CN107375008A - Soluble microneedle patch for whitening and preparation method thereof - Google Patents
Soluble microneedle patch for whitening and preparation method thereof Download PDFInfo
- Publication number
- CN107375008A CN107375008A CN201710591732.6A CN201710591732A CN107375008A CN 107375008 A CN107375008 A CN 107375008A CN 201710591732 A CN201710591732 A CN 201710591732A CN 107375008 A CN107375008 A CN 107375008A
- Authority
- CN
- China
- Prior art keywords
- whitening
- soluble
- microneedle patch
- hyaluronic acid
- needle point
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of soluble microneedle patch for whitening and preparation method thereof.The soluble microneedle patch includes needle point and substrate, and the needle point is prepared by the raw material of following parts by weight：15 30 parts of 1 part of ursin, hyaluronic acid or its salt, 5 25 parts of excipient material；The hyaluronic acid or its salt are hyaluronic acid or Sodium Hyaluronate；The excipient material is selected from least one of fructose, mannose, sodium carboxymethylcellulose and hydroxypropyl methylcellulose.The soluble microneedle patch has good mechanical strength, hardness and dissolubility, avoids the drawbacks of traditional skin care mode can not play ursin advantage, has significant desalination color spot, the effect of skin whitening.
Description
Technical field
The present invention relates to skin care field, more particularly to a kind of soluble microneedle patch for whitening and its preparation side
Method.
Background technology
Microneedle cutaneous technology is that with percutaneous rush to ooze technical research in microelectromechanical systems process technology increasingly mature
Under conditions of a kind of novel medicine feeding mode for growing up.Microneedle array have yardstick is small, intensity is high, accurately control be pierced into position
Put with depth, it is painless the advantage such as puncture, available for the percutaneous dosing of chemicals, albumen, vaccine etc., before there is greatly development
Scape.Micropin technology is not only widely used in biomedical sector, is even more received in beauty treatment fields unprecedented
Heat is held in both hands, and micropin beauty widely uses on America and Europe, Japan, South Korea and other places.Micropin is quite varied in the purposes of beauty treatment fields, and it was both
It is moulding to can be used for body beautification, can be used for face and skin beautifying, also has good effect to hair growth, reparation bubble trace etc.；Total
For, application of the micropin in terms of beauty treatment can be summarised as the following aspects：To anti aging effect, prevention and treatment
Alopecia, lose weight, treat acne, remove dry addiction of dead skin tissue, the local accumulation for reducing fat, skin etc..
However, popular beauty micropin is to use the nondegradable solid microneedles of biology mostly in recent years, such as micropin roller,
The U.S. modeling of micropin, nanometer micropin etc., bring some unfavorable factors, such as to consumer：First, high cost high price.Second, peace
Quan Xing.There is metal micro-needle, or monocrystalline silicon micropin in existing market, but due to micropin itself it is tiny the characteristics of, by contrast
Intensity decreases, easy fracture cause lower layers of skin inflammation to damage, and metal material causes apparent pain inside skin
Sense, or some are manufactured using other materials, and human body is damaged, and frequent use can cause pore increase, pigmentation；Doctor
If treating mechanism micropin roller to share, instrument just has an opportunity to remain his human blood, and being easily caused AIDS, hepatitis etc. must propagate.The
Three, practicality.Current most of beauty micropin products can only be realized in beauty mechanism or hospital by professional or professional people
Member instructs lower use, or because the security that technical reason causes to use can not ensure, causes the operation difficulty of micropin big, just
Profit is relatively low.
The defects of exactly compensate for current micropin beauty that emerge of soluble micropin, hyaluronic acid micropin are exactly wherein one
Kind.Micropin is prepared by matrix of hyaluronic acid, after it is pierced into human body skin, hyaluronic acid dissolves under humoral effect to be stranded in
In skin, beautification function can be not only played, and because hyaluronic acid is human endogenous's property material, inflammatory will not be caused anti-
Should.But the mechanical strength of soluble micropin that some cosmetic active agents are prepared with hyaluronic acid is poor, has been not enough to
Effect punctures cuticula and produces medicament transport microchannel, and therefore, the mechanical strength for improving soluble micropin at present is still micropin system
A great problem in agent R＆D process.
The content of the invention
Based on this, the invention provides a kind of soluble microneedle patch for whitening, the soluble micropin has good
Hardness and mechanical strength, can effectively puncture cuticula produce medicament transport microchannel, whitening active ingredients are transferred to skin
Under, make it have significant whitening effect.
Concrete technical scheme is as follows：
A kind of soluble microneedle patch for whitening, including needle point and substrate, the needle point by following parts by weight original
Material is prepared：
1 part of ursin
Hyaluronic acid or its salt 15-30 parts
Excipient material 5-25 parts；
The hyaluronic acid or its salt are hyaluronic acid or Sodium Hyaluronate；
The excipient material in fructose, mannose, sodium carboxymethylcellulose and hydroxypropyl methylcellulose at least one
Kind；The substrate is prepared by water-soluble high-molecular material.
In wherein some embodiments, the needle point is prepared by the raw material of following parts by weight：
1 part of ursin
Hyaluronic acid or its salt 20-24 parts
Excipient material 8-22 parts.
In wherein some embodiments, the needle point is prepared by the raw material of following parts by weight：
1 part of ursin
Hyaluronic acid or its salt 21-23 parts
Excipient material 14-19 parts.
In wherein some embodiments, the needle point is prepared by the raw material of following parts by weight：
1 part of ursin
Hyaluronic acid or its salt 21-23 parts
Excipient material 17.5-18.5 parts.
In wherein some embodiments, the excipient material is selected from fructose, mannose, sodium carboxymethylcellulose and hydroxypropyl
At least two in methylcellulose.
In wherein some embodiments, the excipient material is made up of component A and component B, the component A be fructose and/
Or mannose, the component B are sodium carboxymethylcellulose and/or hydroxypropyl methylcellulose.
In wherein some embodiments, the mass ratio of the component A and component B are 3-9:1.
In wherein some embodiments, the excipient material is 4-9 by mass ratio:1 fructose and sodium carboxymethylcellulose
Composition.
In wherein some embodiments, the excipient material is 6-9 by mass ratio:1 fructose and sodium carboxymethylcellulose
Composition.
In wherein some embodiments, the excipient material is 7.5-8.5 by mass ratio:1 fructose and carboxymethyl cellulose
Plain sodium composition.
In wherein some embodiments, the molecular weight of the hyaluronic acid or its salt is 1500kDa-2500kDa.
In wherein some embodiments, the water-soluble high-molecular material is selected from polyvinyl alcohol and its derivative, polyethylene
At least one in pyrrolidones and its derivative, hyaluronic acid or its salt, lactose, D-sorbite, glucan, trehalose and sucrose
Kind.
In wherein some embodiments, the water-soluble high-molecular material is hyaluronic acid or its salt.
Present invention also offers the preparation method of the above-mentioned soluble microneedle patch for whitening.
Concrete technical scheme is as follows：
A kind of preparation method of the above-mentioned soluble microneedle patch for whitening, comprises the following steps：
The excipient material is soluble in water, the hyaluronic acid or its salt are added, is stirred, adds the black bearberry
Glycosides, stir, de-bubbled, obtain needle point liquid；The water-soluble high-molecular material is soluble in water, obtain substrate liquid；By needle point liquid
Inject in micropin mould, centrifugation, then substrate liquid is laid on needle point liquid, centrifuge, dry water removal, produce.
In wherein some embodiments, the total concentration of raw material is 24-35wt% in the needle point liquid, and the raw material refers to institute
State ursin, excipient material and hyaluronic acid or its salt.
In wherein some embodiments, the concentration of water-soluble high-molecular material is 2-4wt% in the substrate liquid.
In wherein some embodiments, the rotating speed of the centrifugation is 2000-3000rpm, and temperature is 0-8 DEG C, centrifugation when
Between be 1-3min.
Ursin is derived from the natural active matter of green plants, can effectively suppress the tyrosine in melanocyte in skin
The activity of enzyme, the formation of melanin is blocked, so as to reduce Skin pigmentation, dispelling stain and freckle, and to melanocyte
Toxicity is low.But the present inventor is had found by furtheing investigate, ursin is because strongly hydrophilic and keratoderma
The reasons such as obstruction cause its skin permeation rates relatively low, and ursin active component can not be efficiently transferred to subcutaneously, and ursin should have
Whitening effect can not play completely, whitening effect is not notable.The present invention is further by furtheing investigate from a large amount of macromolecule materials
Screening obtains particular kind of excipient material of the present invention in material, by ursin and hyaluronic acid and the particular types and
The excipient material mixture of dosage is prepared into the good soluble microneedle patch of mechanical strength, can effectively utilize soluble micropin
Yardstick it is small, intensity is high, accurately controls and is pierced into the advantages such as position and depth, painless puncture, abolish the barrier of keratoderma
Effect, is remarkably improved the skin permeation amount of ursin, whitening active factor ursin is directly delivered to subcutaneously, avoids biography
System mode can not play the drawbacks of ursin advantage, give play to the whitening effect of ursin to greatest extent.
Soluble microneedle patch for whitening of the present invention and preparation method thereof has advantages below and beneficial effect：
The present invention is by by ursin and hyaluronic acid or its salt and the excipient material mixture system of particular types and dosage
The standby soluble microneedle patch for whitening formed with good mechanical strength, with enough hardness, be advantageous to be pierced into
Skin, it is not easily broken simultaneously, can effectively punctures keratoderma and produce medicament transport microchannel, by the whitening active factor
Ursin is transferred to subcutaneously；The dissolubility of micropin needle body is good simultaneously, can dissolve in skin rapidly and quickly be absorbed by human body,
With biocompatibility and the advantages of good security.The soluble microneedle patch for whitening of the present invention avoids traditional skin care
Mode can not play the drawbacks of ursin advantage, have significant desalination color spot, the effect of skin whitening.
Soluble microneedle patch for whitening is prepared in the formula of the present invention, had in its preparation process suitable viscous
Degree, be advantageous to micropin shaping.
Embodiment
Soluble microneedle patch for whitening and preparation method thereof of the present invention is done below in conjunction with specific embodiment into
One step is described in detail.
Embodiment 1
The soluble microneedle patch for whitening prepared with different prescriptions, each composition of raw materials are as shown in table 1：
The composition of raw materials of 1 soluble microneedle patch of table
Note：HA refers to hyaluronic acid, and its molecular weight is 2000kDa.
Preparation method is as follows：
Each raw material is weighed according to the raw material shown in table 1 and its proportioning to be placed in right amount in 10ml centrifuge tubes, with raw material gross mass
2.5 times of purified water is solvent, is vortexed and mixes dissolving, and 8 kinds of needle point liquid are configured by the prescription of table 1.Needle point liquid is drawn with syringe to note
In a subtle way in needle mould tool, every 500 μ l needle point liquid of injection, pave, 3000rpm is centrifuged in refrigerated centrifuge (temperature is 4 DEG C)
2min, unnecessary needle point liquid is drawn, 1000 μ l substrates liquid (Sodium Hyaluronates (molecular weight 200kDa) are drawn with syringe:Water=1:
30 (mass ratioes)) it is laid on needle point liquid, 2000rpm centrifuges 2min in refrigerated centrifuge (temperature is 4 DEG C), takes out, normal
Dry 24 hours, take out in warm drying equipment, peel off mould, obtain being prepared with above-mentioned 8 kinds of prescription raw materials 8 kinds are used for U.S.
White soluble microneedle patch.
Embodiment 2
The hardness and ductility of 8 kinds of soluble microneedle patch for being used for whitening prepared by testing example 1.
Microneedle patch needle point is positioned over upwards on horizontal test platform, by P/6 type tack stainless steel cylindrical probes,
With stable 0.1mm/sec speed, excitation force 0.05N, apply axially vertical power, set location parameter such as table 2.Analyzer is remembered
Mechanical change of the record probe contacts needle point during reaching preset height (400 μm of micropin height).
The test parameter of table 2
After the completion of test, the micropin sample tested on microscope carrier is taken out, with micro- sem observation Texture instrument probe active force
Afterwards, micropin local form changes.
3 are the results are shown in Table using what Texture instrument tested micropin hardness, ductility prepared by different prescriptions.
The hardness and ductility of the different prescription micropins of table 3
Soluble micropin needle point bears active force during being pushed by texture instrument probe and not broken ability can be made
For the intensity of micropin, intensity is more high, and the pressure that micropin is born is bigger, and pressure size is as a ginseng for characterizing micropin hardness
Number.During being pressed down, elastic deformation and plastic deformation occur micropin due to the effect from external force for micropin needle body, and two
Person's deformation size, which can characterize micropin, to bear transforming by external force and not broken characteristic, and pass through instrumental test micropin
Ductility, represent micropin needle body before stress produces rupture, its be plastically deformed ability.So in actual application
In, the micropin mechanical performance of intensity and the ductility sign of micropin, the intensity of micropin is bigger, and the power being broken is bigger,
Ductility is better, and its is not easy to break, and mechanical performance is higher, but considers that micropin hardness is to wear from microneedle transdermal delivery purpose
The necessary principal element of transdermal, ductility are only used as aiding in sexual factor.
Experimental result finds that hardness is sequentially：F7>F1>F4>F2>F3>F8>F6>F5, ductility are sequentially：F5>F2>F1
>F3>F7>F6>F8>F4。
F1~F3 is contrasted, only changes the content of fructose, on stiffening effect, with the decline of fructose content,
Prepared micropin sample hardness also declines therewith, and this shows that the addition of fructose contributes to micropin sample to lift hardness；For prolonging
Malleability, as HA in prescription：Fructose：Sodium carboxymethylcellulose：Ursin is 22:12:2:When 1, its micropin sample prepared has
Optimal ductility, and hardness now is also higher, i.e., proportioning has been issued to optimal synergy herein, has optimal strong
Degree.
And in F1, F4, F5 comparison, the difference of three is whether add high polymer adjuvant sodium carboxymethylcellulose,
Can be obtained from the result of hardness and ductility, three in ductility, with sodium carboxymethylcellulose in prescription ratio plus
Greatly, prepared micropin sample ductility is on the rise, shows that being added with for sodium carboxymethylcellulose carries beneficial to micropin sample
Rise ductility；And in the comparison of hardness, as HA in prescription：Fructose：Sodium carboxymethylcellulose：Ursin is 22:16:2:When 1,
Its micropin sample prepared has optimal hardness, and ductility now is also fine, i.e., proportioning has been issued to optimal association herein
Same effect.
And in F1 and F6 comparison, the difference of the two is the difference of composition fructose and mannose, in hardness and prolongs
It can be drawn in the result of malleability, the F1 containing fructose is superior to the F6 containing mannose, this molecular structure and property with the two
The difference of matter is relevant.
In F1 and F7 comparison, the F7 containing hydroxypropyl methylcellulose is in terms of hardness with containing sodium carboxymethylcellulose
F1 is suitable, but F1 is worse than in ductility.
Without addition excipient material in prescription F8, therefore prepared micropin sample is remote poor in hardness and ductility
In other prescriptions, the requirement for effectively piercing through skin is not reached.
To sum up, the hardness of soluble micropin prepared by F1 and F2 and ductility are all preferable, are better than other prescriptions and prepare
Soluble micropin.
The solubility test of 3 soluble microneedle patch of embodiment
The gelatin of precision weighing different quality, purified water, sucrose are prepared in the ratio of table 4, are placed in 50ml centrifuge tubes, 90 DEG C
Dissolve, centrifuge overnight in water-bath, degassing, fast transfer cooling, is frozen into the bright of different moisture content into transparent culture dish
Glue sucrose gelinite.
The gelatin gel body composition of table 4 forms
The 8 kinds of soluble microneedle patch prepared in embodiment 1 are inserted into gel surfaces along culture dish edge, from side
Observed with electron microscope in different time points, record the dissolving situation of different time points, observation is to without clearly visible micropin body
As dissolving terminal, take out micropin and further look at confirmation dissolution time point under the microscope.Soluble micropin is in different water cut
Dissolubility in amount gelatin is shown in Table 5, and due to the physiology framework of skin, the hierarchy of layer of skin is using cuticula as outermost layer, is contained
Water minimum about 20%, inwardly there are hyaline layer, stratum granulosum, stratum spinosum epidermidis, basalis successively, each layer accounting is in skin surface ratio
Difference, and the more internally higher closer tissue water content about 70% or so of moisture, so by different layers accounting root
It is classified as according to skin epidermis anatomical structure ratio：Cuticula：Hyaline layer：Stratum granulosum：Stratum spinosum epidermidis：Basalis=2:1.5:2.5:3:
1, it is specified that different dissolution times and the comprehensive dissolution time of percentage multiplication sum conduct of the different numbers of plies, can synthetically be evaluated external
The dissolution time of dissolution time and prediction micropin in vivo.That is overall merit dissolution time=t30 × 20%+t40 × 15%+
T50 × 25%+t60 × 30%+t70 × 10%.
The dissolubility of the soluble micropin insertion gelatin of 5 different prescriptions of table
The synthesis dissolution time size of micropin prepared by different prescriptions:F8>F2>F3>F7>F4>F6>F1>F5, pass through contrast
It was found that prescription F1, F4-F6 and F7 external comprehensive dissolution time are all controlled in 40min or so, the dissolving phase compared with other prescriptions
To very fast.Found from composition, between F1-F3, with the change of fructose ratio in prescription, the comprehensive dissolution in vitro time
It is varied from, wherein F2 and F3 the dissolution in vitro time are closer to, and the F1 dissolution in vitro time is better than the above two.This be by
Mutual active force is different and cause moisture in absorption gelatin when fructose and the other materials of different proportion are in dissolving
Ability has larger difference.In addition, found in F1, F4 and F5 comparison, with sodium carboxymethylcellulose in prescription ratio
Rising, the dissolution in vitro time of micropin progressively declines, this strong water absorbing capacity with sodium carboxymethylcellulose in gelatin
Relevant, more sodium carboxymethylcellulose accountings accelerates prescription when the water absorbing capacity of gelatin causes faster dissolution in vitro
Between, but all in all, difference is little.And in F1, F6 and F7 comparison, F6 and F7 has used mannose and hydroxypropyl respectively
Methylcellulose, as a result find that F6 and F7 has a small amount of lifting than the F1 dissolution in vitro times, this is mainly due to different material bright
Caused by water absorbing capacity difference in glue.And F8 is the micropin sample without addition excipient material, the results showed that comprehensive dissolution time
With there is obvious extension compared with other prescriptions, it is seen then that the addition of excipient material has for the dissolution in vitro time of micropin sample
Obvious influence, the addition of excipient material is remarkably improved the dissolubility of micropin.
Hardness and ductility result in integrated embodiment 2, the hardness and mechanical strength and dissolubility of F1 micropins are very
It is good, most useful for the application of the soluble micropin as whitening.
The soluble microneedle patch whitening effect of embodiment 4 is investigated
The whitening and skin-protecting effect of soluble microneedle patch for whitening prepared by the prescription 1 of testing example 1.
Method of testing：The people of subject 48, age are 25-45 year, and there is color spot in face.Above-mentioned microneedle patch is pressed and is pierced into
At face's color spot of subject, removed after 4 hours, weekly using twice.
Test result：There are obvious whitening spot-removing effect, after 4 weeks, the face of 48 people using 48 people after one week
Portion's color spot is significantly improved, desalinated, and after 8 weeks, face's color spot of 43 people disappears substantially.
Each technical characteristic of the upper embodiment can be combined arbitrarily, to make description succinct, not to above-mentioned implementation
The all possible combination of each technical characteristic in example is all described, as long as however, the combination of these technical characteristics is not present
Contradiction, all it is considered to be the scope of this specification record.
Embodiment described above only expresses the several embodiments of the present invention, and its description is more specific and detailed, but simultaneously
Can not therefore it be construed as limiting the scope of the patent.It should be pointed out that come for one of ordinary skill in the art
Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of soluble microneedle patch for whitening, it is characterised in that including needle point and substrate, the needle point is by following heavy
The raw material of amount part is prepared：
1 part of ursin
Hyaluronic acid or its salt 15-30 parts
Excipient material 5-25 parts；
The hyaluronic acid or its salt are hyaluronic acid or Sodium Hyaluronate；
The excipient material is selected from least one of fructose, mannose, sodium carboxymethylcellulose and hydroxypropyl methylcellulose；Institute
Substrate is stated to be prepared by water-soluble high-molecular material.
2. the soluble microneedle patch according to claim 1 for whitening, it is characterised in that the needle point is by following heavy
The raw material of amount part is prepared：
1 part of ursin
Hyaluronic acid or its salt 20-24 parts
Excipient material 8-22 parts.
3. the soluble microneedle patch according to claim 1 for whitening, it is characterised in that the excipient material is by group
Divide A and component B compositions, the component A is fructose and/or mannose, and the component B is sodium carboxymethylcellulose and/or hydroxypropyl
Methylcellulose.
4. the soluble microneedle patch according to claim 3 for whitening, it is characterised in that the component A and component B
Mass ratio be 3-9:1.
5. the soluble microneedle patch according to claim 4 for whitening, it is characterised in that the excipient material is by matter
It is 4-9 to measure ratio:1 fructose and sodium carboxymethylcellulose composition.
6. the soluble microneedle patch according to claim 5 for whitening, it is characterised in that the excipient material is by matter
It is 6-9 to measure ratio:1 fructose and sodium carboxymethylcellulose composition.
7. the soluble microneedle patch for whitening according to claim any one of 1-6, it is characterised in that described transparent
The molecular weight of matter acid or its salt is 1500kDa-2500kDa.
8. the soluble microneedle patch for whitening according to claim any one of 1-6, it is characterised in that described water-soluble
Property high polymer material be selected from polyvinyl alcohol and its derivative, polyvinylpyrrolidone and its derivative, hyaluronic acid or its salt, breast
At least one of sugar, D-sorbite, glucan, trehalose and sucrose.
9. a kind of preparation method of the soluble microneedle patch for whitening described in any one of claim 1-8, its feature exist
In comprising the following steps：The excipient material is soluble in water, the hyaluronic acid or its salt are added, stirs, adds
The ursin, stirs, de-bubbled, obtains needle point liquid；The water-soluble high-molecular material is soluble in water, obtain substrate liquid；
Needle point liquid is injected in micropin mould, centrifugation, then substrate liquid is laid on needle point liquid, centrifuged, dried water removal, produce.
10. the preparation method of the soluble microneedle patch according to claim 9 for whitening, it is characterised in that described
The total concentration of raw material is 24-35wt% in needle point liquid, the raw material refer to the ursin, excipient material and hyaluronic acid or its
Salt；And/or the concentration of water-soluble high-molecular material is 2-4wt% in the substrate liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710591732.6A CN107375008B (en) | 2017-07-19 | 2017-07-19 | Soluble microneedle patch for whitening and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710591732.6A CN107375008B (en) | 2017-07-19 | 2017-07-19 | Soluble microneedle patch for whitening and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107375008A true CN107375008A (en) | 2017-11-24 |
| CN107375008B CN107375008B (en) | 2020-07-10 |
Family
ID=60335722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710591732.6A Active CN107375008B (en) | 2017-07-19 | 2017-07-19 | Soluble microneedle patch for whitening and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107375008B (en) |
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653177A (en) * | 2018-07-20 | 2018-10-16 | 华中科技大学同济医学院附属协和医院 | A kind of microneedle patch and preparation method thereof for whitening spot-removing |
| CN108721204A (en) * | 2018-06-04 | 2018-11-02 | 南京紫源康医药科技有限公司 | A kind of solubility alkannin microneedle patch and preparation method thereof |
| CN108888577A (en) * | 2018-09-11 | 2018-11-27 | 无锡元旭生物技术有限公司 | A kind of solubility sodium hyaluronate beauty microneedle patch and preparation method thereof |
| CN108904299A (en) * | 2018-07-20 | 2018-11-30 | 珀莱雅化妆品股份有限公司 | A kind of soluble micropin and preparation method thereof with acne-removing |
| CN109045460A (en) * | 2018-08-28 | 2018-12-21 | 杜玉堂 | A kind of microneedle patch and preparation method thereof |
| CN109199953A (en) * | 2018-10-22 | 2019-01-15 | 海南师范大学 | A kind of Noni fruit ferment eye patch and preparation method thereof |
| CN109420250A (en) * | 2018-02-11 | 2019-03-05 | 西南民族大学 | A kind of new type microneedle and preparation method thereof |
| CN110037938A (en) * | 2019-03-06 | 2019-07-23 | 胡婧 | A kind of hyaluronic acid micro-needle patch and preparation method thereof |
| CN110384620A (en) * | 2019-08-14 | 2019-10-29 | 无锡元旭生物技术有限公司 | Symwhite-337 microneedle patch and preparation method thereof |
| CN110496096A (en) * | 2018-05-17 | 2019-11-26 | 何浩明 | Soluble micropin eye sticker and preparation method thereof |
| CN110664646A (en) * | 2019-11-14 | 2020-01-10 | 广州新济薇娜生物科技有限公司 | Composition with whitening effect, high-drug-loading-rate whitening soluble microneedle patch and preparation method thereof |
| CN110755529A (en) * | 2019-12-05 | 2020-02-07 | 广州新济薇娜生物科技有限公司 | Microneedle patch for improving skin acne and preparation method thereof |
| CN110917066A (en) * | 2019-11-21 | 2020-03-27 | 广州新济薇娜生物科技有限公司 | Wrinkle-removing microneedle patch with high-load macromolecular hyaluronic acid and/or sodium salt particles thereof and preparation method thereof |
| CN111053715A (en) * | 2019-10-22 | 2020-04-24 | 广东雅姿精化有限公司 | High-molecular soluble microneedle and production method thereof |
| CN111184942A (en) * | 2020-03-18 | 2020-05-22 | 四川大学华西医院 | Soluble microneedle for treating chloasma |
| CN111920699A (en) * | 2020-09-14 | 2020-11-13 | 广州新济薇娜生物科技有限公司 | Whitening and freckle-removing composition, whitening and freckle-removing soluble microneedle patch and preparation method thereof |
| CN112274447A (en) * | 2020-10-14 | 2021-01-29 | 杭州奥得科技有限公司 | Dendrobium officinale polysaccharide-hyaluronic acid soluble microneedle and preparation method thereof |
| CN112472660A (en) * | 2019-09-12 | 2021-03-12 | 中科微针（北京）科技有限公司 | Azelaic acid-containing microneedle patch and preparation method thereof |
| CN113081895A (en) * | 2021-05-06 | 2021-07-09 | 无锡元旭生物技术有限公司 | Soluble noninvasive microneedle patch for removing chloasma and preparation method thereof |
| CN113749978A (en) * | 2021-10-09 | 2021-12-07 | 红色未来科技(北京)有限公司 | Soluble microneedle water-light preparation based on whitening effect and preparation method |
| CN115475325A (en) * | 2022-09-09 | 2022-12-16 | 无锡市觉新生物科技有限公司 | Novel tranexamic acid hyaluronic acid microneedle for treating chloasma and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178616A (en) * | 2011-05-06 | 2011-09-14 | 广州保税区雅兰国际化妆品有限公司 | Hyaluronic acid micro-needle adhesive film and preparation method thereof |
| CN103893018A (en) * | 2014-04-16 | 2014-07-02 | 华熙福瑞达生物医药有限公司 | Soluble hyaluronic acid micro-needle patch |
| CN104027324A (en) * | 2013-03-06 | 2014-09-10 | 中国科学院理化技术研究所 | Soluble microneedle vaccine patch and preparation method thereof |
| CN104066475A (en) * | 2012-02-17 | 2014-09-24 | 考司美德制药株式会社 | Microneedle of short-time dissolution type |
| CN104095761A (en) * | 2013-04-08 | 2014-10-15 | 上海汇林医药科技有限公司 | Polymer microneedle patch and application thereof |
| CN105434332A (en) * | 2015-12-02 | 2016-03-30 | 江汉大学 | Preparation method for water-soluble biological macromolecular microneedle membrane |
| CN105581975A (en) * | 2014-11-10 | 2016-05-18 | （株）设模磊 | Micro-needle and micro-needle patch |
| WO2016076615A1 (en) * | 2014-11-10 | 2016-05-19 | 주식회사 스몰랩 | Micro needle patch |
-
2017
- 2017-07-19 CN CN201710591732.6A patent/CN107375008B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178616A (en) * | 2011-05-06 | 2011-09-14 | 广州保税区雅兰国际化妆品有限公司 | Hyaluronic acid micro-needle adhesive film and preparation method thereof |
| CN104066475A (en) * | 2012-02-17 | 2014-09-24 | 考司美德制药株式会社 | Microneedle of short-time dissolution type |
| CN104027324A (en) * | 2013-03-06 | 2014-09-10 | 中国科学院理化技术研究所 | Soluble microneedle vaccine patch and preparation method thereof |
| CN104095761A (en) * | 2013-04-08 | 2014-10-15 | 上海汇林医药科技有限公司 | Polymer microneedle patch and application thereof |
| CN103893018A (en) * | 2014-04-16 | 2014-07-02 | 华熙福瑞达生物医药有限公司 | Soluble hyaluronic acid micro-needle patch |
| CN105581975A (en) * | 2014-11-10 | 2016-05-18 | （株）设模磊 | Micro-needle and micro-needle patch |
| WO2016076615A1 (en) * | 2014-11-10 | 2016-05-19 | 주식회사 스몰랩 | Micro needle patch |
| CN105434332A (en) * | 2015-12-02 | 2016-03-30 | 江汉大学 | Preparation method for water-soluble biological macromolecular microneedle membrane |
Cited By (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109420250A (en) * | 2018-02-11 | 2019-03-05 | 西南民族大学 | A kind of new type microneedle and preparation method thereof |
| CN110496096A (en) * | 2018-05-17 | 2019-11-26 | 何浩明 | Soluble micropin eye sticker and preparation method thereof |
| CN108721204A (en) * | 2018-06-04 | 2018-11-02 | 南京紫源康医药科技有限公司 | A kind of solubility alkannin microneedle patch and preparation method thereof |
| CN108904299B (en) * | 2018-07-20 | 2021-06-18 | 珀莱雅化妆品股份有限公司 | Soluble microneedle with acne removing effect and preparation method thereof |
| CN108904299A (en) * | 2018-07-20 | 2018-11-30 | 珀莱雅化妆品股份有限公司 | A kind of soluble micropin and preparation method thereof with acne-removing |
| CN108653177A (en) * | 2018-07-20 | 2018-10-16 | 华中科技大学同济医学院附属协和医院 | A kind of microneedle patch and preparation method thereof for whitening spot-removing |
| CN109045460A (en) * | 2018-08-28 | 2018-12-21 | 杜玉堂 | A kind of microneedle patch and preparation method thereof |
| CN109045460B (en) * | 2018-08-28 | 2021-08-03 | 江苏熙美生物科技有限公司 | Microneedle patch and preparation method thereof |
| CN108888577A (en) * | 2018-09-11 | 2018-11-27 | 无锡元旭生物技术有限公司 | A kind of solubility sodium hyaluronate beauty microneedle patch and preparation method thereof |
| CN109199953A (en) * | 2018-10-22 | 2019-01-15 | 海南师范大学 | A kind of Noni fruit ferment eye patch and preparation method thereof |
| CN109199953B (en) * | 2018-10-22 | 2021-11-16 | 海南师范大学 | Noni enzyme eye mask and preparation method thereof |
| CN110037938A (en) * | 2019-03-06 | 2019-07-23 | 胡婧 | A kind of hyaluronic acid micro-needle patch and preparation method thereof |
| CN110384620A (en) * | 2019-08-14 | 2019-10-29 | 无锡元旭生物技术有限公司 | Symwhite-337 microneedle patch and preparation method thereof |
| CN112472660A (en) * | 2019-09-12 | 2021-03-12 | 中科微针（北京）科技有限公司 | Azelaic acid-containing microneedle patch and preparation method thereof |
| CN112472660B (en) * | 2019-09-12 | 2022-08-09 | 中科微针（北京）科技有限公司 | Azelaic acid-containing microneedle patch and preparation method thereof |
| CN111053715A (en) * | 2019-10-22 | 2020-04-24 | 广东雅姿精化有限公司 | High-molecular soluble microneedle and production method thereof |
| CN110664646A (en) * | 2019-11-14 | 2020-01-10 | 广州新济薇娜生物科技有限公司 | Composition with whitening effect, high-drug-loading-rate whitening soluble microneedle patch and preparation method thereof |
| CN110664646B (en) * | 2019-11-14 | 2022-04-29 | 广州新济薇娜生物科技有限公司 | Composition with whitening effect, high-drug-loading-rate whitening soluble microneedle patch and preparation method thereof |
| CN110917066A (en) * | 2019-11-21 | 2020-03-27 | 广州新济薇娜生物科技有限公司 | Wrinkle-removing microneedle patch with high-load macromolecular hyaluronic acid and/or sodium salt particles thereof and preparation method thereof |
| CN110917066B (en) * | 2019-11-21 | 2022-12-16 | 广州新济薇娜生物科技有限公司 | Wrinkle-removing microneedle patch with high-load macromolecular hyaluronic acid and/or sodium salt particles thereof and preparation method thereof |
| CN110755529A (en) * | 2019-12-05 | 2020-02-07 | 广州新济薇娜生物科技有限公司 | Microneedle patch for improving skin acne and preparation method thereof |
| CN111184942A (en) * | 2020-03-18 | 2020-05-22 | 四川大学华西医院 | Soluble microneedle for treating chloasma |
| CN111920699A (en) * | 2020-09-14 | 2020-11-13 | 广州新济薇娜生物科技有限公司 | Whitening and freckle-removing composition, whitening and freckle-removing soluble microneedle patch and preparation method thereof |
| CN111920699B (en) * | 2020-09-14 | 2022-10-04 | 广州新济薇娜生物科技有限公司 | Whitening and freckle-removing composition, whitening and freckle-removing soluble microneedle patch and preparation method thereof |
| CN112274447A (en) * | 2020-10-14 | 2021-01-29 | 杭州奥得科技有限公司 | Dendrobium officinale polysaccharide-hyaluronic acid soluble microneedle and preparation method thereof |
| CN112274447B (en) * | 2020-10-14 | 2023-03-10 | 杭州奥得科技有限公司 | Dendrobium officinale polysaccharide-hyaluronic acid soluble microneedle and preparation method thereof |
| CN113081895A (en) * | 2021-05-06 | 2021-07-09 | 无锡元旭生物技术有限公司 | Soluble noninvasive microneedle patch for removing chloasma and preparation method thereof |
| CN113749978A (en) * | 2021-10-09 | 2021-12-07 | 红色未来科技(北京)有限公司 | Soluble microneedle water-light preparation based on whitening effect and preparation method |
| CN115475325A (en) * | 2022-09-09 | 2022-12-16 | 无锡市觉新生物科技有限公司 | Novel tranexamic acid hyaluronic acid microneedle for treating chloasma and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107375008B (en) | 2020-07-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107375008A (en) | Soluble microneedle patch for whitening and preparation method thereof | |
| CN107184417B (en) | Soluble micro-needle patch and preparation method thereof | |
| Xie et al. | Enhanced in vitro efficacy for inhibiting hypertrophic scar by bleomycin-loaded dissolving hyaluronic acid microneedles | |
| Wei et al. | Hydrogel-based microneedles of chitosan derivatives for drug delivery | |
| CN104095761A (en) | Polymer microneedle patch and application thereof | |
| CN104921961B (en) | A kind of degradable biological microneedle patch of multiple-effect reparation | |
| CN108403617A (en) | Triamcinolone acetonide solubility micropin and preparation method thereof | |
| CN104644461A (en) | Application of compound with effect of promoting synthetic activity of collagen in anti-aging cosmetics | |
| CN104288129A (en) | Stem cell micro-needle patch for resisting wrinkles and removing freckles and preparation method thereof | |
| CN112641656A (en) | Polypeptide microneedle and preparation method thereof | |
| CN112516449B (en) | Soluble microneedle array and preparation method thereof | |
| CN111107897B (en) | Hyaluronic acid filler using microneedle patch | |
| KR20110112643A (en) | Skin care melting roots mircroneedle patch and the processing method thereof | |
| Lv et al. | Collagen‐based dissolving microneedles with flexible pedestals: A transdermal delivery system for both anti‐aging and skin diseases | |
| Liu et al. | Fabrication of rapidly separable microneedles for transdermal delivery of metformin on diabetic rats | |
| CN112336749A (en) | Stem cell exosome microneedle patch for removing freckles and wrinkles and preparation method thereof | |
| Zhou et al. | Bletilla striata polysaccharide microneedle for effective transdermal administration of model protein antigen | |
| Chen et al. | Layered GelMA/PEGDA hydrogel microneedle patch as an intradermal delivery system for hypertrophic scar treatment | |
| CN116763716B (en) | Bletilla polysaccharide microneedle carrying ginsenoside Rg3 and preparation method and application thereof | |
| Jeong et al. | Polyvinylpyrrolidone based graphene oxide hydrogels by radiation crosslinking for conductive microneedle patches | |
| Ling et al. | Self‐Healing Porous Microneedles Fabricated Via Cryogenic Micromoulding and Phase Separation for Efficient Loading and Sustained Delivery of Diverse Therapeutics | |
| Huang et al. | [Retracted] Application of Cross‐Linked and Non‐Cross‐Linked Hyaluronic Acid Nano‐Needles in Cosmetic Surgery | |
| CN115531237A (en) | Acne-removing repairing composition, acne-removing repairing microneedle patch and preparation method and application of acne-removing repairing microneedle patch | |
| CN114869841A (en) | Superstrong microneedle patch carrying stem cell active biological factors and large-dose triamcinolone acetonide and preparation method thereof | |
| CN114366700B (en) | Plum slice borneol-flavored soluble micro-needle eye patch for removing pouch and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |