CN109223971A

CN109223971A - A kind of instant particles as Chinese medicine and preparation method thereof for treating allergic bronchopulmonary aspergillosis

Info

Publication number: CN109223971A
Application number: CN201811368940.0A
Authority: CN
Inventors: 张淼
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-11-17
Filing date: 2018-11-17
Publication date: 2019-01-18

Abstract

The invention discloses a kind of instant particles as Chinese medicine and preparation method thereof for treating allergic bronchopulmonary aspergillosis, belong to the field of Chinese medicines.The raw material of effective ingredient of the present invention forms are as follows: Chinese yam, radix pseudostellariae, cuneate lespedeza herb with root, Radix Ophiopogonis, perny false fairybells rhizome, the root of straight ladybell, purpleback murdannia herb, Radix Glycyrrhizae, dandelion, waxgourd seed, tussilago, dark plum, semen brassicae, Chinese gall, radices trichosanthis, Chinese ephedra, fruit of negundo, the larva of a silkworm with batrytis, sponge gourd flower, gekko.The present invention selects medicinal material to meet a monarch and his subjects left side and is allowed to manage, it suits the remedy to the case for the cause of disease, have tonifying speen and tonifying kidney tonifying lung, nourishing Yin and promoting production of body fluid, moistening lung for removing phlegm, freeing lung and relieving asthma, astringe the lung to stop cough, is clearing heat and detoxicating, inducing sweat and dispelling exogenous evils, expelling wind and relieving convulsion, detumescence and apocenosis the effect of, good absorption effect, it is significant in efficacy, it is higher to allergic bronchopulmonary aspergillosis cure rate according to clinical verification.

Description

A kind of instant particles as Chinese medicine and preparation method thereof for treating allergic bronchopulmonary aspergillosis

Technical field

The present invention relates to the field of Chinese medicines more particularly to a kind of instant particles as Chinese medicine for treating allergic bronchopulmonary aspergillosis and its Preparation method.

Background technique

Allergic bronchopulmonary aspergillosis refers to the allergy that alveolar, interstitial lung and bronchus generate Aspergillus specific antigen Inflammation, the disease are often betided with chronic asthma or pulmonary cystic fibrosis patient, are one of eosinophils pneumonia.In recent years Come, with the exacerbation of atmosphere pollution, this disease disease incidence has the trend of growth.Allergic bronchopulmonary aspergillosis clinical manifestation: one As occur on the basis of idiocrasy constitution, wheeze, generate heat in repeated relapsing, coughing, expectoration brown phlegm bolt, hemoptysis.Physical examination two Lung is covered with wheezing sound, and lung infiltrating sites have fine crackles.Modern medicine thinks that the cause of disease of allergic bronchopulmonary aspergillosis is cigarette Aspergillus often colonizes in human upper airway, when body immunity reduces, or because occupational factor inhales National People's Congress's amount aspergillus spore for a long time, It after respiratory tract infection, aspergillus spore can be caused to be inhaled into, rests in the bronchus of segment, under body temperature, spore is in branch gas Growth and breeding in pipe secretion, constantly fall off mycelia antigen, leads to a series of immune response, cause bronchial wall damage and The infiltration of eosinophils lung.Bronchitis caused by the damage of bronchial wall and Fungi infection is different, because with various sides Method dyeing, which is checked, not can prove that there is mycelia intrusion in bronchial wall and pulmonary parenchyma, so its lesion category immune injury. When allergic bronchopulmonary aspergillosis patient's western medical treatment, transtracheal instills or the antifungals such as Neulized inhalation amphomoronal, though There is certain curative effect to aspergillus in bronchus is eliminated, but easy to recur；Oral glucocorticoid is the choice drug for treating this disease, can be subtracted Few lung's infiltration, controls bronchospasm symptoms, reduces amount of expectoration, but oral glucocorticoid treatment cycle is longer, take for a long time, It can cause metabolism and water and salt metabolic disturbance, the adverse reactions such as the hyperfunction syndrome of class adrenal cortex function occur.Doctor trained in Western medicine is controlled Treatment can only treat the symptoms and cannot effect a permanent cure, easy to recur, and compare doctor trained in Western medicine, and the general side effect of Chinese traditional treatment is smaller, can enhance patient itself Immune function, treating both manifestation and root cause of disease have certain advantage.Prescription to the ill there is no without being expressly recited to this disease in TCM Document, according to The clinical symptoms of this disease, it is considered herein that lung does not hurt not cough, spleen does not hurt not chronic cough, and kidney, which is not hurt, not to be breathed heavily, though the sick place of this disease is main It shows bronchus, but sick position is dirty in lung, spleen, kidney three, so treatment is started with from lung spleen kidney, there is tonifying speen and tonifying kidney tonifying lung, support Yin and promoting production of body liquid, moistening lung for removing phlegm, freeing lung and relieving asthma, astringe the lung to stop cough, is clearing heat and detoxicating, inducing sweat and dispelling exogenous evils, expelling wind and relieving convulsion, detumescence and apocenosis the effect of, Treating both manifestation and root cause of disease is focused on while eliminating surface symptoms to the internal cause for causing disease, i.e. human body body spleen, kidney, lung function Conditioning and recovery treatment, improve patient itself immune function, good absorption effect is significant in efficacy, according to clinical verification to change Answering property bronchopulmonary aspergillosis cure rate is higher.

Summary of the invention

The present invention provides a kind of instant particles as Chinese medicine and preparation method thereof for treating allergic bronchopulmonary aspergillosis, have strong Spleen and tonifying kidney tonifying lung nourishing Yin and promoting production of body fluid, moistening lung for removing phlegm, freeings lung and relieving asthma, astringes the lung to stop cough, is clearing heat and detoxicating, inducing sweat and dispelling exogenous evils, expelling wind and relieving convulsion, disappearing It the effect of swollen apocenosis, cures the disease and seeks source treating both manifestation and root cause of disease, allergic bronchopulmonary aspergillosis caused by a variety of causes is all had very well Curative effect.

To achieve the above object, technical solution of the present invention is implemented as follows:

A kind of instant particles as Chinese medicine for treating allergic bronchopulmonary aspergillosis, be made the effective ingredient raw material composition and again Measure number are as follows:

15~30 parts of Chinese yam, 15~30 parts of radix pseudostellariae, 15~30 parts of cuneate lespedeza herb with root, 15~30 parts of Radix Ophiopogonis,

15~30 parts of perny false fairybells rhizome, 10~25 parts of the root of straight ladybell, 10~25 parts of purpleback murdannia herb, 10~25 parts of Radix Glycyrrhizae,

9~20 parts of dandelion, 9~20 parts of waxgourd seed, 9~20 parts of tussilago, 9~20 parts of dark plum,

9~20 parts of semen brassicae, 6~15 parts of Chinese gall, 6~15 parts of radices trichosanthis, 6~15 parts of Chinese ephedra,

3~12 parts of fruit of negundo, 3~12 parts of the larva of a silkworm with batrytis, 1~9 part of sponge gourd flower, 1~9 part of gekko.

The raw material composition and parts by weight of the effective ingredient is made are as follows:

18~26 parts of Chinese yam, 18~26 parts of radix pseudostellariae, 18~26 parts of cuneate lespedeza herb with root, 18~26 parts of Radix Ophiopogonis,

18~26 parts of perny false fairybells rhizome, 15~21 parts of the root of straight ladybell, 15~21 parts of purpleback murdannia herb, 15~21 parts of Radix Glycyrrhizae,

12~18 parts of dandelion, 12~18 parts of waxgourd seed, 12~18 parts of tussilago, 12~18 parts of dark plum,

12~18 parts of semen brassicae, 8~12 parts of Chinese gall, 8~12 parts of radices trichosanthis, 8~12 parts of Chinese ephedra,

5~10 parts of fruit of negundo, 5~10 parts of the larva of a silkworm with batrytis, 2~7 parts of sponge gourd flower, 1~6 part of gekko.

25 parts of Chinese yam, 25 parts of radix pseudostellariae, 24 parts of cuneate lespedeza herb with root, 24 parts of Radix Ophiopogonis,

20 parts of perny false fairybells rhizome, 20 parts of the root of straight ladybell, 18 parts of purpleback murdannia herb, 18 parts of Radix Glycyrrhizae,

15 parts of dandelion, 15 parts of waxgourd seed, 15 parts of tussilago, 15 parts of dark plum,

15 parts of semen brassicae, 10 parts of Chinese gall, 10 parts of radices trichosanthis, 10 parts of Chinese ephedra,

8 parts of fruit of negundo, 8 parts of the larva of a silkworm with batrytis, 5 parts of sponge gourd flower, 3 parts of gekko.

A kind of preparation of instant particles as Chinese medicine for treating allergic bronchopulmonary aspergillosis of any of claims 1-3 Method comprises the following steps that:

(1) by Chinese yam, radix pseudostellariae, cuneate lespedeza herb with root, Radix Ophiopogonis, the root of straight ladybell, purpleback murdannia herb, dandelion, waxgourd seed, tussilago, dark plum, sinapsis alba Son, Chinese gall, radices trichosanthis, fruit of negundo, the larva of a silkworm with batrytis, sponge gourd flower, gekko are cleaned and are put into container, and the 8-10 times of distilled water measured is added It impregnates 4-5 hours, heating is boiled 3-4 hours, and immersion liquid is extracted；The 6-8 times of distilled water measured is added again, heating is boiled 2-3 hours, Extract immersion liquid；The 4-6 times of distilled water measured finally is added, heating is boiled 1-2 hours, and immersion liquid is extracted；Merge immersion liquid three times, mistake Filter, it is spare to obtain filtrate；

(2) perny false fairybells rhizome is cleaned and is put into container, the ethanol solution of the concentration 80% of 4 times of amounts is added, impregnated 1-2 hours, heat back Stream extracts 3-4 hours, and it is spare to obtain filtrate for filtering；

(3) net licorice tablet is taken, cooked honey and a little boiled water is added, it is slightly bored after mixing thoroughly, it sets in frying container, is fried with slow fire depth Yellow is taken out when tack-free, cools, and crushing is ground, and crosses 120 mesh dusting covers, obtains fine powder, spare；

(4) refined honey is taken, certain amount of boiling water is added to dilute, drenches in Chinese ephedra section and mixes thoroughly, bored profit is set in frying container, heated with mild fire, fries When extremely tack-free, taking-up is cooled down, and crushing is ground, and is crossed 120 mesh dusting covers, is obtained fine powder, spare；

(5) it by step (1), step (2) resulting filtrate, is mixed with fine powder obtained in step (3), step (4), adds auxiliary material sugarcane Sugar and dextrin, which are uniformly mixed, is made particle, after dry, whole grain, is packaged into the instant particles as Chinese medicine of every bag of 3g.

The property of medicine of Chinese medicine is as follows:

Chinese yam: sweet in flavor；It is mild-natured.Enter lung；Spleen；Kidney channel.Tonifying spleen；Support lung；It reinforces the kidney；Strengthening the essence.Cure mainly splenasthenic diarrhea；Deficiency of food edema；Lung Empty cough and asthma；It quenches one's thirst；Spermatorrhea；Leukorrhagia；Kidney deficiency frequent micturition；Carbuncle swells are controlled in external application；Scrofula." book on Chinese herbal medicine is just " carries: " Chinese yam, energy invigorating the spleen qi-restoratives, grows Essence is reinforced the kidney, and weakness is controlled, and treats general debility." modern medical studies have confirmed that Chinese yam can reduce blood glucose, body is adjusted to non-spy Different stimulate the reaction effectively antagonizes the inhibition immunization of cyclophosphamide, stimulates intestinal motility, promotes intestinal contents emptying, It furthermore can also aid digestion, antidiarrheal, eliminating the phlegm.

Radix pseudostellariae: sweet in flavor;Slight bitter；Cold nature.Returns spleen, lung channel.Help spleen and lung；Nourishing generate fluid.It cures mainly weakness of the spleen and the stomach；Appetite It is depressed；Lassitude；Impairment of both QI and YIN；Dry cough phlegm is few；Spontaneous perspiration shortness of breath；And the convalescent stage of febrile disease deficiency of vital energy saliva wound；Interior heat is thirsty；Or nerve It is weak, palpitation and insomnia, dizzy amnesia, Infantile Summer Fever." Shaanxi Chinese herbal medicine ": invigorating qi and benefiting blood, invigorating the spleen are promoted the production of body fluid.It is physically weak after curing the disease, Cough due to deficiency of the lung, insufficiency of the spleen diarrhoea, children's abnormal sweating, palpitaition, dry, do not feel like eating.Modern medicine study proves: radix pseudostellariae has body There are adaptive significances, body can be enhanced to the defence capability of various destructive stimulus, can also enhance the intracorporal metabolism of people.

Cuneate lespedeza herb with root: bitter, puckery, cool in nature.Return lung；Liver；Kidney channel.Kidney tonifying arresting seminal emission；Invigorating spleen to remove dampness；Preventing phlegm from forming and stopping coughing；It is clearing heat and detoxicating. Cure mainly kidney deficiency；Spermatorrhea；The enuresis；Frequent micturition；Gonorrhoea；Leukorrhagia；Diarrhea；Dysentery；Oedema；Infantile malnutrition；Cough and asthma；Traumatic injury； Red eye, swell pain；Ulcerative carbuncle pyogenic infections；Insect-bite." Traditional Chinese Medicine in Sichuan will ": the weak enuresis, man's gonorrhoea, woman leukorrhea, deficiency of Yin gas are controlled Weak, promoting lactation treats infantile malnutrition due to digestive disturbances or intestinalparasites disease.Modern study proves that: cuneate lespedeza herb with root has the effects that cough-relieving, eliminating the phlegm, relievings asthma, antibacterial, has choosing to uterus Select sexual excitement effect.

Radix Ophiopogonis: sweet in flavor；Slight bitter；Cold nature.Return heart；Lung；Stomach meridian.Nourishing Yin and promoting production of body fluid；Moistening lung and clearing away the heart-fire.Dryness of the lung dry cough is cured mainly, yin Consumptive disease is coughed, larynx numbness pharyngalgia, injury thirst, Heat Diabetes, vexed insomnia, dry constipation of intestines." Mingyi Bielu " carries: " Radix Ophiopogonis treats body weight Mesh is yellow, and rami cardiaci inferiores is full, and consumptive disease visitor's heat, dry polydipsia, anti-nausea, more impotence are fallen, and strong yin strengthening the essence, disappear Gu Tiaozhong, protects mind, determines lung qi, Five viscera settling makes us fertile strong." modern medical studies have confirmed that Radix Ophiopogonis contains, there are many steroid saponin, carrotene, mucilaginous substance, carbohydrate, beans The ingredients such as sterol have increasing leukocyte, and extending antibody, there are the effects of time, while improving immune function and nucleic acid synthetic ratio, The generation for promoting the immune substances such as antibody, complement, interferon, lysozyme has enhancing healthy tendency, reinforces anti-evil effect.

Perny false fairybells rhizome: sweet in flavor；It is mild-natured.It replenishes qi to invigorate the spleen；Yin nourishing and lung moistening；It activates blood and relax tendons.Cure mainly puerperal asthenia；Infantile malnutrition；Yin Void cough；Hidrosis；Dry；Treating swelling and pain by traumatic injury；Rheumatalgia pain；Pain in the loins." Guizhou herbal medicine ": Yin nourishing and lung moistening promotes the production of body fluid to quench thirst.

The root of straight ladybell: sweet in flavor；Slight bitter；Cold nature.Return lung；Stomach meridian.Nourishing yin and clearing heat；Moistening lung for removing phlegm；Reinforcing stomach reg fluid.It is long to cure mainly the deficiency of Yin Cough；Consumptive disease is coughed phlegm blood；Cough caused by dryness phlegm is few；Abnormal heat sore throat；Injury thirst.Compendium of Material Medica carries: " the root of straight ladybell is sweet light and cold, and body is gently empty, specially Tonifying lung gas, thus beneficial spleen and kidney, thus gold can by fiery gram person preferably it.Yang-tonifying and give birth to yin, tonifying yin and sun processed must debate." existing It is confirmed for medical research, the root of straight ladybell contains each sterol of volatile oil, cumarin, starch, alkaloid, triterpenic acid, stigmasterol, β-, improves T Cell ratio improves lymphocyte transformation rate, and increasing leukocyte enhances macrophage function, extends antibody there are the time, there is solution Heat, analgesia, eliminating the phlegm, function of relievining asthma, enhance body fluid and cell immune function, to irritability and drug gastric ulcer have protection and Inhibiting effect.

Purpleback murdannia herb: sweet in flavor；Slight bitter；It is mild-natured.Clearing lung and relieving cough；Invigorating the lung and the kidney；Regulating menstruation, hemostasis.Cure mainly cough with lung heat；Dyspnea due to deficiency of vital energy Cough；Dizziness and tinnitus；Fracture；It spits blood." the civil common herbal medicine in Kunming ": root: tonifying lung kidney, antibechic.Control deficiency of vital energy dizziness and tinnitus, empty cough.

Radix Glycyrrhizae: sweet in flavor；It is mild-natured.Return heart；Lung；Spleen；Stomach meridian.It invigorates the spleen and benefits qi；It is clearing heat and detoxicating；Expelling phlegm and arresting coughing；Relieving spasm to stop pain；It adjusts With all medicines.It cures mainly weakness of the spleen and the stomach；Fatigue and weakness；Shortness of breath and palpitation；Coughing with a lot of sputum；Stomach duct and abdomen four limbs contraction；Carbuncle sore tumefacting virus；Alleviate Drug toxicity.Compendium of Material Medica carries: " Radix Glycyrrhizae is monarch in all medicines.72 kinds of mammary calculus poison are controlled, draft is malicious by every means for solution 1,002, adjusts With it is active from medicine." modern medical studies have confirmed that Radix Glycyrrhizae has stronger detoxication, there are also antiulcer, anti-inflammatory, antispastic antibechic, Lowering blood pressure and blood fat, antitumaous effect are widely used in treatment sphagitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis Etc. diseases, additionally have anti-gastric-ulcer, gastritis effect.

Dandelion: bitter；It is sweet；It is cold in nature.Return liver；Stomach meridian.It is clearing heat and detoxicating；Carbuncle that disappears dissipating bind.Cure mainly acute mastitis；Pulmonary abscess；Acute appendicitis；Zha The cheek；Boil poisonous soreness；Red eye, swell pain；Cold, fever；Cough；Abscess of throat；Stomach fire；Enteritis；Dysentery；Hepatitis；Cholecystitis；Urinary tract sense Dye；Snakebite and bugbite." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " controlling all pyogenic infections from tumour or sore, ruined tinea sore；Wind-dispelling, disappear all sores, dissipates scrofula tuberculosis；Only urine Blood controls the five leaching retention of urines, sharp bladder." clinic study shows that dandelion preparation can make to a certain extent instead of antibiotic With the effect of showing broad-spectrum antibiotic to certain diseases, there is certain antiviral functions.

Waxgourd seed: sweet in flavor；Cold nature.Enter lung；Large intestine channel.Clearing lung and eliminating phlegm；The carbuncle that disappears apocenosis；Dampness removing.Cure mainly phlegm-heat cough；Lung Carbuncle；Acute appendicitis；Gonorrhoea；Leukorrhagia；Tinea pedis；Oedema；Stranguria." book on Chinese herbal medicine states hook member " carries: " knot is poly- in main abdomen, ulceration purulence blood, in all stomach Stop up, the most key medicine." medicine clinical research shows that waxgourd seed has significant immunologic enhancement, there is apparent suppression to trypsase Production is used.

Tussilago: acrid flavour；Micro-sweet；It is warm-natured.It is distributed in lung channel.Moistening lung to lower qi；Preventing phlegm from forming and stopping coughing.New chronic cough is cured mainly to cough；Asthma；Overstrain cough Hemoptysis." haigoushen " carries: " main the treatments lung qi heart promotees, anxious hot weary labor, and cough connects without cease, and tears saliva is sticky.Control consumptive lung disease lung carbuncle pyemesis." modern Medical research confirms that tussilago has apparent antibechic, eliminating the phlegm and antiasthmatic effect, can improve the excitement levels of respiratory system, small to blood Platelet aggregation caused by plate activation factor has inhibiting effect, there is bronchorelaxing activity.

Dark plum: sour；It is mild-natured.Enter liver；Spleen；Lung；Kidney；Stomach；Large intestine channel.It astringes the lung to stop cough；Relieving diarrhea with astringents；Hemostasis；It promotes the production of body fluid；Peace Ascarid.Cure mainly chronic cough；Abnormal heat polydipsia；Chronic malaria；Chronic diarrhea；Dysentery；Hematochezia；Hematuria；Metrorrhagia；Ascariasis of biliary tract abdominal pain；Vomiting；Hookworm disease." guiding principle Mesh " it carries: " the puckery intestines of astringing lung-QI, control and cough long, and dysentery, gastric disorder causing nausea is dysphagic, and the ascariasis of biliary tract spits benefit, detumescence, gush phlegm, desinsection, solution ichthyotoxin, horse sweat poison, sulphur Pornography and drug." modern medical studies have confirmed that dark plum has apparent antibacterial action, to shigella dysenteriae, Pseudomonas aeruginosa, typhoid bacillus, large intestine Bacillus, tubercle bacillus, proteus, staphylococcus aureus, messy vibrios and various fungies have inhibiting effect, and can stimulate The hormonal secretion of the parotid gland, clearization blood enhance metabolic function.

Semen brassicae: acrid flavour；It is warm-natured.Enter lung；Liver；Spleen；Stomach；Pericardium channel.It reduces phlegm and avoid drink；Mass dissipating and swelling eliminating.Cure mainly cough and phlegm； Fullness in the chest and hypochondriac pain；Extremity numbness；Painful swelling of joints；Multiple abscess with damp phlegm；Negative subcutaneous ulcer pyogenic infections." detailed outline " carries: " promoting circulation of qi and eliminating phlegm；Except in cold warm up；It dissipates swollen Analgesic.Asthma is controlled to cough gastric disorder causing nausea；Numbness wood tinea pedis；The all pains of muscles and bones waist section." modern medical studies have confirmed that semen brassicae have significant anti-irritant, Antibacterial action increases bronchial secretion activity, eliminating the phlegm.

Chinese gall: sour；It is puckery；It is cold in nature.Enter lung；Stomach；Large intestine；Liver；Kidney channel.Astringing lung-QI；Hidroschesis；Puckery intestines；Controlling nocturnal emission with astringent drugs；Hemostasis；Solution Poison.Cure mainly chronic cough of deficiency lung；Spontaneous sweating；Protracted dysentery chronic diarrhea；Rectal prolapse；Spermatorrhea；Gonorrhoea；Various bleedings；Carbuncle swells boil." detailed outline " carries: " astringing lung-QI fall fire, resolving sputum drink, cough-relieving cough, quench one's thirst, night sweat, vomiting, blood loss, protracted dysentery, jaundice, pain in the chest and abdomen, and it is red to control eye for nocturnal fretfulness in infants Wet rotten, detumescence poison, sore throat hold back routed sore, metal-inflicted wound, receive under rectal prolapse, sub- intestines pendant." modern medical studies have confirmed that tan contained by Chinese gall Acid has precipitation to protein, shrinks thin vessels, to staphylococcus aureus, streptococcus, pneumococcus and typhoid fever, secondary wound Cold, dysentery, anthrax, Pseudomonas aeruginosa have apparent antibacterial or bactericidal effect, can be with many heavy metal ion, alkaloid and glucoside Insoluble compound is formed, can be used as antidote.

Radices trichosanthis: sweet in flavor；Slight bitter；Cold nature.Return lung；Stomach meridian.Clearing heat and promoting fluid；Moistening lung for removing phlegm；Detumescence and apocenosis.Cure mainly pyreticosis It is thirsty；It quenches one's thirst and drinks more；Lung-heat type cough；Sore swollen toxin." this is through meeting original " carries: " dropping hot phlegm on diaphragm, polydipsia in the minds of profit, disease is mad when removing Heat, the wet Huang of wine of dispelling illness, controls large carbuncle removing toxic substances apocenosis." modern medical studies have confirmed that radices trichosanthis is rich in trichosanthin, there is immune thorn Swash and immunosuppressive action, suppressing virus replication procreation reduce the viable count being infected by the virus in immunocyte, can reduce blood Sugared activity, there is certain inhibiting effect to hemolytic streptococcus, Diplococcus pneumopniae, corynebacterium diphtheriae.

Chinese ephedra: acrid flavour；Slight bitter；It is warm-natured.Return lung；Bladder meridian.Inducing sweat and dispelling exogenous evils；It freeings lung and relieving asthma；Inducing diuresis for removing edema.Cure mainly chill table Real example；Fever with aversion to cold；It is lossless；Body of having a headache aches；Heresy is stopped up in lung；Lung Qi obstruction；Cough and asthma；Edema caused by wind；Difficult urination；Rheumatism numbness Bitterly；Skin numbness and rubella itch；Negative subcutaneous ulcer subcutaneous nodule.Shennong's Herbal carries: " main apoplexy, cold headache, a kind of malaria.Perspiration is delivered, is uncharmed Hot gas, only cough with dyspnea, removes fever and chills, breaks hard accumulation." modern medicine study shows that ephedrine contained by Chinese ephedra can play indirectly The adrenergic effect of class enhances myocardial contractive power, expands coronary artery, brain, muscle vascular, shrinks the internal organ such as kidney, spleen and skin, glues Film blood vessel increases blood pressure, loose bronchus and gastrointestinal smooth muscle, increases the tension of trigonumvesicae flesh and sphincter, can make tired The skeletal muscle tensity of labor is significant and enduringly increases, and in addition there are sweating and heat resolving, antibacterial, antiviral, antiallergy, immune, towns Cough is relievingd asthma, eliminating the phlegm, diuresis.

Fruit of negundo: acrid flavour；It is bitter；It is warm-natured.Return lung；Stomach；Liver Channel.It expels pathogenic wind from the body surface；It is relieving cough and asthma；Qi-regulating helps digestion analgesic.It cures mainly Cold；Cough；Asthma；Stomachache acid regurgitation；Indigestion；Dyspepsia dysentery；Cholecystitis；Gall stone；Hernia." Guangzhou flora " Carry: " phlegm, antibechic are washed in fruit of negundo wind-dispelling." modern medical studies have confirmed that fruit of negundo decoction has expansion to make bronchial smooth muscle With trachea-bronchial epithelial cell spasm can be released."

The larva of a silkworm with batrytis: acrid flavour；It is salty；It is mild-natured.Return liver；Lung；Stomach meridian.Expelling wind and relieving convulsion；Reducing phlegm and resolving masses；Removing toxic substances relieving sore-throat.The major functions: frightened epilepsy is taken out It jerks；Apoplexy facial paralysis；Migraine and general headache；Abscess of throat；Scrofula；Mumps；Rubeola；Sore." haigoushen ": " solar corona ", Su Song, Element all takes its property to belong to sun, and wind-heat is yang pathogens, can enter skin channels and collaterals, dissipates all heat symptoms caused by an exopathgen gas.

Sponge gourd flower: sweet in flavor；Slight bitter；It is cold in nature.It is clearing heat and detoxicating；Preventing phlegm from forming and stopping coughing.Cure mainly cough with lung heat；Pharyngalgia；Nasosinusitis；Furunculosis Pyogenic infections；Hemorrhoid." the southern regions of the Yunnan Province book on Chinese herbal medicine ": clearing lung-heat heat, gas under dissolving phlegm, cough-relieving, only throat aches, and disappear polydipsia, reducing the minister-fire.

Gekko: taste is salty；It is mild-natured.Return lung；Kidney channel.Kidney-nourishing tonifying lung；Stoping asthma and cough.The major functions: deficiency of both the lung and kidney asthma and cough, consumptive disease Cough；Hemoptysis；Impotence due to deficiency of the kidney；Spermatorrhea；Frequent urination；It quenches one's thirst." detailed outline ": tonifying lung gas, benefiting essence-blood, stoping asthma and cough treat pulmonary abscess and disappear Yearningly, supporing yang road.Modern medicine study shows: gekko alcohol extract has apparent antiasthmatic effect to asthma caused by acetylcholine, to from Body tracheae also has direct relexation.

Compared with the prior art, the present invention has the following beneficial effects:

It is mutually auxiliary that the present invention selects the pharmacological property of medicinal material mutually to fit, and suits the remedy to the case for the cause of disease, there is tonifying speen and tonifying kidney tonifying lung, nourishing Yin and promoting production of body fluid, profit Lung resolving sputum, freeing lung and relieving asthma, astringe the lung to stop cough, is clearing heat and detoxicating, inducing sweat and dispelling exogenous evils, expelling wind and relieving convulsion, detumescence and apocenosis the effect of, assimilation effect It is good, it is significant in efficacy, it is higher to allergic bronchopulmonary aspergillosis cure rate according to clinical verification.

Specific embodiment

Present invention is further elaborated in following combination specific embodiment.

Embodiment 1

The raw material of effective ingredient of the present invention forms and weight are as follows:

The processing step of process for preparing medicine of the present invention are as follows:

Usage and dosage: oral, 1 bag every time, 3 times a day, half an hour is taken after mixing it with water after meal with boiled water, and 14 days are 1 course for the treatment of.

Embodiment 2

The process for preparing medicine processing step and usage and dosage of the present embodiment are same as Example 1.

Embodiment 3

Clinical data:

1, case selection

37 clinical observations of allergic bronchopulmonary aspergillosis patient that selection our hospital or outer court make a definite diagnosis, patient are randomly divided into two Group.Treatment group 18, wherein male 11, women 7, the age 17~56 years old, average age 37.6 years old.Control group 19, Middle male 14, women 5, the age 16~55 years old, average age 38.3 years old.Two groups of qualifications are almost the same, no significant difference, tool There is comparativity.

2, treatment method

Treatment group patient takes drug of the present invention, takes orally, 1 bag every time, 3 times a day, half an hour is taken after mixing it with water after meal with boiled water, is within 14 days 1 course for the treatment of, takes 3 course for the treatment of.

Control group gives amphomoronal atomization respectively and inhales according to the symptom for the allergic bronchopulmonary aspergillosis being diagnosed to be Enter, Itraconazole oral solution, takes orally the western medicine routine treatments means such as prednisone.

3, efficacy determination:

(1) fully recover: cough, expectoration, asthma, it is uncomfortable in chest, pharynx itch the general malaises clinical symptoms such as dry, sign disappearance；

(2) improve: cough, expectoration, asthma, uncomfortable in chest, to swallow general malaises clinical symptoms such as dry of itching substantially reduced.

(3) invalid: symptom is same to treat preceding no significant difference.

4, result

10 are cured in treatment group, are improved 5, invalid 3, cure rate 55.6%, total effective rate 83.3%.

7 are cured in control group, are improved 6, invalid 6, cure rate 36.8%, total effective rate 68.4%.

The above results show that the cure rate and total effective rate for the treatment of group are apparently higher than control group.

Typical case citing:

1, old ××, male, 37 years old.Patient cough, cough brown mucus phlegm, interruption fever six months, carry out institute's interrogation, through examining It looks into, chest CT shows double upper lungs and lower-left lung patch shape infiltration shadow, with bronchiectasis and mediastinal lymph node enlargement, including aspergillus fumigatus Multinomial anaphylactogen skin test positive inside, aspergillus fumigatus specific IgE 67.8kUA/L, lesion puncturing tissue culture have aspergillus fumigatus raw It is long, it is diagnosed as allergic bronchopulmonary aspergillosis, after being taken 3 courses for the treatment of of Chinese medicine of the present invention, above-mentioned symptom is completely disappeared, It has fully recovered.

2, neat ××, female, 48 years old.Patient's chest distress, wheezes, and expectoration does not go out, and phlegm white carrys out institute's interrogation, on inspection, There is intrapulmonary infiltration shadow repeatedly in chest x-ray or CT, and double upper lungs are to write, and in migrans, double lungs are dispersed in wheezing sound, with centre type branch gas Enlargement of pipe, Skin photosensitization test aspergillus fumigatus are positive anaphylactic type dermoreaction, aspergillus fumigatus specific IgE 67.3kUA/L, and cigarette is bent Bacterium specificity ige antibody positive, lesion puncturing tissue culture have aspergillus fumigatus growth, are diagnosed as allergic bronchopulmonary aspergillosis, After being taken 3 courses for the treatment of of Chinese medicine of the present invention, above-mentioned symptom is completely disappeared, and has fully recovered.

Allergic bronchopulmonary aspergillosis is that human body causes to intrabronchial aspergillus antigen generation allergy is parasitized A kind of disease.Its lesion category immune injury.Chinese medicine of the present invention is suited the remedy to the case according to the cause of disease, radix pseudostellariae, perny false fairybells rhizome, wheat in side Winter, purpleback murdannia herb, gekko, Chinese yam can strengthening the spleen and replenishing qi, kidney-nourishing tonifying lung, nourishing Yin and promoting production of body fluid, stoping asthma and cough；Chinese gall, dark plum can be held back in side Lung cough-relieving, hemostasis；The root of straight ladybell, radices trichosanthis can nourishing yin and clearing heat, moistening lung for removing phlegm in side；Dandelion can be clearing heat and detoxicating in side；Fang Zhongbai is stiff Silkworm, semen brassicae can expelling wind and relieving convulsion, reducing phlegm and resolving masses, removing toxic substances relieving sore-throats；Waxgourd seed can clearing lung and eliminating phlegm, the carbuncle that disappears apocenosis, dampness removing in side；Fang Zhong Tussilago, sponge gourd flower, cuneate lespedeza herb with root can clearing heat and detoxicating, moistening lung to lower qi, invigorating spleen to remove dampness, preventing phlegm from forming and stopping coughing；Square epheday intermedia can inducing sweat and dispelling exogenous evils, It freeings lung and relieving asthma；Fruit of negundo can expel pathogenic wind from the body surface, is relieving cough and asthma in side；Radix Glycyrrhizae can expelling phlegm and arresting coughing, coordinating the drug actions of a prescription in side；All medicines close in side With can play tonifying speen and tonifying kidney tonifying lung altogether, nourishing Yin and promoting production of body fluid, moistening lung for removing phlegm, freeing lung and relieving asthma, astringe the lung to stop cough, clearing heat and detoxicating, inducing sweat and dispelling exogenous evils, dispel The effect of wind relieving convulsion, detumescence and apocenosis, treating both manifestation and root cause of disease are focused on while eliminating surface symptoms to the internal cause for causing disease, i.e. people Body body spleen, kidney, the conditioning of lung function and recovery treatment, improve patient itself immune function, modern pharmacological research Also indicate that: square epheday intermedia has antiallergic action, inhibits inflammatory cell release inflammatory mediator, antibacterial, antiviral, antiallergy, enhancing Immune effect；Radix pseudostellariae can enhance body to the defence capability of various destructive stimulus in side, can also enhance the intracorporal substance of people Metabolism；Radix Ophiopogonis, the root of straight ladybell, waxgourd seed can improve immune function in side；Chinese yam is adjustable body to non-specific stimulate the reaction in side； Dandelion, Chinese gall, dark plum have certain antiviral functions in side, have apparent antibacterial or bactericidal effect for fungi；Side Middle radices trichosanthis has immunostimulation and immunosuppressive action, and suppressing virus replication is multiplied, and is infected by the virus in reduction immunocyte The effect of viable count；Semen brassicae has significant anti-irritant, antibacterial action in side, increases bronchial secretion activity, eliminating the phlegm；Fang Zhong Tussilago has apparent antibechic, eliminating the phlegm and antiasthmatic effect, can improve the excitement levels of respiratory system, there is bronchorelaxing activity；Side Middle cuneate lespedeza herb with root has the effects that cough-relieving, eliminating the phlegm, relievings asthma, antibacterial；Fruit of negundo decoction has dilating effect to bronchial smooth muscle in side, Trachea-bronchial epithelial cell spasm can be released；Patient's immunity is adjusted in all medicines share in side, inhibits allergy, and good absorption effect is treated Effect is significant, higher to allergic bronchopulmonary aspergillosis cure rate according to clinical verification.

Claims

1. a kind of instant particles as Chinese medicine for treating allergic bronchopulmonary aspergillosis, which is characterized in that the effective ingredient is made Raw material composition and parts by weight are as follows:

2. a kind of instant particles as Chinese medicine for treating allergic bronchopulmonary aspergillosis according to claim 1, which is characterized in that system At the raw material composition and parts by weight of the effective ingredient are as follows:

3. a kind of instant particles as Chinese medicine for treating allergic bronchopulmonary aspergillosis according to claim 1, which is characterized in that system At the raw material composition and parts by weight of the effective ingredient are as follows:

4. a kind of instant particles as Chinese medicine for treating allergic bronchopulmonary aspergillosis according to any one of claim 1-3, It is characterized in that, preparation method comprises the following steps that: