CN102127005B - 阿维莫潘的中间体及其合成方法 - Google Patents
阿维莫潘的中间体及其合成方法 Download PDFInfo
- Publication number
- CN102127005B CN102127005B CN2011100011604A CN201110001160A CN102127005B CN 102127005 B CN102127005 B CN 102127005B CN 2011100011604 A CN2011100011604 A CN 2011100011604A CN 201110001160 A CN201110001160 A CN 201110001160A CN 102127005 B CN102127005 B CN 102127005B
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- weimopan
- alvimopan
- follows
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CCCN(C)C[C@](Cc1ccccc1)C(NCC(O*)=O)=O Chemical compound CCCN(C)C[C@](Cc1ccccc1)C(NCC(O*)=O)=O 0.000 description 3
- RDKAACDNLFKXSJ-DVBNTOJCSA-N CCOC(CNC([C@@H](Cc1ccccc1)CN(CC1)C[C@H](C)[C@]1(C)c1cc(O)ccc1)=O)=O Chemical compound CCOC(CNC([C@@H](Cc1ccccc1)CN(CC1)C[C@H](C)[C@]1(C)c1cc(O)ccc1)=O)=O RDKAACDNLFKXSJ-DVBNTOJCSA-N 0.000 description 1
- GRSNDKHAOLJCJT-JDRJUVJTSA-N C[C@@H](CN(C[C@@H](CC(NCC(O)=O)=O)Cc1ccccc1)CC1)[C@]1(C)c1cccc(O)c1 Chemical compound C[C@@H](CN(C[C@@H](CC(NCC(O)=O)=O)Cc1ccccc1)CC1)[C@]1(C)c1cccc(O)c1 GRSNDKHAOLJCJT-JDRJUVJTSA-N 0.000 description 1
- UPNUIXSCZBYVBB-JVFUWBCBSA-N C[C@@H](CN(C[C@H](Cc1ccccc1)C(NCC(O)=O)=O)CC1)[C@]1(C)c1cc(O)ccc1 Chemical compound C[C@@H](CN(C[C@H](Cc1ccccc1)C(NCC(O)=O)=O)CC1)[C@]1(C)c1cc(O)ccc1 UPNUIXSCZBYVBB-JVFUWBCBSA-N 0.000 description 1
- FEHPATFOJAWXIY-UHFFFAOYSA-N NCOCc1ccccc1 Chemical compound NCOCc1ccccc1 FEHPATFOJAWXIY-UHFFFAOYSA-N 0.000 description 1
- YBVOFPCMAWCRAA-ZEQRLZLVSA-N O=C([C@@H](Cc1ccccc1)COCc1ccccc1)N([C@@H](CO1)c2ccccc2)C1=O Chemical compound O=C([C@@H](Cc1ccccc1)COCc1ccccc1)N([C@@H](CO1)c2ccccc2)C1=O YBVOFPCMAWCRAA-ZEQRLZLVSA-N 0.000 description 1
- XWKUMWCUKJYIPB-INIZCTEOSA-N OC([C@@H](Cc1ccccc1)COCc1ccccc1)=O Chemical compound OC([C@@H](Cc1ccccc1)COCc1ccccc1)=O XWKUMWCUKJYIPB-INIZCTEOSA-N 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011100011604A CN102127005B (zh) | 2011-01-05 | 2011-01-05 | 阿维莫潘的中间体及其合成方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011100011604A CN102127005B (zh) | 2011-01-05 | 2011-01-05 | 阿维莫潘的中间体及其合成方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102127005A CN102127005A (zh) | 2011-07-20 |
CN102127005B true CN102127005B (zh) | 2012-11-21 |
Family
ID=44265320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011100011604A Active CN102127005B (zh) | 2011-01-05 | 2011-01-05 | 阿维莫潘的中间体及其合成方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102127005B (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011161646A2 (en) * | 2010-06-25 | 2011-12-29 | Ranbaxy Laboratories Limited | Process for the preparation of alvimopan or its pharmaceutically acceptable salt or solvate thereof |
CN102417463B (zh) * | 2011-11-03 | 2016-12-21 | 北京华禧联合科技发展有限公司 | 阿维莫泮的制备方法 |
CN103288716B (zh) * | 2012-03-02 | 2016-02-10 | 江苏恩华药业股份有限公司 | 一种用于制备阿维莫潘的新中间体及其制备方法和用其制备阿维莫潘的方法 |
CN103360300B (zh) * | 2012-03-26 | 2015-02-04 | 信泰制药(苏州)有限公司 | 一种阿维莫泮的合成方法 |
CN103360302B (zh) * | 2012-03-29 | 2015-08-26 | 北大方正集团有限公司 | 阿维莫泮的纯化方法 |
CN102702076B (zh) * | 2012-05-09 | 2014-06-04 | 江苏恩华药业股份有限公司 | 一种用于制备阿维莫潘的化合物及其制备方法和应用 |
CN102757379B (zh) * | 2012-07-17 | 2014-01-22 | 上海皓元生物医药科技有限公司 | 一种爱维莫潘的制备方法 |
CN110128324A (zh) * | 2019-06-19 | 2019-08-16 | 中南林业科技大学 | 一种爱维莫潘中间体的手性合成方法及其中间体 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1827598A (zh) * | 2006-03-07 | 2006-09-06 | 天津泰普药品科技发展有限公司 | 阿韦苄酯化合物及其制备方法和以该化合物制备阿韦莫哌的新工艺 |
-
2011
- 2011-01-05 CN CN2011100011604A patent/CN102127005B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1827598A (zh) * | 2006-03-07 | 2006-09-06 | 天津泰普药品科技发展有限公司 | 阿韦苄酯化合物及其制备方法和以该化合物制备阿韦莫哌的新工艺 |
Non-Patent Citations (1)
Title |
---|
VICTORIA PEDDIE ET AL..Fluorinated β2-and β3-Amino Acids: Synthesis and Inhibition of a-Chymotrypsin.《SYNTHESIS》.2010,(第11期),1845-1859. * |
Also Published As
Publication number | Publication date |
---|---|
CN102127005A (zh) | 2011-07-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102127005B (zh) | 阿维莫潘的中间体及其合成方法 | |
CN104230777A (zh) | 一种奥拉西坦的合成方法 | |
CN104860894B (zh) | 一种抗心衰药lcz696的制备方法 | |
CN103664912B (zh) | 一种普卡必利的合成工艺 | |
CN104926790A (zh) | 一种高纯度 Vonoprazan Fumarate化合物及其中间体、杂质以及它们的制备方法 | |
CN105814020A (zh) | 用于大规模生产1-[(2-溴苯基)磺酰基]-5-甲氧基-3-[(4-甲基-1-哌嗪基)甲基]-1h-吲哚二甲磺酸盐一水合物的方法 | |
CN102190628B (zh) | 一种5-氟-6-乙基-4-羟基嘧啶中间体及伏立康唑的制备方法 | |
CN105330582B (zh) | (r)-4-羟基-2-氧代-1-吡咯烷乙酰胺的制备方法 | |
CN102395591B (zh) | 一种合成普拉格雷的方法 | |
CN105330581A (zh) | 一种(s)-奥拉西坦的制备方法 | |
CN103554031B (zh) | 阿齐沙坦中间体的制备方法 | |
CN101967118A (zh) | 爱维莫潘的制备方法 | |
CN103664896A (zh) | 一种新的抗肿瘤分子靶向药物克里唑替尼的合成工艺方法 | |
CN102532128B (zh) | 托烷司琼的合成方法以及盐酸托烷司琼的制备方法 | |
CN105358529B (zh) | 一种合成阿哌沙班重要中间体的新方法 | |
CN103864773B (zh) | 利伐沙班及其中间体的制备方法 | |
CN104557877A (zh) | 一种阿伐那非中间体及其制备方法和应用 | |
CN102827152B (zh) | 噻加宾的制备方法及其前体化合物 | |
CN102491992A (zh) | 一种碳青霉烯类抗生素关键中间体4-bma的制备方法 | |
CN101723954B (zh) | 一种制备奥氮平的工艺 | |
CN105037193A (zh) | 一种奥替溴铵的制备方法 | |
CN103360300B (zh) | 一种阿维莫泮的合成方法 | |
CN100486977C (zh) | 雷莫司琼的一种新制备方法 | |
CN103159641A (zh) | 托伐普坦中间体2-甲酸-5-(2-甲基苯甲酰氨基)甲苯的制备方法 | |
CN103288813A (zh) | 一种阿瑞匹坦的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20110720 Assignee: Hainan Visum Pharmaceutical Co., Ltd. Assignor: Borui Bio-medical Technology (Jiangsu) Co., Ltd. Contract record no.: 2012460000016 Denomination of invention: Intermediate of alvimopan and synthesis method thereof Granted publication date: 20121121 License type: Exclusive License Record date: 20121211 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
C56 | Change in the name or address of the patentee | ||
CP03 | Change of name, title or address |
Address after: Suzhou City, Jiangsu Province, Suzhou Industrial Park 215123 Xinghu Street No. 218 Nano Technology Park building C25 Patentee after: Borui Pharmaceutical (Suzhou) Limited by Share Ltd Address before: Xinghu Street Industrial Park of Suzhou city in Jiangsu province 215123 No. 218 nano technology park A3 building 420 room Patentee before: Borui Bio-medical Technology (Jiangsu) Co., Ltd. |