CN102166164A - 一种化妆品组合物 - Google Patents
一种化妆品组合物 Download PDFInfo
- Publication number
- CN102166164A CN102166164A CN 201110087940 CN201110087940A CN102166164A CN 102166164 A CN102166164 A CN 102166164A CN 201110087940 CN201110087940 CN 201110087940 CN 201110087940 A CN201110087940 A CN 201110087940A CN 102166164 A CN102166164 A CN 102166164A
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- Prior art keywords
- acid
- oil
- peg
- polyoxyethylene ether
- cosmetic composition
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Abstract
一种化妆品组合物，具体涉及一种含有磷脂氢谷胱甘肽过氧化物酶及还原型谷胱甘肽的化妆品组合物。其特征是由0.01％-1％的磷脂氢谷胱甘肽过氧化物酶、0.1％-5％还原型谷胱甘肽、5％-20％润肤剂、70％-90％极性溶剂、0.1％-2.5％增稠剂及0.1％-5％表面活性剂组成。该化妆品组合物采用了磷脂氢谷胱甘肽过氧化物酶及还原型谷胱甘肽复配物制备一种化妆品，显著提高了还原型谷胱甘肽抗氧化清除自由基能力。
Description
技术领域
本发明属于化妆品技术领域，具体涉及一种含有磷脂氢谷胱甘肽过氧化物酶及还原型谷胱甘肽的化妆品组合物。
背景技术
活性氧(Reactive Oxygen Species，ROS)是一种活性很强的含氧活性物质，ROS主要包含氧自由基(羟基自由基，超氧阴离子自由基)和分子物质(过氧化氢，脂类过氧化物)[1]。生物体内主要的活性氧自由基有单线态氧(102)；过氧化氢(H2O2)、超氧阴离子(O2·-)、羟自由基(OH·)和脂质过氧化物(ROOH和ROO·)及烷自由基(R·)等，这些活性氧自由基都是一些高活性基团，很容易得失电子。它们的化学性质十分活泼，氧化能力很强。活性氧对细胞的危害主要表现在以下三个方面：(1)引起不饱和脂肪酸，尤其是生物膜上具有重要生理意义的脂质的过氧化，脂质过氧化可以直接破坏细胞膜，严重时可以造成细胞坏死与凋亡；(2)活性氧可以攻击DNA，进而会造成DNA碱基变性，使生物变异、代谢紊乱，并且有致癌的可能；(3)引起蛋白质活性部位氨基酸以及其他部位的氨基酸残基，如Cys、Tyr、His和Met等氨基酸的氧化、肽键断裂等，进而致使蛋白质高级结构发生变化，最终造成蛋白质变性和失活。活性氧成为加速人体衰老的主要影响因素，当皮肤直接暴露于阳光、宇宙射线、空气及物理化学性污染物中时，就会是皮肤产生一种活性氧自由基，加速皮肤老化。
谷胱甘肽(Glutathione，GSH)属于含有巯基的小分子肽，谷胱甘肽是由谷氨酸半胱氨酸和甘氨酸通过肽键缩合而成的三肽化合物，是一种用途广泛的活性短肽。谷胱甘肽的结构中含有一个活泼的巯基-SH，易被氧化脱氧，这一特异结构使其成为体内主要的自由基清除剂。机体内新陈代谢产生的许多自由基会损伤细胞膜，侵袭生命大分子，促进机体衰老，并诱发肿瘤或动脉粥样硬化的产生。谷胱甘肽可以清除自由基，起到强有力的保护作用。例如当细胞内生成少量H2O2时，谷胱甘肽在谷胱甘肽过氧化物酶的作用下，把H2O2还原成H2O，其自身被氧化为GSSG，GSSG由存在于肝脏和红细胞中的谷胱甘肽还原酶催作用下，接受还原成谷胱甘肽，从而使体内自由基的清除反应能够持续进行。
磷脂氢谷胱甘肽过氧化物酶(phospholipid hydroperoxide glutathione peroxidase，PHGPx)是一类重要的抗氧化酶，它能够直接还原脂类过氧化物，在保护生物膜免受过氧化损伤方面发挥了关键作用。PHGPx的特异性相当广泛，它对所有的磷脂氢过氧化物都有活性，而且对脂肪酸过氧化物、叔丁基氢过氧化物、异丙基苯过氧化物、胸腺嘧啶过氧化物、胆固醇过氧化物以及过氧化氢也都具有有一定的活性。它能以GSH作为还原底物，催化对H2O2、有机氢过氧化物和脂类氢过氧化物的还原反应，从而在生物体的抗氧化过程中发挥非常重要的作用。
发明内容
本发明目的提供一种磷脂氢谷胱甘肽过氧化物酶增强型还原谷胱甘肽的化妆品组合物，有效的提高了还原型谷胱甘肽清除活性氧自由基的能力。
本发明所采用的技术方案为：
一种化妆品组合物，其特征在于：该组合物含有以下组分及含量：
磷脂氢谷胱甘肽过氧化物酶：0.01％-1％；
还原型谷胱甘肽：0.1％-5％；
润肤剂：5％-20％；
极性溶剂：70％-90％；
增稠剂：0.1％-2.5％
表面活性剂0.1％-5％。
本发明所述的一种化妆品组合物中润肤剂为辛酸甘油三酯、葵酸甘油三酯、异硬脂酸甘油三酯、肉豆寇酸乙酸丙二醇酯、羊毛脂、聚丁烯、棕榈酸异丙酯、肉豆寇酸异丙酯、异硬脂酸异丙酯、癸二酸二乙酯、己二酸二异丙酯、生育酚、亚油酸生育酚、硬脂酸十六烷基酯、乳酸乙酯、油酸鲸蜡酯、蓖麻油酸鲸蜡酯、油醇、十六烷基醇、羟基硬脂酸辛酯、辛基十二烷醇、蓖麻油、矿脂、改性羊毛脂、玉米油、棉籽油、橄榄油、棕榈仁油、菜籽油、红花油、霍霍巴油、月见草油、鳄梨油、矿物油、牛油、棕榈酸辛酯、异壬酸异壬酯、二聚酸二异丙醋、棕榈酸辛酯、乙酰基羊毛脂、脂肪酸蔗糖酯、硬脂酸异丙酯、硅油、聚二甲基硅氧烷、尿囊素、异十六烷、异十二烷、凡士林、亚油酸、亚麻酸中的一种或它们中的几种的混合物。
本发明所述的一种化妆品组合物中极性溶剂为水、甘油、丙二醇、丁二醇、己二醇、乙醇中的一种或它们中的几种的混合物。
本发明所述的一种化妆品组合物中增稠剂为槐树豆胶、藻酸钠、酪蛋白酸钠、明胶琼脂、黄原胶、汉生胶、淀粉、化学改性淀粉、羟乙基纤维素、甲基纤维素、羟甲基纤维素、羟丙基甲基纤维素、聚乙烯吡咯烷酮、聚乙烯醇、瓜尔胶、羟丙基瓜尔胶、可溶性淀粉、阳离子纤维素、阳离子瓜耳胶、聚乙烯醇聚丙烯酸聚合物、聚甲基丙烯酸聚合物、聚乙烯基乙酸酯聚合物、交联聚丙稀酸树脂中一种或它们中的几种的混合物。
本发明所述的一种化妆品组合物中表面活性剂为聚山梨酸酯、十六烷基聚氧乙烯醚-6、十六烷基聚氧乙烯醚-10、十六烷基聚氧乙烯醚-12、鲸蜡硬脂酸基聚氧乙烯醚-6、鲸蜡硬脂酸基聚氧乙烯醚-10、鲸蜡硬脂酸基聚氧乙烯醚-12、硬脂基聚氧乙烯醚-6、硬脂基聚氧乙烯醚-10、硬脂基聚氧乙烯醚-12、硬脂基聚氧乙烯醚-21、硬脂基聚氧乙烯醚-100、PEG-6硬脂酸酯、PEG-12硬脂酸酯、PEG-20甘油基硬脂酸酯、PEG-80甘油基牛油酯、PEG-10甘油基硬脂酸酯、PEG-30甘油基椰油酸酯、PEG-10二硬脂酸酯、PEG-100硬脂酸酯、吐温-60、吐温-80、磷脂酰胆碱、氢化磷脂酰胆碱、卵磷脂、溶血磷脂、脑磷脂中的一种或它们中的几种的混合物。
本发明以磷脂氢谷胱甘肽过氧化物酶和还原型谷胱甘肽为活性成分，具有祛除皮肤表面产生的自由基，可以清除皮肤表面产生的自由基，对皮肤起到强有力的保护作用，从而达到美白、祛斑的效果。
附图说明
图1为磷脂氢谷胱甘肽过氧化物酶和还原型谷胱甘肽单独以及联合作用对细胞活力的影响。
具体实施方式
本发明所提供的化妆品组合物含有0.01％-1％的磷脂氢谷胱甘肽过氧化物酶、0.1％-5％的还原型谷胱甘肽、5％-20％的润肤剂、70％-90％的极性溶剂、0.1％-2.5％的增稠剂和0.1％-5％的表面活性剂。
其中所述的润肤剂为辛酸甘油三酯、葵酸甘油三酯、异硬脂酸甘油三酯、肉豆寇酸乙酸丙二醇酯、羊毛脂、聚丁烯、棕榈酸异丙酯、肉豆寇酸异丙酯、异硬脂酸异丙酯、癸二酸二乙酯、己二酸二异丙酯、生育酚、亚油酸生育酚、硬脂酸十六烷基酯、乳酸乙酯、油酸鲸蜡酯、蓖麻油酸鲸蜡酯、油醇、十六烷基醇、羟基硬脂酸辛酯、辛基十二烷醇、蓖麻油、矿脂、改性羊毛脂、玉米油、棉籽油、橄榄油、棕榈仁油、菜籽油、红花油、霍霍巴油、月见草油、鳄梨油、矿物油、牛油、棕榈酸辛酯、异壬酸异壬酯、二聚酸二异丙醋、棕榈酸辛酯、乙酰基羊毛脂、脂肪酸蔗糖酯、硬脂酸异丙酯、硅油、聚二甲基硅氧烷、尿囊素、异十六烷、异十二烷、凡士林、亚油酸、亚麻酸中的一种或它们中的几种的混合物。
所述的极性溶剂为水、甘油、丙二醇、丁二醇、己二醇、乙醇中的一种或它们中的几种的混合物。
所述的增稠剂为槐树豆胶、藻酸钠、酪蛋白酸钠、明胶琼脂、黄原胶、汉生胶、淀粉、化学改性淀粉、羟乙基纤维素、甲基纤维素、羟甲基纤维素、羟丙基甲基纤维素、聚乙烯吡咯烷酮、聚乙烯醇、瓜尔胶、羟丙基瓜尔胶、可溶性淀粉、阳离子纤维素、阳离子瓜耳胶、聚乙烯醇聚丙烯酸聚合物、聚甲基丙烯酸聚合物、聚乙烯基乙酸酯聚合物、交联聚丙稀酸树脂中一种或它们中的几种的混合物。
所述的表面活性剂为聚山梨酸酯、十六烷基聚氧乙烯醚-6、十六烷基聚氧乙烯醚-10、十六烷基聚氧乙烯醚-12、鲸蜡硬脂酸基聚氧乙烯醚-6、鲸蜡硬脂酸基聚氧乙烯醚-10、鲸蜡硬脂酸基聚氧乙烯醚-12、硬脂基聚氧乙烯醚-6、硬脂基聚氧乙烯醚-10、硬脂基聚氧乙烯醚-12、硬脂基聚氧乙烯醚-21、硬脂基聚氧乙烯醚-100、PEG-6硬脂酸酯、PEG-12硬脂酸酯、PEG-20甘油基硬脂酸酯、PEG-80甘油基牛油酯、PEG-10甘油基硬脂酸酯、PEG-30甘油基椰油酸酯、PEG-10二硬脂酸酯、PEG-100硬脂酸酯、吐温-60、吐温-80、磷脂酰胆碱、氢化磷脂酰胆碱、卵磷脂、溶血磷脂、脑磷脂中的一种或它们中的几种的混合物。
其制备方法采用常规制备方法，80℃条件下分别溶解A组分形成水溶液A及溶解B组分形成油溶液B，然后将油溶液B加入水溶液A中，高剪切均质形成溶液，然后保温搅拌0.5h后自然冷却至35℃，最后依次加入组分C，搅拌均匀即可。实施例1-9配方如表1。
表1 实施例1-9化妆品配方表
实施例10
采用MTT法检测细胞存活率。取对数生长期的细胞，按照1×105 cells/mL的浓度接种96孔板，每孔体积200μL，正常培养24h后，向保护组细胞培养液中加入10μg/mL磷脂氢谷胱甘肽过氧化物酶(RsPHGPx)和3mg/mL还原型谷胱甘肽(GSH)，空白对照组只加入等体积的PBS，5min后，分别采用1mM H2O2进行氧化损伤处理6h。氧化损伤处理结束后，取出96孔培养板，弃上清，小心用PBS冲2-3遍后，再加入200μL含0.5mg/mL MTT的新鲜培养液，继续在37℃，5％CO2条件下培养4h。培养结束后，弃去MTT溶液，每孔加入100μL DMSO，振荡混匀，测波长为490nm的各孔吸光度值(A490)，计算细胞存活率，结果如图1磷脂氢谷胱甘肽过氧化物酶和还原型谷胱甘肽单独以及联合作用对细胞活力影响。细胞活力的检测结果，磷脂氢谷胱甘肽过氧化物酶和还原型谷胱甘肽联合作用可以极大地提高细胞活力，与对照组相比有显著性差异，##p＜0.01(n＝5)。
Claims (5)
1.一种化妆品组合物，其特征在于：该组合物含有以下组分及含量：
磷脂氢谷胱甘肽过氧化物酶：0.01％-1％；
还原型谷胱甘肽：0.1％-5％；
润肤剂：5％-20％；
极性溶剂：70％-90％；
增稠剂：0.1％-2.5％
表面活性剂0.1％-5％。
2.按照权利要求1所述的一种化妆品组合物，其特征在于所述的润肤剂为辛酸甘油三酯、葵酸甘油三酯、异硬脂酸甘油三酯、肉豆寇酸乙酸丙二醇酯、羊毛脂、聚丁烯、棕榈酸异丙酯、肉豆寇酸异丙酯、异硬脂酸异丙酯、癸二酸二乙酯、己二酸二异丙酯、生育酚、亚油酸生育酚、硬脂酸十六烷基酯、乳酸乙酯、油酸鲸蜡酯、蓖麻油酸鲸蜡酯、油醇、十六烷基醇、羟基硬脂酸辛酯、辛基十二烷醇、蓖麻油、矿脂、改性羊毛脂、玉米油、棉籽油、橄榄油、棕榈仁油、菜籽油、红花油、霍霍巴油、月见草油、鳄梨油、矿物油、牛油、棕榈酸辛酯、异壬酸异壬酯、二聚酸二异丙醋、棕榈酸辛酯、乙酰基羊毛脂、脂肪酸蔗糖酯、硬脂酸异丙酯、硅油、聚二甲基硅氧烷炕、尿囊素、异十六烷、异十二烷、凡士林、亚油酸和亚麻酸中的一种或它们中的几种的混合物。
3.按照权利要求1所述的一种化妆品组合物，其特征在于所述的极性溶剂为水、甘油、丙二醇、丁二醇、己二醇和乙醇中的一种或它们中的几种的混合物。。
4.按照权利要求1所述的一种化妆品组合物，其特征在于所述的增稠剂为槐树豆胶、藻酸钠、酪蛋白酸钠、明胶琼脂、黄原胶、汉生胶、淀粉、化学改性淀粉、羟乙基纤维素、甲基纤维素、羟甲基纤维素、羟丙基甲基纤维素、聚乙烯吡咯烷酮、聚乙烯醇、瓜尔胶、羟丙基瓜尔胶、可溶性淀粉、阳离子纤维素、阳离子瓜耳胶、聚乙烯醇聚丙烯酸聚合物、聚甲基丙烯酸聚合物、聚乙烯基乙酸酯聚合物和交联聚丙稀酸树脂中的一种或它们中的几种的混合物。
5.按照权利要求1所述的一种化妆品组合物，其特征在于所述的表面活性剂为聚山梨酸酯、十六烷基聚氧乙烯醚-6、十六烷基聚氧乙烯醚-10、十六烷基聚氧乙烯醚-12、鲸蜡硬脂酸基聚氧乙烯醚-6、鲸蜡硬脂酸基聚氧乙烯醚-10、鲸蜡硬脂酸基聚氧乙烯醚-12、硬脂基聚氧乙烯醚-6、硬脂基聚氧乙烯醚-10、硬脂基聚氧乙烯醚-12、硬脂基聚氧乙烯醚-21、硬脂基聚氧乙烯醚-100、PEG-6硬脂酸酯、PEG-12硬脂酸酯、PEG-20甘油基硬脂酸酯、PEG-80甘油基牛油酯、PEG-10甘油基硬脂酸酯、PEG-30甘油基椰油酸酯、PEG-10二硬脂酸酯、PEG-100硬脂酸酯、吐温-60、吐温-80、磷脂酰胆碱、氢化磷脂酰胆碱、卵磷脂、溶血磷脂和脑磷脂中的一种或它们中的几种的混合物。
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103845235A (zh) * | 2014-02-13 | 2014-06-11 | 上海珍馨化工科技有限公司 | 美白化妆品 |
| CN104095778A (zh) * | 2013-04-03 | 2014-10-15 | 上海珍馨化工科技有限公司 | 一种白芨营养面贴膜用乳液、面贴膜及其制备方法 |
| CN104095779A (zh) * | 2013-04-03 | 2014-10-15 | 上海珍馨化工科技有限公司 | 一种人参营养面贴膜用乳液、面贴膜及其制备方法 |
| CN105534753A (zh) * | 2016-01-06 | 2016-05-04 | 苏州宝丽洁日化有限公司 | 一种自微乳化妆水及其制备方法和应用 |
| CN113679628A (zh) * | 2021-09-02 | 2021-11-23 | 广州睿森生物科技有限公司 | 一种综合改善皮肤问题的护肤组合物及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1111055A1 (en) * | 1999-12-08 | 2001-06-27 | Vetigen | Plant enzymes with phospholipid hydroperoxide glutathione peroxidase activity, their analogues and their use |
| CN101536963A (zh) * | 2009-04-22 | 2009-09-23 | 江苏隆力奇生物科技股份有限公司 | 护肤品 |
| DE102009045798A1 (de) * | 2009-10-19 | 2010-08-05 | Henkel Ag & Co. Kgaa | Enzymatische Hautaufhellung |
-
2011
- 2011-04-08 CN CN 201110087940 patent/CN102166164A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1111055A1 (en) * | 1999-12-08 | 2001-06-27 | Vetigen | Plant enzymes with phospholipid hydroperoxide glutathione peroxidase activity, their analogues and their use |
| CN101536963A (zh) * | 2009-04-22 | 2009-09-23 | 江苏隆力奇生物科技股份有限公司 | 护肤品 |
| DE102009045798A1 (de) * | 2009-10-19 | 2010-08-05 | Henkel Ag & Co. Kgaa | Enzymatische Hautaufhellung |
Non-Patent Citations (1)
| Title |
|---|
| 《卫生职业教育》 20040531 孙洪刚等人 谷胱甘肽的代谢和应用 第126页 1-5 第22卷, 第10期 2 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104095778A (zh) * | 2013-04-03 | 2014-10-15 | 上海珍馨化工科技有限公司 | 一种白芨营养面贴膜用乳液、面贴膜及其制备方法 |
| CN104095779A (zh) * | 2013-04-03 | 2014-10-15 | 上海珍馨化工科技有限公司 | 一种人参营养面贴膜用乳液、面贴膜及其制备方法 |
| CN103845235A (zh) * | 2014-02-13 | 2014-06-11 | 上海珍馨化工科技有限公司 | 美白化妆品 |
| CN105534753A (zh) * | 2016-01-06 | 2016-05-04 | 苏州宝丽洁日化有限公司 | 一种自微乳化妆水及其制备方法和应用 |
| CN113679628A (zh) * | 2021-09-02 | 2021-11-23 | 广州睿森生物科技有限公司 | 一种综合改善皮肤问题的护肤组合物及其应用 |
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