CN102178616B - Hyaluronic acid micro-needle adhesive film and preparation method thereof - Google Patents
Hyaluronic acid micro-needle adhesive film and preparation method thereof Download PDFInfo
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- CN102178616B CN102178616B CN 201110117237 CN201110117237A CN102178616B CN 102178616 B CN102178616 B CN 102178616B CN 201110117237 CN201110117237 CN 201110117237 CN 201110117237 A CN201110117237 A CN 201110117237A CN 102178616 B CN102178616 B CN 102178616B
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- hyaluronic acid
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- needle adhesive
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 53
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 53
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 53
- 239000002313 adhesive film Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000004480 active ingredient Substances 0.000 claims abstract description 10
- 102000008186 Collagen Human genes 0.000 claims abstract description 6
- 108010035532 Collagen Proteins 0.000 claims abstract description 6
- 239000008367 deionised water Substances 0.000 claims abstract description 6
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 6
- 230000000694 effects Effects 0.000 claims description 13
- 238000005538 encapsulation Methods 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 11
- 238000003825 pressing Methods 0.000 claims description 11
- 238000007791 dehumidification Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 239000004615 ingredient Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 150000005846 sugar alcohols Polymers 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 230000002421 anti-septic effect Effects 0.000 claims description 6
- 238000013019 agitation Methods 0.000 claims description 5
- 238000004945 emulsification Methods 0.000 claims description 5
- 238000010792 warming Methods 0.000 claims description 5
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 4
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 claims description 2
- 229960000271 arbutin Drugs 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 claims description 2
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims description 2
- 230000018044 dehydration Effects 0.000 abstract 3
- 238000006297 dehydration reaction Methods 0.000 abstract 3
- 230000006835 compression Effects 0.000 abstract 2
- 238000007906 compression Methods 0.000 abstract 2
- 229920001436 collagen Polymers 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003077 polyols Chemical class 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- 239000011888 foil Substances 0.000 description 3
- 230000005714 functional activity Effects 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- 206010006242 Breast enlargement Diseases 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 108010001394 Disaccharidases Proteins 0.000 description 1
- PVQLIDFBJHGSQD-JJKGCWMISA-N NC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[S] Chemical group NC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[S] PVQLIDFBJHGSQD-JJKGCWMISA-N 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 210000000695 crystalline len Anatomy 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Images
Abstract
The invention discloses a hyaluronic acid micro-needle adhesive film and a preparation method thereof. The hyaluronic acid micro-needle adhesive film comprises the following functional active ingredients in percentage by weight: hyaluronic acid, collagen, polyol, an active ingredient, preservative and deionized water. The preparation method comprises: placing the components into a vacuum emulsion pot in a ratio, heating to 40 to 70 DEG C with stirring for uniform dissolution, vacuumizing and defoaming to obtain primary pulp; pouring the primary pulp into a mold, placing the mold in constant-temperature dehumidifying equipment at 40 to 80 DEG C for dehydration for 3 to 8 hours, and when the water content is detected to be 5 to 20 percent, performing the compression forming with the adhesive film to form micro needles on the active components; after the compression forming, continuing to perform dehydration in the constant-temperature dehumidifying equipment, and accomplishing dehydration when the water content is detected to be 0.1 to 5 percent; and when the temperature is 15 to 25 DEG C, encapsulating a film in a closed space with a humidity of 20 to 40 percent.
Description
Technical field
The present invention relates to a kind of hyaluronic acid micro-needle adhesive film, the invention still further relates to a kind of method for preparing this hyaluronic acid micro-needle adhesive film.
Background technology
Hyaluronic acid, formal name used at school are hyaluronic acid (Hyaluronic acid is called for short HA) or claim hyaluronic acid, by the straight chain polymer polysaccharide that disaccharidase unit's (glucuronic acid-N-second sulfur aminoglucose) forms, be the material that naturally exists in a kind of tissue.Occurring in nature is present in the folder film of the crystalline lens of vertebrate connective tissue, mucous tissue, eyeball and some antibacterial widely, having played the part of the key player of substrate in the skin corium of human skin, is that transporting between maintenance whole on organizational structure or cell all has very important function.
Hyaluronic acid not only has the skin elasticity of maintenance function, can also pin large quantity of moisture, tissue had the moisturizing lubrication, make the full youth of skin flexible, but in case along with the growth at aging and age, hyaluronic acid loss speed is during than fast growth, the skin shortage moisture that also will gradually become, the elasticity that tarnishes, the catabiosis such as wrinkle just occur of getting off for a long time.
Along with the development of science and technology, hyaluronic acid just can not use by injection fillers at present, has developed the external hyaluronic acid.Contain the beauty treatment compositions such as hyaluronic acid, SOD, cell growth factor granule in this external hyaluronic acid.The use crowd has no longer only just hoped the crowd of reduce wrinkle breast enlargement, and the external hyaluronic acid uses that the crowd can be that skin is dark yellow, coarse, matt, wrinkle, contain some personages that like to be beautiful such as mottle on the face.Must, although the external hyaluronic acid has lost the beauty functions of traditional filled type hyaluronic acid breast enlargement, be suitable for more crowds
The mask product of using hyaluronic acid production on the existing market is a lot, but it fills a prescription complicated, and DeGrain, and can only rest on skin surface all existing aspect the performance of function effect, more difficultly allow effective component enter to have given play to better effect in skin, so existing hyaluronic acid pad pasting needs further to improve.
Summary of the invention
The objective of the invention is provides a kind of good effect in order to overcome weak point of the prior art, can transdermal the hyaluronic acid micro-needle adhesive film on top layer.
Another object of the present invention is to provide a kind of method for preparing above-mentioned hyaluronic acid micro-needle adhesive film.
In order to achieve the above object, the present invention adopts following scheme:
A kind of hyaluronic acid micro-needle adhesive film, percentage composition is composed of the following components by weight to it is characterized in that the function functional component of this hyaluronic acid micro-needle adhesive film:
A kind of hyaluronic acid micro-needle adhesive film as above is characterized in that described polyhydric alcohol is glycerol or butanediol.
A kind of hyaluronic acid micro-needle adhesive film as above is characterized in that described effect active ingredient is arbutin or NAP.
A kind of hyaluronic acid micro-needle adhesive film as above is characterized in that described antiseptic is BIT or Methylisothiazolinone.
The present invention prepares the method for hyaluronic acid micro-needle adhesive film as above, it is characterized in that comprising the following steps:
A, in proportion with hyaluronic acid, collagen protein, polyhydric alcohol, the effect active ingredient, antiseptic and deionized water are put into vacuum emulsification pot, under agitation, be warming up to 40-70 ℃ and be uniformly dissolved, and vacuumizing and defoaming is processed to get virgin pulp liquid;
B, above-mentioned virgin pulp liquid is put into mould, then the constant temperature dehumidification equipment of mould being put into 40-80 ℃ carries out processed, 3-8 hour, detect the pressing and forming that carries out that carries out when water content is 5-20% with pad pasting, form miniature needle-like on described function ingredients;
C, pressing are shaped and follow-up continuing carry out processed in constant temperature dehumidification equipment, detect water content and complete processed when 0.1-5%;
D, be 15-25 ℃ in temperature, humidity is to carry out the encapsulation of diaphragm in the confined space of 20-40%, gets final product.
1, preparation method according to claim 5 is characterized in that using fixedly needle adhesive film of hard carriage in the encapsulation process described in step D, to avoid for distortion.
In sum, beneficial effect of the present invention:
The present invention has the advantages that to make film coating process uniqueness and component proportion excellence, in hyaluronic acid pad pasting surface formation microneedle configuration, allow during the hyaluronic acid micro-needle that contains the functional activity composition thrusts skin at skin by application film, and dissolve under the effect of moisture content, hyaluronic acid and functional activity composition are played a role in skin.Adopt the micropin cylinder of frame for movement on the relative market of product of the present invention, hardly can tingle, can not damage and cause skin infection skin, but have adopt micropin cylinder mode with good effects; On another market relatively, existing pad pasting series products can only be on the keratodermatitis top layer, allow the mode that active ingredient plays a role that the advantage that remarkable result is directly arranged is arranged by infiltrating or permeating, common pad pasting product efficacy composition enters substantially less than playing a role in skin in the market.
Description of drawings
Fig. 1 is the schematic diagram of mould of the present invention.
The specific embodiment
Below in conjunction with the specific embodiment, the present invention is described further:
Embodiment 1
The function functional component of 100kg hyaluronic acid micro-needle adhesive film of the present invention, composed of the following components:
Preparing hyaluronic acid micro-needle adhesive film of the present invention comprises the following steps:
E, with above-mentioned hyaluronic acid, collagen protein, polyhydric alcohol, the effect active ingredient, BIT and deionized water are put into vacuum emulsification pot, under agitation, be warming up to 40-70 ℃ and be uniformly dissolved, and vacuumizing and defoaming is processed to get virgin pulp liquid;
F, above-mentioned virgin pulp liquid is put into mould, then the constant temperature dehumidification equipment of mould being put into 40-80 ℃ carries out processed, 3-8 hour, detect the pressing and forming that carries out that carries out when water content is 5-20% with pad pasting, form miniature needle-like on described function ingredients;
G, pressing are shaped and follow-up continuing carry out processed in constant temperature dehumidification equipment, detect water content and complete processed when 0.1-5%;
H, be 15-25 ℃ in temperature, humidity is to carry out the encapsulation of diaphragm in the confined space of 20-40%, uses fixedly needle adhesive film of hard carriage in described encapsulation process, to avoid for distortion;
I, needle adhesive film pack with aluminum foil bag, detect each package encapsulation to guarantee that moisture content can not enter in packing, cause hyaluronic acid micro-needle to paste the suction dissolving.
Embodiment 2
The function functional component of 100kg hyaluronic acid micro-needle adhesive film of the present invention, composed of the following components:
Preparing hyaluronic acid micro-needle adhesive film of the present invention comprises the following steps:
A, with above-mentioned hyaluronic acid, collagen protein, polyhydric alcohol, the effect active ingredient, antiseptic and deionized water are put into vacuum emulsification pot, under agitation, be warming up to 40-70 ℃ and be uniformly dissolved, and vacuumizing and defoaming is processed to get virgin pulp liquid;
B, above-mentioned virgin pulp liquid is put into mould, then the constant temperature dehumidification equipment of mould being put into 40-80 ℃ carries out processed, 3-8 hour, detect the pressing and forming that carries out that carries out when water content is 5-20% with pad pasting, form miniature needle-like on described function ingredients;
C, pressing are shaped and follow-up continuing carry out processed in constant temperature dehumidification equipment, detect water content and complete processed when 0.1-5%;
D, be 15-25 ℃ in temperature, humidity is to carry out the encapsulation of diaphragm in the confined space of 20-40%, uses fixedly needle adhesive film of hard carriage in described encapsulation process, to avoid for distortion;
E, needle adhesive film pack with aluminum foil bag, detect each package encapsulation to guarantee that moisture content can not enter in packing, cause hyaluronic acid micro-needle to paste the suction dissolving.
Embodiment 3
The function functional component of 100kg hyaluronic acid micro-needle adhesive film of the present invention, composed of the following components:
Preparing hyaluronic acid micro-needle adhesive film of the present invention comprises the following steps:
A, with above-mentioned hyaluronic acid, collagen protein, polyhydric alcohol, the effect active ingredient, antiseptic and deionized water are put into vacuum emulsification pot, under agitation, be warming up to 40-70 ℃ and be uniformly dissolved, and vacuumizing and defoaming is processed to get virgin pulp liquid;
B, above-mentioned virgin pulp liquid is put into mould, then the constant temperature dehumidification equipment of mould being put into 40-80 ℃ carries out processed, 3-8 hour, detect the pressing and forming that carries out that carries out when water content is 5-20% with pad pasting, form miniature needle-like on described function ingredients;
C, pressing are shaped and follow-up continuing carry out processed in constant temperature dehumidification equipment, detect water content and complete processed when 0.1-5%;
D, be 15-25 ℃ in temperature, humidity is to carry out the encapsulation of diaphragm in the confined space of 20-40%, uses fixedly needle adhesive film of hard carriage in described encapsulation process, to avoid for distortion;
E, needle adhesive film pack with aluminum foil bag, detect each package encapsulation to guarantee that moisture content can not enter in packing, cause hyaluronic acid micro-needle to paste the suction dissolving.
Wherein in embodiment 1-3 the structure of mould as described in Figure 1, virgin pulp liquid is put into after the mould pressing and forming described function ingredients and is simultaneously gone up and can form miniature needle-like.Described function ingredients thrusts in skin by described miniature acicular texture, and dissolves under the effect of moisture content, and hyaluronic acid and functional activity composition are played a role in skin.
Claims (5)
1. the preparation method of a hyaluronic acid micro-needle adhesive film is characterized in that comprising the following steps:
A, with the 0.5-5% hyaluronic acid, 0.1-1% collagen protein, 1-15% polyhydric alcohol, 0.5-10% effect active ingredient, 0.1-2% antiseptic and 67-95% deionized water are put into vacuum emulsification pot, under agitation, be warming up to 40-70 ℃ and be uniformly dissolved, and vacuumizing and defoaming is processed to get virgin pulp liquid;
B, above-mentioned virgin pulp liquid is put into mould, then the constant temperature dehumidification equipment of mould being put into 40-80 ℃ carries out processed, 3-8 hour, detect the pressing and forming that carries out that carries out when water content is 5-20% with pad pasting, form miniature needle-like on described function ingredients;
C, pressing are shaped and follow-up continuing carry out processed in constant temperature dehumidification equipment, detect water content and complete processed when 0.1-5%;
D, be 15-25 ℃ in temperature, humidity is to carry out the encapsulation of diaphragm in the confined space of 20-40%, gets final product;
Percentage composition in above-mentioned steps is weight percentage.
2. the preparation method of a kind of hyaluronic acid micro-needle adhesive film according to claim 1, is characterized in that described polyhydric alcohol is glycerol or butanediol.
3. the preparation method of a kind of hyaluronic acid micro-needle adhesive film according to claim 1, is characterized in that described effect active ingredient is arbutin or NAP.
4. the preparation method of a kind of hyaluronic acid micro-needle adhesive film according to claim 1, is characterized in that described antiseptic is BIT or Methylisothiazolinone.
5. the preparation method of a kind of hyaluronic acid micro-needle adhesive film according to claim 1, is characterized in that using fixedly needle adhesive film of hard carriage in the encapsulation process described in step D, to avoid for distortion.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110117237 CN102178616B (en) | 2011-05-06 | 2011-05-06 | Hyaluronic acid micro-needle adhesive film and preparation method thereof |
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| CN 201110117237 CN102178616B (en) | 2011-05-06 | 2011-05-06 | Hyaluronic acid micro-needle adhesive film and preparation method thereof |
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| CN102178616B true CN102178616B (en) | 2013-06-05 |
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| CN104902963B (en) * | 2012-07-06 | 2018-03-20 | 通用医疗公司 | The method and apparatus of dermatological treatment |
| EP2958533B8 (en) | 2013-02-20 | 2022-02-16 | Cytrellis Biosystems, Inc. | Methods and devices for skin tightening |
| EP2962680A4 (en) * | 2013-02-28 | 2016-12-28 | Amorepacific Corp | Composition for maintaining efficacy of filler |
| CN104095761A (en) * | 2013-04-08 | 2014-10-15 | 上海汇林医药科技有限公司 | Polymer microneedle patch and application thereof |
| WO2015095675A1 (en) | 2013-12-19 | 2015-06-25 | Cytrellis Biosystems, Inc. | Methods and devices for manipulating subdermal fat |
| CN103893018B (en) * | 2014-04-16 | 2016-02-03 | 华熙福瑞达生物医药有限公司 | A kind of soluble transparent matter acid microneedle patch |
| US11324534B2 (en) | 2014-11-14 | 2022-05-10 | Cytrellis Biosystems, Inc. | Devices and methods for ablation of the skin |
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| JP6369992B2 (en) * | 2015-03-19 | 2018-08-08 | ライオン株式会社 | Dissolving microneedle formulation |
| CN105434332A (en) * | 2015-12-02 | 2016-03-30 | 江汉大学 | Preparation method for water-soluble biological macromolecular microneedle membrane |
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| CN107638306A (en) * | 2016-07-21 | 2018-01-30 | 卢乃宏 | Skin care products effective ingredient method for concentration |
| US11464954B2 (en) | 2016-09-21 | 2022-10-11 | Cytrellis Biosystems, Inc. | Devices and methods for cosmetic skin resurfacing |
| CN107375008B (en) * | 2017-07-19 | 2020-07-10 | 广州新济药业科技有限公司 | Soluble microneedle patch for whitening and preparation method thereof |
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| CN108158843A (en) * | 2017-12-25 | 2018-06-15 | 陕西佰傲再生医学有限公司 | It is a kind of can the sodium hyaluronate stoste and preparation method thereof that imports of micropin |
| CN108355238A (en) * | 2018-04-04 | 2018-08-03 | 陈彦彪 | A kind of nutrition line style micropin |
| CN110037938A (en) * | 2019-03-06 | 2019-07-23 | 胡婧 | A kind of hyaluronic acid micro-needle patch and preparation method thereof |
| CN113520905A (en) * | 2021-03-25 | 2021-10-22 | 甘肃天际生物科技有限公司 | Instant collagen microneedle and preparation method thereof |
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