kusnezoffii, Caulis Lonicerae and Fructus Xanthii mix homogeneously, be ground into coarse powder, by percolation preparation, uses 40%-50% ethanol as solvent, after dipping 25-37h, slowly percolation, treats that effective ingredient is filtered out completely, collects liquid of filtering, reclaim ethanol, extract liquid of filtering, for subsequent use;
Step 4: to filter liquid described in extracting in the described filtrate of extracting in combining step two and step 3, leave standstill 8-11h, filter, laying temperature, to 15-25 DEG C, adds the volatile oil extracted in step one, adds the water of 2-4 times amount, stir evenly, obtain the first mixture;
Step 5: get Ovum Gallus domesticus album and Mel part is put in bowl, stirs, is stirred to till becoming slurry always, makes syrup, described first mixture obtained is put into described syrup that step 5 makes and stir and become the second mixture in step 4;
Step 6: get Semen Juglandis and pour in described second mixture obtained in step 6, be stirred to described second mixture and be wrapped on described walnut shell, continues to stir, until temperature cools off, obtains finished product.
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Publication number | Priority date | Publication date | Assignee | Title |
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CN1343513A (en) * | 2001-08-15 | 2002-04-10 | 李咸珠 | Chinese medicine for treating rhinitis and nasosinusitis |
CN101164613A (en) * | 2007-10-12 | 2008-04-23 | 闫改转 | Proprietary Chinese medicine for treating rhinitis |
CN102363039A (en) * | 2011-11-14 | 2012-02-29 | 王敬祥 | Chinese medicine for treating rhinitis |
CN102379959A (en) * | 2011-11-24 | 2012-03-21 | 王立琦 | Traditional Chinese herbal composite for curing rhinitis |
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2015
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1343513A (en) * | 2001-08-15 | 2002-04-10 | 李咸珠 | Chinese medicine for treating rhinitis and nasosinusitis |
CN101164613A (en) * | 2007-10-12 | 2008-04-23 | 闫改转 | Proprietary Chinese medicine for treating rhinitis |
CN102363039A (en) * | 2011-11-14 | 2012-02-29 | 王敬祥 | Chinese medicine for treating rhinitis |
CN102379959A (en) * | 2011-11-24 | 2012-03-21 | 王立琦 | Traditional Chinese herbal composite for curing rhinitis |
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