CN104644456A - Percutaneous absorption soluble preparation paster, preparation method thereof and tool used in preparation method - Google Patents
Percutaneous absorption soluble preparation paster, preparation method thereof and tool used in preparation method Download PDFInfo
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- CN104644456A CN104644456A CN201510023584.9A CN201510023584A CN104644456A CN 104644456 A CN104644456 A CN 104644456A CN 201510023584 A CN201510023584 A CN 201510023584A CN 104644456 A CN104644456 A CN 104644456A
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Abstract
The invention relates to a percutaneous absorption soluble preparation paster comprising a soluble preparation paster body and conical bulges which are arranged on the surface of the soluble preparation paster body. The paster provided by the invention is a solid paster prepared from a skin care product, and is in a solid state at normal temperature; because the conical bulges are arranged on the surface of the paster, when the paster is used and the paster is pressed into a skin at a speed of more than 1.1mm/s, the conical bulges can finish a process of piercing a stratum corneum and pierce into the stratum corneum to ensure that active ingredients are in direct contact with a corium layer, and then are dissolved and absorbed by skin tissues, so that the stratum corneum is prevented from blocking the ingredients of the product, and the efficiency of the product is improved.
Description
Technical field
The present invention relates to the instrument used in a kind of Transdermal absorption soluble preparation paster, preparation method and preparation method, belong to skin care field.
Background technology
Emulsifiable paste state process for producing cosmetic traditional at present, mainly by oiliness material, aqueous materials, emulsifying agent and other adjuvant raw materials are fully mixed carries out emulsifying, make it the emulsifiable paste becoming homodisperse oil-in-water type or water-in-oil type, in its preparation process, capital equipment is exactly emulsion tank, namely has the stainless steel reaction tank of chuck structure, and there is the turbine type agitator of band sleeve at center, and have raker stirrer along the inwall of tank, for improving the heat transfer of tank skin.Often a homogenizer is also had, for strengthening the circulation of material in tank and disperseing further and homogenizing in the bottom of emulsion tank.Material was generally first preheating to temperature required before adding emulsion tank in metering basin, also steam can be passed in the chuck of emulsion tank if necessary or hot water heats after adding emulsion tank, discharging after logical water quench in emulsion tank chuck after emulsifying completes, inject basin, in order to packaging.
When cooling procedure, sometimes the method for point tank group is adopted: carry out in the cooling tank moving on to another jacketed and scraper plate agitator by the cooling of emulsifiable paste, this cooling tank often doubles as the use of basin, the cooling for the large production of batch be then after emulsifying completes by material by entering basin after a continuous print tubulation cooler cooling.
Last under the condition of cleaning sterile, cream products is carried out fill and is sealed on special packer, or adopts hand-filling.
Current traditional handicraft is mainly mixing and the cooling of material, and packaging is general adopts glass or plastic bottle packing, transport difficult, cost is higher, and be all generally adopt the mode of smearing to spread upon on the face, active substance is difficult to effectively be absorbed by skin through horny layer, and moist supplementary result is poor.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Transdermal absorption soluble preparation paster, and overcoming skin care item of the prior art is all make emulsifiable paste shape, directly spreads upon skin surface, Transdermal absorption weak effect, and the defect that transport difficult cost is high.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of Transdermal absorption soluble preparation paster, and comprise soluble preparation paster body and taper projection, described taper projection is located at soluble preparation paster body surface.
The invention has the beneficial effects as follows: the solid, shaped paster that paster is made up of skin care item, under room temperature state, it is solid state, because chip surface is arranged with taper projection, during use, during to be pressed into skin more than the speed of 1.1mm/s, taper projection can complete and pierce through cuticular process and thrust horny layer, make active ingredient directly touch in skin corium to dissolve again and absorbed by skin histology, directly avoid the obstruct of horny layer to product composition, improve the efficiency of product.
On the basis of technique scheme, the present invention can also do following improvement.
The present invention's a kind of Transdermal absorption soluble preparation paster described above, further, described soluble preparation paster body thickness is 0.1 ~ 0.5mm; The base diameter of described taper projection is 0.1 ~ 0.2mm, and height is at more than 150um.
The present invention's a kind of Transdermal absorption soluble preparation paster described above, further, described in state taper projection base diameter be 0.15mm, height is at 200um.
The present invention's a kind of Transdermal absorption soluble preparation paster described above, further, described taper projection and soluble preparation paster body are made into integration.
The present invention also provides a kind of preparation method of Transdermal absorption soluble preparation paster, comprises the following steps: step (1) is carried out emulsifying make newborn creamy product by fully mixed for raw material;
The newborn creamy product that step (1) is made by step (2) carries out first time dehumidifier by drying machine and is cooled to 40 ~ 50 DEG C in noble gas, makes in glue strip-shaped product;
The glue strip-shaped product that step (2) is made by step (3) is pressed into through the mould with tapered hole the paster that surface alignment has taper projection;
Surface alignment has the convex surface of the paster of taper projection to be placed on pallet upward by step (4), puts into freezer dryer and carries out secondary dehumidifier and cooling, and temperature is down to room temperature 20 ~ 28 DEG C, forms solid product, vacuum sealed package.
The preparation method of the present invention's a kind of Transdermal absorption soluble preparation paster described above, further, described raw material packet oil scraper material, aqueous materials, emulsifying agent and adjuvant.
The preparation method of the present invention's a kind of Transdermal absorption soluble preparation paster described above, further, described raw material comprises the material of following percentage by weight: 1.0-1.5% vitamin A, 1.0-1.5% vitamin E, 2.5-3% Polyethylene Glycol, 65.0-66.5 Lac regis apis %, 1.0-1.5% fruit acid, 6.0-7.0%1,3-dihydroxy acetone, 0.5-1.0% hyaluronic acid, surplus is anion water.
The present invention also provides mould used in a kind of preparation method of Transdermal absorption soluble preparation paster, comprise upper die and lower die, column and high strong spring, described patrix comprises upper mould cover and pressed part with holes, described upper mould cover both sides have the through hole penetrated for column upper end, and centre has the first inside groove; Described pressed part with holes to embed in described first inside groove and is fixedly connected with described upper mould cover; In the middle of described counterdie, there is the second inside groove; Described column lower end is fixed on the both sides of described counterdie; Described high-strength spring housing is located on the column in the middle of described upper die and lower die.
Mould used in the preparation method of the present invention's a kind of Transdermal absorption soluble preparation paster described above, further, described upper mould cover and counterdie are that mould steel is made, and described pressed part with holes is aviation titanium; The size of described second inside groove and the size of described pressed part with holes mutually adaptive.
Mould used in the preparation method of the present invention's a kind of Transdermal absorption soluble preparation paster described above, further, described pressed part with holes can be circular, square or oval, also can be other shape.
The preparation method of the present invention's a kind of Transdermal absorption soluble preparation paster described above, further, the Hardness Control of described solid product is at Mo Shi 1.8 ~ 2.3.
The present invention, compared with emulsifiable paste shape skin care item of the prior art, has following advantage: the present invention is that raw material composition is controlled.What intercepted by horny layer in Transdermal absorption process due to product composition lacks, and can accomplish the content of distributed in demand active ingredient.
Product is the solid-state of sizing compacting.The loss of production process Raw is minimum, and leftover pieces can repeat to melt row compacting more again, and therefore raw material does not have loss substantially.
The cheap letter of packaging material economizes.Because this patent product is solid-state, only need airtight vacuum to pack, be not afraid of the external force factors such as extruding, collision, therefore do not need special expensive packaging material.
Only need electric power and gnotobasis in production process, raw material also only needs mixing and mechanical compaction process, does not produce waste gas, waste material situation.
Be vacuum solid during this product normal temperature storage, the use of antiseptic in composition, can be reduced in a large number.Therefore the solid paster prepared of the inventive method is as the pure environmental protection of skin care item, no pollution, zero-emission, zero side effect.
Accompanying drawing explanation
Fig. 1 is a kind of Transdermal absorption soluble preparation of the present invention paster enlarged diagram;
Pre-structure schematic diagram installed by mould used in the preparation method of a kind of Transdermal absorption of Fig. 2 the present invention soluble preparation paster;
Fig. 3 is mould mounted configuration schematic diagram used in the preparation method of a kind of Transdermal absorption of the present invention soluble preparation paster.
In accompanying drawing, the list of parts representated by each label is as follows:
1, upper mould cover, 2, pressed part with holes, 3, counterdie, 4, column, 5, high strong spring, 6, soluble preparation paster body, 7, taper is protruding.
Detailed description of the invention
Be described principle of the present invention and feature below in conjunction with accompanying drawing, example, only for explaining the present invention, is not intended to limit scope of the present invention.
As shown in Figure 1, the enlarged diagram of a kind of Transdermal absorption soluble preparation of the present invention paster, comprises soluble preparation paster body 6 and taper projection 7, and described taper projection gathers proper alignment at described soluble preparation paster body surface.
A kind of Transdermal absorption soluble preparation of the present invention paster, one preferred embodiment: described soluble preparation paster body thickness is 0.1 ~ 0.5mm; The base diameter of described taper projection is 0.1 ~ 0.2mm, and height is at more than 150um.
A kind of Transdermal absorption soluble preparation of the present invention paster, another preferred embodiment is: described in state taper projection base diameter be 0.15mm, height is at 200um.
Embodiment 1
The present invention also provides a kind of preparation method of Transdermal absorption soluble preparation paster, comprise the following steps: step (1) is by 1.0% vitamin A, 1.5% vitamin E, 2.5% Polyethylene Glycol, 66.5 Lac regis apis %, 1.5% fruit acid, 7.0%1,3-dihydroxy acetone, 1.0% hyaluronic acid, to be that anion water is fully mixed carry out emulsifying and make emulsifiable paste shape surplus;
The emulsifiable paste shape that step (1) is made by step (2) carries out first time dehumidifier by drying machine and is cooled to 40 ~ 50 DEG C in noble gas, makes in glue strip-shaped product;
The glue strip-shaped product that step (2) is made by step (3) is pressed into through the mould with tapered hole the paster that surface alignment has taper projection;
Surface alignment has the convex surface of the paster of taper projection to be placed on pallet upward by step (4), puts into freezer dryer and carries out secondary dehumidifier and cooling, and temperature is down to room temperature 20 ~ 28 DEG C, forms solid product, vacuum sealed package.
Raw material: 1.0% vitamin A, 1.5% vitamin E, 2.5% Polyethylene Glycol, 66.5 Lac regis apis %, 1.5% fruit acid, 7.0%1,3-dihydroxy acetone, 1.0% hyaluronic acid, to be that anion water is fully mixed carry out skin care item that emulsifying makes emulsifiable paste shape and have and make skin smooth, delicacy surplus, has excellent antioxidation, the effect of whitening and skin-protecting.
Comparative example directly smears mutually commensurability above-mentioned newborn creamy product.
Paster skin care item prepared by the inventive method embodiment 1 and emulsifiable paste shape skin care item, embodiment 1 respectively after 100 personnel continuously 30 days on probation, skin smooth and whitening result as follows:
(using method of paster of the present invention is: product of the present invention is directly attached on the face, and melt and absorb, paster is attached on the face, can to complete pierce through horny layer from mechanics with taper projection during speed press-in skin more than 1.1mm/s; Comparative example is directly spread upon on the face by newborn creamy product.)
Embodiment 2
The present invention also provides a kind of preparation method of Transdermal absorption soluble preparation paster, comprise the following steps: step (1) is by 1.5% vitamin A, 1.5% vitamin E, 3% Polyethylene Glycol, 66.5 Lac regis apis %, 1.5% fruit acid, 7.0%1,3-dihydroxy acetone, 1.0% hyaluronic acid, to be that anion water is fully mixed carry out emulsifying and make emulsifiable paste shape surplus;
The emulsifiable paste shape that step (1) is made by step (2) carries out first time dehumidifier by drying machine and is cooled to 40 ~ 50 DEG C in noble gas, makes in glue strip-shaped product;
The glue strip-shaped product that step (2) is made by step (3) is pressed into through the mould with tapered hole the paster that surface alignment has taper projection;
Surface alignment has the convex surface of the paster of taper projection to be placed on pallet upward by step (4), puts into freezer dryer and carries out secondary dehumidifier and cooling, and temperature is down to room temperature 20 ~ 28 DEG C, forms solid product, vacuum sealed package.
Paster skin care item prepared by the inventive method embodiment 2 and emulsifiable paste shape skin care item, embodiment 2 and comparative example respectively after 100 personnel continuously 30 days on probation, skin smooth and whitening result as follows:
(using method of paster of the present invention is: product of the present invention is directly attached on the face, and melt and absorb, paster is attached on the face, can to complete pierce through horny layer from mechanics with taper projection during speed press-in skin more than 1.1mm/s; Comparative example is directly spread upon on the face by newborn creamy product.)
As can be seen from the above table: paster prepared by embodiment 1 and embodiment 2 has better assimilation effect or infiltrates effect.
As shown in Figure 2, the present invention plants mould used in the preparation method of Transdermal absorption soluble preparation paster, comprise upper die and lower die 3, column 4 and high strong spring 5, described patrix comprises upper mould cover 1 and pressed part with holes 2, described pressed part with holes is square, described upper mould cover 1 both sides have the through hole penetrated for column upper end, and centre has the first inside groove; Described pressed part with holes 2 to embed in described first inside groove and is fixedly connected with described upper mould cover 1; In the middle of described counterdie 3, there is the second inside groove; Described column 4 lower end is fixed on the both sides of described counterdie 3; Described high strong spring 5 is set on the column 4 in the middle of described upper mould cover 1 and counterdie 3.
Described upper mould cover 1 and counterdie 3 are made for mould steel, and described pressed part 2 with holes is aviation titanium; The size of described second inside groove and the size of described pressed part with holes mutually adaptive.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a Transdermal absorption soluble preparation paster, is characterized in that, comprise soluble preparation paster body and taper projection, described taper projection is located at soluble preparation paster body surface.
2. a kind of Transdermal absorption soluble preparation paster according to claim 1, it is characterized in that, described soluble preparation paster body thickness is 0.1 ~ 0.5mm; The base diameter of described taper projection is 0.1 ~ 0.2mm, and height is at more than 150um.
3. a kind of Transdermal absorption soluble preparation paster according to claim 2, is characterized in that, described in state taper projection base diameter be 0.15mm, height is at 200um.
4. a preparation method for Transdermal absorption soluble preparation paster, is characterized in that, comprises the following steps: step (1) is carried out emulsifying make newborn creamy product by fully mixed for raw material;
The newborn creamy product that step (1) is made by step (2) carries out first time dehumidifier by drying machine and is cooled to 40 ~ 50 DEG C in noble gas, makes in glue strip-shaped product;
The glue strip-shaped product that step (2) is made by step (3) is pressed into through the mould with tapered hole the paster that surface has taper projection;
The convex surface of the paster of taper projection is placed on pallet by step (4) upward, puts into freezer dryer and carries out secondary dehumidifier and cooling, and temperature is down to room temperature 20 ~ 28 DEG C, forms solid product, vacuum sealed package.
5. the preparation method of a kind of Transdermal absorption soluble preparation paster according to claim 4, it is characterized in that, the Hardness Control of described solid product is at Mo Shi 1.8 ~ 2.3.
6. the preparation method of a kind of Transdermal absorption soluble preparation paster according to claim 4, is characterized in that, described raw material packet oil scraper material, aqueous materials, emulsifying agent and adjuvant.
7. the preparation method of a kind of Transdermal absorption soluble preparation paster according to claim 4, it is characterized in that, described raw material comprises the material of following percentage by weight: 1.0-1.5% vitamin A, 1.0-1.5% vitamin E, 2-3.5% Polyethylene Glycol, 65.0-66.5 Lac regis apis %, 1.0-1.5% fruit acid, 6.0-7.0%1,3-dihydroxy acetone, 0.5-1.0% hyaluronic acid, surplus is anion water.
8. mould used in the preparation method of Transdermal absorption soluble preparation paster described in an any one of claim 4-7, it is characterized in that, comprise upper die and lower die, column and high strong spring, described patrix comprises upper mould cover and pressed part with holes, described upper mould cover both sides have the through hole penetrated for column upper end, and centre has the first inside groove; Described pressed part with holes to embed in described first inside groove and is fixedly connected with described upper mould cover; In the middle of described counterdie, there is the second inside groove; Described column lower end is fixed on the both sides of described counterdie; Described high-strength spring housing is located on the column in the middle of described upper die and lower die.
9. mould used in the preparation method of a kind of Transdermal absorption soluble preparation paster according to claim 8, it is characterized in that, described upper mould cover and counterdie are that mould steel is made, and described pressed part with holes is aviation titanium; The size of described second inside groove and the size of described pressed part with holes mutually adaptive.
10. mould used in the preparation method of a kind of Transdermal absorption soluble preparation paster according to claim 8, it is characterized in that, described pressed part with holes is circular, square or oval.
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| CN201510023584.9A CN104644456A (en) | 2015-01-16 | 2015-01-16 | Percutaneous absorption soluble preparation paster, preparation method thereof and tool used in preparation method |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101124072A (en) * | 2004-11-26 | 2008-02-13 | 新加坡科技研究局 | Method and device for forming micro-structure |
| WO2009040548A1 (en) * | 2007-09-28 | 2009-04-02 | The Queen's University Of Belfast | Delivery device and method |
| CN101687090A (en) * | 2007-05-15 | 2010-03-31 | 考司美德制药株式会社 | Microneedle device and method for producing the same |
| CN102178616A (en) * | 2011-05-06 | 2011-09-14 | 广州保税区雅兰国际化妆品有限公司 | Hyaluronic acid micro-needle adhesive film and preparation method thereof |
| CN204395037U (en) * | 2015-01-16 | 2015-06-17 | 刘春生 | A kind of Transdermal absorption soluble preparation paster |
-
2015
- 2015-01-16 CN CN201510023584.9A patent/CN104644456A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101124072A (en) * | 2004-11-26 | 2008-02-13 | 新加坡科技研究局 | Method and device for forming micro-structure |
| CN101687090A (en) * | 2007-05-15 | 2010-03-31 | 考司美德制药株式会社 | Microneedle device and method for producing the same |
| WO2009040548A1 (en) * | 2007-09-28 | 2009-04-02 | The Queen's University Of Belfast | Delivery device and method |
| CN102178616A (en) * | 2011-05-06 | 2011-09-14 | 广州保税区雅兰国际化妆品有限公司 | Hyaluronic acid micro-needle adhesive film and preparation method thereof |
| CN204395037U (en) * | 2015-01-16 | 2015-06-17 | 刘春生 | A kind of Transdermal absorption soluble preparation paster |
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Application publication date: 20150527 |