CN1021225C - 稳定的青霉素衍生物的水合物的制备方法 - Google Patents
稳定的青霉素衍生物的水合物的制备方法 Download PDFInfo
- Publication number
- CN1021225C CN1021225C CN87106308A CN87106308A CN1021225C CN 1021225 C CN1021225 C CN 1021225C CN 87106308 A CN87106308 A CN 87106308A CN 87106308 A CN87106308 A CN 87106308A CN 1021225 C CN1021225 C CN 1021225C
- Authority
- CN
- China
- Prior art keywords
- methyl
- asparaginylamoxicillin
- solution
- trihydrate
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/18—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
- C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61226423A JPS6379888A (ja) | 1986-09-24 | 1986-09-24 | ペニシリン誘導体の安定型水和物 |
| JP2264/86 | 1986-09-24 | ||
| JP226423/86 | 1986-09-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN87106308A CN87106308A (zh) | 1988-04-13 |
| CN1021225C true CN1021225C (zh) | 1993-06-16 |
Family
ID=16844890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN87106308A Expired - Fee Related CN1021225C (zh) | 1986-09-24 | 1987-09-12 | 稳定的青霉素衍生物的水合物的制备方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4866170A (OSRAM) |
| EP (1) | EP0261823B1 (OSRAM) |
| JP (1) | JPS6379888A (OSRAM) |
| KR (1) | KR920003902B1 (OSRAM) |
| CN (1) | CN1021225C (OSRAM) |
| AT (2) | ATE59655T1 (OSRAM) |
| AU (1) | AU592467B2 (OSRAM) |
| CA (1) | CA1286285C (OSRAM) |
| DE (1) | DE3766921D1 (OSRAM) |
| DK (1) | DK167319B1 (OSRAM) |
| ES (1) | ES2026545T3 (OSRAM) |
| FI (1) | FI86853C (OSRAM) |
| GR (1) | GR3001274T3 (OSRAM) |
| HK (1) | HK42093A (OSRAM) |
| HU (1) | HU196810B (OSRAM) |
| IE (1) | IE60042B1 (OSRAM) |
| IL (1) | IL83786A (OSRAM) |
| MY (1) | MY102553A (OSRAM) |
| NO (1) | NO169717C (OSRAM) |
| PH (1) | PH23644A (OSRAM) |
| PT (1) | PT85773B (OSRAM) |
| SG (1) | SG15393G (OSRAM) |
| SU (1) | SU1517764A3 (OSRAM) |
| ZA (1) | ZA876739B (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5375123A (en) * | 1993-02-05 | 1994-12-20 | Telefonakitebolaget L. M. Ericsson | Allocation of channels using interference estimation |
| US6473602B1 (en) | 1996-10-28 | 2002-10-29 | Ericsson Inc. | Mobile assisted handoff in radiocommunication systems |
| PE20000879A1 (es) * | 1998-04-29 | 2000-09-23 | Dsm Nv | METODO PARA CRISTALIZAR UN ANTIBIOTICO ß-LACTAMICO |
| KR101879756B1 (ko) * | 2016-11-30 | 2018-08-17 | 주식회사 지앤지비 | 욕실용 난방기 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6705789A (OSRAM) * | 1967-03-08 | 1968-09-09 | ||
| GB1241844A (en) * | 1968-08-23 | 1971-08-04 | Beecham Group Ltd | Penicillins |
| US4053609A (en) * | 1975-09-12 | 1977-10-11 | Tanabe Seiyaku Co., Ltd. | Penicillins and processes for preparing the same |
| JPS5640686A (en) * | 1979-09-11 | 1981-04-16 | Tanabe Seiyaku Co Ltd | Purification of penicillin derivative |
-
1986
- 1986-09-24 JP JP61226423A patent/JPS6379888A/ja active Granted
-
1987
- 1987-09-01 IE IE234687A patent/IE60042B1/en not_active IP Right Cessation
- 1987-09-03 AT AT87307794T patent/ATE59655T1/de not_active IP Right Cessation
- 1987-09-03 EP EP87307794A patent/EP0261823B1/en not_active Expired - Lifetime
- 1987-09-03 ES ES198787307794T patent/ES2026545T3/es not_active Expired - Lifetime
- 1987-09-03 DE DE8787307794T patent/DE3766921D1/de not_active Expired - Lifetime
- 1987-09-04 IL IL83786A patent/IL83786A/xx not_active IP Right Cessation
- 1987-09-09 ZA ZA876739A patent/ZA876739B/xx unknown
- 1987-09-11 PH PH35805A patent/PH23644A/en unknown
- 1987-09-12 CN CN87106308A patent/CN1021225C/zh not_active Expired - Fee Related
- 1987-09-18 US US07/098,364 patent/US4866170A/en not_active Expired - Fee Related
- 1987-09-22 AU AU78827/87A patent/AU592467B2/en not_active Ceased
- 1987-09-22 MY MYPI87001873A patent/MY102553A/en unknown
- 1987-09-23 DK DK500887A patent/DK167319B1/da not_active IP Right Cessation
- 1987-09-23 CA CA000547616A patent/CA1286285C/en not_active Expired - Lifetime
- 1987-09-23 NO NO873969A patent/NO169717C/no not_active IP Right Cessation
- 1987-09-23 PT PT85773A patent/PT85773B/pt not_active IP Right Cessation
- 1987-09-23 SU SU874203390A patent/SU1517764A3/ru active
- 1987-09-23 FI FI874152A patent/FI86853C/fi not_active IP Right Cessation
- 1987-09-23 HU HU874281A patent/HU196810B/hu not_active IP Right Cessation
- 1987-09-24 KR KR1019870010566A patent/KR920003902B1/ko not_active Expired
- 1987-10-15 AT AT0273187A patent/AT389311B/de not_active IP Right Cessation
-
1991
- 1991-01-03 GR GR90400968T patent/GR3001274T3/el unknown
-
1993
- 1993-02-11 SG SG153/93A patent/SG15393G/en unknown
- 1993-04-29 HK HK420/93A patent/HK42093A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |