CN102176941A - 吸入器 - Google Patents
吸入器 Download PDFInfo
- Publication number
- CN102176941A CN102176941A CN2009801402076A CN200980140207A CN102176941A CN 102176941 A CN102176941 A CN 102176941A CN 2009801402076 A CN2009801402076 A CN 2009801402076A CN 200980140207 A CN200980140207 A CN 200980140207A CN 102176941 A CN102176941 A CN 102176941A
- Authority
- CN
- China
- Prior art keywords
- inhaler
- cyclone chamber
- inlet
- vesicle
- air
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M15/00—Inhalators
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
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- A—HUMAN NECESSITIES
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- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
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- A61M15/0021—Mouthpieces therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0818476.4A GB0818476D0 (en) | 2008-10-09 | 2008-10-09 | Inhaler |
| GB0818476.4 | 2008-10-09 | ||
| PCT/EP2009/063038 WO2010040779A2 (en) | 2008-10-09 | 2009-10-07 | Inhaler |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102176941A true CN102176941A (zh) | 2011-09-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801402076A Pending CN102176941A (zh) | 2008-10-09 | 2009-10-07 | 吸入器 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20110192397A1 (enExample) |
| EP (1) | EP2331178A2 (enExample) |
| JP (1) | JP2012509690A (enExample) |
| KR (1) | KR20110083597A (enExample) |
| CN (1) | CN102176941A (enExample) |
| AR (1) | AR073819A1 (enExample) |
| AU (1) | AU2009301148A1 (enExample) |
| BR (1) | BRPI0920428A2 (enExample) |
| CA (1) | CA2738784A1 (enExample) |
| GB (1) | GB0818476D0 (enExample) |
| IL (1) | IL212211A0 (enExample) |
| MX (1) | MX2011003675A (enExample) |
| RU (1) | RU2011118464A (enExample) |
| TW (1) | TW201032845A (enExample) |
| WO (1) | WO2010040779A2 (enExample) |
| ZA (1) | ZA201101856B (enExample) |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989007464A1 (en) * | 1988-02-22 | 1989-08-24 | Harris Pharmaceuticals Ltd | Dispensers for powdered medication |
| GB2248400A (en) * | 1990-10-02 | 1992-04-08 | Atomic Energy Authority Uk | Powder inhaler |
| CN1160358A (zh) * | 1994-09-21 | 1997-09-24 | 吸入治疗系统 | 用于喷洒干的粉末药物的方法和装置 |
| CN1209755A (zh) * | 1996-01-29 | 1999-03-03 | 厄恩斯特·赫尔林 | 用于粉末吸入器的胶囊开启装置 |
| CN1867369A (zh) * | 2003-10-17 | 2006-11-22 | 维克多瑞有限公司 | 吸入器 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI84698C (fi) | 1989-06-16 | 1992-01-10 | Huhtamaeki Oy | Anordning foer finfoerdelning av agglomerat av en enkeldos av ett laekemedelpreparat i pulverform. |
| AT393979B (de) | 1989-11-07 | 1992-01-10 | Kufstein Schablonentech Gmbh | Vorrichtung zum bearbeiten von hohlzylindern mittels eines lasers |
| DE4208880A1 (de) * | 1992-03-19 | 1993-09-23 | Boehringer Ingelheim Kg | Separator fuer pulverinhalatoren |
| US5785049A (en) * | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| CN1213974A (zh) * | 1996-01-03 | 1999-04-14 | 葛兰素集团有限公司 | 吸入器具 |
| US6470884B2 (en) * | 1996-01-29 | 2002-10-29 | Aventis Pharma Limited | Capsule opening arrangement for use in a powder inhaler |
| GB9626263D0 (en) * | 1996-12-18 | 1997-02-05 | Innovata Biomed Ltd | Powder inhaler |
| JP2000217920A (ja) * | 1999-01-28 | 2000-08-08 | Unisia Jecs Corp | 吸入式投薬器 |
| GB2353222B (en) | 1999-06-23 | 2001-09-19 | Cambridge Consultants | Inhalers |
| US6427688B1 (en) * | 2000-02-01 | 2002-08-06 | Dura Pharmaceuticals, Icn. | Dry powder inhaler |
| EP1129705A1 (en) * | 2000-02-17 | 2001-09-05 | Rijksuniversiteit te Groningen | Powder formulation for inhalation |
| PE20020066A1 (es) * | 2000-06-23 | 2002-02-23 | Norton Healthcare Ltd | Deposito de dosis medidas previamente para inhalador de polvo seco accionado por la respiracion |
| KR20040023597A (ko) * | 2001-05-10 | 2004-03-18 | 벡투라 딜리버리 디바이시스 리미티드 | 흡입기들 |
| KR20050085237A (ko) * | 2002-12-02 | 2005-08-29 | 더 거버너스 오브 더 유니버시티 오브 알버타 | 흡입용 분말로 분쇄하기 위한 장치 및 방법 |
| US20060147389A1 (en) * | 2004-04-14 | 2006-07-06 | Vectura Ltd. | Devices and pharmaceutical compositions for enhancing dosing efficiency |
| EP1488819A1 (en) * | 2003-06-16 | 2004-12-22 | Rijksuniversiteit te Groningen | Dry powder inhaler and method for pulmonary inhalation of dry powder |
| GB0410712D0 (en) * | 2004-05-13 | 2004-06-16 | Novartis Ag | Organic compounds |
| EP2534957B1 (en) * | 2007-12-14 | 2015-05-27 | AeroDesigns, Inc | Delivering aerosolizable products |
| HUE027246T2 (en) * | 2008-01-24 | 2016-10-28 | Vectura Delivery Devices Ltd | inhaler |
-
2008
- 2008-10-09 GB GBGB0818476.4A patent/GB0818476D0/en not_active Ceased
-
2009
- 2009-10-07 BR BRPI0920428A patent/BRPI0920428A2/pt not_active IP Right Cessation
- 2009-10-07 KR KR1020117005574A patent/KR20110083597A/ko not_active Withdrawn
- 2009-10-07 AU AU2009301148A patent/AU2009301148A1/en not_active Abandoned
- 2009-10-07 CN CN2009801402076A patent/CN102176941A/zh active Pending
- 2009-10-07 CA CA2738784A patent/CA2738784A1/en not_active Abandoned
- 2009-10-07 US US13/122,781 patent/US20110192397A1/en not_active Abandoned
- 2009-10-07 JP JP2011530481A patent/JP2012509690A/ja active Pending
- 2009-10-07 EP EP09736184A patent/EP2331178A2/en not_active Withdrawn
- 2009-10-07 MX MX2011003675A patent/MX2011003675A/es unknown
- 2009-10-07 RU RU2011118464/14A patent/RU2011118464A/ru not_active Application Discontinuation
- 2009-10-07 WO PCT/EP2009/063038 patent/WO2010040779A2/en not_active Ceased
- 2009-10-08 TW TW098134055A patent/TW201032845A/zh unknown
- 2009-10-09 AR ARP090103913A patent/AR073819A1/es not_active Application Discontinuation
-
2011
- 2011-03-10 ZA ZA2011/01856A patent/ZA201101856B/en unknown
- 2011-04-07 IL IL212211A patent/IL212211A0/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989007464A1 (en) * | 1988-02-22 | 1989-08-24 | Harris Pharmaceuticals Ltd | Dispensers for powdered medication |
| GB2248400A (en) * | 1990-10-02 | 1992-04-08 | Atomic Energy Authority Uk | Powder inhaler |
| CN1160358A (zh) * | 1994-09-21 | 1997-09-24 | 吸入治疗系统 | 用于喷洒干的粉末药物的方法和装置 |
| CN1209755A (zh) * | 1996-01-29 | 1999-03-03 | 厄恩斯特·赫尔林 | 用于粉末吸入器的胶囊开启装置 |
| CN1867369A (zh) * | 2003-10-17 | 2006-11-22 | 维克多瑞有限公司 | 吸入器 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11471623B2 (en) | 2012-02-21 | 2022-10-18 | Respira Therapeutics, Inc. | Powder dispersion methods and devices |
| US10682476B2 (en) | 2012-02-21 | 2020-06-16 | Respira Therapeutics, Inc. | Powder inhaler, system and methods |
| CN104582772A (zh) * | 2012-07-05 | 2015-04-29 | 葛兰素集团有限公司 | 吸入器装置 |
| CN104582772B (zh) * | 2012-07-05 | 2018-02-09 | 葛兰素集团有限公司 | 吸入器装置 |
| US10638792B2 (en) | 2013-03-15 | 2020-05-05 | Juul Labs, Inc. | Securely attaching cartridges for vaporizer devices |
| US10993471B2 (en) | 2013-12-23 | 2021-05-04 | Juul Labs, Inc. | Vaporization device systems and methods |
| US10986867B2 (en) | 2013-12-23 | 2021-04-27 | Juul Labs, Inc. | Vaporization device systems and methods |
| US11992044B2 (en) | 2013-12-23 | 2024-05-28 | Juul Labs, Inc. | Vaporization device systems and methods |
| US11752283B2 (en) | 2013-12-23 | 2023-09-12 | Juul Labs, Inc. | Vaporization device systems and methods |
| US10667560B2 (en) | 2013-12-23 | 2020-06-02 | Juul Labs, Inc. | Vaporizer apparatus |
| CN106028846A (zh) * | 2013-12-23 | 2016-10-12 | Pax实验室公司 | 蒸发装置系统和方法 |
| US10701975B2 (en) | 2013-12-23 | 2020-07-07 | Juul Labs, Inc. | Vaporization device systems and methods |
| US10912331B2 (en) | 2013-12-23 | 2021-02-09 | Juul Labs, Inc. | Vaporization device systems and methods |
| US11452177B2 (en) | 2014-02-06 | 2022-09-20 | Juul Labs, Inc. | Vaporization device systems and methods |
| US10709173B2 (en) | 2014-02-06 | 2020-07-14 | Juul Labs, Inc. | Vaporizer apparatus |
| US11019685B2 (en) | 2014-02-06 | 2021-05-25 | Juul Labs, Inc. | Vaporization device systems and methods |
| CN106794325B (zh) * | 2014-02-21 | 2020-06-30 | 瑞必治公司 | 粉末吸入器、系统和方法 |
| CN106794325A (zh) * | 2014-02-21 | 2017-05-31 | 瑞必治公司 | 粉末吸入器、系统和方法 |
| CN107427650A (zh) * | 2015-01-14 | 2017-12-01 | 瑞必治公司 | 粉末分散方法和装置 |
| US12128180B2 (en) | 2015-07-10 | 2024-10-29 | Juul Labs, Inc. | Wickless vaporizing devices and methods |
| US10865001B2 (en) | 2016-02-11 | 2020-12-15 | Juul Labs, Inc. | Fillable vaporizer cartridge and method of filling |
| US11751605B2 (en) | 2016-02-11 | 2023-09-12 | Juul Labs, Inc. | Securely attaching cartridges for vaporizer devices |
| US10912333B2 (en) | 2016-02-25 | 2021-02-09 | Juul Labs, Inc. | Vaporization device control systems and methods |
| US12063973B2 (en) | 2016-02-25 | 2024-08-20 | Juul Labs, Inc. | Vaporization device control systems and methods |
| CN110799230A (zh) * | 2017-06-27 | 2020-02-14 | 韩国联合制药株式会社 | 干燥粉末吸入器 |
| CN111182934A (zh) * | 2017-08-30 | 2020-05-19 | 因多西斯有限公司 | 多剂量药物输送装置 |
| CN110812635A (zh) * | 2019-11-18 | 2020-02-21 | 德必来福有限公司 | 一种吸入粉雾剂给药装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012509690A (ja) | 2012-04-26 |
| CA2738784A1 (en) | 2010-04-15 |
| GB0818476D0 (en) | 2008-11-12 |
| AR073819A1 (es) | 2010-12-01 |
| ZA201101856B (en) | 2014-08-27 |
| US20110192397A1 (en) | 2011-08-11 |
| TW201032845A (en) | 2010-09-16 |
| RU2011118464A (ru) | 2012-11-20 |
| WO2010040779A3 (en) | 2010-07-01 |
| EP2331178A2 (en) | 2011-06-15 |
| WO2010040779A2 (en) | 2010-04-15 |
| MX2011003675A (es) | 2011-05-02 |
| AU2009301148A1 (en) | 2010-04-15 |
| KR20110083597A (ko) | 2011-07-20 |
| IL212211A0 (en) | 2011-06-30 |
| BRPI0920428A2 (pt) | 2019-09-24 |
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