CN102138940A - Preparation method of termitarium capsule - Google Patents
Preparation method of termitarium capsule Download PDFInfo
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- CN102138940A CN102138940A CN2011100716056A CN201110071605A CN102138940A CN 102138940 A CN102138940 A CN 102138940A CN 2011100716056 A CN2011100716056 A CN 2011100716056A CN 201110071605 A CN201110071605 A CN 201110071605A CN 102138940 A CN102138940 A CN 102138940A
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Abstract
The invention discloses a preparation method of a termitarium capsule, comprising the following steps of: removing impurities from termitaria, pulverizing to form fine termitarium powder of 80 meshes, drying the termitarium powder, controlling the temperature at 85-100 DEG C and the humidity below 3.0% to obtain the pure termitarium medicinal material; sterilizing the pure termitarium medicinal material by 60 Co-gamma irradiation for 3-5 hours, blending for 10-30 minutes to obtain the intermediate of the termitarium capsule; and filling the intermediate of the termitarium capsule into capsules and polishing to obtain the finished product of the termitarium capsule. Compared with the prior art, the invention has the advantages of good curative effects, no toxic side effects, scientific process and notable drug effects in clinical use, and the prepared termitarium capsule contains a big amount of active components.
Description
Technical field
The present invention relates to a kind of production method of Chinese medicinal capsule, relate in particular to the capsular production method of a kind of termitarium.
Background technology
Coptotermes formosanus Shtrari. is one of five universally acknowledged major pests, and however, Coptotermes formosanus Shtrari. itself has edibility and medical value, and the termitarium fungus garden is that Coptotermes formosanus Shtrari. is formed with microorganisms such as particular form cultivation funguses, also is delicious dish.Coptotermes formosanus Shtrari. is the Insecta Isoptera, contains the several amino acids and the various trace elements of needed by human body.The Coptotermes formosanus Shtrari. campsite is life down, lives in caves moist ecological environment and huge life and fertility are arranged, even Coptotermes formosanus Shtrari. death can mouldyly not rotted in nest yet.Termitarium is the dry body of Coptotermes formosanus Shtrari. colony and fungus garden thereof.Wherein, Coptotermes formosanus Shtrari. mainly is Odontotermes formosanus Shiraki (Odontotermes formosanus Shiraki) or Macrotermes barneyi Light (Macrotermes barneyiLight), and fungus garden is based on termitomyces (Termitomyces albuminosus (Berk) Heim).
The medical value of relevant Coptotermes formosanus Shtrari. and fungus garden thereof, existing correlational study and report in Chinese medicine.Li Shizhen (1518-1593 A.D.) is write in Compendium of Material Medica: " with person on the Masson Pine, each is fried and deceives with Plumbum preparatium for Coptotermes formosanus Shtrari. mud, purport malignant boil toxic swelling, grinds with fragrant stain and is coated with it, and getting more is to end ", " abnormal smells from the patient is sweet, flat, nontoxic for termitomyces.Cure mainly stomach reinforcing, clear refreshing, control hemorrhoid "." middle traditional Chinese medicines sea " points out that also its meridian distribution of property and flavor is " sweet, flat.Nontoxic.Go into the heart, lung, spleen three warps, it is refreshing clearly to cure mainly invigorating the spleen and regulating the stomach, QI invigorating." Chinese invention patent (CN95107728.7) of unit application such as the FOREST PROTECT INST CHINA FORE weight ratio that " comprises the application of the pharmaceutical composition of termite population and main nest bacterial nursery thereof " and disclose Odontotermes formosanus Shiraki and termite nest fungus comb is 1: 15-20 is used for the treatment of chronic hepatitis, anti-inflammatory analgesic, treatment of arthritis, infertility.The medicine manufacture process that existing Coptotermes formosanus Shtrari. and fungus garden thereof are made is loaded down with trivial details, need through multiple working procedure, spray-dired method behind common use high-temperature sterilization or the alcohol/water extraction, making wherein, effective ingredient descends, influence its medical value, the processing of termitarium also lacks certain quality and guarantees, is mainly reflected in the virus killing sterilization.
Summary of the invention
Goal of the invention: the present invention improves the effective ingredient in pharmacy efficient and the medicine in order to overcome the deficiencies in the prior art, provides a kind of termitarium capsular production method.
Technical scheme: for achieving the above object, the capsular production method of a kind of termitarium of the present invention, its step is as follows:
(1) get termitarium and remove impurity after, be crushed to 80 order fine powders with the 30B pulverizer and obtain the termitarium powder;
(2) the termitarium powder is carried out drying in heated-air circulation oven, temperature is controlled at 85～100 ℃, and moisture Control obtains the clean medical material of termitarium below 3.0%;
(3) the clean medical material of termitarium is used
60Co-γ irradiation sterilization 3～5 hours always mixes and obtains termitarium capsule intermediate after 10～30 minutes;
(4) termitarium capsule intermediate is carried out capsule charge, polishing gets capsule finished product.
Wherein, described termitarium is the mixture of Coptotermes formosanus Shtrari. and fungus garden of Odontotermes formosanus, Coptotermes formosanus Shtrari. is a kind of of Odontotermes formosanus Shiraki (Odontotermes formosanus Shiraki) or Macrotermes barneyi Light (Macrotermes barneyi Light), and fungus garden comprises termitomyces (Termitomyces albuminosus (Berk) Heim).
Wherein, the described termitarium remove impurity of step (1) operation is mud film, the fragment of choosing in the termitarium fungus garden.Step (4) is carried out at 300,000 grades of clean areas, and relative humidity is 45～65%, and indoor temperature is 18～26 ℃.
Beneficial effect: the present invention compared with prior art, good effect has no side effect, it is many that the termitarium capsule that makes contains effective composition, the operation science, clinical use drug effect is remarkable.
The specific embodiment
Below by embodiment, technical solution of the present invention is elaborated.
Embodiment 1: get the Odontotermes formosanus Shiraki termitarium, choose non-medicinal parts such as mud film in the termitarium fungus garden, fragment, be crushed to 80 order fine powders with the 30B Universalpulverizer and obtain the termitarium powder.Place heated-air circulation oven dry in the termitarium powder, temperature is controlled at 85 ℃, and moisture Control obtains the clean medical material of termitarium below 3.0%, goes into clean medical material storehouse and please examine.After meeting the requirements, check uses
60Co-γ irradiation sterilization 4 hours carries out the clean medical material of termitarium always to mix with the two dimensional motion mixer at 300,000 grades of clean areas, and incorporation time is 15 minutes, obtains termitarium capsule intermediate, and the uniformity, the moisture of termitarium capsule intermediate are tested.Capsule charge carries out at 300,000 grades of clean areas, with NJP-1200C type capsule filler filling termitarium capsule intermediate, got 9 (one group) every 15 minutes and check loading amount (every standard loading amount 0.25g), the control content uniformity is ± 8.0%, and loading amount is adjusted in attention at any time, the capsule that filling is good carries out polishing by standard under the environment of 18～26 ℃ of relative humiditys 45～65%, indoor temperature, obtain the termitarium capsule finished product.
Embodiment 2: get the Macrotermes barneyi Light termitarium, choose non-medicinal parts such as mud film in the termitarium fungus garden, fragment, be crushed to 80 order fine powders with the 30B Universalpulverizer and obtain the termitarium powder.Place heated-air circulation oven dry in the termitarium powder, temperature is controlled at 100 ℃, and moisture Control obtains the clean medical material of termitarium below 3.0%, goes into clean medical material storehouse and please examine.After meeting the requirements, check uses
60Co-γ irradiation sterilization 4 hours carries out the clean medical material of termitarium always to mix with the two dimensional motion mixer at 300,000 grades of clean areas, and incorporation time is 15 minutes, obtains termitarium capsule intermediate, and the uniformity, the moisture of termitarium capsule intermediate are tested.Capsule charge carries out at 300,000 grades of clean areas, with NJP-1200C type capsule filler filling termitarium capsule intermediate, got 9 (one group) every 15 minutes and check loading amount (every standard loading amount 0.25g), the control content uniformity is ± 8.0%, and loading amount is adjusted in attention at any time, the capsule that filling is good carries out polishing by standard under the environment of 18～26 ℃ of relative humiditys 45～65%, indoor temperature, obtain the termitarium capsule finished product.
Embodiment 3: get the Odontotermes formosanus Shiraki termitarium, choose non-medicinal parts such as mud film in the termitarium fungus garden, fragment, be crushed to 80 order fine powders with the 30B Universalpulverizer and obtain the termitarium powder.Place heated-air circulation oven dry in the termitarium powder, temperature is controlled at 90 ℃, and moisture Control obtains the clean medical material of termitarium below 3.0%, goes into clean medical material storehouse and please examine.After meeting the requirements, check uses
60Co-γ irradiation sterilization 3 hours carries out the clean medical material of termitarium always to mix with the two dimensional motion mixer at 300,000 grades of clean areas, and incorporation time is 10 minutes, obtains termitarium capsule intermediate, and the uniformity, the moisture of termitarium capsule intermediate are tested.Capsule charge carries out at 300,000 grades of clean areas, with NJP-1200C type capsule filler filling termitarium capsule intermediate, got 9 (one group) every 15 minutes and check loading amount (every standard loading amount 0.25g), the control content uniformity is ± 8.0%, and loading amount is adjusted in attention at any time, the capsule that filling is good carries out polishing by standard under the environment of 18～26 ℃ of relative humiditys 45～65%, indoor temperature, obtain the termitarium capsule finished product.
Embodiment 4: get the Macrotermes barneyi Light termitarium, choose non-medicinal parts such as mud film in the termitarium fungus garden, fragment, be crushed to 80 order fine powders with the 30B Universalpulverizer and obtain the termitarium powder.Place heated-air circulation oven dry in the termitarium powder, temperature is controlled at 100 ℃, and moisture Control obtains the clean medical material of termitarium below 3.0%, goes into clean medical material storehouse and please examine.After meeting the requirements, check uses
60Co-γ irradiation sterilization 5 hours carries out the clean medical material of termitarium always to mix with the two dimensional motion mixer at 300,000 grades of clean areas, and incorporation time is 30 minutes, obtains termitarium capsule intermediate, and the uniformity, the moisture of termitarium capsule intermediate are tested.Capsule charge carries out at 300,000 grades of clean areas, with NJP-1200C type capsule filler filling termitarium capsule intermediate, got 9 (one group) every 15 minutes and check loading amount (every standard loading amount 0.25g), the control content uniformity is ± 8.0%, and loading amount is adjusted in attention at any time, the capsule that filling is good carries out polishing by standard under the environment of 18～26 ℃ of relative humiditys 45～65%, indoor temperature, obtain the termitarium capsule finished product.
Embodiment 5: the termitarium capsule that production method of the present invention is produced has better anti-inflammatory and analgesic effect with respect to the termitarium capsule that prior art provides.
Test group is selected from the termitarium capsule intermediate that the embodiment of the invention 1 provides; Matched group makes the termitarium capsule according to the method that Chinese patent (CN95107728.7) embodiment 1 provides, and gets dry powder wherein.Termitarium capsule intermediate and dry powder add the vibration of 9% normal saline respectively and place 4 ℃ of refrigerators standby for suspension.48 of test mices, body weight 17-20g, male and female half and half, be divided into 6 groups, 8 every group, as the following table administration, every group of mice taken 7 days continuously, the 8th day in mice left side ear melted paraxylene 0.05ml, weigh respectively at getting mice left and right sides ear auricle with diameter 9mm card punch behind 10min, the 20min, the difference of left and right sides auricle weight is represented the anti-inflammatory degree.
Conclusion: the capsular resist inflammation on repercussive function of termitarium that the capsular production method of termitarium provided by the invention is produced is better than prior art, the termitarium capsule drug effect that gets the capsular production method production of termitarium provided by the invention from the contrast of C combination F group is more lasting, and effective ingredient wherein is more.
The above only is a preferred implementation of the present invention; be noted that for those skilled in the art; under the prerequisite that does not break away from the principle of the invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (4)
1. capsular production method of termitarium is characterized in that adopting following steps:
(1) get termitarium and remove impurity after, be crushed to 80 order fine powders and obtain the termitarium powder;
(2) the termitarium powder is carried out drying, temperature is controlled at 85～100 ℃, and moisture Control obtains the clean medical material of termitarium below 3.0%;
(3) the clean medical material of termitarium is used
60Co-γ irradiation sterilization 3～5 hours always mixes and obtains termitarium capsule intermediate after 10～30 minutes;
(4) termitarium capsule intermediate is carried out capsule charge, polishing gets capsule finished product.
2. the capsular production method of termitarium according to claim 1, it is characterized in that: described termitarium is the mixture of Coptotermes formosanus Shtrari. and fungus garden of Odontotermes formosanus, Coptotermes formosanus Shtrari. is a kind of of Odontotermes formosanus Shiraki (Odontotermes formosanusShiraki) or Macrotermes barneyi Light (Macrotermes barneyi Light), and fungus garden comprises termitomyces (Termitomyces albuminosus (Berk) Heim).
3. the capsular production method of termitarium according to claim 1 is characterized in that: the described termitarium remove impurity of step (1) operation is mud film, the fragment of choosing in the termitarium fungus garden.
4. the capsular production method of termitarium according to claim 1 is characterized in that: step (4) is carried out at 300,000 grades of clean areas, and relative humidity is 45～65%, and indoor temperature is 18～26 ℃.
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| CN2011100716056A CN102138940B (en) | 2011-03-24 | 2011-03-24 | Preparation method of termitarium capsule |
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| CN2011100716056A CN102138940B (en) | 2011-03-24 | 2011-03-24 | Preparation method of termitarium capsule |
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| CN102138940B CN102138940B (en) | 2012-07-04 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098628A (en) * | 1994-06-02 | 1995-02-15 | 陈远传 | Coptotermes formosanus Shtrari. and bacterium plot series preparations thereof |
| CN1139553A (en) * | 1995-06-30 | 1997-01-08 | 中国林业科学研究院森林保护研究所 | Application of medicinal combination containing termite population and main nest bacterial nursery |
| CN101069698A (en) * | 2006-05-12 | 2007-11-14 | 江西中医学院 | Method for preparing termite fugus gardens extract and use thereof |
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2011
- 2011-03-24 CN CN2011100716056A patent/CN102138940B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098628A (en) * | 1994-06-02 | 1995-02-15 | 陈远传 | Coptotermes formosanus Shtrari. and bacterium plot series preparations thereof |
| CN1139553A (en) * | 1995-06-30 | 1997-01-08 | 中国林业科学研究院森林保护研究所 | Application of medicinal combination containing termite population and main nest bacterial nursery |
| CN101069698A (en) * | 2006-05-12 | 2007-11-14 | 江西中医学院 | Method for preparing termite fugus gardens extract and use thereof |
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| CN102138940B (en) | 2012-07-04 |
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