CA2726114A1 - Diazacarbazoles and methods of use - Google Patents

Diazacarbazoles and methods of use Download PDF

Info

Publication number
CA2726114A1
CA2726114A1 CA2726114A CA2726114A CA2726114A1 CA 2726114 A1 CA2726114 A1 CA 2726114A1 CA 2726114 A CA2726114 A CA 2726114A CA 2726114 A CA2726114 A CA 2726114A CA 2726114 A1 CA2726114 A1 CA 2726114A1
Authority
CA
Canada
Prior art keywords
alkyl
cr14r15
groups
heterocyclyl
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2726114A
Other languages
English (en)
French (fr)
Inventor
Hazel Joan Dyke
Emanuela Gancia
Lewis J. Gazzard
Simon Charles Goodacre
Joseph P. Lyssikatos
Calum Macleod
Karen Williams
Huifen Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CA2726114A1 publication Critical patent/CA2726114A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2726114A 2008-06-11 2009-06-10 Diazacarbazoles and methods of use Abandoned CA2726114A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6075008P 2008-06-11 2008-06-11
US61/060,750 2008-06-11
US14800409P 2009-01-28 2009-01-28
US61/148,004 2009-01-28
PCT/US2009/003481 WO2009151589A1 (en) 2008-06-11 2009-06-10 Diazacarbazoles and methods of use

Publications (1)

Publication Number Publication Date
CA2726114A1 true CA2726114A1 (en) 2009-12-17

Family

ID=41066268

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2726114A Abandoned CA2726114A1 (en) 2008-06-11 2009-06-10 Diazacarbazoles and methods of use

Country Status (12)

Country Link
US (1) US20110124654A1 (https=)
EP (1) EP2324024B1 (https=)
JP (2) JP5677945B2 (https=)
KR (2) KR101764556B1 (https=)
CN (1) CN102119162B (https=)
AU (1) AU2009258115B2 (https=)
BR (1) BRPI0909957A2 (https=)
CA (1) CA2726114A1 (https=)
ES (1) ES2392489T3 (https=)
IL (1) IL209548A (https=)
MX (1) MX2010013606A (https=)
WO (1) WO2009151589A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0909957A2 (pt) * 2008-06-11 2016-04-19 Genentech Inc "composto, composição farmacêutica, método de inibir o crescimento anormal de células ou de tratar um distúrbio hiperproliferativo em um mamífero, método de tratamento do câncer em um mamífero"
ES2621857T3 (es) 2010-11-16 2017-07-05 Array Biopharma, Inc. Combinación de inhibidores de la cinasa 1 de punto de control e inhibidores de la cinasa WEE1
GB201201566D0 (en) * 2012-01-30 2012-03-14 Vernalis R&D Ltd New chemical compounds
AR090789A1 (es) * 2012-04-23 2014-12-10 Genentech Inc Intermediarios y procesos para la preparacion de compuestos
WO2014116859A1 (en) * 2013-01-23 2014-07-31 The University Of Chicago Methods and compositions for inhibiting human copper trafficking proteins atox1 and ccs
CN105764501A (zh) 2013-07-26 2016-07-13 现代化制药公司 改善比生群治疗效益的组合物
JP6194416B2 (ja) 2013-10-08 2017-09-06 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ タウ−ｐｅｔリガンドとしてのジアザカルバゾール誘導体
JP6840931B2 (ja) * 2015-03-09 2021-03-10 東ソー株式会社 縮環芳香族化合物の製造方法
US20170067946A1 (en) 2015-06-08 2017-03-09 Zac WHEELER Monitoring system with low power usage
EP3858835A1 (en) 2016-07-01 2021-08-04 G1 Therapeutics, Inc. Pyrimidine-based antiproliferative agents
WO2018046428A1 (en) 2016-09-09 2018-03-15 F. Hoffmann-La Roche Ag Process for preparation of 2-(6-nitropyridin-3-yl)-9h-dipyrido[2,3-b;3',4'-d]pyrrole
WO2019168874A1 (en) 2018-02-27 2019-09-06 The Research Foundation For The State University Of New York Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
ES3048084T3 (en) 2020-05-19 2025-12-09 Pharmacosmos Holding As Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders
CN115572282B (zh) * 2021-07-05 2024-07-09 华东理工大学 含芳杂环结构的吡唑酰胺类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0300894A3 (en) * 2000-03-15 2008-05-28 Sanofi Aventis Deutschland Substituted beta-carbolines, process for their preparation, pharmaceutical compositions containing them and their use
WO2001068648A1 (en) 2000-03-15 2001-09-20 Aventis Pharma Deutschland Gmbh Substituted beta-carbolines with ikb-kinase inhibiting activity
US6608053B2 (en) * 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
CN1186324C (zh) * 2000-04-27 2005-01-26 山之内制药株式会社 稠合杂芳基衍生物
BRPI0407544A (pt) * 2003-02-17 2006-02-14 Pharmacia Italia Spa derivados de pirazol tetracìclicos como inibidores da cinase, processo para a sua preparação e composições farmacêuticas que os compreendem
AR049300A1 (es) * 2004-06-15 2006-07-12 Schering Corp Compuestos triciclicos antagonistas de mglur1 como agentes terapeuticos
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2170886A1 (en) 2007-07-02 2010-04-07 Cancer Research Technology Limited 9h-pyrimido[4,5-b]indoles, 9h-pyrido[4',3':4,5]pyrrolo[2,3-d]pyridines, and 9h-1,3,6,9-tetraaza-fluorenes as chk1 kinase function inhibitors
BRPI0909957A2 (pt) * 2008-06-11 2016-04-19 Genentech Inc "composto, composição farmacêutica, método de inibir o crescimento anormal de células ou de tratar um distúrbio hiperproliferativo em um mamífero, método de tratamento do câncer em um mamífero"

Also Published As

Publication number Publication date
AU2009258115B2 (en) 2015-01-29
EP2324024B1 (en) 2012-09-26
KR20160074680A (ko) 2016-06-28
BRPI0909957A2 (pt) 2016-04-19
JP2011522888A (ja) 2011-08-04
JP5677945B2 (ja) 2015-02-25
KR101764556B1 (ko) 2017-08-02
JP2014196309A (ja) 2014-10-16
AU2009258115A2 (en) 2011-05-12
WO2009151589A1 (en) 2009-12-17
ES2392489T3 (es) 2012-12-11
CN102119162B (zh) 2014-10-08
EP2324024A1 (en) 2011-05-25
IL209548A0 (en) 2011-01-31
MX2010013606A (es) 2010-12-21
IL209548A (en) 2014-03-31
KR20110015699A (ko) 2011-02-16
AU2009258115A1 (en) 2009-12-17
US20110124654A1 (en) 2011-05-26
CN102119162A (zh) 2011-07-06

Similar Documents

Publication Publication Date Title
AU2009258115B2 (en) Diazacarbazoles and methods of use
US8293763B2 (en) 8-anilinoimidazopyridines and their use as anti-cancer and/or anti-inflammatory agents
US7923456B2 (en) 5-anilinoimidazo[1,5-a]-pyridines inhibitors of MEK kinase
US7893085B2 (en) Aza-benzothiophenyl compounds and methods of use
AU2009258124B2 (en) Diazacarbazoles and methods of use
EP2164850B1 (en) N-substituted azaindoles and methods of use
US20110130406A1 (en) Pyrazolo-pyridines as tyrosine kinase inhibitors
CA2782213A1 (en) 1,7-diazacarbazoles and their use in the treatment of cancer
US20150368244A1 (en) Diazacarbazoles and methods of use
EP2300457B1 (en) Substituted pyrroles and methods of use
HK40091719A (zh) 取代的稠杂环化合物及其制备方法与应用
HK40091719B (zh) 取代的稠杂环化合物及其制备方法与应用

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20140527

FZDE Discontinued

Effective date: 20170109