KR880003955A - 페니실린 유도체의 수화물 및 그 제조방법 - Google Patents

페니실린 유도체의 수화물 및 그 제조방법 Download PDF

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Publication number
KR880003955A
KR880003955A KR870010566A KR870010566A KR880003955A KR 880003955 A KR880003955 A KR 880003955A KR 870010566 A KR870010566 A KR 870010566A KR 870010566 A KR870010566 A KR 870010566A KR 880003955 A KR880003955 A KR 880003955A
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South Korea
Prior art keywords
propionamido
thia
acetamido
heptane
oxo
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KR870010566A
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English (en)
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KR920003902B1 (ko
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스스무 오오시로
마사루 세누마
미쓰요시 와가쓰마
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아다찌 게이지로오
다나베 세이야꾸 가부시기가이샤
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Publication of KR880003955A publication Critical patent/KR880003955A/ko
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Publication of KR920003902B1 publication Critical patent/KR920003902B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/18—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

페니실린 유도체의 수화물 및 그 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1 도는 실시예 1의 적외선 스펙트럼을 나타낸다.

Claims (5)

  1. (2S, 5R, 6R)-6-{(2R)-2-[(2R)-2-아미노-3-(N-메틸-카르바모일)프로피온아미도]-2-(p-하이드록시페닐)아세트아미도}-3,3-디메틸-7-옥소-4-티아-1-아자비사이클로[3.2.0]헵탄-2-카르복시산 3수화물.
  2. (2S, 5R, 6R)-6-{(2R)-2-[(2R)-2-아미노-3-(N-메틸카르바모일)프로피온아미도]-2-(p-하이드록시페닐)아세트아미도}-3,3-디메틸-7-옥소-4-티아-1-아자비사이클로[3.2.0]헵탄-2-카르복시산 또는 그 염의 용액을 액체매질 중에서 pH 3 내지 6을 조절하고 결정화하여, (2S, 5R, 6R)-6-{(2R)-2-[(2R)-2-아미노-3-(N-메틸카르바모일)프로피온아미도]-2-(p-하이드록시페닐)-아세트아미도}-3,3-디메틸-7-옥소-4-티아-1-아자비사이클로[3.2.0]헵탄-2-카르복시산 3수화물을 제조하는 방법.
  3. 제 2 항에 있어서, pH를 3.5 내지 5.5.로 조절하는 방법.
  4. 제 2 항 또는 제 3 항에 있어서, 액체매질이 물, 저급알칸올 용액 또는 저급알칸온 용액인 방법.
  5. 제 4 항에 있어서, 냉각처리 또흔 용액의 농축 또는 물 혼화성 유기용매를 가하여 결정화시키는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870010566A 1986-09-24 1987-09-24 페니실린 유도체의 수화물 및 그 제조방법 KR920003902B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP226423 1986-09-24
JP61226423A JPS6379888A (ja) 1986-09-24 1986-09-24 ペニシリン誘導体の安定型水和物

Publications (2)

Publication Number Publication Date
KR880003955A true KR880003955A (ko) 1988-05-31
KR920003902B1 KR920003902B1 (ko) 1992-05-18

Family

ID=16844890

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870010566A KR920003902B1 (ko) 1986-09-24 1987-09-24 페니실린 유도체의 수화물 및 그 제조방법

Country Status (24)

Country Link
US (1) US4866170A (ko)
EP (1) EP0261823B1 (ko)
JP (1) JPS6379888A (ko)
KR (1) KR920003902B1 (ko)
CN (1) CN1021225C (ko)
AT (2) ATE59655T1 (ko)
AU (1) AU592467B2 (ko)
CA (1) CA1286285C (ko)
DE (1) DE3766921D1 (ko)
DK (1) DK167319B1 (ko)
ES (1) ES2026545T3 (ko)
FI (1) FI86853C (ko)
GR (1) GR3001274T3 (ko)
HK (1) HK42093A (ko)
HU (1) HU196810B (ko)
IE (1) IE60042B1 (ko)
IL (1) IL83786A (ko)
MY (1) MY102553A (ko)
NO (1) NO169717C (ko)
PH (1) PH23644A (ko)
PT (1) PT85773B (ko)
SG (1) SG15393G (ko)
SU (1) SU1517764A3 (ko)
ZA (1) ZA876739B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5375123A (en) * 1993-02-05 1994-12-20 Telefonakitebolaget L. M. Ericsson Allocation of channels using interference estimation
US6473602B1 (en) 1996-10-28 2002-10-29 Ericsson Inc. Mobile assisted handoff in radiocommunication systems
PE20000879A1 (es) * 1998-04-29 2000-09-23 Dsm Nv METODO PARA CRISTALIZAR UN ANTIBIOTICO ß-LACTAMICO
KR101879756B1 (ko) * 2016-11-30 2018-08-17 주식회사 지앤지비 욕실용 난방기

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6705789A (ko) * 1967-03-08 1968-09-09
GB1241844A (en) * 1968-08-23 1971-08-04 Beecham Group Ltd Penicillins
US4053609A (en) * 1975-09-12 1977-10-11 Tanabe Seiyaku Co., Ltd. Penicillins and processes for preparing the same
JPS5640686A (en) * 1979-09-11 1981-04-16 Tanabe Seiyaku Co Ltd Purification of penicillin derivative

Also Published As

Publication number Publication date
HUT45263A (en) 1988-06-28
PT85773A (en) 1987-10-01
FI874152A (fi) 1988-03-25
IL83786A (en) 1991-11-21
PT85773B (pt) 1990-07-31
EP0261823A1 (en) 1988-03-30
FI86853C (fi) 1992-10-26
ATA273187A (de) 1989-04-15
ES2026545T3 (es) 1992-05-01
AT389311B (de) 1989-11-27
DE3766921D1 (de) 1991-02-07
EP0261823B1 (en) 1991-01-02
PH23644A (en) 1989-09-27
AU592467B2 (en) 1990-01-11
AU7882787A (en) 1988-03-31
IE872346L (en) 1988-03-14
NO169717C (no) 1992-07-29
HU196810B (en) 1989-01-30
IL83786A0 (en) 1988-02-29
NO169717B (no) 1992-04-21
MY102553A (en) 1992-07-31
JPS6379888A (ja) 1988-04-09
JPH0448795B2 (ko) 1992-08-07
DK500887A (da) 1988-03-25
ZA876739B (en) 1988-03-14
KR920003902B1 (ko) 1992-05-18
DK500887D0 (da) 1987-09-23
NO873969L (no) 1988-03-25
CN87106308A (zh) 1988-04-13
HK42093A (en) 1993-05-07
DK167319B1 (da) 1993-10-11
IE60042B1 (en) 1994-05-18
FI874152A0 (fi) 1987-09-23
FI86853B (fi) 1992-07-15
SU1517764A3 (ru) 1989-10-23
NO873969D0 (no) 1987-09-23
US4866170A (en) 1989-09-12
SG15393G (en) 1993-04-16
CA1286285C (en) 1991-07-16
CN1021225C (zh) 1993-06-16
GR3001274T3 (en) 1992-08-25
ATE59655T1 (de) 1991-01-15

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