CN102119162B - 二氮杂咔唑及其使用方法 - Google Patents

二氮杂咔唑及其使用方法 Download PDF

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Publication number
CN102119162B
CN102119162B CN200980131217.3A CN200980131217A CN102119162B CN 102119162 B CN102119162 B CN 102119162B CN 200980131217 A CN200980131217 A CN 200980131217A CN 102119162 B CN102119162 B CN 102119162B
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compound
formula
compounds
group
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Expired - Fee Related
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CN200980131217.3A
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English (en)
Chinese (zh)
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CN102119162A (zh
Inventor
黑兹尔.J.戴克
伊曼纽拉.甘西亚
刘易斯.J.加扎德
西蒙.C.古达克里
约瑟夫.P.利西卡托斯
卡卢姆.麦克劳德
卡伦.威廉斯
陈慧芬
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200980131217.3A 2008-06-11 2009-06-10 二氮杂咔唑及其使用方法 Expired - Fee Related CN102119162B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6075008P 2008-06-11 2008-06-11
US61/060,750 2008-06-11
US14800409P 2009-01-28 2009-01-28
US61/148,004 2009-01-28
PCT/US2009/003481 WO2009151589A1 (en) 2008-06-11 2009-06-10 Diazacarbazoles and methods of use

Publications (2)

Publication Number Publication Date
CN102119162A CN102119162A (zh) 2011-07-06
CN102119162B true CN102119162B (zh) 2014-10-08

Family

ID=41066268

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980131217.3A Expired - Fee Related CN102119162B (zh) 2008-06-11 2009-06-10 二氮杂咔唑及其使用方法

Country Status (12)

Country Link
US (1) US20110124654A1 (https=)
EP (1) EP2324024B1 (https=)
JP (2) JP5677945B2 (https=)
KR (2) KR20110015699A (https=)
CN (1) CN102119162B (https=)
AU (1) AU2009258115B2 (https=)
BR (1) BRPI0909957A2 (https=)
CA (1) CA2726114A1 (https=)
ES (1) ES2392489T3 (https=)
IL (1) IL209548A (https=)
MX (1) MX2010013606A (https=)
WO (1) WO2009151589A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110015699A (ko) * 2008-06-11 2011-02-16 제넨테크, 인크. 디아자카르바졸 및 사용 방법
RU2017127088A (ru) 2010-11-16 2019-02-04 Эррэй Биофарма Инк. Комбинация ингибиторов чекпойнт-киназы 1 и ингибиторов киназы wee 1
GB201201566D0 (en) * 2012-01-30 2012-03-14 Vernalis R&D Ltd New chemical compounds
SG11201406818VA (en) * 2012-04-23 2014-11-27 Genentech Inc Intermediates and processes for preparing compounds
WO2014116859A1 (en) * 2013-01-23 2014-07-31 The University Of Chicago Methods and compositions for inhibiting human copper trafficking proteins atox1 and ccs
CN112472699A (zh) 2013-07-26 2021-03-12 种族肿瘤学公司 改善比生群及衍生物的治疗益处的组合方法
CN105358558B (zh) 2013-10-08 2017-09-26 豪夫迈·罗氏有限公司 作为tau‑pet‑配体的二氮杂咔唑衍生物
JP6840931B2 (ja) * 2015-03-09 2021-03-10 東ソー株式会社 縮環芳香族化合物の製造方法
US20170067946A1 (en) 2015-06-08 2017-03-09 Zac WHEELER Monitoring system with low power usage
RU2019102647A (ru) 2016-07-01 2020-08-03 Г1 Терапьютикс, Инк. Антипролиферационные средства на основе пиримидина
MX375720B (es) 2016-09-09 2025-03-04 Hoffmann La Roche Proceso para preparacion de 2-(6-nitropiridin-3-il)-9h-dipirido[2,3-beta;3',4'-d]pirrol.
WO2019168874A1 (en) 2018-02-27 2019-09-06 The Research Foundation For The State University Of New York Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
KR20230012547A (ko) 2020-05-19 2023-01-26 쥐원 쎄라퓨틱스, 인크. 의학적 장애의 치료를 위한 시클린-의존성 키나제 억제 화합물
CN115572282B (zh) * 2021-07-05 2024-07-09 华东理工大学 含芳杂环结构的吡唑酰胺类化合物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060264493A1 (en) * 2003-02-17 2006-11-23 Ermes Vanotti Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2007044779A1 (en) * 2005-10-07 2007-04-19 Takeda San Diego, Inc. Kinase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1054039B (zh) * 2000-03-15 2010-04-16 萨诺费－阿文蒂斯德国有限公司 取代的β-咔啉
EP1268477B1 (en) 2000-03-15 2010-04-21 Sanofi-Aventis Deutschland GmbH Substituted beta-carbolines with ikb-kinase inhibiting activity
KR100774855B1 (ko) * 2000-04-27 2007-11-08 아스텔라스세이야쿠 가부시키가이샤 축합 헤테로아릴 유도체
US6608053B2 (en) * 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
PE20060526A1 (es) * 2004-06-15 2006-07-13 Schering Corp Compuestos triciclicos como antagonistas de mglur1
US8618121B2 (en) 2007-07-02 2013-12-31 Cancer Research Technology Limited 9H-pyrimido[4,5-B]indoles, 9H-pyrido[4',3':4,5]pyrrolo[2,3-D]pyridines, and 9H 1,3,6,9 tetraaza-fluorenes as CHK1 kinase function inhibitors
KR20110015699A (ko) * 2008-06-11 2011-02-16 제넨테크, 인크. 디아자카르바졸 및 사용 방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060264493A1 (en) * 2003-02-17 2006-11-23 Ermes Vanotti Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2007044779A1 (en) * 2005-10-07 2007-04-19 Takeda San Diego, Inc. Kinase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Masahiko Hayakawa et al..Synthesis and biological evaluation of pyrido[30’,20’:4,5]furo[3,2-d] pyrimidine derivatives as novel PI3 kinase p110a inhibitors.《Bioorganic & Medicinal Chemistry Letters》.2007,第17卷2438-2442. *

Also Published As

Publication number Publication date
EP2324024B1 (en) 2012-09-26
CA2726114A1 (en) 2009-12-17
ES2392489T3 (es) 2012-12-11
KR101764556B1 (ko) 2017-08-02
IL209548A (en) 2014-03-31
WO2009151589A1 (en) 2009-12-17
JP2011522888A (ja) 2011-08-04
AU2009258115B2 (en) 2015-01-29
IL209548A0 (en) 2011-01-31
BRPI0909957A2 (pt) 2016-04-19
AU2009258115A1 (en) 2009-12-17
KR20160074680A (ko) 2016-06-28
AU2009258115A2 (en) 2011-05-12
MX2010013606A (es) 2010-12-21
JP5677945B2 (ja) 2015-02-25
EP2324024A1 (en) 2011-05-25
JP2014196309A (ja) 2014-10-16
US20110124654A1 (en) 2011-05-26
CN102119162A (zh) 2011-07-06
KR20110015699A (ko) 2011-02-16

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