CN102137675A - 通过阳离子脂质的对映体刺激免疫应答 - Google Patents

通过阳离子脂质的对映体刺激免疫应答 Download PDF

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Publication number
CN102137675A
CN102137675A CN200980121761XA CN200980121761A CN102137675A CN 102137675 A CN102137675 A CN 102137675A CN 200980121761X A CN200980121761X A CN 200980121761XA CN 200980121761 A CN200980121761 A CN 200980121761A CN 102137675 A CN102137675 A CN 102137675A
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Prior art keywords
antigen
dotap
cationic lipid
antigens
chiral
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Chinese (zh)
Inventor
E.A.瓦西维奇
W.陈
K.托尼
G.孔
F.贝杜-阿多
L.黄
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PDS Biotechnology Corp
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PDS Biotechnology Corp
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Priority to CN201811312211.3A priority Critical patent/CN110075113A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200980121761XA 2008-04-17 2009-04-14 通过阳离子脂质的对映体刺激免疫应答 Pending CN102137675A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811312211.3A CN110075113A (zh) 2008-04-17 2009-04-14 通过阳离子脂质的对映体刺激免疫应答

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4583708P 2008-04-17 2008-04-17
US61/045837 2008-04-17
PCT/US2009/040500 WO2009129227A1 (en) 2008-04-17 2009-04-14 Stimulation of an immune response by enantiomers of cationic lipids

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CN201811312211.3A Pending CN110075113A (zh) 2008-04-17 2009-04-14 通过阳离子脂质的对映体刺激免疫应答

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US (4) US9789129B2 (enExample)
EP (1) EP2276495B1 (enExample)
JP (1) JP5971945B2 (enExample)
CN (2) CN102137675A (enExample)
AU (1) AU2009236306B2 (enExample)
BR (1) BRPI0910464B1 (enExample)
CA (1) CA2721366C (enExample)
ES (1) ES2712505T3 (enExample)
IL (1) IL208713A (enExample)
PL (1) PL2276495T3 (enExample)
RU (1) RU2530555C2 (enExample)
TW (1) TWI449534B (enExample)
WO (1) WO2009129227A1 (enExample)

Cited By (8)

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CN104066444A (zh) * 2011-09-12 2014-09-24 Pds生物科技公司 微粒疫苗制剂
CN105101991A (zh) * 2012-09-21 2015-11-25 Pds生物科技公司 改进的疫苗组合物和使用方法
CN105163753A (zh) * 2012-06-15 2015-12-16 Pds生物科技公司 阳离子脂质疫苗组合物和使用方法
CN110461355A (zh) * 2016-10-31 2019-11-15 艾金株式会社 包含免疫调控剂和阳离子脂质体的免疫增强的组合物及其用途
CN114980919A (zh) * 2019-11-18 2022-08-30 儿童医学中心公司 过度活化驻留树突状细胞的刺激物用于癌症免疫疗法
US11612652B2 (en) 2015-11-13 2023-03-28 Pds Biotechnology Corporation Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy
US11801257B2 (en) 2008-04-17 2023-10-31 Pds Biotechnology Corporation Stimulation of an immune response by enantiomers of cationic lipids
US11911359B2 (en) 2007-03-22 2024-02-27 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids

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US20180221475A1 (en) * 2016-10-05 2018-08-09 Pds Biotechnology Corporation Methods to alter the tumor microenvironment for effective cancer immunotherapy
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CA3084957A1 (en) * 2017-12-05 2019-06-13 Pds Biotechnology Corporation Methods and compositions comprising cationic lipids for stimulating type 1 interferon genes
US20220160867A1 (en) * 2020-11-20 2022-05-26 Pds Biotechnology Corporation Methods and compositions comprising cationic lipids for immunotherapy by direct tumor injection
CN120584129A (zh) * 2022-10-19 2025-09-02 Pds生物科技公司 用于治疗表达黏蛋白1蛋白的人癌症的新型t细胞活化免疫治疗

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