CN108653177A - A kind of microneedle patch and preparation method thereof for whitening spot-removing - Google Patents
A kind of microneedle patch and preparation method thereof for whitening spot-removing Download PDFInfo
- Publication number
- CN108653177A CN108653177A CN201810803700.2A CN201810803700A CN108653177A CN 108653177 A CN108653177 A CN 108653177A CN 201810803700 A CN201810803700 A CN 201810803700A CN 108653177 A CN108653177 A CN 108653177A
- Authority
- CN
- China
- Prior art keywords
- microneedle patch
- extract
- solution
- whitening spot
- ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
The embodiment of the present disclosure discloses a kind of microneedle patch and preparation method thereof for whitening spot-removing, it is related to skin care field, the microneedle patch includes body supports ingredient and functional component, and body supports ingredient is made of degradation material, and functional component percentage composition by weight is composed of the following components：Black bearberry leaf extract 10%~30%, pearl powder 15%~25%, licorice 3%~5%, angelica extract 2%~5%, bletilla striata extract 5%~10%, Semen Coicis extract 5%~10%, lemon extract 10%~15%, niacinamide 5%~10%, auxiliary additive 10%~25%.The microneedle patch of the disclosure effectively penetrates keratoderma barrier, as degradation material dissolves in skin rapidly, functional component may be absorbed by skin corium rapidly, it promotes blood circulation, nutrition skin, dermal melanin is effectively inhibited to generate and accumulate, the decomposition and metabolism for accelerating melanin, play the role of skin whitening.
Description
Technical field
This disclosure relates to skin care field, and in particular to a kind of microneedle patch and preparation method thereof for whitening spot-removing.
Background technology
Although currently, there are many kinds of commercially available whitening spot-removing class skin care item, ideal product is less, some products are added to
Heavy metal Hg or lead, mercury compound can reduce melanin production to brighten skin, again by the tyrosinase activity of inhibition skin
Metallic lead and lead compound have certain screening flaw effect, it can also be used to which whitening hides the flaw.These are added to the skin care item of heavy metal
Although can achieve the effect that get instant result, skin irritatin, erythema water are often will appear after using exceeded heavy metal product
Symptom swollen and that a series of caused systems after human body are absorbed by skin, such as neurasthenia, weak, anaemia disease
Shape.The major defect of most of whitening spot-removing class skin care item is that effect is slow and imprecise, also easily causes the skins such as allergy and asks
Topic.On the other hand, due to the obstruction of keratoderma, the simply coated skin care item in skin surface are difficult really to be absorbed, beautiful
Hold effect also to have a greatly reduced quality.
Invention content
In view of the deficiencies in the prior art, the disclosure is designed to provide a kind of microneedle patch for whitening spot-removing
Piece and preparation method thereof has significant whitening effect and safe.
To achieve the above objectives, the disclosure adopts the technical scheme that：A kind of microneedle patch for whitening spot-removing, including
Body supports ingredient and effect ingredient being dispersed in body supports ingredient, the body supports ingredient is by with biocompatibility
Degradation material be made, functional component percentage composition by weight is composed of the following components：Black bearberry leaf extract 10%~
30%, pearl powder 15%~25%, licorice 3%~5%, angelica extract 2%~5%, bletilla striata extract 5%~
10%, Semen Coicis extract 5%~10%, lemon extract 10%~15%, niacinamide 5%~10%, auxiliary additive
10%~25%.
Based on the above technical solution, the auxiliary additive be glycerine, vitamin E, ascorbic acid, allantoin,
Any one or a few mixture in kojic acid, salicylic acid, squalene, polysorbas20, polysorbate40, polysorbate60 and Tween 80.
Based on the above technical solution, the degradation material is that hyaluronic acid, maltose, chitosan, sulfuric acid are soft
Ossein sodium, sodium alginate, amylopectin, polylactic acid, polyglycolic acid, polyethylene glycol oxide, polyacrylic acid, polyacrylamide, poly- (first
Base vinyl ethers/maleic acid) half-ester copolymerization object, polyvinylpyrrolidone, polyethylene glycol, polyvinyl alcohol, hydroxypropyl cellulose, hydroxyl
Any one or a few mixture in ethyl cellulose, hydroxypropyl methyl cellulose, sodium carboxymethylcellulose.
Based on the above technical solution, the body supports ingredient constitutes pedestal and syringe needle, the functional component point
It is dispersed in pedestal and syringe needle.
Based on the above technical solution, the syringe needle is in pyramid, cone or class cone.
Based on the above technical solution, any needle height is 50-1000 μm, and bottom diameter is 50-1000 μm, phase
The distance between two tips of adjacent two syringe needles are 100-2000 μm.
The disclosure additionally provides a kind of preparation method of the microneedle patch for whitening spot-removing, includes the following steps：
(1) Effect raw material solution is prepared：Functional component is added to appropriate distilled water after mixing, is stirred at 60 DEG C molten
Solution is uniformly mixed, and is obtained the solution that functional component mass fraction is 30%, is cooled to room temperature up to Effect raw material solution；
(2) premixed solution is prepared：Degradation material is dissolved in water to obtain body supports solution, then by the main body
It is mixed in effect material solution that support solution is added in step (1), heating stirring is uniform, is cooled to room temperature to obtain pre- miscible
Liquid；
(3) microneedle patch is prepared：By in the premixed solution injection microneedle array mold in step (2), then vacuumizes, do
Stripping is to get to the microneedle patch for whitening spot-removing after dry.
Based on the above technical solution, the degradation material mass fraction in the body supports solution is 10%.
Based on the above technical solution, the microneedle patch for whitening spot-removing obtained is in temperature 15~25
DEG C, sterile packaged is carried out in the confined space under the conditions of humidity 10%~30%.
Black bearberry leaf extract extracts the leaf from black bearberry, is derived from the natural active matter of green plants, it can be oozed rapidly
Enter skin, as important tyrosinase inhibitor, while not influencing cell Proliferation concentration, the work of tyrosinase can be inhibited
Property, the synthesis of DOPA and DOPA quinone is blocked, to inhibit the generation of melanocyte, moreover it is possible to which substantially reduced UV-induced pigment is heavy
It, dispelling stain and freckle, and does not generate the side effects such as toxic, irritation, sensitization to melanocyte, also have simultaneously
It sterilizes, the effect of anti-inflammatory.
Pearl powder main component has the trace element of calcium carbonate, taurine and needed by human body, and contains needed by human body
Amino acids Glycine, methionine, alanine, leucine, glutamic acid etc..Glycine, methionine contribute to comprehensive and lasting
Ground improves skin quality, has nti-freckle, except acne, beauty delay senility, improve human endocrine, boost metabolism, constitutional
Effect.
Radix Glycyrrhizae is clinically most widely used one of traditional Chinese medicine, is a kind of good natural herb medicinal plant.Radix Glycyrrhizae
And its bioactive ingredients of extraction have the function of certain anti-inflammatory, moisturizing, scavenging activated oxygen and protectiving ultraviolet etc., prevent
The effect of ultraviolet light is protected compared with chemically synthesized sun-screening agent, skin irritation and allergic reaction are few, and application is comparatively safe
Reliably.What is more important, Radix Glycyrrhizae and its extract can inhibit tyrosinase, dopachrome interconvertible enzyme (TRP-2) and DHICA
The activity of oxidizing ferment can also play the effect of endothelin antagonist, increase skin total antioxidant capacity, effective scavenging activated oxygen
And its chain reaction effect, thus the formation and transhipment of melanin effectively can be interfered and prevent, inhibit and reduce pigment deposition, reaches
The effect of skin whitening.
Ferulic acid in Radix Angelicae Sinensis is the active ingredient of antioxidation, by directly eliminating free radical, inhibits super oxygen free
Membrane lipid peroxidatio reaction and radical reaction caused by base, and with a variety of mechanism such as biological film phospholipid join protection membrane lipid
Damage of the antagonism free radical to tissue has special efficacy to the dim complexion caused by free radical retardance.Radix Angelicae Sinensis contains 17 kinds of amino acid,
Wherein 7 kinds of threonine, leucine etc. cannot synthesize and essential amino acid for human body, if lacking it, skin if seems thick
Rough more wrinkles.Angelica extract contains the ingredients such as vitamin A, B12, cupreol, and energy ultraviolet light improves the color of face skin
Plain spot.
Contain a large amount of water soluble polysaccharide in the bulb of the bletilla striata, there is the apparent ability for removing free radical, in contrast it is clear
Except activity is height compared with vitamin E, therefore have effects that whitening spot-removing, nutrition skin, delay skin aging, and has to skin
Have that nonirritant, the characteristics such as have no toxic side effect.
Active constituent in coix seed has inhibiting effect to tyrosinase, prevents the generation of melanin, to reach whitening
The effect of skin.Tyrosinase is one critically important enzyme of melanocyte synthesis of melanin, it is that tyrosine is converted into black
The rate-limiting enzyme of element influences formation and the accumulation of melanin, the unconventionality expression excess and catalytic activity liter of human tyrosinase enzyme
Height is the main reason for causing the diseases such as chloasma, freckle, senile plaque and melanoma.
Lemon as the cosmetic good merchantable brand in fruit, because contain abundant Vitamin C and it is calcareous due to as cosmetics and skin care
The raw material of product.Lemon U.S. can be with whitening cleanser, removal color spot, Firm, moisturizing, dispelling fatigue, anti-skin ageing etc..In addition, lemon
In lemon also contain a large amount of tartaric acid ingredient, can cutin-softening layer, remove dead skin, promote skin metabolism, expanded lemon work
For the function of fruit.
Niacinamide also known as niacinamide (NAA), vitamin B3, nicotinic acid.Pass through merely different from other whitening compositions
The activity for inhibiting tyrosinase, the generation for reducing dermal melanin reach skin-whitening or nti-freckle ingredient by restoring pigment, subtract
Lack the deposition of dermal melanin and reach whitening, niacinamide can inhibit the formation of melanin granule, can also be in melanin granule
Cuticula is being gone upward to epidermal cell, when influencing skin color, effectively melanin is being inhibited to be transmitted to horn cell, or even black
Pigment has reached the stage that superficial skin forms color spot, promotes to contain black by accelerating the renewal speed of Skin Cell
The cell detachment of element.
Compared with the prior art, the advantages of the present invention are as follows：
The microneedle patch for whitening spot-removing of the disclosure can effectively penetrate keratoderma barrier, be formed in skin surface
Duct is dissolved in skin rapidly with the degradation material of body supports ingredient, and functional component may be inhaled by skin corium rapidly
It receives, promotes blood circulation, nutrition skin, effectively inhibit dermal melanin to generate and accumulate, accelerate the decomposition and metabolism of melanin,
Play the role of skin whitening, dispelling stain, and safe.
Description of the drawings
Fig. 1 is the microneedle patch schematic diagram for whitening spot-removing in the embodiment of the present disclosure 1；
Fig. 2 is the dermoscopy photo a of the microneedle patch for whitening spot-removing in the embodiment of the present disclosure 5；
Fig. 3 is the dermoscopy photo b of the microneedle patch for whitening spot-removing in the embodiment of the present disclosure 5.
Specific implementation mode
Microneedle array mold used is prepared by the following method to obtain in following embodiment：
By PDMS (dimethyl silicone polymer, Sylgard 184) and curing agent in mass ratio 10:1 is uniformly mixed, and then will
The mixture is poured over microneedles template surface, is evacuated to -0.1~-0.05MPa and removes bubble in mixture, then 75~
3~the 4h that is heating and curing at 80 DEG C makes PDMS cure, and detaches with microneedles template cured PDMS after cooling to get to PDMS micropins
Array mold.
Embodiment 1
The embodiment of the present disclosure provides a kind of microneedle patch for whitening spot-removing, as shown in Figure 1, the microneedle patch includes master
Body support element and functional component, body supports ingredient constitutes pedestal and syringe needle, functional component are dispersed in pedestal and syringe needle.It is main
Body support element is the hyaluronic acid solution made of the hyaluronic acid with biocompatibility, and functional component percentage by weight contains
It measures composed of the following components：10% black bearberry leaf extract, 15% pearl powder, 5% licorice, 5% Radix Angelicae Sinensis carry
Take object, 10% bletilla striata extract, 10% Semen Coicis extract, 10% lemon extract, 10% niacinamide, 5%
Glycerine, 5% vitamin E, 5% ascorbic acid, 5% allantoin and 5% kojic acid.The syringe needle of microneedle patch is in pyramid
Shape, cone or class cone, needle height are 50 μm, and bottom diameter is 50 μm, and the distance between two tips of two neighboring syringe needle are 100 μm.
The preparation method for the microneedle patch for whitening spot-removing that the embodiment of the present disclosure provides, includes the following steps：
(1) microneedle array mold is prepared：By PDMS and curing agent in mass ratio 10:1 is uniformly mixed, then by the mixture
It is poured over microneedles template surface, -0.05MPa is evacuated to and removes bubble in mixture, then be heating and curing 3 at 75~80 DEG C
~4h makes PDMS cure, and detaches with microneedles template cured PDMS after cooling to get to PDMS microneedle array molds；Wherein,
The specification of microneedles template is as follows：The height of any one syringe needle is 50 μm, and bottom diameter is 50 μm, the distance between two tips of two neighboring syringe needle
It is 100 μm；
(2) Effect raw material solution is prepared：Take weight percentage be 10% black bearberry leaf extract, 15% pearl powder,
5% licorice, 5% angelica extract, 10% bletilla striata extract, 10% Semen Coicis extract, 10% lemon
Lemon extract, 10% niacinamide, 5% glycerine, 5% vitamin E, 5% ascorbic acid, 5% allantoin and 5%
The above functional component is tentatively uniformly mixed, adds distilled water and stirring and dissolving is uniformly mixed at 60 DEG C, obtain work(by kojic acid
The solution that composition quality score is 30% is imitated, is cooled to room temperature up to Effect raw material solution；
(3) premixed solution is prepared：Hyaluronic acid is taken to be configured to the hyaluronic acid solution that 100mg mass fractions are 10%, so
It will be mixed in effect material solution that the hyaluronic acid solution is added in 10mg steps (2) afterwards, be heated to 75~80 DEG C, stirring
Uniformly, it is cooled to room temperature up to premixed solution；
(4) microneedle patch is prepared：The PDMS microneedle array mold oxygen plasma treatment 15s that step (1) is obtained, so
The premixed solution that step (3) obtains is injected in the PDMS microneedle array molds afterwards, which is placed on
It in the vacuum environment that temperature is 15 DEG C, vacuum degree is -0.05MPa, is taken out after so that it is completely filled up, then the drying at 15 DEG C
12h then removes PDMS microneedle array molds to get to the microneedle patch for whitening spot-removing；
(5) step (4) obtained microneedle patch is carried out in the confined space under the conditions of 15 DEG C of temperature, humidity 10%
Sterile packaged.
Embodiment 2
The embodiment of the present disclosure provides a kind of microneedle patch for whitening spot-removing, including body supports ingredient and effect at
Point, body supports ingredient constitutes pedestal and syringe needle, functional component are dispersed in pedestal and syringe needle.Body supports ingredient is by having
Chitosan solution made of the chitosan of biocompatibility, functional component percentage composition by weight are composed of the following components：30%
Black bearberry leaf extract, 25% pearl powder, 3% licorice, 2% angelica extract, 5% bletilla striata extract,
5% Semen Coicis extract, 15% lemon extract, 5% niacinamide, 3% glycerine, 1% allantoin, 1% it is anti-
Bad hematic acid and 5% polysorbas20.The syringe needle of microneedle patch is 500 μm in pyramid, cone or class cone, needle height,
Bottom diameter is 500 μm, and the distance between two tips of two neighboring syringe needle are 1000 μm.
The preparation method for the microneedle patch for whitening spot-removing that the embodiment of the present disclosure provides, includes the following steps：
(1) microneedle array mold is prepared：By PDMS and curing agent in mass ratio 10:1 is uniformly mixed, then by the mixture
It is poured over microneedles template surface, -0.08MPa is evacuated to and removes bubble in mixture, then be heating and curing 3 at 75~80 DEG C
~4h makes PDMS cure, and detaches with microneedles template cured PDMS after cooling to get to PDMS microneedle array molds；Wherein,
The specification of microneedles template is as follows：The height of any one syringe needle is 500 μm, and bottom diameter is 500 μm, the tip of two neighboring syringe needle away from
From being 1000 μm；
(2) functional component material solution is prepared：It is 30% black bearberry leaf extract, 25% pearl to take weight percentage
Powder, 3% licorice, 2% angelica extract, 5% bletilla striata extract, 5% Semen Coicis extract, 15% lemon
Lemon extract, 5% niacinamide, 3% glycerine, 1% allantoin, 1% ascorbic acid and 5% polysorbas20, will more than
Functional component is tentatively uniformly mixed, and adds distilled water and stirring and dissolving is uniformly mixed at 60 DEG C, obtain functional component quality
The solution that score is 30% is cooled to room temperature up to Effect raw material solution；
(3) premixed solution is prepared：It takes chitosan to be configured to the chitosan solution that 100mg mass fractions are 10%, then will
It is mixed in effect material solution that the chitosan solution is added in 10mg steps (2), is heated to 75~80 DEG C, stirs evenly,
It is cooled to room temperature up to premixed solution；
(4) microneedle patch is prepared：The PDMS microneedle array mold oxygen plasma treatment 15s that step (1) is obtained, so
The premixed solution that step (3) obtains is injected in the PDMS microneedle array molds afterwards, which is placed on
It places in the vacuum environment that temperature is 15 DEG C, vacuum degree is -0.08MPa, is taken out after so that it is completely filled up, then done at 15 DEG C
Dry 12h then removes PDMS microneedle array molds to get to the microneedle patch for whitening spot-removing；
(5) step (4) obtained microneedle patch is carried out in the confined space under the conditions of 15 DEG C of temperature, humidity 10%
Sterile packaged.
Embodiment 3
The embodiment of the present disclosure provides a kind of microneedle patch for whitening spot-removing, which includes body supports ingredient
And functional component, body supports ingredient constitutes pedestal and syringe needle, functional component are dispersed in pedestal and syringe needle.Body supports ingredient
It is the maltose solution made of the maltose with biocompatibility, functional component percentage composition by weight is by following components group
At：20% black bearberry leaf extract, 20% pearl powder, 5% licorice, 5% angelica extract, 5% the bletilla striata
Extract, 10% Semen Coicis extract, 15% lemon extract, 10% niacinamide, 3% glycerine, 2% Vitamin C
Acid, 2% salicylic acid and 3% polysorbate40.The syringe needle of microneedle patch is in pyramid, cone or class cone, needle height
It it is 1000 μm, bottom diameter is 1000 μm, and the distance between two tips of two neighboring syringe needle are 2000 μm.
The preparation method for the microneedle patch for whitening spot-removing that the embodiment of the present disclosure provides, includes the following steps：
(1) microneedle array mold is prepared：By PDMS and curing agent in mass ratio 10:1 is uniformly mixed, then by the mixture
It is poured over microneedles template surface, then the bubble being evacuated in -0.1MPa removing mixtures is heating and curing at 75~80 DEG C
3~4h makes PDMS cure, and detaches with microneedles template cured PDMS after cooling to get to PDMS microneedle array molds；Wherein,
The specification of microneedles template is as follows：The height of any one syringe needle is 1000 μm, and bottom diameter is 1000 μm, the tip of two neighboring syringe needle
Distance is 2000 μm；
(2) Effect raw material solution is prepared：It is 20% black bearberry leaf extract, 20% pearl to take weight percentage
Powder, 5% licorice, 5% angelica extract, 5% bletilla striata extract, 10% Semen Coicis extract, 15%
Lemon extract, 10% niacinamide, 3% glycerine, 2% ascorbic acid, 2% salicylic acid and 3% polysorbate40, will be with
Upper functional component is tentatively uniformly mixed, and adds distilled water and stirring and dissolving is uniformly mixed at 60 DEG C, obtain functional component matter
The solution that score is 30% is measured, is cooled to room temperature up to Effect raw material solution；
(3) premixed solution is prepared：It takes maltose to be configured to the maltose solution that 100mg mass fractions are 10%, then will
It is mixed in effect material solution that the maltose solution is added in 10mg steps (2), is heated to 75~80 DEG C, stirs evenly,
It is cooled to room temperature up to premixed solution；
(4) microneedle patch is prepared：The PDMS microneedle array mold oxygen plasma treatment 15s that step (1) is obtained, so
The premixed solution that step (3) obtains is injected in the PDMS microneedle array molds afterwards, which is placed on
It in the vacuum environment that temperature is 15 DEG C, vacuum degree is -0.1MPa, takes out after so that it is completely filled up, is then done at 15 DEG C again
Dry 12h then removes PDMS microneedle array molds to get to the microneedle patch for whitening spot-removing；
(5) step (4) obtained microneedle patch is carried out in the confined space under the conditions of 25 DEG C of temperature, humidity 30%
Sterile packaged.
Embodiment 4
The embodiment of the present disclosure provides a kind of microneedle patch for whitening spot-removing, which includes body supports ingredient
And functional component, body supports ingredient constitutes pedestal and syringe needle, functional component are dispersed in pedestal and syringe needle.Body supports ingredient
The polyacrylamide solution made of the polyacrylamide with biocompatibility, functional component percentage composition by weight by with
The following group is grouped as：15% black bearberry leaf extract, 20% pearl powder, 4% licorice, 4% angelica extract,
8% bletilla striata extract, 10% Semen Coicis extract, 15% lemon extract, 8% niacinamide, 6% glycerine, 2%
Salicylic acid, 5% squalene and 3% polysorbate60.The needle height of microneedle patch is 700 μm, and bottom diameter is 450 μm, adjacent
The distance between two tips of two syringe needles are 800 μm.
The preparation method for the microneedle patch for whitening spot-removing that the embodiment of the present disclosure provides, includes the following steps：
(1) microneedle array mold is prepared：By PDMS and curing agent in mass ratio 10:1 is uniformly mixed, then by the mixture
It is poured over microneedles template surface, then the bubble being evacuated in -0.08MPa removing mixtures heats solid at 75~80 DEG C
Changing 3~4h makes PDMS cure, and detaches with microneedles template cured PDMS after cooling to get to PDMS microneedle array molds；Its
In, the specification of microneedles template is as follows：The height of any one syringe needle is 700 μm, and bottom diameter is 450 μm, the point of two neighboring syringe needle
End distance is 800 μm；
(2) Effect raw material solution is prepared：Take weight percentage be 15% black bearberry leaf extract, 20% pearl powder,
4% licorice, 4% angelica extract, 8% bletilla striata extract, 10% Semen Coicis extract, 15% lemon
Extract, 8% niacinamide, 6% glycerine, 2% salicylic acid, 5% squalene and 3% polysorbate60, by above effect
Ingredient is tentatively uniformly mixed, and adds distilled water and stirring and dissolving is uniformly mixed at 60 DEG C, obtain functional component mass fraction
For 30% solution, it is cooled to room temperature up to Effect raw material solution；
(3) premixed solution is prepared：Polyacrylamide is taken to be configured to the polyacrylamide that 100mg mass fractions are 10% molten
Then liquid will mix in effect material solution that the polyacrylamide solution is added in 10mg steps (2), be heated to 75~80
DEG C, it stirs evenly, is cooled to room temperature up to premixed solution；
(4) microneedle patch is prepared：The PDMS microneedle array mold oxygen plasma treatment 15s that step (1) is obtained, so
The premixed solution that step (3) obtains is injected in the PDMS microneedle array molds afterwards, which is placed on
Temperature is 15 DEG C, and vacuum degree is to be taken out after so that it is completely filled up in the vacuum environment of -0.08MPa, then dried at 15 DEG C
12h then removes PDMS microneedle array molds to get to the microneedle patch for whitening spot-removing；
(5) step (4) obtained microneedle patch is carried out in the confined space under the conditions of 20 DEG C of temperature, humidity 18%
Sterile packaged.
Embodiment 5
The embodiment of the present disclosure provides a kind of microneedle patch for whitening spot-removing, which includes body supports ingredient
And functional component, body supports ingredient constitutes pedestal and syringe needle, functional component are dispersed in pedestal and syringe needle.Body supports ingredient
It is the polyvinylpyrrolidonesolution solution made of the polyvinylpyrrolidone with biocompatibility, functional component percentage by weight
Content is composed of the following components：10% black bearberry leaf extract, 20% pearl powder, 5% licorice, 2% Radix Angelicae Sinensis
Extract, 8% bletilla striata extract, 10% Semen Coicis extract, 12% lemon extract, 8% niacinamide, 5%
Glycerine, 5% vitamin E, 5% kojic acid, 5% salicylic acid and 5% Tween 80.The needle height of microneedle patch is 550 μ
M, bottom diameter are 350 μm, and the distance between two tips of two neighboring syringe needle are 600 μm.
The preparation method for the microneedle patch for whitening spot-removing that the embodiment of the present disclosure provides, includes the following steps：
(1) microneedle array mold is prepared：By PDMS and curing agent in mass ratio 10:1 is uniformly mixed, then by the mixture
Be poured over microneedles template surface, be evacuated to -0.08MPa and remove bubble in the mixture, then at 75~80 DEG C plus
3~4h of heat cure makes PDMS cure, and detaches with microneedles template cured PDMS after cooling to get to PDMS microneedle array moulds
Tool；Wherein, the specification of microneedles template is as follows：The height of any one syringe needle is 550 μm, and bottom diameter is 350 μm, two neighboring syringe needle
Distance between two tips be 600 μm；
(2) Effect raw material solution is prepared：Take weight percentage be 10% black bearberry leaf extract, 20% pearl powder,
5% licorice, 2% angelica extract, 8% bletilla striata extract, 10% Semen Coicis extract, 12% lemon
Extract, 8% niacinamide, 5% glycerine, 5% vitamin E, 5% kojic acid, 5% salicylic acid and 5% Tween 80,
The above functional component is tentatively uniformly mixed, distilled water is added and stirring and dissolving is uniformly mixed at 60 DEG C, be configured to effect
The solution that composition quality score is 30% is cooled to room temperature up to Effect raw material solution；
(3) premixed solution is prepared：Polyvinylpyrrolidone is taken to be configured to the polyvinyl pyrrole that 100mg mass fractions are 10%
Then alkanone solution will mix in effect material solution that the polyvinylpyrrolidonesolution solution is added in 10mg steps (2), add
Heat is stirred evenly to 75~80 DEG C, is cooled to room temperature up to premixed solution；
(4) microneedle patch is prepared：The PDMS microneedle array mold oxygen plasma treatment 15s that step (1) is obtained, so
The premixed solution that step (3) obtains is injected in the PDMS microneedle array molds afterwards, which is placed on
It in the vacuum environment that temperature is 15 DEG C, vacuum degree is -0.08MPa, takes out after so that it is completely filled up, is then done at 15 DEG C again
Dry 12h then removes PDMS microneedle array molds to get to the microneedle patch for whitening spot-removing, such as Fig. 2 and Fig. 3 institutes
Show；
(5) obtained microneedle patch is subjected to sterile envelope in the confined space under the conditions of 18 DEG C of temperature, humidity 20%
Dress.
The present invention is not limited to the above-described embodiments, for those skilled in the art, is not departing from
Under the premise of the principle of the invention, several improvements and modifications can also be made, these improvements and modifications are also considered as the protection of the present invention
Within the scope of.The content not being described in detail in this specification belongs to the prior art well known to professional and technical personnel in the field.
Claims (9)
1. a kind of microneedle patch for whitening spot-removing, it is characterised in that：Including body supports ingredient and it is dispersed in body supports
Effect ingredient in ingredient, the body supports ingredient are made of the degradation material with biocompatibility, described effect at
Divide percentage composition by weight composed of the following components：Black bearberry leaf extract 10%~30%, pearl powder 15%~25%, Radix Glycyrrhizae carry
Take object 3%~5%, angelica extract 2%~5%, bletilla striata extract 5%~10%, Semen Coicis extract 5%~10%, lemon
Lemon extract 10%~15%, niacinamide 5%~10%, auxiliary additive 10%~25%.
2. a kind of microneedle patch for whitening spot-removing as described in claim 1, it is characterised in that：The auxiliary additive is
Glycerine, vitamin E, ascorbic acid, allantoin, kojic acid, salicylic acid, squalene, polysorbas20, polysorbate40, polysorbate60 and Tween 80
In any one or a few mixture.
3. a kind of microneedle patch for whitening spot-removing as described in claim 1, it is characterised in that：The degradation material is
Hyaluronic acid, maltose, chitosan, sodium chondroitin sulfate, sodium alginate, amylopectin, polylactic acid, polyglycolic acid, polyoxygenated
Ethylene, polyacrylamide, poly- (methyl vinyl ether/maleic acid) half-ester copolymerization object, polyvinylpyrrolidone, gathers polyacrylic acid
In ethylene glycol, polyvinyl alcohol, hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, sodium carboxymethylcellulose
Any one or a few mixture.
4. a kind of microneedle patch for whitening spot-removing as described in claim 1, it is characterised in that：The body supports ingredient
It constitutes pedestal and syringe needle, the functional component is dispersed in pedestal and syringe needle.
5. a kind of microneedle patch for whitening spot-removing as claimed in claim 4, it is characterised in that：The syringe needle is in pyramid
Shape, cone or class cone.
6. a kind of microneedle patch for whitening spot-removing as claimed in claim 4, it is characterised in that：Any needle height
It it is 50-1000 μm, bottom diameter is 50-1000 μm, and the distance between two tips of two neighboring syringe needle are 100-2000 μm.
7. a kind of preparation method of the microneedle patch as claimed in any one of claims 1 to 6 for whitening spot-removing, feature exist
In including the following steps：
(1) Effect raw material solution is prepared：Functional component is added to appropriate distilled water after mixing, stirring and dissolving is mixed at 60 DEG C
It closes and uniformly obtains the solution that functional component mass fraction is 30%, be cooled to room temperature up to Effect raw material solution；
(2) premixed solution is prepared：Degradation material is dissolved in water to obtain body supports solution, then by the body supports
It is mixed in effect material solution that solution is added in step (1), heating stirring is uniform, is cooled to room temperature to obtain premixed solution；
(3) microneedle patch is prepared：By in the premixed solution injection microneedle array mold in step (2), then vacuumize, after dry
Stripping is to get to the microneedle patch for whitening spot-removing.
8. a kind of preparation method of microneedle patch for whitening spot-removing as claimed in claim 7, it is characterised in that：The main body
It is 10% to support the degradation material mass fraction in solution.
9. a kind of preparation method of microneedle patch for whitening spot-removing as claimed in claim 7, it is characterised in that：Obtained institute
It states and carries out nothing in the confined space under the conditions of 15~25 DEG C of temperature, humidity 10%~30% for the microneedle patch of whitening spot-removing
Bacterium encapsulates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810803700.2A CN108653177A (en) | 2018-07-20 | 2018-07-20 | A kind of microneedle patch and preparation method thereof for whitening spot-removing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810803700.2A CN108653177A (en) | 2018-07-20 | 2018-07-20 | A kind of microneedle patch and preparation method thereof for whitening spot-removing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108653177A true CN108653177A (en) | 2018-10-16 |
Family
ID=63788467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810803700.2A Pending CN108653177A (en) | 2018-07-20 | 2018-07-20 | A kind of microneedle patch and preparation method thereof for whitening spot-removing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108653177A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700691A (en) * | 2019-03-06 | 2019-05-03 | 大连理工大学 | A kind of microneedle patch of compensating water and removing wrinkle and preparation method thereof |
| CN111544593A (en) * | 2019-03-26 | 2020-08-18 | 华中科技大学同济医学院附属协和医院 | Microneedle patch carrying anti-psoriasis systemic drug and preparation method thereof |
| CN118649122A (en) * | 2024-08-19 | 2024-09-17 | 广州金御化妆品有限公司 | Preparation powder of freckle-removing whitening skin care product and mixer thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105581975A (en) * | 2014-11-10 | 2016-05-18 | （株）设模磊 | Micro-needle and micro-needle patch |
| CN107375008A (en) * | 2017-07-19 | 2017-11-24 | 广州新济药业科技有限公司 | Soluble microneedle patch for whitening and preparation method thereof |
| CN108245481A (en) * | 2018-01-12 | 2018-07-06 | 南京工业大学 | Microneedle and microneedle patch |
-
2018
- 2018-07-20 CN CN201810803700.2A patent/CN108653177A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105581975A (en) * | 2014-11-10 | 2016-05-18 | （株）设模磊 | Micro-needle and micro-needle patch |
| CN107375008A (en) * | 2017-07-19 | 2017-11-24 | 广州新济药业科技有限公司 | Soluble microneedle patch for whitening and preparation method thereof |
| CN108245481A (en) * | 2018-01-12 | 2018-07-06 | 南京工业大学 | Microneedle and microneedle patch |
Non-Patent Citations (1)
| Title |
|---|
| 刘利萍: "《实用美容药物基础》", 31 May 2012, 重庆大学出版 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700691A (en) * | 2019-03-06 | 2019-05-03 | 大连理工大学 | A kind of microneedle patch of compensating water and removing wrinkle and preparation method thereof |
| CN111544593A (en) * | 2019-03-26 | 2020-08-18 | 华中科技大学同济医学院附属协和医院 | Microneedle patch carrying anti-psoriasis systemic drug and preparation method thereof |
| CN118649122A (en) * | 2024-08-19 | 2024-09-17 | 广州金御化妆品有限公司 | Preparation powder of freckle-removing whitening skin care product and mixer thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104173251B (en) | A kind of bone glue of yak former peptide cleawhite pack and preparation method thereof | |
| CN108904421A (en) | A kind of microneedle patch and preparation method thereof for anti-ageing smoothing wrinkle | |
| CN104856892A (en) | Cosmetic or skin care product preparation rich in growth factors and preparation method therefor | |
| CN104971029A (en) | Whitening mask and preparation method thereof | |
| CN1367680A (en) | Pre-formed gel sheet | |
| CN108653177A (en) | A kind of microneedle patch and preparation method thereof for whitening spot-removing | |
| KR20110086894A (en) | Cosmetic included to alkaline powder & solution of shell | |
| CN101730689A (en) | 6 -acyloxy- 7-meth0xy- 2, 2 -dimethylchromane compounds and their use as pigmentation-regulators | |
| CN108852963A (en) | A kind of microneedle patch and preparation method thereof for replenishing water and preserving moisture | |
| CN105380830A (en) | Composition capable of removing pockmarks and inhibiting acne generation, and application thereof | |
| CN108524357A (en) | A kind of fresh and alive beautiful fine flour frost of the root extract containing Aplotaxis auriculata and preparation method thereof | |
| CN102335107A (en) | Application of Chinese yam in preparing whitening products | |
| CN105232426A (en) | Beautifying composition capable of tendering skin rapidly and application of beautifying composition | |
| CN103892269A (en) | Black medlar sun-screening and whitening tablet | |
| JP4244093B2 (en) | Whitening cosmetics | |
| CN102327200A (en) | Whitening and freckle-removing product and preparation method thereof | |
| CN110368339A (en) | Face mask of traditional Chinese medicine composition and preparation method thereof, application method | |
| CN103371962A (en) | Manufacturing method of silkworm chrysalis composite mask powder | |
| CN105726400A (en) | Preparation method of whitening and skincare biological dressings | |
| JP4993391B2 (en) | Slimming application agent for slimming method | |
| CN101647958B (en) | Application of conic gymnadenia rhizome in restraining synthesis of skin melanin | |
| CN111265642A (en) | External medicine for removing nevus, wart and sweat duct tumor and preparation method thereof | |
| KR100867509B1 (en) | A mask pack containing kochiae fructus and a manufacturing method thereof | |
| CN110960480A (en) | Freckle-removing essence containing umbilical cord extract and preparation method thereof | |
| CN107224417B (en) | Chlorella facial mask and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181016 |