CN102161653A - 抑制香草素受体亚型1(vr1)受体的苯并二氢吡喃基脲化合物及其用途 - Google Patents
抑制香草素受体亚型1(vr1)受体的苯并二氢吡喃基脲化合物及其用途 Download PDFInfo
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- CN102161653A CN102161653A CN2011100508496A CN201110050849A CN102161653A CN 102161653 A CN102161653 A CN 102161653A CN 2011100508496 A CN2011100508496 A CN 2011100508496A CN 201110050849 A CN201110050849 A CN 201110050849A CN 102161653 A CN102161653 A CN 102161653A
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- Prior art keywords
- alkyl
- indazole
- urea
- base
- methyl
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- BBFCIBZLAVOLCF-UHFFFAOYSA-N pyridin-1-ium;bromide Chemical compound Br.C1=CC=NC=C1 BBFCIBZLAVOLCF-UHFFFAOYSA-N 0.000 description 1
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- VQMSRUREDGBWKT-UHFFFAOYSA-N quinoline-4-carboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=CC=NC2=C1 VQMSRUREDGBWKT-UHFFFAOYSA-N 0.000 description 1
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- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
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- JNDJUQHDAWUNKN-UHFFFAOYSA-N tert-butyl n-(1,2,3,4-tetrahydroquinolin-4-yl)carbamate Chemical compound C1=CC=C2C(NC(=O)OC(C)(C)C)CCNC2=C1 JNDJUQHDAWUNKN-UHFFFAOYSA-N 0.000 description 1
- FQFILJKFZCVHNH-UHFFFAOYSA-N tert-butyl n-[3-[(5-bromo-2-chloropyrimidin-4-yl)amino]propyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCCNC1=NC(Cl)=NC=C1Br FQFILJKFZCVHNH-UHFFFAOYSA-N 0.000 description 1
- XBXCNNQPRYLIDE-UHFFFAOYSA-N tert-butylcarbamic acid Chemical compound CC(C)(C)NC(O)=O XBXCNNQPRYLIDE-UHFFFAOYSA-N 0.000 description 1
- 125000005942 tetrahydropyridyl group Chemical group 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US63063604P | 2004-11-24 | 2004-11-24 | |
| US60/630636 | 2004-11-24 |
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| CNA2005800467732A Division CN101443327A (zh) | 2004-11-24 | 2005-11-22 | 抑制香草素受体亚型1（vr1）受体的苯并二氢吡喃基脲化合物及其用途 |
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| CNA2005800467732A Pending CN101443327A (zh) | 2004-11-24 | 2005-11-22 | 抑制香草素受体亚型1（vr1）受体的苯并二氢吡喃基脲化合物及其用途 |
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| CNA2005800467732A Pending CN101443327A (zh) | 2004-11-24 | 2005-11-22 | 抑制香草素受体亚型1（vr1）受体的苯并二氢吡喃基脲化合物及其用途 |
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| EP (2) | EP2527339A1 (https=) |
| JP (2) | JP4932730B2 (https=) |
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| CN (2) | CN102161653A (https=) |
| AU (1) | AU2005316972B2 (https=) |
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| MX (1) | MX2007006205A (https=) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025161263A1 (zh) * | 2024-01-31 | 2025-08-07 | 深圳晶蛋生物医药科技有限公司 | 一种苯并吗啉类化合物及其应用 |
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| US8538560B2 (en) | 2004-04-29 | 2013-09-17 | Rosemount Inc. | Wireless power and communication unit for process field devices |
| US8145180B2 (en) * | 2004-05-21 | 2012-03-27 | Rosemount Inc. | Power generation for process devices |
| NZ555318A (en) * | 2004-11-24 | 2011-01-28 | Abbott Lab | Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof |
| US20060160850A1 (en) * | 2005-01-18 | 2006-07-20 | Chongqing Sun | Bicyclic heterocycles as cannabinoid receptor modulators |
| WO2006116165A1 (en) | 2005-04-22 | 2006-11-02 | Wyeth | Chromane and chromene derivatives and uses thereof |
| CN101365684A (zh) * | 2005-10-28 | 2009-02-11 | 艾博特公司 | 抑制trpv1受体的吲唑衍生物 |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| EP2012778A4 (en) * | 2006-04-18 | 2011-08-10 | Abbott Lab | VANILLOID RECEPTOR (VR1) SUBType 1 ANTAGONISTS AND USES THEREOF |
| US7913566B2 (en) | 2006-05-23 | 2011-03-29 | Rosemount Inc. | Industrial process device utilizing magnetic induction |
| WO2008059339A2 (en) * | 2006-11-13 | 2008-05-22 | Glenmark Pharmaceuticals S.A. | Isoquinoline derivatives as vanilloid receptor modulators |
| CA2672196A1 (en) * | 2006-12-20 | 2008-07-03 | Abbott Laboratories | Antagonists of the trpv1 receptor and uses thereof |
| WO2008110863A1 (en) * | 2007-03-15 | 2008-09-18 | Glenmark Pharmaceuticals S.A. | Indazole derivatives and their use as vanilloid receptor ligands |
| WO2009078999A1 (en) | 2007-12-17 | 2009-06-25 | Janssen Pharmaceutica N.V. | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1 |
| WO2009095726A1 (en) * | 2008-01-29 | 2009-08-06 | Glenmark Pharmaceuticals, S.A. | Acrylamide derivatives as vanilloid receptor 1 modulators |
| JP5305704B2 (ja) * | 2008-03-24 | 2013-10-02 | 富士フイルム株式会社 | 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版 |
| US8250924B2 (en) | 2008-04-22 | 2012-08-28 | Rosemount Inc. | Industrial process device utilizing piezoelectric transducer |
| CN102067048B (zh) * | 2008-06-17 | 2017-03-08 | 罗斯蒙特公司 | 用于具有可变压降的现场设备的rf适配器 |
| US8694060B2 (en) | 2008-06-17 | 2014-04-08 | Rosemount Inc. | Form factor and electromagnetic interference protection for process device wireless adapters |
| US8929948B2 (en) | 2008-06-17 | 2015-01-06 | Rosemount Inc. | Wireless communication adapter for field devices |
| CN102084307B (zh) | 2008-06-17 | 2014-10-29 | 罗斯蒙特公司 | 用于具有低压本质安全钳的现场设备的rf适配器 |
| WO2010023512A1 (en) * | 2008-08-28 | 2010-03-04 | Matrix Laboratories Ltd. | Novel vanilloid receptor modulators, process for their preparation and pharmaceutical compositions containing them |
| AR073631A1 (es) * | 2008-10-17 | 2010-11-17 | Abbott Lab | Antagonistas del receptor transitorio potencial de vanilloides 1 ( trpv1) utiles para tratar inflamacion y dolor |
| MX2011004090A (es) * | 2008-10-17 | 2011-05-31 | Abbott Lab | Antagonistas trpv1. |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| CN101654435B (zh) * | 2009-06-09 | 2014-01-29 | 沈阳药科大学 | N-苯甲基喹啉羧酸类化合物、组合物及其制备方法 |
| US20100318007A1 (en) * | 2009-06-10 | 2010-12-16 | O'brien Donald J | Electromechanical tactile stimulation devices and methods |
| US9674976B2 (en) | 2009-06-16 | 2017-06-06 | Rosemount Inc. | Wireless process communication adapter with improved encapsulation |
| US8626087B2 (en) | 2009-06-16 | 2014-01-07 | Rosemount Inc. | Wire harness for field devices used in a hazardous locations |
| IN2012DN01983A (https=) | 2009-08-24 | 2015-07-24 | Ascepion Pharmaceuticals Inc | |
| JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体 |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| JP5748777B2 (ja) | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
| CA2794153C (en) | 2010-03-25 | 2018-01-02 | Glaxosmithkline Llc | Substituted indoline derivatives as perk inhibitors |
| US10761524B2 (en) | 2010-08-12 | 2020-09-01 | Rosemount Inc. | Wireless adapter with process diagnostics |
| EP2688866A1 (en) | 2011-03-25 | 2014-01-29 | AbbVie Inc. | Trpv1 antagonists |
| US9310794B2 (en) | 2011-10-27 | 2016-04-12 | Rosemount Inc. | Power supply for industrial process field device |
| US8859584B2 (en) | 2011-12-19 | 2014-10-14 | Abbvie, Inc. | TRPV1 antagonists |
| US8969325B2 (en) | 2011-12-19 | 2015-03-03 | Abbvie Inc. | TRPV1 antagonists |
| US8796328B2 (en) | 2012-06-20 | 2014-08-05 | Abbvie Inc. | TRPV1 antagonists |
| CN103739547B (zh) * | 2014-01-03 | 2015-09-02 | 沈阳药科大学 | 2-[6-甲氧基-3-(2,3-二氯苯基)甲基-4-氧代-1,4-二氢-1(4h)-喹啉基]乙酸的合成方法 |
| US9783527B2 (en) * | 2014-09-16 | 2017-10-10 | Abbvie Inc. | Indazole ureas and method of use |
| CN109574972A (zh) * | 2018-07-13 | 2019-04-05 | 郑州大学 | 一种3-烷基取代-4-色满酮类化合物及其制备方法 |
| IL301691A (en) * | 2020-09-30 | 2023-05-01 | Univ Leuven Kath | 1,2,3,4-tetrahydroquinoline derivatives as inhibitors of the yap/taz-tead activation for treating cancer |
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| EP0386839B1 (en) * | 1989-03-08 | 1997-01-15 | Merck Sharp & Dohme Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
| NL8900565A (nl) | 1989-03-08 | 1990-10-01 | Philips Nv | Methode voor de verwerking van een radio data signaal, alsmede ontvanger voor de uitvoering van deze methode. |
| US5374643A (en) | 1992-09-11 | 1994-12-20 | E. R. Squibb & Sons, Inc. | Aryl urea (thiourea) and cyanoguanidine derivatives |
| JP2000516958A (ja) * | 1996-08-26 | 2000-12-19 | ジェネティックス・インスチチュート・インコーポレーテッド | ホスホリパーゼ酵素の阻害剤 |
| EP1232150B1 (en) * | 1999-11-16 | 2007-10-10 | Boehringer Ingelheim Pharmaceuticals Inc. | Urea derivatives as anti-inflammatory agents |
| WO2003097586A1 (en) * | 2002-05-17 | 2003-11-27 | Janssen Pharmaceutica N.V. | Aminotetralin-derived urea modulators of vanilloid vr1 receptor |
| EP1601665A2 (en) | 2003-03-07 | 2005-12-07 | Glaxo Group Limited | Urea derivatives |
| NZ555318A (en) * | 2004-11-24 | 2011-01-28 | Abbott Lab | Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof |
| CN101365684A (zh) * | 2005-10-28 | 2009-02-11 | 艾博特公司 | 抑制trpv1受体的吲唑衍生物 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025161263A1 (zh) * | 2024-01-31 | 2025-08-07 | 深圳晶蛋生物医药科技有限公司 | 一种苯并吗啉类化合物及其应用 |
Also Published As
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| CA2588909A1 (en) | 2006-06-22 |
| US7812019B2 (en) | 2010-10-12 |
| EP1844038A2 (en) | 2007-10-17 |
| KR20120137420A (ko) | 2012-12-20 |
| WO2006065484A3 (en) | 2009-02-19 |
| US8440691B2 (en) | 2013-05-14 |
| JP2012111766A (ja) | 2012-06-14 |
| KR101250824B1 (ko) | 2013-04-05 |
| AU2005316972A1 (en) | 2006-06-22 |
| US20060128689A1 (en) | 2006-06-15 |
| EP2527339A1 (en) | 2012-11-28 |
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| AU2005316972B2 (en) | 2011-11-10 |
| IL183321A0 (en) | 2008-04-13 |
| KR20070086607A (ko) | 2007-08-27 |
| US20110152250A1 (en) | 2011-06-23 |
| CN101443327A (zh) | 2009-05-27 |
| JP4932730B2 (ja) | 2012-05-16 |
| WO2006065484A2 (en) | 2006-06-22 |
| JP2008532925A (ja) | 2008-08-21 |
| TW200633712A (en) | 2006-10-01 |
| NZ555318A (en) | 2011-01-28 |
| BRPI0518581A2 (pt) | 2008-11-25 |
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