CN1250237C - Medicine combination containing white atractylodes rhizome and its preparation method - Google Patents

Abstract

The present invention provides a medicament composition containing lagehead atractylodes of traditional Chinese medicine, and a purpose of a medicament prepared from the medicament composition in the treatment of chronic pharyngolaryngitis and relevant disease. The preparation forms of the medicament composition provided by the present invention mainly comprise a liquid preparation, a granular preparation, a tablet, a granule, a soft pill, a soft capsule, a dripping pill, or an aerosol, etc. The administration form of the medicament composition mainly comprises oral taking administration or non-intestinal tract administration. The preparation of the medicament composition provided by the present invention starts to treat chronic pharyngolaryngitis from causal treatment, is correspond with the theory of the radical treatment in a chronic case of Chinese medicine, and has the characteristics of high cure rate and difficult recrudescence; meanwhile, the problem of difficult cure for a long time, which is puzzled to the patient of chronic pharyngolaryngitis for a long time, is solved. Symptoms can be favorably relieved. The medicament composition has the advantages of easily obtained raw materials, simple and convenient preparation, feasibility and low cost.

Description

The application of the single Rhizoma Atractylodis Macrocephalae in the medicine of preparation treatment chronic pharyngolaryngitis and pharyngolaryngitis relevant disease

Technical field

The invention belongs to Chinese medicine preparation, relate generally to the pharmaceutical composition and the medical usage in the medicine of preparation treatment chronic pharyngolaryngitis and pharyngolaryngitis relevant disease thereof that contain the Chinese medicine Rhizoma Atractylodis Macrocephalae.

Background technology

Chronic pharyngitis, laryngitis are under bottleneck throat mucosa, the mucosa and adenoid chronic inflammatory disease, and diffuse inflammation also can be the part of upper respiratory tract chronic inflammatory disease, and the limitation inflammation then mostly is the adenoid inflammation of throat.Primary disease is very common, and the course of disease is long, and symptom is outbreak repeatedly easily, often is difficult for the impression of healing to people.How to treat clinically at present with antibacterial-anti-inflammatory drug, pharyngeal discomfort that but can not the effectively relieve chronic phase, foreign body sensation, or hypodynia drying sometimes, bottleneck throat has the thick secretions adhering sense, thus the throat of often need coughing, or zest dry cough is arranged, part patient's symptoms such as promptly feeling pharyngeal discomfort, painstaking or hoarseness for a long time of can not talking more or talk has a strong impact on quality of life of patient.

When checking patient's bottleneck throat, pharyngeal reaction is responsive, and pharyngeal mucous membrane has hyperemia, presents kermesinus more or sees the mucosa Mild edema, can be dispersed in the primary lymphedema folliculus, around it blood vessel dilating net is arranged, or is covered with hyalomucoid etc.

There are some researches show, originate from preceding gut entoderm together from embryo development procedure and trachea, stomach, the esophagus of bottleneck throat, in conjunction with throat is again respiratory tract and gastral shared pathway, pharyngeal mucosa is a pseudostratified ciliated columnar epithelium, in goblet cell is arranged, the mixing body of gland is arranged in the lamina propria, pars oralis pharyngis and laryngopharynx portion are stratified squamous epithelium, tela submucosa has mucous gland, and excretory liquid is in order to moistening pharyngeal mucosa., there are a large amount of lymphoid tissues to build up under the epithelial layer herein, constitute the internal ring of pharyngeal lymphaticring jointly with other pharyngeal lymphoid tissues.The sensory nerve and the nervus motorius of pharynx mainly come from the nervus lingualis rami pharyngei, rami pharyngeales nervi vagi, the pharynx that accessory nerve and sympathetic nerve constitute from.Pharyngeal mucus contains lysozyme, and the effect that suppresses with dissolution of bacteria is arranged, and can kill the part invading bacteria, and pharyngeal lymphaticring is even more important to defense against bacterial invasion effect.The motion of pharynx flesh laryngeal muscles and the excretory liquid of submucosal mucous gland are to moistening pharyngeal mucosa, from physiological and pathological, exist certain dependency with digestive tract and respiratory tract, and the opening of the anatomical structure of bottleneck throat and function is the basis of causing laryngopharyngeal diseases, possessed microorganism, the inevitable property of unfavorable factor effects such as pessimal stimulation, singly be not to remove microorganism and pessimal stimulation thing so cure the key of chronic pharyngolaryngitis, and more will improve the barrier function of whole body and local mucous membrane, lymphsystem etc. and improve the function of gastrointestinal respiratory tract throat flesh.

The Rhizoma Atractylodis Macrocephalae is a Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae rhizome, belongs to the tonification Qi-tonifying drug.Warm in nature, sweet in the mouth, hardship.Return spleen, stomach warp, have invigorating the spleen and replenishing QI, dampness diuretic, the effect of strengthening superficial resistance to stop perspiration; Cure mainly deficiency of spleen-QI and stomach-QI, sinking of QI of middle-JIAO, the phlegm retention edema of insufficiency of vital energy and blood and insufficiency of the spleen leading to overabundance of dampness, the spontaneous sweating of exterior deficiency etc." it is that " main air cold-damp low, dead flesh, convulsion subcutaneous ulcer, hidroschesis heat extraction, help digestion, fry in shallow oil bait and owe to obey and make light of one's life by commiting suicide, it is not hungry to prolong life for the record Rhizoma Atractylodis Macrocephalae originally that herbal classic is met." " Amplification on Materia Medica addendum " record Rhizoma Atractylodis Macrocephalae " has antiperspirant then to end, losslessly then send out.Deficiency-phlegm can disappear "." this medical instrument has two-phase to regulate gastrointestinal function, strong, hemopoietic system, and hepatic cholagogic, blood sugar lowering, diuresis, anticoagulation expands blood vessel, antibacterial, antitumor, immunomodulating, antioxidation suppresses the effect of the tonic contraction of uterine smooth muscle " ^1.Clinically often be applied to treat gastrointestinal tract disease, edema, threatened abortion, constipation, aural vertigo, spontaneous sweating due to deficiency of QI night sweat, sialorrhea, leukopenia, rheumatic limbs pain, jaundice.

The compound Chinese medicinal preparation that existing patent documentation report contains the Rhizoma Atractylodis Macrocephalae is used for the treatment of diseases such as hemorrhoid, fistula, pharyngolaryngitis, pharyngitis, throat are not well, put down in writing " a kind of Chinese medicine preparation for the treatment of hemorrhoid, fistula " as CN1163764, said preparation is by powder, the pill of the formulated oral or external of Borneolum Syntheticum, charred Radix Et Rhizoma Rhei, the Rhizoma Atractylodis Macrocephalae, divaricate saposhnikovia charcoal and Fel Sus domestica, cure rate to hemorrhoid reaches 100%, the anal fistula cure rate reaches more than 90%, treatment gynaecologic metrorrhagia disease, toothache there are specially good effect, diseases such as neuropathic pain, otitis, pharyngolaryngitis, rhinitis are also had significant curative effect.CN1131551 has put down in writing " medicated tea of a kind of prevention and treatment chronic pharyngolaryngitis ", this medicated tea is based on Six-element medicines such as Radix Rehmanniae Preparata, Radix Ophiopogonis, add Six-element Chinese herbal medicine such as Radix Asteris, Bulbus Fritillariae Cirrhosae, and be aided with at least three kinds among kind of the Chinese herbal medicine surplus Radix Platycodonis, the Rhizoma Atractylodis Macrocephalae etc. ten, make the packed goods of making tea through simple crushing and screening hybrid process, be used for prevention and treatment chronic pharyngolaryngitis.CN1238962 has put down in writing the tablet that " Kouchouling tablet for treating halitosis " contains ten Six-element Chinese medicines such as Cortex Phellodendri, the Rhizoma Atractylodis Macrocephalae, function with gas among nourishing YIN to lower pathogenic fire, blood pressure lowering, clearing away damp-heat and the guarantor, cure mainly halitosis, acute or chronic gastritis, gastric ulcer, auxilliary hyperlipidemia, pharyngalgia xerostomia or the dry cough without phlegm controlled.The active component of these compound preparations is made up of plurality of Chinese usually, its processing technology relative complex, and production cost is higher, and may have interaction between the multiple composition, and the activity of preparation, stability are all had certain influence.And prior art these compound preparations of just reporting for work have certain curative effect to the treatment chronic pharyngolaryngitis, its DeGrain and the inhibition activity of these compound preparations to chronic pharyngolaryngitis recurrence of not reporting for work.

Summary of the invention

Purpose one of the present invention provides a kind of pharmaceutical composition, mainly contains the Chinese medicine Rhizoma Atractylodis Macrocephalae, also contains medical additive.The preferred unit Chinese medicine preparation contains Rhizoma Atractylodis Macrocephalae 15g (in the dirt medicine).

Pharmaceutical composition provided by the invention, its dosage form mainly comprises liquid preparation, granule, tablet, electuary, soft capsule, soft capsule, drop pill or aerosol etc., preferred liquid preparation.

Pharmaceutical composition provided by the invention is arranged.The form of medication of preparation mainly comprises oral administration or parenterai administration, the preferred oral administration.The parenterai administration form mainly comprises to be sucked or sprays.

Another object of the present invention is the application of the present composition in the medicine of preparation treatment chronic pharyngolaryngitis and pharyngolaryngitis relevant disease.

The present invention has the following advantages:

1. the preparation of pharmaceutical composition provided by the invention according to the theory of the traditional Chinese medical science " radical treatment in chronic case ", is started with from effecting a permanent cure and to be used treatment chronic pharyngolaryngitis and relevant disease, has the cure rate height, is difficult for the characteristics of recurrence.

2. the preparation of pharmaceutical composition provided by the invention has solved the difficult problem of curing of controlling for a long time of long-term puzzlement chronic pharyngolaryngitis patient, well relief of symptoms.

3, use present composition useful in preparing drug formulations, little (the acute LD of Rhizoma Atractylodis Macrocephalae decoct mouse peritoneal injection of toxic and side effects ₅₀Be 13.3 gram/kilograms)

4. use present composition useful in preparing drug formulations, raw material sources are abundant, conventional preparation method, and simple and feasible, cost is low.

Description of drawings

Fig. 1 is for comparing with the curative effect of three kinds of preparations to the chronic pharyngolaryngitis patient treatment.

The specific embodiment

The present invention is described further with the following Examples, and these examples only are used for illustration purpose, and are not used in the restriction scope of the invention.

The preparation of embodiment 1 Rhizoma Atractylodis Macrocephalae volatile oil and Rhizoma Atractylodis Macrocephalae extract

Take by weighing the clean Rhizoma Atractylodis Macrocephalae of required weight by prescription, suitable chopping or pulverizing adopt conventional steam distillation to extract Rhizoma Atractylodis Macrocephalae volatile oil, and the separated and collected Rhizoma Atractylodis Macrocephalae volatile oil is used to prepare Rhizoma Atractylodis Macrocephalae soft capsule or drop pill, aerosol.

After the Rhizoma Atractylodis Macrocephalae extracts volatile oil, add crude drug amount 8-10 deionized water doubly, boil and extracted 1.0-2.0 hour, filter and collect fried liquid, continue to decoct 2 times, merge the fried liquid of each time and also concentrate according to a conventional method by this method, the precipitate with ethanol remove impurity, the extract dry powder that filter, concentrate, drying obtains effective ingredient is used to prepare oral liquid formulations, granule and tablet.

The prescription of embodiment 2 Rhizoma Atractylodis Macrocephalae pharmaceutical compositions is formed

The Rhizoma Atractylodis Macrocephalae (in crude drug) 15g

Medical additive is an amount of

After pressing the active ingredient of the embodiment 1 described method extraction Rhizoma Atractylodis Macrocephalae, according to different preparation requirements, be equipped with conventional medical additive, mainly contain the Chinese medicine preparation of the Rhizoma Atractylodis Macrocephalae again according to the preparation technique preparation of routine, and the unit's of making Chinese medicine preparation contain Rhizoma Atractylodis Macrocephalae 15g (in crude drug).

The preparation of embodiment 3 Rhizoma Atractylodis Macrocephalae oral liquids

Rhizoma Atractylodis Macrocephalae extract (in crude drug) 500g

Ethanol is an amount of

Surfactant (oxybenzene alkyl esters)

Correctives (sucrose or syrup or a small amount of essence)

Distilled water is an amount of

Amount to 1000ml

After above-mentioned substance mixed, carry out the filtration sterilization packing according to a conventional method and make Rhizoma Atractylodis Macrocephalae oral liquid.

The preparation of embodiment 4 Rhizoma Atractylodis Macrocephalae drop pill

Rhizoma Atractylodis Macrocephalae volatile oil 200ml

Sodium stearate 21g

Insect wax 8.4g

Distilled water 8.4ml

After above three kinds of materials are placed the container mixing, shake up after adding water, heating in water bath refluxes again, jolting constantly, and fusing makes uniform solution, and method for preparing drop pills makes drop pill routinely again.

The preparation (solution-type) of embodiment 5 Rhizoma Atractylodis Macrocephalae aerosols

Rhizoma Atractylodis Macrocephalae volatile oil 150ml

Ethanol 550ml

Glucide is an amount of

Essence is an amount of

F ₁₂ 1500ml

Make 180 bottles altogether

Preparation is dissolved in ethanol with Rhizoma Atractylodis Macrocephalae volatile oil, adds glucide, essence is miscible, is sub-packed in the container, and the dress valve is tightened, and is pressed into propellant F ₁₂, shake up, promptly get solution aerosol.

The preparation of Rhizoma Atractylodis Macrocephalae aerosol (emulsion-type)

Rhizoma Atractylodis Macrocephalae volatile oil 10ml

Polyoxyethylene sorbitan monoleate 30g

Sorbitan Oleate 35g

Dodecyl sodium sulfate 20g

Glycerol 250ml

Distilled water adds to 1400ml

F ₁₂ 962.5ml

Make 175 bottles altogether

Preparation with glycerol, the miscible Emulsion that makes of water, is sub-packed in Rhizoma Atractylodis Macrocephalae volatile oil and polyoxyethylene sorbitan monoleate, Sorbitan Oleate and dodecyl sodium sulfate in the container again, and the dress valve is tightened, and is pressed into propellant F ₁₂, shake up, promptly get the emulsion-type aerosol.

The preparation of embodiment 6 Rhizoma Atractylodis Macrocephalae granules, tablet

Rhizoma Atractylodis Macrocephalae granule

Rhizoma Atractylodis Macrocephalae extract 60g

Microcrystalline Cellulose 15g

Cross-linking sodium carboxymethyl cellulose 3g

Sucrose fine 350g

Polyvidone 1g

Malic acid 165g

Saccharin sodium 2.5g

After mixing mentioned component evenly, preparation method prepares Rhizoma Atractylodis Macrocephalae granule routinely.

Rhizoma Atractylodis Macrocephalae tablet

Rhizoma Atractylodis Macrocephalae extract 268g

Starch slurry (17%) is an amount of

Starch 266g

Pulvis Talci 15g

Make 1000 altogether

After mixing mentioned component evenly, preparation method prepares Rhizoma Atractylodis Macrocephalae tablet routinely.

The preparation of embodiment 7 art soft capsules

Rhizoma Atractylodis Macrocephalae volatile oil 5ml

PEG400 (PEG400) 200g

Preparation mixes Rhizoma Atractylodis Macrocephalae volatile oil with 1/8 PEG400, pulverize with colloid mill, and the PEG that adds surplus then is miscible; Get 100 parts in gelatin, 55 parts of glycerol, 120 parts in water preparation gelatin solution puts into that to sprawl case standby; At last with medicinal liquid and gelatin solution routinely pressing make Rhizoma Atractylodis Macrocephalae soft capsule.

The acute toxicity result of embodiment 8 preparations

The used Rhizoma Atractylodis Macrocephalae decoct of acute toxicity testing, according to the method preparation of embodiment 1, experimental program and method are with reference to appended list of references (1) " herbal pharmacology and application ". the report method is carried out among the People's Health Publisher .1998:339.To the mouse peritoneal drug administration by injection, obtain its acute LD ₅₀Be 13.3 gram/kilograms, illustrate that its toxic and side effects is little.

Embodiment 9 clinical experiment results statistics

The patient who chooses 221 examples all has throat discomfort, foreign body sensation, or have dry pharynx, sticking expectorant to be difficult for bringing up, the throat of often coughing, or hoarseness easily appears repeatedly, have a medical check-up: pharyngeal mucosa has edema, lymph follicle, or the mucosa drying, or the symptom performance of throat, vocal cords edema is arranged.Through clinical diagnosis is chronic pharynx, laryngitis, and all through relevant auxiliary examination, gets rid of reason occasioners such as organic and anaphylaxis, male's 119 examples wherein, women's 102 examples; The maximum age is 57 years old, and minimal ages is 7 years old; The course of disease is the shortest 1 year, and is the longest 8 years.

221 routine patients are divided into Rhizoma Atractylodis Macrocephalae treatment at random organize 78 examples, first matched group (antibiotic group), 94 examples, second matched group (watermelon crystal buccal tablet group), 49 examples.

Therapeutic scheme:

1, Rhizoma Atractylodis Macrocephalae treatment group: take Rhizoma Atractylodis Macrocephalae oral liquid, take potion (about crude drug 5g), every day 3 times at every turn.

2, first matched group: the treatment of the penicillin of the dosage that takes a routine treatment respectively, erythromycin, cephalosporin.

3, second matched group: the buccal watermelon crystal buccal tablet, per 2 hours once, each 2.

Therapeutic outcome:

1, criterion of therapeutical effect: clinical symptom disappearance or basic the disappearance, and have a medical check-up and show as, patient's bottleneck throat mucosa is moist level and smooth, edema extinction, and lymph follicle disappears.

2, observation of curative effect: from 221 routine patients, press basic conditions such as morbidity sex, age, disease time, course of disease length, set up Rhizoma Atractylodis Macrocephalae treatment group at random, and carry out different time with first matched group and second matched group and observe, observe after 15 days and all do not have significant difference, (X between each group ²=3.78 p＞0.05), observe after 30 days, Rhizoma Atractylodis Macrocephalae treatment group obviously is better than each matched group, (X ²=24.78 p＜0.05=.Illustrate that Rhizoma Atractylodis Macrocephalae oral liquid obviously is better than the therapeutic effect (see Table 1 and accompanying drawing 1) of antibiotic, watermelon crystal to the treatment of chronic pharyngolaryngitis

Table 1 different time Rhizoma Atractylodis Macrocephalae treatment chronic pharyngolaryngitis observation of curative effect

Observing time	The treatment group		Contrast one group		Contrast two groups
							Take a turn for the better	Invalid	Take a turn for the better	Invalid	Take a turn for the better	Invalid
	15 days 30 days	62 72	16 6	63 70	31 24	33 26							16 23

Embodiment 10 patients cure the Follow-up results analysis after 1 year

Patient cures after 1 year and follows up a case by regular visits to, analyze the recurrence situation of patient's pharyngolaryngitis, the result shows that Rhizoma Atractylodis Macrocephalae treatment group and each matched group learn processing by statistics, and the relapse rate of Rhizoma Atractylodis Macrocephalae treatment group is starkly lower than each matched group, does not relatively have the significance difference opposite sex (seeing Table 2) and contrast between 2 groups of 1 group and contrasts

Table 2 Rhizoma Atractylodis Macrocephalae treatment group and matched group recurred Follow-up results after 1 year

	Rhizoma Atractylodis Macrocephalae treatment group	Contrast one group	Contrast two groups
				Recurrence does not have recurrence	10 68	56 38	24 25

Remarks: 1 group of X of Rhizoma Atractylodis Macrocephalae treatment group and contrast ²=39.40 p＜0.05

2 groups of X of Rhizoma Atractylodis Macrocephalae treatment group and contrast ²=20.06 p＜0.05

Contrast 1 group and 2 groups and compare X ²=1.46 p＞0.05

Referring to Fig. 1, the chronic pharyngolaryngitis patient is accepted ovate attractylodes medicinal preparation of the present invention, antibiotic and the treatment effective percentage of watermelon crystal treatment after 15 days and 30 days relatively, and cure and followed up a case by regular visits to relapse rate in back 1 year relatively.As seen, compare with the treatment of antibiotic and watermelon crystal, the ovate attractylodes medicinal preparation that the present invention makes has better therapeutical effect to chronic pharyngolaryngitis, and can effectively prevent its recurrence.

Pharmaceutical preparation of the present invention to the therapeutical effect of chronic pharyngolaryngitis based on following result of study: 1) Rhizoma Atractylodis Macrocephalae decoct has strong effect, to mouse stomach, once a day, schedules to last January, can promote weight increase and strengthen the muscle power of swimming ^2.2) can activate reticuloendothelial system ^3., strengthen its phagocytic activity ^4., make the phagocytic percentage of macrophage.Phagocytic index and lysosome digestibility significantly increase ^5.-7.To the leukopenia that treatment or radiotherapy by chemistry cause, Rhizoma Atractylodis Macrocephalae decoct has function of increasing leukocyte ^8.The Rhizoma Atractylodis Macrocephalae can also improve lymhocyte transformation rate and Flos Rosae Rugosae formation rate, promotes cellular immune function, and obviously increases serum IgG ^9.Immunoloregulation function: the Rhizoma Atractylodis Macrocephalae can make immunosuppressant animal T _HCell number obviously increases, and improves T _H/ T _SRatio increases the expression of T cell surface IL-2R, and the IL-2R level is significantly improved ^10.3) two-phase is regulated gastrointestinal function: show that with the stripped intestinal test of rabbit under normal circumstances, Rhizoma Atractylodis Macrocephalae decoct has slight excitation.When intestinal tube is subjected to acetylcholine and barium chloride excitation time, the Rhizoma Atractylodis Macrocephalae is inhibitory action; When intestinal tube was subjected to epinephrine inhibited, the Rhizoma Atractylodis Macrocephalae was excitation, and antagonism is obvious ⁽¹¹⁾4) have again simultaneously antibacterial, activate effects such as lysosomal active function in the mucosa and diuresis detumescent, antioxidation, anticoagulation, blood vessel dilating, microcirculation improvement, the pathophysiological process that promptly meets chronic pharyngolaryngitis, the theory with the traditional Chinese medical science " radical treatment in chronic case " matches again.

Conclusion: as can be seen, Rhizoma Atractylodis Macrocephalae Chinese medicine preparation of the present invention is according to the theory of the traditional Chinese medical science " radical treatment in chronic case " from above example, the treatment chronic pharyngolaryngitis of starting with from effecting a permanent cure, accept antibiotic with the patient or watermelon crystal is compared, have the cure rate height, be difficult for the characteristics of recurrence.

Embodiment 11 model cases

Case one

Lu, man, 38 years old, the factory director of enterprise

The main suit: the throat of coughing repeatedly, sticking expectorant is difficult for bringing up 8 years

The patient often has throat discomfort and bottleneck throat thick secretions adhering sense over nearly 8 years, the throat of often coughing how in tired or the postemphasis of talking, and has zest dry cough more, once uses multiple antibiotic, treatments such as Chinese patent medicine and glucocorticoid.The patient has denied cardiovascular and cerebrovascular vessel, breathing and digestive system disease history, denies infecting medical history.Have a medical check-up: 36.3 ℃ of body temperature, blood pressure 128/72mmHg, spirit can, skin does not have xanthochromia, and is handsome, the pharyngeal mucosa mild hyperaemia, the vasoganglion hypertrophy is arranged, as seen be dispersed in more Semen Glycines size lymph foilicie hyperplasia, table covers a small amount of white thick secretions, thyroid does not touch enlargement, heart rate 78 times/minute, and rule is neat, two lungs are not heard and the hello sound, the stomach wall palpation is flat soft, does not touch enclosed mass, and the liver spleen does not touch enlargement, two kidneys district does not have the pain of kowtowing, and extremity are not different from, and neurologic check is no abnormal.Auxiliary examination: routine blood test, routine urinalysis, erythrocyte sedimentation rate, stool routine examination, stool " OB ", chest x-ray are taken the photograph sheet, Abdominal B type ultrasonography etc. and are checked all no abnormal.

Diagnosis: chronic pharyngolaryngitis

Treatment: it is oral to give Rhizoma Atractylodis Macrocephalae liquid preparation (about crude drug 15g every day) branch 3 times, treatment is one month continuously, clinical symptoms is alleviated substantially, check pharyngeal mucosa lymph follicle reduces half, do not see that thick secretions adheres to, continue to strengthen treatment 2 months, the pharyngeal mucosa Smooth and moist, lymph follicle disappears, and follows up a case by regular visits to and does not see recurrence in 3 years.

Case two

Poplar, woman, 34 years old, teacher

Main suit: repeated hoarseness 3 years

The patient is every because of hoarseness takes place more for the back of talking, and with pharyngalgia, but does not have heating when the state of an illness is heavy, does not have cough, adds treatments such as glucocorticoid through antibiotic, when postponing hoarseness at the beginning, but nearly 3 months over through above treatment, the hoarseness symptom is failed alleviation.Patient's ordinary circumstance is normal, has denied the liver and gall medical history, has denied the pulmonary tuberculosis medical history, no trauma surgery history.Have a medical check-up: there is not heating, handsome, pharyngeal mucosa congestion and edema, throat's vocal cords mucosa Mild edema, the visible 2 place's trifles of vocal cords are swollen, and the rhythm of the heart is neat, and two lungs are not heard and the hello sound, and abdominal part is flat soft, the liver spleen does not touch enlargement, and two kidneys district does not have the pain of kowtowing, and extremity are not different from, and neurologic check is no abnormal.Auxiliary examination: routine blood test, routine urinalysis, erythrocyte sedimentation rate, stool routine examination, stool " OB ", chest x-ray are taken the photograph sheet etc. and are checked all no abnormal.

Diagnosis: chronic pharyngolaryngitis, vocal nodule.

Treatment: give 7 days hoarsenesss of Rhizoma Atractylodis Macrocephalae oral liquid formulations (about crude drug 15g every day) treatment and alleviate 1/3rd, two weeks turns for the better by and large, and treats 2 months hoarsenesss continuously and alleviates fully, continues to strengthen treatment 1 month, with examining not recurrence in 1 year.

Case three

Dissolve certain, woman, 27 years old, medicine canvasser

Main suit: dry pharynx, companion's zest dry cough a year and a half.

The patient often feel dry pharynx discomfort and zest dry cough a year and a half many, in tired, secondary pharyngalgia heating when not having enough sleep, often can alleviate through the heating of treatment pharyngalgia such as antibiotic and buccal tablet, but dry pharynx is not healed repeatedly, the patient denies bronchitis and bronchial asthma medical history, denies the liver and gall medical history, denies diabetic history, free from infection and history of operation have been denied the allergic constitution history.

Have a medical check-up: 36.4 ℃ of body temperature, blood pressure 112/67mmHg, handsome, the pharyngeal mucosa flaccidity drying that contracts, do not see lymph follicle, bilateral amygdala I ° enlargement, no rheuminess thing adheres to, and throat is not different from, the rhythm of the heart is neat, and two lungs are not heard and the hello sound, and the liver spleen does not touch enlargement, and two kidneys district does not have the pain of kowtowing.Auxiliary examination: routine blood test, routine urinalysis, erythrocyte sedimentation rate, stool routine examination, stool " OB ", blood IgE, fasting glucose, liver function, renal function, a thyroid function complete set, chest x-ray are taken the photograph sheet etc. and are checked all no abnormal.

Diagnosis: chronic pharyngitis, chronic tonsillitis.

Treatment: give ovate attractylodes medicinal preparation (about crude drug 15g every day) divide 3 times oral, treated dry pharynx alleviation, after treatment 1 month 1 month.With examining not recurrence in 1 year.

Case four

Lu, man, 7 years old, pupil

Main suit: coughed 1 year

The patient is many to be repeatedly and to cough at time-out and having a meal or cough 1 year when movable in morning, coughs when violent with nausea and vomiting, does not have heating, invalid through antibiotic therapy.Patient's ordinary circumstance is all not different from, and growth promoter is normal, denies hepatitis history, denies the bronchitis medical history, denies infecting medical history, no trauma surgery history.

Have a medical check-up: 36.5 ℃ of body temperature, five pipe ends just, nutritional development is normal, the pharyngeal mucosa congestion and edema is seen more lymph follicle, adularescent secretions adheres to, throat's mucosa is not different from, the rhythm of the heart is neat, two lungs are not heard and the hello sound, abdominal part is flat soft, the liver spleen does not touch enlargement, extremity are not different from.Auxiliary examination: routine blood test, routine urinalysis, erythrocyte sedimentation rate, stool routine examination, stool " OB ", chest x-ray are taken the photograph sheet etc. and are checked all no abnormal.

Treatment: give the oral two weeks cough of ovate attractylodes medicinal preparation (approximately every day crude drug 10g) and reduce by cough in 2/3,1 month and alleviate.The check pharyngeal mucosa does not have congestion and edema, and lymph follicle disappears, and continues to strengthen the treatment two weeks, follows up a case by regular visits to and does not have recurrence in 1 year.

Need not further to elaborate, believe and adopt the disclosed content in front, those skilled in the art can use the present invention to greatest extent.All quote in this application as a reference at all documents that the present invention mentions, just quoted as a reference separately as each piece document.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after having read above-mentioned teachings of the present invention, these equivalent form of values fall within the application's appended claims institute restricted portion equally.

The partial reference document that the present invention relates to:

(1) king bathes life. Deng Wenlong. and Xue Chunsheng chief editor, " herbal pharmacology and application ". People's Health Publisher .1998:337

(2) Zou ancestral god etc. academy of traditional Chinese medicine's research data transactions (first volume) .1959.159

(3) on the open country truth he. foreign medical science (Chinese medicine fascicle), 1988,10 (1): 47

(4) ocean, western river one he. pharmacognosy magazine, 1975,29 (2): 139

(5) Meng Xianyi. Chinese patent medicine research, 1982, (10): 40

(6) carry beautiful as etc. Nanjing Traditional Chinese Medical College's journal, 1988,4:40

(7) Hu Zuguang etc. combination of Chinese and Western medicine magazine, 1984,4 (6) 363

(8) Chen Huizhong. military medicine news in brief, 1977, (2): 5

(9) Song Fangji etc. new medicine and pharmacology magazine, 1979, (6): 60

(10) just wait on surplus. Shanghai Journal of Immunology, 1994,14 (1): 12

(11) Ma Yun consoles etc. Chinese patent medicine research, 1982, (12): 26

Claims (1)

1. the application of the single Rhizoma Atractylodis Macrocephalae in the medicine of preparation treatment chronic pharyngolaryngitis and pharyngolaryngitis relevant disease.

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