CN102128904B - 甲钴胺残留有机溶剂检测方法 - Google Patents
甲钴胺残留有机溶剂检测方法 Download PDFInfo
- Publication number
- CN102128904B CN102128904B CN201010582131.7A CN201010582131A CN102128904B CN 102128904 B CN102128904 B CN 102128904B CN 201010582131 A CN201010582131 A CN 201010582131A CN 102128904 B CN102128904 B CN 102128904B
- Authority
- CN
- China
- Prior art keywords
- acetone
- tetrahydrofuran
- solution
- chromatographic peak
- mecobalamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229960005321 mecobalamin Drugs 0.000 title claims abstract description 21
- JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 title claims abstract description 21
- 235000007672 methylcobalamin Nutrition 0.000 title claims abstract description 21
- 239000011585 methylcobalamin Substances 0.000 title claims abstract description 21
- 239000003960 organic solvent Substances 0.000 title claims abstract description 10
- 238000000034 method Methods 0.000 title claims abstract description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 90
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims abstract description 74
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims abstract description 34
- 238000012360 testing method Methods 0.000 claims abstract description 29
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000011084 recovery Methods 0.000 claims abstract description 12
- 239000013558 reference substance Substances 0.000 claims abstract description 12
- 238000010813 internal standard method Methods 0.000 claims abstract description 5
- 239000007789 gas Substances 0.000 claims description 14
- 239000012159 carrier gas Substances 0.000 claims description 3
- 239000006200 vaporizer Substances 0.000 claims description 3
- 238000003556 assay Methods 0.000 claims description 2
- 238000004364 calculation method Methods 0.000 claims description 2
- 238000005259 measurement Methods 0.000 claims description 2
- 238000004817 gas chromatography Methods 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 239000012488 sample solution Substances 0.000 abstract 3
- 239000000523 sample Substances 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 210000004126 nerve fiber Anatomy 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Landscapes
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010582131.7A CN102128904B (zh) | 2010-12-10 | 2010-12-10 | 甲钴胺残留有机溶剂检测方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010582131.7A CN102128904B (zh) | 2010-12-10 | 2010-12-10 | 甲钴胺残留有机溶剂检测方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102128904A CN102128904A (zh) | 2011-07-20 |
CN102128904B true CN102128904B (zh) | 2014-07-30 |
Family
ID=44267070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201010582131.7A Active CN102128904B (zh) | 2010-12-10 | 2010-12-10 | 甲钴胺残留有机溶剂检测方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102128904B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106770726B (zh) * | 2016-11-29 | 2019-03-05 | 无锡福祈制药有限公司 | 一种甲钴胺残留有机溶剂的检测方法 |
CN113176326B (zh) * | 2021-04-26 | 2022-08-23 | 上汽大众汽车有限公司 | 清洗液甲醇含量的检测方法 |
-
2010
- 2010-12-10 CN CN201010582131.7A patent/CN102128904B/zh active Active
Non-Patent Citations (6)
Title |
---|
KINETICS AND MECHANISM OF THE REACTION BETWEEN METHYLCOBALAMIN AND MERCURIC CHLORIDE;P.J.CRAIG et al;《Journal of Organometallic Chemistry》;19781231(第145期);79-89 * |
P.J.CRAIG et al.KINETICS AND MECHANISM OF THE REACTION BETWEEN METHYLCOBALAMIN AND MERCURIC CHLORIDE.《Journal of Organometallic Chemistry》.1978,(第145期),79-89. |
周明昊等.顶空毛细管气相色谱法测定格列吡嗪中的残留溶剂.《药物分析杂志》.2008,第28卷(第5期),810-813. |
盐酸奥洛他定中有机溶剂残留量的毛细管GC测定;韩学静等;《中国医药工业杂志》;20080731;第39卷(第7期);535-537 * |
韩学静等.盐酸奥洛他定中有机溶剂残留量的毛细管GC测定.《中国医药工业杂志》.2008,第39卷(第7期),535-537. |
顶空毛细管气相色谱法测定格列吡嗪中的残留溶剂;周明昊等;《药物分析杂志》;20080531;第28卷(第5期);810-813 * |
Also Published As
Publication number | Publication date |
---|---|
CN102128904A (zh) | 2011-07-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104655751B (zh) | 一种检测达泊西汀中有机溶剂残留的方法 | |
CN105717230B (zh) | 一种检测法匹拉韦中有机溶剂残留的方法 | |
CN103487519A (zh) | 一种检测药物中多种残留溶媒的方法 | |
CN112345651B (zh) | 测定水合氯醛或其制剂中卤代酸含量的方法 | |
CN106645497A (zh) | 一种奥贝胆酸及其制剂中有关物质的检测方法 | |
CN103698424B (zh) | 一种测定难溶性铝盐药物中有机溶剂的检测方法 | |
CN102998396B (zh) | 一种水中环氧氯丙烷的测定方法 | |
CN103630628B (zh) | 一种用于检测咪唑类驱虫药中甲酸残留的方法 | |
CN102128904B (zh) | 甲钴胺残留有机溶剂检测方法 | |
Geryk et al. | A supercritical fluid chromatography method for the systematic toxicology analysis of cannabinoids and their metabolites | |
CN101458235B (zh) | 苦参碱液相色谱测定方法 | |
CN113533610A (zh) | 一种测定原料药中哌啶残留的检测方法 | |
CN105806968A (zh) | 同时检测正庚烷、异辛烷、乙酸乙酯、异丙醇的气相色谱分析方法及其应用 | |
CN107356698B (zh) | 一种样品中2-甲基吡啶和2-氯-6-三氯甲基吡啶的同时定量测定方法 | |
CN110221004A (zh) | 一种环氧氯丙烷的检测方法及应用 | |
CN105158348A (zh) | 利用气相色谱法对莪术油中五种有效成分测定的方法 | |
CN103149314A (zh) | 单硝酸异山梨酯注射液中1,2-丙二醇的鉴别和含量测定方法 | |
CN114518413B (zh) | 一种卡托普利原料药中脯氨酸的含量测定方法 | |
CN114660196A (zh) | 含多组分复方山梨醇溶液的药品中有关物质的测定方法 | |
CN103424497A (zh) | 一种氯甲酸异丁酯的检测方法 | |
CN112305100B (zh) | 一种药物中基因毒性杂质溴化苄含量的检测方法 | |
CN105467027A (zh) | 一种用气相色谱法分离测定米诺膦酸中间体有关物质的方法 | |
CN107966498B (zh) | 一种检测艾代拉里斯中溶剂残留的方法 | |
CN111077246A (zh) | 一种应用超高效液相色谱-串联质谱检测4-甲氧基邻苯二胺的方法 | |
CN102507776A (zh) | 一种测定水中苯酚含量的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: NINGXIA KINGVIT PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: NINGXIA TAIRUI PHARMACEUTICAL CO., LTD. Effective date: 20150107 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20150107 Address after: 750101 the Ningxia Hui Autonomous Region Yinchuan telescope Development Zone Patentee after: Ningxia Jin Wei Pharmacy stock Co., Ltd Address before: 750101 the Ningxia Hui Autonomous Region Yinchuan telescope Development Zone Patentee before: Ningxia Tairui Pharmaceutical Co., Ltd. |