CN108653474A - A kind of drug and preparation method thereof for treating children's hyperkinetic syndrome - Google Patents
A kind of drug and preparation method thereof for treating children's hyperkinetic syndrome Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a kind of drugs and preparation method thereof for treating children's hyperkinetic syndrome, it is prepared according to a certain weight ratio by the fruit of glossy privet, the fruit of Chinese wolfberry, Radix Paeoniae Alba, oyster, mother-of-pearl, Polygonum multiflower knotweed, drug of the present invention has the function of nourshing kidney, nourishing blood and liver, holds back cloudy checking exuberance of yang, resolving sputum, mental-tranquilization, dredging collateral, children's hyperkinetic syndrome is quick, good effect for treating, and does not recur.
Description
Technical field
The present invention relates to a kind of drugs and preparation method thereof for treating children's hyperkinetic syndrome, belong to the field of Chinese medicines.
Technical background
Children's hyperkinetic syndrome is also known as attention deficit-hyperactivity disorder (ADHD) or attention deficit hyperactivity disorder syndrome, is a kind of normal
The child behavior abnormal diseases seen, the normal intelligence of this kind of infant or normal, but have in terms of study, behavior and mood scarce
It falls into.Chinese medicine then thinks to disturb in children's hyperkinetic syndrome and the deficiency of liver-yin and kidney-yin, the insufficiency of heart and spleen, convulsive seizure due to phlegm-fire related.Since western medicine side effect is big,
Therefore there are great demands to the Chinese medicine of effectively treating children's hyperkinetic syndrome by people, up to now, it has not been found that about
The related report of the present invention.
Invention content
Repeatedly verification of the present inventor according to research and the clinical test of theory of traditional Chinese medical science has finally found effectively treatment children
The drug of hyperactivity, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine compositions of effective treatment children's hyperkinetic syndrome.
Another aim of the present invention is to provide the preparation methods of the Chinese medicine composition.
The present invention is that the fruit of glossy privet, the fruit of Chinese wolfberry, Radix Paeoniae Alba, oyster, mother-of-pearl, Polygonum multiflower knotweed drug is selected to be combined preparation,
Each efficacy of drugs is made to generate synergistic effect these pharmaceutical compositions, so as to effectively treat children's hyperkinetic syndrome.Wherein, it selects
The fruit of glossy privet is to enter liver and kidney channel because of its sweet and neutral bitter in taste, have filling liver kidney, the function of strong waist and knee to control yin asthenia generating intrinsic heat, dizzy, mesh
Flower tinnitus, soreness and weakness of waist and knees, poliosis.It is to have a nourshing kidney because of its nature and flavor sweet and neutral to select the fruit of Chinese wolfberry, moistening lung, tonifying liver, improving eyesight
Function controls liver-kidney Yin deficiency, and soreness and weakness of waist and knees is had a dizzy spell, and the more tears of blurred vision, cough due to consumptive disease is quenched one's thirst, seminal emission.Select Radix Paeoniae Alba be because
Its nature and flavor picric acid, it is cool, enter liver, the spleen channel, there is nourishing blood and liver, analgesic in delaying holds back the cloudy function of receiving sweat, controls chest and abdomen pain over the hypochondriac region, rush down
Dysentery abdominal pain, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, under.Select oyster be because its nature and flavor it is salty and bitter, it is cool, enter liver,
Kidney channel, holds back the moon, checking exuberance of yang, hidroschesis, puckery essence, resolving sputum, the function of softening hard masses, Zhi Jing Epilepsy, dizziness, spontaneous perspiration, night sweat, and seminal emission, stranguria with turbid discharge collapses
Leakage, under, scrofula, goiter and tumor.It selects mother-of-pearl and is because its nature and flavor is salty, it is cool, enter the heart, liver two passes through, there is a soothing the liver, checking exuberance of yang, arresting convulsion, only
The function of blood controls dizzy, tinnitus, palpitaition, insomnia, demented , Jing Epilepsy, haematemesis, bleeding from five sense organs or subcutaneous tissue, metrorrhagia.Select Polygonum multiflower knotweed be because
Its property sweet and slightly bitter taste puts down, enters the heart, Liver Channel, there is nourishing heart, calms the nerves, and dredging collateral, the function of wind-dispelling controls insomnia, internal lesion caused by overexertion, hidrosis, deficiency of blood body
Bitterly, ulcer, scrofula, wind sore scabies tinea.
The drug dose of instant component is also to be obtained by plenty of explorations of the inventor, and the dosage of each component is under
It states all to have in weight range and have a better effect：
10-20 grams of the fruit of glossy privet, 10-15 grams of the fruit of Chinese wolfberry, 5-15 grams of Radix Paeoniae Alba, 10-15 grams of oyster, 5-15 grams of mother-of-pearl, Polygonum multiflower knotweed 10-
15 grams.
Preferably
15 grams of the fruit of glossy privet, 12 grams of the fruit of Chinese wolfberry, 10 grams of Radix Paeoniae Alba, 12 grams of oyster, 10 grams of mother-of-pearl, 12 grams of Polygonum multiflower knotweed.
The preparation method of drug of the present invention is as follows
One, it stocks up
1, the fruit of glossy privet：Impurity is picked, cleans, dries；
2, the fruit of Chinese wolfberry：It winnows with a dustpan net impurity, plucks remaining stalk and the base of a fruit；
3, Radix Paeoniae Alba：Impurity is picked, size is separated, is soaked in water to eighty per cant thoroughly, pulls out, solarization is dried in the air, and is moistened to uniform humidity inside and outside, is cut
Piece, it is dry；
4, oyster：It cleans, dries, smash use；
5, mother-of-pearl：Impurity is picked, knock fragment weeds out grey bits；
6, Polygonum multiflower knotweed：Clear water is cleaned, and is slightly impregnated, is pulled out, after moisturizing, segment is dried.
Two, it prepares
1, the fruit of glossy privet of the weight, the fruit of Chinese wolfberry, Radix Paeoniae Alba, oyster, mother-of-pearl, Polygonum multiflower knotweed are put into decocting container, add 5 times of water
Amount, after impregnating 100 minutes, high heat decoction boiling, then with being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, it will for the first time
Decoction liquor is poured into container；
2, the dregs of a decoction of filtering are added into 2 times of amounts of water, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；
3, it decoction liquor will be mixed evenly twice, and be divided into 3 doses and take.
The function of fruit of glossy privet filling liver kidney in prescription, strong waist and knee is monarch drug in a prescription；Oyster holds back the moon, checking exuberance of yang, hidroschesis, puckery essence, resolving sputum,
The function of softening hard masses is ministerial drug, and two taste medicines play nourshing kidney, nourishing blood and liver, hold back cloudy checking exuberance of yang, resolving sputum, improving eyesight, the slow middle work relieved pain jointly
With, treatment children's hyperkinetic syndrome effect is comprehensive, and with kidney, nourishing blood and liver, hold back cloudy checking exuberance of yang, based on resolving sputum, can effect a permanent cure；Mother-of-pearl has flat
The function of liver, checking exuberance of yang, arresting convulsion, hemostasis is adjutant；Polygonum multiflower knotweed has nourishing heart, calms the nerves, dredging collateral, and the function of wind-dispelling is to make with remaining all medicines
Medicine is to take stopgap measures.
Drug of the present invention has the function of nourshing kidney, nourishing blood and liver, holds back cloudy checking exuberance of yang, resolving sputum, mental-tranquilization, dredging collateral, for controlling
Treat children's hyperkinetic syndrome, short treating period, quick, non-relapse after healing.
Specific implementation mode：
Carry out the advantageous effect of the present invention is further explained the drug below by way of test example, these test examples include medicine of the present invention
The animal toxicity test report of object and clinical observation on the therapeutic effect data.
The animal toxicity test of [test example 1] drug of the present invention is reported：
Rabbit 30, male and female dual-purpose, 2.0-2.5kg of weight is taken to be divided to two groups, every group 15, one of which is tested for overdose
Group, another group is normal amount test group.Super quantity group is 20ml/kg, normal amount 10ml/kg, and administering mode gives for administration by gavage
Medicine even served 7 days twice daily, the reaction of observation administration daily, the results showed that two groups of rabbit activities, diet are normal, and drug is without bad
Toxic side effect.
The clinical observation on the therapeutic effect of [test example 2] drug of the present invention
1, general information
Accept children's hyperkinetic syndrome out-patient totally 36 for medical treatment.
2, diagnostic criteria
Classical symptom is：It is absent minded, pay attention to of short duration, hyperactivity, the inflammable, difficulty of learning of mood etc..
3, therapy
Above-mentioned medicament is selected, is taken to patient, each taking 1 dose, early daily, evening respectively takes 1 time, and 7 days as a course for the treatment of, continuous to take
With 3 courses for the treatment of.
4, efficacy assessment standard
It is effective：Children's hyperkinetic syndrome symptom disappears, and restores normal, recovery from illness；
It improves：The phenomenon that patient is absent minded, pays attention to of short duration, hyperactivity, and mood is inflammable, difficulty of learning mitigates, small
The symptoms were significantly improved for youngster's hyperactivity, gradually restores normal；
In vain：Improvement standard person is not achieved.
5, treatment results（It see the table below）
In above-mentioned treatment, with drug therapy children's hyperkinetic syndrome patient 36 of the present invention, as a result effective 31, obvious effective rate is
86.11%, it improves 4, improvement rate 11.11%, invalid 1, total effective rate 97.22%.
Claims (3)
1. a kind of drug for treating children's hyperkinetic syndrome, it is characterised in that：It is made of the bulk pharmaceutical chemicals in following weight range：
10-20 grams of the fruit of glossy privet, 10-15 grams of the fruit of Chinese wolfberry, 5-15 grams of Radix Paeoniae Alba, 10-15 grams of oyster, 5-15 grams of mother-of-pearl, Polygonum multiflower knotweed 10-
15 grams.
2. drug according to claim 1, wherein the dosage of each bulk pharmaceutical chemicals is：
15 grams of the fruit of glossy privet, 12 grams of the fruit of Chinese wolfberry, 10 grams of Radix Paeoniae Alba, 12 grams of oyster, 10 grams of mother-of-pearl, 12 grams of Polygonum multiflower knotweed.
3. the preparation method of drug according to claim 1 or claim 2, it includes the following steps：
（One）Stock
（1）The fruit of glossy privet：Impurity is picked, cleans, dries；
（2）The fruit of Chinese wolfberry：It winnows with a dustpan net impurity, plucks remaining stalk and the base of a fruit；
（3）Radix Paeoniae Alba：Impurity is picked, size is separated, is soaked in water to eighty per cant thoroughly, pulls out, solarization is dried in the air, profit to uniform humidity inside and outside,
Slice, it is dry；
（4）Oyster：It cleans, dries, smash use；
（5）Mother-of-pearl：Impurity is picked, knock fragment weeds out grey bits；
（6）Polygonum multiflower knotweed：Clear water is cleaned, and is slightly impregnated, is pulled out, after moisturizing, segment is dried；
（Two）It prepares
（1）The fruit of glossy privet of the weight, the fruit of Chinese wolfberry, Radix Paeoniae Alba, oyster, mother-of-pearl, Polygonum multiflower knotweed are put into decocting container, water 5 is added
It measures again, after impregnating 100 minutes, high heat decoction boiling, then with being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, by first
Secondary decoction liquor is poured into container；
（2）The dregs of a decoction of filtering are added into 2 times of amounts of water, are boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；
（3）It decoction liquor will be mixed evenly twice, and be divided into 3 doses and take.
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| CN201810854882.6A CN108653474A (en) | 2018-07-31 | 2018-07-31 | A kind of drug and preparation method thereof for treating children's hyperkinetic syndrome |
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| CN201810854882.6A CN108653474A (en) | 2018-07-31 | 2018-07-31 | A kind of drug and preparation method thereof for treating children's hyperkinetic syndrome |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116370577A (en) * | 2023-03-27 | 2023-07-04 | 上海交通大学医学院附属新华医院 | Traditional Chinese medicine composition for treating hyperactivity and preparation method thereof |
-
2018
- 2018-07-31 CN CN201810854882.6A patent/CN108653474A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116370577A (en) * | 2023-03-27 | 2023-07-04 | 上海交通大学医学院附属新华医院 | Traditional Chinese medicine composition for treating hyperactivity and preparation method thereof |
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