CN108403762A - A kind of drug and preparation method thereof for treating migraine - Google Patents
A kind of drug and preparation method thereof for treating migraine Download PDFInfo
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- CN108403762A CN108403762A CN201810409447.2A CN201810409447A CN108403762A CN 108403762 A CN108403762 A CN 108403762A CN 201810409447 A CN201810409447 A CN 201810409447A CN 108403762 A CN108403762 A CN 108403762A
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- 239000003814 drug Substances 0.000 title claims abstract description 32
- 229940079593 drug Drugs 0.000 title claims abstract description 26
- 208000019695 Migraine disease Diseases 0.000 title claims abstract description 17
- 206010027599 migraine Diseases 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 241000951473 Schizonepeta Species 0.000 claims abstract description 13
- 241000522620 Scorpio Species 0.000 claims abstract description 12
- 239000009490 scorpio Substances 0.000 claims abstract description 12
- 241000758794 Asarum Species 0.000 claims abstract description 11
- 241000255789 Bombyx mori Species 0.000 claims abstract description 11
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 11
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- 235000004357 Mentha x piperita Nutrition 0.000 claims abstract description 11
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 239000012535 impurity Substances 0.000 claims description 14
- 241000125175 Angelica Species 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 4
- 239000008188 pellet Substances 0.000 claims description 3
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/236—Ligusticum (licorice-root)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/268—Asarum (wild ginger)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention discloses a kind of drugs and preparation method thereof for treating migraine, it is prepared according to a certain weight ratio by peppermint, asarum, Rhizoma Chuanxiong, schizonepeta, the windproof, root of Dahurain angelica, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae, the larva of a silkworm with batrytis, scorpio, drug of the present invention, which has, delivers wind-dispelling, expel endogenous wind to relieve convulsion, promote breath and open depression dispels pathogenic wind and remove dampness, the function of promoting blood circulation and stopping pain, migraine is quick, good effect for treating, and does not recur.
Description
Technical field
The present invention relates to a kind of drugs and preparation method thereof for treating migraine, belong to the field of Chinese medicines.
Background technology
Migraine is clinical most common primary headaches type, clinical based on ictal middle severe, beating sample headache
It shows, headache is mostly inclined side, generally continues 4~72 hours, can be with Nausea and vomiting, light, Sound stimulat or daily routines
Headache is aggravated, quiet environment, rest can alleviate headache.Migraine is a kind of common chronic forms vascular illness, a lot of diseases
In children and puberty, the young and middle-aged phase reaches onset peak, and women is common, and men and women's Proportion of patients is about 1: 2~3, illness in crowd
Rate is 5%~10%, often there is genetic background.Since western medicine side effect is big, people are to effectively treating the Chinese medicine of migraine
There are great demands for drug, up to now, it has not been found that the related report about the present invention.
Invention content
The present inventor is on the basis of hospital handed down from one's ancestors, and the verification repeatedly Jing Guo clinical test, has finally found and effectively controls
The drug of migraine is treated, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine compositions of effective treatment migraine.
Another aim of the present invention is to provide the preparation methods of the Chinese medicine composition.
Drug of the present invention be selection peppermint, asarum, Rhizoma Chuanxiong, schizonepeta, the windproof, root of Dahurain angelica, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae, the larva of a silkworm with batrytis, scorpio into
Prepared by row combination, make each efficacy of drugs generate synergistic effect these pharmaceutical compositions, so as to effectively treat migraine.
Wherein select peppermint be because its nature and flavor is pungent, it is cool, enter lung, Liver Channel, there is dispelling wind, radiate, ward off dirty, the function of removing toxic substances controls diseases caused by external factors wind
Heat, headache, hot eyes, abscess of throat, food stagnation inflatable, aphtha, toothache, sore scabies, urticaria.Select asarum be because its nature and flavor it is acrid in flavour and warm in nature,
Enter lung, kidney channel, there is wind-dispelling, cold dispelling, row water to open function surreptitiously, controls air-cooled headache, nasosinusitis, analgesic, phlegm and retained fluid cough is inverse, arthralgia pain due to rheumatism.
It is to enter liver, gallbladder channel because its nature and flavor is acrid in flavour and warm in nature, there is promote breath and open depression, dispel pathogenic wind and remove dampness, the function of promoting blood circulation and stopping pain is controlled air-cooled to select Rhizoma Chuanxiong
Headache rotation is dizzy, hypochondriac pain abdomen pain, arthritis muscle contraction, Amenorrhea, difficult labour, postpartum stasis block pain, ulcer sores.It is because of its property to select schizonepeta
Taste is acrid in flavour and warm in nature, enters lung, Liver Channel, delivers, wind-dispelling, the function of regulating blood condition, fries charcoal hemostasis, and cure cold fever, headache, abscess of throat, in
Air port is kept silent, and is spitted blood, and bleeding from five sense organs or subcutaneous tissue is had blood in stool, uterine bleeding, postpartum anemic fainting, carbuncle swells, sore scabies, scrofula.Select it is windproof be because of its property acrid-sweet flavor,
Temperature enters bladder, lung, the spleen channel, delivers, wind-dispelling, and victory is wet, and the function of analgesic is controlled and caught cold, headache, dizzy, Xiang Qiang, chill
Arthritis with fixed pain caused by dampness, skeletal pain, four limbs contraction is anxious, lockjaw.It is to enter lung, spleen, stomach because its nature and flavor is acrid in flavour and warm in nature, there is wind-dispelling to select the root of Dahurain angelica,
Eliminating dampness, detumescence, the function of analgesic control headache, pain in the supra-orbital bone, dentalgia, nasosinusitis, cold-dampness stomachache, intestines wind anal fistula, leukorrhea with reddish discharge, carbuncle
Subcutaneous ulcer sore, skin itchy, mange.It is because its nature and flavor is arduous to select Rhizoma Et Radix Notopterygii, and temperature enters bladder, kidney channel, there is a scattered exterior cold, wind-damp dispelling,
The function in sharp joint, cure cold chill, headache and adiapneustia, wind-cold-dampness arthralgia, and item strengthening tendons are anxious, joint ache, geomantic omen edema, ulcer sore
Poison.It is to enter spleen, stomach, lung channel because of its nature and flavor sweet and neutral to select Radix Glycyrrhizae, is had and middle emergency, moistening lung, removing toxic substances, the work(of coordinating the drug actions of a prescription
Energy；Toast is used, and taste deficiency of food, abdominal pain loose stool, overstrain fever, consumptive lung disease cough, palpitaition , Jing Epilepsy are controlled；It is raw to use, abscess of throat is controlled, is digested
Property ulcer, carbuncle subcutaneous ulcer sore, antidote poison and food poisoning.It is to put down because its nature and flavor is pungent salty, enter liver, lung, stomach to select the larva of a silkworm with batrytis,
It expels endogenous wind to relieve convulsion, the function of reducing phlegm and resolving masses controls apoplectic aphasia , Jing Epilepsy, intermittent headache, sore-throat, larynx numbness, scrofula tuberculosis, wind sore urticaris, pellet
Poison, mastitis.Selecting scorpio is put down because its nature and flavor is salty pungent, toxic, enters meridian of Foot-JUE YIN, there is a wind-dispelling, relieving convulsion, dredging collateral, removing toxic substances
Function controls convulsion, insane Epilepsy, apoplexy, hemiplegia, deviation of the eye and mouth, migraine, arthralgia pain due to rheumatism, lockjaw, lymph junction
Core, rubella sore swells.
Specific implementation mode
The drug dose of instant component is also to be obtained by plenty of explorations of the inventor, and the dosage of each component is following heavy
All tools have a better effect in amount range：
Windproof 145-155 grams, 145-155 grams of schizonepeta, 145-155 grams of Fructus Forsythiae, 55-65 grams of Chinese ephedra, 235-245 grams of peppermint, asarum
25-35 grams, 115-125 grams of Rhizoma Chuanxiong, 115-125 grams of schizonepeta, windproof 40-50 grams, 55-65 grams of the root of Dahurain angelica, 55-65 grams of Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae
55-65 grams, 115-125 grams of the larva of a silkworm with batrytis, 25-35 grams of scorpio.
Preferably：
240 grams of peppermint, 30 grams of asarum, 120 grams of Rhizoma Chuanxiong, 120 grams of schizonepeta, windproof 45 grams, 60 grams of the root of Dahurain angelica, 60 grams of Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae 60
Gram, 120 grams of the larva of a silkworm with batrytis, 30 grams of scorpio.
The preparation method of drug of the present invention is as follows
One, it stocks up
1, peppermint：Pick net impurity, remove undesirable root, first by leaf tremble it is lower separately put, stem is then sprayed into clear water, rear segment is moisturized, dries,
Again with leaf and even；
2, asarum：Cleared impurity, is sprayed with water and is moistened, and timely segment is dried；
3, Rhizoma Chuanxiong：Impurity is picked, large and small is separated, is soaked in water, solarization is dried in the air, and is sliced after bored profit, dry；
4, schizonepeta：Net impurity is picked, is slightly steeped with water, is pulled segment out, dry；
5, windproof：Residual stem is removed, is soaked in water, is pulled out, slice is moisturized, dries；
6, the root of Dahurain angelica：Net impurity is picked, is eluted with water, is impregnated, is pulled out and moisturize, when slightly shining to crust without soapy feeling, then after bored profit, slice
It is dry；
7, Rhizoma Et Radix Notopterygii：Impurity is picked, cleans, moisturizes, is sliced, dries；
8, Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant it is saturating when, pull out, moisturize slice, dry；
9, the larva of a silkworm with batrytis：Silk hair is picked, dirt is cleaned, dries；
10, scorpio：Clear water floats the matter that desalts, and dries or low baking temperature roasting is used.
Two, it prepares
1, the peppermint of the weight, asarum, Rhizoma Chuanxiong, schizonepeta, the windproof, root of Dahurain angelica, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae, the larva of a silkworm with batrytis, scorpio are put into container
It is interior, grind into powder, making pellets by mixing medical powder with honey, per 1.5 grams of ball；
2, manufactured pill is put into spare in container.
Windproof in prescription to deliver, wind-dispelling, victory is wet, and the function of analgesic is monarch drug in a prescription；Schizonepeta is delivered, wind-dispelling, the work(of regulating blood condition
Energy；Rhizoma Chuanxiong has promote breath and open depression, dispels pathogenic wind and remove dampness, the function of promoting blood circulation and stopping pain, and the two is ministerial drug, and three taste medicines deliver wind-dispelling jointly,
Expel endogenous wind to relieve convulsion, promote breath and open depression dispel pathogenic wind and remove dampness, the effect of promoting blood circulation and stopping pain, and treatment migraine effect is comprehensive, and to deliver wind-dispelling, victory
Wet analgesic can effect a permanent cure based on promote breath and open depression, and scorpio has a wind-dispelling, relieving convulsion, dredging collateral, and the function of removing toxic substances is adjutant, Radix Glycyrrhizae have and in delay
Anxious, moistening lung, removing toxic substances, the function of coordinating the drug actions of a prescription is to make medicine, and all medicines are to take stopgap measures with being left.
Drug of the present invention, which has, delivers wind-dispelling, expel endogenous wind to relieve convulsion, and promote breath and open depression dispels pathogenic wind and remove dampness, and the function of promoting blood circulation and stopping pain is used for
Treat migraine, short treating period, quick, non-relapse after healing.
Carry out the advantageous effect of the present invention is further explained the drug below by way of test example, these test examples include this hair
The animal toxicity test report of bright drug and clinical observation on the therapeutic effect data.
The animal toxicity test of [test example 1] drug of the present invention is reported：
Rabbit 30, male and female dual-purpose, 2.0-2.5kg of weight is taken to be divided to two groups, every group 15, one of which is tested for overdose
Group, another group is normal amount test group.Super quantity group is 0.5 gram every every time, and normal amount is 0.25 gram every every time, gives prescription
Formula is dilution administration by gavage administration, twice daily, even served 7 days, the reaction of observation administration daily, the results showed that two groups of rabbit activities, drinks
Food is normal, and drug is without bad toxic side effect.
The clinical observation on the therapeutic effect of [test example 2] drug of the present invention
1, general information
Accept migraine out-patient totally 30 for medical treatment.
2, diagnostic criteria
Migraine clinic is main performance with ictal middle severe, the headache of beating sample, and headache is mostly inclined side, generally continues 4~72
Hour, it can aggravate to have a headache with Nausea and vomiting, light, Sound stimulat or daily routines.
3, therapy
Above-mentioned medicament is selected, is taken to patient, each taking 1 dose, each taking 3 balls, early daily, evening respectively takes 1 time, and 8 days are one
A course for the treatment of, continuously takes 4 course for the treatment of.
4, efficacy assessment standard
It is effective：Cephalagra disappears, and constitution restores normal, recovery from illness；
It improves：Cephalagra is clearly better, and Nausea and vomiting situation mitigates, and gradually restores normal；
In vain：Improvement standard person is not achieved.
5, treatment results（It see the table below）
In above-mentioned treatment, with drug therapy migraineur 30 of the present invention, as a result effective 24, obvious effective rate 80% improves
4, improvement rate 13.3%, invalid 2, total effective rate 93.3%.
Claims (3)
1. a kind of drug for treating migraine, it is characterised in that：It is made of the bulk pharmaceutical chemicals in following weight range：
235-245 grams of peppermint, 25-35 grams of asarum, 115-125 grams of Rhizoma Chuanxiong, 115-125 grams of schizonepeta, windproof 40-50 grams, root of Dahurain angelica 55-
65 grams, 55-65 grams of Rhizoma Et Radix Notopterygii, 55-65 grams of Radix Glycyrrhizae, 115-125 grams of the larva of a silkworm with batrytis, 25-35 grams of scorpio.
2. drug according to claim 1, wherein the dosage of each bulk pharmaceutical chemicals is：
240 grams of peppermint, 30 grams of asarum, 120 grams of Rhizoma Chuanxiong, 120 grams of schizonepeta, windproof 45 grams, 60 grams of the root of Dahurain angelica, 60 grams of Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae 60
Gram, 120 grams of the larva of a silkworm with batrytis, 30 grams of scorpio.
3. the preparation method of drug according to claim 1 or claim 2, it includes the following steps：
（One）Stock
（1）Peppermint：Pick net impurity, remove undesirable root, first by leaf tremble it is lower separately put, stem is then sprayed into clear water, moisturizes rear segment, solarization
It is dry, then with leaf and even；
（2）Asarum：Cleared impurity, is sprayed with water and is moistened, and timely segment is dried；
（3）Rhizoma Chuanxiong：Impurity is picked, large and small is separated, is soaked in water, solarization is dried in the air, and is sliced after bored profit, dry；
（4）Schizonepeta：Net impurity is picked, is slightly steeped with water, is pulled segment out, dry；
（5）It is windproof：Residual stem is removed, is soaked in water, is pulled out, slice is moisturized, dries；
（6）The root of Dahurain angelica：Net impurity is picked, is eluted with water, is impregnated, is pulled out and moisturize, when slightly shining to crust without soapy feeling, then after bored profit, cut
Piece is dried；
（7）Rhizoma Et Radix Notopterygii：Impurity is picked, cleans, moisturizes, is sliced, dries；
（8）Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant it is saturating when, pull out, moisturize slice, dry；
（9）The larva of a silkworm with batrytis：Silk hair is picked, dirt is cleaned, dries；
（10）Scorpio：Clear water floats the matter that desalts, and dries or low baking temperature roasting is used；
（Two）It prepares
（1）The peppermint of the weight, asarum, Rhizoma Chuanxiong, schizonepeta, the windproof, root of Dahurain angelica, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae, the larva of a silkworm with batrytis, scorpio are put into appearance
In device, grind into powder, making pellets by mixing medical powder with honey, per 1.5 grams of ball；
（2）Manufactured pill is put into spare in container.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810409447.2A CN108403762A (en) | 2018-05-02 | 2018-05-02 | A kind of drug and preparation method thereof for treating migraine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810409447.2A CN108403762A (en) | 2018-05-02 | 2018-05-02 | A kind of drug and preparation method thereof for treating migraine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108403762A true CN108403762A (en) | 2018-08-17 |
Family
ID=63137358
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810409447.2A Withdrawn CN108403762A (en) | 2018-05-02 | 2018-05-02 | A kind of drug and preparation method thereof for treating migraine |
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| Country | Link |
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| CN (1) | CN108403762A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111150772A (en) * | 2018-10-22 | 2020-05-15 | 广西小咕噜生物科技有限公司 | External traditional Chinese medicine ointment for treating migraine |
-
2018
- 2018-05-02 CN CN201810409447.2A patent/CN108403762A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111150772A (en) * | 2018-10-22 | 2020-05-15 | 广西小咕噜生物科技有限公司 | External traditional Chinese medicine ointment for treating migraine |
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