CN109452639A - A kind of preparation method of Chinese medicine and health food that alleviating menstrual period pain - Google Patents
A kind of preparation method of Chinese medicine and health food that alleviating menstrual period pain Download PDFInfo
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- CN109452639A CN109452639A CN201811422933.4A CN201811422933A CN109452639A CN 109452639 A CN109452639 A CN 109452639A CN 201811422933 A CN201811422933 A CN 201811422933A CN 109452639 A CN109452639 A CN 109452639A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The invention discloses a kind of preparation method of Chinese medicine and health food for alleviating menstrual period pain, the extracting method of each bulk pharmaceutical chemicals is water extraction and alcohol precipitation method, and granule or mixture is made.Mixture the preparation method comprises the following steps: take raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae by prescription portion rate, add water to cook 3 times, each 2h；Said extracted liquid is collected, filtration merges 3 extracting solutions, and filtrate is concentrated into a certain concentration, is cooled to room temperature, and is slowly added to the ethyl alcohol that mass percent is 95% and quickly stirs, makes alcohol content 80%, and 12h is placed in sealing, is centrifuged to obtain supernatant, recycles ethyl alcohol；Supernatant is collected, additives are added, constant volume is at certain volume, filtration, packing, sterilizing.Chinese medicine and health food of the invention is in good taste, safely and effectively, most of crowds is suitble to be used for a long time；Have the effect of significantly alleviating menstrual period pain, regulating the qi flowing in the channels blood, kidney tonifying, essence replenishing, blood-nourishing analgesic, warming channel and expelling cold, adjusting endocrine can be led to.
Description
Technical field
The invention belongs to food technology fields, particularly relate to a kind of Chinese medicine and health food of alleviation menstrual period pain
Preparation method.
Background technique
Menstruation is the normal physiological phenomena of Women of childbearing age, is Human Physiology development as a result, its appearance indicates women
The preliminary maturation of reproductive physiology function, has the primary condition bred.The generation of primary dysmenorrhea removes constitution, mental element
Outside, mainly related with Prostaglandin PGF2 alpha too high levels in patient's secretory endometrium.PGF2 α is under progestogen action
Secretory endometrium in synthesis, for receptor in uterine muscular, menstrual endometrium is broken, and PGF2 α is released,
Uterus muscle strong contraction is stimulated, intra-uterine pressure is increased, local blood flow is reduced, ischemic, anoxic, so as to cause pain.
Dysmenorrhea is common disease, frequently-occurring disease in clinical gynaecology, belongs to inferior health scope.The generation of dysmenorrhea appoints with punching, uterus
Cyclical physiological variation is closely related, and main pathogenesis is in perverse trend that volt or essence or blood element lose, rushes wantonly two arteries and veins gas before and after more value menstrual period
The physiological change of blood is hurried, causes the QI-blood circulation of uterus unsmooth, and general rule pain or uterus do not lose in supporting, not Rong Ze pain, therefore make
Dysmenorrhea breaking-out.Common parting has the card such as kidney qi loss, deficient qi and blood, qi depression to blood stasis, cold blood stasis and damp-heat accumulation, suitable apparatus
There are the Chinese medicine or Chinese prescription of logical regulating the qi flowing in the channels blood, kidney tonifying, essence replenishing, blood-nourishing analgesic, warming channel and expelling cold and other effects.
Traditional Chinese medicine thinks that the kidney being the origin of congenital constitution, and is the root of organ yin-yang, and kidney controlling essence storage, kidney essense evaporates kidney by kidney yang
Yin generates kidney qi, and kidney qi can subsidize, promote, coordinating the yin-yang of whole body internal organs, and determines the growth of human body, development, reproduction, declines
Old and dead life process.The growth and development of each process or warp, band, tire, the production of fail situation, especially women etc. are special
Physiology course it is normal whether, both depend on the prosperity and decline profit and loss of kidney essense and kidney qi.Theory of traditional Chinese medical science thinks, congenital deficiency of kidney-QI, or
Sexual strain fecund or prolonged illness are deficient, injure kidney qi, and then essence loses that blood is few, and deficiency is appointed in punching, is let out through promoting circulation of blood, and vessels of the uterus is more empty to kidney deficiency, lose in moistening
It supports, not Rong Ze pain, therefore makes dysmenorrhea.It therefore, all should be in terms of tonic kidney essense kidney qi to alleviate menstrual pain, prevention early ageing etc.
Start with conditioning.
Currently, the chemicals and biological products of commercially available menstruction regulating and pain relieving class point inhibit PGF2 α synthesis class (to belong to antipyretic-antalgic
Class drug), uterine leio muscular relaxation class and adjust vegetative nerve class, brufen, paracetamol, Semen daturae tablet, hydrobromic acid mountain
Scopolic acid, oryzanol etc. have preferable effect in anti-inflammatory and antalgic and in terms of eliminating menstrual dysphoria, but occur many bad anti-
It answers, such as constipation, interference sleep, dry skin, causes clinical application limited.Chinese traditional medicine is paid attention to transferring human body itself
Immunity adjusts human endocrine system, has advantageous advantage in terms of fighting dysmenorrhea, preventing anxiety and anti-aging, together
When have safely and effectively, the small feature of toxic side effect.If it is possible to develop, one kind is small with toxic side effect, curative effect is good
It gets well, can take for a long time, will have huge market to send out with the Chinese medicine and health food for alleviating menstrual pain, prevention early ageing and other effects
Open up potentiality.
Summary of the invention
The present invention provides a kind of Chinese medicine and health food of alleviation menstrual period pain to overcome the shortcomings of the prior art
Preparation method.
The present invention is achieved by the following technical solutions: a kind of preparation side of Chinese medicine and health food that alleviating menstrual period pain
Method, the bulk pharmaceutical chemicals of the Chinese medicine and health food mainly have raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae,
The extracting method of each bulk pharmaceutical chemicals is water extraction and alcohol precipitation method, and granule or mixture is made in the Chinese medicine and health food for alleviating menstrual period pain.
The preparation method that the present invention alleviates the Chinese medicine and health food granule of menstrual period pain includes the following steps:
A, raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae are taken by prescription portion rate, added water to cook 3 times,
Each 2h；
B, said extracted liquid is collected, filtration merges 3 extracting solutions, and filtrate is concentrated into a certain concentration, is cooled to room temperature, and delays
The slow ethyl alcohol that mass percent is added and is 95% simultaneously quickly stirs, and makes alcohol content 80%, and sealing places 12h, is centrifuged to obtain supernatant,
Recycle ethyl alcohol；
C, supernatant is collected, is dried under reduced pressure through 60 DEG C to dry cream, is crushed up to Chinese medical extract；
D, above-mentioned Chinese medical extract is taken, additives are added, is mixed, softwood is made with 80% ethyl alcohol, 10 mesh medicines is crossed and sieves, 60 DEG C of dryings,
Whole grain；Drying time is 3~5h, and the sieve of medicine used in whole grain is 10 meshes and 65 meshes；
E, it dispenses.
The preparation method that the present invention alleviates the Chinese medicine and health food mixture of menstrual period pain specifically comprises the following steps:
A, raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae are taken by prescription portion rate, added water to cook 3 times,
Each 2h；
B, said extracted liquid is collected, filtration merges 3 extracting solutions, and filtrate is concentrated into a certain concentration, is cooled to room temperature, and delays
The slow ethyl alcohol that mass percent is added and is 95% simultaneously quickly stirs, and makes alcohol content 80%, and sealing places 12h, is centrifuged to obtain supernatant,
Recycle ethyl alcohol；
C, supernatant is collected, additives are added, constant volume is at certain volume, filtration；
D, packing, sterilizing, sterilizing methods are boiling sterilization, flowing steam sterilization method or autoclaving.
The present invention alleviates the parts by weight of each bulk pharmaceutical chemicals in the Chinese medicine and health food of menstrual period pain are as follows: 1~10 part of raspberry, meat
1~8 part of cardamom, 1~8 part of mulberries, 1~8 part of peach kernel, 1~6 part of rhizoma polygonati, 1~6 part of radix polygonati officinalis, 1~6 part of Gorgon fruit and Radix Glycyrrhizae 1~4
Part,
As the preferred embodiment of the present invention, alleviate the parts by weight of each bulk pharmaceutical chemicals in the Chinese medicine and health food of menstrual period pain are as follows:
4~8 parts of raspberry, 3~5 parts of nutmeg, 3~5 parts of mulberries, 3~5 parts of peach kernel, 2~4 parts of rhizoma polygonati, 2~4 parts of radix polygonati officinalis, Gorgon fruit 2~
4 parts and 1~3 part of Radix Glycyrrhizae.
As preferred forms of the invention, alleviate the parts by weight of each bulk pharmaceutical chemicals in the Chinese medicine and health food of menstrual period pain
Are as follows: 6 parts of raspberry, 4 parts of nutmeg, 4 parts of mulberries, 4 parts of peach kernel, 3 parts of rhizoma polygonati, 3 parts of radix polygonati officinalis, 3 parts of Gorgon fruit and 2 parts of Radix Glycyrrhizae.
Decocting amount of water in step a for the first time is 8~12 times of above-mentioned each bulk pharmaceutical chemicals total weight, after twice amount of water be upper
6~10 times for stating each bulk pharmaceutical chemicals total weight.Preferably, decocting amount of water in step a for the first time is above-mentioned each bulk pharmaceutical chemicals total weight
10 times, after twice amount of water be 8 times of above-mentioned each bulk pharmaceutical chemicals total weight.The additives of addition are preservative or preservative and rectify
The mixture of taste agent.
The present invention is according to theory of traditional Chinese medical science reasonable compatibility raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and sweet
The medicinal material of 8 kinds of integration of drinking and medicinal herbs such as grass.Prescription has logical regulating the qi flowing in the channels blood, kidney tonifying, essence replenishing, blood-nourishing analgesic, warming channel and expelling cold effect, can be relieved
The unsmooth card of qi and blood caused by blood element lose and various diseases alleviates menstrual period pain, prevents anxiety, prevents early ageing, regulates and controls human body
Physiological function.Raspberry in the present invention invigorates the kidney and stops nocturnal emission establishing-Yang reducing urination, nourishes the liver to improve visual acuity as monarch drug in a prescription.Rhizoma polygonati, radix polygonati officinalis boosting qi and nourishing yin profit
Lung, Yishen Jianpi promote the production of body fluid to quench thirst as ministerial drug.Peach kernel promoting blood circulation, relax bowel and defecation；Gorgon fruit tonifying spleen clearing damp, supplementing the kidney to control the nocturnal；Mulberries are grown
Yin is enriched blood, and ease constipation is promoted the production of body fluid；Three is adjutant altogether.All the medicines share, and play kidney and spleen invigorating altogether, nourishing heart tonifying liver, QI invigorating righting is to dispel
Heresy, eliminating evil go just not hurt, and heresy removes the just disease amelioration or even to more from peace.It there is no identical as the present invention group in currently available technology
The document report of side and its preparation.
Raspberry: it is sweet can help, acid can restrain, warm-natured without scorching, kidney-replenishing and the disadvantage without impairment of yin, prevent prolapse and without sluggish
Evil, beneficial to the function of lower envelope hiding, be apt to control the card of kidney deficiency not admittedly and mending can be solid.Representative medicine of the raspberry as the establishing-Yang that invigorates the kidney and stops nocturnal emission,
Clinically it is usually used in treating neurasthenia, emission and spermatorrhea, premature ejaculation impotence, enuresis frequent micturition, consumptive disease, mesh is secretly dim-sighted to wait card.Pharmacology
It is demonstrated experimentally that raspberry has anti-mutagenesis, anti-inflammatory, anti-oxidant, improving studing ability, anti-aging and enhances immune etc. make
With.
Nutmeg: acrid flavour, it is warm-natured.Returns spleen, stomach, large intestine channel.Middle benefit gas promoting the circulation of qi, relieving diarrhea with astringents.For deficiency-cold in spleen and stomach, chronic diarrhea is not
Only, abdominal distention, deficiency of food vomiting." materia medica ": nutmeg, except cold eliminating dampness, taste are specially managed in promoting the circulation of qi of unhitching.
Mulberries: it is sweet in flavor, it is cold in nature.Return heart, liver and kidney channel.With nourishing yin and supplementing blood, ease constipation, the effect of promoting the production of body fluid.For yin deficiency blood
Void, the deficiency of Yin are quenched one's thirst, and body fluid deficiency is thirsty, dizziness and tinnitus, dry constipation of intestines.For dizziness caused by the yin deficiency deficiency of blood, tinnitus, mesh be dark, insomnia,
Poliosis is ground honeyed bolus processed with this product and is taken；Also can with the Chinese medicines such as the fleece-flower root, the fruit of glossy privet with using, the benefits of to enhance nourishing yin and supplementing blood,
Such as Shouwuyishoudan.
Peach kernel: bitter, it is mild-natured.Return heart, liver, lung, large intestine channel.With promoting blood circulation, the effect of relax bowel and defecation.For passing through
It closes, dysmenorrhea, postpartum stasis, injuries from falls as well, pulmonary abscess, acute appendicitis, dry constipation of intestines.For amenorrhea due to stagnation of blood, dysmenorrhea, often with safflower,
Radix Angelicae Sinensis, Chinese herbaceous peony are equally used, such as peach blossom Siwu Tang；For postpartum stasis abdominal pain, it can be equal with Radix Angelicae Sinensis, Rhizoma Chuanxiong, baked ginger and use, it is such as biochemical
Soup.
Rhizoma polygonati: it is sweet in flavor, it is mild-natured.Returns spleen, lung, kidney channel.With boosting qi and nourishing yin, the effect of invigorating the spleen, moistening lung, kidney-nourishing.For controlling
Treat deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, overstrain cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, palpus
Hair is early white, the card such as Heat Diabetes, is one of common nourishing drug of Chinese medicine.Modern research shows that rhizoma polygonati has resisting pathogenic microbes
Such as bacterium, fungi, virus, reducing blood lipid is hypoglycemic, blood pressure lowering, and anti-aging is antitumor, antifatigue, anti-radiation, resist oxygen lack, resists
Oxidation activity, enhancing is immune, and immune enhancing is the decline of the leucocyte due to caused by antagonism cyclophosphamide, and strong neutrophil gulps down
The effects of effect of biting, coronary artery dilator, increase coronary blood flow.
Radix polygonati officinalis: Shennong's Herbal is classified as top grade.It is sweet in flavor, cold nature.It attaches to the lung and stomach meridians.With nourishing yin to moisten dryness, promote the production of body fluid to quench thirst
The effect of.For treating lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, the card such as Heat Diabetes.Modern research shows that radix polygonati officinalis has
The effects of raising immunity, heart tonifying is hypoglycemic, reducing blood lipid, extends animal lifespan.
Gorgon fruit: it is sweet, puckery, it puts down.Returns spleen, kidney channel.With tonifying spleen clearing damp, the effect of supplementing the kidney to control the nocturnal.For splenasthenic diarrhea, kidney deficiency
Spermatorrhea, leukorrhagia.Gorgon fruit can be used together, such as yihuang decoction for controlling under humid tropics with heat-clearing and diuresis-promoting drugs such as Cortex Phellodendri, semen plantaginis；For spleen
The leukorrhagia of two void of kidney is mostly used together with reinforcing spleen and kidney medicines such as Radix Codonopsis, Rhizoma Atractylodis Macrocephalaes.
Radix Glycyrrhizae: sweet natured, return heart, spleen, lung, stomach meridian.With invigorating the spleen and benefiting qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain
The effect of, and can coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, stomach duct and abdomen, four limbs contraction are suddenly ached
Bitterly, carbuncle sore tumefacting virus alleviates the strong property of drug poison.
The beneficial effects of the present invention are: the present invention is based on the given efficacy of each natural plants and pharmaceutical values, with nature
Plant combines traditional health-preserving method with theory of medicine, is conceived to and alleviates menstrual period pain, anti-inflammatory and antalgic, adjusts endocrine
Deng by the plant optimization compounding of 8 kinds of integration of drinking and medicinal herbs such as raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae.
On the one hand, lead to regulating the qi flowing in the channels blood, kidney tonifying, essence replenishing, nourish body, it is empty must mend, canonical it is prosperous, immunity enhance；On the other hand, blood-nourishing analgesic,
Warming channel and expelling cold, palace is supported, ovary obtains warm, anti-aging.Congenital deficiency of kidney-QI or sexual strain fecund or prolonged illness are deficient, injure kidney
Gas, then essence loses that blood is few, and vessels of the uterus loses in supporting, therefore has dysmenorrhea to kidney deficiency.Chinese prescription of the invention can be relieved blood element lose and various
The unsmooth card of qi and blood caused by disease prevents anxiety, prevents early ageing, regulates and controls human body physiological function.
The present invention also provides a kind of Chinese medicine and health foods in terms of alleviating menstrual period pain, improving energy, anti-aging
Purposes.Raspberry in the present invention invigorates the kidney and stops nocturnal emission establishing-Yang reducing urination, nourishes the liver to improve visual acuity as monarch drug in a prescription.Rhizoma polygonati, radix polygonati officinalis boosting qi and nourishing yin moistening lung, benefit
Kidney and strengthening spleen promotes the production of body fluid to quench thirst as ministerial drug.Raspberry in the present invention invigorates the kidney and stops nocturnal emission establishing-Yang reducing urination, nourishes the liver to improve visual acuity as monarch drug in a prescription.Rhizoma polygonati, jade
Bamboo boosting qi and nourishing yin moistening lung, Yishen Jianpi promote the production of body fluid to quench thirst as ministerial drug.Peach kernel promoting blood circulation, relax bowel and defecation；Gorgon fruit tonifying spleen clearing damp, benefit
Kidney controlling nocturnal emission with astringent drugs；Mulberries nourishing yin and supplementing blood, ease constipation are promoted the production of body fluid；Three is adjutant altogether.All the medicines share, and play kidney and spleen invigorating altogether, and nourishing heart is mended
Liver, with eliminating evil, eliminating evil goes just not hurt for QI invigorating righting, and heresy removes the just disease amelioration or even to more from peace.
The Chinese medicine and health food that the present invention alleviates menstrual period pain also has the advantage that in good taste, safely and effectively, is suitble to big
Most crowds are used for a long time；Raw material all derives from integration of drinking and medicinal herbs Chinese medicine or natural food, safely and effectively, no ill-effect, nutrition
Comprehensively.The Chinese medicine and health food has the effect of significantly alleviating menstrual period pain, can lead to regulating the qi flowing in the channels blood, kidney tonifying, essence replenishing, blood-nourishing stop
Bitterly, warming channel and expelling cold, endocrine function is adjusted, is suitable for numerous women, is also applied for other sub-health populations.The present invention, which uses, to be covered
Basin, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and the extract mixtures of Radix Glycyrrhizae as raw material, be made granule or
Mixture, the granule or mixture have according to Basic Theories of Chinese Medicine prescription and alleviate menstrual period pain, adjust endocrine health care function
Can, can enriching yin and nourishing kidney, QI invigorating analgesia, menstruction regulating and pain relieving.The present invention has apparent remission effect, nothing to dysmenorrhea caused by estrogen
Obvious adverse reaction, no dependence, simple process is easy, and production cost is low, is conducive to industrialized production, can be made as needed
A variety of dosage forms.
Detailed description of the invention
Fig. 1 is schematic diagram of the granule to the analgesic activity of hot plate method induced pain mouse；
Fig. 2 is schematic diagram of the granule to the analgesic activity of glacial acetic acid induced pain mouse；
Fig. 3 is the linear dependence figure between absorbance A value and Evans blue seepage discharge；
Fig. 4 is the schematic diagram of influence of the granule to mouse capillary permeability；
Fig. 5 is that granule influences schematic diagram to mouse toes swelling；
Fig. 6 is influence schematic diagram of the granule to uterus activity ratio；
Fig. 7 is the linear dependence figure between absorbance OD value and β-ep amount；
Fig. 8 is influence schematic diagram of the granule to female mice β-ep content.
Specific embodiment
Below in conjunction with the drawings and specific embodiments, present invention is further described in detail, but not as to limit of the invention
System.
A kind of preparation method of Chinese medicine and health food that alleviating menstrual period pain, the bulk pharmaceutical chemicals of the Chinese medicine and health food mainly have
Raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae, the parts by weight of each bulk pharmaceutical chemicals are as follows: each bulk pharmaceutical chemicals mention
Taking method is water extraction and alcohol precipitation method, and granule or mixture is made in the Chinese medicine and health food for alleviating menstrual period pain.
The preparation method of granule of the present invention includes the following steps: a, takes raspberry, nutmeg, mulberry by prescription portion rate
Shen, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae add water to cook 3 times, each 2h；B, said extracted liquid, filtration, by 3 times are collected
Extracting solution merges, and filtrate is concentrated into a certain concentration, is cooled to room temperature, and is slowly added to the ethyl alcohol that mass percent is 95% and quick
Stirring makes alcohol content 80%, and 12h is placed in sealing, is centrifuged to obtain supernatant, recycles ethyl alcohol；C, supernatant is collected, is depressurized through 60 DEG C
Drying is crushed to dry cream up to Chinese medical extract；D, above-mentioned Chinese medical extract is taken, additives are added, is mixed, with 80% ethyl alcohol system
At softwood, 10 mesh medicines sieve, 60 DEG C of dryings, whole grain are crossed；Drying time is 3~5h, and the sieve of medicine used in whole grain is 10 meshes and 65 mesh
Sieve；E, it dispenses.
The preparation method of mixture of the present invention specifically comprises the following steps: a, takes raspberry, nutmeg, mulberry by prescription portion rate
Shen, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae add water to cook 3 times, each 2h；B, said extracted liquid, filtration, by 3 times are collected
Extracting solution merges, and filtrate is concentrated into a certain concentration, is cooled to room temperature, and is slowly added to the ethyl alcohol that mass percent is 95% and quick
Stirring makes alcohol content 80%, and 12h is placed in sealing, is centrifuged to obtain supernatant, recycles ethyl alcohol；C, supernatant is collected, additives are added,
Constant volume is at certain volume, filtration；D, packing, sterilizing, sterilizing methods are boiling sterilization, flowing steam sterilization method or pressure sterilizing
Method.
The present invention alleviates the parts by weight of each bulk pharmaceutical chemicals in the Chinese medicine and health food of menstrual period pain are as follows: 1~10 part of raspberry, meat
1~8 part of cardamom, 1~8 part of mulberries, 1~8 part of peach kernel, 1~6 part of rhizoma polygonati, 1~6 part of radix polygonati officinalis, 1~6 part of Gorgon fruit and Radix Glycyrrhizae 1~4
Part.As the preferred embodiment of the present invention, alleviate the parts by weight of each bulk pharmaceutical chemicals in the Chinese medicine and health food of menstrual period pain are as follows: cover
4~8 parts of basin, 3~5 parts of nutmeg, 3~5 parts of mulberries, 3~5 parts of peach kernel, 2~4 parts of rhizoma polygonati, 2~4 parts of radix polygonati officinalis, Gorgon fruit 2~4
Part and 1~3 part of Radix Glycyrrhizae.As preferred forms of the invention, alleviate each bulk pharmaceutical chemicals in the Chinese medicine and health food of menstrual period pain
Parts by weight are as follows: 6 parts of raspberry, 4 parts of nutmeg, 4 parts of mulberries, 4 parts of peach kernel, 3 parts of rhizoma polygonati, 3 parts of radix polygonati officinalis, 3 parts of Gorgon fruit and Radix Glycyrrhizae 2
Part.
Decocting amount of water in step a for the first time is 8~12 times of above-mentioned each bulk pharmaceutical chemicals total weight, after twice amount of water be upper
6~10 times for stating each bulk pharmaceutical chemicals total weight.Preferably, decocting amount of water in step a for the first time is above-mentioned each bulk pharmaceutical chemicals total weight
10 times, after twice amount of water be 8 times of above-mentioned each bulk pharmaceutical chemicals total weight.The additives of addition are preservative or preservative and rectify
The mixture of taste agent.
Embodiment 1: mixture.
Formula: raspberry 60g, nutmeg 40g, mulberries 40g, peach kernel 40g, rhizoma polygonati 30g, radix polygonati officinalis 30g, Gorgon fruit 30g, sweet
Careless 20g and sodium benzoate 0.6g.
Preparation method: taking raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae, adds water to cook 3 times,
Each 2h, first time amount of water are 12 times of above-mentioned raw materials total amount, after twice amount of water be 10 times of above-mentioned raw materials total amount.It collects
Extracting solution, filtration merge 3 extracting solutions, and filtrate is concentrated into a certain concentration, is cooled to room temperature, and are slowly added to mass concentration
For 95% ethyl alcohol and quickly stir, make alcohol content 75%, 12h is placed in sealing, is centrifuged to obtain supernatant, and additives, constant volume is added
At certain volume, filtration, packing, sterilizing.
Embodiment 2: granule.
Formula: raspberry 50g, nutmeg 30g, mulberries 40g, peach kernel 40g, rhizoma polygonati 30g, radix polygonati officinalis 30g, Gorgon fruit 20g, sweet
Careless 10g, dextrin 40 g, sucrose 80g and 80% ethyl alcohol 10mL.
Preparation method: taking raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae, adds water to cook 3 times,
Each 2h, each amount of water are 10 times of above-mentioned raw materials total amount.Extracting solution is collected, filtration merges extracting solution three times, filtrate
It is concentrated into a certain concentration, is cooled to room temperature, the ethyl alcohol that mass concentration is 95% is slowly added to and is quickly stirred, alcohol content is made
80%, 12h is placed in sealing, is centrifuged to obtain supernatant, is dried under reduced pressure through 60 DEG C to dry cream, is crushed, additives are added, mix, crosses 80 mesh
Sieve, using dry granulation, uniformly sprays into suitable 80% ethyl alcohol, and hand is made and pinches the i.e. scattered softwood of agglomerating, finger pressure, then with extruding
Mode is sieved by 10 mesh medicines, and uniform particle is made, is rapidly placed in the particle being prepared into 60 DEG C of baking oven, dry 3h.It takes
Dry particle carries out whole grain, packing with 10 meshes and 65 meshes.
Embodiment 3: mixture.
Formula: raspberry 60g, nutmeg 40g, mulberries 30g, peach kernel 30g, rhizoma polygonati 30g, radix polygonati officinalis 20g, Gorgon fruit 20g, Radix Glycyrrhizae
15g and ethylparaben 0.5g.The preparation method is the same as that of Example 1.
Embodiment 4: granule.
Formula: raspberry 70g, nutmeg 40g, mulberries 40g, peach kernel 20g, rhizoma polygonati 20g, radix polygonati officinalis 30g, Gorgon fruit 15g, sweet
Careless 15g, dextrin 90g, Steviosin 0.04g and 80% ethyl alcohol 10mL.Preparation method is the same as embodiment 2.
Chinese materia medica preparation in the present invention can alleviate menstrual period pain, delay senescence, and keep or enhance ovarian function, anti-inflammatory
The effect of analgesia, can be proved by following four pharmacodynamic experiment: experiment I: the analgesic experiment of hot plate method and writhing method；Experiment II:
The anti-inflammatory experiment of mice caused by dimethylbenzene xylene auricle edema method and the test of carrageenan induced mice pedal swelling；Experiment III: it receives in uterus
Contracting experiment；IV: serumβ-ep horizontal measurement experiment is tested, the specific implementation method respectively tested is as follows:
1. experimental material.
1.1, laboratory sample and reagent.
Bolus for woman diseases (Shanxi Guang Yuyuan traditional Chinese medicines Co., Ltd, lot number: 139170102)；Aspirin enteric coated tablet (Bayer medicine
Healthcare Corporation, lot number: BJ32400)；Yinhuang Particle (Hengsheng Pharmaceutical Co., Ltd., Zhongshan City, lot number: 20161007)；Penta
Sour estrogen tablet (DELPHARM Lille S.A.S, lot number H20160679)；The Tianjin NaCl(causes the remote limited public affairs of chemical reagent
Department, lot number: 20160710)；Evans blue (Shanghai Ru Ji biotechnology Development Co., Ltd, lot number: 150722)；Carrageenan
(Shanghai Mike's woods biochemical technology Co., Ltd, lot number: C10068972)；Methylene blue (the limited public affairs of Chinese medicines group chemical reagent
Department, lot number: 20151223)；Mouse β-ep kit (Tianjin An Nuoruikang Bioisystech Co., Ltd).
1.2, experimental animal.
SPF Kunming mice, male and female dual-purpose, 18~22g of weight are mentioned by Nanfang Medical Univ's Experimental Animal Center
For the Guangdong production licence number SCXK() 2016-0041, Guangdong pharmaceutical university Experimental Animal Center raising experiment.According to experimental
Matter and gender divide cage to feed, and drinking-water is freely eaten, weighs in every other day.22~24 DEG C of room temperature, relative humidity 52%~56%.
1.3, instrument and producer.
BP211D type a ten thousandth electronic balance (Mei Tele-support benefit Instrument Ltd.)；KQ-300DE numerical control ultrasound
Washer (Kunshan Ultrasonic Instruments Co., Ltd.)；(Community of Jin Tan County Jin Cheng state wins laboratory apparatus to six hole water-bath of HH-S6 constant temperature
Factory)；YLS-6B intelligence hot-plate instrument (Beijing Zhong Shidichuan development in science and technology Co., Ltd)；Top Pette8-Channer
The Pipettor liquid relief volley of rifle fire (the emerging wound laboratory apparatus Beijing Co., Ltd of big dragon)；MNT-150 Mei Naite origin digital display calliper (Shanghai
Mei Naite Industrial Co., Ltd.)；Thermo Scientific Multiskan Spectrum microplate reader (the silent winged generation that China of match
Co., Ltd)；Thermo Scientific HERA cell CO2 cell incubator (Co., Ltd in the silent winged generation that of match)；
BL-420F biological signal collecting and analysis system (Chengdu TME Technology Co., Ltd.)；FT-102N has calibrated tension sensor
(Chengdu TME Technology Co., Ltd.).
1.4, the preparation of sample.
Body weight in terms of 60kg, mouse daily dose in terms of 9 times of people, the mouse dosage of positive control drug with
0.2mL/10g meter, the mouse dosage of tested granule particle is in terms of 0.3mL/10g.Sample is specifically formulated as follows:
1. given the test agent is prepared: (50~60 DEG C) of physiological saline dissolutions are added in the granule being prepared into Example 2, necessary
Shi Jinhang ultrasonic treatment, is configured to the suspension of basic, normal, high three kinds of concentration (100mg, 150mg, 225mg:1mL).
2. the preparation of Yinhuang Particle sample (60mg:1mL): Yinhuang Particle mortar being ground in after powder, 6g is weighed and adds
Physiological saline is to 100mL, prepared before use.
3. the preparation of aspirin enteric coated tablet sample (4.5mg:1mL): it is in powder that aspirin enteric coated tablet mortar, which is ground,
It is last, it weighs 0.45g and adds physiological saline to 100mL, be ultrasonically treated when necessary, prepared before use.
4. the preparation of bolus for woman diseases sample (81mg:1mL): bolus for woman diseases mortar being ground in after powder, 3.24g is weighed and adds
(50~60 DEG C) physiological saline is ultrasonically treated, prepared before use to 40mL.
5. the preparation of Estradiol Valerate sample (0.04mg:1mL): a piece of estradiol valerate tablet (1mg/ piece) being taken to be dissolved in
In 25ml physiological saline, prepared before use.
6. 0.8% acetum: the glacial acetic acid of accurate measuring 0.8mL adds distilled water constant volume into the volumetric flask of 100mL, faces
With preceding preparation.
7. 0.5% Evans blue physiological saline: weighing 0.5g Evans blue powder and be completely dissolved in 100mL physiological saline, pass through
0.22 μm of miillpore filter filtration, prepared before use.
8. 0.8% acetic acid physiological saline: the glacial acetic acid of accurate measuring 0.8mL adds physiological saline constant volume to the volumetric flask of 100mL
In, prepared before use.
9. 1% carrageenan suspension: weighing 50mg carrageenan powder for 24 hours before use and be dissolved in 50mL physiological saline, repeatedly
Shaking is ultrasonically treated when necessary to no indissoluble object gel, is placed in 4 DEG C of preservations.
10. 5% methylene blue solution: weighing 0.5g methylene blue powder and be completely dissolved in the second that the mass concentration of 100mL is 95%
Alcoholic solution, prepared before use.
2.1, experiment I: the analgesic experiment of mouse.
2.1.1, hot plate method；
Female mice 75 are taken, intelligent hot-plate instrument temperature is adjusted to (55 ± 0.5) DEG C, it is after preheating 10min, female mice is each
1 is merely placed on hot plate, and mouse licks the pain threshold of (s) as the mouse the time required to left back foot from putting to occurring, and screening is qualified
(female mice 75 for licking the sufficient time in 5s to 30s) is only divided into 5 groups by table of random number, every group 15, respectively physiological saline
Group (0.2 mL/10g), aspirin positive controls, granule low dose group, middle dose group and high dose group.Every group of administration
Preceding replication pain threshold, take twice threshold of pain average value as normal pain threshold.After adaptable fed 3 days, by different groups into
Row relative medicine stomach-filling claims time weight 1 time a day every other day, according to weight by being only administered, successive administration 5 days.Divide after the last administration
Not in the pain threshold of 0.5h, 1h, 2h and 3h measurement mouse, if being taken out immediately in mouse 60s without pain reaction, calculated by 60s,
Record improves percentage as a result, calculating each group threshold of pain, as a result carries out t between group with SPSS22 and examines, is to have statistics with P < 0.05
Meaning.
2.1.2, writhing method:
Mouse 75 are taken, half male and half female is divided into 5 groups by table of random number, every group 15, respectively physiological saline group (0.2mL/
10g), aspirin positive controls, granule low dose group, middle dose group, high dose group.After adaptable fed 3 days, by not
Relative medicine stomach-filling is carried out with group, 1 time a day, claims time weight every other day, according to weight by being only administered, successive administration 5 days.In
30min after the last administration, each mouse are injected intraperitoneally 0.6% acetum newly prepared by the dosage of 0.1ml/10g, observe and record
There is the number of writhing response (abdomen shrinks indent, stretches hind leg, and buttocks is raised, crawling) in every mouse in 15min, calculates town
As a result pain percentage carries out t between group with SPSS22 and examines, be statistically significant with P < 0.05.
Analgesia percentage (%)=(saline control group be averaged writhing number-administration group be averaged writhing number)/physiology salt
Water control group is averaged writhing number × 100%.
2.2, experiment II: the anti-inflammatory experiment of mouse.
2.2.1, mouse peritoneal capillary permeability is tested:
Healthy Kunming mouse (18~22 g) 90 is taken, half male and half female is divided into 6 groups, every group 15 by table of random number.Respectively
For normal group (0.2 mL/10 g of physiological saline), model group (0.2 mL/10 g of physiological saline), Yinhuang Particle group, granule
Grain low, middle and high dose groups.After adaptable fed 3 days, relative medicine stomach-filling is carried out by different groups, 1 time a day, is claimed every other day secondary
Weight, according to weight by being only administered, successive administration 10 days.Fasting 12h before last time is administered, after last dose 30min, respectively
The equal 0.5% Evans blue physiological saline 0.1ml/10g (filtering through miillpore filter) of tail vein injection of mouse, gently rubs abdomen, immediately abdominal cavity
Inject 0.8% acetic acid physiological saline 0.2ml/10g(and normally organize and do not inject acetic acid as control), take off after 30min neck put to death it is each small
Mouse splits abdominal cavity, with 5ml normal saline flushing number, collects washing lotion and is settled to 10mL, 3000r/min is centrifuged 20min, takes
Clear liquid measures trap (OD value) with ultraviolet specrophotometer with physiological saline school zero at 590nm, as a result with SPSS22 into
T is examined between row group, is statistically significant with P < 0.05.
In addition, releasing azovan blue concentration according to absorbance A value, method: the log10 dilution of 0.5% azovan blue solution is done
And in colorimetric surveys absorbance A value at 590nm on spectrophotometer, it is known that concentration mensuration point replication 2 times, mean value is as A
Value, seeks the linear dependence between A value and seepage discharge (μ g/mL), finds out the other Evans blue seepage discharge of each group.Administration group suppression
Rate (%) processed=(model group absorbance values-administration group absorbance values)/model group absorbance values × 100%.
2.2.2, carrageenan induced mice pedal swelling is tested:
Mouse 90 are taken, half male and half female is divided into 6 groups by table of random number, every group 15, respectively blank group (physiological saline 0.2
ML/10 g), model group (0.2 mL/10 g of physiological saline), aspirin group, granule low dose group, middle dose group and high agent
Amount group.After adaptable fed 3 days, relative medicine stomach-filling is carried out by different groups, 1 time a day, claims time weight every other day, according to weight
By being only administered, successive administration 10 days.All mouse left hind vola pedis first are surveyed with vernier caliper (precision 0.02mm) after the last administration
Thickness, 1% carrageenan suspension (every 0.02mL) then is subcutaneously injected at left hind vola pedis, it is raw that blank group injects equivalent
Salt water is managed, acute pedal swelling model is caused.30min, 1h, 2h, 3h mouse cause after 1% carrageenan suspension of measurement injection respectively
The thickness of vola pedis after after inflammation, so that the difference of vola pedis thickness and the thickness of the scorching front and back vola pedis of cause is as swelling after inflammation, with swelling
As Testing index, statistical analysis is carried out, investigates the influence of drug Carrageenan induced mice pedal swelling.It is secondary after cause is scorching
Day puts to death mouse, takes the rear vola pedis of mouse or so, is precisely weighed, and left and right vola pedis difference is inflammatory swelling degree, and it is swollen to calculate mouse vola pedis
Swollen inhibiting rate.As a result t between group is carried out with SPSS22 to examine, be statistically significant with P < 0.05.
Following equation is shown in swelling rate and the calculating of pedal swelling inhibiting rate: swelling rate (%)=(thick before thickness-cause is scorching after cause is scorching
Degree)/cause thickness × 100% before inflammation.
2.3, test III: uterine contraction is tested.
2.3.1, uterine activity degree:
Female mice 90 are taken, is randomly divided into 6 groups, every group 15, respectively blank group (physiological saline 0.2mL/10g), model
Group (physiological saline 0.2mL/10g), bolus for woman diseases group, granule granule low dose group, middle dose group and high dose group.Adaptability
After feeding 5 days, relative medicine stomach-filling is carried out by different groups, presses 0.5mg/kg stomach-filling Estradiol Valerate after 6h, 1 time a day, every
It claims time weight, according to weight by being only administered, successive administration 15 days (3~4 periods).Indices are carried out by requirement of experiment
It investigates, t between group is as a result carried out with SPSS22 and is examined, be statistically significant with P < 0.05.
2.3.2, experiment is shunk in uterus automatically:
It plucks after eyeball takes blood and rapidly puts to death mouse, split abdominal cavity, take out uterus and two sides ovary, remove surrounding tissue and rouge
Fat separates side uterus, threads in 1cm on cornua uteri crotch, the free-end of line is connected on tension sensor, uses BL-
Contraction waveform after 420F biological signal collecting and analysis system record uterine contraction are stablized in 10min.Statistics is shunk the frequency, is received
Contracting intensity calculates uterine activity degree (the uterine activity degree=contraction frequency × contraction intensity).As a result t between group is carried out with SPSS22 to examine
It tests, is statistically significant with P < 0.05.
2.4, test IV: β-ep level detects in serum.
After last dose 1h, each group mouse takes blood with plucking eyeball method, after taken blood is stood 1h, centrifugation
(3000r/min, 10min) separates serum, operates according to kit specification.Measure the content of β-ep in mice serum.
β-ep ELISA (ELISA) specific steps are as follows:
1. the sample-adding of standard items: setting standard sample wells and sample well, standard sample wells respectively add the 50 μ L of standard items of various concentration.
2. sample-adding: be respectively set blank well (sample and enzyme marking reagent is not added in blank control wells, remaining each step operation is identical),
Sample to be tested hole.First add 40 μ L of sample diluting liquid in sample to be tested hole on enzyme mark coating plate, then again plus with 10 μ L of sample
(the final dilution of sample is 5 times).Sample is added on ELISA Plate hole bottom by sample-adding, is tried not to touch hole wall, be shaked gently mixed
It is even.
3. enzyme: every hole liquid relief volley of rifle fire adds 100 μ L of enzyme marking reagent, in addition to blank well.
4. incubating: using 37 DEG C of incubation 60min of sealing plate film sealing plate postposition.
5. matching liquid: spare after being diluted with 20 times 20 times of concentrated cleaning solution distilled water.
6. washing: carefully opening sealing plate film, discard liquid, dry, cleaning solution is filled it up in every hole, is discarded after standing 30 seconds, such as
This is repeated 5 times, and pats dry.
7. colour developing: every Kong Xianjia color developing agent A50 μ L, then plus color developing agent B50 μ L, gently concussion mix, 37 DEG C are protected from light colour developing
15min。
8. terminating: every hole adds 50 μ L of terminate liquid, terminates reaction.
9. measurement: being returned to zero with blank well, 450nm wavelength sequentially measures the Absorbance (OD) value in each hole.Measurement should add end
Only carried out in 15min after liquid.
10. calculating: using the concentration of reference substance as abscissa, OD value is abscissa, draws standard curve, obtains linear regression
Equation calculates corresponding concentration according to the OD value of sample, multiplied by extension rate, the as actual concentrations of sample.
3, experimental result and analysis.
3.1, Fig. 1 is in an embodiment of the invention, and granule shows the analgesic activity of hot plate method induced pain mouse
It is intended to.
As shown in Figure 1, granule (2.275,4.55,9.1g/kg) pain threshold improves percentage compared with physiological saline group
Difference is statistically significant (P < 0.01).I.e. granule can improve to some extent hot plate method pain model mouse pain threshold,
Pain reaction number is reduced, analgesic effect has apparent dose-effect relationship, and the analgesic activity of low dose group is worst.(note: with
Physiological saline group compares: P < 0.01 * P < 0.05, * *；Compared with aspirin group: ▲ P < 0.05, ▲ ▲ P < 0.01).
3.2, Fig. 2 is in an embodiment of the invention, and granule shows the analgesic activity of glacial acetic acid induced pain mouse
It is intended to.
As shown in Figure 2, granule (2.275,4.55,9.1g/kg) can reduce the writhing time of acetic acid induced pain mouse significantly
Number, it is statistically significant (P < 0.01) with physiological saline group comparing difference；Granule high dose group, middle dose group can different journeys
Degree ground extends the incubation period of writhing, statistically significant (P < 0.05 or P < 0.01) with physiological saline group comparing difference.From analgesia
Rate sees that analgesic effect has apparent dose-effect relationship.(note: compared with physiological saline group: P < 0.01 * P < 0.05, * *；With Ah
Department's woods group compares: ▲ P < 0.05, ▲ ▲ P < 0.01).
3.3, Fig. 3 to Fig. 4 is schematic diagram in an embodiment of the invention and granule to mice auricle swelling
Influence schematic diagram.Wherein, Fig. 3 is the linear dependence figure between absorbance A value and Evans blue seepage discharge (μ g/mL),
Influence schematic diagram of Fig. 4 granule to mouse capillary permeability.
As shown in Figure 4, granule low, middle and high dose groups can reduce mouse capillary permeability, reduce peritoneal fluid
Exudation, have apparent anti-inflammatory effect, anti-inflammatory effect and model group comparing difference it is statistically significant (P < 0.01).Granule
Middle dose group, high dose group and Yinhuang Particle group comparing difference are not statistically significant (P > 0.05).In terms of inhibiting rate, granule is low
The inhibiting rate of dosage group is worst, but without apparent dose-effect relationship between low middle high dose group.(note: compared with blank group: * P <
0.05, **P<0.01；Compared with Yinhuang Particle group: ▲ P < 0.05, ▲ ▲ P < 0.01；Compared with model group: ▼ P < 0.05, ▼
P < 0.01 ▼).
3.4, Fig. 5 is the schematic diagram of influence of the granule to mouse toes swelling in an embodiment of the invention.
As shown in Figure 5, injection carrageenan causes 30min after inflammation, and granule each group and model group comparing difference are without statistics
It learns meaning (P > 0.05)；1h after cause is scorching, granule high dose group and model group comparing difference are statistically significant (P < 0.05)；It causes
2h and 3h after inflammation, granule low, middle and high dose groups and model group comparing difference it is statistically significant (P < 0.05 or P <
0.01), statistically significant (P < 0.01) with blank group comparing difference, i.e., normal mouse caused by granule Carrageenan is sufficient
Toe swelling has certain inhibiting effect, but effect is unobvious.(note: compared with blank group: P < 0.01 * P < 0.05, * *；With model
Group compares: ▲ P < 0.05, ▲ ▲ P < 0.01).
3.5, Fig. 6 is schematic diagram of the granule to uterus effect of contraction in an embodiment of the invention.
It will be appreciated from fig. 6 that granule each group can reduce the uterine motility enhanced by estrogen, high dose group, middle dose
Amount group, low dose group uterine motility and model group comparing difference are statistically significant (P < 0.05 or P < 0.01), wherein high
Dosage group and blank group comparing difference are not statistically significant, not statistically significant with bolus for woman diseases group comparing difference.(note: with blank
Group compares: P < 0.01 * P < 0.05, * *；Compared with model group: ▲ P < 0.05, ▲ ▲ P < 0.01；Compared with bolus for woman diseases group: ▼ P <
0.05, ▼ P < 0.01 ▼).
3.6, Fig. 7 to Fig. 8 is schematic diagram of the granule to serumβ-ep content in an embodiment of the invention.
As shown in Figure 8, each group can reduce the serumβ-ep content increased extremely by estrogen, high agent to a certain extent
Amount group, middle dose group serumβ-ep and model group comparing difference are statistically significant (P < 0.05 or P < 0.01), wherein high dose
Group is not statistically significant with blank group comparing difference, and each group and bolus for woman diseases group comparing difference are not statistically significant (with blank group ratio
Compared with: P < 0.01 * P < 0.05, * *；Compared with model group: ▲ P < 0.05, ▲ ▲ P < 0.01；Compared with bolus for woman diseases group: P < 0.05 ▼,
P < 0.01 ▼ ▼).
4, brief summary.
The present invention has investigated granule in embodiment 2 and has drawn to mouse corrosion disease analgesia, estrogen enhancing in the effect experiment stage
The uterine motility that rises, estrogen enhancing cause the influence of serumβ-ep level, the results showed that the present invention has centainly anti-inflammatory
Analgesic activity, tool are significantly reduced the uterine motility enhanced by estrogen, can reduce because of estrogen to a certain extent
Extremely serumβ-ep the content increased adjusts endocrine, alleviates menstrual pain.In short, by it is above-mentioned it is various experiment it can be proved that
Chinese medicine and health food of the invention has the healthcare function for alleviating menstrual pain, can enriching yin and nourishing kidney, QI invigorating analgesia, menstruction regulating and pain relieving.
Finally it should be noted that the above content is merely illustrative of the technical solution of the present invention, rather than the present invention is protected
The limitation of range, the simple modification or equivalent replacement that those skilled in the art carry out technical solution of the present invention,
All without departing from the spirit and scope of technical solution of the present invention.
Claims (9)
1. a kind of preparation method for the Chinese medicine and health food for alleviating menstrual period pain, it is characterised in that: the composition alleviation menstrual period pain
The bulk pharmaceutical chemicals of the Chinese medicine and health food of pain mainly have raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae, respectively
The extracting method of bulk pharmaceutical chemicals is water extraction and alcohol precipitation method, and granule or mixture is made in the Chinese medicine and health food for alleviating menstrual period pain；
The preparation method of the granule specifically comprises the following steps:
A, raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae are taken by prescription portion rate, added water to cook 3 times,
Each 2h；
B, said extracted liquid is collected, filtration merges 3 extracting solutions, and filtrate is concentrated into a certain concentration, is cooled to room temperature, and delays
The slow ethyl alcohol that mass percent is added and is 95% simultaneously quickly stirs, and makes alcohol content 80%, and sealing places 12h, is centrifuged to obtain supernatant,
Recycle ethyl alcohol；
C, supernatant is collected, is dried under reduced pressure through 60 DEG C to dry cream, is crushed up to Chinese medical extract；
D, above-mentioned Chinese medical extract is taken, additives are added, is mixed, softwood is made with 80% ethyl alcohol, 10 mesh medicines is crossed and sieves, 60 DEG C of dryings,
Whole grain；
E, it dispenses；
The preparation method of the mixture specifically comprises the following steps:
A, raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae are taken by prescription portion rate, added water to cook 3 times,
Each 2h；
B, said extracted liquid is collected, filtration merges 3 extracting solutions, and filtrate is concentrated into a certain concentration, is cooled to room temperature, and delays
The slow ethyl alcohol that mass percent is added and is 95% simultaneously quickly stirs, and makes alcohol content 80%, and sealing places 12h, is centrifuged to obtain supernatant,
Recycle ethyl alcohol；
C, supernatant is collected, additives are added, constant volume is at certain volume, filtration；
D, packing, sterilizing.
2. a kind of preparation method of Chinese medicine and health food for alleviating menstrual period pain according to claim 1, it is characterised in that:
The parts by weight of each bulk pharmaceutical chemicals in the Chinese medicine and health food for alleviating menstrual period pain are as follows: 1~10 part of raspberry, nutmeg 1~8
Part, 1~8 part of mulberries, 1~8 part of peach kernel, 1~6 part of rhizoma polygonati, 1~6 part of radix polygonati officinalis, 1~6 part of Gorgon fruit and 1~4 part of Radix Glycyrrhizae.
3. a kind of preparation method of Chinese medicine and health food for alleviating menstrual period pain according to claim 2, it is characterised in that:
It is described alleviate menstrual period pain Chinese medicine and health food in each bulk pharmaceutical chemicals parts by weight are as follows: 4~8 parts of raspberry, 3~5 parts of nutmeg,
3~5 parts of mulberries, 3~5 parts of peach kernel, 2~4 parts of rhizoma polygonati, 2~4 parts of radix polygonati officinalis, 2~4 parts of Gorgon fruit and 1~3 part of Radix Glycyrrhizae.
4. a kind of preparation method of Chinese medicine and health food for alleviating menstrual period pain according to claim 3, it is characterised in that:
The parts by weight of each bulk pharmaceutical chemicals in the Chinese medicine and health food for alleviating menstrual period pain are as follows: 6 parts of raspberry, 4 parts of nutmeg, mulberries 4
Part, 4 parts of peach kernel, 3 parts of rhizoma polygonati, 3 parts of radix polygonati officinalis, 3 parts of Gorgon fruit and 2 parts of Radix Glycyrrhizae.
5. a kind of preparation method of Chinese medicine and health food for alleviating menstrual period pain according to claim 1, it is characterised in that:
Decocting amount of water in the step a for the first time is 8~12 times of above-mentioned each bulk pharmaceutical chemicals total weight, after twice amount of water be above-mentioned each
6~10 times of bulk pharmaceutical chemicals total weight.
6. a kind of preparation method of Chinese medicine and health food for alleviating menstrual period pain according to claim 5, it is characterised in that:
Decocting amount of water in the step a for the first time is 10 times of above-mentioned each bulk pharmaceutical chemicals total weight, after twice amount of water be above-mentioned each original
8 times for expecting medicine total weight.
7. a kind of preparation method of Chinese medicine and health food for alleviating menstrual period pain according to claim 1, it is characterised in that:
The additives of addition are the mixtures of preservative or preservative and corrigent.
8. a kind of preparation method of Chinese medicine and health food for alleviating menstrual period pain according to claim 1, it is characterised in that:
Sterilizing methods are boiling sterilization, flowing steam sterilization method or autoclaving.
9. a kind of preparation method of Chinese medicine and health food for alleviating menstrual period pain according to claim 1, it is characterised in that:
Drying time is 3~5h, and the sieve of medicine used in whole grain is 10 meshes and 65 meshes.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757549A (en) * | 2008-11-19 | 2010-06-30 | 唐超 | Traditional Chinese medicine formula for treating dysmenorrhea |
| CN107349411A (en) * | 2017-08-11 | 2017-11-17 | 魏增强 | Chinese medicine composition for treating irregular menstruation and preparation method thereof |
| CN107912773A (en) * | 2017-11-13 | 2018-04-17 | 广禾堂草本生物科技（上海）有限公司 | A kind of preparation for being used to alleviate physical fatigue |
| CN108310347A (en) * | 2018-04-18 | 2018-07-24 | 丹阳市上古本真健康科技有限公司 | A kind of externally applied Chinese medicine and its application method |
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2018
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|---|---|---|---|---|
| CN101757549A (en) * | 2008-11-19 | 2010-06-30 | 唐超 | Traditional Chinese medicine formula for treating dysmenorrhea |
| CN107349411A (en) * | 2017-08-11 | 2017-11-17 | 魏增强 | Chinese medicine composition for treating irregular menstruation and preparation method thereof |
| CN107912773A (en) * | 2017-11-13 | 2018-04-17 | 广禾堂草本生物科技（上海）有限公司 | A kind of preparation for being used to alleviate physical fatigue |
| CN108310347A (en) * | 2018-04-18 | 2018-07-24 | 丹阳市上古本真健康科技有限公司 | A kind of externally applied Chinese medicine and its application method |
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