CN113876848A - Traditional Chinese medicine composition for treating nasosinusitis, application agent and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating nasosinusitis, application agent and preparation method thereof Download PDFInfo
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- CN113876848A CN113876848A CN202111260269.XA CN202111260269A CN113876848A CN 113876848 A CN113876848 A CN 113876848A CN 202111260269 A CN202111260269 A CN 202111260269A CN 113876848 A CN113876848 A CN 113876848A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating nasosinusitis, a patch and a preparation method thereof, and relates to the technical field of traditional Chinese medicines, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 9-30 parts of hibiscus leaves, 10-30 parts of honeysuckle stems, 15-50 parts of spreading hedyotis herbs, 9-30 parts of scutellaria baicalensis, 5-10 parts of magnolia flowers, 5-10 parts of cocklebur fruits, 9-30 parts of ligusticum wallichii, 9-30 parts of spina gleditsiae, 5-10 parts of rheum officinale and 1-5 parts of borneol; the preparation method comprises the steps of carrying out water extraction, drying and crushing on the traditional Chinese medicines, and adding excipients, honey and the like to prepare the plaster. The external application plaster for treating nasosinusitis, which is prepared by the raw material proportion and the method, has the effects of clearing away heat and toxic materials, inducing resuscitation with pungent and warm natures, expelling pus from inside the body, purging and expelling toxin and the like, directly reaches a focus by applying to Shenque point and Tiantu point through acupoint penetration, and induces resuscitation through nose, has good curative effect on nasosinusitis, is quick in effect taking and simple in use method, and can overcome the defects that oral medicines are slow in absorption and cannot directly reach the focus and the defect that western medicine targets are single.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating nasosinusitis, a patch and a preparation method thereof.
Background
Inflammation of one or more sinuses is known as sinusitis, and involved sinuses include: maxillary, ethmoid, frontal and sphenoid sinuses. The disease has high incidence rate in the population, and affects the life quality of patients. Sinusitis can be divided into acute sinusitis and chronic sinusitis. Acute sinusitis is often caused by upper respiratory tract infections, and bacterial and viral infections can be concurrent. Chronic sinusitis is more common than acute sinusitis, and usually involves multiple sinuses simultaneously. The course of acute sinusitis is less than 12 weeks, and is mainly manifested by persistent and severe upper respiratory tract infection symptoms, including nasal obstruction, purulent nasal discharge, headache, and the like. The course of chronic sinusitis is > 12 weeks. This disease was classified as mild and moderate/severe according to the Visual Analogue Scale (VAS) score of severity (10 cm): mild VAS0-4 cm; moderate/heavy weight is VAS5-10 cm.
The acupoint plaster belongs to the field of traditional Chinese medicine external treatment methods, and the traditional Chinese medicine acupoint application belongs to one of the traditional Chinese medicine external treatment methods. The Chinese medicine patch is prepared by adopting a specific Chinese medicine formula, is applied to human acupuncture points (the main acupuncture point is the Shenque acupuncture point) to directly stimulate the human acupuncture points, activates the immunity of the human body, enables the self-healing force of the organism to play a role and achieves the purpose of treating diseases.
Specifically, the traditional Chinese medicine composition can activate channels and collaterals, dredge blood vessels, improve microcirculation, dredge qi and blood, accelerate metabolism and facilitate the discharge and elimination of exogenous pathogenic factors (bacteria and viruses); is applied to the Shenque acupoint, namely the navel, to activate primordial qi, enhance immunity, enhance the self-healing force of systems such as the five viscera and six hollow organs, and ensure the body to recover to health.
The plaster is applied to Tiantu acupoint to directly stimulate the self-healing force of throat, trachea and lung, and is beneficial to eliminating inflammation of throat part and lung.
Modern researches show that when the acupuncture points are stimulated and the medicine permeation reaches a certain amount, the organism can generate non-specific benign stimulation to excite a physiological stress system in the organism, and the defense immune function of the organism is enhanced and the metabolism is accelerated through a series of regulation of nerve-endocrine-body fluid, so that the aim of promoting the disease to be cured is fulfilled.
Based on the problems, a traditional Chinese medicine composition for treating nasosinusitis, a plaster and a preparation method thereof are designed to solve the problems.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides a traditional Chinese medicine composition for treating nasosinusitis, a patch and a preparation method thereof.
In a first aspect, the invention discloses a traditional Chinese medicine composition for treating nasosinusitis, which adopts the following technical scheme:
a traditional Chinese medicine composition for treating nasosinusitis is prepared from the following raw materials in parts by weight: 9-30 parts of hibiscus leaf, 10-30 parts of honeysuckle stem, 15-50 parts of spreading hedyotis herb, 9-30 parts of scutellaria baicalensis, 5-10 parts of biond magnolia flower, 5-10 parts of cocklebur fruit, 9-30 parts of ligusticum wallichii, 9-30 parts of spina gleditsiae, 5-10 parts of rheum officinale and 1-5 parts of borneol.
Further, the feed additive is prepared from the following raw materials in parts by weight: 9 parts of cotton rose hibiscus leaves, 15 parts of honeysuckle stems, 15 parts of hedyotis diffusa, 9 parts of scutellaria baicalensis, 9 parts of biond magnolia flowers, 6 parts of ligusticum wallichii, 9 parts of cocklebur fruits, 9 parts of spina gleditsiae, 5 parts of rheum officinale and 1 part of borneol.
Further, the feed additive is prepared from the following raw materials in parts by weight: 10 parts of cotton rose hibiscus leaves, 10 parts of honeysuckle stems, 15 parts of spreading hedyotis herbs, 12 parts of scutellaria baicalensis, 9 parts of biond magnolia flowers, 6 parts of ligusticum wallichii, 5 parts of cocklebur fruits, 12 parts of spina gleditsiae, 7 parts of rheum officinale and 1 part of borneol.
Further, the feed additive is prepared from the following raw materials in parts by weight: 10 parts of cotton rose hibiscus leaves, 12 parts of honeysuckle stems, 15 parts of spreading hedyotis herbs, 10 parts of scutellaria baicalensis, 10 parts of biond magnolia flowers, 6 parts of ligusticum wallichii, 7 parts of cocklebur fruits, 10 parts of spina gleditsiae, 6 parts of rheum officinale and 1 part of borneol.
Further, the feed additive is prepared from the following raw materials in parts by weight: 9 parts of cotton rose hibiscus leaves, 10 parts of honeysuckle stems, 15 parts of hedyotis diffusa, 6 parts of scutellaria baicalensis, 10 parts of biond magnolia flowers, 10 parts of ligusticum wallichii, 10 parts of cocklebur fruits, 11 parts of spina gleditsiae, 6 parts of rheum officinale and 1 part of borneol.
In a second aspect, the invention discloses an acupoint application agent for treating nasosinusitis, which adopts the following technical scheme:
an acupoint application for treating nasosinusitis comprises any one of the traditional Chinese medicine compositions for treating nasosinusitis.
Further, the acupoint application agent is applied to the Shenque acupoint and the Tiantu acupoint.
In a third aspect, the invention discloses a preparation method of an acupoint application for treating nasosinusitis, which adopts the following technical scheme:
a preparation method of an acupoint application agent for treating nasosinusitis comprises the steps of carrying out water extraction, drying and crushing on the traditional Chinese medicine of the traditional Chinese medicine composition for treating nasosinusitis, adding an excipient, honey and the like, and preparing the application agent.
By adopting the technical scheme:
and (3) cotton rose hibiscus leaves: slightly pungent with cool nature; has the functions of clearing away the lung-heat, cooling blood, relieving swelling and expelling pus; can be used for treating cough due to lung heat, hypertrophic rhinitis, lymphadenitis, appendicitis, carbuncle, furuncle, abscess, acute otitis media, burn, scald, etc.
Li Shizhen: the long-rooted salvia herb has the special effects of combining leaves, flat qi, no cold, no heat, slightly pungent taste, smooth and sticky saliva and treating carbuncle swelling. The chronic ulcer is also named as Qingliang ointment, Qinglu powder and Tiehuan powder. It is indicated for all abscess, deep-rooted carbuncle, back, acute mastitis, malignant boil, whether it is formed or not, and not worn, and then it is applied to the affected area with hibiscus leaf, or root bark, or flower, or raw ground, or dry ground, mixed with honey, left in the middle, and dried, which is frequently changed. The beginners feel cool and feel pain and relieve swelling. Already formed, pus is accumulated and pus is discharged. If the wearer is already wearing, the pus is easy to be collected. "(compendium of materia Medica)
Yu Huang Yu: hibiscus mutabilis has the effects of clearing heat and dissipating, eliminating swelling and toxin, treating all sores and ulcers, and being quick and good in drinking. "(" Yu mountain Yao Jie (medical solution)
Honeysuckle stem: sweet and cold in nature and flavor, entering lung and stomach meridians; has the functions of clearing away heat and toxic material, dispelling wind and dredging collaterals; it is mainly used for treating febrile disease with fever, toxic heat and bloody dysentery, bacillary dysentery, carbuncle, suppurative sore, abscess, skin infection, furuncle, etc.
Hedyotis diffusa: sweet and light in flavor, cold and cool in nature, entering stomach, large intestine and small intestine meridians; the Chinese medicinal composition has the functions of clearing away heat and toxic materials, removing dampness and treating stranguria, and is a good medicament for clearing away heat and toxic materials; it can be used for treating carbuncle, suppurative sore, sore throat, jaundice due to damp-heat pathogen, urinary tract infection, calculus, venomous snake bite, and cancer.
Scutellaria baicalensis: the bitter taste and cold nature enter lung, gallbladder, spleen, large intestine and small intestine meridians; has the functions of clearing heat, drying dampness, purging fire, removing toxin, stopping bleeding and preventing miscarriage; it can be used for treating damp-warm syndrome, summer-heat dampness, damp-heat distention and fullness, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, epistaxis, carbuncle, suppurative sore, and threatened abortion.
Fructus xanthil: bitter, sweet, pungent and warm in nature, entering lung and liver meridians; the functions of dispersing wind-cold, relieving stuffy nose, dispelling wind-damp and relieving pain; can be used for treating wind-cold type common cold, nasosinusitis, rheumatalgia, rubella, pruritus, etc.
Ligusticum wallichii: pungent and warm in liver and gallbladder meridians; the functions of promoting qi circulation, relieving depression, dispelling pathogenic wind, removing dampness, promoting blood circulation and relieving pain; it is mainly used for treating wind-cold headache, dizziness, carbuncle, cellulitis, and pyocutaneous disease. The book Jing: stroke mainly enters brain headache; the bibliography: removing cold and excessive nasal discharge in brain; rihuazi Bencao: for treating wind, nose flood, back-related brain abscess, pus discharge and blood stasis; the chuanxiong rhizome tea powder from the local prescription: it is indicated for dizziness, headache due to over-wind, stuffy nose and heavy voice.
Spina gleditsiae: pungent in flavor and warm in nature, entering liver and stomach meridians; has the functions of detumescence, toxin expelling, pus discharge and disinsection; it is indicated for early carbuncle and deep-rooted carbuncle, or pus formed without ulceration, and is indicated for external treatment of scabies, tinea and leprosy. Compendium of materia Medica: "Zao jiao Ci thorn treats wind and kills parasites, and its action is the same as pod, but its sharpness directly reaches the diseased part, which is different ear. "(the summary of the present materia Medica): spina Gleditsiae, drawing out toxic materials and dispelling pathogenic wind. When the superficial abscess is not formed, it can be led to dissipate, and when it is broken, it can be led to the head and when it is broken, it can be led to the pus discharge. The first herb is the ulcer poison. Also, it is also considered as the leading point of opening the collaterals in the case of drastic wind-evil because it can also purge wind-heat and wind-toxicity in blood. "
Rhubarb: bitter and cold in nature; spleen, stomach, large intestine, liver, pericardium meridian entered; the functions of purgation and eliminating accumulation, clearing heat and purging fire, cooling blood and removing toxicity, removing stasis and stimulating the menstrual flow, promoting diuresis and eliminating jaundice; can be used for treating constipation due to excessive heat accumulation, hematemesis and epistaxis, conjunctival congestion and pharyngeal swelling, carbuncle, furuncle, intestinal abscess, and abdominal pain. Can lead the heat of the first and second sores and ulcers into the large intestine and discharge the heat out of the body, treating the upper diseases and the lower diseases and leading the pathogenic factors out.
Borneol: cold in nature and pungent and bitter in flavor; enter heart, spleen and lung meridians; has the functions of inducing resuscitation and refreshing mind, and clearing away heat and relieving pain. Belongs to the resuscitation inducing medicine; can be used for treating fever, coma, phlegm heat, summer-heat, apoplexy, infantile convulsion, various sores, carbuncle, swelling and pain, ulcer, scald, burn, sore throat, laryngopharyngitis, conjunctival congestion, swelling and pain, and aphtha of the mouth and tongue. The Shen Fang in the area of longevity: it is indicated for headache and brain pain. By means of its action of inducing resuscitation and opening orifices, the efficacy of the drug is guided to the nasal sinuses to play a role, and meanwhile, the heat accumulated in the nasal sinuses is guided to the outside by carbuncle toxin.
Compared with the prior art, the invention has the beneficial effects that:
the external application plaster for treating nasosinusitis, which is prepared by the raw material proportion and the method, has the effects of clearing away heat and toxic materials, inducing resuscitation with pungent and warm natures, expelling pus from inside the body, purging and expelling toxin and the like, directly reaches a focus by applying to Shenque point and Tiantu point through acupoint penetration, and induces resuscitation through nose, has good curative effect on nasosinusitis, is quick in effect taking and simple in use method, and can overcome the defects that oral medicines are slow in absorption and cannot directly reach the focus and the defect that western medicine targets are single.
Detailed Description
The technical solutions in the embodiments of the present invention will be described below clearly and completely in connection with the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
The invention discloses a traditional Chinese medicine composition for treating nasosinusitis, which is prepared from the following raw materials in parts by weight: 9-30 parts of hibiscus leaf, 10-30 parts of honeysuckle stem, 15-50 parts of spreading hedyotis herb, 9-30 parts of scutellaria baicalensis, 5-10 parts of biond magnolia flower, 5-10 parts of cocklebur fruit, 9-30 parts of ligusticum wallichii, 9-30 parts of spina gleditsiae, 5-10 parts of rheum officinale and 1-5 parts of borneol.
An acupoint application for treating nasosinusitis comprises the traditional Chinese medicine composition for treating nasosinusitis;
a Chinese medicinal composition for treating sinusitis is prepared by extracting with water, oven drying, pulverizing, adding excipient, and Mel, and making into patch.
The acupoint application agent prepared by the application acts on and is pasted on the Shenque acupoint and the Tiantu acupoint.
Example 1:
a traditional Chinese medicine composition for treating nasosinusitis is prepared from the following raw materials in parts by weight: 9 parts of cotton rose hibiscus leaves, 15 parts of honeysuckle stems, 15 parts of hedyotis diffusa, 9 parts of scutellaria baicalensis, 9 parts of biond magnolia flowers, 6 parts of ligusticum wallichii, 9 parts of cocklebur fruits, 9 parts of spina gleditsiae, 5 parts of rheum officinale and 1 part of borneol.
An acupoint application for treating nasosinusitis comprises the traditional Chinese medicine composition for treating nasosinusitis;
a Chinese medicinal composition for treating sinusitis is prepared by extracting with water, oven drying, pulverizing, adding excipient, and Mel, and making into patch.
The acupoint application agent for treating nasosinusitis of the invention is detailed in the clinical treatment conditions as follows:
the using method comprises the following steps:
the external patch is applied to the Shenque point and the Tiantu point, and the time of the patch for children is reduced by half after each patch is applied for 20 hours; one patch is applied to each acupoint every day, and 10 days is 1 course of treatment.
Use contraindications: it is contraindicated for skin allergy or skin injury.
And (3) evaluating the curative effect:
and (3) healing: the symptoms of nasosinusitis disappear, and no recurrence occurs within 1 year of follow-up visit;
remarkably: the symptoms of nasosinusitis are obviously relieved;
the method has the following advantages: the symptoms of nasosinusitis are relieved;
and (4) invalidation: the change before and after treatment is not large.
And (3) analyzing the curative effect:
the number of patients suffering from nasosinusitis is 135; the type of patient: acute sinusitis 15 cases, and chronic sinusitis 120 cases.
The course of the disease is as follows: 50 cases in 1-5 months, 40 cases in 6 months to 1 year, and 45 cases over 2 years.
Age group: 70 cases under 16 years old, 40 cases 16-30 years old, and 25 cases over 30 years old.
The treatment time is as follows: the shortest patient has 1 course, the longest patient has 6 courses, and the average number of courses is 4.
The treatment effect is as follows: 99 cases are cured clinically, 27 cases with obvious curative effect and 9 cases with unobvious curative effect.
The number of effective treatments was 126, and the number of ineffective treatments was 9.
The specific implementation principle of the invention is as follows:
the external application plaster for treating nasosinusitis, which is prepared by the raw material proportion and the method, has the effects of clearing away heat and toxic materials, inducing resuscitation with pungent and warm natures, expelling pus from inside the body, purging and expelling toxin and the like, directly reaches a focus by applying to Shenque point and Tiantu point through acupoint penetration, and induces resuscitation through nose, has good curative effect on nasosinusitis, is quick in effect taking and simple in use method, and can overcome the defects that oral medicines are slow in absorption and cannot directly reach the focus and the defect that western medicine targets are single.
Example 2:
the difference between the embodiment and the embodiment 1 is that the traditional Chinese medicine composition for treating nasosinusitis is prepared from the following raw materials in parts by weight: 10 parts of cotton rose hibiscus leaves, 10 parts of honeysuckle stems, 15 parts of hedyotis diffusa, 12 parts of scutellaria baicalensis, 9 parts of biond magnolia flowers, 6 parts of ligusticum wallichii, 5 parts of cocklebur fruits, 12 parts of spina gleditsiae, 7 parts of rheum officinale and 1 part of borneol.
Example 3:
the difference between the embodiment and the embodiment 1 is that the traditional Chinese medicine composition for treating nasosinusitis is prepared from the following raw materials in parts by weight: 10 parts of cotton rose hibiscus leaves, 12 parts of honeysuckle stems, 15 parts of hedyotis diffusa, 10 parts of scutellaria baicalensis, 10 parts of biond magnolia flowers, 6 parts of ligusticum wallichii, 7 parts of cocklebur fruits, 10 parts of spina gleditsiae, 6 parts of rheum officinale and 1 part of borneol.
Example 4:
the difference between the embodiment and the embodiment 1 is that the traditional Chinese medicine composition for treating nasosinusitis is prepared from the following raw materials in parts by weight: 9 parts of cotton rose hibiscus leaves, 10 parts of honeysuckle stems, 15 parts of hedyotis diffusa, 6 parts of scutellaria baicalensis, 10 parts of biond magnolia flowers, 10 parts of ligusticum wallichii, 10 parts of cocklebur fruits, 11 parts of spina gleditsiae, 6 parts of rheum officinale and 1 part of borneol.
Comparative example 1:
a traditional Chinese medicine composition for treating nasosinusitis is prepared from the following raw materials in parts by weight: 15 parts of honeysuckle stem, 15 parts of spreading hedyotis herb, 9 parts of baical skullcap root, 9 parts of biond magnolia flower, 6 parts of szechuan lovage rhizome, 9 parts of siberian cocklebur fruit, 9 parts of Chinese honeylocust spine, 5 parts of rhubarb and 1 part of borneol; an acupoint application for treating nasosinusitis comprises the traditional Chinese medicine composition for treating nasosinusitis, the specific preparation method is the same as that in example 1, compared with example 1, hibiscus leaves are not added, and the treatment effect is obviously reduced: long acting time, slow symptom improvement and low cure rate. The essential position of the medicine in the formula is shown, and the medicine plays a main role in treating nasosinusitis.
Comparative example 2:
a traditional Chinese medicine composition for treating nasosinusitis is prepared from the following raw materials in parts by weight: 9 parts of cotton rose hibiscus leaves, 15 parts of oldenlandia diffusa, 9 parts of scutellaria baicalensis, 9 parts of biond magnolia flowers, 6 parts of ligusticum wallichii, 9 parts of cocklebur fruits, 9 parts of spina gleditsiae, 5 parts of rheum officinale and 1 part of borneol; an acupoint application for treating nasosinusitis comprises the traditional Chinese medicine composition for treating nasosinusitis, the specific preparation method is the same as that in example 1, compared with example 1, honeysuckle stem is not added, and the treatment effect is obviously reduced: long acting time, slow symptom improvement and low cure rate.
Comparative example 3:
a traditional Chinese medicine composition for treating nasosinusitis is prepared from the following raw materials in parts by weight: 9 parts of cotton rose hibiscus leaves, 15 parts of honeysuckle stems, 9 parts of scutellaria baicalensis, 9 parts of biond magnolia flowers, 6 parts of ligusticum wallichii, 9 parts of cocklebur fruits, 9 parts of spina gleditsiae, 5 parts of rheum officinale and 1 part of borneol; an acupoint application for treating nasosinusitis comprises the traditional Chinese medicine composition for treating nasosinusitis, the specific preparation method is the same as that of example 1, and compared with example 1, the acupoint application is not added with oldenlandia diffusa, so that the treatment effect is obviously reduced: long acting time, slow symptom improvement and low cure rate.
Comparative example 4:
a traditional Chinese medicine composition for treating nasosinusitis is prepared from the following raw materials in parts by weight: 9 parts of cotton rose hibiscus leaves, 15 parts of honeysuckle stems, 15 parts of hedyotis diffusa, 9 parts of biond magnolia flowers, 6 parts of ligusticum wallichii, 9 parts of cocklebur fruits, 9 parts of spina gleditsiae, 5 parts of rheum officinale and 1 part of borneol; an acupoint application for treating nasosinusitis comprises the traditional Chinese medicine composition for treating nasosinusitis, the specific preparation method is the same as that in example 1, compared with example 1, the traditional Chinese medicine composition is not added with scutellaria baicalensis, and the treatment effect is obviously reduced: long acting time, slow symptom improvement and low cure rate.
Comparative example 5:
a traditional Chinese medicine composition for treating nasosinusitis is prepared from the following raw materials in parts by weight: 9 parts of cotton rose hibiscus leaves, 15 parts of honeysuckle stems, 15 parts of hedyotis diffusa, 9 parts of scutellaria baicalensis, 9 parts of biond magnolia flowers, 6 parts of ligusticum wallichii, 9 parts of cocklebur fruits, 9 parts of spina gleditsiae and 5 parts of rheum officinale; an acupoint application for treating nasosinusitis comprises the traditional Chinese medicine composition for treating nasosinusitis, the specific preparation method is the same as that in example 1, compared with example 1, borneol is not added, and the treatment effect is obviously reduced: long acting time, slow symptom improvement and low cure rate. Borneol serves as a transdermal agent and plays a role in the patch which is not negligible. Borneol not only has the functions of restoring consciousness and inducing resuscitation, but also has the functions of walking and permeating skin, and can be used for dredging acupuncture points and guiding various medicines to quickly reach the disease to play a role in treatment. In other words, borneol itself has no therapeutic effect on sinusitis, and the inflammation is eliminated by opening the channels of acupuncture points and meridians and collaterals, so that the main drug, namely anti-inflammatory drugs such as hibiscus leaves, can quickly reach the affected sinuses.
Typical cases are:
in case one, some Tang Dynasty, women, age 15, nasal obstruction, thick nasal discharge and dizziness of 6 months, nasosinusitis is detected in local hospitals, and the treatment effect of western medicines such as azithromycin and the like is not obvious; the western medicines are stopped, and the nasosinusitis is pasted and applied to the Shenque point and the Tiantu point for 12 hours, and one paste is pasted on each point every day. After being applied for 3 days, the nasal obstruction is relieved, and the nasal discharge becomes thin and reduced, and the dizziness is light; after the plaster is applied for 1 course of treatment, dizziness disappears, and nasal obstruction and nasal discharge are obviously reduced; continuously applying for 1 course of treatment, and relieving symptoms; and then the application is consolidated for 1 course of treatment. After 1 year, the patient is followed up, and has no nasal obstruction, running nose, dizziness and the like.
In case II, a patient with a certain disease, a woman in the age of 25, nasal obstruction, thick nasal discharge and forehead pain for 1 year, is diagnosed with nasosinusitis by local hospital examination, and is diagnosed with the disease by the unobvious treatment effect of western medicines such as pioneer, azithromycin and the like; the western medicines are stopped, and the nasosinusitis is pasted and applied to the Shenque point and the Tiantu point for 20 hours, and one paste is pasted on each point every day. After being applied for 5 days, the nasal obstruction is relieved, the nasal discharge becomes thin and reduced, and the headache is slightly reduced; after being applied for 1 course of treatment, the nasal obstruction and the nasal discharge are obviously relieved, and the headache is also moderate; continuously applying for 2 courses, and relieving symptoms; and then the application is consolidated for 1 course of treatment. After 1 year, the nasal obstruction, the nasal discharge, the headache and the like are not released.
In the description of the present invention, it is to be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," and the like are used in an orientation or positional relationship that is indicative of, or indicative of, but not limiting of, the present invention, merely for the convenience of describing and simplifying the description, and that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and equivalent substitutions or changes according to the technical solution and the inventive concept of the present invention should be covered by the scope of the present invention.
Claims (8)
1. The traditional Chinese medicine composition for treating nasosinusitis is characterized by being prepared from the following raw materials in parts by weight: 9-30 parts of hibiscus leaf, 10-30 parts of honeysuckle stem, 15-50 parts of spreading hedyotis herb, 9-30 parts of scutellaria baicalensis, 5-10 parts of biond magnolia flower, 5-10 parts of cocklebur fruit, 9-30 parts of ligusticum wallichii, 9-30 parts of spina gleditsiae, 5-10 parts of rheum officinale and 1-5 parts of borneol.
2. The acupoint application for treating nasosinusitis according to claim 1, which is prepared from the following raw materials in parts by weight: 9 parts of cotton rose hibiscus leaves, 15 parts of honeysuckle stems, 15 parts of hedyotis diffusa, 9 parts of scutellaria baicalensis, 9 parts of biond magnolia flowers, 6 parts of ligusticum wallichii, 9 parts of cocklebur fruits, 9 parts of spina gleditsiae, 5 parts of rheum officinale and 1 part of borneol.
3. The acupoint application for treating nasosinusitis according to claim 1, which is prepared from the following raw materials in parts by weight: 10 parts of cotton rose hibiscus leaves, 10 parts of honeysuckle stems, 15 parts of hedyotis diffusa, 12 parts of scutellaria baicalensis, 9 parts of biond magnolia flowers, 6 parts of ligusticum wallichii, 5 parts of cocklebur fruits, 12 parts of spina gleditsiae, 7 parts of rheum officinale and 1 part of borneol.
4. The acupoint application for treating nasosinusitis according to claim 1, which is prepared from the following raw materials in parts by weight: 10 parts of cotton rose hibiscus leaves, 12 parts of honeysuckle stems, 15 parts of hedyotis diffusa, 10 parts of scutellaria baicalensis, 10 parts of biond magnolia flowers, 6 parts of ligusticum wallichii, 7 parts of cocklebur fruits, 10 parts of spina gleditsiae, 6 parts of rheum officinale and 1 part of borneol.
5. The acupoint application for treating nasosinusitis according to claim 1, which is prepared from the following raw materials in parts by weight: 9 parts of cotton rose hibiscus leaves, 10 parts of honeysuckle stems, 15 parts of hedyotis diffusa, 6 parts of scutellaria baicalensis, 10 parts of biond magnolia flowers, 10 parts of ligusticum wallichii, 10 parts of cocklebur fruits, 11 parts of spina gleditsiae, 6 parts of rheum officinale and 1 part of borneol.
6. An acupoint application for treating nasosinusitis, which is characterized by comprising the traditional Chinese medicine composition for treating nasosinusitis according to any one of claims 1 to 5.
7. The acupoint application for treating nasosinusitis according to claim 6, wherein the acupoint application is applied to the Shenque acupoint and the Tiantu acupoint.
8. A preparation method of an acupoint plaster for treating nasosinusitis is characterized by comprising the traditional Chinese medicine composition for treating nasosinusitis according to any one of claims 1 to 5, and adding excipient, honey and the like into the traditional Chinese medicine composition after the traditional Chinese medicine is subjected to water extraction, drying and crushing to prepare the plaster.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398645A (en) * | 2014-11-14 | 2015-03-11 | 李建军 | Traditional Chinese medicine composition for treating rhinitis and nasosinusitis |
| CN104547501A (en) * | 2015-01-01 | 2015-04-29 | 任毅 | Children traditional Chinese medicine formula for treating acute nasosinusitis |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398645A (en) * | 2014-11-14 | 2015-03-11 | 李建军 | Traditional Chinese medicine composition for treating rhinitis and nasosinusitis |
| CN104547501A (en) * | 2015-01-01 | 2015-04-29 | 任毅 | Children traditional Chinese medicine formula for treating acute nasosinusitis |
Non-Patent Citations (2)
| Title |
|---|
| 张志明等: "联合应用中药制剂鼻通宁和禾邦鼻炎胶囊治疗慢性鼻窦炎的临床观察", 《中国中西医结合耳鼻咽喉科杂志》 * |
| 无名老熊: "【鼻炎根治秘笈】", 《HTTP://WWW.360DOC.COM/CONTENT/21/0907/13/39587278_994484410.SHTML》 * |
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