CN102058759A - Medicinal tea prepared from Chinese medicinal materials by microbial fermentation - Google Patents
Medicinal tea prepared from Chinese medicinal materials by microbial fermentation Download PDFInfo
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Abstract
The invention relates to medicinal tea prepared from Chinese medicinal materials by microbial fermentation, belonging to the technical field of traditional Chinese medicine. The medicinal tea is characterized in that the extractive solution of traditional Chinese medicine or Chinese medicinal materials with bacteriostatic action are processed by fermentation as fermentation solution, and prepared into tea for decoction or baled tea and bag tea for infusion; the traditional Chinese medicine with bacteriostatic action are traditional Chinese medicine or Chinese medicinal materials with known bacteriostatic action, such as garlic, ginger, pricklyash peel, turmeric, Salvia miltiorrhiza, honeysuckle flower, isatis root, isatis leaf, Chinese gallnut, Resina Toxicodendri, giant knotweed, Magnolia officinalis, chaulmoogratree seed, coptis root, Sophora flavescens, Forsythia suspensa, Rheum officinale, rehmannia root, common anemarrhena rhizome and Allium macrostemon. The medicinal tea contains tea leaves or not, as well as other traditional Chinese medicine, and can be decocted or infused. The medicinal tea has the characteristics of high compliance in use, and high utilization ratio of medicinal materials. The medicinal tea has the functions in dispelling wind, relieving exterior syndrome, removing dampness by diuresis and normalizing function of the stomach and spleen, and can be used for treating common cold, sunstroke, fever, abdominal pain, aching body, vomiting and diarrhea.
Description
Technical field
The present invention relates to a kind of medicinal tea Chinese medicine, particularly a kind of medicinal tea Chinese medicine of concocting with microbe fermentation method belongs to medicinal tea Chinese drug preparation technique field.
Background technology
Chinese medicine is the rarity of the Chinese nation, in the history that China people fight back the disease, play an important role, but in modern age, China makes progress slower aspect the modernization of Chinese medicine, except Chinese medical theory and modern scientific theory can not integrate with well, the research means backwardness also is one of reason, makes Chinese medicine fail fully to be accepted by international community.The modernization of the processed means of Chinese medicine also should be the important content of the modernization of Chinese medicine, is particular about very much as Chinese medicine and concocts, and reaches purposes such as improving drug effect, the change property of medicine, reduction toxic and side effects by the process of preparing Chinese medicine.Microorganism has the ability of very powerful decomposition and inversion material, and can produce abundant secondary metabolite, concoct Chinese medicine by microbial growth metabolism and vital movement, can change the property of medicine by a larger margin than the process of preparing Chinese medicine means of general physical or chemistry, improve curative effect, reduce toxic and side effects, enlarge indication.Because fungus has characteristics such as kind is many, secondary metabolite is many, condition of culture is fairly simple in microorganism, be the major function bacterium of fermented tcm.
The medicinal history of microorganism is very long, fungal drug is the important component part of China's traditional medicine, China also is the country that utilizes fungus to prevent and cure diseases the earliest in the world, in the period of the Eastern Han Dynasty, become in first materia medica Shennong's Herbal of China of book, just have medicinal fungis such as Ganoderma, Poria, Polyporus, Omphalia to do special argumentation respectively, these medicines are continued to use so far and are not waned.From these fungus Chinese medicines, be separated to corresponding pure culture; some has been carried out the artificial growth thing and has replaced wild product, can not the artificial growth sporophore, also can replace by cultivating mycelium; fully satisfied the requirement of pharmacy practice, also made contribution for environmental conservation and economic development.Over nearly 50 years, Chinese scholars is being furtherd investigate aspect medicinal microorganism classification, chemistry, pharmacology, clinical medicine, galenic pharmacy and genetic breeding, cultivation domestication, the fermentation culture, obtained good effect, in health product and drug development, occupied very outstanding position as microbial ecological agent, Ganderma lucidum, Cordyceps, Armillaria mellea, the false capsule yeast of A Shi, Hypocrella bambusae (Bet Br). Sace etc.Because microbial metabolic products has various unique chemical structure and physiologically active, therefore, receives pharmacy worker's very big concern.
Fermentation also is one of important method of concocting of Chinese medicine processing, is the microbial fermenters of Radix Notoginseng as the main component of Pien Tze Huang, and Massa Medicata Fermentata, Agalloch eaglewood leaven, Semen Sojae Preparatum, Pinellia leaven, Monas cuspurpureus Went, Fructus Hordei Germinatus also all are the medicines that forms by fermentation.In a sense, Cordyceps is that the Hepialus armorieanus Oberthur larva forms through the Cordyceps fermentation, and Bombyx Batryticatus also is that silkworm forms through muscardine infection fermentation.These classical medicines all are to have produced new pharmacologically active behind microbial fermentation, and wherein Cordyceps is very famous and precious Chinese medicine.These kinds all are to utilize the natural strain fermentation of nature, generally mostly be mycete, yeast, antibacterial etc., because strain is impure, specific aim is not strong, can not utilize the performance of modern study achievement directed change medicine or carry out autotelic combination according to the characteristic between the medicine consciously, the microbe species scope of Jie Ruing has been subjected to very big restriction simultaneously, also can not as required several microorganism combinations be seeded in together; On the other hand, concerning the microorganism that those are not preponderated at occurring in nature, the growth conditions requirement is relatively stricter, just can not on medicine, grow.This has just greatly limited action of microorganisms.In addition, it is also indeterminate whether can to fall into harmful bacterium, so the latent effectiveness of microorganism in medicine also do not brought into play to greatest extent.
Microorganism is the strong instrument of Chinese medicine fermentation.Microorganism can produce various bioactive substances in growth course, and is easy to industrialization.Many biological products are all produced by microbial fermentation in the modern industry, as enzyme miscellaneous, antibiotic.Enzyme is the basis that all organisms carry out vital movement, it can make complicated chemical reaction finish rapidly at normal temperatures and pressures, in growth course, produce neutral protease, alkaline protease, acid protease, cellulase, hemicellulase, pectase, tannase, esterification enzyme, amidase, amylase and saccharifying enzyme etc. as aspergillus oryzae, yeast can produce saccharase, amylase, lipase, zymase etc. when fermentation, existing endocellular enzyme in these enzymes also has exoenzyme; Existing synzyme also has catabolic enzyme.Some microorganism can be secreted tens kinds of exoenzymes in culture medium in growth course, the endocellular enzyme that vital movement produced is carried out in microorganism to be had hundreds and thousands of especially, these abundant and powerful enzyme systems are material bases of Chinese medicine generation chemical reaction, the composition decomposition and inversion of medicine can be formed new composition, these new components are exactly the material base that new active medicine screens.Microorganism that Here it is can be used for fermenting and concoct the rationale of Chinese medicine, has become a kind of method of Chinese medicine processing as enzyme process, and according to relevant, before the extraction berberine, medical material can improve the yield of berberine after cellulase carries out enzymolysis.On the other hand, because microorganism also can form rich and varied secondary metabolite, they some itself be exactly the effect excellent drug; Or be precursor with the effective ingredient in the Chinese medicine, can form new chemical compound through the metabolism of microorganism, or the secondary metabolite of microorganism and the composition in the Chinese medicine react and form new chemical compound.The microorganism secondary metabolite can with Effective Components of Chinese Herb generation compound recipe, synergism.Microorganism also might produce new metabolic response in the special environment of Chinese medicine, because the material of Chinese medicine may have promotion or inhibitory action to microbial growth and metabolism, thereby change the metabolic pathway of microorganism, thereby form new composition or change the mutual ratio of each composition.The decomposition of microorganism might be decomposed the noxious substance in the Chinese medicine, thereby reduces the toxic and side effects of medicine, can slough noxious substance as rapeseed cake, cottonseed cake behind microbial fermentation, thereby be used for the domestic animal of feeding; Original non-digestible material is become be easy to absorb, behind microbial fermentation, digestibility can improve exponentially as animal blood.Because what growth of microorganism mainly consumed is conventional substances such as vegeto-animal protein, sugar, might inspissation be arranged to effective ingredient, extracting dioscin as fermentation method is exactly by the starch in the fermentation removal Rhizoma Dioscoreae.With regard to microbial ecological agent, probiotics itself is exactly good medicine, as bacillus bifidus.The easy mutation of microorganism can be as required, and the utilization modern biotechnology is transformed microorganism, makes it to be more suitable for the needs of Chinese medicine fermentation.Modern biotechnology at first finds application in microbial body, also is the most sophisticated fields of technology such as genetic engineering.
Microbe groups provides competent choice for the Chinese medicine fermentation.According to statistics, the microorganism of having found at present that can produce antibacterium, antiviral product kind surplus only fungus just reaches 200,200 kinds of antineoplastic funguses.According to national natural resources of Chinese medicinal materials generaI investigation statistics, China's medicinal fungi have 41 sections, 110 belong to, 298 kinds, account for algae, mushroom, lichens etc. and belong to 63.8% of 467 kinds of medicinal plants such as low together, be to plant the maximum class of number in the medicinal plants such as low.The bio-diversity of microorganism provides abundant available bacterial strain for us, and different microorganisms has different characteristics, may have different effects in the Chinese medicine fermentation.But different microorganisms produces similarly biological active substances substantially sometimes, isolated nearly hundreds of kind fungus as people from Cordyceps, but the effect of the Cordyceps that they produced all is similar; Different culture medium also can produce the difference of the property of medicine after same microbe groups fermentation process, as fermentation during Semen Sojae Preparatum, with system, the property of medicine is relatively cold and cool with Folium Mori, Herba Artemisiae Annuae, is applicable to that affection due to external wind and heat or epidemic febrile disease levy from the beginning of it; Be equal to system with Herba Ephedrae, Folium Perillae, the relatively hot temperature of the property of medicine is applicable to levying of affection of exogenous wind-cold.
Microorganism has many-sided pharmacological action.The function of the active component of finding in the microorganism is many-sided, has become the key areas of finding new drug.Now, except antibiotic such as antibiotic, antitumor, the discovery of non-antimicrobial biological active substances is more and more, as: immunosuppressant, blood fat reducing, antioxidation, receptor antagonist and specificity enzyme inhibitor etc.Toadstool also is a class contains the strong effect effect to the people a mushroom, and extremely a spot of active substance just can cause people's vigorous reaction, as if the relevant Chinese medicine that ferments with these mushrooms, may receive beyond thought effect.Contain neurotoxin as malicious fly Amanita fuliginea, can cause people's spiritual hallucination, the hobby of eating Agaric the America and Europe in addition.Adopt this class toadstool corresponding Chinese medicine against drug dependence that ferments, might be helpful to exploitation drug rehabilitation class medicine.
Concerning the research of a certain concrete fermented tcm, mainly need carry out following work: 1) strengthen the strain improvement work of functional microorganism; 2) Chinese medicine fermentation technique and equipment research; 3) prescription of fermented tcm and pharmacology activity research; 4) compound microorganism ferments technical research; 5) set up effective screening model; 6) use the modern chemical analysis technology, set up the analyzing and testing hands section of rapid sensitive; 7) in research fermented tcm process, how to implement the guidance of theory of Chinese medical science and other new results of absorption modern Chinese medicine.In a word, utilize microbial fermentation Chinese medicine to have vast potential for future development, also possessed the relevant condition of development, be sophisticated opportunity.Domesticly begun relevant research work in this respect, and obtained certain progress as the Yunnan Prov. Inst. of Microbiology.Can predict, by effort, utilize the modern biotechnology fermented tcm to provide new technological means to expansion treatment by Chinese herbs scope, dosage form improvement, initiative new drug aspect, for absorbing modern scientific and technical result, Chinese medicine provides new way, inject new content and vigor to Chinese medicine research, play the fresh content that further impetus microbial fermentation Chinese medicine should become Chinese medicine research for Chinese medicine goes to the world, benefits the whole mankind.
More than be the technical background of the microbial fermentation aspect of Chinese medicine, be the Chinese medicine medicinal tea that research is concocted with microbe fermentation method, also need learn about development history, the prior art situation of Chinese medicine medicinal tea.
China is the native place of tea, plants the history in existing more than 4000 year of tea.In the Shennong's Herbal before more than 2000 years just with tea as important simply medicine, three states' Wei " WU Pu Bencao " are also on the books.All record multiple " tea-drinking agent " in the books such as principle of Correct Diet of " medical secrets of official " of the Tang Dynasty Wang Tao, " prescriptions worth thousand gold " of Sun Simiao and Yuan Dynasty's Husihui.Tang's CHEN Zang-Qi supplement to the Herbal is said: " all medicines are the medicine of each disease, and tea is the medicine of all kinds of diseases and ailments." Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica says: " and tea, bitter and tremble with fear, the yin aspect of yin sinks and also falls also, can pathogenic fire reducing, fire is all kinds of diseases and ailments, interior supernatant falls in fire." Wang Ang of the Qing Dynasty says in essentials of Matea Medica: " drink tea and can separate food and drink, greasy, the poison that burns." modern age is according to the theory of Chinese medicine, thinks that tea can refreshment, the relieving restlessness of calming the nerves, last refresh oneself, clearing heart fire, the therapeutic method to keep the adverse QI flowing downwards helps digestion, and separates oil and goes to be bored with, and slakes thirst and help produce saliva diuresis antiinflammatory, heat-clearing and toxic substances removing, the stopping leak of relieving summer heat, expelling pathogenic wind from the body surface, preventing phlegm from forming and stopping coughing, tonification stomach function regulating, life lengthening.The benefit of drinking tea is a lot, and summarize and get up to have following 12 points: (1) can make the people inspire enthusiasm, and strengthens thinking, memory and motor capacity; (2) the energy allaying tiredness enhances metabolism, and the effect of keeping normal function such as heart, blood vessel, gastrointestinal is arranged; (3) dental caries there is very big benefit.Once investigation according to Britain shows, child's dental caries of often drinking tea can reduce 60%; (4) contain many trace element, and contain the indispensable trace element zinc of gravid woman the human body beneficial; (5) the inhibition effect of malignant tumors is arranged, the sudden change of anticancer significantly of drinking tea; (6) can suppress cell ageing, make people's life lengthening.The aging resistance effect of Folium Camelliae sinensis is more than 18 times of vitamin E; (7) can delay and prevent that tunica intima lipid speckle from forming, prevent arteriosclerosis, hypertension and cerebral thrombosis; (8) good fat-reducing and cosmetic result are arranged; (9) can prevent to have a strong impact on the cataract of old people's vision: the contained tannic acid of (10) Folium Camelliae sinensis can be killed various bacteria, thus can prevent and treat stomatitis, pharyngolaryngitis, and summer incident enteritis, dysentery etc.; (11) can protect people's hematopoietic function and keep the normal acid-base balance of blood; (12) preventing heatstroke.
Along with the reach of science, people find that the multiple composition in the Folium Camelliae sinensis all has good health care, therapeutic effect in secular clinical and research of preventing and curing diseases.Wherein contained protein, aminoacid, fat, carbohydrate, vitamin and mineral etc. all are the necessary nutritional labelings of human body.Tea medicine adapted helps to bring into play and strengthens the curative effect of medicine and be beneficial to medicine dissolution, absorption.Therefore, both at home and abroad from the eighties, risen one tea and treated heat.Medicated tea as Chinese medicine prevent and cure diseases, a big characteristic in the health care.
On the basis of development history, present situation and the developing direction of two big technology, the present invention has creatively invented Chinese medicine and has chosen the Chinese medicine processing method that flora has carried out orientation fermentation more than fully having studied, and has innovated the preparation method of orientation fermentation Chinese medicine medicinal tea.
Summary of the invention
The purpose of this invention is to provide a kind of medicinal tea Chinese medicine of concocting with microbe fermentation method, this medicinal tea Chinese medicine adopts in conjunction with Chinese medicine medicinal tea technology and microbial fermentation technology, create antibiotic Chinese medicine and select bacterium to prepare the technology of medicinal tea Chinese medicine, develop and improved form of Chinese drug variation technology and Chinese medicine processing technology.
In order to address the above problem, the technical solution adopted in the present invention is:
A kind of medicinal tea Chinese medicine of concocting with microbe fermentation method, this medicinal tea Chinese medicine are to make powder, be pressed into piece or make teabag after will having the Chinese crude drug extracting solution fermentation of bacteriostasis.
The above-mentioned Chinese crude drug with bacteriostasis is for having in the Chinese crude drug of bacteriostasis one or more in external bacterium culture test.
Selected scope of medication and optimization of C:
Folium Perillae 10-50g, Herba Moslae 10-50g, Radix Glycyrrhizae 30-100g, Rhizoma Cyperi 10-50g, Rhizoma Atractylodis 35-80g, Rhizoma Acori Graminei 10-30g, Cortex Magnoliae Officinalis (system) 20-60g, Rhizoma Et Radix Notopterygii 10-50g, Pericarpium Citri Reticulatae (system) 10-50g, Rhizoma Osmundae 10-50g, Radix Bupleuri 10-50g, Rhizoma Pinelliae (processed) 10-50g, Rhizoma Chuanxiong (processed with wine) 10-50g, Herba Menthae 10-35g, Fructus Aurantii 10-65g, Radix Mussaendae 40-65g, Radix Platycodonis 10-50g, Herba Schizonepetae 10-50g, Herba Pogostemonis 10-50g, Herba Ephedrae 0-20g, Folium Camelliae sinensis 20-80g, above medical material, pulverize separately become coarse powder, and (No. two sieves of whole mistakes (24 order) are less than 40% by No. four sieves (65 order), particle diameter 0.85～0.25mm, mixing is got Bulbus Allii or Rhizoma Zingiberis Recens 40-100g, preferably Rhizoma Zingiberis Recens, section, add 6-10 times of water gaging, decocted the extracting juice waste 0.5-2 hour, add in the above-mentioned medicinal material coarse powder, moistening is even, places fermentation 1-3 days, and (medicated powder is little to little Jiao with the slow fire stir-fry, the surface jaundice), drying is distributed into every bag of 6g or 12g, or makes teabag, or briquet, every clothes 6g or 12g, this medicinal tea has dispelling wind to relieve the exterior syndrome, dampness removing and in function, be used for four seasons Common Cold, the heatstroke heating, the acid of stomachache body, vomiting is had loose bowels.Antibacterial Chinese medicine scope of the present invention is an extension, and the dosage form form of expression is coarse powder tea, piece tea and teabag, and occupation mode is coarse powder and piece tea decoction method, and teabag directly brews repeatedly with boiled water, can brew at most 9 times.
Product of the present invention has dispelling wind to relieve the exterior syndrome, dampness removing and in function, be used to prevent and treat four seasons Common Cold, heatstroke heating, the acid of stomachache body, the preparation of the medicine of the vomiting effect of having loose bowels.Concrete experiment situation sees also embodiment.
The present invention with respect to the beneficial effect of prior art is:
1. the present invention adopts Chinese medicine processing technology and microbial fermentation processing technique to combine, and creates antibiotic Chinese medicine and selects bacterium to prepare the technology of medicinal tea Chinese medicine, develops and improved form of Chinese drug variation technology and Chinese medicine processing technology;
The present invention with its bacteriostasis of the strong Chinese medicine of bacteriostasis (material) fermented product a little less than.Otherwise easily right, Chinese medicine (material) fermented product its bacteriostasis weak with bacteriostasis is strong;
3. carry out fermentative microflora (a small bundle of straw, etc. for silkworms to spin cocoons on) with the Chinese medicine biocidal property, ferment to concoct and select bacterium, ingeniously complied with natural ecological balance rule, the stable flora height, the fermented product constant product quality, the coefficient of variation is little.
The specific embodiment
Below by embodiment the present invention is described in further details, these embodiment only are used for illustrating the present invention, do not limit the scope of the invention.
Embodiment 1
Get Herba Ephedrae 20g, Folium Perillae 50g, Herba Moslae 10g, Radix Glycyrrhizae 100g, Rhizoma Cyperi 10g, Rhizoma Atractylodis 35g, Rhizoma Acori Graminei 30g, Cortex Magnoliae Officinalis (system) 20g, Rhizoma Et Radix Notopterygii 50g, Pericarpium Citri Reticulatae (system) 10g, Rhizoma Osmundae 50g, Radix Bupleuri 10g, Rhizoma Pinelliae (processed) 10g, Rhizoma Chuanxiong (processed with wine) 10g, Herba Menthae 35g, Fructus Aurantii 10g, Radix Mussaendae 50g, Radix Platycodonis 10g, Herba Schizonepetae 10g, Herba Pogostemonis 10g, Folium Camelliae sinensis 30g, above medical material, pulverize separately becomes coarse powder, No. two sieves of whole mistakes (24 order), be less than 40% by No. four sieves (65 order), particle diameter 0.85～0.25mm, mixing, get Bulbus Allii 40g, section is added a cover, add the about 400g of water and decocted 2 hours, the waste extracting juice adds in the above-mentioned coarse powder, make and moisteningly evenly place fermentation 3 days, fry to little Jiao with slow fire, drying, briquet, every 6g, use the 1-2 piece at every turn, decocted every day 1-2 time 0.5 hour.
Embodiment 2
Get Folium Perillae 10g, Herba Moslae 50g, Radix Glycyrrhizae 30g, Rhizoma Cyperi 50g, Rhizoma Atractylodis 80g, Rhizoma Acori Graminei 10g, Cortex Magnoliae Officinalis (system) 60g, Rhizoma Et Radix Notopterygii 10g, Pericarpium Citri Reticulatae (system) 50g, Rhizoma Osmundae 10g, Radix Bupleuri 50g, Rhizoma Pinelliae (processed) 10-50g, Rhizoma Chuanxiong (processed with wine) 50g, Herba Menthae 35g, Fructus Aurantii 10g, Radix Mussaendae 40g, Radix Platycodonis 10g, Herba Schizonepetae 10g, Herba Pogostemonis 10g, Folium Camelliae sinensis 20g, above medical material, pulverize separately becomes coarse powder, and No. two sieves of whole mistakes 24 orders are less than 40% by No. four sieve 65 orders, particle diameter 0.85～0.25mm, mixing is got Rhizoma Zingiberis Recens 40g, preferably Rhizoma Zingiberis Recens is cut into slices, and adds the about 400g of water and decocts 2 hours, waste, extracting juice adds in the above-mentioned coarse powder, make and moisteningly evenly place fermentation 1 day, fry to little Jiao with slow fire, drying, every bag of 6g packing is also made teabag, each 1-2 bag.
Embodiment 3
Get Folium Perillae 10g, Herba Moslae 10g, Radix Glycyrrhizae 35g, Rhizoma Cyperi 10g, Rhizoma Atractylodis 35g, Rhizoma Acori Graminei 10g, Cortex Magnoliae Officinalis (system) 20g, Rhizoma Et Radix Notopterygii 10g, Pericarpium Citri Reticulatae (system) 10g, Rhizoma Osmundae 10g, Radix Bupleuri 10g, Rhizoma Pinelliae (processed) 50g, Rhizoma Chuanxiong (processed with wine) 10g, Herba Menthae 10g, Fructus Aurantii 65g, Radix Mussaendae 65g, Radix Platycodonis 50g, Herba Schizonepetae 50g, Herba Pogostemonis 50g, Folium Camelliae sinensis 80g, above medical material, pulverize separately becomes coarse powder, and No. two sieves of whole mistakes 24 orders are less than 40% by No. four sieve 65 orders, particle diameter 0.85～0.25mm, mixing is got Bulbus Allii 100g, section, add the about 600g of water and decocted waste, extracting juice 0.5 hour, add in the above-mentioned coarse powder, make moistening evenly, place fermentation 1 day, fry to little Jiao with slow fire, drying, promptly.
Embodiment 4
Get Folium Perillae 25g, Herba Moslae 25g, Radix Glycyrrhizae 50g, Rhizoma Cyperi 25g, Rhizoma Atractylodis 50g, Rhizoma Acori Graminei 15g, Cortex Magnoliae Officinalis (system) 40g, Rhizoma Et Radix Notopterygii 25g, Pericarpium Citri Reticulatae (system) 25g, Rhizoma Osmundae 25g, Radix Bupleuri 25g, Rhizoma Pinelliae (processed) 25g, Rhizoma Chuanxiong (processed with wine) 25g, Herba Menthae 15g, Fructus Aurantii 25g, Radix Mussaendae 50g, Radix Platycodonis 25g, Herba Schizonepetae 25g, Herba Pogostemonis 25g, Folium Camelliae sinensis 55g, above medical material, pulverize separately becomes coarse powder, No. two sieves of whole mistake 24 orders, be less than 40% by No. four sieves of 65 orders, particle diameter 0.85～0.25mm, mixing, get Rhizoma Zingiberis Recens 100g, preferably Rhizoma Zingiberis Recens is cut into slices, add water 600g, decocted waste 0.5 hour, extracting solution adds in the above-mentioned coarse powder, make moistening evenly, place fermentation 3 days, fry to little Jiao with slow fire, drying, promptly.
Embodiment 5
The product of embodiment 2,3 is got in the effect comparative experiments, has carried out following experiment:
With the contrast test of Rhizoma Zingiberis Recens, the external bacteriostasis of Bulbus Allii water extract, carry out external bacteriostasis comparative test by embodiment 2,3 contrivance decocting liquid then earlier.Its fungistatic effect of contrivance is unexpected.
Bulbus Allii (Allium sativum L.) belongs to Liliaceae biennial herb plant, is oblate spheroid or short conical, and the membranous firecoat of canescence or pale red is arranged outward, peel off scale leaf, in 6-10 garlic clove arranged, colyliform be born in scape around, the basal part of stem plate-like has most fibrous roots.A garlic clove outside is surrounded by the layer of transparent film, peels off film, promptly sees white, plump sappy scale.Strong garlic odour is arranged, and acrid in the mouth is peppery.Go into spleen, stomach, lung meridian.Have the stagnant gas of row, warming the spleen and stomach, the addiction that disappears is long-pending, detoxifcation, insecticidal action.Singly be used for the treatment of eating accumulation, coldness and pain in the epigastrium, edema distension, diarrhea, dysentery, malaria, pertussis, swollen ulcer drug, white bald tinea skin ulcer, snake bite and insect sting.Main chemical compositions is volatile oil, enzyme, sulfur glycoside, steroidal glycoside, peptide and amino acids and saccharide.Modern study shows that Bulbus Allii has pharmacologically active widely, and relevant with this test is the effect of its resisting pathogenic microbes, and its active substance is not clear, may be relevant with volatile oil, enzyme, sulfur glycoside, steroidal glycoside material.
Rhizoma Zingiberis Recens (Zingiber of officinal Rose) belongs to the Zingiberaceae herbaceous plant, and stem is the meat root stock, and axillalry bud is constantly mitogenetic to take place one, two, three ... inferior, secondary rhizome, the intensive one-tenth of growing thickly is block, and the aerial stem of plant is that sheath is embraced synthetic cauloid, high 70-100 cm, uprightly branch not.Leaf lanceolar tool sheath, green, leaf alternate, row's concentration two row.Rhizoma Zingiberis Recens blooms in the torrid zone, brightly yellowish green or redness, and seldom the result breeds with rhizome.Be irregular bulk, slightly flat, tool finger-like branch, long 4 ~ 18cm, thick 1 ~ 3cm.Surface yellowish-brown or taupe brown have link, and there are stem trace or bud in the branch top.Matter is crisp.Frangibility, section is light yellow, and the endodermis ring grain is obvious, and the dimension beam tube is dispersed in.Gas perfume (or spice) is special, and acrid in the mouth is peppery.Suffering, tepor; Return lung, spleen, stomach warp.Have the cold expelling of inducing sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing is used for anemofrigid cold, gastrofrigid vomiting, cold-phlegm cough.
Adopt Bulbus Allii, gingerade extract that escherichia coli, bacillus cereus, dysentery bacterium, four kinds of antibacterials of staphylococcus aureus are carried out fungistatic effect research, and Bulbus Allii, gingerade infusion be analyzed above four kinds of antibacterial fungistatic effects, relatively Rhizoma Zingiberis Recens, Bulbus Allii are to the bacteriostatic power of antibacterial, for the microbial fermentation flora selects to provide foundation.Every kind has its antimicrobial spectrum of Chinese medicine of bacteriostasis is different, gives birth to flora and suppresses flora according to ecological balance and every kind of specific living of Chinese medicine, and it is all different that the result is concocted in its fermentation.Therefore, the claimed Chinese medicine that bacteriostasis arranged of the present invention is used for the right of Chinese medicine fermentation process of preparing Chinese medicine method.Chinese medicine with bacteriostasis removes above-mentioned Bulbus Allii, Rhizoma Zingiberis Recens, also has Pericarpium Zanthoxyli, Radix Curcumae, Radix Salviae Miltiorrhizae, Flos Lonicerae, Radix Isatidis, Folium Isatidis, Galla Chinensis, universe lacquer, Rhizoma Polygoni Cuspidati, Cortex Magnoliae Officinalis, Da Wind, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Forsythiae, Radix Et Rhizoma Rhei, the Radix Rehmanniae, the Rhizoma Anemarrhenae, Bulbus Allii Macrostemonis etc.
The extracting solution preparation: get the Bulbus Allii peeling, Rhizoma Zingiberis Recens is cleaned, each 50g, and clean 1000ml flask is put in section respectively.Press 1:1 respectively, 1:6,1:10, the ratio of 1:15 adds sterilized water, and each reflux, extract, 0.5 ~ 2 hour is filtered, and Bulbus Allii, the ginger extract of getting the variable concentrations gradient after the filtration are standby, and above Concentraton gradient is made as A successively, and B, C, D handle number.Wherein A, C group was extracted 0.5 hour, and B, D group was extracted 2 hours.
Bacterium liquid preparation: get escherichia coli, bacillus cereus, dysentery bacterium, staphylococcus aureus strains tested test tube, draw 5 ml sterilized water, wash bacterium colony, and make its mix homogeneously, be mixed with and be no less than 50～100cfu/ml bacterium liquid with suction pipe, standby.
The preparation of culture medium: Carnis Bovis seu Bubali cream peptone culture medium: beef 3g, peptone 10 g, NaCl 5 g, agar 15 ~ 20 g add pure water and make 1000 ml, and pH 7. 0 ~ 20 min 7. sterilize for 2,121 ℃ times.
Bacteriostatic test: culture medium after sterilization 20 ml are poured into make flat board in the sterile petri dish.Draw 0.5mL bacterium liquid in plating medium with aseptic straw, pour one deck culture medium mixing more thereon into, bacteria suspension and culture medium are evenly distributed in the flat board.With aseptic card punch filter paper is broken into diameter 6 mm disks,, be immersed in Bulbus Allii, the ginger extract through sterilization, whenever folded 4, paste flat board, each common horizontalization plate 4 is folded.The culture dish that posts filter paper is inverted, in 30 ℃ of incubators, is cultivated 24 h and measure antibacterial circle diameter, and continue to cultivate 3-5 days, observe the antibacterial time.
Antibacterial time clocking method: pick up counting from antibacterial ring occurring, to antibacterial ring, grow again till first bacterium colony, be the antibacterial time.
Antibacterial time result of the test:
Unexpectedly, the inventive embodiments of handling with Rhizoma Zingiberis Recens extract 4 is opposite fully with the contrast fungistatic effect of the inventive embodiments 3 of using Bulbus Allii extract moistening, fermentation process.In other words, with contrivance antimicrobial spectrum and antibacterial time that Rhizoma Zingiberis Recens is handled, the contrivance of handling with Bulbus Allii extract compares, and evident difference is all arranged: its fungistatic effect of Rhizoma Zingiberis Recens fermented product is significantly better than big Bulbus Allii fermented product, and this may be relevant with competitive microbial ecological.Now will invent implement 4 with embodiment 3 to make laboratory report as follows:
Respectively get inventive embodiments 3,4 sample 50g, put into clean 1000ml flask respectively.Press 1:1 respectively, 1:6,1:10, the ratio of 1:15 adds sterilized water, and each reflux, extract, 0.5-2 hour, filter, Bulbus Allii, the ginger extract of getting the variable concentrations gradient after the filtration are standby, and above Concentraton gradient is made as A successively, and B, C, D handle number.Wherein A, C group was extracted 0.5 hour, and B, D group was extracted 2 hours.
Bacterium liquid preparation: get escherichia coli, bacillus cereus, dysentery bacterium, staphylococcus aureus strains tested test tube, draw 5 ml sterilized water, wash bacterium colony, and make its mix homogeneously, be mixed with and be no less than 50～100 cfu/ml bacterium liquid with suction pipe, standby.
The preparation of culture medium: Carnis Bovis seu Bubali cream peptone culture medium: beef 3g, peptone 10 g, NaCl 5 g, agar 15-20 g make 1000 ml, 2,121 ℃ of 20 min that sterilize down of pH 7. 0-7..
Bacteriostatic test: culture medium after sterilization 20 ml are poured into make flat board in the sterile petri dish.Draw 0.5ml bacterium liquid in plating medium with aseptic straw, pour one deck culture medium mixing more thereon into, bacteria suspension and culture medium are evenly distributed in the flat board.With aseptic card punch filter paper is broken into diameter 6 mm disks,, be immersed in Bulbus Allii, the ginger extract through sterilization, whenever folded 4, paste flat board, each common horizontalization plate 4 is folded.The culture dish that posts filter paper is inverted, in 30 ℃ of incubators, is cultivated 24 h and measure antibacterial circle diameter, and continue to cultivate 3-5 days, observe the antibacterial time.
Antibacterial time clocking method: pick up counting from antibacterial ring occurring, to antibacterial ring, grow again till first bacterium colony, be the antibacterial time.
Antibacterial time result of the test:
Unexpectedly, the inventive embodiments of handling with Rhizoma Zingiberis Recens extract 4 is opposite fully with the contrast fungistatic effect of the inventive embodiments 3 of using Bulbus Allii extract moistening, fermentation process.In other words, with contrivance antimicrobial spectrum and antibacterial time that Rhizoma Zingiberis Recens is handled, the contrivance of handling with Bulbus Allii extract compares, and evident difference is all arranged: its fungistatic effect of Rhizoma Zingiberis Recens fermented product is significantly better than big Bulbus Allii fermented product, and this may be relevant with competitive microbial ecological.Now will invent implement 4 with embodiment 3 to make laboratory report as follows:
Respectively get inventive embodiments 3,4 sample 50g, put into clean 1000ml flask respectively.Press 1:1 respectively, 1:6,1:10, the ratio of 1:15 adds sterilized water, and each reflux, extract, 0.5-2 hour, filter, Bulbus Allii, the ginger extract of getting the variable concentrations gradient after the filtration are standby, and above Concentraton gradient is made as A successively, and B, C, D handle number.Wherein A, C group was extracted 0.5 hour, and B, D group was extracted 2 hours.
Bacterium liquid preparation: get escherichia coli, bacillus cereus, dysentery bacterium, staphylococcus aureus strains tested test tube, draw 5 ml sterilized water, wash bacterium colony, and make its mix homogeneously, be mixed with and be no less than 50～100 cfu/ml bacterium liquid with suction pipe, standby.
The preparation of culture medium: Carnis Bovis seu Bubali cream peptone culture medium: beef 3g, peptone 10 g, NaCl 5 g, agar 15-20 g make 1000 ml, 2,121 ℃ of 20 min that sterilize down of pH 7. 0-7..
Bacteriostatic test: culture medium after sterilization 20 ml are poured into make flat board in the sterile petri dish.Draw 0.5ml bacterium liquid in plating medium with aseptic straw, pour one deck culture medium mixing more thereon into, bacteria suspension and culture medium are evenly distributed in the flat board.With aseptic card punch filter paper is broken into diameter 6 mm disks,, be immersed in Bulbus Allii, the ginger extract through sterilization, whenever folded 4, paste flat board, each common horizontalization plate 4 is folded.The culture dish that posts filter paper is inverted, in 30 ℃ of incubators, is cultivated 24 h and measure antibacterial circle diameter, and continue to cultivate 3-5 days, observe the antibacterial time.
Antibacterial time clocking method: pick up counting from antibacterial ring occurring, to antibacterial ring, grow again till first bacterium colony, be the antibacterial time.
Antibacterial time result of the test:
As seen last table selects bacterium Chinese medicine extract amount of water to be controlled within the 1:10 in the contrivance, and selects Chinese medicine extremely sensitive to the strain scope, and utmost point significant difference (P＜0.01) is arranged.
Because the effect of the anti-pestilent cold of Chinese medicine except bacteriostasis, should also be considered the complex effect of effects such as anti-stress, antiinflammatory, anti-immunity.But obtained beyond thought effect with regard to antibacterial effect method of the present invention, cured cold with the doctor trained in Western medicine antibiotic and compare, the present invention has the advantage and the characteristics of tangible many target position and systematic treating.
Embodiment 6
Get Radix Rehmanniae 20g, Rhizoma Anemarrhenae 30g, Bulbus Allii Macrostemonis 10g, Radix Glycyrrhizae 100g, Rhizoma Cyperi 10g, Rhizoma Atractylodis 35g, Rhizoma Acori Graminei 30g, Cortex Magnoliae Officinalis (system) 20g, Rhizoma Et Radix Notopterygii 50g, Pericarpium Citri Reticulatae (system) 10g, Rhizoma Osmundae 50g, Radix Bupleuri 10g, Rhizoma Pinelliae (processed) 10g, Rhizoma Chuanxiong (processed with wine) 10g, Herba Menthae 35g, Fructus Aurantii 10g, Flos Lonicerae 50g, Radix Platycodonis 10g, Herba Schizonepetae 10g, Herba Pogostemonis 10g, Folium Camelliae sinensis 30g, above medical material, pulverize separately becomes coarse powder, No. two sieves of whole mistakes (24 order), be less than 40% by No. four sieves (65 order), particle diameter 0.85～0.25mm, mixing, get Bulbus Allii 80g, section is added a cover, add the about 400g of water and decocted 2 hours, the waste extracting juice adds in the above-mentioned coarse powder, make and moisteningly evenly place fermentation 2 days, fry to little Jiao with slow fire, drying, briquet, every 6g, use the 1-2 piece at every turn, decocted every day 1-2 time 0.5 hour.
Embodiment 7
Get Radix Sophorae Tonkinensis 10g, Radix Arnebiae (Radix Lithospermi) 15g, Cortex Phellodendri 15g, Radix Glycyrrhizae 30g, Rhizoma Cyperi 50g, Rhizoma Atractylodis 80g, Rhizoma Acori Graminei 10g, Cortex Magnoliae Officinalis (system) 60g, Rhizoma Et Radix Notopterygii 10g, Pericarpium Citri Reticulatae (system) 50g, Rhizoma Osmundae 10g, Radix Bupleuri 50g, Rhizoma Pinelliae (processed) 10-50g, Rhizoma Chuanxiong (processed with wine) 50g, Herba Menthae 35g, Fructus Aurantii 10g, Radix Mussaendae 40g, Radix Platycodonis 10g, Herba Schizonepetae 10g, Herba Pogostemonis 10g, Folium Camelliae sinensis 20g, above medical material, pulverize separately becomes coarse powder, No. two sieves of whole mistakes 24 orders, be less than 40% by No. four sieve 65 orders, particle diameter 0.85～0.25mm, mixing, get Rhizoma Zingiberis Recens 50g, section adds the about 400g of water and decocted 2 hours, waste, extracting juice adds in the above-mentioned coarse powder, make and moisteningly evenly place fermentation 1 day, fry to little Jiao with slow fire, drying, every bag of 6g packing is also made teabag, each 1-2 bag.
Embodiment 8
Get Bulbus Lilii 10g, Folium Perillae 15g, Radix Sophorae Tonkinensis 30g, Radix Salviae Miltiorrhizae 10g, Rhizoma Atractylodis 35g, Rhizoma Acori Graminei 10g, Cortex Magnoliae Officinalis (system) 20g, Rhizoma Et Radix Notopterygii 10g, Pericarpium Citri Reticulatae (system) 10g, Rhizoma Osmundae 10g, Radix Bupleuri 10g, Rhizoma Pinelliae (processed) 50g, Rhizoma Chuanxiong (processed with wine) 10g, Herba Menthae 10g, Fructus Aurantii 65g, Radix Mussaendae 65g, Radix Platycodonis 50g, Herba Schizonepetae 50g, Herba Pogostemonis 50g, Folium Camelliae sinensis 80g, above medical material, pulverize separately becomes coarse powder, and No. two sieves of whole mistakes 24 orders are less than 40% by No. four sieve 65 orders, particle diameter 0.85～0.25mm, mixing is got Bulbus Allii 100g, section, add the about 600g of water and decocted waste, extracting juice 0.5 hour, add in the above-mentioned coarse powder, make moistening evenly, place fermentation 1 day, fry to little Jiao with slow fire, drying, promptly.
Claims (5)
1. medicinal tea Chinese medicine of concocting with microbe fermentation method is characterized in that: this medicinal tea Chinese medicine is to make powder, be pressed into piece or make teabag after will having the Chinese crude drug extracting solution fermentation of bacteriostasis.
2. a kind of medicinal tea Chinese medicine of concocting with microbe fermentation method according to claim 1 is characterized in that: described Chinese crude drug with bacteriostasis is in the Chinese crude drug that has bacteriostasis in external bacterium culture test one or more.
3. a kind of medicinal tea Chinese medicine of concocting with microbe fermentation method according to claim 1 and 2, it is characterized in that: described medicinal tea Chinese medicine optimization formula is:
Folium Perillae 10 ~ 50g, Herba Moslae 10 ~ 50g, Radix Glycyrrhizae 30 ~ 100g, Rhizoma Cyperi 10 ~ 50g, Rhizoma Atractylodis 35 ~ 80g, Rhizoma Acori Graminei 10 ~ 30g, Cortex Magnoliae Officinalis 20 ~ 60g, Rhizoma Et Radix Notopterygii 10 ~ 50g, Pericarpium Citri Reticulatae 10 ~ 50g, Rhizoma Osmundae 10 ~ 50g, Radix Bupleuri 10 ~ 50g, the Rhizoma Pinelliae 10 ~ 50g, Rhizoma Chuanxiong (processed with wine) 10 ~ 50g, Herba Menthae 10 ~ 35g, Fructus Aurantii 10 ~ 65g, Radix Mussaendae 40 ~ 65g, Radix Platycodonis 10 ~ 50g, Herba Schizonepetae 10 ~ 50g, Herba Pogostemonis 10 ~ 50g, Herba Ephedrae 0 ~ 20g, Bulbus Allii or Rhizoma Zingiberis Recens 40 ~ 100g.
4. a kind of medicinal tea Chinese medicine of concocting with microbe fermentation method according to claim 3, it is characterized in that: described medicinal tea Chinese medicine also contains Folium Camelliae sinensis, and the content of described Folium Camelliae sinensis is 20 ~ 80g.
5. a kind of medicinal tea Chinese medicine of concocting with microbe fermentation method according to claim 4, it is characterized in that: described medicinal tea preparation method of Chinese medicine is as follows: with Folium Perillae 10 ~ 50g, Herba Moslae 10 ~ 50g, Radix Glycyrrhizae 30 ~ 100g, Rhizoma Cyperi 10 ~ 50g, Rhizoma Atractylodis 35 ~ 80g, Rhizoma Acori Graminei 10 ~ 30g, Cortex Magnoliae Officinalis 20 ~ 60g, Rhizoma Et Radix Notopterygii 10 ~ 50g, Pericarpium Citri Reticulatae 10 ~ 50g, Rhizoma Osmundae 10 ~ 50g, Radix Bupleuri 10 ~ 50g, the Rhizoma Pinelliae 10 ~ 50g, Rhizoma Chuanxiong (processed with wine) 10 ~ 50g, Herba Menthae 10 ~ 35g, Fructus Aurantii 10 ~ 65g, Radix Mussaendae 40 ~ 65g, Radix Platycodonis 10 ~ 50g, Herba Schizonepetae 10 ~ 50g, Herba Pogostemonis 10 ~ 50g, Herba Ephedrae 0 ~ 20g, Folium Camelliae sinensis 20 ~ 80g, pulverize separately becomes coarse powder, and mixing is standby, get Bulbus Allii or Rhizoma Zingiberis Recens 40-100g, section, 6-10 times of water gaging of adding section weight, decocted 0.5-2 hour, the extracting juice waste adds the juice of obtaining in the above-mentioned medicinal material coarse powder, evenly moistening, place room temperature fermentation 1-3 days, fry to little Jiao with slow fire, dry then, be distributed into bag, or make teabag or briquet.
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| CN103555592A (en) * | 2013-11-07 | 2014-02-05 | 沂源康源生物科技有限公司 | Preparation method of Aspergillus oryzae strain and spore powder |
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| WO2012089175A3 (en) * | 2010-12-31 | 2012-09-20 | 永富亚洲集团有限公司 | Traditional chinese medicinal tea made by microbial fermentation method |
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| CN103555592B (en) * | 2013-11-07 | 2015-05-20 | 沂源康源生物科技有限公司 | Preparation method of Aspergillus oryzae strain and spore powder |
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