CN112168853A - Coenzyme Q10 pseudo-ginseng composite tablet with antioxidant function and preparation method thereof - Google Patents
Coenzyme Q10 pseudo-ginseng composite tablet with antioxidant function and preparation method thereof Download PDFInfo
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- CN112168853A CN112168853A CN201910605125.XA CN201910605125A CN112168853A CN 112168853 A CN112168853 A CN 112168853A CN 201910605125 A CN201910605125 A CN 201910605125A CN 112168853 A CN112168853 A CN 112168853A
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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Abstract
The invention relates to a coenzyme Q10 pseudo-ginseng composite tablet with an antioxidant function and a preparation method thereof, wherein the composite tablet comprises the following raw materials in percentage by weight: coenzyme Q10: 20% -40%, notoginseng extract: 80% -60%, weighing the above components, mixing, granulating, drying, granulating, mixing, tabletting, coating, selecting, and packaging to obtain the tablet product with effects of resisting oxidation and delaying aging. Compared with the prior art, the invention effectively retains the effective components in the coenzyme Q10, combines the pseudo-ginseng extract, has stronger antioxidant effect, adopts tablets as the preparation form, retains the effective components and covers the smell, and has the advantages of convenient taking, easy swallowing, safe carrying and convenient use.
Description
Technical Field
The invention relates to the field of health care products, in particular to a coenzyme Q10 pseudo-ginseng composite tablet with an antioxidant function and a preparation method thereof.
Background
At present, a plurality of antioxidant products are available in the market, most of the antioxidant products are vitamin C or vitamin E synthetic antioxidant products, the product efficacy is not obvious, the development of novel composite antioxidant products is significant, innovative raw materials can be introduced, and nutrients can be accurately supplemented to achieve the purpose of antioxidation.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a coenzyme Q10 pseudo-ginseng composite tablet with an antioxidant function and a preparation method thereof.
The purpose of the invention can be realized by the following technical scheme:
the coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function comprises the following raw materials in percentage by weight: coenzyme Q10: 20% -40%, notoginseng extract: 80 to 60 percent.
The following raw materials are preferably selected by weight percentage: coenzyme Q10: 28% -35%, notoginseng extract: 72 to 65 percent.
The notoginseng extract is obtained by supercritical extraction.
Chopping plant pseudo-ginseng, soaking the cut plant pseudo-ginseng and ethanol in a container according to the volume ratio of 1:12-15, then placing the container in a supercritical fluid extraction tank, filling high-pressure liquid carbon dioxide, and performing supercritical extraction at the temperature of 32-35 ℃ and the pressure of 73-80bar to obtain the pseudo-ginseng extract.
The coenzyme Q10 is prepared by biological extraction.
Adding 6-10 wt% of pyrogallic acid into yeast, adding a sodium hydroxide-ethanol mixed solvent, wherein the content of sodium hydroxide is 10-15 wt%, controlling the temperature to be 50-60 ℃, stirring, extracting by using petroleum ether, washing to be neutral, and extracting by using absolute ethanol after vacuum concentration to obtain coenzyme Q10.
The preparation method of the coenzyme Q10 pseudo-ginseng composite tablet with the antioxidation function comprises the steps of weighing, burdening, granulating, drying, granulating, totally mixing, tabletting, coating, selecting and packaging the components to obtain the tablet product with the antioxidation and the senescence delaying functions.
The temperature is controlled to be 45-50 ℃ during drying.
The difference of the sheet weight of the prepared composite sheet is not more than 5%.
Compared with the prior art, the invention has the following advantages:
1. by adopting a biological extraction technology, a high-activity coenzyme Q10 product is obtained, effective components in coenzyme Q10 are effectively retained, and the antioxidant effect is stronger by combining a pseudo-ginseng extract.
2. The preparation form is tablet, which not only retains the effective components but also masks the odor, and has the advantages of convenient administration, easy deglutition, safe carrying and convenient use.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.
The coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function comprises the following raw materials in percentage by weight: coenzyme Q10: 20% -40%, notoginseng extract: 80 to 60 percent.
In the raw materials, the pseudo-ginseng extract is obtained by supercritical extraction: chopping plant pseudo-ginseng, soaking the cut plant pseudo-ginseng and ethanol in a container according to the volume ratio of 1:12-15, then placing the container in a supercritical fluid extraction tank, filling high-pressure liquid carbon dioxide, and performing supercritical extraction at the temperature of 32-35 ℃ and the pressure of 73-80bar to obtain the pseudo-ginseng extract.
The coenzyme Q10 is prepared by biological extraction: adding 6-10 wt% of pyrogallic acid into yeast, adding sodium hydroxide-ethanol mixed solvent, stirring at 50-60 deg.C, extracting with petroleum ether, washing with water to neutrality, vacuum concentrating, and extracting with anhydrous ethanol to obtain coenzyme Q10.
The preparation method of the coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function comprises the steps of weighing, burdening, granulating, drying at 45-50 ℃, granulating, totally mixing, tabletting, coating, selecting and packaging the components to obtain the tablet product with the antioxidant and anti-aging functions, wherein the difference of the tablet weight of the composite tablet is not more than 5%.
The following are more detailed embodiments, and the technical solutions and the technical effects obtained by the present invention will be further described by the following embodiments.
Example 1
The coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function comprises the following raw materials in percentage by weight: coenzyme Q10: 20%, notoginseng extract: 80 percent.
In the raw materials, the pseudo-ginseng extract is obtained by supercritical extraction: chopping plant pseudo-ginseng, soaking the cut plant pseudo-ginseng and ethanol in a container according to the volume ratio of 1:12, then placing the container in a supercritical fluid extraction tank, filling high-pressure liquid carbon dioxide, controlling the temperature at 32 ℃ and the pressure at 73bar, and performing supercritical extraction to obtain the pseudo-ginseng extract.
The coenzyme Q10 is prepared by biological extraction: adding 6 wt% of pyrogallic acid into yeast, adding a sodium hydroxide-ethanol mixed solvent, controlling the content of sodium hydroxide to be 10 wt%, stirring at 50 ℃, extracting by using petroleum ether, washing to be neutral, concentrating in vacuum, and extracting by using absolute ethanol to obtain the coenzyme Q10.
The preparation method of the coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function comprises the steps of weighing, burdening, granulating, drying at 45 ℃, granulating, totally mixing, tabletting, coating, selecting and packaging the components to obtain the tablet product with the antioxidant and anti-aging functions, wherein the difference of the tablet weight of the composite tablet is not more than 5%.
Example 2
The coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function comprises the following raw materials in percentage by weight: coenzyme Q10: 28%, notoginseng extract: 72 percent.
In the raw materials, the pseudo-ginseng extract is obtained by supercritical extraction: chopping plant pseudo-ginseng, soaking the cut plant pseudo-ginseng and ethanol in a container according to the volume ratio of 1:14, then placing the container in a supercritical fluid extraction tank, filling high-pressure liquid carbon dioxide, controlling the temperature to be 33 ℃ and the pressure to be 75bar, and carrying out supercritical extraction to obtain the pseudo-ginseng extract.
The coenzyme Q10 is prepared by biological extraction: adding pyrogallic acid 8 wt% into yeast, adding sodium hydroxide-ethanol mixed solvent, wherein the content of sodium hydroxide is 15 wt%, stirring at 50 deg.C, extracting with petroleum ether, washing with water to neutrality, vacuum concentrating, and extracting with anhydrous ethanol to obtain coenzyme Q10.
The preparation method of the coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function comprises the steps of weighing, burdening, granulating, drying at 48 ℃, granulating, totally mixing, tabletting, coating, selecting and packaging the components to obtain the tablet product with the antioxidant and anti-aging functions, wherein the difference of the tablet weight of the composite tablet is not more than 5%.
Example 3
The coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function comprises the following raw materials in percentage by weight: coenzyme Q10: 30%, notoginseng extract: 70 percent.
In the raw materials, the pseudo-ginseng extract is obtained by supercritical extraction: chopping plant pseudo-ginseng, soaking the cut plant pseudo-ginseng and ethanol in a container according to the volume ratio of 1:15, then placing the container in a supercritical fluid extraction tank, filling high-pressure liquid carbon dioxide, and performing supercritical extraction at the temperature of 35 ℃ and the pressure of 80bar to obtain the pseudo-ginseng extract.
The coenzyme Q10 is prepared by biological extraction: adding 10 wt% of pyrogallic acid into yeast, adding a sodium hydroxide-ethanol mixed solvent, controlling the temperature at 60 ℃, stirring, extracting by using petroleum ether, washing to be neutral, concentrating in vacuum, and extracting by using absolute ethanol to obtain coenzyme Q10.
The preparation method of the coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function comprises the steps of weighing, burdening, granulating, drying at 50 ℃, granulating, totally mixing, tabletting, coating, selecting and packaging the components to obtain the tablet product with the antioxidant and anti-aging functions, wherein the difference of the tablet weight of the composite tablet is not more than 5%.
Example 4
The coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function comprises the following raw materials in percentage by weight: coenzyme Q10: 40%, notoginseng extract: 60 percent.
In the raw materials, the pseudo-ginseng extract is obtained by supercritical extraction: chopping plant pseudo-ginseng, soaking the cut plant pseudo-ginseng and ethanol in a container according to the volume ratio of 1:12, then placing the container in a supercritical fluid extraction tank, filling high-pressure liquid carbon dioxide, and performing supercritical extraction at the temperature of 35 ℃ and the pressure of 75bar to obtain the pseudo-ginseng extract.
The coenzyme Q10 is prepared by biological extraction: adding pyrogallic acid 8 wt% into yeast, adding sodium hydroxide-ethanol mixed solvent, wherein the content of sodium hydroxide is 15 wt%, stirring at 55 deg.C, extracting with petroleum ether, washing with water to neutrality, vacuum concentrating, and extracting with anhydrous ethanol to obtain coenzyme Q10.
The preparation method of the coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function comprises the steps of weighing, burdening, granulating, drying at 50 ℃, granulating, totally mixing, tabletting, coating, selecting and packaging the components to obtain the tablet product with the antioxidant and anti-aging functions, wherein the difference of the tablet weight of the composite tablet is not more than 5%.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The embodiments described above are intended to facilitate the understanding and use of the invention by those skilled in the art. It will be readily apparent to those skilled in the art that various modifications to these embodiments may be made, and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above embodiments, and those skilled in the art should make improvements and modifications within the scope of the present invention based on the disclosure of the present invention.
Claims (10)
1. The coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function is characterized by comprising the following raw materials in percentage by weight: coenzyme Q10: 20% -40%, notoginseng extract: 80 to 60 percent.
2. The coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function according to claim 1, wherein the raw materials with the following weight percentage contents are preferably selected: coenzyme Q10: 28% -35%, notoginseng extract: 72 to 65 percent.
3. The coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function according to claim 1 or 2, wherein the pseudo-ginseng extract is obtained by supercritical extraction.
4. The coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function according to claim 3, wherein the plant pseudo-ginseng is chopped, soaked in ethanol according to the volume ratio of 1:12-15, then placed in a supercritical fluid extraction tank, and filled with high-pressure liquid carbon dioxide, and the temperature is controlled to be 32-35 ℃, and the pressure is controlled to be 73-80bar, so as to obtain the pseudo-ginseng extract.
5. The coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function according to claim 1 or 2, wherein the coenzyme Q10 is prepared by biological extraction.
6. The coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function according to claim 5, wherein 6-10 wt% of pyrogallic acid is added to yeast cells, then a sodium hydroxide-ethanol mixed solvent is added, stirring is performed at a temperature of 50-60 ℃, petroleum ether is used for extraction, water washing is performed until the solution is neutral, and the coenzyme Q10 is obtained by extracting with absolute ethanol after vacuum concentration.
7. The coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function according to claim 6, wherein the content of sodium hydroxide in the sodium hydroxide-ethanol mixed solvent is 10-15 wt%.
8. The method for preparing coenzyme Q10 pseudo-ginseng composite tablets with antioxidant function according to claim 1, wherein the tablet product with antioxidant and antiaging effects is prepared by weighing, blending, granulating, drying, grading, totally mixing, tabletting, coating, sorting and packaging the above components.
9. The method for preparing the coenzyme Q10 pseudo-ginseng composite tablet with the antioxidant function according to claim 8, wherein the temperature is controlled to be 45-50 ℃ during drying.
10. The method for preparing coenzyme Q10 pseudo-ginseng composite tablets with antioxidant function according to claim 8, wherein the difference of tablet weight of the prepared composite tablets is not more than 5%.
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| CN201910605125.XA CN112168853A (en) | 2019-07-05 | 2019-07-05 | Coenzyme Q10 pseudo-ginseng composite tablet with antioxidant function and preparation method thereof |
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| CN201910605125.XA CN112168853A (en) | 2019-07-05 | 2019-07-05 | Coenzyme Q10 pseudo-ginseng composite tablet with antioxidant function and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115721587A (en) * | 2022-10-20 | 2023-03-03 | 武汉超爱健康咨询服务有限责任公司 | Collagen compound liquid with skin repairing and anti-aging effects |
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2019
- 2019-07-05 CN CN201910605125.XA patent/CN112168853A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115721587A (en) * | 2022-10-20 | 2023-03-03 | 武汉超爱健康咨询服务有限责任公司 | Collagen compound liquid with skin repairing and anti-aging effects |
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Application publication date: 20210105 |