CN1883439A - Filling biomaterial for beauty treatment, micro-array combination technology and application method thereof - Google Patents
Filling biomaterial for beauty treatment, micro-array combination technology and application method thereof Download PDFInfo
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- CN1883439A CN1883439A CN 200610081584 CN200610081584A CN1883439A CN 1883439 A CN1883439 A CN 1883439A CN 200610081584 CN200610081584 CN 200610081584 CN 200610081584 A CN200610081584 A CN 200610081584A CN 1883439 A CN1883439 A CN 1883439A
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- beauty treatment
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Abstract
Disclosed are a combination technique for aesthetic biological stuffing and micro-needles arrays, and application method thereof, relating to injection of hyaluronic acid, collagen, carnitine, growth hormone, and fibroblast growth factor with micro-needles arrays, is characterizd in that enjecting aesthetic stuffing such as aminopolysaccharide, collagen, carnitine, growth hormone, and fibroblast growth factor into a back lining film with definite quantity, back buckling a micro-needles array chip on biological stuffing, sealing the liner film and the micro-needles array with a shaper, covering needles surface with a protecting film, packing, and obtaining a finished product. The product is used for tissue stuffing and skin wrinkles removing of human faces and necks, mammary enlargement, and hand back skin plumping. The invention is provided with high biological security reliability, an excellent recovery effect, and can be used with simplicity.
Description
Technical field
The present invention relates to a kind of filling beauty treatment biomaterial and microneedle array combination technology and application process thereof.Relate to microneedle array injection hyaluronic acid, collagen protein, carnitine, growth hormone, fibroblast growth factor, make the plump of the breast enlargement of the tissue filling of human face, cervical region and skin wrinkle removing, breast and skin of dorsum of hand.
Background technology
The skin of human body is made up of epidermis and corium.Corium is compact connective, is positioned at the below the epidermis, and except that cell component, main component is biomacromolecule collagen protein, elastin laminin, aminoglycan (transparent fat acid, chondroitin sulfate, keratan sulfate) formation.Modern science proved skin aging, gauffer and collagen protein and elastin laminin damage and aminoglycan appear and minimizing closely related.In order to increase the plump degree of skin, artificial increase aminoglycan composition just becomes inevitable choice.Because hyaluronic acid is made of aminoglycan fully, the specificity that does not have kind, it is again the human body self material, immunogenicity is extremely low, artificial injection hyaluronic acid is filled subcutaneous tissue, usually can not cause the inflammation and the anaphylaxis of surrounding tissue, hyaluronic acid is just as the preferred material of biological filling.And the difference of collagen protein kind is also less, also can be used as artificial packing material.But collagen protein should be done sensitization test earlier as implant.Hyaluronic acid subcutaneous injection implantation comes from Europe and popular in countries such as Japan, Canada, Australia gradually, by the wrinkle gully that the subcutaneous injection hyaluronic acid has been eliminated the injection site, has satisfied the needs of part crowd's beauty treatment substantially.Although report finds to have untoward reaction after the serious injection so far, conventional hyaluronic acid subcutaneous injection also has some drawbacks and deficiency, and these deficiencies have limited the scope of application:
1, because conventional entry needle is bigger, and the syringe needle of different directions is twitched back and forth in the artificial operating process, and subcutaneous tissue has been caused damage to a certain degree, injection people from rear section skin has red and swollen phenomenon, and there is pain at red and swollen position.
2, injection operation people difference, the different injection volumes of its injection maneuver also have than big-difference, lack stabilized quality and guarantee.
3, a pin hole is injected too many biological implant, forms the sealing coat of blister between epidermis and corium, and stiff mask sensation can appear in skin surface.
4, the hyaluronic acid of a large amount of external sources can not form effectively with endogenous biomacromolecule and combine, and experimental results show that the easier degraded of non-binding attitude hyaluronic acid.
5, the implant injection must be carried out in professional institution, uses inconvenience.
In order to overcome the problems referred to above, the new method of a kind of multiple spot micro-injection of filled biomass material injection beauty treatment expectation.The microneedle array medicine-feeding technology appears as the injection beauty treatment and has brought new dawn.The micropin technology just proposed in the seventies in 20th century, but was applied to transdermal delivery system up to micropin in 1998.Its way is, makes the empty micropin array that pin reaches 400 μ m with silicon or metal, the about 100 μ m of pin spacing, and this length can see through epidermis and basement membrane thereof, and the form by paster imports medicine in the skin through micropin.Utilize the micropin technology not only can import small-molecule drug, and can import biomacromolecule class medicine.Up to the present still do not have and see the report that microseism pin row are applied to improve looks.This patent " filled biomass material and microneedle array combination technology " has been opened up new application, and beauty treatment brings earth-shaking variation to non-invasive shaping:
1, because micropin is very thin, almost skin is not caused damage, injection back skin does not have inflammatory reaction, does not have pain yet.
2, the beauty treatment position is accurate, does not have the error of personnel operation.
3, measure little even injection, do not form the sealing coat of blister between epidermis and the corium, stiff mask sensation, facial expression nature can not appear in skin surface.
4, the hyaluronic acid of Wei Liang external source can form useful effect with endogenous biomacromolecule, can activate fibroblast, and positive feedback induces fibroblasts to secrete to produce endogenous hyaluronic acid, collagen protein, elastin laminin.In fact the reparation of the fracture of collagen and hyaluronic acid increase, and except relying on replenishing of external source, self fibroblastic activation has important function.
5, injected material is positioned at subcutaneous shallow-layer, the possibility that does not have injected material and catabolite to enter little blood vessel, the risk of no vascular embolization.
6, need not carry out in professional institution, be easy to use.
The present invention can not once eliminate for the very dark skin part of fold, because wrinkle is the result of long-term skin movements, smooths also process if having time, so take blanking time, repeatedly micropin injection way is eliminated deep wrinkle gradually.
Summary of the invention
The invention provides a kind of production technology of cosmetics.Promptly improve looks filled biomass material and microneedle array combination technology and application process.
Micropin Beauty sticking piece preparation flow:
With filled biomass material 100-1000 μ l calibrated shot on backing film; thick about 50-500 μ m; the micro-needle array chip back of the body is buckled on the filled biomass material; the micro-needle array chip back of the body is buckled on the filled biomass material; forming machine sealing backing film and microneedle array; the dial covered with protective film, package packing machine, finished product.This finished product paster can be used for the plump of the breast enlargement of the tissue filling of human face, cervical region and skin wrinkle removing, breast and skin of dorsum of hand.
Beneficial effect of the present invention:
This product is applicable to the reparation of the tiny early stage variation of skin, and darker wrinkle can adopt at interval and repeatedly repair, and easy to use, this product that contains hyaluronic acid and collagen can be finished the beauty treatment process voluntarily, without any side effect.
The specific embodiment
Embodiment 1,
To fill hyaluronic acid 100-1000 μ l calibrated shot on backing film; thick about 50-500 μ m; the micro-needle array chip back of the body is buckled on the filled biomass material; the micro-needle array chip back of the body is buckled on the filled biomass material; forming machine sealing backing film and microneedle array; the dial covered with protective film, package packing machine, finished product.Human face's skin wrinkle removing is meant the wrinkle that adopts between this product eyebrow; The vertical wrinkles line of long-term smoker mouth; The wrinkle at corners of the mouth place; The wrinkles on one's forehead of forehead; Crows-feet near the eyes; Laugh line between nose and between the corners of the mouth; Cheek portion fold; The lip wrinkle; The acne cicatrix; Other face's cicatrix.Application process is at first to clean up face, cervical region or skin of breast; 70% ethanol is cleaned and is desired lagging skin position for one time, cuts paster from packing, tears the microneedle array protecting film; microneedle array is desired lagging skin position and is thrust in the face of accurate, and finger pushes backing film a few minutes gently and gets final product.
Embodiment 2
To fill hyaluronic acid 100-1000 μ l calibrated shot on backing film; thick about 50-500 μ m; the micro-needle array chip back of the body is buckled on the filled biomass material; the micro-needle array chip back of the body is buckled on the filled biomass material; forming machine sealing backing film and microneedle array; the dial covered with protective film, package packing machine, finished product.Person neck skin wrinkle removing is meant tissue filling and the skin wrinkle removing that adopts this product cervical region.Application process is at first to clean up face, cervical region or skin of breast; 70% ethanol is cleaned and is desired lagging skin position for one time, cuts paster from packing, tears the microneedle array protecting film; microneedle array is desired lagging skin position and is thrust in the face of accurate, and finger pushes backing film a few minutes gently and gets final product.
Embodiment 3
To fill hyaluronic acid 100-1000 μ l calibrated shot on backing film; thick about 50-500 μ m; the micro-needle array chip back of the body is buckled on the filled biomass material; the micro-needle array chip back of the body is buckled on the filled biomass material; forming machine sealing backing film and microneedle array; the dial covered with protective film, package packing machine, finished product., plump being meant of people's hand skin adopted the wrinkle removing of this product to hand skin.Application process is at first to clean up face, cervical region or skin of breast; 70% ethanol is cleaned and is desired lagging skin position for one time, cuts paster from packing, tears the microneedle array protecting film; microneedle array is desired lagging skin position and is thrust in the face of accurate, and finger pushes backing film a few minutes gently and gets final product.
Embodiment 4
To fill hyaluronic acid 100-1000 μ l calibrated shot on backing film; thick about 50-500 μ m; the micro-needle array chip back of the body is buckled on the filled biomass material; the micro-needle array chip back of the body is buckled on the filled biomass material; forming machine sealing backing film and microneedle array; the dial covered with protective film, package packing machine, finished product.The breast enlargement of breast be meant adopt this product blanking time repeatedly micro-injection reach the purpose of Lac regis apis.Application process is at first to clean up face, cervical region or skin of breast; 70% ethanol is cleaned and is desired lagging skin position for one time, cuts paster from packing, tears the microneedle array protecting film; microneedle array is desired lagging skin position and is thrust in the face of accurate, and finger pushes backing film a few minutes gently and gets final product.
Claims (11)
1, a kind of beauty treatment filled biomass material and microneedle array combination technology and application process is characterized in that adopting beauty treatment filled biomass material; Aminoglycan, collagen protein, carnitine, growth hormone, fibroblast growth factor, calibrated shot are on backing film, and the micro-needle array chip back of the body is buckled on the filled biomass material; forming machine sealing backing film and microneedle array; the dial covered with protective film, package packing machine, finished product.This finished product paster can be used for the plump of the breast enlargement of the tissue filling of human face, cervical region and skin wrinkle removing, breast and skin of dorsum of hand.
2, according to described a kind of beauty treatment filled biomass material of claim 1 and microneedle array combination technology, its beauty treatment filled biomass material aminoglycan is to have hyaluronic acid, chondroitin sulfate, keratan sulfate, the heparin that amino disaccharide unit constitutes.
3, its content of aqueous solution, colloidal sol or gel according to claim 1 and 2 described hyaluronic acids, chondroitin sulfate, keratan sulfate, heparin pharmaceutical grade is 1%-100%.
4, according to described a kind of beauty treatment filled biomass material of claim 1 and microneedle array combination technology, its beauty treatment filled biomass material; Each Collagen Type VI of I-X that constitutes by the α peptide chain.
5, be aqueous solution, colloidal sol or gel according to claim 1 and 4 described collagen protein, its content is 1%-100%.
6, according to described a kind of beauty treatment filled biomass material of claim 1 and microneedle array combination technology, aqueous solution, colloidal sol or the gel of its beauty treatment filled biomass material carnitine, its content is 1%-100%.
7, according to described a kind of beauty treatment filled biomass material of claim 1 and microneedle array combination technology, its beauty treatment filled biomass material growth hormone is the human growth hormone, and its aqueous solution content is less than 0.04-0.4U.
8, according to described a kind of beauty treatment filled biomass material of claim 1 and microneedle array combination technology, the aqueous solution of its beauty treatment filled biomass material fibroblast growth factor.
9, according to described a kind of beauty treatment filled biomass material of claim 1 and microneedle array combination technology, present technique is applicable to microneedle array.
10, be polrvinyl chloride, polyethylene, polypropylene, polyester, methylcellulose according to the described backing film material of claim 1.
11, be silication polrvinyl chloride/polyethylene/polyethylene terephthalate according to the described protecting film material of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610081584 CN1883439A (en) | 2006-05-30 | 2006-05-30 | Filling biomaterial for beauty treatment, micro-array combination technology and application method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610081584 CN1883439A (en) | 2006-05-30 | 2006-05-30 | Filling biomaterial for beauty treatment, micro-array combination technology and application method thereof |
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| CN1883439A true CN1883439A (en) | 2006-12-27 |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178616A (en) * | 2011-05-06 | 2011-09-14 | 广州保税区雅兰国际化妆品有限公司 | Hyaluronic acid micro-needle adhesive film and preparation method thereof |
| CN102323398A (en) * | 2011-05-19 | 2012-01-18 | 国家人口计生委科学技术研究所 | Solution for sperm detection |
| CN102686226A (en) * | 2009-05-29 | 2012-09-19 | 思马特斯 | Injectable combination of adrenergic receptor agonists with fillers, for decreasing skin reactions due to injection |
| CN102018655B (en) * | 2009-09-17 | 2014-04-23 | 苏州纳通生物纳米技术有限公司 | Transdermal medicament delivery combined preparation |
| CN103893018A (en) * | 2014-04-16 | 2014-07-02 | 华熙福瑞达生物医药有限公司 | Soluble hyaluronic acid micro-needle patch |
| CN104288129A (en) * | 2014-09-30 | 2015-01-21 | 奥思达干细胞有限公司 | Stem cell micro-needle patch for resisting wrinkles and removing freckles and preparation method thereof |
| CN104434561A (en) * | 2014-11-10 | 2015-03-25 | 广州市博卡利生物科技有限公司 | Micro-needle mask |
| CN104548190A (en) * | 2015-01-27 | 2015-04-29 | 广西达庆生物科技有限公司 | Medical biological implants dressing and preparation method thereof |
| CN105233270A (en) * | 2015-11-12 | 2016-01-13 | 上海昊海生物科技股份有限公司 | Medicine composition for water-optical treatment and application of medicine composition |
| CN108939153A (en) * | 2018-08-17 | 2018-12-07 | 振德医疗用品股份有限公司 | A kind of collagen-based packing material and preparation method thereof and its application method |
| CN114949344A (en) * | 2022-04-13 | 2022-08-30 | 吴力波 | Coating microneedle patch for skin filling |
-
2006
- 2006-05-30 CN CN 200610081584 patent/CN1883439A/en active Pending
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102686226A (en) * | 2009-05-29 | 2012-09-19 | 思马特斯 | Injectable combination of adrenergic receptor agonists with fillers, for decreasing skin reactions due to injection |
| CN102018655B (en) * | 2009-09-17 | 2014-04-23 | 苏州纳通生物纳米技术有限公司 | Transdermal medicament delivery combined preparation |
| CN102178616A (en) * | 2011-05-06 | 2011-09-14 | 广州保税区雅兰国际化妆品有限公司 | Hyaluronic acid micro-needle adhesive film and preparation method thereof |
| CN102178616B (en) * | 2011-05-06 | 2013-06-05 | 广州保税区雅兰国际化妆品有限公司 | Hyaluronic acid micro-needle adhesive film and preparation method thereof |
| CN102323398A (en) * | 2011-05-19 | 2012-01-18 | 国家人口计生委科学技术研究所 | Solution for sperm detection |
| CN102323398B (en) * | 2011-05-19 | 2014-03-12 | 国家人口计生委科学技术研究所 | Solution for sperm detection |
| CN103893018A (en) * | 2014-04-16 | 2014-07-02 | 华熙福瑞达生物医药有限公司 | Soluble hyaluronic acid micro-needle patch |
| CN103893018B (en) * | 2014-04-16 | 2016-02-03 | 华熙福瑞达生物医药有限公司 | A kind of soluble transparent matter acid microneedle patch |
| CN104288129A (en) * | 2014-09-30 | 2015-01-21 | 奥思达干细胞有限公司 | Stem cell micro-needle patch for resisting wrinkles and removing freckles and preparation method thereof |
| CN104434561A (en) * | 2014-11-10 | 2015-03-25 | 广州市博卡利生物科技有限公司 | Micro-needle mask |
| CN104548190A (en) * | 2015-01-27 | 2015-04-29 | 广西达庆生物科技有限公司 | Medical biological implants dressing and preparation method thereof |
| CN104548190B (en) * | 2015-01-27 | 2016-09-07 | 广西达庆生物科技股份有限公司 | A kind of medical bio breast augmentation dressing and preparation method thereof |
| CN105233270A (en) * | 2015-11-12 | 2016-01-13 | 上海昊海生物科技股份有限公司 | Medicine composition for water-optical treatment and application of medicine composition |
| CN108939153A (en) * | 2018-08-17 | 2018-12-07 | 振德医疗用品股份有限公司 | A kind of collagen-based packing material and preparation method thereof and its application method |
| CN114949344A (en) * | 2022-04-13 | 2022-08-30 | 吴力波 | Coating microneedle patch for skin filling |
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Addressee: Meng Yichun Document name: Notification that Application Deemed to be Withdrawn |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20061227 |