CN103892269A - Black medlar sun-screening and whitening tablet - Google Patents

Abstract

The invention discloses a black medlar sun-screening and whitening tablet belonging to a high-end health care food, and particularly relating to a high-end health-care food prepared from raw materials of black medlar, rutin, tea polyphenol, glutathione, L-cysteine, ellagic acid, ceramide, carotenoids, vitamins and the like as natural pollution-free high-quality medicines and food dual-purpose raw materials in the Qinghai-Tibet plateau. The black medlar sun-screening and whitening tablet has the effects of resisting oxidation, scavenging free radicals, moisturizing, screening sun, resisting ultraviolet irradiation, removing freckles, whitening, smoothing skin wrinkles, delaying the skin ageing and the like. The making process of the black medlar sun-screening and whitening tablet comprises the steps: mixing the raw materials, stirring, tabletting, checking, and packaging.

Description

The sun-proof whitening sheet of black matrimony vine

One, technical field: the invention belongs to high-end health food, especially with raw materials such as the black matrimony vine of the natural pollution-free high-quality medicine and food raw materials in Qinghai-Tibet Platean, rutin, Tea Polyphenols, glutathione, Cys, ellagic acid, ceramide, lycopene, vitamin C, vitamin Es, the health food that adopts advanced technologies to process.

Two, background technology: the health food that this invention forms with Raw material processings such as black matrimony vine, rutin, Tea Polyphenols, glutathione, Cys, ellagic acid, ceramide, lycopene, vitamins.The effects such as that this product has is anti-oxidant, remove free radical, replenishing water and preserving moisture, sun-proof, ultraviolet radiation resisting, nti-freckle, whitening, open and flat wrinkle of skin, delay skin aging.Also do not have in the market this product to occur, this product of innovation research and development can be the new product that a kind of high-quality is provided to all Mies of liking to be beautiful.This product is tablet, belongs to pure natural, without any side effects, taking convenience, successful.

Three, summary of the invention: beauty is the dream that every Ms dreams of.Along with the fast development of China's economy, environmental pollution, atmospheric ozone layer attenuation, ultraviolet ray is irradiated more and more stronger.To skin damage the strongest be exactly solar ulatraviolet radiation, more than 90% skin is aging ahead of time, chloasma etc. are all exposed to the sun and are caused by sunlight, collagen in ultraviolet ray meeting acceleration skin and the decomposition of elastin laminin, infringement is " light aging " like this, the grievous injury that it causes skin, when serious, can directly cause cutaneum carcinoma, light result is that skin causes and occurs in advance wrinkle, sunburn, pigmented spots, the egg of blushing, dry skin, skin aging, coarse, cataract etc., also can cause vision disorder, body immunity disorder, certain this cancer etc.According to external, if do not note at ordinary times sun-proof being old for one's age 10 years old.Therefore, this product of innovation research and development has special effect to like to be beautiful Ms and other crowds.In daily life, because the method such as parasol and sun care preparations is to be difficult to stop the infringement of deep layer ultraviolet ray to skin, this is the one of the main reasons that skin is had a negative impact, and particularly skin head ought be wherein.

Four, composition of raw materials: 0.5 kilogram of 30 kilograms of black wolfberry fruit extract, 2.5 kilograms of rutins, Tea Polyphenols double centner, 12.5 kilograms of glutathione, 50 kilograms of Cys, 50 kilograms of ellagic acids, 40 kilograms of ceramides, 0.16 kilogram of lycopene, 30 kilograms of vitamin Cs, vitamin E are raw material.

Five, technical scheme:

(1), black wolfberry fruit extract: (Lyciam barbarnm extraat), black matrimony vine is to be grown in Qinghai-Tibet green ecological environment, the black matrimony vine dry fruit of pure natural treasure medicine food dual purpose plant.Black matrimony vine is the high-end invigorant of a kind of ecosystem of rare preciousness.Black matrimony vine is matrimony vine of solanaceae plant ripening fruits.Property is put down, and taste is sweet.Return liver, kidney channel.There is effect of nourishing liver and kidney, benefiting shrewd head, moistening lung.For consumptive disease essence lose, soreness of waist and knee joint, dizzy tinnitus, interior heat are quenched one's thirst, the deficiency of blood is sallow, improve eyesight, blurred vision is not clear etc.Modern medicine study thinks, black matrimony vine has the immunity of enhancing, antifatigue, hypotensive, reducing blood lipid, hypoglycemic, protection liver, fat-reducing, the function such as anti-ageing, anticancer.

Chemical composition: black matrimony vine is containing trace elements such as the multivitamins such as polysaccharide, amino acid, betaine, carrotene, Cobastab, vitamin C, nicotinic acid and manganese, chromium, zinc, copper, magnesium, calcium, germanium, cobalts.And also have abundant natural procyanidins, wherein procyanidin content is the several times of blueberry content, is the wild plant of finding that up to now procyanidin content is the highest.

Pharmacological action: 1, strengthen immunity: mouse gavaging water extract or intramuscular injection alcohol extract all can significantly strengthen the phagocytic activity of its reticuloendothelial system to india ink.Water extract or LBP-X all can promote lysozyme activity in Phagocytosis By The Peritoneal Macrophages In Mice and serum.Give normal or Aged Mice gavages or abdomen LBP-X, can significantly strengthen peritoneal macrophage c ₃the acceptor number of b and Fc and vigor, can make Aged Mice suppressor T lymphocyte regulate antibody function to return to the level of adult mice.Black LBP-X sterling has more significant immune response effect than crude product, every immune indexes (comprise immune organ quality, the macrophage phagocytic effect of nospecific immunity, the serum hemolysin of specific humoral immunity, moving back hair style allergy, lymphocyte transformation rate, E rosette formation etc. in specific cellular immunity) all has significant difference.

2, protection liver, AFL: black wolfberry fruit extract has certain effect to protection liver and AFL tool.Modern medicine study is found, contains a kind of active ingredient-betaine in black matrimony vine, and it is very effective to treatment liver diseases.Experiment shows, betaine has the fat of inhibition to deposit in liver cell, promotes the effect of liver cell regeneration.In addition, the middle betaine of black matrimony vine can prevent excess fat storage in liver, has the effect of anti-fatty liver, it is reported, feeds water extract or betaine feed to ccl for a long time through rat ₄the hepatic lesion causing has protective effect, can obviously reduce the variation of lipid in transaminase and liver, can suppress lipidosis and promotion liver cell new life in liver, and to hepatic lipid peroxidation, damage has significant protective effect.

3, promote hematopoiesis, black matrimony vine extract can make in normal mouse marrow burst forming unit erythroid（BFU E） and red be that colony forming unit rises; Can promote mouse spleen T lymphocytic emiocytosis colony stimulating factor, improve mouse colony stimulating activity level; Cultivating is in vitro not that black wolfberry fruit extract can strengthen the colony stimulating activity of colony stimulating factor.Also can promote the propagation of Bone Marrow Hematopoietic Stem Cells of Mice, obviously increase marrow monosystem cell quantity, promote CFU-GM to the differentiation of grain system.

4, beautifying face and moistering lotion: black matrimony vine can suppress lipid and deposit in liver, promotes liver cell new life's effect, and the beauty treatment such as the OPC containing in black matrimony vine, carrotene, vitamin C composition, has moist skin, the look of preserving youthful looks, the good merchantable brand of beauty treatment.Black matrimony vine also can be improved the ability to take oxygen of skin, can play a part skin whitening.According to external, Britain and French scientist research are found, contain a kind of material of not meeting in black matrimony vine, are named as " vitamin of preserving youthful looks ".So black matrimony vine has extremely strong beautifying face and moistering lotion effect.

5, sun-proof, whitening: research performance, black matrimony vine has very strong sun-proof whitening function.Studies confirm that, the generation of the OPC energy restraint of tyrosinase in black matrimony vine, effectively prevents the generation of freckle, chloasma, and the melanin that can control generates.Can also suppress UV-induced pigmentation.Thereby reach the effect of skin-whitening.Multinomial zoopery discovery, black matrimony vine contributes to prevent that ultraviolet ray from causing skin oxidation, alleviates dermatitis and edema that sunburn skin causes.

6, promote skin-tightening elasticity, in black matrimony vine, OPC has the generation of blocking-up skin Elastic protease, and can protect the collagen of skin corium; prevent decomposition, the sex change of collagen; improve for want of elastin laminin and therefore loose skin, can make skin consolidation flexible.Black matrimony vine also can prevent from generating too early wrinkle of skin, and long-term use is skin smooth and flexible.

7, anti-inflammatory antiallergy: histamine can cause allergic and red and swollen, OPC is a kind of natural antihistaminic, has excellent antiphlogistic effects, can prevent the effect of inflammation after allergic and Exposure to Sunlight.

(2), rutin (Rutin), have another name called rutin, citrin.Extensively to be present in the Flavonoids from Plants such as various mushy fruits.Many studies show that, rutin can reduce the effect of vasopermeability and fragility, protection and restoration capillary elasticity; Be used for preventing and treating hypertension, cerebral hemorrhage, DRP.There is anti-inflammatory, antiallergy, sun-proof uvioresistant, diuresis, reducing blood lipid, eliminating chloasma, whitening, alleviate pain, antibechic, the effect such as hypotensive.

Physiological function: 1, anti-inflammatory: studies show that, rats by intraperitoneal injection has obvious inhibitory action to the inflammatory process of implanting wool ball, and the sodium sulfovinate of rutin has very strong antiinflammatory action to the hot edema of rat.

2, remove free radical: rutin has very strong effect of scavenging radical, oxygen molecule is the O ion producing in single electron reduction with the oxygen molecule of single electron form reduction in cellular metabolism, in body, can produce H2O2 and the very big OH free radical of toxicity, therefore damage the soft degree of skin, even accelerate the degree of aging of skin.Research discovery, the rutin active oxygen radical that significantly scavenger-cell produces, up to 78.1%, is far longer than vitamin E to Oi clearance rate.

3, sun-proof uvioresistant: rutin has very strong sun-proof ultraviolet effect, protects effect that skin is injury-free and repair injured skin cell.Rutin has anti-oxidation efficacy, can promote the effect of skin sparing enzyme, can protect Skin Cell to avoid ultraviolet infringement, obviously reduces the effect of skin sunburn.In addition, rutin to ultraviolet ray and x-ray there is extremely strong absorption, as sun-screening agent, to ultraviolet absorptivity up to 98%.According to external, researcher detects effect of rutin to ultraviolet radiation with three kinds of different cell lines, finds that rutin has protection Skin Cell and avoids ultraviolet infringement.

4, freckle removing and whitening: zoopery confirms, rutin can rapid osmotic to skin bottom, the activity of restraint of tyrosinase, the generation of effective check melanin, reaches obvious skin whitening effect.Meanwhile, rutin can also be accelerated the microcirculation of skin, has experimental data to show, rutin has remarkable adjusting vasomotoricity, on skin, can obviously stimulate circulation, and makes the white wise man of skin tender.In addition, rutin can also protect collagen oxidized, can keep skin water profit vigor.Rutin and other vitamin composition use in conjunction, more can promote skin self-regeneration.

(3), Tea Polyphenols (EGCG), be from tealeaves extract a kind of chemical analysis.Account for 25 in tealeaves---35%.Tea Polyphenols comprises catechin, the compound general name of phenolic acid and depside, flavonols and Pigments.Its chemical constitution, with multiple activity hydroxies, has many health-care efficacies to human body.Fat-reducing, reducing blood lipid, hypotensive, hypoglycemic, strengthen immunity, antibiotic and sterilizing, anticancer, antiviral, beautifying face and moistering lotion, protect the liver, anti-oxidant, the function such as delay senility.

Chemical analysis: Tea Polyphenols main component is catechin.(C), L-Epicatechin gallate (EGC), Epigallo-catechin gallate (EGCG) (EGCG) etc.

Physiological function: 1, fat-reducing: (1), promotion fat oxidation and metabolism: Tea Polyphenols can promote the oxidation Decomposition of aliphatic acid, reduce the accumulation of fat at belly, can also suppress the activity of liver fat synzyme, thereby reduce the synthetic and Liver fatty deposition of fat, can also stop the absorption of fat at enteron aisle, promote fat to discharge from ight soil simultaneously.The obesity that reduces the absorption of carbohydrate to be converted into fat and to cause.

(2), suppress the activity of carbohydrase: Tea Polyphenols can suppress invertase, the sweet enzyme of glucose, α---diastatic activity, and the absorption that reduces carbohydrate is converted into fat and the obesity that causes.Scientific research confirmation, carbohydrate can form fat by enzyme and biological chemistry action in vivo.Therefore the activity that, Tea Polyphenols can suppress lipase plays antiobesity action.

(3), suppress the activity of lipase: Tea Polyphenols can suppress lipase, thereby reduces the accumulation of food digestion rate minimizing body fat.Tea Polyphenols also can directly act on the differentiation of adipocyte, and can induce mature cell to adjust and die.Further research, Tea Polyphenols can directly suppress gastric lipase and pancreatic lipase modulation of appetite.Researcher also finds that Tea Polyphenols suppresses the fat absorption in food, and acceleration fat ejects performance antiobesity action in body.

(4), regulate leptin secretion: leptin is a kind of polypeptide hormone of being secreted by adipocyte, and it enters blood, and circulate rear and hypothalamic leptin receptors bind, carry out the consumption of modulation of appetite and energy and control body weight by hypothalamus.Leptin can directly suppress the secretion of insulin, reduces Fatty synthesis, reduces depot fat.Domestic experiment confirmation, Tea Polyphenols has obvious antiobesity action to obese rat, and the IC of rat, fat have obvious reduction, prove that Tea Polyphenols has obvious fat-reducing effect.According to external, Germany scientist confirms by zoopery, and tea polyphenolic compounds can reduce mouse body fat content, thereby plays antiobesity action.Researcher thinks, Tea Polyphenols is to reach fat-reducing by reducing fat in the absorption of enteron aisle and strengthening fatty oxidation.Japan scientist studies discovery, and Tea Polyphenols can suppress neutral fat in blood effectively to be increased, and stops the absorption of fat in enteron aisle, thereby fat is excreted.In clinical trial, the fat content after the feed of picked-up Tea Polyphenols in blood reduces by 20%.Separately, report, thease can obviously lower visceral adipose in this research, and experimenter takes Tea Polyphenols for continuous 90 days, in the situation that not changing diet and body movement activity, and the slightly body weight of super severe one, in waistline and abdomen, fatty area all significantly reduces.Researcher explains, the effect that Tea Polyphenols can exciting human self-energy consumes, and the fat of abdominal viscera excites responsively especially to this, therefore, Tea Polyphenols can obviously dwindle overweight people's belly and waistline.

2, beautifying face and moistering lotion: young beautiful, beautiful skin is everyone dream, but due to environmental factor, solar radiation, the factor such as aging, people's skin will blackening chap, follows the string, and what have also can produce foxiness, and freckles etc. affect people's beauty.Scientific research confirmation, Tea Polyphenols can effectively play the effects of beautification and nourishing face such as protection skin, freckle removing and whitening, elimination acne.

(1), it is sun-proof: after skin is irradiated by ultraviolet ray, can distend the blood vessels, occur red and swollen, the symptoms such as bubble, long-term irradiation can cause epidermis position melanin pigmentation, promote skin aging, coarse, it is the key factor of skin aging, and ultraviolet ray is the main source that skin changes wound, can cause the interior biomolecule of body and hydrone homolysis and injured skin, studies have shown that, Tea Polyphenols can hinder irradiation and the removing ultraviolet induction free radical of shelves ultraviolet ray to skin, the normal function of protection melanocyte, the activity of check melanin cellular abnormality, thereby effectively protect skin.According to relevant, one of the U.S. studies confirm that, Tea Polyphenols has very strong anti-oxidation function, after the skin care item that contain Tea Polyphenols are spread upon on skin, even if irradiated the effect that also can play obvious control skin sunburn by strong sunlight.

University of Alabama of the U.S. is to the sun-proof research discovery of Tea Polyphenols, ultraviolet Diazolidinyl Urea in sunlight produces a large amount of oxides, make skin become coarse, follow the string, scientific research personnel found through experiments, the people who smears Tea Polyphenols reduces 1/3 than the peroxide chemical combination content of smearing in placebo people's skin, and skin is injured slighter, thereby proves that Tea Polyphenols has sun-proof function.Further research, takes Tea Polyphenols sun-proof result identical with the effect of smearing Tea Polyphenols skin care item.

(2), freckle removing and whitening: Tea Polyphenols can suppress the activity of junket ammonia enzyme and peroxidase, thereby reduces melanin and stop peroxidatic reaction of lipid, effectively reduces melanic generation, reaches the effect of freckle removing and whitening.Research thinks, the black and white of skin is relevant with melanic content, and melanin is the natural ultra-violet absorber of a class; in the time that ultraviolet ray is irradiated on skin; skin will, in " conservation of nature state ", stimulate wheat to draw pigment to activate the activity of tyrosinase by ultraviolet ray, protects Skin Cell.Tyrosinase reacts the material that the one generating is called " DOPA " with the tyrosine in blood, DOPA forms through tyrosine oxidation, discharges melanin, makes skin darkening, can cause the production of chloasma, freckle.Further research, in the time of the abnormal stimulation such as ultraviolet ray irradiation or age growth, the chain reaction that activity in vivo oxygen can cause MDA produces MDA, and MDA can with the protein amino formation lipofuscin that reacts, just accumulate in vivo and become " senile plaque expelling " (senile plaque), research shows, Tea Polyphenols energy restraint of tyrosinase activity, especially the ECG in polyphenol, EGCG is the strongest to the inhibitory action of tyrosinase, in addition, Tea Polyphenols is to active oxygen, lipid free radical is the scavenger of special efficacy, reduce the generation of MDA by removing lipid free radical, thereby stop peroxidating process.Tea Polyphenols is the effect that can effectively be suppressed spot and pigment and played freckle removing and whitening by two kinds of methods.In addition, melanic forming process is also an oxidizing process, and powerful antioxidant of Tea Polyphenols effect can reduce the intermediate of pigment, the generation of check melanin, and can directly act on melanin, pigment is faded, thereby play the effect of skin whitening.

(3), prevent and treat acne: modern medicine study is thought, acne and hormone secretion have much relations, the male promotion skin that increases that swashs secretion is secreted active increasing, the long-pending interior fat bolt that forms of hair follicle that gives of the stasis of blood, affect skin adipose gland secretion and discharge, intrafollicular bacillus acnes contains the lipase that can make skin decompose simultaneously, and esterase can decompose intrafollicular skin ester, produce more free fatty, this free fatty hair follicle stimulating causes inflammation and acne occurs.Research shows, the catechin in Tea Polyphenols, and the activity of adjustable hormone, suppresses sebum and produces, and alleviates or eliminate the generation of acne.Tea Polyphenols has inhibition and antiinflammatory action simultaneously, and therefore, Tea Polyphenols has effect of prevention and Acne treatment.

3, remove free radical, delay senility: Tea Polyphenols can effectively be removed too much free radical in human body, Cell protection membrane structure, reducing human aging.Experiment shows, the emulative and combined with radical of Tea Polyphenols energy, and the chain reaction of termination free radical, thus prevent and alleviate the damage of excessive free radicals to human body, reach the effect except disease and health.Because the structure of tea multienzyme is enriched phenolic hydroxy group, phenolic group structure has higher stability, therefore, Tea Polyphenols has obvious removing free radical and delaying senility function.

4, anti-oxidant: a large amount of experiments show, Tea Polyphenols has very strong antioxidation and physiologically active and removes effect of free radical, and it can stop the reaction of disconnected fat oxidation, removes organized enzyme, reaches oxidation resistant effect.It is reported, Japanese scholars research is existing, and Tea Polyphenols is a kind of strong polyphenoils, and the halmatogenesis of cell is had to very strong inhibitory action.

5, strengthen immunologic function: experiment showed, that Tea Polyphenols has multiple effect to body's immunity.It is mainly manifested in by lowering cell per-compound content or regulating immunity by removing the excessive free radical generating in immune response pathway; And Tea Polyphenols has the double action of endogenous antioxidant and exogenous antioxidant concurrently; therefore there is the resultant effect of mutual coordinative role; it has the Promote immunity of stimulation raising effect (as the decline of delaying human body thymus gland to the body of immunologic hypofunction; protection lymphocyte is impaired; promote the activity of thymocytes proliferation; stimulate antibody activity variation etc.), and normal body's immunity is had to certain mediation protective effect, epidemic prevention allergy.Aspect raising immunologic function, there iing very important effect.

6, defaecation: studies have shown that, Tea Polyphenols selectively acts on gut flora, to harmful bacteria inhibitory action, as suppressed staphylococcus, proteus, beneficial bacterium being had to activation, lactic acid coccus, Bacillus acidi lactici and Bifidobacterium etc., thus effectively promote health.In addition, Tea Polyphenols can also strengthen enteron aisle and shrink and wriggling function, accelerates gastric emptying, and harmful substance in body is excreted in time, reaches the object of defaecation.The mechanism of Tea Polyphenols defaecation is mainly contraction and the creeping effect that can increase large intestine.

(4), glutathione (Giutathione), be the active kyrine being extensively present in animal's liver, blood, yeast, wheat embryo etc.Being the tripeptide compound being formed by peptide bond condensation by glutamic acid, cysteine and glycine, is to have important physiological function, broad-spectrum bioactive peptide.Glutathione has two molecules, and the active sulfenyl oxidative condensation of reduced glutathione (GSH) is disulfide bond, obtains oxidized form of glutathione (GSSH), but only has reduced form Glutathione just to have physiologically active.Scientific research thinks, glutathione is anti-oxidant, remove free radical, removing toxic substances, liver protecting, enhancing immunity, radioresistance, Dealcoholic sobering-up, beauty treatment are sun-proof, nti-freckle, delay senility, the effect such as anticancer.

Physiological function: 1, remove free radical: glutathione contains active SH, the H that metabolism of human cell can be generated ₂o ₂be reduced into H ₂o removes free radical.Free radical meeting damaging cells film, promotes body aging, and brings out cancer and artery sclerosis.Glutathione has remarkable effect of scavenging radical, and to the hydrogen peroxide producing in body, the free radical that hydroperoxides and lipid oxide generate all has scavenging action.

2, anti-oxidant: glutathione passes through antioxidation, the function of energy Cell protection film and cell, delaying cell aging, prevents erythrocyte hemolysis and promotes ferrihemoglobin reduction.Glutathione as cell intensive amount maximum containing sulfenyl biological micromolecule, not only participate in the anti-oxidant reaction of cell, maintain body redox equilibrium, also participated in regulating hyperplasia, immune response and in nervous system, serving as the effect of nerve regulation and neurotransmitter.Therefore there is antioxidation.

3, removing toxic substances: glutathione has the detoxication of wide spectrum, to body toxic compounds, as acrylonitrile, fluoride, vehicle exhaust, carbon monoxide, heavy metal ion, organic solvent, carcinogen etc. are poisoning all certain detoxication, glutathione can excrete in conjunction with also promoting with it, also can be used for the treatment of above-mentioned substance nosotoxicosis.Thereby protection human body is not subject to the infringement of vehicle exhaust, PM2.5, heavy metal, carcinogenic substance, infectious disease, excessive alcohol and poisonous element.

4, liver protecting: liver is the abundantest organ of human body Glutathione peptide content, the critical function of liver is detoxication, in the time that the glutathione in liver is on the low side, can cause toxicant metabolism to decline, cannot discharge toxic substance in body and cause the injury of liver function.As chronic alcoholism patient, the glutathione content of its cell Mitochondria is too low, and the active oxygen producing in metabolic process cannot be neutralized by glutathione, thereby can cause the disease such as death and cirrhosis of cell.It is reported, glutathione can be protected liver cell, and reduced glutathione has anti peroxidation of lipid, protects hepatocellular effect, can protect the liver, the fat of dispelling, anti-oxidant and anti-hepatic fibrosis, and treatment fatty liver, the fat hepatitis that transaminase is increased is more applicable.

5, radioresistance: the leukopenia that glutathione causes radioactive ray, radiopharmaceutical and antineoplastic has good protective effect, can be used for the supplemental treatment of tumor radiotherapy, chemotherapy.

6, spot-eliminating beauty treatment: glutathione has effect of restraint of tyrosinase, thus make the melanin that causes skin freckle, chloasma to form be difficult to generate, reach the effect of skin whitening.Zoopery proves, glutathione effectively check melanin generates the activity of enzyme, and blocking-up melanin deposits at skin surface, make to be deposited on hypopigmentation or disappearance on skin, and Wheat Protein, improve the anti-oxidation function of skin, and make skin produce the effect of gloss, whitening.

7, sun-proof whitening: the impaired and Apoptosis of Skin Cell that glutathione energy antiultraviolet causes, contributes to the skin injury that prevents that ultraviolet ray from causing skin sunburn.Prevention cutaneum carcinoma.Thereby reach the effect of skin care whitening.

8, antiallergy: study and show, glutathione can be treated the unbalance allergy that causes of human body by acetylcholine, CHE, has anti-allergic effects.

(5), Cys (L-Cysteine), cysteine is a kind of aliphatic polarity a-amino acid containing sulfydryl; Also be protein composite coding amino acid, can be transformed by the methionine in human body (dl-methionine of needed by human), also can mutually transform with cysteine.Cysteine is to belong to nonessential amino acid, is that methionine and serine synthesize cysteine through cystathionie in animal body, has many physiological actions, can alleviate the degree of intoxication of Toxic or toxic medicament, and protection liver, also has protective action to radiation.Cysteine derivative N-acetyl-L-cysteine can be used for the scorching discharge difficulty that waits expectoration of a control gas official.In addition, cysteine also has beautifying face and moistering lotion, promotes hair growth, relieves the effect of alcohol, radioresistance, anti-inflammatory, antiallergy, the effect such as eliminate the phlegm.

Physiological function: 1, removing toxic substances: cysteine has obvolvent effect etc. in vivo, therefore far-ranging poisonous substance is had to significant detoxication as formaldehyde, acetaldehyde, chloroform, carbon tetrachloride, lead, cadmium, chloromethane mercury, lipid peroxidation, PCB, fugutoxin, alcohol etc.It can be combined cysteine with human toxicity, and the material that changes solubility into excretes with bile, performance gas defence, the effect of healing.Human lung is infected with after dust, and tissue discharges oxygen radical to be increased, and causes the further infringement of lungs and lipid peroxidation to increase, and cysteine can be blocked this process, and protection lung avoids further infringement.

2, anti-inflammatory antiallergy: supply cysteine can reduce the activity of coloured glaze base enzyme in the time occurring that inflammation, allergy reduce the coloured glaze base enzymes such as courage phosphatase, improves inflammation and allergic symptom.

3, radioresistance: cysteine has significant radiation resistance, can effectively prevent the injury with radiotherapy.

4, sun-proof whitening: cysteine has sun-proof, anti-ultraviolet function significantly; Cell protection film by sunburn, prevent aging and pigmentation; reduce melanin and generate, ultraviolet ray is the key factor that skin forms color spot, and lipid fuscin, lipid peroxide material are also one of reasons.Research discovery, cysteine can stop the activity that can bring out melanic precursor substance tyrosine, can also suppress to generate lipid peroxide simultaneously, prevents the effect of chloasma.According to another report, cysteine maintains the activity of important coloured glaze base enzyme in the keratin of skin protein generates, and supplementary coloured glaze base, to safeguard the eubolism of skin, the bottom melanin that regulates the undermost chromatophore of epidermis to generate is a kind of ideal natural skin-lightening cosmetic.In addition, it can also remove the melanin of skin itself, changes the character of skin itself, makes skin become natural whitening.

In addition.Cysteine also has protection liver, the effect such as eliminate the phlegm.

(6), ellagic acid (Ellagic acid) has another name called gallic acid, Ellagic acid, is the dimerization derivative of gallic acid, is a kind of polyphenol dilactone.Extensively be present in various mushy fruits, a kind of natural polyphenol compound of the plants such as nut, has multiple physiological active functions.Especially chemical substance induction canceration and other multiple cancerations are had to obvious inhibitory action.

Physiological function: 1, anti-oxidant: ellagic acid has catechol type phenolic hydroxyl group, and phenolic hydroxyl group can be used as hydrogen donor, and various active oxygen is had to scavenging action, can be by singlet oxygen ¹o2 is reduced into active lower triplet oxygen ³o2, the possibility of minimizing free-radical generating is also the effective scavengers of various free radicals simultaneously, generates by taking out H-H reaction the procephalon XOD that active lower benzene oxygen radical generates, ellagic acid has significant inhibitory action to it.Ellagic acid also has very strong inhibitory action to the lipid peroxy reaction being caused by adriamycin, and its antioxidation activity is 50 times of vitamin.

2, antibacterial, antiviral: ellagic acid has very strong inhibitory action to mutation bacterium, germ, can protect the surface of a wound to avoid bacterium and invade, protect from infection, suppress ulcer.Meanwhile, ellagic acid and some Ellagitannins show HIV, reverse transcriptase and the A cells of the medulloblastoma virus (AMN) of bird, the inhibition of beta cell archaeal dna polymerase.Someone shows mouse test, and oral Ellagitannins can effectively suppress HIV and herpesviral.

3, hemoglutination, ellagic acid has coagulation function, can shorten blood coagulation time, is a kind of effectively coagulant, has now been used for controlling the hemorrhage of animal, is used for clinically separated plasma.

4, nti-freckle, whitening: studies have shown that, tan in the effectively activity of restraint of tyrosinase of acid, blocking-up melanin generates, and has the effect of freckle removing and whitening.In addition, ellagic acid also can effectively be protected and avoid extraneous injury, and has antioxidation.In addition, ellagic acid also has hypotensive, sedation.

5, sun-proof whitening: studies have found that, ellagic acid has sun-proof and effect restraint of tyrosinase surplus, thus make the pigment that causes skin freckle, chloasma to form be difficult to generate, reach the effect of skin whitening.Zoopery proves, the contrast test by ultraviolet ray to skin exposure three phases can effectively suppress Skin pigmentation.Detect the brightness (L value) of exposure skin with colour difference meter, verification result demonstration, the L value of control animals is low, and ellagic acid picked-up animal groups L value is obviously higher, proves that pigment deposition is subject to obvious inhibition.According to another report, ellagic acid has very strong antioxidation, can make Skin Cell avoid the infringement that ultraviolet ray is irradiated, and trophocyte, reduces skin senescence, and sun-proof result is stronger than red wine and Tea Polyphenols, can also effectively slow down skin aging, prevents that wrinkle from occurring.

(7), ceramide (Ceramide), have another name called N-fatty acyl group sphingosine; It is a kind of lipolysaccharide compound being present in natural plants.Ceramide is to have fatty acid structure in ammonia alcohol, is both two kinds of dissimilar glycolipid matter that combine with sugar and fat respectively, and this aliphatic acid of amino and certain is wherein connected with amido bond form, and 1-position hydroxyl combines with the form of glycosidic linkage with certain sugar.Due to connected Fatty acid and sugar base difference, therefore there is diversified structure.Ceramide, is also present in breast, blood, spinal cord and nerve fiber at human body except skin.Have efficient moisture-keeping efficacy, energy active cell ability, promotes cell metabolism, impels the regular regeneration of keratoprotein, moisturizing, sun-proof whitening, alleviates the effects such as allergic dermatitis.

Physiological function: 1, moisturizing is brightened: ceramide has moisturizing, brightens, alleviates the effect of allergic dermatitis skin, skin is that protection body is avoided outside infringement (comprising physics, chemistry, biology) and prevents that the loss of body fluids such as moisture are to safeguard the necessary barrier of life.Skin is made up of skin corium, basalis, table matter layer and cuticula from the inside to the outside.Ceramide is accumulated in cuticula substantially, is the main component (approximately 50%) of lipid between horn cell, in performance stratum corneum barrier function, plays an important role, and suppresses moisture evaporation or freezes.Aging with skin with age, lipid content between horn cell can obviously reduce, main component ceramide wherein also declines thereupon, skin is easily occurred dry, wrinkle, the phenomenon such as coarse, meanwhile, if ceramide content is not enough in cuticula, can become the one of the main reasons of particularity dermatitis.Therefore, often supplement ceramide, can recover the normal configuration of skin, thereby recover the original barrier function that prevents moisture evaporation and extraneous harmful substance immersion skin of skin, improve the resistance to compliance of skin.Experiment confirmation, oral ceramide can improve whole skin water containing property, increases the moisture-holding capacity of skin, improves skin elasticity simultaneously, reduces the skin makeup effects such as wrinkle.With as cosmetics, external application has same effect.

2, sun-proof nti-freckle: along with social economy's fast development, people out of doors the activity time increase, due to the pollution of environment, atmospheric ozone layer attenuation, ultraviolet ray is anxious to be increased, in the summer that particularly The sun is shining fiercely, ultraviolet irradiation meeting causes serious damage to skin.Experiment confirmation, ceramide has the moistening effect that keeps the skin wet significantly, and moisture is the important component part of human body, and it can protect skin not tanned severely by ultraviolet ray.Further research, carries out in vitro test confirmation with B16 melanocyte, and ceramide has check melanin generation, can make the effect of skin brightening.

In addition, neurolemma lipid is also the composition of cell membrane, has the physiological action such as cell proliferation, differentiation.

(8), lycopene (Lycopene), lycopene belongs to carotenoid, tetraterpenes compound is made up of 11 conjugation and two non-conjugated carbon two strandss.Mainly be present in the plants such as tomato, watermelon, guava, owing to extracting from tomato the earliest, the ancient lycopene that claims.Pharmacological research is found, tomato red have than other carotenoid and has better biologically active, anti-oxidant, removes peroxy radical, prevention and cure of cardiovascular disease, anticancer, uvioresistant, the effects such as wrinkle sun-proof, whitening, open and flat, delay skin aging, activating immune cell.

Physiological function: 1, oxidation and removing free radicals: lycopene be in the carotenoid found so far antioxidation the most by force, the most effective singlet oxygen quencher, its effect is 2 times of beta carotene, 100 times of α-Vitamin E.There is quenching singlet oxygen and catch peroxylradicals, by physics and chemistry mode quenching singlet oxygen, the reaction of prevention lipid peroxidation, protection biomembrane is avoided the damage of free radical.Can think that accordingly lycopene can stop endogenous oxidant to cause spontaneous gene mutation.It is reported, solar radiation, the ambient influnences such as airborne harmful substance or stress and disease all can make human body form more free radical, and these free radicals can damage the DNA in skin, thereby accelerate skin aging.Research discovery, lycopene has the well anti-oxidant effect with removing free radical to skin.

2, sun-proof, ultra-violet radiation resisting: skin head is irradiated in ultraviolet ray ought be wherein, can cause a series of chain reactions such as dry skin, coarse, wrinkling, blackspot, aging, and research finds, what ultraviolet ray irradiation was destroyed at first is the lycopene in skin.Absorb appropriate lycopene and store in skin, can prevent and treat ultraviolet Irradiation on Skin injury, and be stored in lycopene in skin, can absorb the ultraviolet ray of sunlight or by ultraviolet ray " reflection " or " refraction ", protect Skin Cell.According to another report, lycopene can stop ultraviolet absorption, can also obstruct the destruction of DNA and colloid, can discharge the free radical that damages cell when ultraviolet ray occurs, and repairs the skin after sunburn.

3, whitening, inhibition pigmented spots generate: lycopene is powerful antioxidant, can prevent the synthetic activity and the hyaluronidase activity that suppresses to bring out inflammation that promotes enzyme tyrosinase of melanin, irradiate thereby can alleviate by ultraviolet ray the pigmented spots that cause, the symptoms such as blackspot, thereby there is whitening function.

4, delay skin aging: research is found; lycopene has very strong anti-oxidant, radiation-resistant biologically active; can effectively remove free radical; prevent ultraviolet ray and the infringement of various external radiations to Skin Cell; promote growth and the regeneration of Skin Cell; protection skin eubolism, effectively prevents and treats color spot, wrinkle, prevention skin senescence.

5, flatten wrinkle and reduce wrinkle: eat the vegetables such as tomato more, can make people seem young, wrinkle is few.An experiment shows, the lycopene containing in tomato contributes to effect of open and flat new wrinkle, makes skin delicacy smooth.Research also finds, it is young that the high people of oxidation preventive content in skin looks, accepting in testing staff of 40-50 year, people's wrinkle that in skin, lycopene concentration is high is few.

In addition, lycopene also have the immunity of raising, anticancer, prevent the effect such as angiocardiopathy, vision protection.

(9), (Vit c), has another name called ascorbic acid to vitamin C.It is the natural materials being extensively present in fruits and vegetables.Vitamin C is a kind of simple six carbon compounds, and occurring in nature has two kinds of existence forms, and reduced form ascorbic acid and oxidized form hydroascorbic acid, both have physiologically active, all can be utilized by body.Vitamin C is white crystalline powder, with obvious tart flavour, soluble in water, should not under high temperature and alkali condition, process.

Physiological function: 1, participate in biosynthesis, vitamin C in vivo in digestion process enzyme and the cofactors as substrate participate in multiple important biosynthetic process, comprise collagen, the synthetic and tyrosine metabolism of other nerve-mediator of carnitine and peptide hormone etc.Some enzyme require vitamin C could keep the activity of height.

2, reduction: vitamin C has the reduction of height, can make the ferric ion that is difficult to absorb be reduced into ferrous ion, promotes the absorption of enteron aisle to iron.Vitamin C can also increase the activity of some iron enzyme, thereby is conducive to the utilization of iron.Therefore hypoferric anemia except mending ferrous preparation, also must be taken vitamin C effect just more obvious simultaneously.Vitamin C has anti-oxidation function, can also reduce superoxides, hydroxyl, hypochlorous acid and other activating oxide and other antioxidant for clearing free radical, blocking-up lipid peroxidation.

3, breast augmentation: vitamin C is the main component that maintains udder health, has important effect to maintaining connective tissue eubolism.Vitamin C, to keeping the young vigor of the property features such as breast, impels smooth muscle cells collagen synthesis albumen, and the Maintenance Of Skin Health and breast augmentation have important effect.

4, improve immunity, anti-flu: vitamin C can promote prostate and lymph liquid secretion, make body produce interferon and antitoxin, thereby play immunity and antivirus action, improve control ability to body tissue, contribute to syntheticly can regulate lymphocytic prostaglandin.US Experts research shows, every day, 1 gram of left and right vitamin C can make flu decline 45%, and the course of disease shortens 60%.Vitamin C can be linked up respiratory apparatus and be stimulated circulation, and preventing respiratory infects, and strengthens the oxidation of body requirement, reduces flu and occurs.Vitamin C, except above-mentioned functions, also has the skin health of maintaining, the anti-ageing several functions of waiting for a long time.

5, skin whitening: vitamin C is to prevent that freckle from forming most important vitamin, the vigor that it can check melanin, has the effect that keeps skin-whitening.Vitamin C and derivative thereof can play reduction to melanin intermediate, thereby stop tyrosine and DOPA to change melanin in each branch of oxidation chain reaction.Vitamin c has the effect of prevention pigment deposition and bleaching skin.According to another research, vitamin C energy check melanin generates, to day sunburn, blackspot etc. there is the effect of reduction whitening, make the moist and elasticity of skin.

6, anti-ageing: vitamin C can catch the free radical outside cell membrane, protection body is avoided infringement and the blood vessel endothelium system integrity of free radical.Vitamin C is antioxidant, can prevent subcutaneous fat oxidation, strengthens the vigor of skin surface and dermal cell, avoids skin early ageing.

Thereby enhancing body immunity, makes human body avoid viral infringement.In flu patient's leucocyte, Vitamin C content obviously declines.

(10), vitamin E (VitE) has another name called Vitamin E.Be E, β, γ and δ Vitamin E, 8 kinds of α, β, γ and δ triolefin Vitamin Es are called vitamin E with family system.Wherein the biologically active of E mono-Vitamin E is the strongest.Vitamin E belongs to liposoluble vitamin, water insoluble, to oxygen sensitivity, is easy to Oxidative demage, especially at sunlight, can accelerate its oxidation under heat, alkali condition, comparatively stable under acid oxygen free condition.

Physiological function: 1, anti-oxidant: vitamin E is a kind of very strong antioxidant, avoids the infringement of free radical at Cell protection film.Brain cell contains a large amount of unrighted acids, and vitamin E can prevent that unrighted acid is oxidized, thereby the eubolism of protection brain cell is with movable, prevents brain oxidation decline.Vitamin E also can neuroprotective system, and skeletal muscle, retina are avoided oxidative damage, and the normal development of nerve system of human body and retina need sufficient vitamin E.Nervous system is with a large amount of free-radical generating in generation neurotransmitter process, and therefore vitamin E is essential preventing that mitochondria and neural tactile prominent film from avoiding aspect free radical damage.

2, promote breast enlargement: vitamin E can impel development of ovary maturation, increase gonad cell, regulate estrogen secretion, thereby promote lactiferous ducts to increase, contribute to breast development to impel breast enlargement.In addition vitamin E can be prevented and treated and in utero put ring excessive menstruation, hypogalactia after delivery, antiabortive etc.

3, delay skin aging: natural VE is described as " preserve the youth " vitamin.Due to unique antioxidation, can distend the blood vessels, stimulate circulation, enliven skin cell metabolism, skin care, increases skin elasticity and gloss, and offseting depigmentation calmness, chloasma, senile plaque expelling, striae of pregnancy and shallow table scar also has good effect.

4, delaying wrinkle produces: wrinkle of skin is often due to subcutaneous fat loss, and the fracture of elastomer and the degraded of collagen tissue produce, and vitamin E can stop the formation of lipid peroxide, protective tissue contact; Make skin keep elasticity.Vitamin E is treated the effect of freckle in addition.

5, uvioresistant: research shows; the antioxidant system of skin can reduce the damage of ultraviolet radiation to skin; to there is protection skin and there is the vitamin E in skin; reducing ultraviolet radiation injury skin plays an important role; taking in vitamin E can be accumulated in skin; and the vitamin E of skin can absorb some visible ray ultraviolet rays, or by ultraviolet ray " reflection " or " refraction ".Vitamin E has very strong anti-oxidation function on the other hand, reduces free-radical contents, to maintain the immune system activity of cell.According to another report, ultraviolet ray is irradiated and can be produced a large amount of high mars free radicals, and vitamin E, as the powerful scavenger of free radical, can be repaired the epidermis injury that radiation produces.According to external, Dusseldorf ,Germany Scientific Research in University group study confirms, vitamin E can make human body possess stronger anti-uv-ray, be vitamin E it can strengthen the function of other antiultraviolet material, and strengthen skin and better resist the ability of radiation, this is medically to prove first that this may.Experiment showed, in uvioresistant and use, do not take vitamin E lower by 29% than the people who takes vitamin E.Therefore, vitamin E can strengthen the anti-ultraviolet ability of human body, prevents the generation of sunburn.In addition, vitamin E can also reduce the chloasma that sunburn causes.

Evil skin plays an important role, and taking in vitamin E can be accumulated in skin, and the vitamin E of skin can absorb some visible ray ultraviolet rays, or by ultraviolet ray " reflection " or " refraction ".Vitamin E has very strong anti-oxidation function on the other hand, reduces free-radical contents, to maintain the immune system activity of cell.According to another report, ultraviolet ray is irradiated and can be produced a large amount of high mars free radicals, and vitamin E, as the powerful scavenger of free radical, can be repaired the epidermis injury that radiation produces.According to external, Dusseldorf ,Germany Scientific Research in University group study confirms, vitamin E can make human body possess stronger anti-uv-ray, be vitamin E it can strengthen the function of other antiultraviolet material, and strengthen skin and better resist the ability of radiation, this is medically to prove first that this may.Experiment showed, in uvioresistant and use, do not take vitamin E lower by 29% than the people who takes vitamin E.Therefore, vitamin E can strengthen the anti-ultraviolet ability of human body, prevents the generation of sunburn.In addition, vitamin E can also reduce the chloasma that sunburn causes.

6, prevent and treat chloasma and pigmented spots: pigmented spots medical science is called " senile pigmented spots ".It is a chemical substance of being lipofuscin pigment, is also the oxide of unrighted acid, i.e. lipofuscin.Vitamin E is the most important antioxidant of body, can prevent the peroxidating of unrighted acid in body, and has the function of removing free radical, and to reduce the generation of lipofuscin, therefore, vitamin E can suppress the generation of pigmented spots.

According to external, megavitamin E continues 3～9 months, can make chloasma faciei and pigmented spots reduce, and even disappears, and efficiently reaches 70%～90%, and its mechanism is mainly to suppress lipid oxide to generate, and reverses skin senescence.According to another report, vitamin E has the effect for the treatment of freckle.

7, antitumor: vitamin E has inhibitory action to exceeding 90% malignant tumour in all types of tumours of the mankind, its medium effective concentration is 5-10mg/L, under this concentration, can significantly suppress breast cancer, the cancer of the uterus, colon cancer, the growth of the tissue tumors such as lymph cancer, and on normal auxocyte without impact, the real danger of contrast also shows, uses separately vitamin E, the Risk Reduction 20% that homovitamin C can make breast cancer occur.Separately have report, vitamin E can stop the growth of cancer cell initial period and the breeding out of control of cancer cell.Vitamin E, as a kind of antioxidant, can be adsorbed onto the surface of damaged cell, and excites its " suicide ".It also can strengthen body immunity simultaneously, prevents that cancer cell from immersing in blood vessel, obtains nutrition thereby block tumour.

In addition, vitamin E can also improve skin of head blood circulation, have anti-loss, the effect of white hair, skin pore can be secreted and to contain vitamin E sebum, keeps the health of hair and beautiful.

In sum, this product have anti-oxidant, remove the effects such as free radical, replenishing water and preserving moisture, sun-proof, ultraviolet radiation resisting, freckle removing and whitening, open and flat wrinkle of skin, delay skin aging.

Six, manufacture craft:

1, allotment mixes: first the raw material in formula is mixed by physical characteristic.

2, stir: mixed raw material is sent into mixer, stir.

3, compressing tablet: by the raw material stirring, send into tablet press machine and be pressed into tablet.

4, test package: by the tablet being pressed into, be up to the standards, packaging becomes formal product.

Allotment mixed processes is the process that the raw material in formula is mixed by its physical characteristic.Agitating procedure is the process that mixed raw material is stirred.Sheeting process is the process of the raw material stirring being sent into tablet press machine and is pressed into tablet.Test package operation is by the tablet of compacting, is up to the standards, and packaging becomes formal product.

Seven, quality index:

1, a kind of jade index:

2, instructions of taking: every day three times, each 0.8～1.2 gram

3, be suitable for crowd: adapt to each age group outdoor study personnel and the men and women personage that likes to be beautiful.

Eight, tool present embodiment:

Embodiment: getting 0.5 kilogram of 30 kilograms of black wolfberry fruit extract, 2.5 kilograms of rutins, Tea Polyphenols double centner, 12.5 kilograms of glutathione, 50 kilograms of Cys, 50 kilograms of ellagic acids, 40 kilograms of ceramides, 0.16 kilogram of lycopene, 30 kilograms of vitamin Cs, vitamin E is that raw material mixes, stir, send into tablet press machine, raw material is pressed into tablet, be up to the standards, packaging becomes formal product.

Claims (1)

1. the sun-proof whitening sheet of black matrimony vine manufacture craft, it is characterized by: 0.5 kilogram of 30 kilograms of black wolfberry fruit extract, 2.5 kilograms of rutins, Tea Polyphenols double centner, 12.5 kilograms of glutathione, 50 kilograms of Cys, 50 kilograms of ellagic acids, 40 kilograms of ceramides, 0.16 kilogram of lycopene, 30 kilograms of vitamin Cs, vitamin E are raw material, through above raw material is mixed by physical characteristic, stir, send into tablet press machine, raw material is pressed into tablet, be up to the standards, packaging becomes formal product.