CN102178774B - Traditional Chinese medicine composition for treating drug-induced renal damage of chicken - Google Patents
Traditional Chinese medicine composition for treating drug-induced renal damage of chicken Download PDFInfo
- Publication number
- CN102178774B CN102178774B CN2011101044342A CN201110104434A CN102178774B CN 102178774 B CN102178774 B CN 102178774B CN 2011101044342 A CN2011101044342 A CN 2011101044342A CN 201110104434 A CN201110104434 A CN 201110104434A CN 102178774 B CN102178774 B CN 102178774B
- Authority
- CN
- China
- Prior art keywords
- parts
- chicken
- chinese medicine
- medicine composition
- kidney
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 94
- 241000287828 Gallus gallus Species 0.000 title claims abstract description 53
- 239000000203 mixture Substances 0.000 title claims abstract description 30
- 230000006378 damage Effects 0.000 title claims abstract description 26
- 229940079593 drug Drugs 0.000 title abstract description 21
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 abstract description 14
- 230000008961 swelling Effects 0.000 abstract description 13
- 208000004880 Polyuria Diseases 0.000 abstract description 11
- 230000035619 diuresis Effects 0.000 abstract description 11
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 210000000952 spleen Anatomy 0.000 abstract description 6
- 230000001939 inductive effect Effects 0.000 abstract description 5
- 241000132012 Atractylodes Species 0.000 abstract 1
- 244000183914 Dianthus superbus Species 0.000 abstract 1
- 235000013535 Dianthus superbus Nutrition 0.000 abstract 1
- 244000111489 Gardenia augusta Species 0.000 abstract 1
- 235000018958 Gardenia augusta Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 241000612166 Lysimachia Species 0.000 abstract 1
- 235000003805 Musa ABB Group Nutrition 0.000 abstract 1
- 240000008790 Musa x paradisiaca Species 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- 235000001188 Peltandra virginica Nutrition 0.000 abstract 1
- 241000972673 Phellodendron amurense Species 0.000 abstract 1
- 235000015266 Plantago major Nutrition 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 238000010926 purge Methods 0.000 abstract 1
- 235000013330 chicken meat Nutrition 0.000 description 48
- 238000012360 testing method Methods 0.000 description 43
- 210000003734 kidney Anatomy 0.000 description 42
- 210000004369 blood Anatomy 0.000 description 13
- 239000008280 blood Substances 0.000 description 13
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 12
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 10
- 229940116269 uric acid Drugs 0.000 description 10
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 9
- 229940098166 bactrim Drugs 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 238000002156 mixing Methods 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 235000008216 herbs Nutrition 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000010298 pulverizing process Methods 0.000 description 6
- 230000000994 depressogenic effect Effects 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000003651 drinking water Substances 0.000 description 5
- 235000020188 drinking water Nutrition 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 208000011580 syndromic disease Diseases 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 241000721047 Danaus plexippus Species 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 201000009442 piebaldism Diseases 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010048469 Kidney enlargement Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 235000014590 basal diet Nutrition 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000003640 drug residue Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 235000013594 poultry meat Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 230000001228 trophic effect Effects 0.000 description 2
- 210000001113 umbilicus Anatomy 0.000 description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 206010061481 Renal injury Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000011157 data evaluation Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- XOSXWYQMOYSSKB-UHFFFAOYSA-M disodium;4-[4-[(4-amino-3-methyl-5-sulfophenyl)-[4-(4-sulfonatophenyl)azaniumylidenecyclohexa-2,5-dien-1-ylidene]methyl]anilino]benzenesulfonate Chemical compound [Na+].[Na+].OS(=O)(=O)C1=C(N)C(C)=CC(C(=C2C=CC(C=C2)=[NH+]C=2C=CC(=CC=2)S([O-])(=O)=O)C=2C=CC(NC=3C=CC(=CC=3)S([O-])(=O)=O)=CC=2)=C1 XOSXWYQMOYSSKB-UHFFFAOYSA-M 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- AQNQGBUEVCAVML-UHFFFAOYSA-N oxazepane Chemical compound C1CCNOCC1 AQNQGBUEVCAVML-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229940126532 prescription medicine Drugs 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000007958 sleep Effects 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 229960005404 sulfamethoxazole Drugs 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention provides a traditional Chinese medicine composition for treating drug-induced renal damage of chicken, comprising the following components in parts by weight: 15-20 parts of fringed pink, 15-20 parts of rhizoma alismatis, 10-15 parts of plantain, 10-15 parts of lysimachia, 5-10 parts of cape jasmine, 5-10 parts of tuckahoe, 5-10 parts of white atractylodes rhizome, 1-5 parts of liquorice and 1-5 parts of phellodendron bark. The traditional Chinese medicine composition has the efficacies of clearing heat and purging fire, inducing diuresis for treating stranguria, promoting the subsidence of swelling, alleviating pain, and replenishing qi to invigorate the spleen, and can be used for treating drug-induced renal damage of chicken with exact curative effect, and the cure rate reaches above 80%.
Description
1, technical field
The invention belongs to Chinese medicine composition, particularly a kind of Chinese medicine composition of treating chicken medicine property renal damage.
2, background technology
In recent years; Fast development along with poultry husbandry; The intensification degree is increasingly high, and various antibacterials of chicken and virosis sickness rate are high, and therefore a large amount of chemical medicine of application prevent and treat in the culture-cycle; Cause the problem of chicken medicine property renal damage more and more serious thus, this has become the major reason that the poultry husbandry benefit glides.It is depressed that the sick chicken of medicine property renal damage shows as spirit, and feather is fluffy and disorderly, bows and seemingly sleeps; Drinking-water increases, row's white or water sample loose stool, egg drop reduction; Cut open the visible renal swelling of inspection, pale, hemorrhage, urate deposition, gently then make chick growth be obstructed, become the chicken fertility performance to reduce, heavy then cause mortality.This sick sickness rate is high, and the clinical diagnosis difficulty is big, is difficult to judge accurate pathogenic factor, and obstinate or end-of-dose failure, and clinical veterinary is at a loss as to what to do.The slowly long even stagnation of chicken all living creatures, expenses for medicine raises, and the price of deed reduces, and causes serious economic loss, and numerous raisers suffer untold misery, and suffer heavy losses.Therefore, strengthen understanding, analyse in depth and find out solution, to effective control primary disease, at utmost retrieve economic losses and have very important meaning this cause of disease.The prescription medicine of the disclosed treatment of prior art chicken medicine property renal damage mainly comprises two big types in Western medicine and Chinese medicine, like SHENZHONG JIEDULING, renal swelling Western medicine such as disappear, Chinese medicines such as subduing swelling and detoxicating is diffusing, kidney oxazepan.This type of Western medicine is cured the symptoms, not the disease, and has safety problems such as drug residue and drug resistance; And existing Chinese medicine preparation maybe be unreasonable on prescription, and perhaps dosage form is unreasonable, influences drug absorption, unsatisfactory curative effect.
3, summary of the invention
The object of the present invention is to provide a kind of determined curative effect, cure rate height, toxic and side effects is little, and drug residue free does not produce chemical sproof Chinese medicine composition of treating chicken medicine property renal damage after the medication.
The Chinese medicine composition of treatment of the present invention chicken medicine property injury of kidney comprises the component of following weight portion: Herba Dianthi 15-20, Rhizoma Alismatis 15-20, Herba Plantaginis 10-15, Herba Lysimachiae 10-15, Fructus Gardeniae 5-10, Poria 5-10, Rhizoma Atractylodis Macrocephalae 5-10, Radix Glycyrrhizae 1-5, Cortex Phellodendri 1-5.
The method for using and the consumption of compositions of the present invention are: after the said composition process of preparing Chinese medicine, oven dry, pulverizing mixing are processed powder, press 0.1～5.0% of complete feed weight and mix the back use.
The method for using and the consumption of compositions of the present invention are: after said composition is processed liquid form, convert water 1～10kg by 1ml～5ml medicinal liquid (the 1ml medicinal liquid is equivalent to the 1g raw medicinal herbs) and supply the chicken crowd freely to drink.
Compositions of the present invention has clearing away heat-fire, inducing diuresis for treating stranguria syndrome, and reducing swelling and alleviating pain, replenishing QI to invigorate the spleen can be used for treating chicken medicine property renal damage.
Prescription is understood: medicament composing prescription of the present invention is theoretical according to Chinese veterinarian, designs in conjunction with the state of an illness characteristic of chicken medicine property renal damage.Main symptom is that disease spirit is depressed during chicken medicine property renal damage, and happiness is slept, row's white or water sample loose stool; Kidney enlargement, pale, hemorrhage, white urate deposition.Confirm clearing away heat-damp and promoting diuresis in view of the above, inducing diuresis for treating stranguria syndrome is the rule of treatment.With Herba Dianthi, Rhizoma Alismatis clearing away heat-fire, the famous medicine of inducing diuresis for treating stranguria syndrome is a monarch drug in the event side.Wherein Herba Dianthi is bitter, cold, falls heart-fire, and sharp small intestinal removes damp and hotly, and the double blood system of walking is invigorated blood circulation with treating stranguria.Attacking of kidney fire let out in Rhizoma Alismatis heat clearing away cold in nature and have the diarrhea of oozing Jiao damp and hot; Promoting diuresis to eliminate damp pathogen, last can making lung-QI pure and descending, with waterway, following can the tonneau part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels and current urine.Semen Plantaginis, Herba Lysimachiae, the Fructus Gardeniae clearing away heat-damp and promoting diuresis is treating stranguria, is ministerial drug altogether, strengthens the efficacy of a drug of monarch drug.Semen Plantaginis goes into kidney, liver, lung meridian, and relieving stranguria by diuresis is not felt frustrated, and the then pure and impure branch of water channel profit is with the effect that protects the liver lung heat clearing; The sweet light profit of Herba Lysimachiae is oozed, and the liver and gall kidney channel is gone in the heat clearing away that is slightly cold, can inducing diuresis for treating stranguria syndrome, and the jaundice eliminating that also can dehumidify, removing toxic substances and promoting subsidence of swelling.It is damp and hot that Fructus Gardeniae is rushed down three warmers clearly, walks edema caused by disorder of QI to remove pathogenic heat, goes into blood system with cooling blood for hemostasis, has clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, the effect of reducing swelling and alleviating pain.Poria, the Rhizoma Atractylodis Macrocephalae are adjuvant drug.The sweet light profit of oozing of Poria wherein, property is flat not inclined to one side, and double tonify deficiency, goes into spleen, kidney, heart channel.Can eliminating dampness and diuresis, again can the spleen invigorating mind calming.The Rhizoma Atractylodis Macrocephalae is sweet, bitter, and temperature is gone into spleen, stomach warp, and the master sets upright with temperature compensation, air making-up and spleen enlivening, and the double water of dispeling is wet.Both assist monarch drug, ministerial drug to dispel the wet effect of water simultaneously as adjuvant, have the effect of tonification, are used for the syndrome of spleen-deficiency that injury of kidney causes.Radix Glycyrrhizae, Cortex Phellodendri are messenger drug.The sweet slow pain relieving of Radix Glycyrrhizae, anti-all medicine bitter colds injure one's stomach, and can the coordinating the actions of various ingredients in a prescription property of medicine.The Cortex Phellodendri master goes into kidney channel, and effect is the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels relatively, but priming power makes drug main will act on kidney and urethra to kidney.
4, the specific embodiment
Below in conjunction with specific embodiment the present invention is further described.
Embodiment 1: the Chinese medicine composition of treatment chicken medicine property renal damage, prescription is formed by weight being expressed as: Herba Dianthi 15, Rhizoma Alismatis 15, Herba Plantaginis 10, Herba Lysimachiae 10, Fructus Gardeniae 5, Poria 5, the Rhizoma Atractylodis Macrocephalae 5, Radix Glycyrrhizae 1, Cortex Phellodendri 1.Raw material is selected, through concocting, oven dry, pulverizing the back mixing or (the 1ml medicinal liquid is equivalent to the 1g raw medicinal herbs) can make present embodiment after extraction medicine.
Embodiment 2: the Chinese medicine composition of treatment chicken medicine property renal damage, prescription is formed by weight being expressed as: Herba Dianthi 20, Rhizoma Alismatis 20, Herba Plantaginis 15, Herba Lysimachiae 15, Fructus Gardeniae 10, Poria 10, the Rhizoma Atractylodis Macrocephalae 10, Radix Glycyrrhizae 5, Cortex Phellodendri 5.Raw material is selected, through concocting, oven dry, pulverizing the back mixing or (the 1m1 medicinal liquid is equivalent to the 1g raw medicinal herbs) can make present embodiment after extraction medicine.
Embodiment 3: the Chinese medicine composition of treatment chicken medicine property renal damage, prescription is formed by weight being expressed as: Herba Dianthi 16, Rhizoma Alismatis 17, Herba Plantaginis 12, Herba Lysimachiae 13, Fructus Gardeniae 7, Poria 7, the Rhizoma Atractylodis Macrocephalae 7, Radix Glycyrrhizae 2, Cortex Phellodendri 2.Raw material is selected, through concocting, oven dry, pulverizing the back mixing or (the 1ml medicinal liquid is equivalent to the 1g raw medicinal herbs) can make present embodiment after extraction medicine.
Embodiment 4: the Chinese medicine composition of treatment chicken medicine property renal damage, prescription is formed by weight being expressed as: Herba Dianthi 18, Rhizoma Alismatis 18, Herba Plantaginis 14, Herba Lysimachiae 14, Fructus Gardeniae 8, Poria 8, the Rhizoma Atractylodis Macrocephalae 8, Radix Glycyrrhizae 4, Cortex Phellodendri 4.Raw material is selected, through concocting, oven dry, pulverizing the back mixing or (the 1ml medicinal liquid is equivalent to the 1g raw medicinal herbs) can make present embodiment after extraction medicine.
Embodiment 5: treatment chicken medicine property injury of kidney Chinese medicine composition, prescription is formed by weight being expressed as: Herba Dianthi 17, Rhizoma Alismatis 16, Herba Plantaginis 13, Herba Lysimachiae 12, Fructus Gardeniae 6, Poria 9, the Rhizoma Atractylodis Macrocephalae 6, Radix Glycyrrhizae 3, Cortex Phellodendri 3.Raw material is selected, through concocting, oven dry, pulverizing the back mixing or (the 1ml medicinal liquid is equivalent to the 1g raw medicinal herbs) can make present embodiment after extraction medicine.
Traditional Chinese medicine composition for treating chicken medicine property renal damage test report
1 materials and methods
1.1 medicine
Test sample: by embodiment 1-5 (1ml is equivalent to the 1g crude drug) is provided, is followed successively by test sample 1-5.Subduing swelling and detoxicating looses (the 3rd of veterinary drug provincial standard rising national standard), Tianjin Tianheli Pharmaceutical R & D Co., Ltd., lot number: 0904017.Fu side's Sulfamethoxazole (bactrim), the smart rich Bioisystech Co., Ltd in Guangzhou produces lot number: 0801022.
1.2 experimental animal
Blue brown laying hen 2000 plumages in 70 ages in days sea are available from source, waterside, Baoding fowl industry Co., Ltd.Wherein 1800 are used for bactrim modeling test; All the other 200 as blank, and do not feed bactrim and other any medicines only give conventional feeding and management.
1.3 key instrument
Electronic balance, refrigerator, electronics biochemical instruments, optical microscope etc.
1.4 modeling test
Get bactrim using dosage and method that 1800 chickens are confirmed according to the modeling dosetest, carry out the modeling test.Bactrim is pressed the 2.0g/kg feed mixing and is added, and when using to the 7th day continuously, full crowd chicken shows as: spirit is depressed, feed intake descends.1800 chickens of full crowd amount to dead 50 by the 7th day 24:00, and dead the dissection with the extremely depressed chicken of spirit found: kidney enlargement, pale; Part is piebaldism kidney appearance; The kidney sections observation is found: renal cells is downright bad, and tube wall thickens, and downright bad cell blocks the renal tubules chamber.
Reject spirit extremely depressed part chicken and dead chicken, divide 7 groups, be used for follow-up test 1400 chickens.
1.5 test is divided into groups and is handled
1400 chickens of bactrim modeling success are divided into 7 processed group (comprising II, III, IV, V, VI, VII, VIII group) at random, establish 4 repetitions for every group, each repeats 50 chickens.The II group is the medicine matched group, and spice adds the diffusing 3g/kg feedstuff of subduing swelling and detoxicating in the daily ration; III, IV, V, VI, VII are followed successively by test sample 1,2, and 3,4,5 adopt the drinking-water administration, and whole day is concentrated at twice and drunk; VIII organizes negative matched group, does not add medicine.The modeling success is (promptly testing the 13rd) beginning administration after 5 days, continuous use 5 days.In addition, the I group is the blank group, 200 chickens, do not feed bactrim and other any medicines.Test is divided into groups like table 1.49 days experimental periods.
Table 1 test packet transaction table
1.6 feeding and management
The test chicken all adopts bilayer to raise in cages, free choice feeding and drinking-water, and 49 days experimental periods,, hen house keeps hygienically clean, the well-ventilated.
According to the large-scale feeding standard preparation of China blue brown laying hen in sea, daily ration is once got all the ready, and the sampling bottling is to be measured.Basal diet is formed and trophic level, sees table 2.
Table 2 basal diet is formed and trophic level
Annotate: compound additive contains multivitamin, trace element and methionine, lysine etc., and the daily ration design meets NRC (1994) standard.
1.7 detect index and method
1.7.1 the mensuration of renal function index blood uric acid
From every group, got venous blood collection under 30 chicken wing on the 12nd, 21,35,49 day respectively at test, the separation of serum sample uses the electronics biochemical instruments to measure blood uric acid content.
1.7.2 kidney organ's index
Above-mentioned chicken is taken out kidney, observe and after the naked eyes of record nephridial tissue change, reject fat, weigh and calculate the kidney index.The exponential computational methods of kidney are following:
Kidney index=kidney net weight (g)/body weight (kg)
1.8 curative effect overall merit
Come overall merit Chinese medicine composition curative effect with mortality rate and cure rate.
Mortality rate=(dead chicken number/test chicken number of elements) * 100%; Cure rate=(curing chicken number/test chicken number of elements) * 100%
Cure: test chicken spirit is normal, and watery stool, Calx just disappear, and it is normal that appetite is recovered; Analyse kidney swelling complete obiteration, color is cerise; Lab testing uric acid content and kidney index return to normally (with blank group mean urinary acid content and kidney index is standard, is not higher than this standard and is normally).
2 results
2.1 Chinese medicine composition is to the influence of the average blood uric acid of the blue brown laying hen in sea
Chinese medicine composition is seen table 3 to the result that influences of the average blood uric acid of laying hen.After laying hen goes into house, before beginning drinking-water and feeding, carry out the wing venous blood collection on an empty stomach, measure the content of blood uric acid, laying hen beginning close in value between each group of result, difference is not remarkable, has comparability.When testing 21 and 35; The blood uric acid content difference of test sample group and medicine matched group test chicken is not obvious; But compare with the blank group and to have significant difference (P≤0.05); After comparing (P≤0.05) test chicken that also has significant difference with negative control group and giving test sample and treat with control drug, kidney damage takes a turn for the better to some extent.
When testing 49, the test sample group is compared with the medicine matched group, and its serum uric acid level is lower than the medicine matched group, compares no significant difference (P≤0.05) with the blank group.This presentation of results, test sample give the sick chicken therapeutic effect of injury of kidney and are superior to control drug.
The average blood uric acid content of laying hen is respectively organized in table 3 test
Annotate: same perpendicular row contains the alphabetical expression difference of identical shoulder motes not remarkable (P＞0.05), different letter representation significant differences (P≤0.05) in the table.
2.2 Chinese medicine composition is to the influence of the blue brown laying hen kidney in sea
Chinese medicine composition is seen table 4 to the result that influences of the blue brown laying hen kidney in sea.After laying hen goes into house, before beginning drinking-water and feeding, weigh on an empty stomach, the laying hen body weight is close between each group, and difference is not remarkable.Tested the 12nd day, kidney index and the blank group of II, III, IV, V, VI, VII, VIII group laying hen relatively have significant difference (P≤0.05), and watery stool occurs; The depressed state of appearance that waits of spirit; The piebaldism kidney also appears in the kidney surface, and the edema situation is explained the modeling success.
When testing 21 and 35, the kidney index differential of III, IV, V, VI, VII test sample group and medicine matched group is not obvious, has significant difference but compare with the blank group, compares significant difference (P≤0.05) with negative control group; The chicken crowd's of test sample group and medicine matched group watery stool and mental condition take a favorable turn, and the piebaldism kidney of kidney outward appearance and edema situation are also being alleviated.
When testing 49, the test sample group is compared with the medicine matched group, and its kidney index is a little less than the medicine matched group; 5 groups of test sample test chicken crowd kidney swelling complete obiterations, color is cerise, and shows very nearly the samely with the chicken crowd of blank group, but the control drug group has minority chicken crowd still to show morbid state.This result of the test explanation, test sample are used to treat the back effect of chicken medicine property injury of kidney and are superior to the control drug group, can make the disease chicken kidney return to normal level.
Table 4 Chinese medicine composition is to the exponential influence of the blue brown laying hen kidney in sea
Annotate: same perpendicular row contains the alphabetical expression difference of identical shoulder motes not remarkable (P＞0.05), different letter representation significant differences (P≤0.05) in the table.
2.3 curative effect Comprehensive Assessment result
This test is made medicine property renal injury model with bactrim; Utilize Chinese medicine composition of the present invention to treat, and contrast treatment, test after 49 days with diffusing work of subduing swelling and detoxicating; The tracking and measuring uric acid content, and the aggregation of data that the morphology outward appearance of the blue brown chicken kidney in kidney exponential sum sea is observed is evaluated.Evaluation result is seen table 5.
The aggregation of data evaluation result of the brown laying hen of table 5 the 49th Ri Hailan (50 of sums)
| Group | Cure number (only) | Death toll (only) | Cure rate (%) | Mortality rate (%) |
| The blank group | 0 | 0 | ||
| The medicine matched group | 35 | 5 | 70.00 | 10.00 |
| Test sample 1 | 41 | 3 | 82.00 | 6.00 |
| Test sample 2 | 39 | 5 | 78.00 | 10.00 |
| Test sample 3 | 42 | 4 | 84.00 | 8.00 |
| Test sample 4 | 41 | 4 | 82.00 | 8.00 |
| Test sample 5 | 44 | 3 | 88.00 | 6.00 |
| Negative control group | 40 | 80.00 |
Above result shows that embodiment of the invention 1-5 medicine is 82.80% to the sea average cure rate of blue brown laying hen medicine property injury of kidney, is higher than 12.8 percentage points of the diffusing groups of subduing swelling and detoxicating.
3 conclusions
Chinese medicine composition provided by the invention can be used for the damage of curative rerum natura Testis et penis Gallus domesticus, its determined curative effect, and cure rate is high, has clinical value.
Claims (1)
1. Chinese medicine composition of treating chicken medicine property renal damage; It is characterized in that the raw material of said Chinese medicine composition is made up of the component of following weight portion: Herba Dianthi 15-20, Rhizoma Alismatis 15-20, Herba Plantaginis 10-15, Herba Lysimachiae 10-15, Fructus Gardeniae 5-10, Poria 5-10, Rhizoma Atractylodis Macrocephalae 5-10, Radix Glycyrrhizae 1-5, Cortex Phellodendri 1-5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101044342A CN102178774B (en) | 2011-04-26 | 2011-04-26 | Traditional Chinese medicine composition for treating drug-induced renal damage of chicken |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101044342A CN102178774B (en) | 2011-04-26 | 2011-04-26 | Traditional Chinese medicine composition for treating drug-induced renal damage of chicken |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102178774A CN102178774A (en) | 2011-09-14 |
| CN102178774B true CN102178774B (en) | 2012-07-04 |
Family
ID=44565180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101044342A Expired - Fee Related CN102178774B (en) | 2011-04-26 | 2011-04-26 | Traditional Chinese medicine composition for treating drug-induced renal damage of chicken |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102178774B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103463470B (en) * | 2013-08-10 | 2016-03-02 | 安徽快康生物科技有限公司 | A kind of chicken Chinese medicine composition protecting the liver logical kidney |
| CN106310031A (en) * | 2015-06-24 | 2017-01-11 | 陆雪 | Drug for treating chicken gout |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899531A (en) * | 2006-07-05 | 2007-01-24 | 河北农业大学 | Medicine for preventing and treating chicken kidney swelling disease |
-
2011
- 2011-04-26 CN CN2011101044342A patent/CN102178774B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899531A (en) * | 2006-07-05 | 2007-01-24 | 河北农业大学 | Medicine for preventing and treating chicken kidney swelling disease |
Non-Patent Citations (2)
| Title |
|---|
| 舒刚.鸡尿酸盐代谢障碍的发生及其中西医防治.《山东家禽》.2003,(第5期),28-31. * |
| 马爱团.鸡肾病的中兽医辨证与治疗.《北方牧业》.2011,25. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102178774A (en) | 2011-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108210866A (en) | Composition with invigorating the spleen to clear away damp pathogen effect and preparation method thereof | |
| CN102688420B (en) | Traditional Chinese medicine decoction for treating psoriasis | |
| CN101579119A (en) | Nutritional food with function of relaxing bowel and preparation method thereof | |
| CN103007208B (en) | Traditional Chinese medicine formula for preventing fatty liver hemorrhagic syndrome of broiler chickens | |
| CN105663546A (en) | Chinese traditional medicine composition for treating proventriculitis of chicken | |
| CN104472789A (en) | Fructus sophorae tea for loosening bowels to relieve constipation and preparation method of fructus sophorae tea | |
| CN102178774B (en) | Traditional Chinese medicine composition for treating drug-induced renal damage of chicken | |
| CN104138526A (en) | Granules prepared by combined spicebush roots, dendrobium candidum and ginseng | |
| CN103705796B (en) | A kind of pharmaceutical composition for the treatment of diarrhoea and preparation method thereof | |
| CN101843891B (en) | Blood tonifying composition | |
| CN103735832B (en) | Medicine being used for the treatment of Chicken salpingitis and preparation method thereof | |
| CN104338051A (en) | Traditional Chinese medicine composition for treating child virus diarrhea | |
| CN106234803A (en) | For treating the feedstuff of piglet pujos blancos | |
| CN104474112A (en) | Traditional Chinese medicine for treating urinary calculus and preparation method of traditional Chinese medicine | |
| CN104524167A (en) | Traditional Chinese medicine preparation for treating liver cirrhosis and liver ascites and preparation method of traditional Chinese medicine preparation | |
| CN102258715A (en) | Honeysuckle wine | |
| CN103705835B (en) | Medicine being used for the treatment of cad pig and preparation method thereof | |
| CN103181559A (en) | Nutritious food with bowel nourishing and purgation functions and preparation method thereof | |
| CN102755568B (en) | Health-care product for assisting in decreasing blood sugar and preparation method thereof | |
| CN104623068A (en) | Medicine for treating infantile fever and convulsion and preparation method of medicine | |
| CN104800625B (en) | A kind of Chinese medicine preparation and preparation method thereof improving poultry class production performance | |
| CN103463248B (en) | One boar growth promotion Chinese medicine oral liquid | |
| CN103719661A (en) | Oral liquid health product with function of replenishing blood | |
| CN101966268A (en) | Traditional Chinese medicinal preparation for improving pig cutability | |
| CN104189459A (en) | Traditional Chinese medicine preparation for treating constipation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: BAODING JIZHONG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: BEIJING JIUCAOTANG PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. Effective date: 20150721 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20150721 Address after: 071500 industrial city, Gaoyang County, Hebei, Baoding Patentee after: BAODING JIZHONG PHARMACEUTICAL Co.,Ltd. Address before: 100085, Beijing, Haidian District on the road No. 26, Zhongguancun venture building, room 1012 Patentee before: BEIJING JIUCAOTANG PHARMACEUTICAL RESEARCH INSTITUTE Co.,Ltd. |
|
| DD01 | Delivery of document by public notice |
Addressee: Lei Siqi Document name: Notification of Passing Examination on Formalities |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120704 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |